Result of FASTA (omim) for
pF1KB9729
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9729, 446 aa
1>>>pF1KB9729 446 - 446 aa - 446 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.6135+/-0.000322; mu= 10.0157+/- 0.020
mean_var=195.0526+/-38.620, 0's: 0 Z-trim(122.3): 100 B-trim: 26 in 1/55
Lambda= 0.091833
statistics sampled from 40108 (40229) to 40108 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.472), width: 16
Scan time: 11.470
The best scores are: opt bits E(85289)
NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 3034 414.0 4e-115
XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 3021 412.3 1.3e-114
NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 876 128.2 5.2e-29
NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 876 128.2 5.2e-29
NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 876 128.2 5.2e-29
NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 626 95.0 4.7e-19
XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 626 95.0 4.9e-19
XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 552 85.2 4e-16
NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 552 85.2 4e-16
NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 552 85.2 4e-16
NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 518 80.8 1e-14
NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 518 80.8 1e-14
NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 503 78.7 3.7e-14
NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 503 78.7 3.7e-14
XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 494 77.5 8e-14
NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 494 77.5 8.4e-14
XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 461 73.1 1.6e-12
XP_016871597 (OMIM: 601332) PREDICTED: homeobox pr ( 291) 272 47.9 4.2e-05
XP_016871596 (OMIM: 601332) PREDICTED: homeobox pr ( 295) 272 47.9 4.3e-05
XP_016871594 (OMIM: 601332) PREDICTED: homeobox pr ( 352) 272 48.0 4.8e-05
NP_001229631 (OMIM: 601332) homeobox protein Mohaw ( 352) 272 48.0 4.8e-05
NP_775847 (OMIM: 601332) homeobox protein Mohawk [ ( 352) 272 48.0 4.8e-05
XP_016871595 (OMIM: 601332) PREDICTED: homeobox pr ( 352) 272 48.0 4.8e-05
>>NP_077311 (OMIM: 606196) iroquois-class homeodomain pr (446 aa)
initn: 3034 init1: 3034 opt: 3034 Z-score: 2187.8 bits: 414.0 E(85289): 4e-115
Smith-Waterman score: 3034; 100.0% identity (100.0% similar) in 446 aa overlap (1-446:1-446)
10 20 30 40 50 60
pF1KB9 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 RPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 RPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 PGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 MLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 MLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 EVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 EVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 EGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 EGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 SAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_077 SAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGL
370 380 390 400 410 420
430 440
pF1KB9 PLNCAPCPRRSEPVVQCQYPSGAEAG
::::::::::::::::::::::::::
NP_077 PLNCAPCPRRSEPVVQCQYPSGAEAG
430 440
>>XP_005256194 (OMIM: 606196) PREDICTED: iroquois-class (445 aa)
initn: 3021 init1: 3021 opt: 3021 Z-score: 2178.5 bits: 412.3 E(85289): 1.3e-114
Smith-Waterman score: 3021; 100.0% identity (100.0% similar) in 444 aa overlap (1-444:1-444)
10 20 30 40 50 60
pF1KB9 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 RPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 MLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 EVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 EGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 SAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGL
370 380 390 400 410 420
430 440
pF1KB9 PLNCAPCPRRSEPVVQCQYPSGAEAG
::::::::::::::::::::::::
XP_005 PLNCAPCPRRSEPVVQCQYPSGAEG
430 440
>>NP_001265561 (OMIM: 606199) iroquois-class homeodomain (519 aa)
initn: 820 init1: 452 opt: 876 Z-score: 641.8 bits: 128.2 E(85289): 5.2e-29
Smith-Waterman score: 973; 44.1% identity (66.4% similar) in 440 aa overlap (1-407:1-431)
10 20 30 40 50 60
pF1KB9 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
::.:.::.:: .: ::: ...: .::::: :...: . ... . : :.::::..:
NP_001 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110
pF1KB9 RPELG--AALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSL
: ::. ::::.::.::... :.: .:. :. : ..: .:: ... :...:: ..:
NP_001 RHELNSAAALGVYGGPYGGS---QGYGNYVTYGSEASAFY-SLN-SFDSKDGSGSAHGGL
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 AQPGA-YYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKG
: .: ::::: .:::: :.:::... ::. :::::::::::::::::.:::::::::::
NP_001 APAAAAYYPYEPALGQYPYDRYGTMD-SGT-RRKNATRETTSTLKAWLQEHRKNPYPTKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKA-------EGGEED
::::::::::::::::::::::::::::::::::: :.:: ..:.. :::::.
NP_001 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEE
180 190 200 210 220 230
240 250 260 270
pF1KB9 SLGCLTADTKEVT-ASQEARGLRLSDLEDLEEEEEEEEEAEDE----------EVVATAG
. ..:.. ...: . :.::::.:.. : : : . : : .:
NP_001 AREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAP
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB9 DRLTEFRKGA--QSLPGPCAAAREGRLER-RECGLAAPRFSFNDPSGSEEADFLSAETGS
: .. .:: .:: . .:: . ::: : : .: :.. . :. :
NP_001 DGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGF
300 310 320 330 340 350
340 350 360 370 380
pF1KB9 PRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPEC---RMIPGQP------PA
:::::::::::::.:. : . . . : : :. :. : ::
NP_001 VPAGASAGLEAKPRIWSLAHTATAAAA--AATSLSQTEFPSCMLKRQGPAAPAAVSSAPA
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB9 SARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
.. ...:...: :. . :
NP_001 TSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLG
420 430 440 450 460 470
>>NP_057442 (OMIM: 606199) iroquois-class homeodomain pr (519 aa)
initn: 820 init1: 452 opt: 876 Z-score: 641.8 bits: 128.2 E(85289): 5.2e-29
Smith-Waterman score: 973; 44.1% identity (66.4% similar) in 440 aa overlap (1-407:1-431)
10 20 30 40 50 60
pF1KB9 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
::.:.::.:: .: ::: ...: .::::: :...: . ... . : :.::::..:
NP_057 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110
pF1KB9 RPELG--AALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSL
: ::. ::::.::.::... :.: .:. :. : ..: .:: ... :...:: ..:
NP_057 RHELNSAAALGVYGGPYGGS---QGYGNYVTYGSEASAFY-SLN-SFDSKDGSGSAHGGL
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 AQPGA-YYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKG
: .: ::::: .:::: :.:::... ::. :::::::::::::::::.:::::::::::
NP_057 APAAAAYYPYEPALGQYPYDRYGTMD-SGT-RRKNATRETTSTLKAWLQEHRKNPYPTKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKA-------EGGEED
::::::::::::::::::::::::::::::::::: :.:: ..:.. :::::.
NP_057 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEE
180 190 200 210 220 230
240 250 260 270
pF1KB9 SLGCLTADTKEVT-ASQEARGLRLSDLEDLEEEEEEEEEAEDE----------EVVATAG
. ..:.. ...: . :.::::.:.. : : : . : : .:
NP_057 AREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAP
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB9 DRLTEFRKGA--QSLPGPCAAAREGRLER-RECGLAAPRFSFNDPSGSEEADFLSAETGS
: .. .:: .:: . .:: . ::: : : .: :.. . :. :
NP_057 DGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGF
300 310 320 330 340 350
340 350 360 370 380
pF1KB9 PRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPEC---RMIPGQP------PA
:::::::::::::.:. : . . . : : :. :. : ::
NP_057 VPAGASAGLEAKPRIWSLAHTATAAAA--AATSLSQTEFPSCMLKRQGPAAPAAVSSAPA
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB9 SARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
.. ...:...: :. . :
NP_057 TSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLG
420 430 440 450 460 470
>>NP_001265563 (OMIM: 606199) iroquois-class homeodomain (519 aa)
initn: 820 init1: 452 opt: 876 Z-score: 641.8 bits: 128.2 E(85289): 5.2e-29
Smith-Waterman score: 973; 44.1% identity (66.4% similar) in 440 aa overlap (1-407:1-431)
10 20 30 40 50 60
pF1KB9 MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSA
::.:.::.:: .: ::: ...: .::::: :...: . ... . : :.::::..:
NP_001 MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
10 20 30 40 50 60
70 80 90 100 110
pF1KB9 RPELG--AALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSL
: ::. ::::.::.::... :.: .:. :. : ..: .:: ... :...:: ..:
NP_001 RHELNSAAALGVYGGPYGGS---QGYGNYVTYGSEASAFY-SLN-SFDSKDGSGSAHGGL
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 AQPGA-YYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKG
: .: ::::: .:::: :.:::... ::. :::::::::::::::::.:::::::::::
NP_001 APAAAAYYPYEPALGQYPYDRYGTMD-SGT-RRKNATRETTSTLKAWLQEHRKNPYPTKG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKA-------EGGEED
::::::::::::::::::::::::::::::::::: :.:: ..:.. :::::.
NP_001 EKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEE
180 190 200 210 220 230
240 250 260 270
pF1KB9 SLGCLTADTKEVT-ASQEARGLRLSDLEDLEEEEEEEEEAEDE----------EVVATAG
. ..:.. ...: . :.::::.:.. : : : . : : .:
NP_001 AREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAP
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB9 DRLTEFRKGA--QSLPGPCAAAREGRLER-RECGLAAPRFSFNDPSGSEEADFLSAETGS
: .. .:: .:: . .:: . ::: : : .: :.. . :. :
NP_001 DGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGF
300 310 320 330 340 350
340 350 360 370 380
pF1KB9 PRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPEC---RMIPGQP------PA
:::::::::::::.:. : . . . : : :. :. : ::
NP_001 VPAGASAGLEAKPRIWSLAHTATAAAA--AATSLSQTEFPSCMLKRQGPAAPAAVSSAPA
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB9 SARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
.. ...:...: :. . :
NP_001 TSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLG
420 430 440 450 460 470
>>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa)
initn: 632 init1: 468 opt: 626 Z-score: 463.0 bits: 95.0 E(85289): 4.7e-19
Smith-Waterman score: 699; 40.9% identity (58.6% similar) in 418 aa overlap (57-429:36-421)
30 40 50 60 70
pF1KB9 CESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAA-------LGIYGAPYAAAA
::.. ::.:. ..:::::::::
NP_077 LGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAPYAAAA
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB9 AA---QSYPGYLPYSPEPPSLYGALNPQYEFKEAAG----SFTSSLAQPG-AYYPYERTL
:: :.: ..:::. : : .. :. :::.:.. : . .... .: :.:::
NP_077 AAAAAQGYGAFLPYAAELP-IFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY----
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB9 GQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLT
::::. . .: ::::::.::::::::::::::::::::::::::::::::::
NP_077 GQYQF--------GDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLT
130 140 150 160 170
200 210 220 230 240
pF1KB9 QVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGE----------EDSLGCLTADTKE
:::::::::::::::::::::::... :: .: :.: ::. : . .:
NP_077 QVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEE
180 190 200 210 220 230
250 260 270 280 290
pF1KB9 VTASQEARGLR--LSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAA
. . .: : . .: :: : . :. . : : .. :: . : : .: :: . .
NP_077 LGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAG---AARRDGDLGL-GPISDS
240 250 260 270 280
300 310 320 330 340
pF1KB9 REGRLERRECGLAA---PRFSFNDPSGSEEADFLSAETGSPRLTMHYPC---------LE
... : :: : .:. :. : : :: ... :: :.
NP_077 KNSDSEDSSEGLEDRPLPVLSLA-PAPPPVA-VASPSLPSPPVSLD-PCAPAPAPASALQ
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 KPRIWSLAHTATASAVEGAPPARPRPRSPECRMIPGQPPA-----SARRLSVPRDSACDE
::.:::::.:::. : :: ::: :.::. :: .:: : .:
NP_077 KPKIWSLAETATS-------PDNPR-RSPP--GAGGSPPGAAVAPSALQLS-PAAAAAAA
350 360 370 380 390
410 420 430 440
pF1KB9 SSCIPKAFGN-PKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
. .:. : .. . .: . : ::
NP_077 HRLVSAPLGKFPAWTNRPFP-GPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFAR
400 410 420 430 440 450
>>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa)
initn: 632 init1: 468 opt: 626 Z-score: 462.7 bits: 95.0 E(85289): 4.9e-19
Smith-Waterman score: 699; 40.9% identity (58.6% similar) in 418 aa overlap (57-429:36-421)
30 40 50 60 70
pF1KB9 CESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAA-------LGIYGAPYAAAA
::.. ::.:. ..:::::::::
XP_005 LGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAPYAAAA
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB9 AA---QSYPGYLPYSPEPPSLYGALNPQYEFKEAAG----SFTSSLAQPG-AYYPYERTL
:: :.: ..:::. : : .. :. :::.:.. : . .... .: :.:::
XP_005 AAAAAQGYGAFLPYAAELP-IFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPY----
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB9 GQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLT
::::. . .: ::::::.::::::::::::::::::::::::::::::::::
XP_005 GQYQF--------GDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLT
130 140 150 160 170
200 210 220 230 240
pF1KB9 QVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGE----------EDSLGCLTADTKE
:::::::::::::::::::::::... :: .: :.: ::. : . .:
XP_005 QVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEE
180 190 200 210 220 230
250 260 270 280 290
pF1KB9 VTASQEARGLR--LSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAA
. . .: : . .: :: : . :. . : : .. :: . : : .: :: . .
XP_005 LGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAG---AARRDGDLGL-GPISDS
240 250 260 270 280
300 310 320 330 340
pF1KB9 REGRLERRECGLAA---PRFSFNDPSGSEEADFLSAETGSPRLTMHYPC---------LE
... : :: : .:. :. : : :: ... :: :.
XP_005 KNSDSEDSSEGLEDRPLPVLSLA-PAPPPVA-VASPSLPSPPVSLD-PCAPAPAPASALQ
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 KPRIWSLAHTATASAVEGAPPARPRPRSPECRMIPGQPPA-----SARRLSVPRDSACDE
::.:::::.:::. : :: ::: :.::. :: .:: : .:
XP_005 KPKIWSLAETATS-------PDNPR-RSPP--GAGGSPPGAAVAPSALQLS-PAAAAAAA
350 360 370 380 390
410 420 430 440
pF1KB9 SSCIPKAFGN-PKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
. .:. : .. . .: . : ::
XP_005 HRLVSAPLGKFPAWTNRPFP-GPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFAR
400 410 420 430 440 450
>>XP_011512281 (OMIM: 606198) PREDICTED: iroquois-class (471 aa)
initn: 574 init1: 451 opt: 552 Z-score: 410.4 bits: 85.2 E(85289): 4e-16
Smith-Waterman score: 598; 36.6% identity (55.7% similar) in 404 aa overlap (49-422:20-407)
20 30 40 50 60 70
pF1KB9 SASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAALGIYGAPYAAA
: : . :.. : : : :..
XP_011 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSE-------ELARSASG
10 20 30 40
80 90 100 110 120 130
pF1KB9 AAAQSYPGYLPYSPEPPSLYGA-LNPQYEFKEAAGSFTSSLAQPGAYYPYERTLGQYQYE
.: . ::: .. . . .:. :. . . ::..: : .. : . : : .:.
XP_011 SAFSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMT-GAISYH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB9 RYGAV----ELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
::.. .:. . ::::::..:.::::::::::::::::::::::::::::::::::
XP_011 PYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB9 STWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVT-ASQEARGLR
:::::::::::::::::::::.::. .: . :: : ..: : .: : .:.
XP_011 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
170 180 190 200 210 220
260 270 280 290 300
pF1KB9 LSDLEDLEEEEEEEEEAEDEEVVATAGDRL----TEFRKGAQSLPGPCAAAREGRLERRE
: : .. :.. :.. ::: : .: . ..: .:: ::
XP_011 LH--VDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEG--ER--
230 240 250 260 270
310 320 330 340 350
pF1KB9 CGLAAPRFSFNDPSGSEEADFLS-----AETG---SPRLTMHYPCLE----KPRIWSLAH
::: :. ..: . :: .:: : : .:. . : ::..::::.
XP_011 -GLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAE
280 290 300 310 320 330
360 370 380 390 400
pF1KB9 TATASAVEGA------PPARPRPRSPECRMIP--GQPPASARRLSVPRDSACDESSCIPK
::.. . . ::. : .: : :.: .. :. : . . .
XP_011 IATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTN
340 350 360 370 380 390
410 420 430 440
pF1KB9 AFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
.:: . :::: :
XP_011 -YGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRSPGGGYEPK
400 410 420 430 440 450
>>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa)
initn: 574 init1: 451 opt: 552 Z-score: 410.4 bits: 85.2 E(85289): 4e-16
Smith-Waterman score: 598; 36.6% identity (55.7% similar) in 404 aa overlap (49-422:20-407)
20 30 40 50 60 70
pF1KB9 SASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAALGIYGAPYAAA
: : . :.. : : : :..
NP_150 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSE-------ELARSASG
10 20 30 40
80 90 100 110 120 130
pF1KB9 AAAQSYPGYLPYSPEPPSLYGA-LNPQYEFKEAAGSFTSSLAQPGAYYPYERTLGQYQYE
.: . ::: .. . . .:. :. . . ::..: : .. : . : : .:.
NP_150 SAFSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMT-GAISYH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB9 RYGAV----ELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
::.. .:. . ::::::..:.::::::::::::::::::::::::::::::::::
NP_150 PYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB9 STWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVT-ASQEARGLR
:::::::::::::::::::::.::. .: . :: : ..: : .: : .:.
NP_150 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
170 180 190 200 210 220
260 270 280 290 300
pF1KB9 LSDLEDLEEEEEEEEEAEDEEVVATAGDRL----TEFRKGAQSLPGPCAAAREGRLERRE
: : .. :.. :.. ::: : .: . ..: .:: ::
NP_150 LH--VDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEG--ER--
230 240 250 260 270
310 320 330 340 350
pF1KB9 CGLAAPRFSFNDPSGSEEADFLS-----AETG---SPRLTMHYPCLE----KPRIWSLAH
::: :. ..: . :: .:: : : .:. . : ::..::::.
NP_150 -GLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAE
280 290 300 310 320 330
360 370 380 390 400
pF1KB9 TATASAVEGA------PPARPRPRSPECRMIP--GQPPASARRLSVPRDSACDESSCIPK
::.. . . ::. : .: : :.: .. :. : . . .
NP_150 IATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTN
340 350 360 370 380 390
410 420 430 440
pF1KB9 AFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
.:: . :::: :
NP_150 -YGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRSPGGGYEPK
400 410 420 430 440 450
>>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa)
initn: 574 init1: 451 opt: 552 Z-score: 410.4 bits: 85.2 E(85289): 4e-16
Smith-Waterman score: 598; 36.6% identity (55.7% similar) in 404 aa overlap (49-422:20-407)
20 30 40 50 60 70
pF1KB9 SASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAALGIYGAPYAAA
: : . :.. : : : :..
NP_001 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSE-------ELARSASG
10 20 30 40
80 90 100 110 120 130
pF1KB9 AAAQSYPGYLPYSPEPPSLYGA-LNPQYEFKEAAGSFTSSLAQPGAYYPYERTLGQYQYE
.: . ::: .. . . .:. :. . . ::..: : .. : . : : .:.
NP_001 SAFSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMT-GAISYH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB9 RYGAV----ELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
::.. .:. . ::::::..:.::::::::::::::::::::::::::::::::::
NP_001 PYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB9 STWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVT-ASQEARGLR
:::::::::::::::::::::.::. .: . :: : ..: : .: : .:.
NP_001 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
170 180 190 200 210 220
260 270 280 290 300
pF1KB9 LSDLEDLEEEEEEEEEAEDEEVVATAGDRL----TEFRKGAQSLPGPCAAAREGRLERRE
: : .. :.. :.. ::: : .: . ..: .:: ::
NP_001 LH--VDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEG--ER--
230 240 250 260 270
310 320 330 340 350
pF1KB9 CGLAAPRFSFNDPSGSEEADFLS-----AETG---SPRLTMHYPCLE----KPRIWSLAH
::: :. ..: . :: .:: : : .:. . : ::..::::.
NP_001 -GLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAE
280 290 300 310 320 330
360 370 380 390 400
pF1KB9 TATASAVEGA------PPARPRPRSPECRMIP--GQPPASARRLSVPRDSACDESSCIPK
::.. . . ::. : .: : :.: .. :. : . . .
NP_001 IATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTN
340 350 360 370 380 390
410 420 430 440
pF1KB9 AFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
.:: . :::: :
NP_001 -YGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRSPGGGYEPK
400 410 420 430 440 450
446 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:59:29 2016 done: Fri Nov 4 21:59:31 2016
Total Scan time: 11.470 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]