Result of FASTA (omim) for
pF1KB7589
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7589, 224 aa
1>>>pF1KB7589 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8241+/-0.000283; mu= 5.4506+/- 0.018
mean_var=189.7155+/-38.950, 0's: 0 Z-trim(124.3): 22 B-trim: 794 in 1/60
Lambda= 0.093116
statistics sampled from 45707 (45730) to 45707 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.536), width: 16
Scan time: 6.880
The best scores are: opt bits E(85289)
NP_061115 (OMIM: 610331) transcription cofactor HE ( 224) 1508 213.5 2.3e-55
NP_001136325 (OMIM: 610331) transcription cofactor ( 222) 1482 210.0 2.6e-54
NP_001269363 (OMIM: 610331) transcription cofactor ( 112) 452 71.4 7e-13
NP_005515 (OMIM: 139605) transcription factor HES- ( 280) 335 56.0 7.3e-08
NP_001135939 (OMIM: 608060) transcription factor H ( 247) 308 52.3 8.3e-07
NP_066993 (OMIM: 608060) transcription factor HES- ( 221) 305 51.9 1e-06
NP_061962 (OMIM: 609970) transcription factor HES- ( 173) 258 45.5 6.7e-05
NP_036390 (OMIM: 602953) hairy/enhancer-of-split r ( 304) 228 41.7 0.0017
XP_005244828 (OMIM: 608060) PREDICTED: transcripti ( 189) 208 38.8 0.0075
XP_016866118 (OMIM: 604674) PREDICTED: hairy/enhan ( 291) 210 39.2 0.0086
XP_016866117 (OMIM: 604674) PREDICTED: hairy/enhan ( 291) 210 39.2 0.0086
XP_016866116 (OMIM: 604674) PREDICTED: hairy/enhan ( 291) 210 39.2 0.0086
NP_036391 (OMIM: 604674) hairy/enhancer-of-split r ( 337) 210 39.3 0.0095
>>NP_061115 (OMIM: 610331) transcription cofactor HES-6 (224 aa)
initn: 1508 init1: 1508 opt: 1508 Z-score: 1115.0 bits: 213.5 E(85289): 2.3e-55
Smith-Waterman score: 1508; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)
10 20 30 40 50 60
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD
130 140 150 160 170 180
190 200 210 220
pF1KB7 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
::::::::::::::::::::::::::::::::::::::::::::
NP_061 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
190 200 210 220
>>NP_001136325 (OMIM: 610331) transcription cofactor HES (222 aa)
initn: 1126 init1: 1126 opt: 1482 Z-score: 1096.2 bits: 210.0 E(85289): 2.6e-54
Smith-Waterman score: 1482; 99.1% identity (99.1% similar) in 224 aa overlap (1-224:1-222)
10 20 30 40 50 60
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAE--AK
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDD
120 130 140 150 160 170
190 200 210 220
pF1KB7 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
180 190 200 210 220
>>NP_001269363 (OMIM: 610331) transcription cofactor HES (112 aa)
initn: 452 init1: 452 opt: 452 Z-score: 352.3 bits: 71.4 E(85289): 7e-13
Smith-Waterman score: 452; 100.0% identity (100.0% similar) in 70 aa overlap (1-70:1-70)
10 20 30 40 50 60
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT
::::::::::
NP_001 LENAEVLELTSASSCRRKRASASLPATSSACTRCTRSCPRARPSTLPSLPSS
70 80 90 100 110
>>NP_005515 (OMIM: 139605) transcription factor HES-1 [H (280 aa)
initn: 373 init1: 226 opt: 335 Z-score: 262.1 bits: 56.0 E(85289): 7.3e-08
Smith-Waterman score: 335; 34.3% identity (61.1% similar) in 198 aa overlap (26-211:35-229)
10 20 30 40 50
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA
::. ::..::.:::::::::..:. :. :
NP_005 IMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 -----EVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTF
..:::.:..::.::...... :.. . . . .. ::. .::.:: :
NP_005 LKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRF
70 80 90 100 110 120
120 130 140 150 160
pF1KB7 VSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWP--AGGAPG
.:::..... : ..::.:: . : .. .. :: .:: : : : : ::
NP_005 LSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPP
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB7 SP-IPSP----PGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRP
: .: : : :: :. .: :: . : ..::: :..
NP_005 PPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFG---GFQVVPAPDGQFAFLIPNGAFAHS
190 200 210 220 230 240
pF1KB7 W
NP_005 GPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN
250 260 270 280
>>NP_001135939 (OMIM: 608060) transcription factor HES-4 (247 aa)
initn: 325 init1: 152 opt: 308 Z-score: 243.2 bits: 52.3 E(85289): 8.3e-07
Smith-Waterman score: 308; 34.6% identity (60.6% similar) in 208 aa overlap (7-201:41-241)
10 20 30
pF1KB7 MAPPAAPG-RDRVGREDEDGWETRGDRKARKPLVEK
:: : .: .. : . : .. ::..::
NP_001 ASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB7 KRRARINESLQELRLLLAGA-----EVQAKLENAEVLELTVRRVQGVLRGRAREREQLQA
.::::::::: .:. :. : ..:::.:..::.:::.... :: :.. :.:
NP_001 RRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRS-LR-RVQVTAALSA
80 90 100 110 120
100 110 120 130 140
pF1KB7 EASE--RFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESM----PLREGSSFQDL
. . .. ::. .:. ::. :.. :... : : ..::.:: . : :. .:..
NP_001 DPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB7 LGDALAGPPRAPGRSGWPAGGAPGSPIPSPPG-PGDDLCSDLEEAPEAELSQAPAEGPDL
.: :: :. :.: :. .:: :: : : ::.: :.:. ::
NP_001 APAEAPAPEVYAGRPLLPSLGGP-FPLLAPPLLPG--LTRALPAAPRAG-PQGPG-GPWR
190 200 210 220 230 240
210 220
pF1KB7 VPAALGSLTTAQIARSVWRPW
NP_001 PWLR
>>NP_066993 (OMIM: 608060) transcription factor HES-4 is (221 aa)
initn: 338 init1: 152 opt: 305 Z-score: 241.7 bits: 51.9 E(85289): 1e-06
Smith-Waterman score: 305; 34.0% identity (59.4% similar) in 212 aa overlap (2-201:11-215)
10 20 30 40 50
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLL
: : : . ..: . . ::. ::..::.::::::::: .:. :
NP_066 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTL
10 20 30 40 50 60
60 70 80 90 100
pF1KB7 LAGA-----EVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASE--RFAAGYIQCM
. : ..:::.:..::.:::.... :: :.. :.:. . .. ::. .:.
NP_066 ILDALRKESSRHSKLEKADILEMTVRHLRS-LR-RVQVTAALSADPAVLGKYRAGFHECL
70 80 90 100 110
110 120 130 140 150 160
pF1KB7 HEVHTFVSTCQAIDATVAAELLNHLLESM----PLREGSSFQDLLGDALAGPPRAPGRSG
::. :.. :... : : ..::.:: . : :. .:.. .: ::
NP_066 AEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEAPAPEVYAGRPL
120 130 140 150 160 170
170 180 190 200 210
pF1KB7 WPAGGAPGSPIPSPPG-PGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARS
:. :.: :. .:: :: : : ::.: :.:. ::
NP_066 LPSLGGP-FPLLAPPLLPG--LTRALPAAPRAG-PQGPG-GPWRPWLR
180 190 200 210 220
220
pF1KB7 VWRPW
>>NP_061962 (OMIM: 609970) transcription factor HES-2 [H (173 aa)
initn: 261 init1: 112 opt: 258 Z-score: 208.9 bits: 45.5 E(85289): 6.7e-05
Smith-Waterman score: 258; 36.6% identity (62.1% similar) in 161 aa overlap (26-178:14-168)
10 20 30 40 50
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLL---LAGAEV
::. :::.::.::::::.::..:. : : : :
NP_061 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGREN
10 20 30 40
60 70 80 90 100 110
pF1KB7 Q--AKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQ
. .:::.:.:::.::: .: . . : .. . :: :. .. . .:.
NP_061 SNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDS---YREGYSACVARLARVLPACR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 AIDATVAAELLNHLLE--SMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPS
... .:.:.::.:: . . .:. : : . .: ::. . ::.. :: ::
NP_061 VLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAP--APASAPEPASAPVPSP-PS
110 120 130 140 150 160
180 190 200 210 220
pF1KB7 PP-GPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
:: :::
NP_061 PPCGPGLWRPW
170
>>NP_036390 (OMIM: 602953) hairy/enhancer-of-split relat (304 aa)
initn: 239 init1: 106 opt: 228 Z-score: 184.0 bits: 41.7 E(85289): 0.0017
Smith-Waterman score: 228; 32.7% identity (58.2% similar) in 196 aa overlap (26-211:50-237)
10 20 30 40 50
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA
:: :. ..::.:: :::.::.::: :. .:
NP_036 EVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSA
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB7 -EVQ--AKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVS
: : ::::.::.:..:: ... . . .. . .: : . . :. .:. :: ..:
NP_036 FEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLS
80 90 100 110 120 130
120 130 140 150 160
pF1KB7 TCQAIDAT--VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAP--G
...::. . ..:..:: . ::..: : :: . : : : : .
NP_036 IIEGLDASDPLRVRLVSHLNNYASQREAAS------GAHAGLGHIPW--GTVFGHHPHIA
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB7 SPIPSPP-GPGD--DLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
:. : : :. : : ...:..: :.: : :::
NP_036 HPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLS
200 210 220 230 240 250
NP_036 PPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF
260 270 280 290 300
>>XP_005244828 (OMIM: 608060) PREDICTED: transcription f (189 aa)
initn: 244 init1: 152 opt: 208 Z-score: 172.1 bits: 38.8 E(85289): 0.0075
Smith-Waterman score: 208; 33.1% identity (60.9% similar) in 151 aa overlap (58-201:40-183)
30 40 50 60 70 80
pF1KB7 ARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQ
..:::.:..::.:::.... :: :..
XP_005 SASPMAGAPASASRTPDKPRSAAEHRKSSRHSKLEKADILEMTVRHLRS-LR-RVQVTAA
10 20 30 40 50 60
90 100 110 120 130 140
pF1KB7 LQAEASE--RFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESM----PLREGSSF
:.:. . .. ::. .:. ::. :.. :... : : ..::.:: . : :. .:.
XP_005 LSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASL
70 80 90 100 110 120
150 160 170 180 190 200
pF1KB7 QDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPG-PGDDLCSDLEEAPEAELSQAPAEG
. .: :: :. :.: :. .:: :: : : ::.: :.:. :
XP_005 SPAAPAEAPAPEVYAGRPLLPSLGGP-FPLLAPPLLPG--LTRALPAAPRAG-PQGPG-G
130 140 150 160 170 180
210 220
pF1KB7 PDLVPAALGSLTTAQIARSVWRPW
:
XP_005 PWRPWLR
>>XP_016866118 (OMIM: 604674) PREDICTED: hairy/enhancer- (291 aa)
initn: 215 init1: 105 opt: 210 Z-score: 171.1 bits: 39.2 E(85289): 0.0086
Smith-Waterman score: 210; 28.6% identity (60.2% similar) in 196 aa overlap (26-214:3-191)
10 20 30 40 50
pF1KB7 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA-EVQ-
:: :. ..::.:: :::.::.::: :. : : :
XP_016 MARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQG
10 20 30
60 70 80 90 100 110
pF1KB7 -AKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAI
::::.::.:..:: ... . .. . .: : . .. :. .:. :: ..:. ...
XP_016 SAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGL
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB7 DAT--VAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAG--GAPGSPIPS
:.. . ..:..:: ::.... . . : : : . : :. :.. . .
XP_016 DSSDPLRVRLVSHLSTCATQREAAAMTSSM--AHHHHPLHPHH--WAAAFHHLPAA-LLQ
100 110 120 130 140 150
180 190 200 210 220
pF1KB7 PPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
: : . . . . .:. ::.: :. :... .:
XP_016 PNGLHASESTPCRLSTTSEVP--PAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTS
160 170 180 190 200 210
XP_016 LLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQ
220 230 240 250 260 270
224 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 08:53:54 2016 done: Fri Nov 4 08:53:55 2016
Total Scan time: 6.880 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]