Result of FASTA (omim) for
pF1KE0344
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0344, 707 aa
1>>>pF1KE0344 707 - 707 aa - 707 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5116+/-0.000338; mu= 19.3083+/- 0.021
mean_var=80.2967+/-15.841, 0's: 0 Z-trim(116.0): 19 B-trim: 0 in 0/52
Lambda= 0.143128
statistics sampled from 26782 (26801) to 26782 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.314), width: 16
Scan time: 10.660
The best scores are: opt bits E(85289)
XP_016879064 (OMIM: 246650,611761) PREDICTED: lipa ( 534) 407 93.9 1.7e-18
XP_011520916 (OMIM: 246650,611761) PREDICTED: lipa ( 540) 407 93.9 1.7e-18
NP_073610 (OMIM: 246650,611761) lipase maturation ( 567) 407 94.0 1.8e-18
XP_006720992 (OMIM: 246650,611761) PREDICTED: lipa ( 434) 349 81.9 5.8e-15
XP_016879066 (OMIM: 246650,611761) PREDICTED: lipa ( 434) 349 81.9 5.8e-15
XP_006720991 (OMIM: 246650,611761) PREDICTED: lipa ( 458) 349 81.9 6.1e-15
XP_016879065 (OMIM: 246650,611761) PREDICTED: lipa ( 489) 349 81.9 6.4e-15
XP_016879070 (OMIM: 246650,611761) PREDICTED: lipa ( 285) 326 77.0 1.1e-13
XP_011520920 (OMIM: 246650,611761) PREDICTED: lipa ( 312) 326 77.0 1.2e-13
XP_011520917 (OMIM: 246650,611761) PREDICTED: lipa ( 408) 323 76.5 2.3e-13
XP_011520919 (OMIM: 246650,611761) PREDICTED: lipa ( 350) 288 69.2 3e-11
XP_016879068 (OMIM: 246650,611761) PREDICTED: lipa ( 350) 288 69.2 3e-11
XP_016879069 (OMIM: 246650,611761) PREDICTED: lipa ( 350) 288 69.2 3e-11
XP_016879067 (OMIM: 246650,611761) PREDICTED: lipa ( 355) 284 68.4 5.4e-11
>>XP_016879064 (OMIM: 246650,611761) PREDICTED: lipase m (534 aa)
initn: 543 init1: 177 opt: 407 Z-score: 453.0 bits: 93.9 E(85289): 1.7e-18
Smith-Waterman score: 676; 29.6% identity (54.2% similar) in 561 aa overlap (6-554:51-508)
10 20 30
pF1KE0 MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYG
: : ..:...: :.. :: . : : :
XP_016 GYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIG
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE0 PEGILPARRTLRP-----QGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
.:.:: : :. : . :. . ::.:: : ..:.::.::: ..
XP_016 DRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDWS--DMNSNLDLLALLGLGIS-
90 100 110 120 130
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :
XP_016 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLS---
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCL
. :: : . .: :::.::.:...:..:. . :: : :: . .::::: .
XP_016 RLPQ-----HTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPM
200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITG
:.:.:.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:
XP_016 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE0 NYNFFNLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAY
: .:.: .:.: . : .:: :::..:. .
XP_016 NLSFLNWLTMVPSLACFDD------------------------ATLGFLFPSGP------
310 320 330
330 340 350 360 370 380
pF1KE0 GTVHYFGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQ
:... :.. :: : : . .:.. .. . .: ::: :.:
XP_016 GSLKDRVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW-----------
340 350 360 370
390 400 410 420 430 440
pF1KE0 VRGWLRKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLA
::. : :.:... : .:: :.. :...
XP_016 -------LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIV
380 390 400
450 460 470 480 490 500
pF1KE0 NSYGLFRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPR
:.:: : .: : ::.:.:. ... : . :: :::. :: : .. :.. :
XP_016 NTYGAFGSITKE--RAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYR
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE0 LDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFHKQPPTYVRAQRYK
::: :::::. . :. :. :. .:: . .. :. :. :: .::
XP_016 LDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLL----AHNPFAGRPPPSPLEVAGT
470 480 490 500 510
570 580 590 600 610 620
pF1KE0 YWFSQPGEQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANSTLAQAL
XP_016 EQSLDCPPLPCAISRRF
520 530
>>XP_011520916 (OMIM: 246650,611761) PREDICTED: lipase m (540 aa)
initn: 505 init1: 177 opt: 407 Z-score: 453.0 bits: 93.9 E(85289): 1.7e-18
Smith-Waterman score: 618; 29.8% identity (54.2% similar) in 520 aa overlap (6-513:51-471)
10 20 30
pF1KE0 MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYG
: : ..:...: :.. :: . : : :
XP_011 GYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIG
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE0 PEGILPARRTLRP-----QGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
.:.:: : :. : . :. . ::.:: : ..:.::.::: ..
XP_011 DRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDWS--DMNSNLDLLALLGLGIS-
90 100 110 120 130
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :.
XP_011 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLSR--
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCL
:: : . .: :::.::.:...:..:. . :: : :: . .::::: .
XP_011 -LPQHT-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPM
200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITG
:.:.:.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:
XP_011 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE0 NYNFFNLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAY
: .:.: .:.: . : .:: :::..:. .
XP_011 NLSFLNWLTMVPSLACFDD------------------------ATLGFLFPSGP------
310 320 330
330 340 350 360 370 380
pF1KE0 GTVHYFGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQ
:... :.. :: : : . .:.. .. . .: ::: :.:
XP_011 GSLKDRVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW-----------
340 350 360 370
390 400 410 420 430 440
pF1KE0 VRGWLRKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLA
::. : :.:... : .:: :.. :...
XP_011 -------LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIV
380 390 400
450 460 470 480 490 500
pF1KE0 NSYGLFRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPR
:.:: : .: : ::.:.:. ... : . :: :::. :: : .. :.. :
XP_011 NTYGAFGSITKE--RAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYR
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE0 LDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFHKQPPTYVRAQRYK
::: :::::.
XP_011 LDWLMWFAAFQLRRRRKDRLSPTAAASNDGSVAFQSGGRSQTLSQRTGKKESPGLGVAEA
470 480 490 500 510 520
>>NP_073610 (OMIM: 246650,611761) lipase maturation fact (567 aa)
initn: 596 init1: 177 opt: 407 Z-score: 452.7 bits: 94.0 E(85289): 1.8e-18
Smith-Waterman score: 792; 30.0% identity (54.9% similar) in 621 aa overlap (6-609:51-566)
10 20 30
pF1KE0 MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYG
: : ..:...: :.. :: . : : :
NP_073 GYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIG
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE0 PEGILPARRTLRP-----QGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
.:.:: : :. : . :. . ::.:: : ..:.::.::: ..
NP_073 DRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDWS--DMNSNLDLLALLGLGIS-
90 100 110 120 130
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :
NP_073 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLS---
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCL
. :: : . .: :::.::.:...:..:. . :: : :: . .::::: .
NP_073 RLPQHT-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPM
200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITG
:.:.:.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:
NP_073 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE0 NYNFFNLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAY
: .:.: .:.: . : .:: :::..:. .
NP_073 NLSFLNWLTMVPSLACFDD------------------------ATLGFLFP------SGP
310 320 330
330 340 350 360 370 380
pF1KE0 GTVHYFGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQ
:... :.. :: : : . .:.. .. . .: ::: :.:
NP_073 GSLKDRVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW-----------
340 350 360 370
390 400 410 420 430 440
pF1KE0 VRGWLRKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLA
::. : :.:... : .:: :.. :...
NP_073 -------LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIV
380 390 400
450 460 470 480 490 500
pF1KE0 NSYGLFRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPR
:.:: : .: : ::.:.:. ... : . :: :::. :: : .. :.. :
NP_073 NTYGAFGSITK--ERAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYR
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE0 LDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFH-KQPPTYVRAQRY
::: :::::. . :. :. :. .:: . .. :. :. :: . :: .::...:
NP_073 LDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLL----AHNPFAGRPPPRWVRGEHY
470 480 490 500 510
570 580 590 600 610
pF1KE0 KYWFSQPG----EQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANST
.: ::.:: .:.:: :. . .:: .:: . :. .:. : .:
NP_073 RYKFSRPGGRHAAEGKWWVRKRIGAYFPPLSLEE--LRPYFRDRGWPLPGPL
520 530 540 550 560
620 630 640 650 660 670
pF1KE0 LAQALHWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPAS
>>XP_006720992 (OMIM: 246650,611761) PREDICTED: lipase m (434 aa)
initn: 571 init1: 177 opt: 349 Z-score: 389.6 bits: 81.9 E(85289): 5.8e-15
Smith-Waterman score: 624; 30.0% identity (54.4% similar) in 496 aa overlap (126-609:40-433)
100 110 120 130 140 150
pF1KE0 SPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRKEAPQG
:.: :::::::.... :: :. ::
XP_006 SSLDVGAPGLPGPGHLETDGRTHDCRHLTGWESQLLETGFLGIFLCPLWTLSR---LPQH
10 20 30 40 50 60
160 170 180 190 200 210
pF1KE0 RQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCLPTPAA
: . .: :::.::.:...:..:. . :: : :: . .::::: .:.:.:
XP_006 T-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPMPNPVA
70 80 90 100 110
220 230 240 250 260 270
pF1KE0 WFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFF
.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:: .:.
XP_006 YYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFL
120 130 140 150 160 170
280 290 300 310 320 330
pF1KE0 NLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHY
: .:.: . : .:: :::..:. . :...
XP_006 NWLTMVPSLACFDD------------------------ATLGFLFPSGP------GSLKD
180 190 200
340 350 360 370 380 390
pF1KE0 FGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQVRGWL
:.. :: : : . .:.. .. . .: ::: :.:
XP_006 RVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW----------------
210 220 230 240
400 410 420 430 440 450
pF1KE0 RKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLANSYGL
::. : :.:... : .:: :.. :...:.::
XP_006 --LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIVNTYGA
250 260 270
460 470 480 490 500
pF1KE0 FRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQM
: .: : ::.:.:. ... : . :: :::. :: : .. :.. :::: :
XP_006 FGSITK--ERAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYRLDWLM
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE0 WFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFH-KQPPTYVRAQRYKYWFS
::::. . :. :. :. .:: . .. :. :. :: . :: .::...:.: ::
XP_006 WFAAFQTYEHNDWIIHLAGKLLASDAEALSLL----AHNPFAGRPPPRWVRGEHYRYKFS
340 350 360 370 380
570 580 590 600 610 620
pF1KE0 QPG----EQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANSTLAQAL
.:: .:.:: :. . .:: .:: . :. .:. : .:
XP_006 RPGGRHAAEGKWWVRKRIGAYFPPLSLEE--LRPYFRDRGWPLPGPL
390 400 410 420 430
630 640 650 660 670 680
pF1KE0 HWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPASQKDSG
>>XP_016879066 (OMIM: 246650,611761) PREDICTED: lipase m (434 aa)
initn: 571 init1: 177 opt: 349 Z-score: 389.6 bits: 81.9 E(85289): 5.8e-15
Smith-Waterman score: 624; 30.0% identity (54.4% similar) in 496 aa overlap (126-609:40-433)
100 110 120 130 140 150
pF1KE0 SPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRKEAPQG
:.: :::::::.... :: :. ::
XP_016 SSLDVGAPGLPGPGHLETDGRTHDCRHLTGWESQLLETGFLGIFLCPLWTLSR---LPQH
10 20 30 40 50 60
160 170 180 190 200 210
pF1KE0 RQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCLPTPAA
: . .: :::.::.:...:..:. . :: : :: . .::::: .:.:.:
XP_016 T-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPMPNPVA
70 80 90 100 110
220 230 240 250 260 270
pF1KE0 WFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFF
.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:: .:.
XP_016 YYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFL
120 130 140 150 160 170
280 290 300 310 320 330
pF1KE0 NLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHY
: .:.: . : .:: :::..:. . :...
XP_016 NWLTMVPSLACFDD------------------------ATLGFLFPSGP------GSLKD
180 190 200
340 350 360 370 380 390
pF1KE0 FGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQVRGWL
:.. :: : : . .:.. .. . .: ::: :.:
XP_016 RVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW----------------
210 220 230 240
400 410 420 430 440 450
pF1KE0 RKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLANSYGL
::. : :.:... : .:: :.. :...:.::
XP_016 --LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIVNTYGA
250 260 270
460 470 480 490 500
pF1KE0 FRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQM
: .: : ::.:.:. ... : . :: :::. :: : .. :.. :::: :
XP_016 FGSITK--ERAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYRLDWLM
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE0 WFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFH-KQPPTYVRAQRYKYWFS
::::. . :. :. :. .:: . .. :. :. :: . :: .::...:.: ::
XP_016 WFAAFQTYEHNDWIIHLAGKLLASDAEALSLL----AHNPFAGRPPPRWVRGEHYRYKFS
340 350 360 370 380
570 580 590 600 610 620
pF1KE0 QPG----EQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANSTLAQAL
.:: .:.:: :. . .:: .:: . :. .:. : .:
XP_016 RPGGRHAAEGKWWVRKRIGAYFPPLSLEE--LRPYFRDRGWPLPGPL
390 400 410 420 430
630 640 650 660 670 680
pF1KE0 HWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPASQKDSG
>>XP_006720991 (OMIM: 246650,611761) PREDICTED: lipase m (458 aa)
initn: 621 init1: 177 opt: 349 Z-score: 389.3 bits: 81.9 E(85289): 6.1e-15
Smith-Waterman score: 717; 30.1% identity (55.3% similar) in 561 aa overlap (61-609:2-457)
40 50 60 70 80 90
pF1KE0 PGLYGPEGILPARRTLRPQGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
::.:: : ..:.::.::: ..
XP_006 MPTILWLMDWS--DMNSNLDLLALLGLGIS-
10 20
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :.
XP_006 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLSR--
30 40 50 60 70 80
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCL
:: : . .: :::.::.:...:..:. . :: : :: . .::::: .
XP_006 -LPQHT-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPM
90 100 110 120 130
210 220 230 240 250 260
pF1KE0 PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITG
:.:.:.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:
XP_006 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSG
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE0 NYNFFNLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAY
: .:.: .:.: . : .:: :::..:. .
XP_006 NLSFLNWLTMVPSLACFDD------------------------ATLGFLFPSGP------
200 210 220
330 340 350 360 370 380
pF1KE0 GTVHYFGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQ
:... :.. :: : : . .:.. .. . .: ::: :.:
XP_006 GSLKDRVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW-----------
230 240 250 260
390 400 410 420 430 440
pF1KE0 VRGWLRKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLA
::. : :.:... : .:: :.. :...
XP_006 -------LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIV
270 280 290
450 460 470 480 490 500
pF1KE0 NSYGLFRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPR
:.:: : .: : ::.:.:. ... : . :: :::. :: : .. :.. :
XP_006 NTYGAFGSITK--ERAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYR
300 310 320 330 340 350
510 520 530 540 550 560
pF1KE0 LDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFH-KQPPTYVRAQRY
::: :::::. . :. :. :. .:: . .. :. :. :: . :: .::...:
XP_006 LDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLL----AHNPFAGRPPPRWVRGEHY
360 370 380 390 400
570 580 590 600 610
pF1KE0 KYWFSQPG----EQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANST
.: ::.:: .:.:: :. . .:: .:: . :. .:. : .:
XP_006 RYKFSRPGGRHAAEGKWWVRKRIGAYFPPLSLEE--LRPYFRDRGWPLPGPL
410 420 430 440 450
620 630 640 650 660 670
pF1KE0 LAQALHWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPAS
>>XP_016879065 (OMIM: 246650,611761) PREDICTED: lipase m (489 aa)
initn: 571 init1: 177 opt: 349 Z-score: 388.9 bits: 81.9 E(85289): 6.4e-15
Smith-Waterman score: 624; 30.0% identity (54.4% similar) in 496 aa overlap (126-609:95-488)
100 110 120 130 140 150
pF1KE0 SPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRKEAPQG
:.: :::::::.... :: :. ::
XP_016 SSLDVGAPGLPGPGHLETDGRTHDCRHLTGWESQLLETGFLGIFLCPLWTLSR---LPQH
70 80 90 100 110 120
160 170 180 190 200 210
pF1KE0 RQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCLPTPAA
: . .: :::.::.:...:..:. . :: : :: . .::::: .:.:.:
XP_016 T-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPMPNPVA
130 140 150 160 170
220 230 240 250 260 270
pF1KE0 WFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFF
.. :: : :.:.. .... .::. :: ..: :: . :.:.:...:..:: .:.
XP_016 YYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFL
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE0 NLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHY
: .:.: . : .:: :::..:. . :...
XP_016 NWLTMVPSLACFDD------------------------ATLGFLFPSGP------GSLKD
240 250 260
340 350 360 370 380 390
pF1KE0 FGLEVDWQQRTIHSRTTFTFHQFSQWLKTLTLPTVWLGVASLVWELLSALWRWTQVRGWL
:.. :: : : . .:.. .. . .: ::: :.:
XP_016 RVLQM---QRDI--RGARPEPRFGSVVRRAA--NVSLGVL-LAW----------------
270 280 290
400 410 420 430 440 450
pF1KE0 RKLSAVVQLSLVGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGAVEHLQLANSYGL
::. : :.:... : .:: :.. :...:.::
XP_016 --LSVPVVLNLLSSRQVM--------------NTH----------FNS---LHIVNTYGA
300 310 320 330
460 470 480 490 500
pF1KE0 FRRMTGLGGRPEVVLEGSYDGH------HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQM
: .: : ::.:.:. ... : . :: :::. :: : .. :.. :::: :
XP_016 FGSITK--ERAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYRLDWLM
340 350 360 370 380
510 520 530 540 550 560
pF1KE0 WFAALGPHTHSPWFTSLVLRLLQGKEPVIRLVQSQVARYPFH-KQPPTYVRAQRYKYWFS
::::. . :. :. :. .:: . .. :. :. :: . :: .::...:.: ::
XP_016 WFAAFQTYEHNDWIIHLAGKLLASDAEALSLL----AHNPFAGRPPPRWVRGEHYRYKFS
390 400 410 420 430 440
570 580 590 600 610 620
pF1KE0 QPG----EQGQWWRRQWVEEFFPSVSLGDPTLETLLRQFGLQEKSPPRTRSANSTLAQAL
.:: .:.:: :. . .:: .:: . :. .:. : .:
XP_016 RPGGRHAAEGKWWVRKRIGAYFPPLSLEE--LRPYFRDRGWPLPGPL
450 460 470 480
630 640 650 660 670 680
pF1KE0 HWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCSLRSSPLAPVSGEKRRPASQKDSG
>>XP_016879070 (OMIM: 246650,611761) PREDICTED: lipase m (285 aa)
initn: 223 init1: 136 opt: 326 Z-score: 366.5 bits: 77.0 E(85289): 1.1e-13
Smith-Waterman score: 360; 32.9% identity (57.7% similar) in 222 aa overlap (6-221:51-252)
10 20 30
pF1KE0 MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYG
: : ..:...: :.. :: . : : :
XP_016 GYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIG
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE0 PEGILPARRTLRP-----QGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
.:.:: : :. : . :. . ::.:: : ..:.::.::: ..
XP_016 DRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDWS--DMNSNLDLLALLGLGIS-
90 100 110 120 130
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :.
XP_016 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLSR--
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCL
:: : . .: :::.::.:...:..:. . :: : :: . .::: :
XP_016 -LPQH-----TPTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYE---L
200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITG
: :. .:
XP_016 P----WWEVGVPRPQRHRTVSLLWPFPRAQPTHVSSPSMQEGRRG
250 260 270 280
>>XP_011520920 (OMIM: 246650,611761) PREDICTED: lipase m (312 aa)
initn: 375 init1: 166 opt: 326 Z-score: 366.0 bits: 77.0 E(85289): 1.2e-13
Smith-Waterman score: 493; 33.8% identity (61.2% similar) in 263 aa overlap (6-262:51-299)
10 20 30
pF1KE0 MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYG
: : ..:...: :.. :: . : : :
XP_011 GYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIG
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE0 PEGILPARRTLRP-----QGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
.:.:: : :. : . :. . ::.:: : ..:.::.::: ..
XP_011 DRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDW--SDMNSNLDLLALLGLGIS-
90 100 110 120 130
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :.
XP_011 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLSR--
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQCL
:: : . .: :::.::.:...:..:. . :: : :: . .::::: .
XP_011 -LPQHT-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYETQPM
200 210 220 230 240
210 220 230 240 250 260
pF1KE0 PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITG
:.:.:.. :: : :.:.. .... .::. :: ..: :: . :.:.:
XP_011 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQCPGWGCV
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE0 NYNFFNLMTLVLTTALLDDQHLAAEPGHGSRKKTATSWPKALLATLSLLLELAVYGLLAY
XP_011 LPCAAL
310
>>XP_011520917 (OMIM: 246650,611761) PREDICTED: lipase m (408 aa)
initn: 252 init1: 136 opt: 323 Z-score: 361.0 bits: 76.5 E(85289): 2.3e-13
Smith-Waterman score: 361; 33.2% identity (58.2% similar) in 220 aa overlap (6-214:51-257)
10 20 30
pF1KE0 MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYG
: : ..:...: :.. :: . : : :
XP_011 GYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIG
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE0 PEGILPARRTLRP-----QGKGRWQQLWETPTLLWEAPRLGLDTAQGLELLSLLGALVAL
.:.:: : :. : . :. . ::.:: : ..:.::.::: ..
XP_011 DRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDWS--DMNSNLDLLALLGLGIS-
90 100 110 120 130
100 110 120 130 140 150
pF1KE0 GALLLSPLRHPVIYLLLWAAYLSACQVGQVFLYFQWDSLLLETGFLAVLVAPLRPASHRK
. .:.. . ... ::. :.: .::.:. : :.: :::::::.... :: :.
XP_011 SFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLSR--
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 EAPQGRQAGALPHEDLPFWLVRWLLFRLMFASGVVKLTS-RCPAWWGLTALTYHYETQ--
:: : . .: :::.::.:...:..:. . :: : :: . .::: .
XP_011 -LPQHT-----PTSRIVLWGFRWLIFRIMLGAGLIKIRGDRC--WRDLTCMDFHYEEKFA
200 210 220 230 240
210 220 230 240 250 260
pF1KE0 -CL--PTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVL
:. :::
XP_011 GCFLRSGPAAPPCPDPPFPWPRAECPSCTGTPGLACSMRHCHTHLTAHSQVSDPADAQSC
250 260 270 280 290 300
707 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:09:27 2016 done: Sat Nov 5 22:09:28 2016
Total Scan time: 10.660 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]