FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9631, 272 aa
1>>>pF1KB9631 272 - 272 aa - 272 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.6985+/-0.00026; mu= 6.7252+/- 0.016
mean_var=173.2169+/-34.990, 0's: 0 Z-trim(124.9): 61 B-trim: 0 in 0/58
Lambda= 0.097449
statistics sampled from 47357 (47421) to 47357 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.836), E-opt: 0.2 (0.556), width: 16
Scan time: 9.260
The best scores are: opt bits E(85289)
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 1811 265.4 7.8e-71
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 437 72.2 9.9e-13
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 414 69.0 8.6e-12
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 414 69.0 8.6e-12
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 297 52.7 1.1e-06
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 295 52.4 1.5e-06
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 268 48.6 1.8e-05
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 267 48.4 2e-05
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 262 47.8 3.4e-05
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 236 44.1 0.00041
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 226 42.5 0.00071
NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323) 228 43.0 0.00088
XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323) 228 43.0 0.00088
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 224 42.3 0.0011
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 219 41.5 0.0015
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 219 41.5 0.0015
NP_689627 (OMIM: 613483) class E basic helix-loop- ( 381) 211 40.6 0.0052
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 203 39.2 0.0057
NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193) 204 39.4 0.0062
>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa)
initn: 1811 init1: 1811 opt: 1811 Z-score: 1392.7 bits: 265.4 E(85289): 7.8e-71
Smith-Waterman score: 1811; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272)
10 20 30 40 50 60
pF1KB9 MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 QGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 QGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 ERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 ERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 LPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 LPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSP
190 200 210 220 230 240
250 260 270
pF1KB9 ASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI
::::::::::::::::::::::::::::::::
NP_076 ASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI
250 260 270
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 476 init1: 373 opt: 437 Z-score: 349.5 bits: 72.2 E(85289): 9.9e-13
Smith-Waterman score: 437; 46.2% identity (67.7% similar) in 186 aa overlap (51-233:33-215)
30 40 50 60 70
pF1KB9 GSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEG-CRPARL
:: :..: :. : . . :: . : ...
NP_006 ARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASAS-GPPAPARRGAPNISRASEV
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB9 LGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVL
: : ..: : :. .: ... .. ....::.:::.::::::::::::::::: ::
NP_006 PGAQDDEQER-RRRRGRTR-VRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVL
70 80 90 100 110
140 150 160 170 180 190
pF1KB9 PTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASA
:.::.:.:::::::::::.::::::.:::::::. :::. : . : :: :
NP_006 PSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSP
120 130 140 150 160 170
200 210 220 230 240 250
pF1KB9 ALS--SSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPD
: . : :.. . :: : .::: : . . .:
NP_006 ASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
180 190 200 210 220 230
260 270
pF1KB9 KHRYAPHLPIARDCI
>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa)
initn: 423 init1: 372 opt: 414 Z-score: 332.6 bits: 69.0 E(85289): 8.6e-12
Smith-Waterman score: 427; 48.4% identity (64.7% similar) in 190 aa overlap (64-247:43-212)
40 50 60 70 80 90
pF1KB9 SSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEG-CR--PARLLGLVHDCKRRP
::. : . :: :: : .: . ::
NP_066 VTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRA------RRG
20 30 40 50 60
100 110 120 130 140 150
pF1KB9 SRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTK
.:.: :. .... ...:: :::.::::::::::.:::::: ::::::.::::::
NP_066 GRSRP-----KSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK
70 80 90 100 110 120
160 170 180 190 200 210
pF1KB9 IETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSP
:::::::::::::::.:::.::: . :. .: : :::: : :: :
NP_066 IETLRFAHNYIWALTQTLRIADHSLYALEP-PAPHCGE--LGSPGG------SPGDWGSL
130 140 150 160 170
220 230 240 250 260
pF1KB9 ASTWSCTNSPAPSSSVSSNST---SPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPI
: : ..: .:..:. . .: :::.: : ::
NP_066 YSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
180 190 200 210
270
pF1KB9 ARDCI
>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa)
initn: 423 init1: 372 opt: 414 Z-score: 332.6 bits: 69.0 E(85289): 8.6e-12
Smith-Waterman score: 427; 48.4% identity (64.7% similar) in 190 aa overlap (64-247:43-212)
40 50 60 70 80 90
pF1KB9 SSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEG-CR--PARLLGLVHDCKRRP
::. : . :: :: : .: . ::
XP_016 VTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRA------RRG
20 30 40 50 60
100 110 120 130 140 150
pF1KB9 SRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTK
.:.: :. .... ...:: :::.::::::::::.:::::: ::::::.::::::
XP_016 GRSRP-----KSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK
70 80 90 100 110 120
160 170 180 190 200 210
pF1KB9 IETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSP
:::::::::::::::.:::.::: . :. .: : :::: : :: :
XP_016 IETLRFAHNYIWALTQTLRIADHSLYALEP-PAPHCGE--LGSPGG------SPGDWGSL
130 140 150 160 170
220 230 240 250 260
pF1KB9 ASTWSCTNSPAPSSSVSSNST---SPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPI
: : ..: .:..:. . .: :::.: : ::
XP_016 YSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
180 190 200 210
270
pF1KB9 ARDCI
>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff (356 aa)
initn: 326 init1: 271 opt: 297 Z-score: 240.8 bits: 52.7 E(85289): 1.1e-06
Smith-Waterman score: 297; 38.0% identity (57.8% similar) in 192 aa overlap (85-265:76-253)
60 70 80 90 100 110
pF1KB9 RGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRR
: ..:.: :. .. : ..:.: ::
NP_002 MNAEEDSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKR-RGPKKKKMTKARLERFK-LRR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB9 LKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHC
.::: :::::::.:::::: ::.:.: . . ::.::::::.:.::::::.: ::
NP_002 MKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILR-----
110 120 130 140 150
180 190 200 210 220
pF1KB9 GGGGGGLPGALFSEAVLLSPGGA--SAALSSSGDSPSPASTWSCTNSPAPS---SSVSSN
.: : : : . : : . .. : .. . .: . :. : .. .:
NP_002 ---SGKSPD-LVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASF
160 170 180 190 200 210
230 240 250 260 270
pF1KB9 STSPYSCTLSPA--SPAGSDMD----YWQPPPPDKHRYAPHLPIARDCI
. ::: ::. :: . :: . ::: : :. :
NP_002 PVHPYS-YQSPGLPSPPYGTMDSSHVFHVKPPP--HAYSAALEPFFESPLTDCTSPSFDG
220 230 240 250 260 270
NP_002 PLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGAQSHGSIFSGTAAPRCEIPID
280 290 300 310 320 330
>>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa)
initn: 351 init1: 268 opt: 295 Z-score: 238.8 bits: 52.4 E(85289): 1.5e-06
Smith-Waterman score: 295; 44.4% identity (64.4% similar) in 135 aa overlap (45-169:46-178)
20 30 40 50 60
pF1KB9 DVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQ-----RGAEAGQGARG----
::: : :: :: :. ... .
NP_006 PKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAEVKE
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB9 -GVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNR
: .: : . . :: . .::.. :. .. : ..: .: :: ::: :::::
NP_006 EGELGGEEEEEEEEEEGLDEAEGERPKK-RGPKKRKMTKARLER-SKLRRQKANARERNR
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB9 MHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGA
::.:::::: ::.:.: . . ::.::::::.:.::::::.: ::
NP_006 MHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLC
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB9 LFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPA
NP_006 KGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQA
200 210 220 230 240 250
>>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa)
initn: 302 init1: 255 opt: 268 Z-score: 219.1 bits: 48.6 E(85289): 1.8e-05
Smith-Waterman score: 290; 34.6% identity (57.1% similar) in 191 aa overlap (92-256:75-264)
70 80 90 100 110 120
pF1KB9 GARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRE
: :.. . : ..:.: :: .:: ::
NP_073 GKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVK-FRRQEANARE
50 60 70 80 90 100
130 140 150 160 170
pF1KB9 RNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADH--------
:::::.:: ::: ::.:.: . . ::.::::::.:.::::::.: ::.. .
NP_073 RNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLTFVQ
110 120 130 140 150 160
180 190 200 210 220
pF1KB9 --CGGGGGGLPG------ALFSEAVLLSPGGASAALSSSGDSP--SPASTWSCTNSPAPS
: : . . : ... :.. :: .: . : : : . :. :. .
NP_073 NLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELTTPPGHG
170 180 190 200 210 220
230 240 250 260 270
pF1KB9 SSVSSNSTSPYS-CT-----LSPASPAGSDMDYWQP--PPPDKHRYAPHLPIARDCI
. .:.: .::. :. .:: .. .. : :::
NP_073 TLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQEETLDYGK
230 240 250 260 270 280
NP_073 NYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAVFHN
290 300 310 320 330
>>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa)
initn: 331 init1: 245 opt: 267 Z-score: 218.4 bits: 48.4 E(85289): 2e-05
Smith-Waterman score: 267; 33.3% identity (59.4% similar) in 192 aa overlap (89-271:66-244)
60 70 80 90 100 110
pF1KB9 AGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKAN
.:.: :. .. : ..:.. .::.:::
NP_067 SRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKR-RGPKKKKMTKARLERFR-ARRVKAN
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB9 NRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGG
:::.:::.:: ::: ::.:.: . . ::.::::::.:.::::::.:.:. .. : :
NP_067 ARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKG
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB9 GGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTW---SCTNSPAPSSSVSSNSTSPYS
: : . . . .. : .. . .: :. .:: .:..: .. . :
NP_067 -------FVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQS
160 170 180 190 200
240 250 260 270
pF1KB9 CTLSPASPAG---SDMDYWQPP---PPDKHRYAPHLPIARDCI
: :. : : . . . .: . .. ::: ::
NP_067 PGL-PSPPYGHMETHLLHLKPQVFKSLGESSFGSHLP---DCSTPPYEGPLTPPLSISGN
210 220 230 240 250 260
NP_067 FSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQAGTPRYDVPIDMSYDSYPHHGIG
270 280 290 300 310 320
>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom (354 aa)
initn: 262 init1: 209 opt: 262 Z-score: 214.2 bits: 47.8 E(85289): 3.4e-05
Smith-Waterman score: 276; 36.0% identity (56.5% similar) in 214 aa overlap (24-225:84-282)
10 20 30 40 50
pF1KB9 MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARR
:: :.: : : ..: : . .::
NP_005 SLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGA-----SEAAAPRDEVDGRGELVRR
60 70 80 90 100
60 70 80 90 100 110
pF1KB9 QRGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTR
. :. ... . : : . . :. :.: : . :: :: : .. :. ..: :
NP_005 SSGGASSSKSPGPVKVREQLCKLKG--GVVVD-ELGCSRQRAPS-----SKQVNGVQKQR
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB9 RLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADH
:: :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: ::.: :. .
NP_005 RLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPS-
170 180 190 200 210
180 190 200 210 220
pF1KB9 CGGGGGGLPGA--------LFSEAVLLSPGG---ASAALSSSGDSPSPASTWSC-TNSPA
:: : : : . : . .: :..: ..:: : :. :: : :
NP_005 -GGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSA
220 230 240 250 260 270
230 240 250 260 270
pF1KB9 PSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI
:.:.
NP_005 PASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSD
280 290 300 310 320 330
>>NP_835455 (OMIM: 607194,609069,615935) pancreas transc (328 aa)
initn: 262 init1: 171 opt: 236 Z-score: 194.9 bits: 44.1 E(85289): 0.00041
Smith-Waterman score: 244; 30.8% identity (52.3% similar) in 266 aa overlap (2-254:52-275)
10 20 30
pF1KB9 MFVKSETLELKEEEDVLVLLGSASPALA-AL
:.. . : .. . .:: : :: ::
NP_835 DEDDFFTDQSSRDPLEDGDELLADEQAEVEFLSHQLHEYCYRDGACLLLQPAPPAAPLAL
30 40 50 60 70 80
40 50 60 70 80
pF1KB9 TPLSSSADEEEEEEPGASGGARRQRGAEAG-----QGARGGV----AAGAEGCRP-ARLL
.: ::.. : .. :..:: . :: : :. . ::: : :::
NP_835 APPSSGGLGEPDD--GGGGGYCCETGAPPGGFPYSPGSPPSCLAYPCAGAAVLSPGARLR
90 100 110 120 130
90 100 110 120 130 140
pF1KB9 GLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLP
:: . : :..: . ... .... :. :: ::: ::...: :...:: .:
NP_835 GL-------SGAAAAAARRRRRVRSEAELQQLRQ-AANVRERRRMQSINDAFEGLRSHIP
140 150 160 170 180 190
150 160 170 180 190
pF1KB9 TFPEDAKLTKIETLRFAHNYIWALTETLRLADHC--GGGGGGLPGALFSEAVLLSPGGAS
:.: . .:.:..:::.: .:: :.: .. :: :::.:: : :::..
NP_835 TLPYEKRLSKVDTLRLAIGYINFLSELVQ-ADLPLRGGGAGGCGG----------PGGGG
200 210 220 230 240
200 210 220 230 240 250
pF1KB9 AALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDK
.::::. :.. . : . ::. :: :: ::
NP_835 ---RLGGDSPG------------------SQAQKVIICHRGTRSPSPSDPDYGLPPLAGH
250 260 270
260 270
pF1KB9 HRYAPHLPIARDCI
NP_835 SLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSSFNNIENEPPFEFVS
280 290 300 310 320
272 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:50:59 2016 done: Fri Nov 4 17:51:01 2016
Total Scan time: 9.260 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]