Result of FASTA (omim) for
pF1KE0196
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0196, 416 aa
1>>>pF1KE0196 416 - 416 aa - 416 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5415+/-0.00042; mu= 15.1518+/- 0.026
mean_var=62.5068+/-12.839, 0's: 0 Z-trim(109.4): 311 B-trim: 1055 in 1/50
Lambda= 0.162222
statistics sampled from 17304 (17627) to 17304 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.559), E-opt: 0.2 (0.207), width: 16
Scan time: 7.640
The best scores are: opt bits E(85289)
NP_001107859 (OMIM: 611704) transmembrane protease ( 418) 1122 271.7 2.4e-72
NP_872412 (OMIM: 611704) transmembrane protease se ( 421) 1113 269.6 1e-71
NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 1095 265.4 1.9e-70
NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 1077 261.2 3.5e-69
XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 1017 247.1 4.9e-65
XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 882 215.5 1.4e-55
XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 805 197.5 3e-50
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 737 181.6 3.4e-45
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 727 179.3 1.7e-44
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 714 176.2 1e-43
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 684 169.2 1.6e-41
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 684 169.2 1.8e-41
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 684 169.2 2e-41
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 684 169.2 2e-41
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 684 169.3 2.1e-41
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 666 165.0 3.4e-40
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 660 163.6 8.2e-40
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 660 163.6 8.9e-40
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 651 161.5 2.8e-39
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 649 161.0 3.6e-39
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 649 161.0 4.7e-39
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 649 161.0 4.9e-39
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 649 161.0 5.1e-39
NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 649 161.0 5.1e-39
NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 649 161.0 5.2e-39
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 645 160.1 8e-39
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 645 160.1 8e-39
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 644 159.9 1.8e-38
XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 641 159.2 2e-38
XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 641 159.2 2e-38
XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 641 159.2 2.1e-38
XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 641 159.2 2.1e-38
XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 641 159.2 2.1e-38
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 644 160.0 2.6e-38
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 644 160.0 2.7e-38
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 642 159.5 2.8e-38
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 640 159.0 2.8e-38
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 642 159.5 2.8e-38
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 637 158.2 3.6e-38
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 637 158.2 3.6e-38
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 641 159.3 4e-38
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 641 159.3 4.1e-38
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 641 159.3 4.1e-38
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 641 159.3 4.2e-38
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 641 159.3 4.2e-38
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 641 159.3 4.2e-38
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 641 159.3 4.2e-38
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 637 158.3 5.1e-38
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 637 158.3 5.2e-38
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 637 158.3 5.2e-38
>>NP_001107859 (OMIM: 611704) transmembrane protease ser (418 aa)
initn: 925 init1: 842 opt: 1122 Z-score: 1420.0 bits: 271.7 E(85289): 2.4e-72
Smith-Waterman score: 1122; 40.7% identity (73.3% similar) in 423 aa overlap (1-416:2-418)
10 20 30 40 50
pF1KE0 MYR---HGISSQRSWPLWTTIFIFLGVAAILGVTIGLLVHFLAVE-KTYYYQGDFHISG
::: : :. : ...: :... ...::::::::::. . : ::.:.:.:
NP_001 MMYRTVGFGTRSRNLKPWMIAVLIVLSLT-VVAVTIGLLVHFLVFDQKKEYYHGSFKILD
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 VTYNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQL
:.: .. . .: . :. . . : .:. :.:.:..:..: :. .: .:.. .
NP_001 PQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIM
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 KFKFPPAEGVSMRTKIKAKLHQMLKNNMASWNAVP---ASIKLMEISKAASEMLTNNCCG
:.:: .: ..: : :....:.... . :.: .:... .:....:. .. ::
NP_001 VFQFPSTEQRAVREK---KIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 RQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNN
..:. . :.:..: . ..:::::::.:. . : :::.:::. ::..::::: : .:
NP_001 KRVVPLNV--NRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SKDWTVNFGVVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLP
..:::.::. .: : : :.:. .:.::.: : . . :::.::.. .:.:.. ::.::::
NP_001 PHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 EAKMKLSENDNVVVTGWGTLYMNGSFPVILQEAFLKIIDNKICNASYAYSGFVTDSMLCA
::. ... : .: .::.:.::..: :.:: .:::.. .:. .:.. . .:.::
NP_001 EASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 GFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITS
:.: : :::..::::::. : .. :.:.:::::::.::.:.::::::.:: :::::.:
NP_001 GYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIAS
360 370 380 390 400 410
pF1KE0 KTGL
:::.
NP_001 KTGI
>>NP_872412 (OMIM: 611704) transmembrane protease serine (421 aa)
initn: 917 init1: 842 opt: 1113 Z-score: 1408.5 bits: 269.6 E(85289): 1e-71
Smith-Waterman score: 1113; 40.4% identity (73.0% similar) in 426 aa overlap (1-416:2-421)
10 20 30 40 50
pF1KE0 MYR---HGISSQRSWPLWTTIFIFLGVAAILGVTIGLLVHFLAVE-KTYYYQGDFHISG
::: : :. : ...: :... ...::::::::::. . : ::.:.:.:
NP_872 MMYRTVGFGTRSRNLKPWMIAVLIVLSLT-VVAVTIGLLVHFLVFDQKKEYYHGSFKILD
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 VTYNDNCENAASQASTNLSKDIE---TKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQ
:.: .. . .: . : ... . : .:. :.:.:..:..: :. .: .:.
NP_872 PQINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVD
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 LQLKFKFPPAEGVSMRTKIKAKLHQMLKNNMASWNAVP---ASIKLMEISKAASEMLTNN
. . :.:: .: ..: : :....:.... . :.: .:... .:....:. ..
NP_872 VIMVFQFPSTEQRAVREK---KIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 CCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAK
::..:. . :.:..: . ..:::::::.:. . : :::.:::. ::..::::: :
NP_872 SCGKRVVPLNV--NRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 KNNSKDWTVNFGVVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKI
.: ..:::.::. .: : : :.:. .:.::.: : . . :::.::.. .:.:.. ::.:
NP_872 YKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQI
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 CLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEAFLKIIDNKICNASYAYSGFVTDSM
:::::. ... : .: .::.:.::..: :.:: .:::.. .:. .:.. . .:
NP_872 CLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGM
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 LCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNW
.:::.: : :::..::::::. : .. :.:.:::::::.::.:.::::::.:: ::::
NP_872 FCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNW
360 370 380 390 400 410
410
pF1KE0 ITSKTGL
:.::::.
NP_872 IASKTGI
420
>>NP_054777 (OMIM: 610399) transmembrane protease serine (423 aa)
initn: 1000 init1: 874 opt: 1095 Z-score: 1385.7 bits: 265.4 E(85289): 1.9e-70
Smith-Waterman score: 1095; 40.0% identity (67.8% similar) in 423 aa overlap (1-416:2-423)
10 20 30 40 50
pF1KE0 MYRHGISSQRS---WPLWTTIFIFLGVAAILGVTIGLLVHFLAV--EKTYYYQGDFHIS
::: . :. : :. .... .:.: ::: ::.. .::: : . . ..
NP_054 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 GVTYNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQ
. ::. :..:. .:. . ::: .: . .:.:::.:::. . .: ...
NP_054 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 LKFKFPPAEGVSMRTKI-KAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNCCGR
: .: .: :: . ::. :.. .. .. : :.:. .:.:. .. :.:::
NP_054 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 QVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNS
. .... . .::.: :: ::::::.:: : : :::.::.. ::.::::::. .:
NP_054 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 KDWTVNFGVVVNKPYMTRKVQNIIFHENYSSPGLHD-DIALVQLAEEVSFTEYIRKICLP
::..:::... : : .. :: ::.:. :. :: ::.:..:. : .:. ....:::
NP_054 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPS-HDYDISLAELSSPVPYTNAVHRVCLP
250 260 270 280 290
300 310 320 330 340 350
pF1KE0 EAKMKLSENDNVVVTGWGTLYMNGSFPVILQEAFLKIIDNKICNASYAYSGFVTDSMLCA
.:..... .: . :::.:.: .: :..: . .:: :: ::. .: ::::
NP_054 DASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 GFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITS
: . :..::::.::::::. :.:.::.:.::::::: :.: ::::::::::. :.::::
NP_054 GSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITS
360 370 380 390 400 410
pF1KE0 KTGL
:::.
NP_054 KTGI
420
>>NP_004253 (OMIM: 605369) transmembrane protease serine (418 aa)
initn: 1013 init1: 819 opt: 1077 Z-score: 1363.1 bits: 261.2 E(85289): 3.5e-69
Smith-Waterman score: 1077; 39.0% identity (74.0% similar) in 420 aa overlap (1-416:1-418)
10 20 30 40 50
pF1KE0 MYRHG--ISSQRSWPLWTTIFIFLGVAAILGVTIGLLVHFLAVE-KTYYYQGDFHISGVT
::: . :..: ... :: .. ..::.:::.:::.::: . :.:.:...:.. .:
NP_004 MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 YNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQLKF
::.. .. :.: .:: ::. . ..:..:.. .......: :: ...: ... .::
NP_004 YNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 KFP-PAEGVSMRTKIKAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNCCGRQVA
.: .:.::...:.. :.::: :: .. . :.. ..::.. : :.: :
NP_004 QFTRNNNGASMKSRIESVLRQML-NNSGNLEINPSTEITSLTDQAAANWLINEC-GAGPD
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 NSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDW
.. ..:..: . ::.::::.:.. .. :.::.:::.. :.:.::::: ...: .::
NP_004 LITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 TVNFGVVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKM
.. :. .. : . .:.::..:.::.: ..:::::.: . :.::. :...::: : .
NP_004 IATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 KLSENDNVVVTGWGTLYMNGSFPVILQEAFLKIIDNKICNASYAYSGFVTDSMLCAGFMS
.. .... :::::. . : :... ..::.: .::: ..:.: . ..::::: .
NP_004 NIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 GEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKTGL
: .::::.::::::. ::: .: .:::::::: :: .:::::::::.: .:: ..::.
NP_004 GGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
360 370 380 390 400 410
>>XP_011530198 (OMIM: 610399) PREDICTED: transmembrane p (345 aa)
initn: 959 init1: 874 opt: 1017 Z-score: 1288.5 bits: 247.1 E(85289): 4.9e-65
Smith-Waterman score: 1017; 43.1% identity (71.7% similar) in 346 aa overlap (73-416:1-345)
50 60 70 80 90 100
pF1KE0 KTYYYQGDFHISGVTYNDNCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKL
.:. .:. . ::: .: . .:.:::.:::.
XP_011 MSQRLESMVKNAFYKSPLREEFVKSQVIKF
10 20 30
110 120 130 140 150 160
pF1KE0 LPNANGSNVQLQLKFKFPPAEGVSMRTKI-KAKLHQMLKNNMASWNAVPASIKLMEISKA
. .: ... : .: .: :: . ::. :.. .. .. : :.:. .:.:.
XP_011 SQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKT
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE0 ASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLL
.. :.::: . .... . .::.: :: ::::::.:: : : :::.::.. ::.
XP_011 ETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLV
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE0 SAAHCFAKKNNSKDWTVNFGVVVNKPYMTRKVQNIIFHENYSSPGLHD-DIALVQLAEEV
::::::. .: ::..:::... : : .. :: ::.:. :. :: ::.:..:. :
XP_011 SAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPS-HDYDISLAELSSPV
160 170 180 190 200
290 300 310 320 330 340
pF1KE0 SFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEAFLKIIDNKICNASYA
.:. ....:::.:..... .: . :::.:.: .: :..: . .:: :: :
XP_011 PYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQA
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE0 YSGFVTDSMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVY
:. .: ::::: . :..::::.::::::. :.:.::.:.::::::: :.: ::::::
XP_011 YNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVY
270 280 290 300 310 320
410
pF1KE0 TRVTSYRNWITSKTGL
::::. :.:::::::.
XP_011 TRVTALRDWITSKTGI
330 340
>>XP_005265767 (OMIM: 605369) PREDICTED: transmembrane p (301 aa)
initn: 860 init1: 810 opt: 882 Z-score: 1118.7 bits: 215.5 E(85289): 1.4e-55
Smith-Waterman score: 882; 41.9% identity (74.3% similar) in 303 aa overlap (115-416:1-301)
90 100 110 120 130 140
pF1KE0 FQNSSIYKEYVKSEVIKLLPNANGSNVQLQLKFKFP-PAEGVSMRTKIKAKLHQMLKNNM
.::.: .:.::...:.. :.::: ::
XP_005 MKFQFTRNNNGASMKSRIESVLRQML-NNS
10 20
150 160 170 180 190 200
pF1KE0 ASWNAVPASIKLMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQ
.. . :.. ..::.. : :.: : .. ..:..: . ::.::::.:..
XP_005 GNLEINPSTEITSLTDQAAANWLINEC-GAGPDLITLSEQRILGGTEAEEGSWPWQVSLR
30 40 50 60 70 80
210 220 230 240 250 260
pF1KE0 WKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGVVVNKPYMTRKVQNIIFHENYS
.. :.::.:::.. :.:.::::: ...: .:: .. :. .. : . .:.::..:.::.
XP_005 LNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYK
90 100 110 120 130 140
270 280 290 300 310 320
pF1KE0 SPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQ
: ..:::::.: . :.::. :...::: : ... .... :::::. . : :.
XP_005 SATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELR
150 160 170 180 190 200
330 340 350 360 370 380
pF1KE0 EAFLKIIDNKICNASYAYSGFVTDSMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVG
.. ..::.: .::: ..:.: . ..::::: .: .::::.::::::. ::: .: .::
XP_005 QGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVG
210 220 230 240 250 260
390 400 410
pF1KE0 IVSWGDGCGKKNKPGVYTRVTSYRNWITSKTGL
:::::: :: .:::::::::.: .:: ..::.
XP_005 IVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
270 280 290 300
>>XP_016864340 (OMIM: 605369) PREDICTED: transmembrane p (234 aa)
initn: 792 init1: 792 opt: 805 Z-score: 1023.1 bits: 197.5 E(85289): 3e-50
Smith-Waterman score: 805; 45.9% identity (78.1% similar) in 233 aa overlap (184-416:2-234)
160 170 180 190 200 210
pF1KE0 KLMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGAS
.:..: . ::.::::.:.. .. :.::.:
XP_016 MRILGGTEAEEGSWPWQVSLRLNNAHHCGGS
10 20 30
220 230 240 250 260 270
pF1KE0 LISSRWLLSAAHCFAKKNNSKDWTVNFGVVVNKPYMTRKVQNIIFHENYSSPGLHDDIAL
::.. :.:.::::: ...: .:: .. :. .. : . .:.::..:.::.: ..::::
XP_016 LINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIAL
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE0 VQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEAFLKIIDNK
:.: . :.::. :...::: : ... .... :::::. . : :... ..::.:
XP_016 VRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISND
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE0 ICNASYAYSGFVTDSMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGK
.::: ..:.: . ..::::: .: .::::.::::::. ::: .: .:::::::: ::
XP_016 VCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGL
160 170 180 190 200 210
400 410
pF1KE0 KNKPGVYTRVTSYRNWITSKTGL
.:::::::::.: .:: ..::.
XP_016 PDKPGVYTRVTAYLDWIRQQTGI
220 230
>>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa)
initn: 559 init1: 312 opt: 737 Z-score: 932.5 bits: 181.6 E(85289): 3.4e-45
Smith-Waterman score: 737; 32.2% identity (66.6% similar) in 410 aa overlap (13-410:45-443)
10 20 30 40
pF1KE0 MYRHGISSQRSWPLWTTIFIFLGVAA-ILGVTIGLLVHFLAV
:: .: .:. : ::...::: .::
NP_001 FRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCS
20 30 40 50 60 70
50 60 70 80 90
pF1KE0 EKTYYYQGDFH-ISGVTYND---NCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKS
: : ...:. : .. : .:... .. . .. .:..: .: .: . ..
NP_001 GK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC-VRVGGQNAVLQVFTAAS-WKTMCSD
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE0 EVIKLLPNANGSNVQLQLKFKFPPAEGVSMRTKIKAK---LHQMLKNNMASWNAVPASIK
. :. ... . . . :.. ... . . ..: .. .. :. :.
NP_001 DWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVT--ALHHSVY
140 150 160 170 180
160 170 180 190 200 210
pF1KE0 LMEISKAASEMLTNNC--CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGA
. : . :.....: .: ::.. . : ..::.:. :: . ::::::.:..: : ::.
NP_001 VRE-GCASGHVVTLQCTACGHRRGYS----SRIVGGNMSLLSQWPWQASLQFQGYHLCGG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 SLISSRWLLSAAHCFAKKNNSKDWTVNFGVV--VNKPYMTRKVQNIIFHENYSSPGLHDD
:.:. :...:::: :.::.. :.: ...: .. :..:..: .:. : .:
NP_001 SVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGND
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 IALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEAFLKII
:::..:: ..:.:.:. .:::... .. .. ..:::. .:. .:..: . .:
NP_001 IALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLI
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 DNKICNASYAYSGFVTDSMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDG
.::::: .:.:... ::::::...: .:.::.::::::. . : .:.::: .:.: :
NP_001 SNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIG
370 380 390 400 410 420
400 410
pF1KE0 CGKKNKPGVYTRVTSYRNWITSKTGL
:.. :::::::::::. .::
NP_001 CAEVNKPGVYTRVTSFLDWIHEQMERDLKT
430 440 450
>>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa)
initn: 455 init1: 221 opt: 727 Z-score: 919.8 bits: 179.3 E(85289): 1.7e-44
Smith-Waterman score: 727; 32.4% identity (66.2% similar) in 411 aa overlap (13-410:45-444)
10 20 30 40
pF1KE0 MYRHGISSQRSWPLWTTIFIFLGVAA-ILGVTIGLLVHFLAV
:: .: .:. : ::...::: .::
NP_076 FRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCS
20 30 40 50 60 70
50 60 70 80 90
pF1KE0 EKTYYYQGDFH-ISGVTYND---NCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKS
: : ...:. : .. : .:... .. . .. .:..: .: .: . ..
NP_076 GK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC-VRVGGQNAVLQVFTAAS-WKTMCSD
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE0 EVIKLLPNANGSNVQLQLKFKFPPAEGVSMRTKIKAK---LHQMLKNNMASWNAVPASIK
. :. ... . . . :.. ... . . ..: .. .. :. :.
NP_076 DWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVT--ALHHSVY
140 150 160 170 180
160 170 180 190 200 210
pF1KE0 LMEISKAASEMLTNNC--CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGA
. : . :.....: .: ::.. . : ..::.:. :: . ::::::.:..: : ::.
NP_076 VRE-GCASGHVVTLQCTACGHRRGYS----SRIVGGNMSLLSQWPWQASLQFQGYHLCGG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 SLISSRWLLSAAHCFAKKNNSKDWTVNFGVV--VNKPYMTRKVQNIIFHENYSSPGLHDD
:.:. :...:::: :.::.. :.: ...: .. :..:..: .:. : .:
NP_076 SVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGND
250 260 270 280 290 300
280 290 300 310 320
pF1KE0 IALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWG-TLYMNGSFPVILQEAFLKI
:::..:: ..:.:.:. .:::... .. .. ..::: : :. .:..: . .
NP_076 IALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE0 IDNKICNASYAYSGFVTDSMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGD
:.::::: .:.:... ::::::...: .:.::.::::::. . : .:.::: .:.:
NP_076 ISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGI
370 380 390 400 410 420
390 400 410
pF1KE0 GCGKKNKPGVYTRVTSYRNWITSKTGL
::.. :::::::::::. .::
NP_076 GCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
430 440 450
>>NP_115780 (OMIM: 605511) transmembrane protease serine (327 aa)
initn: 415 init1: 221 opt: 714 Z-score: 905.6 bits: 176.2 E(85289): 1e-43
Smith-Waterman score: 714; 41.2% identity (74.1% similar) in 255 aa overlap (161-410:68-317)
140 150 160 170 180
pF1KE0 IKAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNC--CGRQVANSIITGNKIVNG
:.....: .: ::.. . : ..::.:
NP_115 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS----SRIVGG
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE0 KSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGVV--VNK
. :: . ::::::.:..: : ::.:.:. :...:::: :.::.. :.: ...
NP_115 NMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDN
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE0 PYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSENDNVVV
: .. :..:..: .:. : .::::..:: ..:.:.:. .:::... .. .. .
NP_115 PAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE0 TGWG-TLYMNGSFPVILQEAFLKIIDNKICNASYAYSGFVTDSMLCAGFMSGEADACQND
.::: : :. .:..: . .:.::::: .:.:... ::::::...: .:.::.:
NP_115 SGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGD
220 230 240 250 260 270
370 380 390 400 410
pF1KE0 SGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKTGL
:::::. . : .:.::: .:.: ::.. :::::::::::. .::
NP_115 SGGPLVCQERR-LWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
280 290 300 310 320
416 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 21:38:51 2016 done: Thu Nov 3 21:38:52 2016
Total Scan time: 7.640 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]