Result of FASTA (omim) for
pF1KB9784
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9784, 189 aa
1>>>pF1KB9784 189 - 189 aa - 189 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.3220+/-0.0003; mu= 7.8535+/- 0.019
mean_var=195.5258+/-38.658, 0's: 0 Z-trim(124.4): 61 B-trim: 2464 in 1/61
Lambda= 0.091722
statistics sampled from 46020 (46086) to 46020 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.829), E-opt: 0.2 (0.54), width: 16
Scan time: 6.890
The best scores are: opt bits E(85289)
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 1268 178.5 5.6e-45
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 266 46.0 5.4e-05
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 260 45.2 8.6e-05
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 260 45.2 8.6e-05
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 256 44.9 0.00017
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 239 42.4 0.00057
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 239 42.4 0.00057
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 226 40.5 0.0015
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 226 40.8 0.0023
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 223 40.3 0.0024
NP_620450 (OMIM: 606385) oligodendrocyte transcrip ( 271) 225 40.7 0.0025
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 219 39.8 0.004
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 220 40.1 0.0045
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 221 40.3 0.0045
NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193) 215 39.2 0.005
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217) 211 38.7 0.0078
XP_011513798 (OMIM: 101400,123100,180750,601622) P ( 202) 210 38.5 0.0081
NP_000465 (OMIM: 101400,123100,180750,601622) twis ( 202) 210 38.5 0.0081
>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli (189 aa)
initn: 1268 init1: 1268 opt: 1268 Z-score: 928.5 bits: 178.5 E(85289): 5.6e-45
Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 189 aa overlap (1-189:1-189)
10 20 30 40 50 60
pF1KB9 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_803 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 PGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_803 PGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_803 KNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYST
130 140 150 160 170 180
pF1KB9 QIHSFREGT
:::::::::
NP_803 QIHSFREGT
>>NP_542173 (OMIM: 609331) class E basic helix-loop-heli (241 aa)
initn: 206 init1: 112 opt: 266 Z-score: 210.7 bits: 46.0 E(85289): 5.4e-05
Smith-Waterman score: 266; 47.5% identity (68.3% similar) in 120 aa overlap (15-124:48-167)
10 20 30 40
pF1KB9 MKTKNRPPRRRAPVQDTEATPGEGTPD--GSLPN-PGPE-PAKG
.. ::. : ::: :.:: :.:. ::..
NP_542 AELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQA
20 30 40 50 60 70
50 60 70 80 90
pF1KB9 LRSRPARAAARAPG-EGRRRRPGP-SGPGGRRDSSIQR--RLESNERERQRMHKLNNAFQ
.: ... . . : :::: :: :. ::: :: :: : :::.::: ::.:..
NP_542 AESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALD
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB9 ALREVIPHVRAD--KKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQ
.:: :::.... .::::: :: ::::::
NP_542 GLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAAPVNAA
140 150 160 170 180 190
>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa)
initn: 247 init1: 194 opt: 260 Z-score: 207.0 bits: 45.2 E(85289): 8.6e-05
Smith-Waterman score: 260; 42.9% identity (65.4% similar) in 133 aa overlap (19-147:24-154)
10 20 30 40 50
pF1KB9 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAAR-APG
:. : : : : :.: ..: .. ... : ::
XP_016 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAP-PSPTRTRGNCAEAEEGGCRGAPR
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 EGRRRRPGPSGPGGRRDSSIQRRL---ESNERERQRMHKLNNAFQALREVIPHVRADKKL
. : :: : : : .. : ::: ..:.:::.:::.::.:..::: :.: : ::
XP_016 KLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 SKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQP
.::::: .:.::: .:: : : ... : .:: :.:
XP_016 TKIETLRFAHNYIWALTQT-LRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQ
120 130 140 150 160 170
180
pF1KB9 QGHLQRYSTQIHSFREGT
XP_016 AGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
180 190 200 210
>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa)
initn: 247 init1: 194 opt: 260 Z-score: 207.0 bits: 45.2 E(85289): 8.6e-05
Smith-Waterman score: 260; 42.9% identity (65.4% similar) in 133 aa overlap (19-147:24-154)
10 20 30 40 50
pF1KB9 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAAR-APG
:. : : : : :.: ..: .. ... : ::
NP_066 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAP-PSPTRTRGNCAEAEEGGCRGAPR
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 EGRRRRPGPSGPGGRRDSSIQRRL---ESNERERQRMHKLNNAFQALREVIPHVRADKKL
. : :: : : : .. : ::: ..:.:::.:::.::.:..::: :.: : ::
NP_066 KLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 SKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQP
.::::: .:.::: .:: : : ... : .:: :.:
NP_066 TKIETLRFAHNYIWALTQT-LRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQ
120 130 140 150 160 170
180
pF1KB9 QGHLQRYSTQIHSFREGT
NP_066 AGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
180 190 200 210
>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom (354 aa)
initn: 240 init1: 219 opt: 256 Z-score: 201.5 bits: 44.9 E(85289): 0.00017
Smith-Waterman score: 256; 37.6% identity (59.2% similar) in 157 aa overlap (29-177:115-265)
10 20 30 40 50
pF1KB9 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAK-GLRSRPARAAARAPGEGR
: .::: .. : . . ... : .:
NP_005 PELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSR
90 100 110 120 130 140
60 70 80 90 100 110
pF1KB9 RRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETL
.: :. . .: . :::: .: :::.::: ::.::. ::.::: :::::: :::
NP_005 QRAPSSKQVNGVQK---QRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETL
150 160 170 180 190 200
120 130 140 150 160 170
pF1KB9 TLAKNYIKSLTATILTMSSSRLPGLEGPGPKL----YQHYQQQQQVAGGALGATEA---Q
.:. ::..:. . : :... : : : ..: . . ::: .:: : :
NP_005 QMAQIYINALSELLQTPSGGEQP---PPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQ
210 220 230 240 250
180
pF1KB9 PQGHLQRYSTQIHSFREGT
.: ::
NP_005 ASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGS
260 270 280 290 300 310
>>NP_001073983 (OMIM: 609067) basic helix-loop-helix tra (201 aa)
initn: 224 init1: 224 opt: 239 Z-score: 192.3 bits: 42.4 E(85289): 0.00057
Smith-Waterman score: 241; 41.6% identity (61.6% similar) in 125 aa overlap (19-132:9-132)
10 20 30 40 50
pF1KB9 MKTKNRPPRRRAPVQDTEATPG-----EGTPDGSLPNPGPEPAKGLRSRPARA-AARAPG
: :: : .: . . : . ..: .: :. :::
NP_001 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSD-SSGSDEKPCRVHAARCGL
10 20 30 40
60 70 80 90 100
pF1KB9 EGRRRRPGP-----SGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADK
.: ::: : .::::: ..: .: :::.: ...:.:: ::: .:: ::.
NP_001 QGARRRAGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KB9 KLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEA
:::::::: ::..::. : ..:
NP_001 KLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARD
110 120 130 140 150 160
>>XP_006716679 (OMIM: 609067) PREDICTED: basic helix-loo (201 aa)
initn: 224 init1: 224 opt: 239 Z-score: 192.3 bits: 42.4 E(85289): 0.00057
Smith-Waterman score: 241; 41.6% identity (61.6% similar) in 125 aa overlap (19-132:9-132)
10 20 30 40 50
pF1KB9 MKTKNRPPRRRAPVQDTEATPG-----EGTPDGSLPNPGPEPAKGLRSRPARA-AARAPG
: :: : .: . . : . ..: .: :. :::
XP_006 MSFATLRPAPPGRYLYPEVSPLSEDEDRGSD-SSGSDEKPCRVHAARCGL
10 20 30 40
60 70 80 90 100
pF1KB9 EGRRRRPGP-----SGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADK
.: ::: : .::::: ..: .: :::.: ...:.:: ::: .:: ::.
XP_006 QGARRRAGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KB9 KLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEA
:::::::: ::..::. : ..:
XP_006 KLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARD
110 120 130 140 150 160
>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom (152 aa)
initn: 244 init1: 226 opt: 226 Z-score: 184.5 bits: 40.5 E(85289): 0.0015
Smith-Waterman score: 226; 47.6% identity (69.0% similar) in 84 aa overlap (45-128:10-93)
20 30 40 50 60 70
pF1KB9 QDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSI
:: : . : : . : . .:: .:.
NP_660 MKSCKPSGPPAGARVAPPCAGGTECAGTCAGAGRLESAA
10 20 30
80 90 100 110 120 130
pF1KB9 QRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTM
.::: .: :::.::. ::.::. ::.:.:. :::::: ::: .: .:: .::
NP_660 RRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMALTRILAEA
40 50 60 70 80 90
140 150 160 170 180
pF1KB9 SSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT
NP_660 ERFGSERDWVGLHCEHFGRDHYLPFPGAKLPGESELYSQRLFGFQPEPFQMAT
100 110 120 130 140 150
>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa)
initn: 232 init1: 208 opt: 226 Z-score: 181.5 bits: 40.8 E(85289): 0.0023
Smith-Waterman score: 236; 33.9% identity (55.0% similar) in 171 aa overlap (16-171:38-208)
10 20 30 40
pF1KB9 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRS--
: : :. :. . : : ..: :.
NP_076 LELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGV
10 20 30 40 50 60
50 60 70 80 90
pF1KB9 -------RPARAAARAPGEGRR-RRPGPSGPGGRRDSSIQR-----RLESNERERQRMHK
:::: . . :: : . :.. ..:: ::..:.:::.:::.
NP_076 AAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 LNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLY
:: :..:::::.: : ::.::::: .:.::: .:: :. . : :: .
NP_076 LNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFS
130 140 150 160 170 180
160 170 180
pF1KB9 QHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT
. . :..::... .:
NP_076 EAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSD
190 200 210 220 230 240
>>NP_004600 (OMIM: 601010) transcription factor 15 [Homo (199 aa)
initn: 231 init1: 178 opt: 223 Z-score: 180.9 bits: 40.3 E(85289): 0.0024
Smith-Waterman score: 230; 40.2% identity (60.6% similar) in 132 aa overlap (48-179:46-163)
20 30 40 50 60 70
pF1KB9 EATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSIQRR
:: :.:: : :: : .: .: ...:
NP_004 PDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPV-VVVRQR
20 30 40 50 60 70
80 90 100 110 120 130
pF1KB9 LESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSS
.: :::.: ...:.:: ::: .:: .:.:::::::: ::..:: : :..: ...:
NP_004 QAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHL-ANVLLLGDS
80 90 100 110 120 130
140 150 160 170 180
pF1KB9 RLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT
: : ..::.: ::. : .: : :
NP_004 ADDG------------QPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDL
140 150 160 170 180
NP_004 GGSCLKVRGVAPLRGPRR
190
189 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 18:54:26 2016 done: Fri Nov 4 18:54:27 2016
Total Scan time: 6.890 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]