Result of FASTA (ccds) for
pF1KE0347
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0347, 853 aa
1>>>pF1KE0347 853 - 853 aa - 853 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6610+/-0.000955; mu= 15.3405+/- 0.058
mean_var=128.5572+/-25.242, 0's: 0 Z-trim(108.6): 30 B-trim: 38 in 1/51
Lambda= 0.113117
statistics sampled from 10284 (10302) to 10284 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.316), width: 16
Scan time: 4.460
The best scores are: opt bits E(32554)
CCDS13205.1 DNMT3B gene_id:1789|Hs108|chr20 ( 853) 5871 970.2 0
CCDS13206.1 DNMT3B gene_id:1789|Hs108|chr20 ( 833) 3339 557.0 4.8e-158
CCDS13204.1 DNMT3B gene_id:1789|Hs108|chr20 ( 845) 3339 557.0 4.9e-158
CCDS33157.1 DNMT3A gene_id:1788|Hs108|chr2 ( 912) 2711 454.6 3.7e-127
CCDS1718.2 DNMT3A gene_id:1788|Hs108|chr2 ( 723) 2709 454.2 3.9e-127
CCDS56184.1 DNMT3B gene_id:1789|Hs108|chr20 ( 694) 2603 436.8 6.1e-122
CCDS56183.1 DNMT3B gene_id:1789|Hs108|chr20 ( 728) 2603 436.9 6.3e-122
CCDS13207.1 DNMT3B gene_id:1789|Hs108|chr20 ( 770) 2603 436.9 6.5e-122
CCDS46650.1 DNMT3L gene_id:29947|Hs108|chr21 ( 386) 623 113.5 7.2e-25
CCDS13705.1 DNMT3L gene_id:29947|Hs108|chr21 ( 387) 623 113.5 7.2e-25
>>CCDS13205.1 DNMT3B gene_id:1789|Hs108|chr20 (853 aa)
initn: 5871 init1: 5871 opt: 5871 Z-score: 5183.8 bits: 970.2 E(32554): 0
Smith-Waterman score: 5871; 100.0% identity (100.0% similar) in 853 aa overlap (1-853:1-853)
10 20 30 40 50 60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
790 800 810 820 830 840
850
pF1KE0 HLFAPLKDYFACE
:::::::::::::
CCDS13 HLFAPLKDYFACE
850
>>CCDS13206.1 DNMT3B gene_id:1789|Hs108|chr20 (833 aa)
initn: 5736 init1: 3338 opt: 3339 Z-score: 2950.8 bits: 557.0 E(32554): 4.8e-158
Smith-Waterman score: 5700; 97.7% identity (97.7% similar) in 853 aa overlap (1-853:1-833)
10 20 30 40 50 60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
310 320 330 340 350
370 380 390 400 410 420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
:::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
360 370 380 390 400
430 440 450 460 470 480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
770 780 790 800 810 820
850
pF1KE0 HLFAPLKDYFACE
:::::::::::::
CCDS13 HLFAPLKDYFACE
830
>>CCDS13204.1 DNMT3B gene_id:1789|Hs108|chr20 (845 aa)
initn: 5736 init1: 3338 opt: 3339 Z-score: 2950.7 bits: 557.0 E(32554): 4.9e-158
Smith-Waterman score: 5700; 97.7% identity (97.7% similar) in 853 aa overlap (1-853:13-845)
10 20 30 40
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRG
::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MEPSPEPPSLESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 RRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 NSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 NSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 DLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 VWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 VWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 LATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 LATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGL
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 KPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGK
::::::: :::::::::::::::::::::::::::::::::
CCDS13 KPNNTQP--------------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGK
370 380 390 400
410 420 430 440 450 460
pF1KE0 DRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYM
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE0 YDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCL
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE0 PQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGY
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE0 LVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 LVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGG
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE0 SPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKR
650 660 670 680 690 700
710 720 730 740 750 760
pF1KE0 DISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKL
710 720 730 740 750 760
770 780 790 800 810 820
pF1KE0 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQK
770 780 790 800 810 820
830 840 850
pF1KE0 LLGRSWSVPVIRHLFAPLKDYFACE
:::::::::::::::::::::::::
CCDS13 LLGRSWSVPVIRHLFAPLKDYFACE
830 840
>>CCDS33157.1 DNMT3A gene_id:1788|Hs108|chr2 (912 aa)
initn: 2812 init1: 2281 opt: 2711 Z-score: 2396.4 bits: 454.6 E(32554): 3.7e-127
Smith-Waterman score: 2802; 51.0% identity (71.9% similar) in 861 aa overlap (12-852:80-911)
10 20 30 40
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAI
.:.:. : .: :: .: .: :.
CCDS33 RPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASE--LLPNGDLEKRSEPQPE--EG-
50 60 70 80 90 100
50 60 70 80 90
pF1KE0 RTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMP-KLFRETRTRS--
.: :..... . .. : .. . .: .: .:. : .:: .:
CCDS33 -SPA-GGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMK
110 120 130 140 150 160
100 110 120 130 140 150
pF1KE0 -ESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPV-EFPAT--RSLRRRATASA
:. : :.. . : :.:: :: : .... :. : : ...: . :
CCDS33 MEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIA
170 180 190 200 210 220
160 170 180 190 200 210
pF1KE0 G---TPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGD
: . . :. .. . . . : . ..: .: . : .. . .: ..
CCDS33 GMNAVEENQGPGESQKVE--EASPPAVQQPTDPASP--TVATTPEPVGSDAGDKNATKAG
230 240 250 260 270
220 230 240 250 260 270
pF1KE0 GDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSE
: ::.::. ::::.:::::..::::::. .::: :.. .: : :::.::::::::
CCDS33 DDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSV
280 290 300 310 320 330
280 290 300 310 320
pF1KE0 VSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP----SSPGDS---
: ..::. :. : . :. ::.:: ::::.:..:. : :::: :: :. .:.
CCDS33 VCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKA
340 350 360 370 380 390
330 340 350 360 370 380
pF1KE0 LEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTA
.: : :::.::: :::.:.: .::.: : .:. . : : .
CCDS33 VEVQNKPMIEWALGGFQPSGPKGLEP----PEEEKNPYK------------EVYTDMWVE
400 410 420 430 440
390 400 410 420 430 440
pF1KE0 DDSATSDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGRK
..:. : : : : . : . : ...::... .: .. ..:: :.:::
CCDS33 PEAAA--YAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSL
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE0 NPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCV
: . :::: ::.::.:.. ::: :.:::::::::::.:: :::.:.:.:..:::::::
CCDS33 NVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCV
510 520 530 540 550 560
510 520 530 540 550 560
pF1KE0 ECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAP
::...::: :.: : ..::.:::: . .:.::::.:: ::: ::... :.. :
CCDS33 ECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPP
570 580 590 600 610 620
570 580 590 600 610 620
pF1KE0 KLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGN
:.:: .:: .:.:::::::::::::: ::::.:::.: .:.::::::.::.:: :.:.:.
CCDS33 KVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGK
630 640 650 660 670 680
630 640 650 660 670 680
pF1KE0 IKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNY
: ::.:::..:.:.:.:::::::::::::::::: ::::::::::::::::::::.::.
CCDS33 IMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHD
690 700 710 720 730 740
690 700 710 720 730 740
pF1KE0 SRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPG
.::::::::::::.::::::: :.:::::::::: ::::::: .::::::::::::::::
CCDS33 ARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPG
750 760 770 780 790 800
750 760 770 780 790 800
pF1KE0 MNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLW
::::. .. :::::::.:::..::::..::.::::.::::::::.: ::: :: :::.::
CCDS33 MNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILW
810 820 830 840 850 860
810 820 830 840 850
pF1KE0 CTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
:::.::.:::::::::::::.: :::.:::::::::::::::::::.::::
CCDS33 CTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
870 880 890 900 910
>>CCDS1718.2 DNMT3A gene_id:1788|Hs108|chr2 (723 aa)
initn: 2812 init1: 2281 opt: 2709 Z-score: 2396.0 bits: 454.2 E(32554): 3.9e-127
Smith-Waterman score: 2790; 59.1% identity (78.6% similar) in 682 aa overlap (181-852:61-722)
160 170 180 190 200 210
pF1KE0 TASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSG
: . ..: .: . : .. . .: ..
CCDS17 VIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASP--TVATTPEPVGSDAGDKNATKA
40 50 60 70 80
220 230 240 250 260 270
pF1KE0 DGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFS
: ::.::. ::::.:::::..::::::. .::: :.. .: : :::.::::::::
CCDS17 GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFS
90 100 110 120 130 140
280 290 300 310 320
pF1KE0 EVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP----SSPGDS--
: ..::. :. : . :. ::.:: ::::.:..:. : :::: :: :. .:.
CCDS17 VVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAK
150 160 170 180 190 200
330 340 350 360 370 380
pF1KE0 -LEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRT
.: : :::.::: :::.:.: .::.: : .:. . : : .
CCDS17 AVEVQNKPMIEWALGGFQPSGPKGLEP----PEEEKNPYK------------EVYTDMWV
210 220 230 240 250
390 400 410 420 430 440
pF1KE0 ADDSATSDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGR
..:. : : : : . : . : ...::... .: .. ..:: :.:::
CCDS17 EPEAAA--YAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGS
260 270 280 290 300 310
450 460 470 480 490 500
pF1KE0 KNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFC
: . :::: ::.::.:.. ::: :.:::::::::::.:: :::.:.:.:..::::::
CCDS17 LNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFC
320 330 340 350 360 370
510 520 530 540 550 560
pF1KE0 VECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEA
:::...::: :.: : ..::.:::: . .:.::::.:: ::: ::... :..
CCDS17 VECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDP
380 390 400 410 420 430
570 580 590 600 610 620
pF1KE0 PKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEG
::.:: .:: .:.:::::::::::::: ::::.:::.: .:.::::::.::.:: :.:.:
CCDS17 PKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQG
440 450 460 470 480 490
630 640 650 660 670 680
pF1KE0 NIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLN
.: ::.:::..:.:.:.:::::::::::::::::: ::::::::::::::::::::.::.
CCDS17 KIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLH
500 510 520 530 540 550
690 700 710 720 730 740
pF1KE0 YSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLP
.::::::::::::.::::::: :.:::::::::: ::::::: .:::::::::::::::
CCDS17 DARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLP
560 570 580 590 600 610
750 760 770 780 790 800
pF1KE0 GMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVL
:::::. .. :::::::.:::..::::..::.::::.::::::::.: ::: :: :::.:
CCDS17 GMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDIL
620 630 640 650 660 670
810 820 830 840 850
pF1KE0 WCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
::::.::.:::::::::::::.: :::.:::::::::::::::::::.::::
CCDS17 WCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
680 690 700 710 720
>>CCDS56184.1 DNMT3B gene_id:1789|Hs108|chr20 (694 aa)
initn: 4050 init1: 2602 opt: 2603 Z-score: 2302.8 bits: 436.8 E(32554): 6.1e-122
Smith-Waterman score: 4474; 81.4% identity (81.4% similar) in 853 aa overlap (1-853:1-694)
10 20 30 40 50 60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
::::::::
CCDS56 SSLLSYTQ----------------------------------------------------
130 140 150 160 170 180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
::::::::::::::::::::::::::::::::::::
CCDS56 ------------------------SLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
70 80 90 100
190 200 210 220 230 240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
230 240 250 260 270
370 380 390 400 410 420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
:::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
280 290 300 310 320
430 440 450 460 470 480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
330 340 350 360 370 380
490 500 510 520 530 540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
390 400 410 420 430 440
550 560 570 580 590 600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
450 460 470 480 490 500
610 620 630 640 650 660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
510 520 530 540 550 560
670 680 690 700 710 720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
570 580 590 600 610 620
730 740 750 760 770 780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
::::::::::::::::::::::::
CCDS56 IDAIKVSAAHRARYFWGNLPGMNR------------------------------------
630 640
790 800 810 820 830 840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
:::::::::::::::::::::::::::::::::
CCDS56 ---------------------------IFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
650 660 670 680
850
pF1KE0 HLFAPLKDYFACE
:::::::::::::
CCDS56 HLFAPLKDYFACE
690
>>CCDS56183.1 DNMT3B gene_id:1789|Hs108|chr20 (728 aa)
initn: 4044 init1: 2602 opt: 2603 Z-score: 2302.5 bits: 436.9 E(32554): 6.3e-122
Smith-Waterman score: 4775; 85.3% identity (85.3% similar) in 853 aa overlap (1-853:1-728)
10 20 30 40 50 60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
::::::::::::::::::::::::::::::::::::::::::
CCDS56 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPA------------------
70 80 90 100
130 140 150 160 170 180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
::::::::::::::::::::::::::::::::::::
CCDS56 ------------------------SLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
110 120 130
190 200 210 220 230 240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
:::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
320 330 340 350
430 440 450 460 470 480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
360 370 380 390 400 410
490 500 510 520 530 540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
420 430 440 450 460 470
550 560 570 580 590 600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
480 490 500 510 520 530
610 620 630 640 650 660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
540 550 560 570 580 590
670 680 690 700 710 720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
600 610 620 630 640 650
730 740 750 760 770 780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
::::::::::::::::::::::::
CCDS56 IDAIKVSAAHRARYFWGNLPGMNR------------------------------------
660 670 680
790 800 810 820 830 840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
:::::::::::::::::::::::::::::::::
CCDS56 ---------------------------IFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
690 700 710
850
pF1KE0 HLFAPLKDYFACE
:::::::::::::
CCDS56 HLFAPLKDYFACE
720
>>CCDS13207.1 DNMT3B gene_id:1789|Hs108|chr20 (770 aa)
initn: 5000 init1: 2602 opt: 2603 Z-score: 2302.2 bits: 436.9 E(32554): 6.5e-122
Smith-Waterman score: 5154; 90.3% identity (90.3% similar) in 853 aa overlap (1-853:1-770)
10 20 30 40 50 60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
310 320 330 340 350
370 380 390 400 410 420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
:::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
360 370 380 390 400
430 440 450 460 470 480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
::::::::::::::::::::::::
CCDS13 IDAIKVSAAHRARYFWGNLPGMNR------------------------------------
710 720
790 800 810 820 830 840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
:::::::::::::::::::::::::::::::::
CCDS13 ---------------------------IFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
730 740 750
850
pF1KE0 HLFAPLKDYFACE
:::::::::::::
CCDS13 HLFAPLKDYFACE
760 770
>>CCDS46650.1 DNMT3L gene_id:29947|Hs108|chr21 (386 aa)
initn: 820 init1: 522 opt: 623 Z-score: 559.9 bits: 113.5 E(32554): 7.2e-25
Smith-Waterman score: 885; 37.8% identity (65.4% similar) in 376 aa overlap (417-791:35-371)
390 400 410 420 430 440
pF1KE0 SATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSF
:. .: .: :. ..:: :. :: . .
CCDS46 PALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQ
10 20 30 40 50 60
450 460 470 480 490 500
pF1KE0 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV
:::::::.: :.:.::. ...::::::::::..:: :. ::.:.: .: ::.: ::..
CCDS46 HPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDS
70 80 90 100 110 120
510 520 530 540 550 560
pF1KE0 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAP-KLYP
::: ::..... . : ::.:::. :.:.::. : .:.::. : : : ...
CCDS46 LVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDR----ESENPLEMFE
130 140 150 160 170 180
570 580 590 600 610 620
pF1KE0 AIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYV
..:. ::.:.::::::. : ::: ..: .. : :. :..:.:
CCDS46 TVPVWRRQPVRVLSLFEDIK------KEL-TSLG-FLES---------GS--DPGQLKHV
190 200 210 220
630 640 650 660 670 680
pF1KE0 NDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPK
:: . ..:..::::::::: :..: :... . : .:.:..::.:.:::
CCDS46 VDVTDTVRKDVEEWGPFDLVYGATP--PLGHTCDRPPSWY------LFQFHRLLQYARPK
230 240 250 260 270
690 700 710 720 730 740
pF1KE0 EGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRP
:. ::::::: . .... : ::::: .:: : .. .. . : :.:. :
CCDS46 PGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNI-----P
280 290 300 310 320
750 760 770 780 790 800
pF1KE0 VIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTEL
.: :.. : .. : . .:. :. . ...: . : :: ..:.
CCDS46 AIRSRHWALVSEE--ELSLLAQNKQSSKLAAKWPT-KLVKNCFLPLREYFKYFSTELTSS
330 340 350 360 370 380
810 820 830 840 850
pF1KE0 ERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
CCDS46 L
>>CCDS13705.1 DNMT3L gene_id:29947|Hs108|chr21 (387 aa)
initn: 892 init1: 522 opt: 623 Z-score: 559.9 bits: 113.5 E(32554): 7.2e-25
Smith-Waterman score: 886; 37.5% identity (65.7% similar) in 376 aa overlap (417-791:35-372)
390 400 410 420 430 440
pF1KE0 SATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSF
:. .: .: :. ..:: :. :: . .
CCDS13 PALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQ
10 20 30 40 50 60
450 460 470 480 490 500
pF1KE0 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV
:::::::.: :.:.::. ...::::::::::..:: :. ::.:.: .: ::.: ::..
CCDS13 HPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDS
70 80 90 100 110 120
510 520 530 540 550 560
pF1KE0 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAP-KLYP
::: ::..... . : ::.:::. :.:.::. : .:.::. : : : ...
CCDS13 LVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDR----ESENPLEMFE
130 140 150 160 170 180
570 580 590 600 610 620
pF1KE0 AIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYV
..:. ::.:.::::::. : ::: ..: .. : :. :..:.:
CCDS13 TVPVWRRQPVRVLSLFEDIK------KEL-TSLG-FLES---------GS--DPGQLKHV
190 200 210 220
630 640 650 660 670 680
pF1KE0 NDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPK
:: . ..:..::::::::: :..: :... . : .:.:..::.:.:::
CCDS13 VDVTDTVRKDVEEWGPFDLVYGATP--PLGHTCDRPPSWY------LFQFHRLLQYARPK
230 240 250 260 270
690 700 710 720 730 740
pF1KE0 EGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRP
:. ::::::: . .... : ::::: .:: : .. .. . : :.:.:..
CCDS13 PGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIR--
280 290 300 310 320 330
750 760 770 780 790 800
pF1KE0 VIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTEL
.:.. : .. : . .:. :. . ...: . : :: ..:.
CCDS13 --SSRHWALVSEE--ELSLLAQNKQSSKLAAKWPT-KLVKNCFLPLREYFKYFSTELTSS
340 350 360 370 380
810 820 830 840 850
pF1KE0 ERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
CCDS13 L
853 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:54:04 2016 done: Thu Nov 3 14:54:04 2016
Total Scan time: 4.460 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]