Result of FASTA (omim) for
pF1KE2019
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2019, 596 aa
1>>>pF1KE2019 596 - 596 aa - 596 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2055+/-0.00037; mu= 20.4205+/- 0.023
mean_var=83.2171+/-16.596, 0's: 0 Z-trim(113.4): 53 B-trim: 45 in 1/54
Lambda= 0.140594
statistics sampled from 23523 (23572) to 23523 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.623), E-opt: 0.2 (0.257), width: 16
Scan time: 5.180
The best scores are: opt bits E(91774)
XP_016869077 (OMIM: 605993,608782) pyruvate dehyro ( 591) 3825 786.2 0
NP_001155251 (OMIM: 605993,608782) pyruvate dehyro ( 562) 3818 784.7 0
NP_001155252 (OMIM: 605993,608782) pyruvate dehyro ( 562) 3818 784.7 0
XP_011515437 (OMIM: 605993,608782) pyruvate dehyro ( 555) 3725 765.9 0
NP_060914 (OMIM: 605993,608782) pyruvate dehyrogen ( 537) 3637 748.0 2e-215
NP_001155253 (OMIM: 605993,608782) pyruvate dehyro ( 537) 3637 748.0 2e-215
XP_011515438 (OMIM: 605993,608782) pyruvate dehyro ( 537) 3637 748.0 2e-215
NP_001316862 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316863 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_065837 (OMIM: 615499) [Pyruvate dehydrogenase [ ( 529) 1715 358.2 4.4e-98
NP_001316860 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316859 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316858 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316861 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_001316857 (OMIM: 615499) [Pyruvate dehydrogenas ( 529) 1715 358.2 4.4e-98
NP_003611 (OMIM: 114480,605100,617450) protein pho ( 605) 213 53.6 2.5e-06
>>XP_016869077 (OMIM: 605993,608782) pyruvate dehyrogena (591 aa)
initn: 3825 init1: 3825 opt: 3825 Z-score: 4194.8 bits: 786.2 E(91774): 0
Smith-Waterman score: 3825; 100.0% identity (100.0% similar) in 563 aa overlap (34-596:29-591)
10 20 30 40 50 60
pF1KE2 SALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAP
::::::::::::::::::::::::::::::
XP_016 MEGLALGAHPCSRLGPAALGCGFASPAGRMCVCPGPRRIGIPVRSSSLPLFSDAMPAP
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 TQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 YTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 DRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGR
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 ALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLD
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 NDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 WSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDL
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 QKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETM
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 HRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIR
480 490 500 510 520 530
550 560 570 580 590
pF1KE2 HAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
540 550 560 570 580 590
>>NP_001155251 (OMIM: 605993,608782) pyruvate dehyrogena (562 aa)
initn: 3818 init1: 3818 opt: 3818 Z-score: 4187.4 bits: 784.7 E(91774): 0
Smith-Waterman score: 3818; 100.0% identity (100.0% similar) in 562 aa overlap (35-596:1-562)
10 20 30 40 50 60
pF1KE2 ALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
::::::::::::::::::::::::::::::
NP_001 MCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
10 20 30
70 80 90 100 110 120
pF1KE2 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
460 470 480 490 500 510
550 560 570 580 590
pF1KE2 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
520 530 540 550 560
>>NP_001155252 (OMIM: 605993,608782) pyruvate dehyrogena (562 aa)
initn: 3818 init1: 3818 opt: 3818 Z-score: 4187.4 bits: 784.7 E(91774): 0
Smith-Waterman score: 3818; 100.0% identity (100.0% similar) in 562 aa overlap (35-596:1-562)
10 20 30 40 50 60
pF1KE2 ALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
::::::::::::::::::::::::::::::
NP_001 MCVCPGPRRIGIPVRSSSLPLFSDAMPAPT
10 20 30
70 80 90 100 110 120
pF1KE2 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQY
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIED
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRA
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDN
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSW
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQ
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMH
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRH
460 470 480 490 500 510
550 560 570 580 590
pF1KE2 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
520 530 540 550 560
>>XP_011515437 (OMIM: 605993,608782) pyruvate dehyrogena (555 aa)
initn: 3725 init1: 3725 opt: 3725 Z-score: 4085.5 bits: 765.9 E(91774): 0
Smith-Waterman score: 3725; 100.0% identity (100.0% similar) in 551 aa overlap (46-596:5-555)
20 30 40 50 60 70
pF1KE2 CCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCE
::::::::::::::::::::::::::::::
XP_011 MFERIPVRSSSLPLFSDAMPAPTQLFFPLIRNCE
10 20 30
80 90 100 110 120 130
pF1KE2 LSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE2 KFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTR
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE2 GMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHP
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 NDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE2 NSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNA
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE2 QNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQL
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE2 NDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEY
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE2 LTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVD
460 470 480 490 500 510
560 570 580 590
pF1KE2 HERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
:::::::::::::::::::::::::::::::::::::::::
XP_011 HERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
520 530 540 550
>>NP_060914 (OMIM: 605993,608782) pyruvate dehyrogenase (537 aa)
initn: 3637 init1: 3637 opt: 3637 Z-score: 3989.3 bits: 748.0 E(91774): 2e-215
Smith-Waterman score: 3637; 100.0% identity (100.0% similar) in 537 aa overlap (60-596:1-537)
30 40 50 60 70 80
pF1KE2 CDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHK
::::::::::::::::::::::::::::::
NP_060 MPAPTQLFFPLIRNCELSRIYGTACYCHHK
10 20 30
90 100 110 120 130 140
pF1KE2 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE2 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE2 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE2 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE2 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE2 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
460 470 480 490 500 510
570 580 590
pF1KE2 ARMYRDDITIIVVQFNSHVVGAYQNQE
:::::::::::::::::::::::::::
NP_060 ARMYRDDITIIVVQFNSHVVGAYQNQE
520 530
>>NP_001155253 (OMIM: 605993,608782) pyruvate dehyrogena (537 aa)
initn: 3637 init1: 3637 opt: 3637 Z-score: 3989.3 bits: 748.0 E(91774): 2e-215
Smith-Waterman score: 3637; 100.0% identity (100.0% similar) in 537 aa overlap (60-596:1-537)
30 40 50 60 70 80
pF1KE2 CDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHK
::::::::::::::::::::::::::::::
NP_001 MPAPTQLFFPLIRNCELSRIYGTACYCHHK
10 20 30
90 100 110 120 130 140
pF1KE2 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE2 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE2 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE2 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE2 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE2 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
460 470 480 490 500 510
570 580 590
pF1KE2 ARMYRDDITIIVVQFNSHVVGAYQNQE
:::::::::::::::::::::::::::
NP_001 ARMYRDDITIIVVQFNSHVVGAYQNQE
520 530
>>XP_011515438 (OMIM: 605993,608782) pyruvate dehyrogena (537 aa)
initn: 3637 init1: 3637 opt: 3637 Z-score: 3989.3 bits: 748.0 E(91774): 2e-215
Smith-Waterman score: 3637; 100.0% identity (100.0% similar) in 537 aa overlap (60-596:1-537)
30 40 50 60 70 80
pF1KE2 CDDRRMCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHK
::::::::::::::::::::::::::::::
XP_011 MPAPTQLFFPLIRNCELSRIYGTACYCHHK
10 20 30
90 100 110 120 130 140
pF1KE2 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCA
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE2 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFN
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE2 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFS
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE2 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHP
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE2 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYH
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE2 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGG
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE2 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEEL
460 470 480 490 500 510
570 580 590
pF1KE2 ARMYRDDITIIVVQFNSHVVGAYQNQE
:::::::::::::::::::::::::::
XP_011 ARMYRDDITIIVVQFNSHVVGAYQNQE
520 530
>>NP_001316862 (OMIM: 615499) [Pyruvate dehydrogenase [a (529 aa)
initn: 1357 init1: 586 opt: 1715 Z-score: 1882.4 bits: 358.2 E(91774): 4.4e-98
Smith-Waterman score: 1715; 54.4% identity (79.9% similar) in 472 aa overlap (126-592:61-525)
100 110 120 130 140 150
pF1KE2 SYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ---KFYLTPPQVNSILKANE
.. :..:: . .. :.: :.: .:.:.:
NP_001 VSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGE
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE2 YSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQ
. :. ..... .:.: :.:::: ::.:.::::..:.:::: :...:.::::.: ::.:
NP_001 TTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE2 AVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLR
:::::::::.::::. :.:: ..:.:.:: . :::::.: :::.: . :........ ::
NP_001 AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE2 TYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGAT
.:::::.::. ....:::. .:.:::.::::: :. . : :.:::::::
NP_001 VYWQELLDLHM--EMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGAT
220 230 240 250 260
340 350 360 370 380 390
pF1KE2 ACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSE
::.:::::. :::::.:: ::.:::::..: :: . :. :::: :. :: ::: :::.::
NP_001 ACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESE
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE2 AKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPP
.... .:::::.:.: ::::::..::: .::. ..: : . : : .: ::.:.:::
NP_001 DRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIY-QFTPPHYYTPP
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE2 YLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVR-IVGEYLTGMHHQQPIAVGGYK
:::::::::::::::::::::::.::::. . .:::: .::. . :. .:
NP_001 YLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLA--QRP
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE2 VTLGQMHGLLTERRTKMSSVFE-DQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELA
..:: :..:: .: : :.. : ::::::.:::::.::::.: .. :::. ::.:::.::
NP_001 ANLGLMQSLLLQR--KASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLA
450 460 470 480 490 500
580 590
pF1KE2 RMYRDDITIIVVQFNSHVVGAYQNQE
::::::::. :: :::. .:::
NP_001 RMYRDDITVTVVYFNSESIGAYYKGG
510 520
>>NP_001316863 (OMIM: 615499) [Pyruvate dehydrogenase [a (529 aa)
initn: 1357 init1: 586 opt: 1715 Z-score: 1882.4 bits: 358.2 E(91774): 4.4e-98
Smith-Waterman score: 1715; 54.4% identity (79.9% similar) in 472 aa overlap (126-592:61-525)
100 110 120 130 140 150
pF1KE2 SYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ---KFYLTPPQVNSILKANE
.. :..:: . .. :.: :.: .:.:.:
NP_001 VSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGE
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE2 YSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQ
. :. ..... .:.: :.:::: ::.:.::::..:.:::: :...:.::::.: ::.:
NP_001 TTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE2 AVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLR
:::::::::.::::. :.:: ..:.:.:: . :::::.: :::.: . :........ ::
NP_001 AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE2 TYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGAT
.:::::.::. ....:::. .:.:::.::::: :. . : :.:::::::
NP_001 VYWQELLDLHM--EMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGAT
220 230 240 250 260
340 350 360 370 380 390
pF1KE2 ACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSE
::.:::::. :::::.:: ::.:::::..: :: . :. :::: :. :: ::: :::.::
NP_001 ACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESE
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE2 AKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPP
.... .:::::.:.: ::::::..::: .::. ..: : . : : .: ::.:.:::
NP_001 DRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIY-QFTPPHYYTPP
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE2 YLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVR-IVGEYLTGMHHQQPIAVGGYK
:::::::::::::::::::::::.::::. . .:::: .::. . :. .:
NP_001 YLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLA--QRP
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE2 VTLGQMHGLLTERRTKMSSVFE-DQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELA
..:: :..:: .: : :.. : ::::::.:::::.::::.: .. :::. ::.:::.::
NP_001 ANLGLMQSLLLQR--KASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLA
450 460 470 480 490 500
580 590
pF1KE2 RMYRDDITIIVVQFNSHVVGAYQNQE
::::::::. :: :::. .:::
NP_001 RMYRDDITVTVVYFNSESIGAYYKGG
510 520
>>NP_065837 (OMIM: 615499) [Pyruvate dehydrogenase [acet (529 aa)
initn: 1357 init1: 586 opt: 1715 Z-score: 1882.4 bits: 358.2 E(91774): 4.4e-98
Smith-Waterman score: 1715; 54.4% identity (79.9% similar) in 472 aa overlap (126-592:61-525)
100 110 120 130 140 150
pF1KE2 SYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQ---KFYLTPPQVNSILKANE
.. :..:: . .. :.: :.: .:.:.:
NP_065 VSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGE
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE2 YSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQ
. :. ..... .:.: :.:::: ::.:.::::..:.:::: :...:.::::.: ::.:
NP_065 TTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE2 AVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLR
:::::::::.::::. :.:: ..:.:.:: . :::::.: :::.: . :........ ::
NP_065 AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE2 TYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGAT
.:::::.::. ....:::. .:.:::.::::: :. . : :.:::::::
NP_065 VYWQELLDLHM--EMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGAT
220 230 240 250 260
340 350 360 370 380 390
pF1KE2 ACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSE
::.:::::. :::::.:: ::.:::::..: :: . :. :::: :. :: ::: :::.::
NP_065 ACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESE
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE2 AKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPP
.... .:::::.:.: ::::::..::: .::. ..: : . : : .: ::.:.:::
NP_065 DRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIY-QFTPPHYYTPP
330 340 350 360 370 380
460 470 480 490 500 510
pF1KE2 YLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVR-IVGEYLTGMHHQQPIAVGGYK
:::::::::::::::::::::::.::::. . .:::: .::. . :. .:
NP_065 YLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLA--QRP
390 400 410 420 430 440
520 530 540 550 560 570
pF1KE2 VTLGQMHGLLTERRTKMSSVFE-DQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELA
..:: :..:: .: : :.. : ::::::.:::::.::::.: .. :::. ::.:::.::
NP_065 ANLGLMQSLLLQR--KASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLA
450 460 470 480 490 500
580 590
pF1KE2 RMYRDDITIIVVQFNSHVVGAYQNQE
::::::::. :: :::. .:::
NP_065 RMYRDDITVTVVYFNSESIGAYYKGG
510 520
596 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:42:44 2019 done: Tue Jul 16 15:42:45 2019
Total Scan time: 5.180 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]