Result of FASTA (omim) for
pF1KB8523
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8523, 937 aa
1>>>pF1KB8523 937 - 937 aa - 937 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1982+/-0.000676; mu= 7.0048+/- 0.041
mean_var=230.4898+/-46.485, 0's: 0 Z-trim(110.5): 589 B-trim: 76 in 1/53
Lambda= 0.084479
statistics sampled from 18220 (18911) to 18220 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.549), E-opt: 0.2 (0.222), width: 16
Scan time: 11.500
The best scores are: opt bits E(85289)
NP_085072 (OMIM: 602108) matrilin-2 isoform b prec ( 937) 6497 806.9 0
NP_002371 (OMIM: 602108) matrilin-2 isoform a prec ( 956) 5990 745.1 3.8e-214
XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 ( 799) 4622 578.3 5.2e-164
XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 ( 818) 4622 578.3 5.3e-164
XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 ( 896) 4325 542.2 4.5e-153
NP_001304677 (OMIM: 602108) matrilin-2 isoform c p ( 915) 3818 480.4 1.8e-134
NP_002372 (OMIM: 140600,602109,607078,608728) matr ( 486) 1239 165.8 4.9e-40
XP_016883602 (OMIM: 603897) PREDICTED: matrilin-4 ( 575) 1194 160.4 2.4e-38
XP_005260654 (OMIM: 603897) PREDICTED: matrilin-4 ( 581) 1194 160.4 2.5e-38
NP_003824 (OMIM: 603897) matrilin-4 isoform 1 prec ( 581) 1194 160.4 2.5e-38
NP_766638 (OMIM: 611746) signal peptide, CUB and E ( 988) 1046 142.6 9.6e-33
NP_001290065 (OMIM: 614708) signal peptide, CUB an ( 992) 1042 142.1 1.3e-32
XP_016883603 (OMIM: 603897) PREDICTED: matrilin-4 ( 534) 1012 138.1 1.1e-31
NP_085080 (OMIM: 603897) matrilin-4 isoform 2 prec ( 540) 1012 138.2 1.1e-31
NP_689966 (OMIM: 614708) signal peptide, CUB and E ( 993) 984 135.0 1.8e-30
XP_016859597 (OMIM: 150390) PREDICTED: latent-tran (1681) 929 128.5 2.7e-28
XP_011531158 (OMIM: 150390) PREDICTED: latent-tran (1682) 929 128.5 2.7e-28
XP_016883604 (OMIM: 603897) PREDICTED: matrilin-4 ( 493) 890 123.2 3.1e-27
NP_085095 (OMIM: 603897) matrilin-4 isoform 3 prec ( 499) 890 123.3 3.2e-27
XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364) 898 124.7 3.2e-27
NP_001400 (OMIM: 604266) multiple epidermal growth (1541) 898 124.7 3.5e-27
XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560) 898 124.7 3.5e-27
XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603) 898 124.7 3.6e-27
XP_006710469 (OMIM: 604266) PREDICTED: multiple ep (1436) 893 124.1 5.1e-27
XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559) 890 123.8 6.9e-27
XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639) 853 119.3 1.6e-25
NP_002370 (OMIM: 115437) cartilage matrix protein ( 496) 805 112.9 4.1e-24
XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680) 801 112.9 1.3e-23
NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 799 112.6 1.4e-23
NP_000618 (OMIM: 150390) latent-transforming growt (1395) 799 112.6 1.4e-23
XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666) 799 112.7 1.6e-23
XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668) 799 112.7 1.6e-23
XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669) 799 112.7 1.6e-23
XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720) 799 112.7 1.6e-23
NP_996826 (OMIM: 150390) latent-transforming growt (1721) 799 112.7 1.6e-23
XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722) 799 112.7 1.6e-23
XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 763 108.3 3.2e-22
XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 759 107.7 4.1e-22
XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595) 747 106.3 1.2e-21
XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 747 106.4 1.4e-21
XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 742 105.7 1.8e-21
XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 (2766) 747 106.6 1.8e-21
XP_016882864 (OMIM: 608529) PREDICTED: fibrillin-3 (2768) 747 106.6 1.8e-21
XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 (2777) 747 106.6 1.8e-21
XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 (2789) 747 106.6 1.8e-21
XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 742 105.7 1.8e-21
XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 (2809) 747 106.6 1.8e-21
NP_001308360 (OMIM: 608529) fibrillin-3 precursor (2809) 747 106.6 1.8e-21
NP_115823 (OMIM: 608529) fibrillin-3 precursor [Ho (2809) 747 106.6 1.8e-21
XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 (2851) 747 106.6 1.9e-21
>>NP_085072 (OMIM: 602108) matrilin-2 isoform b precurso (937 aa)
initn: 6497 init1: 6497 opt: 6497 Z-score: 4299.6 bits: 806.9 E(85289): 0
Smith-Waterman score: 6497; 99.9% identity (100.0% similar) in 937 aa overlap (1-937:1-937)
10 20 30 40 50 60
pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_085 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
850 860 870 880 890 900
910 920 930
pF1KB8 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
:::::::::::::::::::::::::::::::::::::
NP_085 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
910 920 930
>>NP_002371 (OMIM: 602108) matrilin-2 isoform a precurso (956 aa)
initn: 6483 init1: 5990 opt: 5990 Z-score: 3965.6 bits: 745.1 E(85289): 3.8e-214
Smith-Waterman score: 6449; 97.9% identity (98.0% similar) in 956 aa overlap (1-937:1-956)
10 20 30 40 50 60
pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_002 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
790 800 810 820 830 840
850 860 870 880
pF1KB8 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH
:::::::::::::::::::: :::::::::::::::::::::
NP_002 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH
850 860 870 880 890 900
890 900 910 920 930
pF1KB8 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
910 920 930 940 950
>>XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 isof (799 aa)
initn: 7659 init1: 4618 opt: 4622 Z-score: 3065.5 bits: 578.3 E(85289): 5.2e-164
Smith-Waterman score: 5314; 85.1% identity (85.3% similar) in 937 aa overlap (1-937:1-799)
10 20 30 40 50 60
pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
:::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKS------------
610 620 630 640
670 680 690 700 710 720
pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
XP_016 ------------------------------------------------------------
730 740 750 760 770 780
pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
XP_016 ------------------------------------------------------------
790 800 810 820 830 840
pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ------ITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
650 660 670 680 690 700
850 860 870 880 890 900
pF1KB8 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
710 720 730 740 750 760
910 920 930
pF1KB8 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
:::::::::::::::::::::::::::::::::::::
XP_016 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
770 780 790
>>XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 isof (818 aa)
initn: 5111 init1: 4618 opt: 4622 Z-score: 3065.3 bits: 578.3 E(85289): 5.3e-164
Smith-Waterman score: 5266; 83.4% identity (83.6% similar) in 956 aa overlap (1-937:1-818)
10 20 30 40 50 60
pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
:::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKS------------
610 620 630 640
670 680 690 700 710 720
pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
XP_005 ------------------------------------------------------------
730 740 750 760 770 780
pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
XP_005 ------------------------------------------------------------
790 800 810 820 830 840
pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ------ITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
650 660 670 680 690 700
850 860 870 880
pF1KB8 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH
:::::::::::::::::::: :::::::::::::::::::::
XP_005 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH
710 720 730 740 750 760
890 900 910 920 930
pF1KB8 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
770 780 790 800 810
>>XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 isof (896 aa)
initn: 4325 init1: 4325 opt: 4325 Z-score: 2869.2 bits: 542.2 E(85289): 4.5e-153
Smith-Waterman score: 6090; 95.5% identity (95.6% similar) in 937 aa overlap (1-937:1-896)
10 20 30 40 50 60
pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
:::::::::::::::::::
XP_016 -----------------------------------------RINYCALNKPGCEHECVNM
370
430 440 450 460 470 480
pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
740 750 760 770 780 790
850 860 870 880 890 900
pF1KB8 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
800 810 820 830 840 850
910 920 930
pF1KB8 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
:::::::::::::::::::::::::::::::::::::
XP_016 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
860 870 880 890
>>NP_001304677 (OMIM: 602108) matrilin-2 isoform c precu (915 aa)
initn: 4311 init1: 3818 opt: 3818 Z-score: 2535.1 bits: 480.4 E(85289): 1.8e-134
Smith-Waterman score: 6042; 93.6% identity (93.7% similar) in 956 aa overlap (1-937:1-915)
10 20 30 40 50 60
pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
:::::::::::::::::::
NP_001 -----------------------------------------RINYCALNKPGCEHECVNM
370
430 440 450 460 470 480
pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
740 750 760 770 780 790
850 860 870 880
pF1KB8 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH
:::::::::::::::::::: :::::::::::::::::::::
NP_001 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH
800 810 820 830 840 850
890 900 910 920 930
pF1KB8 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
860 870 880 890 900 910
>>NP_002372 (OMIM: 140600,602109,607078,608728) matrilin (486 aa)
initn: 984 init1: 649 opt: 1239 Z-score: 839.8 bits: 165.8 E(85289): 4.9e-40
Smith-Waterman score: 1249; 45.5% identity (67.3% similar) in 444 aa overlap (3-414:8-449)
10 20 30
pF1KB8 MEKMLAGCFLLILGQIVLLPAEA----------RERSRGRSISRGRH--------
. : : .::.: ..:::. : : ..:: . : ::.
NP_002 MPRPAPARRLPG-LLLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDG
10 20 30 40 50
40 50 60 70 80 90
pF1KB8 ----ARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDV
. ..: : . :... :::::::::::: ...::: :. :.. :::::
NP_002 APASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPAD
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB8 TRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEG
:::....:.:::: ::.:... :. ...:: :. ::::::.::::: :.. ::. :
NP_002 TRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAG
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB8 ARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHE
:: :.:.: .:::::::::.: ::::.:. .:: ..:.:: ..:. .:: ..::: :
NP_002 AREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLE
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB8 DHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCI-NIPGSYVCRCKQGYILNS
.::: : ... :: :.: ::. .:. : :.: : :: . :.. :.:.::: ::.
NP_002 EHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNA
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB8 DQTTCRIQDLCAMEDHNCEQLCVN-VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGC
:. :: : ::.. :.::..::: ::. :.:: ::.: :: : : : : :: .:::
NP_002 DKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGC
300 310 320 330 340 350
340 350 360 370 380
pF1KB8 EHECVNA-DGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGCQHECVNTDD-SYSCHCLK
.: ::: ::. :.:.::..:: :.:::. : :: ..::::: ::. :: : :
NP_002 QHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYP
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB8 GFTLNPDKKTC------RRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR
:.::: ::::: ::. . . :::
NP_002 GYTLNEDKKTCSATEEARRL-VSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKI
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB8 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD
NP_002 NEYGQIHR
480
>>XP_016883602 (OMIM: 603897) PREDICTED: matrilin-4 isof (575 aa)
initn: 2431 init1: 1182 opt: 1194 Z-score: 809.3 bits: 160.4 E(85289): 2.4e-38
Smith-Waterman score: 1344; 34.3% identity (51.9% similar) in 807 aa overlap (43-848:20-539)
20 30 40 50 60 70
pF1KB8 LGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHD
: : :.. ::::.::::::: .
XP_016 MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFE
10 20 30 40
80 90 100 110 120 130
pF1KB8 YAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLST
. ...:.. .:. :..::..::::..::.: :.. : :..:.:. ..:::.. . :.
XP_016 FETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQ
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB8 GTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIF
:::::::::::.:.::: :::::: .: :::: .::::::::: ::::::.:: :: :.
XP_016 GTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIY
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB8 AIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHF
:.:: ..: ..:....: : ..::::: .:. :. . ::..::
XP_016 AVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLC---------------
170 180 190 200 210
260 270 280 290 300 310
pF1KB8 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
XP_016 ------------------------------------------------------------
320 330 340 350 360 370
pF1KB8 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGC
:.: :: .:::::.:::. :::.:.:. ::.:. :...: ::::. .::.:
XP_016 -------AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC
220 230 240 250 260
380 390 400 410 420 430
pF1KB8 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY
:::::.: :: :::
XP_016 QHECVST-------------------------------PGGP------------RCH---
270 280
440 450 460 470 480 490
pF1KB8 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD
XP_016 ------------------------------------------------------------
500 510 520 530 540 550
pF1KB8 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF
: ::: :
XP_016 -----------------CREGH----D---------------------------------
560 570 580 590 600 610
pF1KB8 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK
:. ::..:. .:.:...::::: :.
XP_016 ----LQPDGRSCQVRDLCNGVDHGCE-----------------FQ---------------
290 300 310
620 630 640 650 660 670
pF1KB8 STHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFE
::..: :: : : :: : ::. :..: :: .:::...:::::. .:::
XP_016 ---------CVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFE
320 330 340 350 360
680 690 700 710 720 730
pF1KB8 VVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGS
.::.::. :.: : .::...::::.:.:..:.::: : ...: ..:.:: ..:: .:.
XP_016 LVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGT
370 380 390 400 410 420
740 750 760 770 780 790
pF1KB8 MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAV
::::::.:: :.::....:::: . :::...::::::.:::.: ::..:: .::.::::
XP_016 MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAV
430 440 450 460 470 480
800 810 820 830 840 850
pF1KB8 GVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQ-DSPAGE
:::::.: ::.::::::.. :. :: ::.:: .. :.:. .:: : : . ::
XP_016 GVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCEC
490 500 510 520 530 540
860 870 880 890 900 910
pF1KB8 LPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANE
XP_016 ESLVEFQGRTLGALESLTLNHILWGWWRGLEGK
550 560 570
>>XP_005260654 (OMIM: 603897) PREDICTED: matrilin-4 isof (581 aa)
initn: 1182 init1: 1182 opt: 1194 Z-score: 809.2 bits: 160.4 E(85289): 2.5e-38
Smith-Waterman score: 1350; 33.1% identity (50.3% similar) in 892 aa overlap (43-934:20-577)
20 30 40 50 60 70
pF1KB8 LGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHD
: : :.. ::::.::::::: .
XP_005 MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFE
10 20 30 40
80 90 100 110 120 130
pF1KB8 YAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLST
. ...:.. .:. :..::..::::..::.: :.. : :..:.:. ..:::.. . :.
XP_005 FETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQ
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB8 GTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIF
:::::::::::.:.::: :::::: .: :::: .::::::::: ::::::.:: :: :.
XP_005 GTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIY
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB8 AIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHF
:.:: ..: ..:....: : ..::::: .:. :. . ::..::
XP_005 AVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLC---------------
170 180 190 200 210
260 270 280 290 300 310
pF1KB8 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
XP_005 ------------------------------------------------------------
320 330 340 350 360 370
pF1KB8 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGC
:.: :: .:::::.:::. :::.:.:. ::.:. :...: ::::. .::.:
XP_005 -------AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC
220 230 240 250 260
380 390 400 410 420 430
pF1KB8 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY
:::::.: :: :::
XP_005 QHECVST-------------------------------PGGP------------RCH---
270 280
440 450 460 470 480 490
pF1KB8 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD
XP_005 ------------------------------------------------------------
500 510 520 530 540 550
pF1KB8 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF
: ::: :
XP_005 -----------------CREGH------------------------------D-------
560 570 580 590 600 610
pF1KB8 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK
:. ::..:. .:.:...::::: :.
XP_005 ----LQPDGRSCQVRDLCNGVDHGCE-----------------FQ---------------
290 300 310
620 630 640 650 660 670
pF1KB8 STHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFE
::..: :: : : :: : ::. :..: :: .:::...:::::. .:::
XP_005 ---------CVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFE
320 330 340 350 360
680 690 700 710 720 730
pF1KB8 VVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGS
.::.::. :.: : .::...::::.:.:..:.::: : ...: ..:.:: ..:: .:.
XP_005 LVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGT
370 380 390 400 410 420
740 750 760 770 780 790
pF1KB8 MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAV
::::::.:: :.::....:::: . :::...::::::.:::.: ::..:: .::.::::
XP_005 MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAV
430 440 450 460 470 480
800 810 820 830 840 850
pF1KB8 GVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGEL
:::::.: ::.::::::.. :. :: ::.:: .. :.:. .:: : : .
XP_005 GVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTE-------
490 500 510 520 530
860 870 880 890 900 910
pF1KB8 PKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEE
::: : :.::.:. ::. .
XP_005 --------------------LRS---------P-----------CECESLVEFQGRTLGA
540 550
920 930
pF1KB8 VRKLTQRLEEMTQRMEALENRLRYR
...:: : ..: :.: :::.:
XP_005 LESLTLNLAQLTARLEDLENQLANQK
560 570 580
>>NP_003824 (OMIM: 603897) matrilin-4 isoform 1 precurso (581 aa)
initn: 1182 init1: 1182 opt: 1194 Z-score: 809.2 bits: 160.4 E(85289): 2.5e-38
Smith-Waterman score: 1350; 33.1% identity (50.3% similar) in 892 aa overlap (43-934:20-577)
20 30 40 50 60 70
pF1KB8 LGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHD
: : :.. ::::.::::::: .
NP_003 MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFE
10 20 30 40
80 90 100 110 120 130
pF1KB8 YAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLST
. ...:.. .:. :..::..::::..::.: :.. : :..:.:. ..:::.. . :.
NP_003 FETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQ
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB8 GTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIF
:::::::::::.:.::: :::::: .: :::: .::::::::: ::::::.:: :: :.
NP_003 GTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIY
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB8 AIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHF
:.:: ..: ..:....: : ..::::: .:. :. . ::..::
NP_003 AVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLC---------------
170 180 190 200 210
260 270 280 290 300 310
pF1KB8 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
NP_003 ------------------------------------------------------------
320 330 340 350 360 370
pF1KB8 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGC
:.: :: .:::::.:::. :::.:.:. ::.:. :...: ::::. .::.:
NP_003 -------AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC
220 230 240 250 260
380 390 400 410 420 430
pF1KB8 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY
:::::.: :: :::
NP_003 QHECVST-------------------------------PGGP------------RCH---
270 280
440 450 460 470 480 490
pF1KB8 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD
NP_003 ------------------------------------------------------------
500 510 520 530 540 550
pF1KB8 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF
: ::: :
NP_003 -----------------CREGH------------------------------D-------
560 570 580 590 600 610
pF1KB8 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK
:. ::..:. .:.:...::::: :.
NP_003 ----LQPDGRSCQVRDLCNGVDHGCE-----------------FQ---------------
290 300 310
620 630 640 650 660 670
pF1KB8 STHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFE
::..: :: : : :: : ::. :..: :: .:::...:::::. .:::
NP_003 ---------CVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFE
320 330 340 350 360
680 690 700 710 720 730
pF1KB8 VVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGS
.::.::. :.: : .::...::::.:.:..:.::: : ...: ..:.:: ..:: .:.
NP_003 LVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGT
370 380 390 400 410 420
740 750 760 770 780 790
pF1KB8 MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAV
::::::.:: :.::....:::: . :::...::::::.:::.: ::..:: .::.::::
NP_003 MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAV
430 440 450 460 470 480
800 810 820 830 840 850
pF1KB8 GVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGEL
:::::.: ::.::::::.. :. :: ::.:: .. :.:. .:: : : .
NP_003 GVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTE-------
490 500 510 520 530
860 870 880 890 900 910
pF1KB8 PKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEE
::: : :.::.:. ::. .
NP_003 --------------------LRS---------P-----------CECESLVEFQGRTLGA
540 550
920 930
pF1KB8 VRKLTQRLEEMTQRMEALENRLRYR
...:: : ..: :.: :::.:
NP_003 LESLTLNLAQLTARLEDLENQLANQK
560 570 580
937 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 16:34:04 2016 done: Sat Nov 5 16:34:05 2016
Total Scan time: 11.500 Total Display time: 0.310
Function used was FASTA [36.3.4 Apr, 2011]