Result of FASTA (omim) for
pF1KE0185
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0185, 256 aa
1>>>pF1KE0185 256 - 256 aa - 256 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3716+/-0.00038; mu= 11.7432+/- 0.024
mean_var=145.3750+/-29.959, 0's: 0 Z-trim(117.3): 96 B-trim: 0 in 0/51
Lambda= 0.106373
statistics sampled from 29071 (29184) to 29071 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.342), width: 16
Scan time: 6.690
The best scores are: opt bits E(85289)
NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 504 88.5 1.3e-17
NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 485 85.7 1.2e-16
NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 474 84.0 3.7e-16
XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 463 82.3 1.2e-15
NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 463 82.3 1.2e-15
XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 463 82.3 1.2e-15
XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 463 82.3 1.2e-15
XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 463 82.3 1.2e-15
NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 289 55.5 1.1e-07
>>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa)
initn: 462 init1: 363 opt: 504 Z-score: 437.3 bits: 88.5 E(85289): 1.3e-17
Smith-Waterman score: 504; 35.7% identity (71.4% similar) in 213 aa overlap (9-215:38-241)
10 20 30
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTF
.::.: .:.: .: ::.. ::.:::::::
NP_116 QIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTF
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 CKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFW
::.:::.... :. :: :. ..:::.:: :.:: ....:..::::::...: .: ::.
NP_116 CKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFY
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 KKNKPQENGQDDTSK--ADKPKVDEEG----DENEDDKDYHRSDPQIAICLDCLRNNGQS
: : : ... ...: ... : . ... :.: : :. .::. : ..:..
NP_116 -----QSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERL-SSGKD
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 GDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYM
.. : :..:..:::.:. : ... : .: : . ....: ..:.. ::. :..
NP_116 KNKSV--LQNKYVRCSVRAEVRHLRRVLCHRLML-NPQHVQLLFDNEVLPDHMTMKQIWL
190 200 210 220 230
220 230 240 250
pF1KE0 TRWRLRGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG
.::
NP_116 SRWFGKPSPLLLQYSVKEKRR
240 250
>>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa)
initn: 505 init1: 369 opt: 485 Z-score: 419.9 bits: 85.7 E(85289): 1.2e-16
Smith-Waterman score: 486; 37.1% identity (62.9% similar) in 240 aa overlap (9-247:125-344)
10 20 30
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTF
.....::: : ::::::: ::.:::::::
NP_001 EEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTF
100 110 120 130 140 150
40 50 60 70 80 90
pF1KE0 CKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFW
::.:::.:: :: ::.:. ::.:.:: .::: :..:..::: .:.:.: .. .:.
NP_001 CKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFY
160 170 180 190 200 210
100 110 120 130 140 150
pF1KE0 KKNKPQENGQDDTSKA-DKPKVDEEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVV
: : : . . : .: . .: .. .. : :.. . : ... : .
NP_001 K-----ERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHF
220 230 240 250 260
160 170 180 190 200 210
pF1KE0 KGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRL
: : :::.: : ..:.: ..::: :. : . ..:..:. :: .: :.: ..
NP_001 KPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICG------DHLLE-QYQTLREI
270 280 290 300 310 320
220 230 240 250
pF1KE0 RGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG
: : .. .: : :: : : .:.
NP_001 R----RAIGDAAMQ----DGLLVLHYGLVVSPLKIT
330 340 350
>>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa)
initn: 448 init1: 357 opt: 474 Z-score: 411.2 bits: 84.0 E(85289): 3.7e-16
Smith-Waterman score: 474; 33.7% identity (63.4% similar) in 246 aa overlap (9-237:9-242)
10 20 30 40 50 60
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
. ..::.. : .: ::.: ::. ::::.:::::::...: :. :: : ::
NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQV
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKV-
:.: :: .: :.::..:..:::::: ..:..:. .:. . :. .. . :. :. .:
NP_005 HKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAH-PSADAANG-SNEDRGEVA
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 DEEGDENEDDK---------DYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTR
::. ::. : .: : .. ... .: ..: :...:: .
NP_005 DEDKRIITDDEIISLSIEFFDQNRLDRKVN------KDKEKSKEEVND---KRYLRCPAA
120 130 140 150 160
180 190 200 210 220
pF1KE0 VTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDH--TMEFIYMTRWRLRGE---NFRCL
.:: ..::: :. .:.....::. . : . ::. :.. :. :: : ..:
NP_005 MTVMHLRKFLRSKMDIPNTFQIDVMYEEEPL-KDYYTLMDIAYIYTWRRNGPLPLKYRVR
170 180 190 200 210 220
230 240 250
pF1KE0 -NCSASQVCSQ-DGPLYQSYPMVLQYRPRIDFG
.:. .. : ::
NP_005 PTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPH
230 240 250 260 270 280
>>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 441 init1: 349 opt: 463 Z-score: 401.8 bits: 82.3 E(85289): 1.2e-15
Smith-Waterman score: 463; 36.4% identity (64.1% similar) in 217 aa overlap (9-219:9-221)
10 20 30 40 50 60
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
. ..::.. : .: ::.: ::..::::.:::::::...: .. :: : ::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQE--NGQDDTSKADKPK
:.: :: .: :.::..:..:::::: ..:..:. .:. : :: :. :. .
XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNG----SNEDRGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 V-DEEGDENEDDKDYHRSDPQIAICLDCLRNNG--QSGDNVVKGLMKKFIRCSTRVTVGT
: ..: ::. : : ...: ..::. . .:.:: . .::
XP_005 VLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 IKKFLSLKLKLPSSYELDVLCNGEIMGKDHT-MEFIYMTRWRLRGENFRCLNCSASQVCS
. ::: :. .::.:...:: . : . . .: :.. :. :: :
XP_005 LAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRL
180 190 200 210 220 230
240 250
pF1KE0 QDGPLYQSYPMVLQYRPRIDFG
XP_005 TLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATH
240 250 260 270 280 290
>>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa)
initn: 441 init1: 349 opt: 463 Z-score: 401.8 bits: 82.3 E(85289): 1.2e-15
Smith-Waterman score: 463; 36.4% identity (64.1% similar) in 217 aa overlap (9-219:9-221)
10 20 30 40 50 60
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
. ..::.. : .: ::.: ::..::::.:::::::...: .. :: : ::
NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQE--NGQDDTSKADKPK
:.: :: .: :.::..:..:::::: ..:..:. .:. : :: :. :. .
NP_009 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNG----SNEDRGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 V-DEEGDENEDDKDYHRSDPQIAICLDCLRNNG--QSGDNVVKGLMKKFIRCSTRVTVGT
: ..: ::. : : ...: ..::. . .:.:: . .::
NP_009 VLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 IKKFLSLKLKLPSSYELDVLCNGEIMGKDHT-MEFIYMTRWRLRGENFRCLNCSASQVCS
. ::: :. .::.:...:: . : . . .: :.. :. :: :
NP_009 LAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRL
180 190 200 210 220 230
240 250
pF1KE0 QDGPLYQSYPMVLQYRPRIDFG
NP_009 TLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATH
240 250 260 270 280 290
>>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 441 init1: 349 opt: 463 Z-score: 401.8 bits: 82.3 E(85289): 1.2e-15
Smith-Waterman score: 463; 36.4% identity (64.1% similar) in 217 aa overlap (9-219:9-221)
10 20 30 40 50 60
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
. ..::.. : .: ::.: ::..::::.:::::::...: .. :: : ::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQE--NGQDDTSKADKPK
:.: :: .: :.::..:..:::::: ..:..:. .:. : :: :. :. .
XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNG----SNEDRGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 V-DEEGDENEDDKDYHRSDPQIAICLDCLRNNG--QSGDNVVKGLMKKFIRCSTRVTVGT
: ..: ::. : : ...: ..::. . .:.:: . .::
XP_005 VLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 IKKFLSLKLKLPSSYELDVLCNGEIMGKDHT-MEFIYMTRWRLRGENFRCLNCSASQVCS
. ::: :. .::.:...:: . : . . .: :.. :. :: :
XP_005 LAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRL
180 190 200 210 220 230
240 250
pF1KE0 QDGPLYQSYPMVLQYRPRIDFG
XP_005 TLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATH
240 250 260 270 280 290
>>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 441 init1: 349 opt: 463 Z-score: 401.8 bits: 82.3 E(85289): 1.2e-15
Smith-Waterman score: 463; 36.4% identity (64.1% similar) in 217 aa overlap (9-219:9-221)
10 20 30 40 50 60
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
. ..::.. : .: ::.: ::..::::.:::::::...: .. :: : ::
XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQE--NGQDDTSKADKPK
:.: :: .: :.::..:..:::::: ..:..:. .:. : :: :. :. .
XP_016 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNG----SNEDRGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 V-DEEGDENEDDKDYHRSDPQIAICLDCLRNNG--QSGDNVVKGLMKKFIRCSTRVTVGT
: ..: ::. : : ...: ..::. . .:.:: . .::
XP_016 VLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 IKKFLSLKLKLPSSYELDVLCNGEIMGKDHT-MEFIYMTRWRLRGENFRCLNCSASQVCS
. ::: :. .::.:...:: . : . . .: :.. :. :: :
XP_016 LAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRL
180 190 200 210 220 230
240 250
pF1KE0 QDGPLYQSYPMVLQYRPRIDFG
XP_016 TLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATH
240 250 260 270 280 290
>>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 441 init1: 349 opt: 463 Z-score: 401.8 bits: 82.3 E(85289): 1.2e-15
Smith-Waterman score: 463; 36.4% identity (64.1% similar) in 217 aa overlap (9-219:9-221)
10 20 30 40 50 60
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
. ..::.. : .: ::.: ::..::::.:::::::...: .. :: : ::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQE--NGQDDTSKADKPK
:.: :: .: :.::..:..:::::: ..:..:. .:. : :: :. :. .
XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNG----SNEDRGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 V-DEEGDENEDDKDYHRSDPQIAICLDCLRNNG--QSGDNVVKGLMKKFIRCSTRVTVGT
: ..: ::. : : ...: ..::. . .:.:: . .::
XP_005 VLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 IKKFLSLKLKLPSSYELDVLCNGEIMGKDHT-MEFIYMTRWRLRGENFRCLNCSASQVCS
. ::: :. .::.:...:: . : . . .: :.. :. :: :
XP_005 LAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRL
180 190 200 210 220 230
240 250
pF1KE0 QDGPLYQSYPMVLQYRPRIDFG
XP_005 TLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATH
240 250 260 270 280 290
>>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa)
initn: 446 init1: 289 opt: 289 Z-score: 258.6 bits: 55.5 E(85289): 1.1e-07
Smith-Waterman score: 289; 63.8% identity (84.5% similar) in 58 aa overlap (9-66:125-182)
10 20 30
pF1KE0 MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTF
.....::: : ::::::: ::.:::::::
NP_115 EEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTF
100 110 120 130 140 150
40 50 60 70 80 90
pF1KE0 CKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFW
::.:::.:: :: ::.:. ::.:.::
NP_115 CKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVRVSGEATIGHVE
160 170 180 190 200 210
256 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 22:14:27 2016 done: Thu Nov 3 22:14:28 2016
Total Scan time: 6.690 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]