Result of FASTA (omim) for
pF1KB8196
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8196, 458 aa
1>>>pF1KB8196 458 - 458 aa - 458 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5003+/-0.000316; mu= 12.8616+/- 0.020
mean_var=105.3776+/-21.425, 0's: 0 Z-trim(118.7): 23 B-trim: 0 in 0/53
Lambda= 0.124940
statistics sampled from 31904 (31927) to 31904 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.374), width: 16
Scan time: 7.240
The best scores are: opt bits E(85289)
NP_037379 (OMIM: 606441,610297) serine protease HT ( 458) 2982 547.9 2e-155
NP_001308657 (OMIM: 606441,610297) serine protease ( 426) 2430 448.4 1.7e-125
NP_001308656 (OMIM: 606441,610297) serine protease ( 436) 2065 382.6 1.1e-105
NP_659540 (OMIM: 606441,610297) serine protease HT ( 361) 1569 293.2 7.8e-79
NP_444272 (OMIM: 608785) serine protease HTRA3 iso ( 453) 1133 214.7 4.3e-55
NP_002766 (OMIM: 600142,602194,610149,616779) seri ( 480) 1107 210.0 1.2e-53
NP_710159 (OMIM: 610700) serine protease HTRA4 pre ( 476) 1001 190.9 6.5e-48
NP_001284488 (OMIM: 608785) serine protease HTRA3 ( 357) 884 169.7 1.1e-41
XP_011511898 (OMIM: 608785) PREDICTED: serine prot ( 373) 884 169.7 1.2e-41
XP_011542733 (OMIM: 610700) PREDICTED: serine prot ( 380) 773 149.7 1.3e-35
XP_011542734 (OMIM: 610700) PREDICTED: serine prot ( 343) 619 121.9 2.6e-27
>>NP_037379 (OMIM: 606441,610297) serine protease HTRA2, (458 aa)
initn: 2982 init1: 2982 opt: 2982 Z-score: 2911.3 bits: 547.9 E(85289): 2e-155
Smith-Waterman score: 2982; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
370 380 390 400 410 420
430 440 450
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
::::::::::::::::::::::::::::::::::::::
NP_037 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
430 440 450
>>NP_001308657 (OMIM: 606441,610297) serine protease HTR (426 aa)
initn: 2757 init1: 2430 opt: 2430 Z-score: 2374.0 bits: 448.4 E(85289): 1.7e-125
Smith-Waterman score: 2697; 93.0% identity (93.0% similar) in 458 aa overlap (1-458:1-426)
10 20 30 40 50 60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
::::::::::: :::::::::::::::::
NP_001 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM
370 380
430 440 450
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
::::::::::::::::::::::::::::::::::::::
NP_001 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
390 400 410 420
>>NP_001308656 (OMIM: 606441,610297) serine protease HTR (436 aa)
initn: 2743 init1: 2061 opt: 2065 Z-score: 2018.3 bits: 382.6 E(85289): 1.1e-105
Smith-Waterman score: 2667; 91.0% identity (91.0% similar) in 468 aa overlap (1-458:1-436)
10 20 30 40 50 60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
250 260 270 280 290 300
310 320 330 340 350
pF1KB8 IDFGNSGGPLVNL----------DGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNS
::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 IDFGNSGGPLVNLARELGAVSLQDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 SSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPG
::::::::::::::::::::: :::::::
NP_001 SSGISGSQRRYIGVMMLTLSP--------------------------------RAGLRPG
370 380
420 430 440 450
pF1KB8 DVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
390 400 410 420 430
>>NP_659540 (OMIM: 606441,610297) serine protease HTRA2, (361 aa)
initn: 2325 init1: 1567 opt: 1569 Z-score: 1536.3 bits: 293.2 E(85289): 7.8e-79
Smith-Waterman score: 2139; 78.8% identity (78.8% similar) in 458 aa overlap (1-458:1-361)
10 20 30 40 50 60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTK---
190 200 210 220 230
250 260 270 280 290 300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
NP_659 ------------------------------------------------------------
310 320 330 340 350 360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 --FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
::::::::::: :::::::::::::::::
NP_659 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM
300 310 320
430 440 450
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
::::::::::::::::::::::::::::::::::::::
NP_659 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
330 340 350 360
>>NP_444272 (OMIM: 608785) serine protease HTRA3 isoform (453 aa)
initn: 885 init1: 634 opt: 1133 Z-score: 1110.1 bits: 214.7 E(85289): 4.3e-55
Smith-Waterman score: 1138; 45.2% identity (71.6% similar) in 454 aa overlap (19-456:10-451)
10 20 30 40 50
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
::... .:.: .: .: .:: : .:.:
NP_444 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
: ...: . : : : .: .. : : : : . :: .... : :: :..
NP_444 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
NP_444 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
110 120 130 140 150 160
180 190 200 210 220
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
NP_444 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_444 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
NP_444 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
. :. :. ..:.::. : :..::.. ::. .:.::.:. :. ...: .::..:.
NP_444 QDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG
350 360 370 380 390 400
410 420 430 440 450
pF1KB8 GLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
:.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:::
NP_444 GIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
410 420 430 440 450
>>NP_002766 (OMIM: 600142,602194,610149,616779) serine p (480 aa)
initn: 1103 init1: 869 opt: 1107 Z-score: 1084.4 bits: 210.0 E(85289): 1.2e-53
Smith-Waterman score: 1107; 53.8% identity (81.6% similar) in 316 aa overlap (140-455:162-476)
110 120 130 140 150 160
pF1KB8 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
: : : .:::::::::: :::::.::.. .
NP_002 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB8 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
:: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: :::
NP_002 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB8 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
: ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
NP_002 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB8 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN
....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... ..
NP_002 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB8 SSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRP
.. : . ....:::. :..:. : ::. :. .:::: :. : .:: .::. .::.
NP_002 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE
380 390 400 410 420 430
410 420 430 440 450
pF1KB8 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
.:::..:. : : .:.:: .... .: : . .::: : . . : ::
NP_002 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
440 450 460 470 480
>>NP_710159 (OMIM: 610700) serine protease HTRA4 precurs (476 aa)
initn: 926 init1: 769 opt: 1001 Z-score: 981.2 bits: 190.9 E(85289): 6.5e-48
Smith-Waterman score: 1002; 44.1% identity (71.2% similar) in 392 aa overlap (71-455:94-473)
50 60 70 80 90
pF1KB8 SGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPG-------PRAQLTAVTPDTRTR
:: :: : .. : ::
NP_710 DLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTY
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADV
. ...:: : :: :: . ::. : .. .: : : .::::: :
NP_710 PSMCALRAENRA--ARRLGKVPAVPVQ-WGNC-GDTGTRSAGPL------RRNYNFIAAV
130 140 150 160 170
160 170 180 190 200 210
pF1KB8 VEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSG
:::.::.::.... : .: ::. .::::.:. ::::.:::::: ... ..: : .:
NP_710 VEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB8 DTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSG
::::: .: :.:...:... ::.: ::::.:.: ::::::.::::.:::: :.:
NP_710 ARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB8 IVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
:::. :: ...::. .....:.: ::.:..::::::::::::.:::::...:: ::::::
NP_710 IVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAI
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB8 PSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLI
::::.:.:: . .... .: . :...:.:..::.:. . ::... :.::::. :: .
NP_710 PSDRVRQFLAE-YHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYV
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB8 HKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVT
::. :. :. .::: :::. :. . . .. :: .:. ..: :.. . ::...: : :
NP_710 CKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVI
420 430 440 450 460 470
pF1KB8 PEVTE
::
NP_710 PETIN
>>NP_001284488 (OMIM: 608785) serine protease HTRA3 isof (357 aa)
initn: 678 init1: 634 opt: 884 Z-score: 869.1 bits: 169.7 E(85289): 1.1e-41
Smith-Waterman score: 889; 48.1% identity (70.7% similar) in 345 aa overlap (19-348:10-347)
10 20 30 40 50
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
::... .:.: .: .: .:: : .:.:
NP_001 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
: ...: . : : : .: .. : : : : . :: .... : :: :..
NP_001 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
NP_001 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
110 120 130 140 150 160
180 190 200 210 220
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
NP_001 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_001 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
NP_001 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
. :
NP_001 QDKQIKAPSLAVH
350
>>XP_011511898 (OMIM: 608785) PREDICTED: serine protease (373 aa)
initn: 634 init1: 634 opt: 884 Z-score: 868.8 bits: 169.7 E(85289): 1.2e-41
Smith-Waterman score: 889; 48.1% identity (70.7% similar) in 345 aa overlap (19-348:10-347)
10 20 30 40 50
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
::... .:.: .: .: .:: : .:.:
XP_011 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
: ...: . : : : .: .. : : : : . :: .... : :: :..
XP_011 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
XP_011 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
110 120 130 140 150 160
180 190 200 210 220
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
XP_011 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
XP_011 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
XP_011 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
. :
XP_011 QDKQIKAKHMDPSAAKAGAMRAGHMKSCC
350 360 370
>>XP_011542733 (OMIM: 610700) PREDICTED: serine protease (380 aa)
initn: 769 init1: 769 opt: 773 Z-score: 760.5 bits: 149.7 E(85289): 1.3e-35
Smith-Waterman score: 774; 46.6% identity (70.5% similar) in 292 aa overlap (71-352:94-375)
50 60 70 80 90
pF1KB8 SGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPG-------PRAQLTAVTPDTRTR
:: :: : .. : ::
XP_011 DLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTY
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADV
. ...:: : :: :: . ::. : .. .: : : .::::: :
XP_011 PSMCALRAENRA--ARRLGKVPAVPVQ-WGNC-GDTGTRSAGPL------RRNYNFIAAV
130 140 150 160 170
160 170 180 190 200 210
pF1KB8 VEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSG
:::.::.::.... : .: ::. .::::.:. ::::.:::::: ... ..: : .:
XP_011 VEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB8 DTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSG
::::: .: :.:...:... ::.: ::::.:.: ::::::.::::.:::: :.:
XP_011 ARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB8 IVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
:::. :: ...::. .....:.: ::.:..::::::::::::.:::::...:: ::::::
XP_011 IVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAI
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB8 PSDRLREFL---HRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHG
::::.:.:: :. . :....
XP_011 PSDRVRQFLAEYHEHQMKEAKTIAAQS
360 370 380
458 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:26:34 2016 done: Fri Nov 4 10:26:35 2016
Total Scan time: 7.240 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]