Result of FASTA (omim) for
pF1KB9635
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9635, 323 aa
1>>>pF1KB9635 323 - 323 aa - 323 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9249+/-0.000314; mu= 2.0756+/- 0.020
mean_var=255.3907+/-52.108, 0's: 0 Z-trim(124.5): 30 B-trim: 429 in 1/58
Lambda= 0.080255
statistics sampled from 46390 (46426) to 46390 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.544), width: 16
Scan time: 7.470
The best scores are: opt bits E(85289)
XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323) 2159 262.1 1.1e-69
NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323) 2159 262.1 1.1e-69
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 613 83.1 7.4e-16
NP_689627 (OMIM: 613483) class E basic helix-loop- ( 381) 455 64.9 3e-10
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 347 52.2 1.3e-06
NP_620450 (OMIM: 606385) oligodendrocyte transcrip ( 271) 317 48.8 1.5e-05
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 275 44.1 0.00057
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 244 40.3 0.0048
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 238 39.7 0.0099
>>XP_005260965 (OMIM: 606386) PREDICTED: oligodendrocyte (323 aa)
initn: 2159 init1: 2159 opt: 2159 Z-score: 1372.2 bits: 262.1 E(85289): 1.1e-69
Smith-Waterman score: 2159; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
250 260 270 280 290 300
310 320
pF1KB9 PPPHHHVSAMGAGSLPRLTSDAK
:::::::::::::::::::::::
XP_005 PPPHHHVSAMGAGSLPRLTSDAK
310 320
>>NP_005797 (OMIM: 606386) oligodendrocyte transcription (323 aa)
initn: 2159 init1: 2159 opt: 2159 Z-score: 1372.2 bits: 262.1 E(85289): 1.1e-69
Smith-Waterman score: 2159; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
250 260 270 280 290 300
310 320
pF1KB9 PPPHHHVSAMGAGSLPRLTSDAK
:::::::::::::::::::::::
NP_005 PPPHHHVSAMGAGSLPRLTSDAK
310 320
>>NP_786923 (OMIM: 609323) oligodendrocyte transcription (272 aa)
initn: 924 init1: 554 opt: 613 Z-score: 405.7 bits: 83.1 E(85289): 7.4e-16
Smith-Waterman score: 912; 50.2% identity (70.9% similar) in 323 aa overlap (1-323:1-268)
10 20 30 40 50 60
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
:.::.: :::: :::. :...: . . . . ::: .: ..
NP_786 MNSDSSSVSSRASSPDMDEMYLRDHHHRHHHHQESRLNSVSSTQGDMMQKM---------
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR
::..:. .: :. :. :: : :::..: .:::::::::.:::::
NP_786 -----PGESLSRAGAKA-----------AGESSKYKIKKQLSEQDLQQLRLKINGRERKR
60 70 80 90
130 140 150 160 170 180
pF1KB9 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH
:::::.:::::::::::::::::::::::::::::::::::::.:::::::::.::::::
NP_786 MHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGGH
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB9 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS
:..:: :: ..::: .::: ::...: :. :::: ..: ... :.. .:.
NP_786 HSAFH---CGTVGHSA------GHPAHAANSVH-PV--HPIL---GGALSSGNASSPLSA
160 170 180 190 200
250 260 270 280 290 300
pF1KB9 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV
:: ::..:.:::::.:::.::. : :: .:::::.:.::::..::.
NP_786 AS-----LPAIGTIRPPHSLLKAPSTPPALQLG---------SGFQHWAGLPCPCTICQM
210 220 230 240
310 320
pF1KB9 PPPHHHVSAMGAGSLPRLTSDAK
::: : .::...... ::....:
NP_786 PPPPH-LSALSTANMARLSAESKDLLK
250 260 270
>>NP_689627 (OMIM: 613483) class E basic helix-loop-heli (381 aa)
initn: 598 init1: 367 opt: 455 Z-score: 305.0 bits: 64.9 E(85289): 3e-10
Smith-Waterman score: 458; 44.2% identity (68.8% similar) in 224 aa overlap (23-241:167-372)
10 20 30 40 50
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELS
: : :..: ::. .. :. . .
NP_689 SVAESSGGEQSPDDDSDGRCELVLRAGVADPRASPGAGG----GGAKAAEGCSNAHLHGG
140 150 160 170 180 190
60 70 80 90 100 110
pF1KB9 AELR-GAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRL
: . :..:..:. :.. :.:: ..:.: :...::...::.::.:.: . :::
NP_689 ASVPPGGLGGGGGG-GSSSGSSGGGGGSGSGSGGSSSSSSSSSKKSKEQ------KALRL
200 210 220 230 240
120 130 140 150 160 170
pF1KB9 KINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKR
.::.:::.:::::: :.: :: :.::::.:::::::::::::::.::::: ...::::.:
NP_689 NINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRR
250 260 270 280 290 300
180 190 200 210 220
pF1KB9 LVSEIYGGH--HAGFHPSACGGLAHSAPLPAATAHPAAAAH--AAHHPAVHHPILPPAAA
::. . :. :. ::. .. : .: : ::: .:. :: .: :::::.
NP_689 LVAYLNQGQAISAASLPSSAAAAAAAAAL-----HPALGAYEQAAGYP--FSAGLPPAAS
310 320 330 340 350
230 240 250 260 270 280
pF1KB9 AAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQH
: .:::.
NP_689 CPEKCALFNSVSSSLCKQCTEKP
360 370 380
>>NP_542173 (OMIM: 609331) class E basic helix-loop-heli (241 aa)
initn: 394 init1: 336 opt: 347 Z-score: 239.9 bits: 52.2 E(85289): 1.3e-06
Smith-Waterman score: 364; 41.5% identity (67.0% similar) in 188 aa overlap (24-211:53-215)
10 20 30 40 50
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSA
::. :. : :: . .. :. : .:
NP_542 LSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPG---PGGDLPAA-PAPRAPAQAA
30 40 50 60 70
60 70 80 90 100 110
pF1KB9 ELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKI
: :.: . ::. ..:.. . .. ::.. .. ..: ..:::.:
NP_542 E------SSGEQSGDE--DDAFEQRRRRRGPGS---AADGRRRPREQ------RSLRLSI
80 90 100 110 120
120 130 140 150 160 170
pF1KB9 NSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLV
:.:::.:::::: :.:::: :.::::.:::::::::::::::.::::: ...:.::.:::
NP_542 NARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 SEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAA
. . :. :. .: . : .:. ::. : .:. :
NP_542 AFLNQGQ--GL--AAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHC
190 200 210 220 230
240 250 260 270 280 290
pF1KB9 AAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPC
NP_542 HEKP
240
>>NP_620450 (OMIM: 606385) oligodendrocyte transcription (271 aa)
initn: 387 init1: 159 opt: 317 Z-score: 220.5 bits: 48.8 E(85289): 1.5e-05
Smith-Waterman score: 358; 36.5% identity (50.7% similar) in 304 aa overlap (11-301:19-253)
10 20 30 40
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPA--------RSKGSSGSAFTGGTVSSSTP
::. .: :: : : :. ::.:. :..: :.:.
NP_620 MYYAVSQARVNAVPGTMLRPQ--RPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSS
10 20 30 40 50
50 60 70 80 90 100
pF1KB9 SDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEP
: : : : : :.: ::: . ..:.. : : :
NP_620 STTAPLLPKAAR-EKPEAPAEPPGPGPGSG-------------AHPGGSARPDAK---EE
60 70 80 90 100
110 120 130 140 150
pF1KB9 ELQQLRLKINSRERKRMHDLNIAMDGLREV-MPY--AH--GPSVRKLSKIATLLLARNYI
. :::: ::::::::::.:::.:::.:::: .:: :: : ::::::::::::::::
NP_620 QQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYI
110 120 130 140 150 160
160 170 180 190 200 210
pF1KB9 LMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHH
:.: .::.:..: ..: : :.: : : :: .: :...
NP_620 LLLGSSLQELRRALGE-------GAGPAAPRLLL--AGLPLLAAAPGSV-----------
170 180 190 200
220 230 240 250 260 270
pF1KB9 PILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGS
.: :.:.. : : : .: .:: : . : :::.::
NP_620 -LLAPGAVGPPDALRPAKYLSLALD----------EPPCGQFALP--------GGGAGGP
210 220 230 240
280 290 300 310 320
pF1KB9 GASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK
: : :..:. :
NP_620 GL-----------CTCAVCKFPHLVPASLGLAAVQAQFSK
250 260 270
>>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa)
initn: 246 init1: 126 opt: 275 Z-score: 192.3 bits: 44.1 E(85289): 0.00057
Smith-Waterman score: 275; 31.4% identity (52.3% similar) in 287 aa overlap (55-316:60-333)
30 40 50 60 70 80
pF1KB9 RSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGG--SGFKSSSSST
::: :. .. : : .: .
NP_006 RSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKEEGELGGEEEEEEEE
30 40 50 60 70 80
90 100 110 120 130
pF1KB9 SSSTSSAAASSTKK---DKKQMTEPELQQLRL---KINSRERKRMHDLNIAMDGLREVMP
. . : . :: :..::. .:.. .: : :.:::.:::::: :.:.::.:.:
NP_006 EEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVP
90 100 110 120 130 140
140 150 160 170 180
pF1KB9 -YAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKR--LVSEIYGGHHAGFHPSA-----
:.. ..::::: :: ::.::: :.. :. :: ::: . .. .:..
NP_006 CYSK---TQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAG
150 160 170 180 190 200
190 200 210 220 230 240
pF1KB9 CGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGL
: : : : :. :.. : . :: : . :.: ::. : :
NP_006 CLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAG-------GLGG
210 220 230 240 250
250 260 270 280 290 300
pF1KB9 PSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCP-C-----SMCQVPP
.. ..: :: . . :: .::::.: .. .. : . : : :. :
NP_006 GAAHALRT-HGYCAAYETLYAA--AGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSS
260 270 280 290 300 310
310 320
pF1KB9 PHHHVS---AMGAGSLPRLTSDAK
: :. : .: ..::
NP_006 PDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEEL
320 330 340 350 360 370
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 230 init1: 122 opt: 244 Z-score: 175.6 bits: 40.3 E(85289): 0.0048
Smith-Waterman score: 244; 30.4% identity (54.4% similar) in 237 aa overlap (29-258:17-237)
10 20 30 40 50 60
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG
:::: ..: . :: :.:. : .
NP_006 MPARLETCISDLDCASSSGSDLSGFL---TDEEDC-----ARLQQA-A
10 20 30
70 80 90 100 110
pF1KB9 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQM-TEPELQQLR----LKINS
::.. :. :. : .: . .. .. .. . .. .: :..:: .: :.
NP_006 SASGPPAPARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKAND
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB9 RERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSE
:::.:::.:: :.:.:: :.: :. ::.:: :: .: ::: :...: ::...
NP_006 RERNRMHNLNAALDALRSVLP--SFPDDTKLTKIETLRFAYNYIWALAETL----RLADQ
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB9 IY--GGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAA
:: . . : : . : ::. :. ... :: : . : : :. .
NP_006 GLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGAAAASP-LSDPSSPAASEDFTYRP
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB9 AAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPC
. . : ::: . : .. . : :
NP_006 GDPVFSFPSLPKDLLHTTPCFIPYH
220 230
>>NP_835455 (OMIM: 607194,609069,615935) pancreas transc (328 aa)
initn: 237 init1: 142 opt: 238 Z-score: 170.0 bits: 39.7 E(85289): 0.0099
Smith-Waterman score: 239; 30.4% identity (53.0% similar) in 230 aa overlap (4-226:64-277)
10 20 30
pF1KB9 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSA
:.. . .:. : : : :.:. :
NP_835 DPLEDGDELLADEQAEVEFLSHQLHEYCYRDGACLLLQPAPPAAP-LALAPPSSGGLGEP
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB9 FTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASS
:: . . :: :. : :.: .:.. : .. . :.:::..
NP_835 DDGGGGGYCCETGAPPGGFPYSPGSPPSCLAYP---CAGAAVLSPGARLRG-LSGAAAAA
100 110 120 130 140
100 110 120 130 140 150
pF1KB9 TKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLL
... .. .: :::::: : :::.::...: :..::: .: : ..:::. ::
NP_835 ARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTL--PYEKRLSKVDTLR
150 160 170 180 190 200
160 170 180 190 200
pF1KB9 LARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPL----PAATAHPAAAA
:: .:: : : :. . . :: .: ::: . .. : :.. :. .
NP_835 LAIGYI----NFLSELVQADLPLRGGGAGG-----CGGPGGGGRLGGDSPGSQAQKVIIC
210 220 230 240 250
210 220 230 240 250 260
pF1KB9 H-AAHHPAVHHPI--LPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSA
: ... :. : ::: :
NP_835 HRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSSFNN
260 270 280 290 300 310
323 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:04:32 2016 done: Tue Nov 8 01:04:33 2016
Total Scan time: 7.470 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]