Result of FASTA (omim) for
pF1KB6982
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6982, 246 aa
1>>>pF1KB6982 246 - 246 aa - 246 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4102+/-0.000425; mu= 13.0852+/- 0.026
mean_var=56.0433+/-11.084, 0's: 0 Z-trim(109.6): 37 B-trim: 242 in 1/50
Lambda= 0.171322
statistics sampled from 17820 (17855) to 17820 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.574), E-opt: 0.2 (0.209), width: 16
Scan time: 4.190
The best scores are: opt bits E(85289)
NP_002782 (OMIM: 602855,608446) proteasome subunit ( 246) 1619 408.5 5.4e-114
NP_001269163 (OMIM: 602855,608446) proteasome subu ( 227) 1452 367.3 1.3e-101
XP_016876957 (OMIM: 602855,608446) PREDICTED: prot ( 167) 1108 282.2 3.9e-76
NP_001269162 (OMIM: 602855,608446) proteasome subu ( 167) 1108 282.2 3.9e-76
NP_001269161 (OMIM: 602855,608446) proteasome subu ( 167) 1108 282.2 3.9e-76
NP_002778 (OMIM: 176842) proteasome subunit alpha ( 234) 465 123.3 3.7e-28
NP_001096137 (OMIM: 176846) proteasome subunit alp ( 261) 442 117.6 2.1e-26
NP_001317605 (OMIM: 176846) proteasome subunit alp ( 261) 442 117.6 2.1e-26
NP_002780 (OMIM: 176846) proteasome subunit alpha ( 261) 442 117.6 2.1e-26
NP_002783 (OMIM: 606607) proteasome subunit alpha ( 248) 439 116.9 3.4e-26
NP_002781 (OMIM: 176844) proteasome subunit alpha ( 241) 403 108.0 1.6e-23
NP_002779 (OMIM: 176843) proteasome subunit alpha ( 255) 391 105.0 1.3e-22
NP_001317602 (OMIM: 176846) proteasome subunit alp ( 174) 378 101.8 8.4e-22
NP_687033 (OMIM: 176843) proteasome subunit alpha ( 248) 369 99.6 5.5e-21
NP_002777 (OMIM: 602854) proteasome subunit alpha ( 263) 363 98.1 1.6e-20
NP_683877 (OMIM: 602854) proteasome subunit alpha ( 269) 363 98.1 1.7e-20
NP_001317604 (OMIM: 176846) proteasome subunit alp ( 230) 312 85.5 8.9e-17
NP_001096138 (OMIM: 176846) proteasome subunit alp ( 190) 281 77.8 1.5e-14
NP_001186701 (OMIM: 176844) proteasome subunit alp ( 183) 263 73.4 3.2e-13
NP_001186702 (OMIM: 176844) proteasome subunit alp ( 183) 263 73.4 3.2e-13
NP_001186703 (OMIM: 176844) proteasome subunit alp ( 183) 263 73.4 3.2e-13
NP_001137409 (OMIM: 602854) proteasome subunit alp ( 130) 206 59.2 4e-09
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 131 40.8 0.0027
>>NP_002782 (OMIM: 602855,608446) proteasome subunit alp (246 aa)
initn: 1619 init1: 1619 opt: 1619 Z-score: 2167.6 bits: 408.5 E(85289): 5.4e-114
Smith-Waterman score: 1619; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
190 200 210 220 230 240
pF1KB6 ALAERD
::::::
NP_002 ALAERD
>>NP_001269163 (OMIM: 602855,608446) proteasome subunit (227 aa)
initn: 1452 init1: 1452 opt: 1452 Z-score: 1945.1 bits: 367.3 E(85289): 1.3e-101
Smith-Waterman score: 1452; 100.0% identity (100.0% similar) in 221 aa overlap (26-246:7-227)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
:::::::::::::::::::::::::::::::::::
NP_001 MAGLRREYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
10 20 30 40
70 80 90 100 110 120
pF1KB6 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB6 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB6 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
170 180 190 200 210 220
pF1KB6 ALAERD
::::::
NP_001 ALAERD
>>XP_016876957 (OMIM: 602855,608446) PREDICTED: proteaso (167 aa)
initn: 1108 init1: 1108 opt: 1108 Z-score: 1487.8 bits: 282.2 E(85289): 3.9e-76
Smith-Waterman score: 1108; 100.0% identity (100.0% similar) in 167 aa overlap (80-246:1-167)
50 60 70 80 90 100
pF1KB6 IVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEI
::::::::::::::::::::::::::::::
XP_016 MTGMTADSRSQVQRARYEAANWKYKYGYEI
10 20 30
110 120 130 140 150 160
pF1KB6 PVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAG
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 VKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRI
100 110 120 130 140 150
230 240
pF1KB6 LTEAEIDAHLVALAERD
:::::::::::::::::
XP_016 LTEAEIDAHLVALAERD
160
>>NP_001269162 (OMIM: 602855,608446) proteasome subunit (167 aa)
initn: 1108 init1: 1108 opt: 1108 Z-score: 1487.8 bits: 282.2 E(85289): 3.9e-76
Smith-Waterman score: 1108; 100.0% identity (100.0% similar) in 167 aa overlap (80-246:1-167)
50 60 70 80 90 100
pF1KB6 IVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEI
::::::::::::::::::::::::::::::
NP_001 MTGMTADSRSQVQRARYEAANWKYKYGYEI
10 20 30
110 120 130 140 150 160
pF1KB6 PVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAG
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 VKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRI
100 110 120 130 140 150
230 240
pF1KB6 LTEAEIDAHLVALAERD
:::::::::::::::::
NP_001 LTEAEIDAHLVALAERD
160
>>NP_001269161 (OMIM: 602855,608446) proteasome subunit (167 aa)
initn: 1108 init1: 1108 opt: 1108 Z-score: 1487.8 bits: 282.2 E(85289): 3.9e-76
Smith-Waterman score: 1108; 100.0% identity (100.0% similar) in 167 aa overlap (80-246:1-167)
50 60 70 80 90 100
pF1KB6 IVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEI
::::::::::::::::::::::::::::::
NP_001 MTGMTADSRSQVQRARYEAANWKYKYGYEI
10 20 30
110 120 130 140 150 160
pF1KB6 PVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAG
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 VKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRI
100 110 120 130 140 150
230 240
pF1KB6 LTEAEIDAHLVALAERD
:::::::::::::::::
NP_001 LTEAEIDAHLVALAERD
160
>>NP_002778 (OMIM: 176842) proteasome subunit alpha type (234 aa)
initn: 423 init1: 235 opt: 465 Z-score: 626.4 bits: 123.3 E(85289): 3.7e-28
Smith-Waterman score: 465; 35.6% identity (67.4% similar) in 236 aa overlap (8-243:5-234)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
:.. .: ::: :.: :.:::. :. :: ::.... . .:..:.:: . :
NP_002 MAERGYSFSLTTFSPSGKLVQIEYALAAVA-GGAPSVGIKAANGVVLATEKKQKSIL
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
: .: .. ::..:: :..:: : : :.::: : .. : ::. .: .:.:.
NP_002 YDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVAS
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
. : :::.. .::.: ... : .: . : ... ::.: : ..:::: : . ... .:::
NP_002 VMQEYTQSGGVRPFGVSLLICGWNEGR-PYLFQSDPSGAYFAWKATAMGKNYVNGKTFLE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
:. .. : .:....::: :. . .. ..::::. .. :: :: .:. .:.
NP_002 KRYNE--DLELEDAIHTAILTLKESFEGQMTEDNIEVGIC--NEAGFRRLTPTEVKDYLA
180 190 200 210 220 230
pF1KB6 ALAERD
:.:
NP_002 AIA
>>NP_001096137 (OMIM: 176846) proteasome subunit alpha t (261 aa)
initn: 360 init1: 360 opt: 442 Z-score: 594.9 bits: 117.6 E(85289): 2.1e-26
Smith-Waterman score: 442; 32.8% identity (70.7% similar) in 232 aa overlap (9-236:5-234)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
.: . :::::::::::::::..::...: : ... ..: ........ ::
NP_001 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAG-TCLGILANDGVLLAAERRNIHKL
10 20 30 40 50
70 80 90 100 110
pF1KB6 LDSSTVTH-LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIA
:: .. ..:..:...: ..:.:.:. ... : : . .: :: ..: .
NP_001 LDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 DISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFL
::.:.::: . ::.: .. :: :.. : :.:. ::.: : :.::: : ... ..:.:
NP_001 DIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSML
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 EKKVKKKFDWTFEQTVETAITCLSTVLSID-FKPSEIEVGVVTVENPK--FRILTEAEID
.. :. . :..... :: :. ..... .. ..:....: :: : .:.: . :..
NP_001 KQDYKEG-EMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVE
180 190 200 210 220 230
240
pF1KB6 AHLVALAERD
NP_001 QLIKKHEEEEAKAEREKKEKEQKEKDK
240 250 260
>>NP_001317605 (OMIM: 176846) proteasome subunit alpha t (261 aa)
initn: 360 init1: 360 opt: 442 Z-score: 594.9 bits: 117.6 E(85289): 2.1e-26
Smith-Waterman score: 442; 32.8% identity (70.7% similar) in 232 aa overlap (9-236:5-234)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
.: . :::::::::::::::..::...: : ... ..: ........ ::
NP_001 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAG-TCLGILANDGVLLAAERRNIHKL
10 20 30 40 50
70 80 90 100 110
pF1KB6 LDSSTVTH-LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIA
:: .. ..:..:...: ..:.:.:. ... : : . .: :: ..: .
NP_001 LDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 DISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFL
::.:.::: . ::.: .. :: :.. : :.:. ::.: : :.::: : ... ..:.:
NP_001 DIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSML
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 EKKVKKKFDWTFEQTVETAITCLSTVLSID-FKPSEIEVGVVTVENPK--FRILTEAEID
.. :. . :..... :: :. ..... .. ..:....: :: : .:.: . :..
NP_001 KQDYKEG-EMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVE
180 190 200 210 220 230
240
pF1KB6 AHLVALAERD
NP_001 QLIKKHEEEEAKAEREKKEKEQKEKDK
240 250 260
>>NP_002780 (OMIM: 176846) proteasome subunit alpha type (261 aa)
initn: 360 init1: 360 opt: 442 Z-score: 594.9 bits: 117.6 E(85289): 2.1e-26
Smith-Waterman score: 442; 32.8% identity (70.7% similar) in 232 aa overlap (9-236:5-234)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
.: . :::::::::::::::..::...: : ... ..: ........ ::
NP_002 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAG-TCLGILANDGVLLAAERRNIHKL
10 20 30 40 50
70 80 90 100 110
pF1KB6 LDSSTVTH-LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIA
:: .. ..:..:...: ..:.:.:. ... : : . .: :: ..: .
NP_002 LDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 DISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFL
::.:.::: . ::.: .. :: :.. : :.:. ::.: : :.::: : ... ..:.:
NP_002 DIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSML
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 EKKVKKKFDWTFEQTVETAITCLSTVLSID-FKPSEIEVGVVTVENPK--FRILTEAEID
.. :. . :..... :: :. ..... .. ..:....: :: : .:.: . :..
NP_002 KQDYKEG-EMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVE
180 190 200 210 220 230
240
pF1KB6 AHLVALAERD
NP_002 QLIKKHEEEEAKAEREKKEKEQKEKDK
240 250 260
>>NP_002783 (OMIM: 606607) proteasome subunit alpha type (248 aa)
initn: 308 init1: 308 opt: 439 Z-score: 591.3 bits: 116.9 E(85289): 3.4e-26
Smith-Waterman score: 439; 34.5% identity (66.0% similar) in 238 aa overlap (9-246:3-235)
10 20 30 40 50 60
pF1KB6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
.:: ::.:::.:.:.::::: .:...:. :.:.:::.: .:. ..:: ::
NP_002 MSYDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGVRGRDIVVLGVEKKSVAKL
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
: :: .. . .:. ...:.:::.: ..::: : . . . :... . ::.
NP_002 QDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIAS
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
..: :::. ::.: ...:.: . :..:. ::.: : ..::.: : :::
NP_002 LKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
:. . : . :.. .: : :.. : .::..:. .. ...::. ::. . :
NP_002 KNYTDEAIETDDLTIKLVIKALLEVVQSGGK--NIELAVMR-RDQSLKILNPEEIEKY-V
180 190 200 210 220
pF1KB6 ALAERD
: :..
NP_002 AEIEKEKEENEKKKQKKAS
230 240
246 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:44:18 2016 done: Fri Nov 4 10:44:19 2016
Total Scan time: 4.190 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]