Result of FASTA (omim) for
pF1KE0544
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0544, 427 aa
1>>>pF1KE0544 427 - 427 aa - 427 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5391+/-0.000402; mu= 15.2608+/- 0.025
mean_var=68.3118+/-13.446, 0's: 0 Z-trim(111.9): 17 B-trim: 35 in 1/51
Lambda= 0.155177
statistics sampled from 20634 (20642) to 20634 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.242), width: 16
Scan time: 6.600
The best scores are: opt bits E(85289)
NP_000346 (OMIM: 275350,613441) transcobalamin-2 i ( 427) 2837 644.6 1.5e-184
NP_001171655 (OMIM: 275350,613441) transcobalamin- ( 400) 1877 429.6 6.8e-120
NP_001053 (OMIM: 189905) transcobalamin-1 precurso ( 433) 452 110.6 7.9e-24
XP_011543241 (OMIM: 261000,609342) PREDICTED: gast ( 403) 314 79.7 1.5e-14
NP_005133 (OMIM: 261000,609342) gastric intrinsic ( 417) 261 67.9 5.7e-11
>>NP_000346 (OMIM: 275350,613441) transcobalamin-2 isofo (427 aa)
initn: 2837 init1: 2837 opt: 2837 Z-score: 3434.5 bits: 644.6 E(85289): 1.5e-184
Smith-Waterman score: 2837; 99.8% identity (99.8% similar) in 427 aa overlap (1-427:1-427)
10 20 30 40 50 60
pF1KE0 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 GNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
NP_000 GNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI
370 380 390 400 410 420
pF1KE0 ELRLVSW
:::::::
NP_000 ELRLVSW
>>NP_001171655 (OMIM: 275350,613441) transcobalamin-2 is (400 aa)
initn: 1874 init1: 1874 opt: 1877 Z-score: 2273.4 bits: 429.6 E(85289): 6.8e-120
Smith-Waterman score: 2580; 93.4% identity (93.4% similar) in 427 aa overlap (1-427:1-400)
10 20 30 40 50 60
pF1KE0 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRAN-----
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL
: :::::::::::::::::::::::::::::::::::::
NP_001 ------------W----------HDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL
120 130 140 150
190 200 210 220 230 240
pF1KE0 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE0 GNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
NP_001 GNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE0 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE0 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI
340 350 360 370 380 390
pF1KE0 ELRLVSW
:::::::
NP_001 ELRLVSW
400
>>NP_001053 (OMIM: 189905) transcobalamin-1 precursor [H (433 aa)
initn: 389 init1: 132 opt: 452 Z-score: 548.8 bits: 110.6 E(85289): 7.9e-24
Smith-Waterman score: 484; 29.4% identity (59.0% similar) in 446 aa overlap (4-423:10-429)
10 20 30 40 50
pF1KE0 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSI
.: .:: . . . : :.::. : . .. : . .. . .: .
NP_001 MRQSHQLPLVGLLLFSF-IPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVN--V
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 YVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLAL--
..:.: ..: : . .....: . .. : .: : :.::: .:::
NP_001 VLSLKLVGIQIQTLMQKMIQQIKYNVKSRL---------SDV----SSGELALIILALGV
60 70 80 90 100
120 130 140 150 160
pF1KE0 --RANCEFVRG-HKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQK
:. ... : :.: .... .:. . :.: : :.::: .: .::::: .
NP_001 CRNAEENLIYDYHLIDKLENKFQAEIENMEA-----HNGTPLTNYYQLSLDVLALCLFNG
110 120 130 140 150
170 180 190 200 210 220
pF1KE0 RVHDS-VVDKLLYAVEPFHQGHH-SVDTAAMAGLAFTCLKRSNFN------PGRRQRITM
. ::... . .. : . ::::.::: ::.::.:.: .: : . :..
NP_001 NYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE0 AIRTVREEILKAQTPEGHFGNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDG
... :.::. . .: .::..:: :.: :..: : : .. ..:. ...:
NP_001 YTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQG
220 230 240 250 260 270
290 300 310 320 330
pF1KE0 AFQNALMISQLLPVLNHKTYIDLIFPD--CLAPRVML-----EPAAETIPQTQEIISVTL
::.: .:.::.: ::..: : : :.. . :: . : :..: :::.
NP_001 AFSNPNAAAQVLPALMGKTFLD-INKDSSCVSASGNFNISADEPITVTPPDSQSYISVNY
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE0 QVLSLLPPYRQSISVLAGSTVEDVLKKAHELG----GFTYETQASLSGPYLTSVMGKAAG
.: . : ...:: ::. .:..::.... :::.: .. :::.: ..: :.
NP_001 SV-RINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERS--WGPYITCIQGLCAN
340 350 360 370 380 390
400 410 420
pF1KE0 --EREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
.: .:.:: . . :: :: ..: ..::..:.:
NP_001 NNDRTYWELL-SGGEPLSQGAGSYVVRNGENLEVRWSKY
400 410 420 430
>>XP_011543241 (OMIM: 261000,609342) PREDICTED: gastric (403 aa)
initn: 161 init1: 65 opt: 314 Z-score: 382.3 bits: 79.7 E(85289): 1.5e-14
Smith-Waterman score: 379; 27.8% identity (57.1% similar) in 431 aa overlap (8-420:6-396)
10 20 30 40 50
pF1KE0 MRHLGAFLFLLGVL----GALTEM---CEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPS
:.::..: :. :. : .: . ::. : ..: . : . :::
XP_011 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVN--GIQVLMENSVTSSAYPNPS
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 IYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALR
: ... : ::. ..:: :. : . .: :..: ..:::.: ..::
XP_011 ILIAMNL----AGA------YNLKA--QKLLTYQLMSSDNNDL----TIGQLGLTIMALT
60 70 80 90 100
120 130 140 150 160 170
pF1KE0 ANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHD
..:. ::. :: :. .:. . . . ...: .:.::::: .....
XP_011 SSCR----DPGDK-VSILQRQMEN----WAPSSPNAEASAFYGPSLAILALCQKNSEATL
110 120 130 140 150
180 190 200 210 220
pF1KE0 SVVDK----LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRS---NFNPGRRQRITMAIRTV
.. . :: ::. :::.::: ::.::. . . . : :. . .... .
XP_011 PIAVRFAKTLLANSSPFN-----VDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDI
160 170 180 190 200
230 240 250 260 270 280
pF1KE0 REEILKAQTPEGHFGNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNA
:.: .: .:..::: ::.: : ..: :. . . : :. .: ...: :.:
XP_011 VEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWN-CKKTTDMILNEIKQGKFHNP
210 220 230 240 250 260
290 300 310 320 330 340
pF1KE0 LMISQLLPVL-NHKTYIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQ
. :.:.:: : .:. .. .:. .: :.. . . :. :. . ::
XP_011 MSIAQILPSLKDHE--VQPTLPSNPGP----GPTSASNITVIYTINNQLRGVELLFNETI
270 280 290 300 310
350 360 370 380 390 400
pF1KE0 SISVLAGSTVEDVLKKAHELGG-FTYETQASLSGPYLTSV--MGKAAGEREFWQLLRDPN
..:: .::.. ::..:.. . : .:: . : ..:. ... .... .::.:
XP_011 NVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGV-
320 330 340 350 360 370
410 420
pF1KE0 TPLLQGIADYRPKDGETIELRLVSW
::: .:.::: : . : :
XP_011 TPLNEGVADYIPFNHEHITANFTQY
380 390 400
>>NP_005133 (OMIM: 261000,609342) gastric intrinsic fact (417 aa)
initn: 193 init1: 65 opt: 261 Z-score: 318.0 bits: 67.9 E(85289): 5.7e-11
Smith-Waterman score: 405; 28.2% identity (56.4% similar) in 440 aa overlap (8-420:6-410)
10 20 30 40 50
pF1KE0 MRHLGAFLFLLGVL----GALTEM---CEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPS
:.::..: :. :. : .: . ::. : ..: . : . :::
NP_005 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVN--GIQVLMENSVTSSAYPNPS
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 IYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALR
: ... : ::. ..:: :. : . .: :..: ..:::.: ..::
NP_005 ILIAMNL----AGA------YNLKA--QKLLTYQLMSSDNNDL----TIGQLGLTIMALT
60 70 80 90 100
120 130 140 150 160 170
pF1KE0 ANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHD
..:. ::. :: :. .:. . . . ...: .:.::::: .....
NP_005 SSCR----DPGDK-VSILQRQMEN----WAPSSPNAEASAFYGPSLAILALCQKNSEATL
110 120 130 140 150
180 190 200 210 220
pF1KE0 SVVDK----LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRS---NFNPGRRQRITMAIRTV
.. . :: ::. :::.::: ::.::. . . . : :. . .... .
NP_005 PIAVRFAKTLLANSSPFN-----VDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDI
160 170 180 190 200
230 240 250 260 270 280
pF1KE0 REEILKAQTPEGHFGNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNA
:.: .: .:..::: ::.: : ..: :. . . : :. .: ...: :.:
NP_005 VEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWN-CKKTTDMILNEIKQGKFHNP
210 220 230 240 250 260
290 300 310 320 330
pF1KE0 LMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIP----QTQEIISVTLQV------
. :.:.:: :. :::.:. : .: ..:. . : . :.: .
NP_005 MSIAQILPSLKGKTYLDVPQVTC-SPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRG
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE0 LSLLPPYRQSISVLAGSTVEDVLKKAHELGG-FTYETQASLSGPYLTSV--MGKAAGERE
. :: ..:: .::.. ::..:.. . : .:: . : ..:. ... ....
NP_005 VELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKT
330 340 350 360 370 380
400 410 420
pF1KE0 FWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
.::.: ::: .:.::: : . : :
NP_005 YWQFLSGV-TPLNEGVADYIPFNHEHITANFTQY
390 400 410
427 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:04:59 2016 done: Thu Nov 3 00:05:00 2016
Total Scan time: 6.600 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]