Result of FASTA (omim) for
pF1KB7274
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7274, 745 aa
1>>>pF1KB7274 745 - 745 aa - 745 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6527+/-0.000442; mu= -10.9029+/- 0.028
mean_var=271.0086+/-57.820, 0's: 0 Z-trim(118.2): 24 B-trim: 565 in 1/57
Lambda= 0.077908
statistics sampled from 30899 (30923) to 30899 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.363), width: 16
Scan time: 8.210
The best scores are: opt bits E(85289)
NP_116021 (OMIM: 605553) poly(A) polymerase alpha ( 745) 4839 557.8 5.6e-158
NP_001280556 (OMIM: 605553) poly(A) polymerase alp ( 744) 4820 555.7 2.5e-157
XP_005267339 (OMIM: 605553) PREDICTED: poly(A) pol ( 699) 4381 506.3 1.7e-142
XP_005267338 (OMIM: 605553) PREDICTED: poly(A) pol ( 724) 4376 505.8 2.5e-142
XP_016876425 (OMIM: 605553) PREDICTED: poly(A) pol ( 698) 4362 504.2 7.3e-142
XP_016876424 (OMIM: 605553) PREDICTED: poly(A) pol ( 723) 4357 503.7 1.1e-141
NP_064529 (OMIM: 607436) poly(A) polymerase beta [ ( 637) 3527 410.3 1.2e-113
NP_001280561 (OMIM: 605553) poly(A) polymerase alp ( 495) 3187 372.1 3.1e-102
NP_001280557 (OMIM: 605553) poly(A) polymerase alp ( 495) 3187 372.1 3.1e-102
NP_075045 (OMIM: 616865) poly(A) polymerase gamma ( 736) 2817 330.6 1.4e-89
XP_005264557 (OMIM: 616865) PREDICTED: poly(A) pol ( 714) 2768 325.1 6.4e-88
XP_005264558 (OMIM: 616865) PREDICTED: poly(A) pol ( 692) 2668 313.8 1.5e-84
NP_001238935 (OMIM: 605553) poly(A) polymerase alp ( 285) 1847 221.4 4e-57
XP_011531343 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 1623 196.3 2.5e-49
XP_016860212 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 1623 196.3 2.5e-49
XP_016860213 (OMIM: 616865) PREDICTED: poly(A) pol ( 476) 1574 190.8 1.1e-47
NP_001238936 (OMIM: 605553) poly(A) polymerase alp ( 238) 1343 164.7 3.9e-40
>>NP_116021 (OMIM: 605553) poly(A) polymerase alpha isof (745 aa)
initn: 4839 init1: 4839 opt: 4839 Z-score: 2957.2 bits: 557.8 E(85289): 5.6e-158
Smith-Waterman score: 4839; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:1-745)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
670 680 690 700 710 720
730 740
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::
NP_116 LSDIPALPANPIPVIKNSIKLRLNR
730 740
>>NP_001280556 (OMIM: 605553) poly(A) polymerase alpha i (744 aa)
initn: 3683 init1: 3683 opt: 4820 Z-score: 2945.6 bits: 555.7 E(85289): 2.5e-157
Smith-Waterman score: 4820; 99.9% identity (99.9% similar) in 745 aa overlap (1-745:1-744)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATKTSPLNSSGSSQG-NSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
550 560 570 580 590
610 620 630 640 650 660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
660 670 680 690 700 710
730 740
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::
NP_001 LSDIPALPANPIPVIKNSIKLRLNR
720 730 740
>>XP_005267339 (OMIM: 605553) PREDICTED: poly(A) polymer (699 aa)
initn: 4441 init1: 4381 opt: 4381 Z-score: 2679.4 bits: 506.3 E(85289): 1.7e-142
Smith-Waterman score: 4461; 93.8% identity (93.8% similar) in 745 aa overlap (1-745:1-699)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
:::::::: ::::::
XP_005 PKKTKTEE----------------------------------------------KTSSTD
670
730 740
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::
XP_005 LSDIPALPANPIPVIKNSIKLRLNR
680 690
>>XP_005267338 (OMIM: 605553) PREDICTED: poly(A) polymer (724 aa)
initn: 4374 init1: 4374 opt: 4376 Z-score: 2676.1 bits: 505.8 E(85289): 2.5e-142
Smith-Waterman score: 4650; 97.2% identity (97.2% similar) in 745 aa overlap (1-745:1-724)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
:::::::: :::::::::::::::::::::::::::::::
XP_005 PKKTKTEE---------------------EQLDTETSTTQSETIQTAASLLASQKTSSTD
670 680 690
730 740
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::
XP_005 LSDIPALPANPIPVIKNSIKLRLNR
700 710 720
>>XP_016876425 (OMIM: 605553) PREDICTED: poly(A) polymer (698 aa)
initn: 3690 init1: 3690 opt: 4362 Z-score: 2667.9 bits: 504.2 E(85289): 7.3e-142
Smith-Waterman score: 4442; 93.7% identity (93.7% similar) in 745 aa overlap (1-745:1-698)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATKTSPLNSSGSSQG-NSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
550 560 570 580 590
610 620 630 640 650 660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
:::::::: ::::::
XP_016 PKKTKTEE----------------------------------------------KTSSTD
660 670
730 740
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::
XP_016 LSDIPALPANPIPVIKNSIKLRLNR
680 690
>>XP_016876424 (OMIM: 605553) PREDICTED: poly(A) polymer (723 aa)
initn: 3692 init1: 3692 opt: 4357 Z-score: 2664.6 bits: 503.7 E(85289): 1.1e-141
Smith-Waterman score: 4631; 97.0% identity (97.0% similar) in 745 aa overlap (1-745:1-723)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATKTSPLNSSGSSQG-NSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
550 560 570 580 590
610 620 630 640 650 660
pF1KB7 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB7 PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
:::::::: :::::::::::::::::::::::::::::::
XP_016 PKKTKTEE---------------------EQLDTETSTTQSETIQTAASLLASQKTSSTD
660 670 680 690
730 740
pF1KB7 LSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::
XP_016 LSDIPALPANPIPVIKNSIKLRLNR
700 710 720
>>NP_064529 (OMIM: 607436) poly(A) polymerase beta [Homo (637 aa)
initn: 3533 init1: 3253 opt: 3527 Z-score: 2161.3 bits: 410.3 E(85289): 1.2e-113
Smith-Waterman score: 3527; 86.1% identity (93.6% similar) in 625 aa overlap (1-625:2-624)
10 20 30 40 50
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQ
::::::::: : :: ..::..::::::.::::::.:::.:::::.::::::::::::
NP_064 MMPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 RRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCV
::::.: :::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_064 RRILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 APRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIP
:: :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_064 APSHVDRSDFFTSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 EDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSN
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_064 EDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSN
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 ILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPV
::::::::::::::::::::::::.:::::.:::::::.::::::::::.::: ::::::
NP_064 ILGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB7 WDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWS
:::::::::::::::::::::::::::::::.::::::.:::::::::: ::::::::::
NP_064 WDPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB7 KLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQ
::::::.::::::::::::::: ::::.::::::::::::::::::::::::::::::::
NP_064 KLFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB7 SFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEV
:::::::::: ::::::::::: .:: .::: ::.:::::::::::::::::.::::::.
NP_064 SFPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEM
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB7 DMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPT
:::.:::..::.::::::.:::: :: ::::: .:: :::::.::: .::::::: :
NP_064 GMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDLSAGCENSMSVPSST
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB7 SATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTA
:. ::.:: :: :::::::: :: .:::.:::::: :. :::..:::: . .::::...
NP_064 STMKTGPLISS--SQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAV
550 560 570 580 590
600 610 620 630 640 650
pF1KB7 TQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEE
.:::::: :: :.:::::: :.. :
NP_064 SQPAISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL
600 610 620 630
>>NP_001280561 (OMIM: 605553) poly(A) polymerase alpha i (495 aa)
initn: 3187 init1: 3187 opt: 3187 Z-score: 1956.5 bits: 372.1 E(85289): 3.1e-102
Smith-Waterman score: 3187; 100.0% identity (100.0% similar) in 495 aa overlap (251-745:1-495)
230 240 250 260 270 280
pF1KB7 RLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWE
::::::::::::::::::::::::::::::
NP_001 MLVARTCQLYPNAIASTLVHKFFLVFSKWE
10 20 30
290 300 310 320 330 340
pF1KB7 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
40 50 60 70 80 90
350 360 370 380 390 400
pF1KB7 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
100 110 120 130 140 150
410 420 430 440 450 460
pF1KB7 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
160 170 180 190 200 210
470 480 490 500 510 520
pF1KB7 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
220 230 240 250 260 270
530 540 550 560 570 580
pF1KB7 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
280 290 300 310 320 330
590 600 610 620 630 640
pF1KB7 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
340 350 360 370 380 390
650 660 670 680 690 700
pF1KB7 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
400 410 420 430 440 450
710 720 730 740
pF1KB7 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
460 470 480 490
>>NP_001280557 (OMIM: 605553) poly(A) polymerase alpha i (495 aa)
initn: 3187 init1: 3187 opt: 3187 Z-score: 1956.5 bits: 372.1 E(85289): 3.1e-102
Smith-Waterman score: 3187; 100.0% identity (100.0% similar) in 495 aa overlap (251-745:1-495)
230 240 250 260 270 280
pF1KB7 RLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWE
::::::::::::::::::::::::::::::
NP_001 MLVARTCQLYPNAIASTLVHKFFLVFSKWE
10 20 30
290 300 310 320 330 340
pF1KB7 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEE
40 50 60 70 80 90
350 360 370 380 390 400
pF1KB7 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRI
100 110 120 130 140 150
410 420 430 440 450 460
pF1KB7 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDI
160 170 180 190 200 210
470 480 490 500 510 520
pF1KB7 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALND
220 230 240 250 260 270
530 540 550 560 570 580
pF1KB7 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQ
280 290 300 310 320 330
590 600 610 620 630 640
pF1KB7 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAAT
340 350 360 370 380 390
650 660 670 680 690 700
pF1KB7 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQ
400 410 420 430 440 450
710 720 730 740
pF1KB7 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 SETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
460 470 480 490
>>NP_075045 (OMIM: 616865) poly(A) polymerase gamma [Hom (736 aa)
initn: 2784 init1: 2669 opt: 2817 Z-score: 1729.0 bits: 330.6 E(85289): 1.4e-89
Smith-Waterman score: 2844; 61.2% identity (78.8% similar) in 747 aa overlap (13-745:12-736)
10 20 30 40 50 60
pF1KB7 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
.: :::::::::::::.::: : . :::::...:::::::.::::..
NP_075 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
:...:::::::::::: ..::::::: ::. .::::::::::::::::::::::::::::
NP_075 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: .
NP_075 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB7 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
.::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::.
NP_075 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB7 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
::::::::::::::::::::::: :::::::::::::::::::::::::::: :::::::
NP_075 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB7 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..:::
NP_075 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB7 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
:.: :::::::.::::: ::: ::...::::::::::::.:::.::.:::::::::::::
NP_075 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB7 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:..
NP_075 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG
420 430 440 450 460 470
490 500 510 520 530
pF1KB7 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN
::: : :::.::::. :: ..::::::.: : : .:..: :: : :.::
NP_075 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN
480 490 500 510 520 530
540 550 560 570 580
pF1KB7 SMSVPSPTSATKTSPLNSSGSSQGRNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGG
. ::.: . :: : : .. ::: :: ... .. : .:.: . :
NP_075 GTPFNSPASKSD-SP--SVGETE-RNSAEPAAVIVEKPLSVPPAQGLSIPVI-------G
540 550 560 570 580
590 600 610 620 630 640
pF1KB7 TSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVG
.. .: .:.. :.. : .:.: : :...: ..:. .: . :: ::
NP_075 AKVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP---
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB7 VKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAA
::. :: . .::. : : : . .: :.:. ... .:.. .
NP_075 -KRSHSPSIDGTPKRLKDVEKFIR-----LESTFKDPRTAEERKRKSVDAIGGESMPIPT
650 660 670 680 690
710 720 730 740
pF1KB7 SLLASQKT-SSTDLSDIPA-LPANPIPVIKNSIKLRLNR
. .: : .: : . .::: : ::::::.: :::
NP_075 IDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
700 710 720 730
745 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:12:56 2016 done: Sat Nov 5 22:12:57 2016
Total Scan time: 8.210 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]