Result of FASTA (omim) for
pF1KE0495
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0495, 207 aa
1>>>pF1KE0495 207 - 207 aa - 207 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3901+/-0.000338; mu= 12.6070+/- 0.021
mean_var=60.7740+/-12.085, 0's: 0 Z-trim(114.8): 31 B-trim: 3 in 1/54
Lambda= 0.164519
statistics sampled from 24860 (24891) to 24860 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.292), width: 16
Scan time: 5.200
The best scores are: opt bits E(85289)
XP_016884087 (OMIM: 123631,610425) PREDICTED: beta ( 207) 1495 363.0 1.9e-100
XP_006724203 (OMIM: 123631,610425) PREDICTED: beta ( 201) 1442 350.4 1.1e-96
NP_001877 (OMIM: 123631,610425) beta-crystallin A4 ( 196) 1418 344.7 5.8e-95
NP_005199 (OMIM: 123610,600881) beta-crystallin A3 ( 215) 1002 246.0 3.3e-65
XP_016879687 (OMIM: 123610,600881) PREDICTED: beta ( 316) 1002 246.1 4.7e-65
NP_476434 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 749 185.9 3.7e-47
NP_476435 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 749 185.9 3.7e-47
NP_001878 (OMIM: 600929,611544) beta-crystallin B1 ( 252) 566 142.6 5.4e-34
XP_011528201 (OMIM: 600929,611544) PREDICTED: beta ( 252) 566 142.6 5.4e-34
XP_006724204 (OMIM: 123620,601547) PREDICTED: beta ( 205) 512 129.7 3.3e-30
NP_000487 (OMIM: 123620,601547) beta-crystallin B2 ( 205) 512 129.7 3.3e-30
XP_011528202 (OMIM: 123620,601547) PREDICTED: beta ( 205) 512 129.7 3.3e-30
XP_011528204 (OMIM: 123630,609741) PREDICTED: beta ( 267) 507 128.6 9.4e-30
NP_004067 (OMIM: 123630,609741) beta-crystallin B3 ( 211) 499 126.6 2.8e-29
XP_005250009 (OMIM: 609603) PREDICTED: gamma-cryst ( 182) 395 101.9 6.7e-22
XP_011514138 (OMIM: 609603) PREDICTED: gamma-cryst ( 295) 395 102.0 1e-21
XP_016858891 (OMIM: 123670,615188) PREDICTED: gamm ( 177) 358 93.1 2.9e-19
XP_011514139 (OMIM: 609603) PREDICTED: gamma-cryst ( 260) 355 92.5 6.7e-19
NP_066269 (OMIM: 123680,604307) gamma-crystallin C ( 174) 351 91.5 9e-19
XP_011508964 (OMIM: 123680,604307) PREDICTED: gamm ( 174) 351 91.5 9e-19
NP_005201 (OMIM: 123670,615188) gamma-crystallin B ( 175) 323 84.8 9.1e-17
NP_653328 (OMIM: 609603) gamma-crystallin N isofor ( 182) 308 81.3 1.1e-15
XP_016865822 (OMIM: 601797) PREDICTED: absent in m (1544) 318 84.0 1.4e-15
NP_001615 (OMIM: 601797) absent in melanoma 1 prot (1723) 318 84.0 1.6e-15
XP_005266896 (OMIM: 601797) PREDICTED: absent in m (2131) 318 84.0 1.9e-15
NP_060011 (OMIM: 116100,123730) beta-crystallin S ( 178) 303 80.1 2.5e-15
XP_016884088 (OMIM: 123630,609741) PREDICTED: beta ( 169) 296 78.4 7.5e-15
XP_016867262 (OMIM: 609603) PREDICTED: gamma-cryst ( 125) 202 56.0 3e-08
NP_001295221 (OMIM: 609603) gamma-crystallin N iso ( 125) 202 56.0 3e-08
NP_055432 (OMIM: 123660) gamma-crystallin A [Homo ( 174) 177 50.2 2.4e-06
NP_008822 (OMIM: 115700,123690) gamma-crystallin D ( 174) 176 49.9 2.9e-06
>>XP_016884087 (OMIM: 123631,610425) PREDICTED: beta-cry (207 aa)
initn: 1495 init1: 1495 opt: 1495 Z-score: 1924.3 bits: 363.0 E(85289): 1.9e-100
Smith-Waterman score: 1495; 100.0% identity (100.0% similar) in 207 aa overlap (1-207:1-207)
10 20 30 40 50 60
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 FEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH
130 140 150 160 170 180
190 200
pF1KE0 SGDYKHFREWGSHAPTFQVQSIRRIQQ
:::::::::::::::::::::::::::
XP_016 SGDYKHFREWGSHAPTFQVQSIRRIQQ
190 200
>>XP_006724203 (OMIM: 123631,610425) PREDICTED: beta-cry (201 aa)
initn: 1442 init1: 1442 opt: 1442 Z-score: 1856.5 bits: 350.4 E(85289): 1.1e-96
Smith-Waterman score: 1442; 100.0% identity (100.0% similar) in 200 aa overlap (8-207:2-201)
10 20 30 40 50 60
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 FEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH
120 130 140 150 160 170
190 200
pF1KE0 SGDYKHFREWGSHAPTFQVQSIRRIQQ
:::::::::::::::::::::::::::
XP_006 SGDYKHFREWGSHAPTFQVQSIRRIQQ
180 190 200
>>NP_001877 (OMIM: 123631,610425) beta-crystallin A4 [Ho (196 aa)
initn: 1418 init1: 1418 opt: 1418 Z-score: 1825.9 bits: 344.7 E(85289): 5.8e-95
Smith-Waterman score: 1418; 100.0% identity (100.0% similar) in 196 aa overlap (12-207:1-196)
10 20 30 40 50 60
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
10 20 30 40
70 80 90 100 110 120
pF1KE0 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 FEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHH
110 120 130 140 150 160
190 200
pF1KE0 SGDYKHFREWGSHAPTFQVQSIRRIQQ
:::::::::::::::::::::::::::
NP_001 SGDYKHFREWGSHAPTFQVQSIRRIQQ
170 180 190
>>NP_005199 (OMIM: 123610,600881) beta-crystallin A3 [Ho (215 aa)
initn: 1002 init1: 1002 opt: 1002 Z-score: 1291.6 bits: 246.0 E(85289): 3.3e-65
Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (19-207:27-215)
10 20 30 40 50
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGF
: ::::....:...:::.: :::. ::.: : .:
NP_005 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 ETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACAN
..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: :::: ::
NP_005 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 HRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQ
:..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::::.:
NP_005 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
130 140 150 160 170 180
180 190 200
pF1KE0 YVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
:.::::::.:::::.::::::: : :.::::::::
NP_005 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
190 200 210
>>XP_016879687 (OMIM: 123610,600881) PREDICTED: beta-cry (316 aa)
initn: 1002 init1: 1002 opt: 1002 Z-score: 1288.9 bits: 246.1 E(85289): 4.7e-65
Smith-Waterman score: 1002; 68.3% identity (89.9% similar) in 189 aa overlap (19-207:128-316)
10 20 30 40
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVL
: ::::....:...:::.: :::. ::.:
XP_016 PPKRPHHSCVLCLPETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVS
100 110 120 130 140 150
50 60 70 80 90 100
pF1KE0 ELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPA
: .:..:::::: ::::.:.::..: :::.:::::::: ::::.:..:: ::: ::::
XP_016 ERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPI
160 170 180 190 200 210
110 120 130 140 150 160
pF1KE0 ACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGY
:::..:..::::.:::.:.. :.:::::::::::: .:::::....:::::: :.:::
XP_016 CSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGY
220 230 240 250 260 270
170 180 190 200
pF1KE0 RGFQYVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
::.::.::::::.:::::.::::::: : :.::::::::
XP_016 RGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
280 290 300 310
>>NP_476434 (OMIM: 115900,600836) beta-crystallin A2 [Ho (197 aa)
initn: 874 init1: 664 opt: 749 Z-score: 967.7 bits: 185.9 E(85289): 3.7e-47
Smith-Waterman score: 749; 54.5% identity (81.3% similar) in 187 aa overlap (22-207:11-197)
10 20 30 40 50
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELG-FETVRSLK
: ....:::. ::::: .. ..: .: : : . :::.:
NP_476 MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVK
10 20 30 40
60 70 80 90 100 110
pF1KE0 VLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLT
: .:.::.::. :::::.:::.:.:: :.::.:.... ...: ::::. :::: :::.:
NP_476 VENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 IFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDH
.:: .:: : : .: :::::: .::: ...:::..: ::::: :.:::::.::::: :.
NP_476 LFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDR
110 120 130 140 150 160
180 190 200
pF1KE0 HSGDYKHFREWGSHAPTFQVQSIRRIQQ
:::.. . : :..: : :.:::::.:.
NP_476 HSGEFCTYGELGTQAHTGQLQSIRRVQH
170 180 190
>>NP_476435 (OMIM: 115900,600836) beta-crystallin A2 [Ho (197 aa)
initn: 874 init1: 664 opt: 749 Z-score: 967.7 bits: 185.9 E(85289): 3.7e-47
Smith-Waterman score: 749; 54.5% identity (81.3% similar) in 187 aa overlap (22-207:11-197)
10 20 30 40 50
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELG-FETVRSLK
: ....:::. ::::: .. ..: .: : : . :::.:
NP_476 MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVK
10 20 30 40
60 70 80 90 100 110
pF1KE0 VLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLT
: .:.::.::. :::::.:::.:.:: :.::.:.... ...: ::::. :::: :::.:
NP_476 VENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 IFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDH
.:: .:: : : .: :::::: .::: ...:::..: ::::: :.:::::.::::: :.
NP_476 LFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDR
110 120 130 140 150 160
180 190 200
pF1KE0 HSGDYKHFREWGSHAPTFQVQSIRRIQQ
:::.. . : :..: : :.:::::.:.
NP_476 HSGEFCTYGELGTQAHTGQLQSIRRVQH
170 180 190
>>NP_001878 (OMIM: 600929,611544) beta-crystallin B1 [Ho (252 aa)
initn: 493 init1: 279 opt: 566 Z-score: 731.2 bits: 142.6 E(85289): 5.4e-34
Smith-Waterman score: 585; 42.1% identity (73.2% similar) in 209 aa overlap (3-206:35-233)
10 20
pF1KE0 MFPGPISEGATMTLQCTKSA----GPWKMVVW
:: .:. . .:.: : ...::.
NP_001 AKASASATVAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVF
10 20 30 40 50 60
30 40 50 60 70 80
pF1KE0 DEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSW
. ..::::: ::..:: .. . ::. :::. : .: ::.::...:.:...:::.:::: :
NP_001 ELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRW
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE0 DAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELS-DDYPSLQAMGWEG
..: ...: ..:: :::: . .. ....:: :: :. :.. :: ::: ..:. .
NP_001 NTW--SSSYRSDRLMSFRPIK-MDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGF-S
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE0 NEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
..::: .: ::.:: :.:::::.::.:: ::..:. :::. : :.::.::..
NP_001 DRVGSVKVSSGTWVGYQYPGYRGYQYLLE----PGDFRHWNEWGAFQP--QMQSLRRLRD
190 200 210 220 230
NP_001 KQWHLEGSFPVLATEPPK
240 250
>>XP_011528201 (OMIM: 600929,611544) PREDICTED: beta-cry (252 aa)
initn: 493 init1: 279 opt: 566 Z-score: 731.2 bits: 142.6 E(85289): 5.4e-34
Smith-Waterman score: 585; 42.1% identity (73.2% similar) in 209 aa overlap (3-206:35-233)
10 20
pF1KE0 MFPGPISEGATMTLQCTKSA----GPWKMVVW
:: .:. . .:.: : ...::.
XP_011 AKASASATVAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVF
10 20 30 40 50 60
30 40 50 60 70 80
pF1KE0 DEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSW
. ..::::: ::..:: .. . ::. :::. : .: ::.::...:.:...:::.:::: :
XP_011 ELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRW
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE0 DAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELS-DDYPSLQAMGWEG
..: ...: ..:: :::: . .. ....:: :: :. :.. :: ::: ..:. .
XP_011 NTW--SSSYRSDRLMSFRPIK-MDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGF-S
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE0 NEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ
..::: .: ::.:: :.:::::.::.:: ::..:. :::. : :.::.::..
XP_011 DRVGSVKVSSGTWVGYQYPGYRGYQYLLE----PGDFRHWNEWGAFQP--QMQSLRRLRD
190 200 210 220 230
XP_011 KQWHLEGSFPVLATEPPK
240 250
>>XP_006724204 (OMIM: 123620,601547) PREDICTED: beta-cry (205 aa)
initn: 477 init1: 237 opt: 512 Z-score: 663.4 bits: 129.7 E(85289): 3.3e-30
Smith-Waterman score: 531; 41.6% identity (75.8% similar) in 190 aa overlap (18-206:13-191)
10 20 30 40 50 60
pF1KE0 MFPGPISEGATMTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKV
.: .: :........:::. ::... ::.. : : : . :. :
XP_006 MASDHQTQAGKPQSLNP-KIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLV
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTI
.: :::.:.:. .:.:...:.:::: ::.: ... .. :.:.:: .. .. .. .
XP_006 QAGPWVGYEQANCKGEQFVFEKGEYPRWDSW--TSSRRTDSLSSLRPIK-VDSQEHKIIL
60 70 80 90 100 110
130 140 150 160 170
pF1KE0 FEQENFLGKKGEL-SDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDH
.:. :: ::: :. .:: ::..: :.. ..:.: .:.::.:: :.:::::.::.::
XP_006 YENPNFTGKKMEIIDDDVPSFHAHGYQ-EKVSSVRVQSGTWVGYQYPGYRGLQYLLE---
120 130 140 150 160
180 190 200
pF1KE0 HSGDYKHFREWGSHAPTFQVQSIRRIQQ
.:::: ..: :: ::::.:::.
XP_006 -KGDYKDSSDFG--APHPQVQSVRRIRDMQWHQRGAFHPSN
170 180 190 200
207 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:18:29 2016 done: Thu Nov 3 04:18:30 2016
Total Scan time: 5.200 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]