Result of FASTA (omim) for
pF1KB7926
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7926, 350 aa
1>>>pF1KB7926 350 - 350 aa - 350 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7567+/-0.000321; mu= -0.2823+/- 0.020
mean_var=299.3390+/-60.365, 0's: 0 Z-trim(125.3): 11 B-trim: 262 in 2/56
Lambda= 0.074130
statistics sampled from 48638 (48649) to 48638 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.836), E-opt: 0.2 (0.57), width: 16
Scan time: 10.320
The best scores are: opt bits E(85289)
NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 2353 264.1 3.3e-70
NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 1264 147.5 3.1e-35
NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 524 68.4 2e-11
NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 482 64.0 5.3e-10
XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10
NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 476 63.4 8.7e-10
XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10
XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10
XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10
>>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa)
initn: 2353 init1: 2353 opt: 2353 Z-score: 1381.5 bits: 264.1 E(85289): 3.3e-70
Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350)
10 20 30 40 50 60
pF1KB7 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 PLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
310 320 330 340 350
>>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa)
initn: 1264 init1: 1264 opt: 1264 Z-score: 753.4 bits: 147.5 E(85289): 3.1e-35
Smith-Waterman score: 1695; 78.3% identity (78.6% similar) in 350 aa overlap (1-350:1-275)
10 20 30 40 50 60
pF1KB7 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 PLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKV
:::::
NP_115 PLYNI-------------------------------------------------------
250 260 270 280 290 300
pF1KB7 LESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP
.:::::::::::::::::::::::::::::::::::::::
NP_115 --------------------SANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP
190 200 210 220
310 320 330 340 350
pF1KB7 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT
230 240 250 260 270
>>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa)
initn: 443 init1: 443 opt: 524 Z-score: 326.1 bits: 68.4 E(85289): 2e-11
Smith-Waterman score: 524; 38.9% identity (74.4% similar) in 211 aa overlap (117-322:30-236)
90 100 110 120 130 140
pF1KB7 EEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATT
.::: .....:. .:.: .: ::..::::
NP_116 MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATT
10 20 30 40 50
150 160 170 180 190 200
pF1KB7 ITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEERE
::::::::::::::... :. :: ::: .:.:::: :..::: .:::::::: .:.. :
NP_116 ITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSE
60 70 80 90 100 110
210 220 230 240 250 260
pF1KB7 KKQMHDFYKERGLE-VPKPAVPQPVPSSKGRSKKVLES----VFRIPPELDMSLLLEFIG
.:....::. :::. : .:. .:. :. : . .. .: .:. : :: ..
NP_116 EKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLN--LCLERLS
120 130 140 150 160 170
270 280 290 300 310 320
pF1KB7 ANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
... .. . :..:.:: : .: . :... : ... :.: .:... ...: ...:...
NP_116 SGKDKNK-SVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQ-HVQLLFDNEVLPDHMTMKQ
180 190 200 210 220 230
330 340 350
pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
:
NP_116 IWLSRWFGKPSPLLLQYSVKEKRR
240 250
>>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa)
initn: 494 init1: 393 opt: 482 Z-score: 300.5 bits: 64.0 E(85289): 5.3e-10
Smith-Waterman score: 482; 39.2% identity (66.5% similar) in 209 aa overlap (123-322:7-209)
100 110 120 130 140 150
pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH
:...::.:...: .: ::.:::::: ::::
NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLH
10 20 30
160 170 180 190 200 210
pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD
.:::.::::.. :. :: :.. ::.:.:: ::: :. ::::::::: .: . : :. .:
NP_005 SFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRD
40 50 60 70 80 90
220 230 240 250 260
pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANE-----GTG
:: . .:.. :.. :.. . :. : . .:: .::. :. .
NP_005 FY------AAHPSADAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKD
100 110 120 130 140 150
270 280 290 300 310 320
pF1KB7 HFKPLE----KKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIR
. : : :...: . :. :..:::: :: . . :.:.. .. :..: :: .:
NP_005 KEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIA
160 170 180 190 200 210
330 340 350
pF1KB7 RAIGDAAMQDGLLVLHYGLVVSPLKIT
NP_005 YIYTWRRNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSS
220 230 240 250 260 270
>>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10
Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211)
100 110 120 130 140 150
pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH
:...::.:...:..: ::.::::::.::::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH
10 20 30
160 170 180 190 200 210
pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD
.:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .:
XP_005 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP
:: . : . : :.. :.. . . . . .:: .:: :: . . :
XP_005 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP
100 110 120 130 140 150
280 290 300 310 320
pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
::. .:.: . :. :. :::: :: . .:... :. :..: :: .
XP_005 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD
160 170 180 190 200 210
330 340 350
pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
:
XP_005 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP
220 230 240 250 260 270
>>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa)
initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10
Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211)
100 110 120 130 140 150
pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH
:...::.:...:..: ::.::::::.::::
NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH
10 20 30
160 170 180 190 200 210
pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD
.:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .:
NP_009 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP
:: . : . : :.. :.. . . . . .:: .:: :: . . :
NP_009 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP
100 110 120 130 140 150
280 290 300 310 320
pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
::. .:.: . :. :. :::: :: . .:... :. :..: :: .
NP_009 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD
160 170 180 190 200 210
330 340 350
pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
:
NP_009 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP
220 230 240 250 260 270
>>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10
Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211)
100 110 120 130 140 150
pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH
:...::.:...:..: ::.::::::.::::
XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH
10 20 30
160 170 180 190 200 210
pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD
.:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .:
XP_016 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP
:: . : . : :.. :.. . . . . .:: .:: :: . . :
XP_016 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP
100 110 120 130 140 150
280 290 300 310 320
pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
::. .:.: . :. :. :::: :: . .:... :. :..: :: .
XP_016 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD
160 170 180 190 200 210
330 340 350
pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
:
XP_016 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP
220 230 240 250 260 270
>>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10
Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211)
100 110 120 130 140 150
pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH
:...::.:...:..: ::.::::::.::::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH
10 20 30
160 170 180 190 200 210
pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD
.:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .:
XP_005 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP
:: . : . : :.. :.. . . . . .:: .:: :: . . :
XP_005 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP
100 110 120 130 140 150
280 290 300 310 320
pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
::. .:.: . :. :. :::: :: . .:... :. :..: :: .
XP_005 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD
160 170 180 190 200 210
330 340 350
pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
:
XP_005 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP
220 230 240 250 260 270
>>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa)
initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10
Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211)
100 110 120 130 140 150
pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH
:...::.:...:..: ::.::::::.::::
XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH
10 20 30
160 170 180 190 200 210
pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD
.:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .:
XP_005 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP
:: . : . : :.. :.. . . . . .:: .:: :: . . :
XP_005 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP
100 110 120 130 140 150
280 290 300 310 320
pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE
::. .:.: . :. :. :::: :: . .:... :. :..: :: .
XP_005 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD
160 170 180 190 200 210
330 340 350
pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT
:
XP_005 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP
220 230 240 250 260 270
350 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:49:18 2016 done: Sat Nov 5 19:49:19 2016
Total Scan time: 10.320 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]