FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8248, 235 aa
  1>>>pF1KB8248 235 - 235 aa - 235 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.0718+/-0.000347; mu= 15.0612+/- 0.022
 mean_var=60.6733+/-11.845, 0's: 0 Z-trim(114.9): 4  B-trim: 0 in 0/52
 Lambda= 0.164655
 statistics sampled from 24992 (24996) to 24992 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.691), E-opt: 0.2 (0.293), width:  16
 Scan time:  4.750

The best scores are:                                      opt bits E(85289)
NP_064543 (OMIM: 606492) exosome complex component ( 235) 1518 368.8 4.5e-102
XP_011515436 (OMIM: 606491) PREDICTED: exosome com ( 147)  231 63.0 3.3e-10
NP_061910 (OMIM: 606491) exosome complex component ( 245)  231 63.1   5e-10
NP_478126 (OMIM: 606490) exosome complex component ( 272)  188 52.9 6.5e-07


>>NP_064543 (OMIM: 606492) exosome complex component RRP  (235 aa)
 initn: 1518 init1: 1518 opt: 1518  Z-score: 1953.5  bits: 368.8 E(85289): 4.5e-102
Smith-Waterman score: 1518; 100.0% identity (100.0% similar) in 235 aa overlap (1-235:1-235)

               10        20        30        40        50        60
pF1KB8 MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 PAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 PAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 QVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 QVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAV
              130       140       150       160       170       180

              190       200       210       220       230     
pF1KB8 LTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 LTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS
              190       200       210       220       230     

>>XP_011515436 (OMIM: 606491) PREDICTED: exosome complex  (147 aa)
 initn: 227 init1: 190 opt: 231  Z-score: 304.3  bits: 63.0 E(85289): 3.3e-10
Smith-Waterman score: 231; 36.4% identity (63.6% similar) in 121 aa overlap (98-216:5-123)

        70        80        90       100       110       120       
pF1KB8 KEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAG
                                     .:.: ::..:  ::::..: . .::..  :
XP_011                           MGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADG
                                         10        20        30    

       130       140       150       160        170       180      
pF1KB8 SLLACCLNAACMALVDAGVPMRALFCGVACALD-SDGTLVLDPTSKQEKEARAVLTFALD
       .  : :.::: .:..:::.::: . :  ::.    ::: . : .  .:  .   :..:: 
XP_011 GTYAACVNAATLAVLDAGIPMRDFVC--ACSAGFVDGTALADLSHVEEAAGGPQLALALL
           40        50        60          70        80        90  

        190       200       210        220       230          
pF1KB8 SVERKLLMSSTKGLYSDTELQQCL-AAAQAASQHVFRFYRESLQRRYSKS     
        .  .. .    .   . .:.. : ::::::                        
XP_011 PASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD
            100       110       120       130       140       

>>NP_061910 (OMIM: 606491) exosome complex component RRP  (245 aa)
 initn: 284 init1: 190 opt: 231  Z-score: 301.0  bits: 63.1 E(85289): 5e-10
Smith-Waterman score: 300; 33.3% identity (60.8% similar) in 204 aa overlap (28-216:22-221)

               10        20        30        40        50        60
pF1KB8 MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYG
                                  ::..  ....... :::: . ::.:..:: :::
NP_061       MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYG
                     10        20        30        40        50    

                          70        80        90         100       
pF1KB8 PAEVKVSKE-----------IFNKATLEVILRPKIGLPGVAEKSRER--LIRNTCEAVVL
       : :.. :.             ...::. .  : .   :   .:: :    .:.: ::..:
NP_061 PHEIRGSRARALPDRALVNCQYSSATFSTGERKR--RPHGDRKSCEMGLQLRQTFEAAIL
           60        70        80          90       100       110  

       110       120       130       140       150       160       
pF1KB8 GTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALD-SDGTLV
         ::::..: . .::..  :.  : :.::: .:..:::.::: . :  ::.    ::: .
NP_061 TQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVC--ACSAGFVDGTAL
            120       130       140       150         160       170

        170       180       190       200       210        220     
pF1KB8 LDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCL-AAAQAASQHVFRFYR
        : .  .:  .   :..::  .  .. .    .   . .:.. : ::::::         
NP_061 ADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDR
              180       190       200       210       220       230

         230          
pF1KB8 ESLQRRYSKS     
                      
NP_061 VVRQHVREASILLGD
              240     

>>NP_478126 (OMIM: 606490) exosome complex component MTR  (272 aa)
 initn: 182 init1: 121 opt: 188  Z-score: 245.1  bits: 52.9 E(85289): 6.5e-07
Smith-Waterman score: 213; 30.0% identity (53.4% similar) in 253 aa overlap (3-230:12-261)

                        10        20        30        40        50 
pF1KB8          MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGD
                  ::..      :..  . . : :   ::    . .:::.  ::: .  : 
NP_478 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDP-TRLRPVYARAGLLSQAKGSAYLEAGG
               10        20        30         40        50         

              60        70            80                       90  
pF1KB8 TSVLAGVYGPAEVKVSKEIFNKA----TLEVILR----------PKIGL-----PGVAEK
       :.:: .: :: ... ...  . :       . ::          :  :      ::  :.
NP_478 TKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEE
      60        70        80        90       100       110         

             100        110       120       130       140       150
pF1KB8 SRERL-IRNTCE-AVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRA
        .  : .... : :: ::  .::... :   .. :.:: ::  :.:: .::.:::: :  
NP_478 RELALALQEALEPAVRLGR-YPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYD
     120       130        140       150       160       170        

                160       170       180       190         200      
pF1KB8 LF--CGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKL--LMSSTKGLYSDTEL
       :   ::.. :     : .::::  .:..: : :: ::  :  ..  :..: .:  ...  
NP_478 LVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTES-W
      180       190       200       210       220       230        

        210       220       230           
pF1KB8 QQCLAAAQAASQHVFRFYRESLQRRYSKS      
        . .  .  . :...   ..:: :           
NP_478 AEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP
       240       250       260       270  




235 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:58:48 2016 done: Fri Nov  4 10:58:48 2016
 Total Scan time:  4.750 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]