Result of FASTA (omim) for
pF1KB7256
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7256, 441 aa
1>>>pF1KB7256 441 - 441 aa - 441 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1167+/-0.000445; mu= 18.4251+/- 0.028
mean_var=66.1532+/-13.016, 0's: 0 Z-trim(110.0): 166 B-trim: 33 in 1/53
Lambda= 0.157688
statistics sampled from 18151 (18323) to 18151 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.215), width: 16
Scan time: 8.120
The best scores are: opt bits E(85289)
NP_006019 (OMIM: 604654) 5-hydroxytryptamine recep ( 441) 2934 676.8 3e-194
XP_011541365 (OMIM: 604654) PREDICTED: 5-hydroxytr ( 430) 2823 651.6 1.2e-186
XP_016874041 (OMIM: 604654) PREDICTED: 5-hydroxytr ( 372) 2463 569.6 4.7e-162
NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 484) 1135 267.6 5.2e-71
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 1132 266.9 8e-71
NP_998786 (OMIM: 182139) 5-hydroxytryptamine recep ( 516) 1039 245.8 2e-64
NP_001243542 (OMIM: 610123) 5-hydroxytryptamine re ( 456) 709 170.6 7.3e-42
NP_872395 (OMIM: 610123) 5-hydroxytryptamine recep ( 471) 709 170.7 7.5e-42
NP_570126 (OMIM: 610121) 5-hydroxytryptamine recep ( 447) 708 170.4 8.4e-42
NP_938055 (OMIM: 610123) 5-hydroxytryptamine recep ( 441) 627 152.0 2.9e-36
NP_938056 (OMIM: 610123) 5-hydroxytryptamine recep ( 456) 627 152.0 3e-36
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 620 150.4 9.3e-36
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 605 147.0 9.7e-35
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 584 142.2 2.9e-33
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 581 141.6 4.8e-33
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 571 139.3 2.7e-32
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 566 138.2 5.1e-32
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 566 138.2 5.1e-32
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 566 138.2 5.1e-32
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 564 137.7 6.7e-32
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 540 132.2 2.7e-30
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 540 132.2 2.8e-30
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 540 132.2 2.8e-30
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 540 132.2 2.9e-30
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 540 132.2 2.9e-30
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 540 132.2 2.9e-30
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 538 131.8 3.8e-30
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 538 131.8 3.8e-30
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 537 131.5 4.8e-30
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 523 128.3 3.5e-29
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 524 128.6 3.6e-29
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 524 128.6 3.7e-29
NP_001243543 (OMIM: 610123) 5-hydroxytryptamine re ( 482) 522 128.1 4.9e-29
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 509 125.2 3.8e-28
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 509 125.2 4e-28
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 497 122.4 2.5e-27
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 492 121.3 5.3e-27
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 481 118.8 2.8e-26
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 481 118.8 2.8e-26
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 470 116.3 1.7e-25
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 463 114.7 5.2e-25
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 462 114.5 6.1e-25
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 457 113.4 1.5e-24
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 437 108.8 3.2e-23
XP_005254199 (OMIM: 118505,612052) PREDICTED: neur ( 243) 390 97.9 3.1e-20
XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245) 390 97.9 3.1e-20
NP_000071 (OMIM: 100725,605809,608931,616324) acet ( 493) 381 96.0 2.3e-19
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 379 95.6 3e-19
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 379 95.6 3.1e-19
NP_005190 (OMIM: 100730,253290,265000) acetylcholi ( 517) 379 95.6 3.2e-19
>>NP_006019 (OMIM: 604654) 5-hydroxytryptamine receptor (441 aa)
initn: 2934 init1: 2934 opt: 2934 Z-score: 3608.4 bits: 676.8 E(85289): 3e-194
Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 441 aa overlap (1-441:1-441)
10 20 30 40 50 60
pF1KB7 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
370 380 390 400 410 420
430 440
pF1KB7 LFMLGIYTITLCSLWALWGGV
:::::::::::::::::::::
NP_006 LFMLGIYTITLCSLWALWGGV
430 440
>>XP_011541365 (OMIM: 604654) PREDICTED: 5-hydroxytrypta (430 aa)
initn: 2822 init1: 2822 opt: 2823 Z-score: 3472.0 bits: 651.6 E(85289): 1.2e-186
Smith-Waterman score: 2823; 99.1% identity (99.3% similar) in 429 aa overlap (13-441:2-430)
10 20 30 40 50 60
pF1KB7 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
:. :::::::::::::::::::::::::::::::::::::::::::
XP_011 MIVYFPGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
10 20 30 40
70 80 90 100 110 120
pF1KB7 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB7 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB7 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB7 VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB7 LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB7 VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
350 360 370 380 390 400
430 440
pF1KB7 LFMLGIYTITLCSLWALWGGV
:::::::::::::::::::::
XP_011 LFMLGIYTITLCSLWALWGGV
410 420 430
>>XP_016874041 (OMIM: 604654) PREDICTED: 5-hydroxytrypta (372 aa)
initn: 2463 init1: 2463 opt: 2463 Z-score: 3030.3 bits: 569.6 E(85289): 4.7e-162
Smith-Waterman score: 2463; 99.7% identity (100.0% similar) in 371 aa overlap (71-441:2-372)
50 60 70 80 90 100
pF1KB7 QKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMF
.:::::::::::::::::::::::::::::
XP_016 MMDAENQILKTSVWYQEVWNDEFLSWNSSMF
10 20 30
110 120 130 140 150 160
pF1KB7 DEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETY
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB7 AFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB7 SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVG
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB7 YTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFL
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB7 CLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQ
280 290 300 310 320 330
410 420 430 440
pF1KB7 QEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
:::::::::::::::::::::::::::::::::::::::::
XP_016 QEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
340 350 360 370
>>NP_000860 (OMIM: 182139) 5-hydroxytryptamine receptor (484 aa)
initn: 1293 init1: 758 opt: 1135 Z-score: 1395.9 bits: 267.6 E(85289): 5.2e-71
Smith-Waterman score: 1245; 42.2% identity (70.7% similar) in 464 aa overlap (14-438:23-481)
10 20 30 40 50
pF1KB7 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVY
:.: : : ... :: .:: :: .:.: ::::
NP_000 MLGKLAMLLWVQQALLALLLPTLLAQG-EARRSRNTTRPALLRLSDYLLTNYRKGVRPVR
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 NWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLS
.: : ::: .:..:.:::.:: .::.: : .::.. :.::::.:: ::.: ..:.: .
NP_000 DWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSL
.::.:::.::::::. . :..::::. .: ..::::.:::.::::. : ::::::::::
NP_000 SIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 TFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ-SSAGGFAQIQ
:: : :::..:..... : :: .. :...:.:..:::::.: . .. :.. .:...
NP_000 TFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 FNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSN
: ::.::.:: ::::::.::::::..:. .:::::: :. :: ..:.::.:: . .:.
NP_000 FYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD
240 250 260 270 280 290
300 310 320 330
pF1KB7 QVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP------------
.: .. .::::: .:..:::.::.:::..: .:...: .: : :
NP_000 TLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVH-KQDLQQPVPAWLRHLVLERIA
300 310 320 330 340 350
340 350 360 370 380
pF1KB7 -FLCLRGDTDADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE----------------
.:::: .. ..:: : ...:. :.. : .:.: .. : ..
NP_000 WLLCLREQSTSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPR
360 370 380 390 400 410
390 400 410 420 430
pF1KB7 --------VWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLC
. ..:.:: ..:. .:. . .:: . : .:.:::. ::. . :.:::
NP_000 EASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLV
420 430 440 450 460 470
440
pF1KB7 SLWALWGGV
::..:
NP_000 MLWSIWQYA
480
>>NP_001155244 (OMIM: 182139) 5-hydroxytryptamine recept (463 aa)
initn: 1293 init1: 758 opt: 1132 Z-score: 1392.5 bits: 266.9 E(85289): 8e-71
Smith-Waterman score: 1242; 43.0% identity (71.6% similar) in 447 aa overlap (31-438:18-460)
10 20 30 40 50 60
pF1KB7 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
:: .:: :: .:.: :::: .: : :::
NP_001 MHRSFLQARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVS
10 20 30 40
70 80 90 100 110 120
pF1KB7 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
.:..:.:::.:: .::.: : .::.. :.::::.:: ::.: ..:.: ..::.:::.:
NP_001 IDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB7 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
:::::. . :..::::. .: ..::::.:::.::::. : :::::::::::: : :::.
NP_001 NEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTI
110 120 130 140 150 160
190 200 210 220 230
pF1KB7 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ-SSAGGFAQIQFNVVMRRHP
.:..... : :: .. :...:.:..:::::.: . .. :.. .:...: ::.::.:
NP_001 QDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB7 LVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGST
: ::::::.::::::..:. .:::::: :. :: ..:.::.:: . .:. .: .. .:
NP_001 LFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGT
230 240 250 260 270 280
300 310 320 330 340
pF1KB7 PLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP-------------FLCLRGDT
:::: .:..:::.::.:::..: .:...: .: : : .:::: ..
NP_001 PLIGVYFVVCMALLVISLAETIFIVRLVH-KQDLQQPVPAWLRHLVLERIAWLLCLREQS
290 300 310 320 330 340
350 360 370 380
pF1KB7 DADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE------------------------V
..:: : ...:. :.. : .:.: .. : .. .
NP_001 TSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGL
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB7 WSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
..:.:: ..:. .:. . .:: . : .:.:::. ::. . :.::: ::..:
NP_001 LQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
410 420 430 440 450 460
>>NP_998786 (OMIM: 182139) 5-hydroxytryptamine receptor (516 aa)
initn: 1267 init1: 758 opt: 1039 Z-score: 1277.5 bits: 245.8 E(85289): 2e-64
Smith-Waterman score: 1091; 42.7% identity (69.8% similar) in 410 aa overlap (14-376:23-427)
10 20 30 40 50
pF1KB7 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVY
:.: : : ... :: .:: :: .:.: ::::
NP_998 MLGKLAMLLWVQQALLALLLPTLLAQG-EARRSRNTTRPALLRLSDYLLTNYRKGVRPVR
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 NWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLS
.: : ::: .:..:.:::.:: .::.: : .::.. :.::::.:: ::.: ..:.: .
NP_998 DWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSL
.::.:::.::::::. . :..::::. .: ..::::.:::.::::. : ::::::::::
NP_998 SIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 TFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ-SSAGGFAQIQ
:: : :::..:..... : :: .. :...:.:..:::::.: . .. :.. .:...
NP_998 TFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 FNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSN
: ::.::.:: ::::::.::::::..:. .:::::: :. :: ..:.::.:: . .:.
NP_998 FYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD
240 250 260 270 280 290
300 310
pF1KB7 QVPRSVGSTPLIGH--------------------------------FFTICMAFLVLSLA
.: .. .:::::. .:..:::.::.:::
NP_998 TLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLA
300 310 320 330 340 350
320 330 340 350 360
pF1KB7 KSIVLVKFLHDEQRGGQEQP-------------FLCLRGDTDADRPRVEPRAQRAVVTES
..: .:...: .: : : .:::: .. ..:: : ...:. :..
NP_998 ETIFIVRLVH-KQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP---PATSQATKTDD
360 370 380 390 400 410
370 380 390 400 410 420
pF1KB7 -SLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFML
: .:.: .. :
NP_998 CSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIRE
420 430 440 450 460 470
>>NP_001243542 (OMIM: 610123) 5-hydroxytryptamine recept (456 aa)
initn: 765 init1: 382 opt: 709 Z-score: 872.5 bits: 170.6 E(85289): 7.3e-42
Smith-Waterman score: 747; 33.3% identity (63.0% similar) in 405 aa overlap (45-435:52-454)
20 30 40 50 60 70
pF1KB7 VAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAE
: ::: : . : : ... . :::::. .
NP_001 QGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQ
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB7 NQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY
..:.. .: . ::.. :.::: . : ..:. . .: :::.: :..:... :
NP_001 LHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB7 VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDI
.::.. : :. ::..: : :.:. . :::: :::.:::.:.:.::... : . . .:
NP_001 AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEI
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB7 QHDKKAFLND-SEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFL
.. .:. .:::::..:.. . :. ... . :: : :..::.: .::..::.:: ::
NP_001 TDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFL
210 220 230 240 250 260
260 270 280 290 300 310
pF1KB7 MLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFL
. .: ::::: . :. :: ..:.::.:: . ::. .: : .::::: .:..:....
NP_001 VAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLM
270 280 290 300 310
320 330 340 350 360 370
pF1KB7 VLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRP-RVEPRAQRAVVTESSLYGEHL
: :: ..: ....:: : . : : : : . .: ::
NP_001 VGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHL
320 330 340 350 360 370
380 390 400 410 420
pF1KB7 A---QP----GTLK-EVWSQLQSISNYLQTQDQTDQQEAE----WLVLLSRFDRLLFQSY
.: : . . ..: . :.. ..: . . :. . :: . .: .::. :
NP_001 PGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLY
380 390 400 410 420 430
430 440
pF1KB7 LFMLGIYTITLCSLWALWGGV
:.... ::. ::
NP_001 LLFMASSIITVICLWNT
440 450
>>NP_872395 (OMIM: 610123) 5-hydroxytryptamine receptor (471 aa)
initn: 765 init1: 382 opt: 709 Z-score: 872.3 bits: 170.7 E(85289): 7.5e-42
Smith-Waterman score: 747; 33.3% identity (63.0% similar) in 405 aa overlap (45-435:67-469)
20 30 40 50 60 70
pF1KB7 VAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAE
: ::: : . : : ... . :::::. .
NP_872 TGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQ
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB7 NQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY
..:.. .: . ::.. :.::: . : ..:. . .: :::.: :..:... :
NP_872 LHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB7 VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDI
.::.. : :. ::..: : :.:. . :::: :::.:::.:.:.::... : . . .:
NP_872 AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEI
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB7 QHDKKAFLND-SEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFL
.. .:. .:::::..:.. . :. ... . :: : :..::.: .::..::.:: ::
NP_872 TDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFL
220 230 240 250 260 270
260 270 280 290 300 310
pF1KB7 MLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFL
. .: ::::: . :. :: ..:.::.:: . ::. .: : .::::: .:..:....
NP_872 VAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLM
280 290 300 310 320 330
320 330 340 350 360 370
pF1KB7 VLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRP-RVEPRAQRAVVTESSLYGEHL
: :: ..: ....:: : . : : : : . .: ::
NP_872 VGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHL
340 350 360 370 380 390
380 390 400 410 420
pF1KB7 A---QP----GTLK-EVWSQLQSISNYLQTQDQTDQQEAE----WLVLLSRFDRLLFQSY
.: : . . ..: . :.. ..: . . :. . :: . .: .::. :
NP_872 PGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLY
400 410 420 430 440 450
430 440
pF1KB7 LFMLGIYTITLCSLWALWGGV
:.... ::. ::
NP_872 LLFMASSIITVICLWNT
460 470
>>NP_570126 (OMIM: 610121) 5-hydroxytryptamine receptor (447 aa)
initn: 721 init1: 366 opt: 708 Z-score: 871.4 bits: 170.4 E(85289): 8.4e-42
Smith-Waterman score: 708; 31.5% identity (63.5% similar) in 397 aa overlap (45-435:52-445)
20 30 40 50 60 70
pF1KB7 VAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAE
: :: :.. : : ... . ::: :::.
NP_570 QGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQ
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB7 NQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY
:.: . .:.. ::.. :..:: . : .... .: :::.: : .:... :.
NP_570 LQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLT
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB7 VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDI
.:..: : :. ::..:.: :.:. . :::: :::..::.:.:.::... :.. . .:
NP_570 AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEI
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB7 QH-DKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFL
..:.. ...:::::..... .. . . . ::.: :..::.: .:...::.:: ::
NP_570 TDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFL
210 220 230 240 250 260
260 270 280 290 300 310
pF1KB7 MLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFL
. .: ::::: . . : :: ..:.::.:: . :.. .: : .::::. .:..:....
NP_570 VAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLM
270 280 290 300 310
320 330 340 350 360 370
pF1KB7 VLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRP-RVEPRAQRAVVTESSLYGEHL
:.:: ... .. .:: .: : : : : . .: ::
NP_570 VVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHL
320 330 340 350 360 370
380 390 400 410 420
pF1KB7 A---QPGTLK-EVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYT
.:: : . . .. . . .:. .: :. . .: :::. ::....
NP_570 PGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMEL-WVQFSHAMDTLLFRLYLLFMASSI
380 390 400 410 420 430
430 440
pF1KB7 ITLCSLWALWGGV
.:. ::
NP_570 LTVIVLWNT
440
>>NP_938055 (OMIM: 610123) 5-hydroxytryptamine receptor (441 aa)
initn: 730 init1: 300 opt: 627 Z-score: 771.9 bits: 152.0 E(85289): 2.9e-36
Smith-Waterman score: 686; 32.8% identity (60.5% similar) in 405 aa overlap (45-435:52-439)
20 30 40 50 60 70
pF1KB7 VAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAE
: ::: : . : : ... . :::::
NP_938 QGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDV---
30 40 50 60 70
80 90 100 110 120 130
pF1KB7 NQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY
::.. :.::: . : ..:. . .: :::.: :..:... :
NP_938 ------------VWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT
80 90 100 110 120
140 150 160 170 180 190
pF1KB7 VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDI
.::.. : :. ::..: : :.:. . :::: :::.:::.:.:.::... : . . .:
NP_938 AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEI
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB7 QHDKKAFLND-SEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFL
.. .:. .:::::..:.. . :. ... . :: : :..::.: .::..::.:: ::
NP_938 TDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFL
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB7 MLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFL
. .: ::::: . :. :: ..:.::.:: . ::. .: : .::::: .:..:....
NP_938 VAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLM
250 260 270 280 290 300
320 330 340 350 360 370
pF1KB7 VLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRP-RVEPRAQRAVVTESSLYGEHL
: :: ..: ....:: : . : : : : . .: ::
NP_938 VGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHL
310 320 330 340 350 360
380 390 400 410 420
pF1KB7 A---QP----GTLK-EVWSQLQSISNYLQTQDQTDQQEAE----WLVLLSRFDRLLFQSY
.: : . . ..: . :.. ..: . . :. . :: . .: .::. :
NP_938 PGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLY
370 380 390 400 410 420
430 440
pF1KB7 LFMLGIYTITLCSLWALWGGV
:.... ::. ::
NP_938 LLFMASSIITVICLWNT
430 440
441 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:22:59 2016 done: Fri Nov 4 06:23:01 2016
Total Scan time: 8.120 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]