Result of FASTA (omim) for
pF1KE2374
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2374, 284 aa
1>>>pF1KE2374 284 - 284 aa - 284 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1373+/-0.000327; mu= 15.9323+/- 0.020
mean_var=62.6997+/-12.901, 0's: 0 Z-trim(114.6): 9 B-trim: 1406 in 1/55
Lambda= 0.161973
statistics sampled from 24501 (24510) to 24501 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.287), width: 16
Scan time: 7.080
The best scores are: opt bits E(85289)
NP_003625 (OMIM: 603249) protein NipSnap homolog 1 ( 284) 1970 468.8 5.3e-132
NP_001189431 (OMIM: 603249) protein NipSnap homolo ( 264) 1770 422.0 5.8e-118
NP_001474 (OMIM: 603004) protein NipSnap homolog 2 ( 286) 1383 331.6 1e-90
NP_001189398 (OMIM: 603004) protein NipSnap homolo ( 247) 791 193.2 4.1e-49
NP_060846 (OMIM: 608872) protein NipSnap homolog 3 ( 247) 257 68.4 1.5e-11
NP_056284 (OMIM: 608871) protein NipSnap homolog 3 ( 247) 233 62.8 7.2e-10
XP_016870378 (OMIM: 608872) PREDICTED: protein Nip ( 231) 232 62.6 8.1e-10
NP_001316499 (OMIM: 608871) protein NipSnap homolo ( 197) 184 51.3 1.7e-06
XP_011517141 (OMIM: 608872) PREDICTED: protein Nip ( 197) 160 45.7 8.2e-05
>>NP_003625 (OMIM: 603249) protein NipSnap homolog 1 iso (284 aa)
initn: 1970 init1: 1970 opt: 1970 Z-score: 2490.9 bits: 468.8 E(85289): 5.3e-132
Smith-Waterman score: 1970; 100.0% identity (100.0% similar) in 284 aa overlap (1-284:1-284)
10 20 30 40 50 60
pF1KE2 MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 QAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 GPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDL
190 200 210 220 230 240
250 260 270 280
pF1KE2 QSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
::::::::::::::::::::::::::::::::::::::::::::
NP_003 QSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
250 260 270 280
>>NP_001189431 (OMIM: 603249) protein NipSnap homolog 1 (264 aa)
initn: 1768 init1: 1768 opt: 1770 Z-score: 2238.7 bits: 422.0 E(85289): 5.8e-118
Smith-Waterman score: 1789; 93.0% identity (93.0% similar) in 284 aa overlap (1-284:1-264)
10 20 30 40 50 60
pF1KE2 MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHS
::::::::::::: :::::::::::::::::::::::::::
NP_001 MAPRLCSISVTAR--------------------FYSKDNEGSWFRSLFVHKVDPRKDAHS
10 20 30 40
70 80 90 100 110 120
pF1KE2 TLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQD
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 QAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRM
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 GPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDL
170 180 190 200 210 220
250 260 270 280
pF1KE2 QSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
230 240 250 260
>>NP_001474 (OMIM: 603004) protein NipSnap homolog 2 iso (286 aa)
initn: 1383 init1: 1383 opt: 1383 Z-score: 1749.5 bits: 331.6 E(85289): 1e-90
Smith-Waterman score: 1383; 75.5% identity (93.2% similar) in 249 aa overlap (36-284:38-286)
10 20 30 40 50 60
pF1KE2 CSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSK
... : ::..::::.::::::::::.::.:
NP_001 ARGAAWAGGLLQRAAPCSLLPRLRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHL
::::::::.:::::::: :.:::.. . ::::.: :. :::.:::.::::::::::::::
NP_001 KETSNLYKLQFHNVKPECLEAYNKICQEVLPKIHEDKHYPCTLVGTWNTWYGEQDQAVHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 WRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIY
::. :::::: . ::::..:::.::::. ::.:::::.::::::::::::: :: :::::
NP_001 WRYEGGYPALTEVMNKLRENKEFLEFRKARSDMLLSRKNQLLLEFSFWNEPVPRSGPNIY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 ELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREE
:::.:.:.::::::::: :::::..::...:::::::::::.::.:::::::.:::.::.
NP_001 ELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTRED
190 200 210 220 230 240
250 260 270 280
pF1KE2 TRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
:::::.:.::.: :::::::...:::::::::: ::::
NP_001 IRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ
250 260 270 280
>>NP_001189398 (OMIM: 603004) protein NipSnap homolog 2 (247 aa)
initn: 984 init1: 791 opt: 791 Z-score: 1002.8 bits: 193.2 E(85289): 4.1e-49
Smith-Waterman score: 923; 58.6% identity (75.1% similar) in 249 aa overlap (36-284:38-247)
10 20 30 40 50 60
pF1KE2 CSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSK
... : ::..::::.::::::::::.::.:
NP_001 ARGAAWAGGLLQRAAPCSLLPRLRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHL
::::::::.::. .. ..: :: :.: ..
NP_001 KETSNLYKLQFKRCCQRFTKINTTL---VL-------------------WWGLGTRG---
70 80 90 100
130 140 150 160 170 180
pF1KE2 WRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIY
: .:: :.::::. ::.:::::.::::::::::::: :: :::::
NP_001 ----------MASRTKL----EFLEFRKARSDMLLSRKNQLLLEFSFWNEPVPRSGPNIY
110 120 130 140
190 200 210 220 230 240
pF1KE2 ELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREE
:::.:.:.::::::::: :::::..::...:::::::::::.::.:::::::.:::.::.
NP_001 ELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGFFSQIGQLYMVHHLWAYRDLQTRED
150 160 170 180 190 200
250 260 270 280
pF1KE2 TRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
:::::.:.::.: :::::::...:::::::::: ::::
NP_001 IRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ
210 220 230 240
>>NP_060846 (OMIM: 608872) protein NipSnap homolog 3B [H (247 aa)
initn: 196 init1: 99 opt: 257 Z-score: 328.4 bits: 68.4 E(85289): 1.5e-11
Smith-Waterman score: 257; 25.8% identity (58.1% similar) in 229 aa overlap (65-284:30-247)
40 50 60 70 80 90
pF1KE2 YSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAV
.. ...:... . .:: ..:. : .
NP_060 MLVLRSGLTKALASRTLAPQVCSSFATGPRQYDGTFYEFRTYYLKPSNMNAF---MENL
10 20 30 40 50
100 110 120 130 140 150
pF1KE2 LPKLHLDEDYPCSLVGNWNTWYG-EQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRR
..:: .: ::: :.. .: . ... :.:.... . . . : : ::. .
NP_060 KKNIHLRTSYS-ELVGFWSVEFGGRTNKVFHIWKYDN-FAHRAEVRKALANCKEW----Q
60 70 80 90 100 110
160 170 180 190 200
pF1KE2 ERSQML-LSRRNQLLLEFSF---WN--EPQPRMGPNIYELRTYKLKPGTMIEWGNNWARA
:.: . :.: .. :... :. : :. : .::: ....::: ::. . ::
NP_060 EQSIIPNLARIDKQETEITYLIPWSKLEKPPKEG--VYELAVFQMKPGGPALWGDAFERA
120 130 140 150 160
210 220 230 240 250 260
pF1KE2 IKYRQE--NQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVP
:. . . ..:: : .. ::: :: :: .. .:: :. . . : .:
NP_060 INAHVNLGYTKVVGVFHTEYGELNRVHVLWWNESADSRAAGRHKSHEDPRVVAAVRESVN
170 180 190 200 210 220
270 280
pF1KE2 LVRHMESRIMIPLKISPLQ
. ... ..:: ..:::.
NP_060 YLVSQQNMLLIPASFSPLK
230 240
>>NP_056284 (OMIM: 608871) protein NipSnap homolog 3A is (247 aa)
initn: 192 init1: 93 opt: 233 Z-score: 298.1 bits: 62.8 E(85289): 7.2e-10
Smith-Waterman score: 233; 22.9% identity (53.9% similar) in 245 aa overlap (45-284:10-247)
20 30 40 50 60 70
pF1KE2 LLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKI
:.: . . :. . . .. . .:..
NP_056 MLVLRSALTRALASRTLAPQMCSSFATGPRQYDGIFYEF
10 20 30
80 90 100 110 120 130
pF1KE2 QFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYG-EQDQAVHLWRFSGGYP
. . .:: . : . : . :: . ::: :.. .: ... . :.:.... .
NP_056 RSYYLKPSKM---NEFLENFEKNAHLRTAHS-ELVGYWSVEFGGRMNTVFHIWKYDN-FA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE2 ALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWN--EPQPRMGPNIYELRTYK
. . : ..::. : . :...... . . : : :. : .::: :..
NP_056 HRTEVRKALAKDKEWQEQFLIPNLALIDKQESEITYLVPWCKLEKPPKEG--VYELATFQ
100 110 120 130 140 150
200 210 220 230 240
pF1KE2 LKPGTMIEWGNNWARAIKYRQE--NQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNA
.::: ::. . ::.. . . . :: : .. : : :: :: .. .:: :.
NP_056 MKPGGPALWGDAFKRAVHAHVNLGYTKLVGVFHTEYGALNRVHVLWWNESADSRAAGRHK
160 170 180 190 200 210
250 260 270 280
pF1KE2 AWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
. . : .: . ... ..:: ..:::.
NP_056 SHEDPRVVAAVRESVNYLVSQQNMLLIPTSFSPLK
220 230 240
>>XP_016870378 (OMIM: 608872) PREDICTED: protein NipSnap (231 aa)
initn: 170 init1: 86 opt: 232 Z-score: 297.3 bits: 62.6 E(85289): 8.1e-10
Smith-Waterman score: 232; 26.9% identity (59.1% similar) in 193 aa overlap (65-248:30-211)
40 50 60 70 80 90
pF1KE2 YSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAV
.. ...:... . .:: ..:. : .
XP_016 MLVLRSGLTKALASRTLAPQVCSSFATGPRQYDGTFYEFRTYYLKPSNMNAF---MENL
10 20 30 40 50
100 110 120 130 140 150
pF1KE2 LPKLHLDEDYPCSLVGNWNTWYG-EQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRR
..:: .: ::: :.. .: . ... :.:.... . . . : : ::. .
XP_016 KKNIHLRTSYS-ELVGFWSVEFGGRTNKVFHIWKYDN-FAHRAEVRKALANCKEW----Q
60 70 80 90 100 110
160 170 180 190 200
pF1KE2 ERSQML-LSRRNQLLLEFSF---WN--EPQPRMGPNIYELRTYKLKPGTMIEWGNNWARA
:.: . :.: .. :... :. : :. : .::: ....::: ::. . ::
XP_016 EQSIIPNLARIDKQETEITYLIPWSKLEKPPKEG--VYELAVFQMKPGGPALWGDAFERA
120 130 140 150 160
210 220 230 240 250 260
pF1KE2 IKYRQE--NQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVP
:. . . ..:: : .. ::: :: :: .. .:: :.
XP_016 INAHVNLGYTKVVGVFHTEYGELNRVHVLWWNESADSRAAGRHKSHEDPRVVAAGRETDM
170 180 190 200 210 220
270 280
pF1KE2 LVRHMESRIMIPLKISPLQ
XP_016 QPI
230
>>NP_001316499 (OMIM: 608871) protein NipSnap homolog 3A (197 aa)
initn: 166 init1: 87 opt: 184 Z-score: 237.7 bits: 51.3 E(85289): 1.7e-06
Smith-Waterman score: 184; 29.6% identity (59.3% similar) in 135 aa overlap (149-277:2-133)
120 130 140 150 160 170
pF1KE2 QDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQP
: .: .. : :: . :: . :.
NP_001 MLVLRSALTRALASRTLAPQMCSSFATGPRQ
10 20 30
180 190 200 210 220 230
pF1KE2 RMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIG-ELYVVHHLWAY
: .::.:.: :::. : :. .:. . . : ..: :: . ..: .. .: :.: :
NP_001 YDGI-FYEFRSYYLKPSKMNEFLENFEKNAHLRTAHSELVGYWSVEFGGRMNTVFHIWKY
40 50 60 70 80 90
240 250 260 270 280
pF1KE2 KDLQSREETRNAAWRKRGWDENVYYTVP---LVRHMESRI--MIPLKISPLQ
.. : :.:.: . . :.:. . .: :. ..::.: ..:
NP_001 DNFAHRTEVRKALAKDKEWQEQ--FLIPNLALIDKQESEITYLVPWCKLEKPPKEVHVLW
100 110 120 130 140
NP_001 WNESADSRAAGRHKSHEDPRVVAAVRESVNYLVSQQNMLLIPTSFSPLK
150 160 170 180 190
>>XP_011517141 (OMIM: 608872) PREDICTED: protein NipSnap (197 aa)
initn: 161 init1: 85 opt: 160 Z-score: 207.4 bits: 45.7 E(85289): 8.2e-05
Smith-Waterman score: 160; 29.3% identity (57.1% similar) in 133 aa overlap (149-277:2-133)
120 130 140 150 160 170
pF1KE2 QDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQP
: .: .. : :: . :: . :.
XP_011 MLVLRSGLTKALASRTLAPQVCSSFATGPRQ
10 20 30
180 190 200 210 220 230
pF1KE2 RMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIG-ELYVVHHLWAY
: ..::.::: :::..: . .: . :. : .: :: . ..: . : :.: :
XP_011 YDG-TFYEFRTYYLKPSNMNAFMENLKKNIHLRTSYSELVGFWSVEFGGRTNKVFHIWKY
40 50 60 70 80 90
240 250 260 270 280
pF1KE2 KDLQSREETRNAAWRKRGWDE-NVYYTVPLVRHMESRI--MIPLKISPLQ
.. : :.:.: . :.: .. .. . ..:..: .::
XP_011 DNFAHRAEVRKALANCKEWQEQSIIPNLARIDKQETEITYLIPWSKLEKPPKEVHVLWWN
100 110 120 130 140 150
XP_011 ESADSRAAGRHKSHEDPRVVAAVRESVNYLVSQQNMLLIPASFSPLK
160 170 180 190
284 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:56:18 2016 done: Sun Nov 6 12:56:19 2016
Total Scan time: 7.080 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]