Result of FASTA (omim) for
pF1KB7246
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7246, 520 aa
1>>>pF1KB7246 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4697+/-0.00046; mu= -6.3579+/- 0.028
mean_var=324.3250+/-64.540, 0's: 0 Z-trim(118.9): 138 B-trim: 67 in 1/54
Lambda= 0.071217
statistics sampled from 32160 (32307) to 32160 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.379), width: 16
Scan time: 9.620
The best scores are: opt bits E(85289)
NP_775487 (OMIM: 611159) keratin, type II cytoskel ( 520) 3364 359.8 1.1e-98
NP_001287743 (OMIM: 611159) keratin, type II cytos ( 410) 2494 270.4 7.5e-72
XP_011536312 (OMIM: 611159) PREDICTED: keratin, ty ( 488) 1728 191.7 4.2e-48
NP_002263 (OMIM: 123940,193900) keratin, type II c ( 520) 1643 183.0 1.9e-45
NP_005545 (OMIM: 148041,615726) keratin, type II c ( 564) 1622 180.9 8.8e-45
NP_775109 (OMIM: 612315,615735) keratin, type II c ( 564) 1615 180.2 1.5e-44
NP_000415 (OMIM: 131760,131800,131900,131960,14804 ( 590) 1615 180.2 1.5e-44
NP_005546 (OMIM: 148042,615728) keratin, type II c ( 564) 1613 180.0 1.7e-44
NP_778238 (OMIM: 608247) keratin, type II cytoskel ( 540) 1580 176.6 1.7e-43
NP_056932 (OMIM: 616671) keratin, type II cytoskel ( 638) 1567 175.3 4.9e-43
NP_006112 (OMIM: 113800,139350,144200,146590,60096 ( 644) 1562 174.8 7e-43
NP_787028 (OMIM: 611160) keratin, type II cytoskel ( 535) 1544 172.9 2.2e-42
NP_004684 (OMIM: 609025,612318) keratin, type II c ( 551) 1533 171.7 4.9e-42
NP_476429 (OMIM: 122100,148043) keratin, type II c ( 628) 1534 171.9 5e-42
NP_258259 (OMIM: 608245,615896) keratin, type II c ( 523) 1522 170.6 1e-41
NP_001139697 (OMIM: 608246) keratin, type II cytos ( 511) 1514 169.8 1.8e-41
NP_542785 (OMIM: 608246) keratin, type II cytoskel ( 511) 1514 169.8 1.8e-41
NP_778223 (OMIM: 194300,608248,613981,614929) kera ( 529) 1506 168.9 3.3e-41
NP_778253 (OMIM: 611158) keratin, type II cytoskel ( 578) 1457 163.9 1.1e-39
XP_016874238 (OMIM: 608245,615896) PREDICTED: kera ( 441) 1453 163.4 1.2e-39
NP_000414 (OMIM: 146800,600194) keratin, type II c ( 639) 1441 162.3 3.8e-39
XP_016874325 (OMIM: 608246) PREDICTED: keratin, ty ( 419) 1385 156.4 1.5e-37
XP_016874323 (OMIM: 608246) PREDICTED: keratin, ty ( 442) 1383 156.2 1.8e-37
NP_005547 (OMIM: 148059) keratin, type II cytoskel ( 469) 1375 155.4 3.4e-37
NP_001243211 (OMIM: 148060) keratin, type II cytos ( 511) 1362 154.1 9e-37
NP_001243222 (OMIM: 148060) keratin, type II cytos ( 483) 1361 154.0 9.3e-37
NP_002264 (OMIM: 148060) keratin, type II cytoskel ( 483) 1361 154.0 9.3e-37
XP_011536627 (OMIM: 148059) PREDICTED: keratin, ty ( 445) 1306 148.3 4.4e-35
XP_011536637 (OMIM: 602766) PREDICTED: keratin, ty ( 600) 1244 142.1 4.5e-33
NP_149034 (OMIM: 602766) keratin, type II cuticula ( 600) 1244 142.1 4.5e-33
XP_016874324 (OMIM: 608246) PREDICTED: keratin, ty ( 439) 1216 139.1 2.6e-32
NP_002274 (OMIM: 602032,602767) keratin, type II c ( 507) 1215 139.0 3.2e-32
XP_016874322 (OMIM: 608246) PREDICTED: keratin, ty ( 445) 1208 138.3 4.7e-32
NP_149022 (OMIM: 601078) keratin, type II cuticula ( 513) 1195 137.0 1.3e-31
NP_002272 (OMIM: 158000,602153) keratin, type II c ( 505) 1171 134.5 7.2e-31
NP_002273 (OMIM: 158000,602765) keratin, type II c ( 493) 1150 132.3 3.2e-30
NP_001307127 (OMIM: 158000,601928) keratin, type I ( 486) 1141 131.4 6e-30
XP_016874785 (OMIM: 158000,601928) PREDICTED: kera ( 486) 1141 131.4 6e-30
XP_005268923 (OMIM: 158000,601928) PREDICTED: kera ( 563) 1141 131.5 6.6e-30
NP_001139698 (OMIM: 608246) keratin, type II cytos ( 469) 994 116.3 2e-25
XP_011536590 (OMIM: 611158) PREDICTED: keratin, ty ( 345) 973 114.0 7.2e-25
NP_872313 (OMIM: 611161) keratin, type II cytoskel ( 452) 914 108.1 5.9e-23
NP_001074961 (OMIM: 611161) keratin, type II cytos ( 422) 911 107.7 7e-23
XP_016874783 (OMIM: 148059) PREDICTED: keratin, ty ( 292) 848 101.1 4.7e-21
XP_011536559 (OMIM: 608247) PREDICTED: keratin, ty ( 508) 850 101.5 6.2e-21
XP_016874326 (OMIM: 608246) PREDICTED: keratin, ty ( 271) 842 100.5 6.8e-21
XP_011536591 (OMIM: 611158) PREDICTED: keratin, ty ( 322) 701 86.1 1.8e-16
NP_003371 (OMIM: 116300,193060) vimentin [Homo sap ( 466) 692 85.3 4.5e-16
XP_006717563 (OMIM: 116300,193060) PREDICTED: vime ( 466) 692 85.3 4.5e-16
NP_001287739 (OMIM: 602032,602767) keratin, type I ( 295) 672 83.0 1.3e-15
>>NP_775487 (OMIM: 611159) keratin, type II cytoskeletal (520 aa)
initn: 3364 init1: 3364 opt: 3364 Z-score: 1892.7 bits: 359.8 E(85289): 1.1e-98
Smith-Waterman score: 3364; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB7 MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 RLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 QFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 GALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVFLSKMELEGKLEALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 GALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVFLSKMELEGKLEALR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 EYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 EYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 EALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 EALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 EQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 EQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 ECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 ECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIIL
430 440 450 460 470 480
490 500 510 520
pF1KB7 GSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY
::::::::::::::::::::::::::::::::::::::::
NP_775 GSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY
490 500 510 520
>>NP_001287743 (OMIM: 611159) keratin, type II cytoskele (410 aa)
initn: 2494 init1: 2494 opt: 2494 Z-score: 1411.0 bits: 270.4 E(85289): 7.5e-72
Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 393 aa overlap (128-520:18-410)
100 110 120 130 140 150
pF1KB7 IEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQG
::::::::::::::::::::::::::::::
NP_001 MEGHEASPAQVGQGDRGKVRFLEQQNKVLETKWHLLQQQGLSGSQQG
10 20 30 40
160 170 180 190 200 210
pF1KB7 LEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVV
50 60 70 80 90 100
220 230 240 250 260 270
pF1KB7 LKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLD
110 120 130 140 150 160
280 290 300 310 320 330
pF1KB7 FSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQ
170 180 190 200 210 220
340 350 360 370 380 390
pF1KB7 RLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQ
230 240 250 260 270 280
400 410 420 430 440 450
pF1KB7 ELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGL
290 300 310 320 330 340
460 470 480 490 500 510
pF1KB7 GSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTS
350 360 370 380 390 400
520
pF1KB7 ITY
:::
NP_001 ITY
410
>>XP_011536312 (OMIM: 611159) PREDICTED: keratin, type I (488 aa)
initn: 1739 init1: 1681 opt: 1728 Z-score: 984.6 bits: 191.7 E(85289): 4.2e-48
Smith-Waterman score: 3086; 93.8% identity (93.8% similar) in 520 aa overlap (1-520:1-488)
10 20 30 40 50 60
pF1KB7 MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 GALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVFLSKMELEGKLEALR
::::::::::::::::::::::::::::::::::::::::
XP_011 GALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKK--------------------
190 200 210 220
250 260 270 280 290 300
pF1KB7 EYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEA
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ------------ELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEA
230 240 250 260
310 320 330 340 350 360
pF1KB7 EALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDA
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB7 EQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGE
330 340 350 360 370 380
430 440 450 460 470 480
pF1KB7 ECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIIL
390 400 410 420 430 440
490 500 510 520
pF1KB7 GSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY
::::::::::::::::::::::::::::::::::::::::
XP_011 GSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY
450 460 470 480
>>NP_002263 (OMIM: 123940,193900) keratin, type II cytos (520 aa)
initn: 1616 init1: 1527 opt: 1643 Z-score: 937.1 bits: 183.0 E(85289): 1.9e-45
Smith-Waterman score: 1656; 55.3% identity (82.3% similar) in 497 aa overlap (9-494:26-517)
10 20 30 40
pF1KB7 MSLSPCRAQRG-FSARSACSARSRGRSRGGFSSRGGFSSRSLN
.:: ::. : .. .: : :::.::. .. :. .
NP_002 MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAGRCSS-GGFGSRSLYNLRGNK
10 20 30 40 50
50 60 70 80 90
pF1KB7 SF---------GGCLEGSRG-STWGSGGRLGVRFGEWSGGPGLSLCPPGGIQEVTINQNL
:. :.:. :. : .: : :: .: :. .::::. .:: ::::::::::.:
NP_002 SISMSVAGSRQGACFGGAGGFGTGGFGGGFGGSFSG-KGGPGFPVCPAGGIQEVTINQSL
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB7 LTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLS
::::..::::..: :::.: ..:. :::.::::::::.:::::::::::::.::::: .
NP_002 LTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTT
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB7 GSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLE
:...:::.::. :. :::::. : ...: :..:::. .:. :..:.::::: ..:.. :
NP_002 TSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAE
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB7 NDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDN
:::::::::::...:.:.:::.:...: . . ::: : . ::.:.::..:::::::::::
NP_002 NDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDN
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB7 NRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQL
:: ::..:::.::::.:::::. :::::::::::: :.::.:.. ::: ...:: .:..:
NP_002 NRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAEL
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB7 HQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARL
.. ::::... ::.::: .::....::::::: :::::..: ::::::..::..:::.
NP_002 NRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARM
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB7 LCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGGGLG
: ::::: :.::.::.::::::.:::::: :::::: : :.:: :.::. .::..::::
NP_002 LREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTS-TGGISGGLG
420 430 440 450 460 470
460 470 480 490 500 510
pF1KB7 STCGLGSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSGSSAGSSCHTILKKTVES
: :.: ..: .. ... ::: . ::... .... ...
NP_002 SGSGFGLSSGFGSGSGSGFGFGGS--VSGSSSSKIISTTTLNKRR
480 490 500 510 520
520
pF1KB7 SLKTSITY
>>NP_005545 (OMIM: 148041,615726) keratin, type II cytos (564 aa)
initn: 1594 init1: 1527 opt: 1622 Z-score: 924.9 bits: 180.9 E(85289): 8.8e-45
Smith-Waterman score: 1625; 53.1% identity (78.7% similar) in 520 aa overlap (11-517:55-561)
10 20 30
pF1KB7 MSLSPCRAQRGFSARSACSARSRGR-SRGGFSS--RGGFS
::..:: . . : : :: : ::..
NP_005 LPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYG
30 40 50 60 70 80
40 50 60 70 80
pF1KB7 SRSLNSFGGCLEGSRGSTWGSGGRLGVRFGEWSG--------GPGLSLCPPGGIQEVTIN
::. .:.: :. :: .: :: :. :: .: :::. .::::::::::.:
NP_005 SRAGGSYG---FGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVN
90 100 110 120 130 140
90 100 110 120 130 140
pF1KB7 QNLLTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQ
:.:::::...::: .: ::..: ..:.::::.:::::::::::::::::::::: :::.:
NP_005 QSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQ
150 160 170 180 190 200
150 160 170 180 190 200
pF1KB7 GLSGSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRA
: . .:.:::.:: ...::.::... :::: ::.::.. .: :..:.:::.: ..:.
NP_005 GTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRT
210 220 230 240 250 260
210 220 230 240 250 260
pF1KB7 TLENDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLS
. ::.::.::::::.....:.::..: ..: . . ::. : . ::.:.::. ::::::::
NP_005 AAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLS
270 280 290 300 310 320
270 280 290 300 310 320
pF1KB7 MDNNRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQI
::::: ::..:::.::.:.:::::. :.::::. :::::.::::.: ::: ...:: .:
NP_005 MDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEI
330 340 350 360 370 380
330 340 350 360 370 380
pF1KB7 SQLHQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNL
..... ::::.:. ...::: :.:::::.:::::::.:::::. :.. :: ::. :::.:
NP_005 AEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDL
390 400 410 420 430 440
390 400 410 420 430 440
pF1KB7 ARLLCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGG
:::: ::::: ..::.:::::::::.::::::::..:: ..::.:: : ....:.: ::
NP_005 ARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVV--QSTVSSGYGG
450 460 470 480 490
450 460 470 480 490 500
pF1KB7 GLGSTCGLGSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSG--SSAGSSCHTILK
. : ::: : :: : ... .::. . .::. ...: ::.:.. ::
NP_005 ASGVGSGLGLGGGSSYSYGSGLGVGGG-FSSSSGR-------AIGGGLSSVGGGSSTIKY
500 510 520 530 540 550
510 520
pF1KB7 KTVESSLKTSITY
:. :: . :
NP_005 TTTSSSSRKSYKH
560
>>NP_775109 (OMIM: 612315,615735) keratin, type II cytos (564 aa)
initn: 1585 init1: 1519 opt: 1615 Z-score: 921.0 bits: 180.2 E(85289): 1.5e-44
Smith-Waterman score: 1618; 52.9% identity (78.1% similar) in 520 aa overlap (11-517:55-561)
10 20 30
pF1KB7 MSLSPCRAQRGFSARSACSARSRGR-SRGGFSS--RGGFS
::..:: . . : : :: : ::..
NP_775 LPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYG
30 40 50 60 70 80
40 50 60 70 80
pF1KB7 SRSLNSFGGCLEGSRGSTWGSGGRLGVRFGEWSG--------GPGLSLCPPGGIQEVTIN
::. .:.: :. :: .: :: :. :: .: :::. .::::::::::.:
NP_775 SRAGGSYG---FGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVN
90 100 110 120 130 140
90 100 110 120 130 140
pF1KB7 QNLLTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQ
:.:::::...::: .: ::..: ..:.::::.::::::::::::::::::.::: :::.:
NP_775 QSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQ
150 160 170 180 190 200
150 160 170 180 190 200
pF1KB7 GLSGSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRA
: . .:.:::.:: ...::.::... :::: ::.::. .: :. :.:::.: ..:.
NP_775 GTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRT
210 220 230 240 250 260
210 220 230 240 250 260
pF1KB7 TLENDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLS
. ::.::.::::::.....:.::..: ..: . . ::. : . ::.:.::. ::::::::
NP_775 AAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLS
270 280 290 300 310 320
270 280 290 300 310 320
pF1KB7 MDNNRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQI
::::: ::..:::.::.:.:::::. :.::::. :::::.::::.: ::: ...:: .:
NP_775 MDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEI
330 340 350 360 370 380
330 340 350 360 370 380
pF1KB7 SQLHQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNL
..... ::::.:. ...::: :::::::.:::::::.:::::. :.. :: ::. :::.:
NP_775 AEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDL
390 400 410 420 430 440
390 400 410 420 430 440
pF1KB7 ARLLCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGG
:::: ::::: ..::.:::::::::.::::::::..:: ..::..: : ....:.: ::
NP_775 ARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNVSVV--QSTISSGYGG
450 460 470 480 490
450 460 470 480 490 500
pF1KB7 GLGSTCGLGSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSG--SSAGSSCHTILK
. : ::: : :: : ... ::. . .::. ...: ::.:.. ::
NP_775 ASGVGSGLGLGGGSSYSYGSGLGIGGG-FSSSSGR-------AIGGGLSSVGGGSSTIKY
500 510 520 530 540 550
510 520
pF1KB7 KTVESSLKTSITY
:. :: . :
NP_775 TTTSSSSRKSYKH
560
>>NP_000415 (OMIM: 131760,131800,131900,131960,148040,17 (590 aa)
initn: 1629 init1: 1547 opt: 1615 Z-score: 920.8 bits: 180.2 E(85289): 1.5e-44
Smith-Waterman score: 1624; 53.0% identity (78.3% similar) in 521 aa overlap (11-516:69-587)
10 20 30
pF1KB7 MSLSPCRAQRGFSAR-SACSARSRGRSRGGFSSRGGFSSR
: : : : .. . :.: : .. ::..
NP_000 GGGGGGGFGRVSLAGACGVGGYGSRSLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFG
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB7 SLNSFGGCLEGSRGSTWGSGGRLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIE
. . : . :. :. .: :: :. :: ::::. .::::::::::.::.:::::...
NP_000 GGAGSGFGFGGGAGGGFGLGG--GAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQ
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB7 IDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLE
:::..: :::.: ..:.::::.::::::::::::::::::.::: :::.:: . .:.::
NP_000 IDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLE
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB7 PVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLK
:.:: ...::.::... :::: ::.::. .: :..:.:::.: ..:.: ::.::.::
NP_000 PLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLK
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB7 KDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFS
::::.....:.:::.:..:: . . :.: . . ::.:.::..::::::::::::: ::..
NP_000 KDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLD
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB7 SIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRL
:::.::.:.::::: :..:::. :::::.::: .: ::: ...:: .::.... ::::
NP_000 SIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRL
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB7 QSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQEL
... .:.::: :.:: ::.:::::::::::::. :. ::: ::. :::..:::: :::::
NP_000 RAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQEL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB7 TSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSV--------GGSAVMSGGVGGGL
.:::.:::::::::.::::::::.::: .. :.:: : :... ..::.::::
NP_000 MNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYGSGSGYGGGLGGGL
460 470 480 490 500 510
460 470 480 490 500
pF1KB7 GSTCGLGSGKGSPGSCCTS----IVTGGSNIILGSGKDPVLD-SCSVS-GSSAGSSCHTI
:. : : . :: :: .: . ::. . ::: . . .:. ::..::: .
NP_000 GGGLGGGLAGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGRGLGVGFGSGGGSSSSVK
520 530 540 550 560 570
510 520
pF1KB7 LKKTVESSLKTSITY
. .:. :: :.
NP_000 FVSTTSSSRKSFKS
580 590
>>NP_005546 (OMIM: 148042,615728) keratin, type II cytos (564 aa)
initn: 1582 init1: 1516 opt: 1613 Z-score: 919.9 bits: 180.0 E(85289): 1.7e-44
Smith-Waterman score: 1613; 52.8% identity (77.6% similar) in 519 aa overlap (11-517:55-561)
10 20 30
pF1KB7 MSLSPCRAQRGFSARSACSARSRGR-SRGGFSS--RGGFS
::..:: . . : : :: : ::..
NP_005 LPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYG
30 40 50 60 70 80
40 50 60 70 80
pF1KB7 SRSLNSFGGCLEGSRGSTWGSGGRLGVRFGEWSG--------GPGLSLCPPGGIQEVTIN
::. .:.: :. :: .: :: :. :: .: :::. .::::::::::.:
NP_005 SRAGGSYG---FGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVN
90 100 110 120 130 140
90 100 110 120 130 140
pF1KB7 QNLLTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQ
:.:::::...::: .: ::..: ..:.::::.::::::::::::::::::.::: :::.:
NP_005 QSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQ
150 160 170 180 190 200
150 160 170 180 190 200
pF1KB7 GLSGSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRA
: . .:.:::.:: ...::.::... :::: ::.::. .: :. :.:::.: ..:.
NP_005 GTKTVRQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRT
210 220 230 240 250 260
210 220 230 240 250 260
pF1KB7 TLENDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLS
. ::.::.::::::.....:.::..: ..: . . ::. : . ::.:.::. ::::::::
NP_005 AAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLS
270 280 290 300 310 320
270 280 290 300 310 320
pF1KB7 MDNNRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQI
::::: ::..:::.::.:.:::::. :.::::. :::::.:::..: ::: ...:: .:
NP_005 MDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEI
330 340 350 360 370 380
330 340 350 360 370 380
pF1KB7 SQLHQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNL
..... ::::.:. ...::: :.:::::.:::::::.:::::. :.. :: ::. :::.:
NP_005 AEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDL
390 400 410 420 430 440
390 400 410 420 430 440
pF1KB7 ARLLCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGG
:::: ::::: ..::.:::::::::.::::::::..:: ..::.:: : ....:.: ::
NP_005 ARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVV--QSTVSSGYGG
450 460 470 480 490
450 460 470 480 490 500
pF1KB7 GLGSTCGLGSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSG-SSAGSSCHTILKK
. : ::: : :: : ::.. .:.: . . .: ::.:.. ::
NP_005 ASGVGSGLGLGGGSSYSY-------GSGLGVGGGFSSSSGRATGGGLSSVGGGSSTIKYT
500 510 520 530 540 550
510 520
pF1KB7 TVESSLKTSITY
:. :: . :
NP_005 TTSSSSRKSYKH
560
>>NP_778238 (OMIM: 608247) keratin, type II cytoskeletal (540 aa)
initn: 1585 init1: 1501 opt: 1580 Z-score: 901.9 bits: 176.6 E(85289): 1.7e-43
Smith-Waterman score: 1604; 55.0% identity (79.2% similar) in 505 aa overlap (8-495:13-509)
10 20 30 40
pF1KB7 MSLSPCRAQRGFSARSAC-SARSRGRSR-GGFSSRGGFSSRSLNSFGGC----LE
:. :::. :: :. : . : :: . :::::::: :.:: ..
NP_778 MSRQFTYKSGAAAKGGFSGCSAVLSGGSSSSYRAGGKGLSGGFSSRSLYSLGGARSISFN
10 20 30 40 50 60
50 60 70 80 90
pF1KB7 GSRGSTWGSG---GR------LGVRFGEWS-GGPGLSLCPPGGIQEVTINQNLLTPLKIE
. :: :..: :: : :: . :. ::::::::..::::..::.::..:
NP_778 VASGSGWAGGYGFGRGRASGFAGSMFGSVALGSVCPSLCPPGGIHQVTINKSLLAPLNVE
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB7 IDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLE
.::..: ::.:: ..:..:::.:::::::::::::::.::::::.:::: :.. ...::
NP_778 LDPEIQKVRAQEREQIKVLNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLE
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB7 PVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLK
:..:. ...:::::: :.:.: ::.::.. :. :.::..:::: ..:.: ::.:::::
NP_778 PILEGYISNLRKQLETLSGDRVRLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB7 KDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFS
::::... ::.::..:..:: . :.: : : : .:.:.. ::::..::::::: ::..
NP_778 KDVDAAYTSKVELQAKVDALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLD
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB7 SIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRL
:::.::::.::::::.::::::::::::.::::..: ::: ...:: .::.: . ::::
NP_778 SIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB7 QSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQEL
.:. :..::: :.:..::.::::::. :::::.::.::::.::..::..:::.: :::::
NP_778 RSEIESVKKQCANLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQEL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB7 TSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGGGLG-STCGLG
:.:::::.::::::.:::::::::::: :..:.:: ...: . .:.:.:.: :. :
NP_778 LSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVSISVINSSMAGMAGTGAGFGFSNAGTY
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB7 SGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSI
. : : :.. :: . ::: .:: :
NP_778 GYWPSSVSGGYSMLPGGC--VTGSG------NCSPRGEARTRLGSASEFRDSQGKTLALS
490 500 510 520 530
520
pF1KB7 TY
NP_778 SPTKKTMR
540
>>NP_056932 (OMIM: 616671) keratin, type II cytoskeletal (638 aa)
initn: 1513 init1: 1441 opt: 1567 Z-score: 893.7 bits: 175.3 E(85289): 4.9e-43
Smith-Waterman score: 1567; 55.9% identity (80.0% similar) in 506 aa overlap (11-500:80-575)
10 20 30
pF1KB7 MSLSPCRAQRGFSA-RSACS-ARSRGRSRGGFSSRGGFSS
::.. ::.:. : . : . :: : :::..
NP_056 AGSFGSRSLYNLGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGG-SYGGGFGG
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB7 -RSLNS-FGGCLEGSRGSTWGSGGRLGVRFGEWS-GGPGLSLCP---PGGIQEVTINQNL
:...: ::: :. :.. : :: :: : : :::: .. : ::::::: .::.:
NP_056 GRGVGSGFGGA--GGFGGAGGFGGP-GVFGGPGSFGGPG-GFGPGGFPGGIQEVIVNQSL
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB7 LTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLS
: ::..:::::. :..:: ..:.::::.::::::::::::::::::::::.::::: .
NP_056 LQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTG
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB7 GSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLE
.. ..::: ::. .. : :::..: :::: :..:::. .: :..:.:::.: ..:.. :
NP_056 SGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAE
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB7 NDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDN
:.:: ::::::..:..:.::..:...: . . ::. : : ::.:.:..::::::::::::
NP_056 NEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDN
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB7 NRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQL
:: ::..:::.::::.:::::. ::.::::::::: :::..: ::: ...:: .: .:
NP_056 NRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMEL
350 360 370 380 390 400
340 350 360 370 380 390
pF1KB7 HQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARL
.. ::::... ::.:::::.::.::..::::::.:::::.::...:..::. ::..::::
NP_056 NRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARL
410 420 430 440 450 460
400 410 420 430 440
pF1KB7 LCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVG---G
: .:::: ..::.:::::::::.::::::::::::: : : :: :.. . ::. : :
NP_056 LRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRG
470 480 490 500 510 520
450 460 470 480 490 500
pF1KB7 GLGSTCGLGSG--KGSPGSCCTSI--VTGGSNIILGSGKDPVLDSCSVSG-SSAGSSCHT
.:.. : ::: ::. .: .: :.::: ::: : .: :..: .:.::
NP_056 VFGGVSGSGSGGYKGGSSSSSSSGYGVSGGS----GSGYGGV-SSGSTGGRGSSGSYQSS
530 540 550 560 570
510 520
pF1KB7 ILKKTVESSLKTSITY
NP_056 SSGSRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK
580 590 600 610 620 630
520 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:17:44 2016 done: Fri Nov 4 06:17:45 2016
Total Scan time: 9.620 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]