Result of FASTA (omim) for
pF1KE2326
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2326, 526 aa
1>>>pF1KE2326 526 - 526 aa - 526 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.1850+/-0.000754; mu= -13.8630+/- 0.045
mean_var=891.2962+/-201.331, 0's: 0 Z-trim(116.0): 1213 B-trim: 1520 in 1/53
Lambda= 0.042960
statistics sampled from 25274 (26769) to 25274 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.661), E-opt: 0.2 (0.314), width: 16
Scan time: 10.170
The best scores are: opt bits E(85289)
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 3567 237.8 6.2e-62
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 3550 236.7 1.3e-61
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 3403 227.6 7e-59
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 3403 227.6 7e-59
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 3403 227.6 7e-59
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 3386 226.5 1.4e-58
NP_002341 (OMIM: 165120) tyrosine-protein kinase L ( 512) 2454 168.8 3.6e-41
XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-pr ( 682) 2419 166.8 1.9e-40
NP_001104567 (OMIM: 165120) tyrosine-protein kinas ( 491) 2409 166.0 2.4e-40
XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-pr ( 491) 2409 166.0 2.4e-40
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 2276 157.7 7.4e-38
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 2276 157.7 7.4e-38
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 2185 152.1 3.7e-36
NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 2132 148.7 3.3e-35
XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543) 2055 144.1 1e-33
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 2055 144.1 1e-33
XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 2044 143.4 1.6e-33
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 2044 143.4 1.6e-33
XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 2044 143.4 1.6e-33
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 2044 143.4 1.6e-33
XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 2044 143.4 1.6e-33
XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 2044 143.4 1.6e-33
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 2019 141.9 4.8e-33
XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 2019 141.9 4.8e-33
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1950 137.6 9.2e-32
XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536) 1950 137.6 9.2e-32
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1950 137.6 9.2e-32
XP_006710515 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1938 136.8 1.5e-31
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 1938 136.8 1.5e-31
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 1938 136.8 1.5e-31
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 1938 136.8 1.5e-31
XP_011539312 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1938 136.8 1.5e-31
XP_016883516 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1937 136.8 1.6e-31
XP_016883515 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1937 136.8 1.6e-31
XP_016883514 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1937 136.8 1.6e-31
XP_016883513 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1937 136.8 1.6e-31
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1590 115.2 4.7e-25
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1590 115.2 4.7e-25
XP_011539313 (OMIM: 164940) PREDICTED: tyrosine-pr ( 460) 1523 111.0 7.9e-24
XP_005258196 (OMIM: 164880) PREDICTED: tyrosine-pr ( 499) 1510 110.3 1.4e-23
XP_011539316 (OMIM: 164940) PREDICTED: tyrosine-pr ( 325) 1394 102.8 1.7e-21
XP_016856162 (OMIM: 164940) PREDICTED: tyrosine-pr ( 325) 1394 102.8 1.7e-21
XP_016856163 (OMIM: 164940) PREDICTED: tyrosine-pr ( 325) 1394 102.8 1.7e-21
XP_016868904 (OMIM: 165120) PREDICTED: tyrosine-pr ( 499) 1342 99.8 2e-20
>>NP_002101 (OMIM: 142370) tyrosine-protein kinase HCK i (526 aa)
initn: 3567 init1: 3567 opt: 3567 Z-score: 1232.9 bits: 237.8 E(85289): 6.2e-62
Smith-Waterman score: 3567; 100.0% identity (100.0% similar) in 526 aa overlap (1-526:1-526)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
430 440 450 460 470 480
490 500 510 520
pF1KE2 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
490 500 510 520
>>NP_001165601 (OMIM: 142370) tyrosine-protein kinase HC (525 aa)
initn: 3018 init1: 3018 opt: 3550 Z-score: 1227.2 bits: 236.7 E(85289): 1.3e-61
Smith-Waterman score: 3550; 99.8% identity (99.8% similar) in 526 aa overlap (1-526:1-525)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPNSHNSNTPGIRE-GSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
420 430 440 450 460 470
490 500 510 520
pF1KE2 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500 510 520
>>NP_001165604 (OMIM: 142370) tyrosine-protein kinase HC (505 aa)
initn: 3403 init1: 3403 opt: 3403 Z-score: 1178.1 bits: 227.6 E(85289): 7e-59
Smith-Waterman score: 3403; 100.0% identity (100.0% similar) in 505 aa overlap (22-526:1-505)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
:::::::::::::::::::::::::::::::::::::::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
400 410 420 430 440 450
490 500 510 520
pF1KE2 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
460 470 480 490 500
>>NP_001165600 (OMIM: 142370) tyrosine-protein kinase HC (505 aa)
initn: 3403 init1: 3403 opt: 3403 Z-score: 1178.1 bits: 227.6 E(85289): 7e-59
Smith-Waterman score: 3403; 100.0% identity (100.0% similar) in 505 aa overlap (22-526:1-505)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
:::::::::::::::::::::::::::::::::::::::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
400 410 420 430 440 450
490 500 510 520
pF1KE2 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
460 470 480 490 500
>>NP_001165603 (OMIM: 142370) tyrosine-protein kinase HC (506 aa)
initn: 3403 init1: 3403 opt: 3403 Z-score: 1178.1 bits: 227.6 E(85289): 7e-59
Smith-Waterman score: 3403; 100.0% identity (100.0% similar) in 505 aa overlap (22-526:2-506)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
:::::::::::::::::::::::::::::::::::::::
NP_001 MMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30 40
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
410 420 430 440 450 460
490 500 510 520
pF1KE2 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
470 480 490 500
>>NP_001165602 (OMIM: 142370) tyrosine-protein kinase HC (504 aa)
initn: 3018 init1: 3018 opt: 3386 Z-score: 1172.4 bits: 226.5 E(85289): 1.4e-58
Smith-Waterman score: 3386; 99.8% identity (99.8% similar) in 505 aa overlap (22-526:1-504)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
:::::::::::::::::::::::::::::::::::::::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPNSHNSNTPGIRE-GSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
400 410 420 430 440 450
490 500 510 520
pF1KE2 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
460 470 480 490 500
>>NP_002341 (OMIM: 165120) tyrosine-protein kinase Lyn i (512 aa)
initn: 1370 init1: 1262 opt: 2454 Z-score: 860.2 bits: 168.8 E(85289): 3.6e-41
Smith-Waterman score: 2456; 70.5% identity (86.0% similar) in 516 aa overlap (22-526:1-512)
10 20 30 40 50
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFS------KTETSASPHCPVYVPD
:::.::: : ...: ::. . . .:: :
NP_002 MGCIKSK----GKDSLSDDGVDLKTQPVRNTERTIYVRD
10 20 30
60 70 80 90 100 110
pF1KE2 PTSTIKPGPNSHNSNTPGIR----EAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEE
:::. . : ... :: : . . :::::: :..:: .::::.::..: ::::
NP_002 PTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE2 SGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMI
::::::.:: :.:::.:::::::....::::::::: :.::::::::::::: :.:.:
NP_002 HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE2 RDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGN
:.::: :::.::::::.:: .::..::::::.:::::.::::: :: ..... ::.:
NP_002 RESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQA
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 DGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVK
::::..: :.: ::::::.::::::::::.:: :.:::::::::::. ::. ::::::
NP_002 DGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVK
220 230 240 250 260 270
300 310 320 330 340
pF1KE2 TMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDE
:.:::.:::.::: :::.::::::::::.:.::::.: :::::::.::::::::::::::
NP_002 TLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDE
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE2 GSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDN
:.: ::::::::::::::::.::..:::::::::::.::: ::.:::::::::::::::
NP_002 GGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDN
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE2 EYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRA
::::::::::::::::::::::: ::::::::::::::.::::::.::::: .: .:. :
NP_002 EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTA
400 410 420 430 440 450
470 480 490 500 510 520
pF1KE2 LERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
: .:::::: ::::.:::.:: :::.. ::::::.:.::::::::::::.::::::
NP_002 LSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
460 470 480 490 500 510
>>XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-protei (682 aa)
initn: 1287 init1: 1262 opt: 2419 Z-score: 847.3 bits: 166.8 E(85289): 1.9e-40
Smith-Waterman score: 2419; 68.4% identity (84.9% similar) in 531 aa overlap (2-526:158-682)
10 20 30
pF1KE2 MGGRSS-CEDPGCPRDEERAPRMGCMKSKFL
:::.. :. :: .: . ... :
XP_011 SRRAGPRCRSLPGRGASGPDALQPPARGKRGGRATPGPAPAAPRRASSVPGQQPPHTQVL
130 140 150 160 170 180
40 50 60 70 80
pF1KE2 ---QVGGNTFSKTETSASPHCPVYVPD-PTSTIKPGPNSHNSNTPGIREAGSEDIIVVAL
:. :..... .: : . : : . :: . ... : .: :. :::::
XP_011 LGRPVAPPTLNSSHRGAPPPRNFHRERVPESQLLPG-QRFQTKDP--EEQGD---IVVAL
190 200 210 220 230 240
90 100 110 120 130 140
pF1KE2 YDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFF
: :..:: .::::.::..: :::: ::::::.:: :.:::.:::::::....::::::::
XP_011 YPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFF
250 260 270 280 290 300
150 160 170 180 190 200
pF1KE2 KGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNG
: :.::::::::::::: :.:.::.::: :::.::::::.:: .::..::::::.::::
XP_011 KDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNG
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE2 GFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEK
:.::::: :: ..... ::.: ::::..: :.: ::::::.::::::::::.:: :
XP_011 GYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVK
370 380 390 400 410 420
270 280 290 300 310 320
pF1KE2 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK
.:::::::::::. ::. :::::::.:::.:::.::: :::.::::::::::.:.::::.
XP_011 RLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTR
430 440 450 460 470 480
330 340 350 360 370 380
pF1KE2 E-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAA
: :::::::.:::::::::::::::.: ::::::::::::::::.::..::::::::::
XP_011 EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAA
490 500 510 520 530 540
390 400 410 420 430 440
pF1KE2 NILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGI
:.::: ::.:::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_011 NVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGI
550 560 570 580 590 600
450 460 470 480 490 500
pF1KE2 LLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFE
::.::::::.::::: .: .:. :: .:::::: ::::.:::.:: :::.. ::::::.
XP_011 LLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFD
610 620 630 640 650 660
510 520
pF1KE2 YIQSVLDDFYTATESQYQQQP
:.::::::::::::.::::::
XP_011 YLQSVLDDFYTATEGQYQQQP
670 680
>>NP_001104567 (OMIM: 165120) tyrosine-protein kinase Ly (491 aa)
initn: 1321 init1: 1262 opt: 2409 Z-score: 845.3 bits: 166.0 E(85289): 2.4e-40
Smith-Waterman score: 2427; 71.1% identity (87.0% similar) in 506 aa overlap (22-526:1-491)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
:::.::: : ...: .. . . : : : .
NP_001 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLL
10 20 30
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
:: . ... : .: :. :::::: :..:: .::::.::..: :::: ::::::.::
NP_001 PG-QRFQTKDP--EEQGD---IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSL
40 50 60 70 80
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
:.:::.:::::::....::::::::: :.::::::::::::: :.:.::.::: :::.
NP_001 LTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSF
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::.:: .::..::::::.:::::.::::: :: ..... ::.: ::::..:
NP_001 SLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKA
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
:.: ::::::.::::::::::.:: :.:::::::::::. ::. :::::::.:::.:::.
NP_001 CISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQ
210 220 230 240 250 260
310 320 330 340 350
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI
::: :::.::::::::::.:.::::.: :::::::.:::::::::::::::.: :::::
NP_001 AFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE2 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKF
:::::::::::.::..:::::::::::.::: ::.:::::::::::::::::::::::::
NP_001 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE2 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP
::::::::::::: ::::::::::::::.::::::.::::: .: .:. :: .::::::
NP_001 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV
390 400 410 420 430 440
480 490 500 510 520
pF1KE2 ENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::.:::.:: :::.. ::::::.:.::::::::::::.::::::
NP_001 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
450 460 470 480 490
>>XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-protei (491 aa)
initn: 1321 init1: 1262 opt: 2409 Z-score: 845.3 bits: 166.0 E(85289): 2.4e-40
Smith-Waterman score: 2427; 71.1% identity (87.0% similar) in 506 aa overlap (22-526:1-491)
10 20 30 40 50 60
pF1KE2 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
:::.::: : ...: .. . . : : : .
XP_016 MGCIKSK----GKDSLSDDGVDLKTQ-----PVPESQLL
10 20 30
70 80 90 100 110 120
pF1KE2 PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
:: . ... : .: :. :::::: :..:: .::::.::..: :::: ::::::.::
XP_016 PG-QRFQTKDP--EEQGD---IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSL
40 50 60 70 80
130 140 150 160 170 180
pF1KE2 ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
:.:::.:::::::....::::::::: :.::::::::::::: :.:.::.::: :::.
XP_016 LTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSF
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE2 SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
::::::.:: .::..::::::.:::::.::::: :: ..... ::.: ::::..:
XP_016 SLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKA
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE2 CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
:.: ::::::.::::::::::.:: :.:::::::::::. ::. :::::::.:::.:::.
XP_016 CISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQ
210 220 230 240 250 260
310 320 330 340 350
pF1KE2 AFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI
::: :::.::::::::::.:.::::.: :::::::.:::::::::::::::.: :::::
XP_016 AFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE2 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKF
:::::::::::.::..:::::::::::.::: ::.:::::::::::::::::::::::::
XP_016 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE2 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP
::::::::::::: ::::::::::::::.::::::.::::: .: .:. :: .::::::
XP_016 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV
390 400 410 420 430 440
480 490 500 510 520
pF1KE2 ENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
::::.:::.:: :::.. ::::::.:.::::::::::::.::::::
XP_016 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
450 460 470 480 490
526 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:02:34 2016 done: Sun Nov 6 12:02:35 2016
Total Scan time: 10.170 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]