Result of FASTA (omim) for
pF1KE0209
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0209, 303 aa
1>>>pF1KE0209 303 - 303 aa - 303 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3131+/-0.000336; mu= 15.3827+/- 0.021
mean_var=71.9212+/-14.263, 0's: 0 Z-trim(115.0): 53 B-trim: 0 in 0/56
Lambda= 0.151233
statistics sampled from 25149 (25203) to 25149 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.296), width: 16
Scan time: 6.780
The best scores are: opt bits E(85289)
NP_001327 (OMIM: 603169) cathepsin Z preproprotein ( 303) 2187 486.3 3.3e-137
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 418 100.4 7.1e-21
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 305 75.7 1.4e-13
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 305 75.7 1.4e-13
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 305 75.7 1.4e-13
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 305 75.7 1.4e-13
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 305 75.7 1.4e-13
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 298 74.1 4.1e-13
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 298 74.1 4.1e-13
NP_004070 (OMIM: 116845) cathepsin S isoform 1 pre ( 331) 270 68.0 2.8e-11
NP_001186668 (OMIM: 116845) cathepsin S isoform 2 ( 281) 254 64.5 2.8e-10
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 241 61.6 1.8e-09
NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 236 60.5 3.4e-09
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 236 60.6 4.9e-09
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 236 60.6 4.9e-09
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 236 60.6 4.9e-09
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 236 60.6 4.9e-09
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 236 60.6 4.9e-09
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 236 60.6 4.9e-09
NP_000387 (OMIM: 265800,601105) cathepsin K prepro ( 329) 202 53.2 8.2e-07
NP_001325 (OMIM: 600550) cathepsin O preproprotein ( 321) 198 52.3 1.5e-06
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 193 51.2 2.8e-06
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 193 51.2 2.8e-06
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 189 50.1 3.2e-06
NP_001306066 (OMIM: 116820) pro-cathepsin H isofor ( 201) 190 50.4 3.4e-06
XP_016877441 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 185 49.5 9.9e-06
XP_005254238 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 185 49.5 9.9e-06
XP_016877440 (OMIM: 116820) PREDICTED: pro-catheps ( 317) 185 49.5 1e-05
NP_004381 (OMIM: 116820) pro-cathepsin H isoform a ( 335) 185 49.5 1.1e-05
XP_011543630 (OMIM: 603539,615362) PREDICTED: cath ( 424) 160 44.1 0.00058
NP_003784 (OMIM: 603539,615362) cathepsin F precur ( 484) 160 44.1 0.00065
XP_016866234 (OMIM: 606749) PREDICTED: tubulointer ( 438) 157 43.5 0.00094
NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 147 41.2 0.0036
XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 147 41.2 0.0036
XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 147 41.3 0.004
NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 147 41.3 0.0042
NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 147 41.3 0.0045
XP_016866237 (OMIM: 606749) PREDICTED: tubulointer ( 309) 140 39.6 0.0093
>>NP_001327 (OMIM: 603169) cathepsin Z preproprotein [Ho (303 aa)
initn: 2187 init1: 2187 opt: 2187 Z-score: 2584.4 bits: 486.3 E(85289): 3.3e-137
Smith-Waterman score: 2187; 100.0% identity (100.0% similar) in 303 aa overlap (1-303:1-303)
10 20 30 40 50 60
pF1KE0 MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
250 260 270 280 290 300
pF1KE0 PIV
:::
NP_001 PIV
>>NP_001805 (OMIM: 170650,245000,245010,602365) dipeptid (463 aa)
initn: 279 init1: 131 opt: 418 Z-score: 495.8 bits: 100.4 E(85289): 7.1e-21
Smith-Waterman score: 418; 33.8% identity (60.1% similar) in 228 aa overlap (62-279:231-445)
40 50 60 70 80 90
pF1KE0 TCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGS
:: ::::::: :.:..: .::: :::
NP_001 MIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQ---ASCGS
210 220 230 240 250
100 110 120 130 140
pF1KE0 CWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGN-AGSCEGGND-LSVWDYAHQHGI
:.. :: . . :: : ... . .:: :.:..:.. : .:::: : . ::.. :.
NP_001 CYSFASMGMLEARIRILTNNSQ-TPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGL
260 270 280 290 300 310
150 160 170 180 190 200
pF1KE0 PDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYAN
.:.: : . :. : ..: :. . .: :: . . .. : :. .
NP_001 VEEACFPYTGTDSPCKMKEDC-----FRYYSSEYHY----VGGFYGGCNEALMKLELVHH
320 330 340 350 360
210 220 230 240 250 260
pF1KE0 GPISCGIMATERLANYTGGIYAE------YQDTTYINHVVSVAGWGI--SDGTEYWIVRN
::.. .. . . . .: ::: . .. ::.: ..:.: ..: .::::.:
NP_001 GPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKN
370 380 390 400 410 420
270 280 290 300
pF1KE0 SWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
::: ::: :..:: .:
NP_001 SWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
430 440 450 460
>>NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 247 init1: 110 opt: 305 Z-score: 364.6 bits: 75.7 E(85289): 1.4e-13
Smith-Waterman score: 329; 33.2% identity (57.6% similar) in 229 aa overlap (63-275:115-314)
40 50 60 70 80 90
pF1KE0 CYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSC
:.: :::. .:.. ..:: ::::
NP_001 SEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREK---GYVTPVKNQG---QCGSC
90 100 110 120 130
100 110 120 130 140
pF1KE0 WAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQH-
:: ..:.:. .. ... : : :: ::..:: :: : :.:: . ::: :.
NP_001 WAFSATGALEGQM-FRKTGRLIS--LSEQNLVDCSGPQGNEG-CNGG----LMDYAFQYV
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE0 ----GIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREK-M
:. .: :.: .. : :.: ... : : . .. .:: .
NP_001 QDNGGLDSEESYPYEATEESC-KYNPK---------YSVANDT-----GFVDIPKQEKAL
200 210 220 230
210 220 230 240 250
pF1KE0 MAEIYANGPISCGIMAT-ERLANYTGGIYAEYQDTTY-INHVVSVAGWGI----SDGTEY
: . . :::: .: : : . : ::: : . .. ..: : :.:.:. ::...:
NP_001 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
260 270 280 290 300
pF1KE0 WIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
:.:.::::: :: :....
NP_001 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 247 init1: 110 opt: 305 Z-score: 364.6 bits: 75.7 E(85289): 1.4e-13
Smith-Waterman score: 329; 33.2% identity (57.6% similar) in 229 aa overlap (63-275:115-314)
40 50 60 70 80 90
pF1KE0 CYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSC
:.: :::. .:.. ..:: ::::
NP_666 SEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREK---GYVTPVKNQG---QCGSC
90 100 110 120 130
100 110 120 130 140
pF1KE0 WAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQH-
:: ..:.:. .. ... : : :: ::..:: :: : :.:: . ::: :.
NP_666 WAFSATGALEGQM-FRKTGRLIS--LSEQNLVDCSGPQGNEG-CNGG----LMDYAFQYV
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE0 ----GIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREK-M
:. .: :.: .. : :.: ... : : . .. .:: .
NP_666 QDNGGLDSEESYPYEATEESC-KYNPK---------YSVANDT-----GFVDIPKQEKAL
200 210 220 230
210 220 230 240 250
pF1KE0 MAEIYANGPISCGIMAT-ERLANYTGGIYAEYQDTTY-INHVVSVAGWGI----SDGTEY
: . . :::: .: : : . : ::: : . .. ..: : :.:.:. ::...:
NP_666 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
260 270 280 290 300
pF1KE0 WIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
:.:.::::: :: :....
NP_666 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 247 init1: 110 opt: 305 Z-score: 364.6 bits: 75.7 E(85289): 1.4e-13
Smith-Waterman score: 329; 33.2% identity (57.6% similar) in 229 aa overlap (63-275:115-314)
40 50 60 70 80 90
pF1KE0 CYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSC
:.: :::. .:.. ..:: ::::
NP_001 SEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREK---GYVTPVKNQG---QCGSC
90 100 110 120 130
100 110 120 130 140
pF1KE0 WAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQH-
:: ..:.:. .. ... : : :: ::..:: :: : :.:: . ::: :.
NP_001 WAFSATGALEGQM-FRKTGRLIS--LSEQNLVDCSGPQGNEG-CNGG----LMDYAFQYV
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE0 ----GIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREK-M
:. .: :.: .. : :.: ... : : . .. .:: .
NP_001 QDNGGLDSEESYPYEATEESC-KYNPK---------YSVANDT-----GFVDIPKQEKAL
200 210 220 230
210 220 230 240 250
pF1KE0 MAEIYANGPISCGIMAT-ERLANYTGGIYAEYQDTTY-INHVVSVAGWGI----SDGTEY
: . . :::: .: : : . : ::: : . .. ..: : :.:.:. ::...:
NP_001 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
260 270 280 290 300
pF1KE0 WIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
:.:.::::: :: :....
NP_001 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 247 init1: 110 opt: 305 Z-score: 364.6 bits: 75.7 E(85289): 1.4e-13
Smith-Waterman score: 329; 33.2% identity (57.6% similar) in 229 aa overlap (63-275:115-314)
40 50 60 70 80 90
pF1KE0 CYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSC
:.: :::. .:.. ..:: ::::
NP_001 SEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREK---GYVTPVKNQG---QCGSC
90 100 110 120 130
100 110 120 130 140
pF1KE0 WAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQH-
:: ..:.:. .. ... : : :: ::..:: :: : :.:: . ::: :.
NP_001 WAFSATGALEGQM-FRKTGRLIS--LSEQNLVDCSGPQGNEG-CNGG----LMDYAFQYV
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE0 ----GIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREK-M
:. .: :.: .. : :.: ... : : . .. .:: .
NP_001 QDNGGLDSEESYPYEATEESC-KYNPK---------YSVANDT-----GFVDIPKQEKAL
200 210 220 230
210 220 230 240 250
pF1KE0 MAEIYANGPISCGIMAT-ERLANYTGGIYAEYQDTTY-INHVVSVAGWGI----SDGTEY
: . . :::: .: : : . : ::: : . .. ..: : :.:.:. ::...:
NP_001 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
260 270 280 290 300
pF1KE0 WIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
:.:.::::: :: :....
NP_001 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L1 is (333 aa)
initn: 247 init1: 110 opt: 305 Z-score: 364.6 bits: 75.7 E(85289): 1.4e-13
Smith-Waterman score: 329; 33.2% identity (57.6% similar) in 229 aa overlap (63-275:115-314)
40 50 60 70 80 90
pF1KE0 CYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSC
:.: :::. .:.. ..:: ::::
XP_005 SEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREK---GYVTPVKNQG---QCGSC
90 100 110 120 130
100 110 120 130 140
pF1KE0 WAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQH-
:: ..:.:. .. ... : : :: ::..:: :: : :.:: . ::: :.
XP_005 WAFSATGALEGQM-FRKTGRLIS--LSEQNLVDCSGPQGNEG-CNGG----LMDYAFQYV
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE0 ----GIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREK-M
:. .: :.: .. : :.: ... : : . .. .:: .
XP_005 QDNGGLDSEESYPYEATEESC-KYNPK---------YSVANDT-----GFVDIPKQEKAL
200 210 220 230
210 220 230 240 250
pF1KE0 MAEIYANGPISCGIMAT-ERLANYTGGIYAEYQDTTY-INHVVSVAGWGI----SDGTEY
: . . :::: .: : : . : ::: : . .. ..: : :.:.:. ::...:
XP_005 MKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKY
240 250 260 270 280 290
260 270 280 290 300
pF1KE0 WIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
:.:.::::: :: :....
XP_005 WLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001188504 (OMIM: 603308) cathepsin L2 preproprotein (334 aa)
initn: 273 init1: 106 opt: 298 Z-score: 356.3 bits: 74.1 E(85289): 4.1e-13
Smith-Waterman score: 346; 31.0% identity (57.5% similar) in 261 aa overlap (27-275:88-315)
10 20 30 40 50
pF1KE0 MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEY
::. . :.: . . .. : .
NP_001 MIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQK------FRKGKVFREPLF
60 70 80 90 100 110
60 70 80 90 100 110
pF1KE0 LSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPST
: ::::: :::. : :.. ..:: . :::::: ..:.:. .. ... : :
NP_001 L---DLPKSVDWRK-KG--YVTPVKNQ---KQCGSCWAFSATGALEGQM-FRKTGKLVS-
120 130 140 150 160
120 130 140 150 160 170
pF1KE0 LLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQHG-IPDETCNNYQAKDQECDKFNQCG
:: ::..:: :: : :.:: ...:....: . .: : : :. :
NP_001 -LSEQNLVDCSRPQGNQG-CNGGFMARAFQYVKENGGLDSEESYPYVAVDEIC-------
170 180 190 200 210
180 190 200 210 220
pF1KE0 TCNEFKECHAIRNYTLWRVGDYGSLSGREK-MMAEIYANGPISCGIMATER-LANYTGGI
... ... : : . : :.:: .: . . :::: .. : . . : .::
NP_001 ---KYRPENSVANDTGFTV----VAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGI
220 230 240 250 260
230 240 250 260 270 280
pF1KE0 YAEYQ-DTTYINHVVSVAGWGI----SDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGK
: : . .. ..: : :.:.:. :....::.:.:::: :: :...:
NP_001 YFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCG
270 280 290 300 310 320
290 300
pF1KE0 GARYNLAIEEHCTFGDPIV
NP_001 IATAASYPNV
330
>>NP_001324 (OMIM: 603308) cathepsin L2 preproprotein [H (334 aa)
initn: 273 init1: 106 opt: 298 Z-score: 356.3 bits: 74.1 E(85289): 4.1e-13
Smith-Waterman score: 346; 31.0% identity (57.5% similar) in 261 aa overlap (27-275:88-315)
10 20 30 40 50
pF1KE0 MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEY
::. . :.: . . .. : .
NP_001 MIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQK------FRKGKVFREPLF
60 70 80 90 100 110
60 70 80 90 100 110
pF1KE0 LSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPST
: ::::: :::. : :.. ..:: . :::::: ..:.:. .. ... : :
NP_001 L---DLPKSVDWRK-KG--YVTPVKNQ---KQCGSCWAFSATGALEGQM-FRKTGKLVS-
120 130 140 150 160
120 130 140 150 160 170
pF1KE0 LLSVQNVIDC----GNAGSCEGGNDLSVWDYAHQHG-IPDETCNNYQAKDQECDKFNQCG
:: ::..:: :: : :.:: ...:....: . .: : : :. :
NP_001 -LSEQNLVDCSRPQGNQG-CNGGFMARAFQYVKENGGLDSEESYPYVAVDEIC-------
170 180 190 200 210
180 190 200 210 220
pF1KE0 TCNEFKECHAIRNYTLWRVGDYGSLSGREK-MMAEIYANGPISCGIMATER-LANYTGGI
... ... : : . : :.:: .: . . :::: .. : . . : .::
NP_001 ---KYRPENSVANDTGFTV----VAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGI
220 230 240 250 260
230 240 250 260 270 280
pF1KE0 YAEYQ-DTTYINHVVSVAGWGI----SDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGK
: : . .. ..: : :.:.:. :....::.:.:::: :: :...:
NP_001 YFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCG
270 280 290 300 310 320
290 300
pF1KE0 GARYNLAIEEHCTFGDPIV
NP_001 IATAASYPNV
330
>>NP_004070 (OMIM: 116845) cathepsin S isoform 1 preprop (331 aa)
initn: 309 init1: 148 opt: 270 Z-score: 323.4 bits: 68.0 E(85289): 2.8e-11
Smith-Waterman score: 370; 33.9% identity (60.3% similar) in 224 aa overlap (62-275:115-312)
40 50 60 70 80 90
pF1KE0 TCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGS
:: : ::: . . .:. .. . ::.
NP_004 SEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWR-----EKGCVTEVKYQGS-CGA
90 100 110 120 130
100 110 120 130 140
pF1KE0 CWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC-----GNAGSCEGGNDLSVWDYA-H
::: ....:. ....: : : ::.::..:: :: : :.:: ....:
NP_004 CWAFSAVGALEAQLKLKT-GKLVS--LSAQNLVDCSTEKYGNKG-CNGGFMTTAFQYIID
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE0 QHGIPDETCNNYQAKDQEC--DKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMM
..:: ... :.: ::.: :. . .::... : :: :: ..
NP_004 NKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTEL------------PYG----REDVL
200 210 220 230
210 220 230 240 250 260
pF1KE0 AEIYAN-GPISCGIMATE-RLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRN
: :: ::.: :. : . . : .:.: : . : .:: : :.:.: .: :::.:.:
NP_004 KEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKN
240 250 260 270 280 290
270 280 290 300
pF1KE0 SWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
:::. .::.:..:.
NP_004 SWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
300 310 320 330
303 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 21:11:49 2016 done: Thu Nov 3 21:11:50 2016
Total Scan time: 6.780 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]