Result of FASTA (omim) for
pF1KB6980
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6980, 245 aa
1>>>pF1KB6980 245 - 245 aa - 245 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2507+/-0.000351; mu= 14.9851+/- 0.022
mean_var=64.3820+/-13.027, 0's: 0 Z-trim(112.8): 14 B-trim: 0 in 0/50
Lambda= 0.159842
statistics sampled from 21803 (21814) to 21803 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.256), width: 16
Scan time: 5.930
The best scores are: opt bits E(85289)
NP_061910 (OMIM: 606491) exosome complex component ( 245) 1592 375.7 4.2e-104
XP_011515436 (OMIM: 606491) PREDICTED: exosome com ( 147) 941 225.4 4.2e-59
NP_478126 (OMIM: 606490) exosome complex component ( 272) 274 71.8 1.4e-12
NP_064543 (OMIM: 606492) exosome complex component ( 235) 231 61.8 1.2e-09
XP_005264686 (OMIM: 610316,614932,614934) PREDICTE ( 703) 146 42.5 0.0024
XP_016860661 (OMIM: 610316,614932,614934) PREDICTE ( 703) 146 42.5 0.0024
NP_149100 (OMIM: 610316,614932,614934) polyribonuc ( 783) 146 42.5 0.0026
>>NP_061910 (OMIM: 606491) exosome complex component RRP (245 aa)
initn: 1592 init1: 1592 opt: 1592 Z-score: 1990.0 bits: 375.7 E(85289): 4.2e-104
Smith-Waterman score: 1592; 100.0% identity (100.0% similar) in 245 aa overlap (1-245:1-245)
10 20 30 40 50 60
pF1KB6 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 SRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 SRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 IDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 IDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 GGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 GGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREAS
190 200 210 220 230 240
pF1KB6 ILLGD
:::::
NP_061 ILLGD
>>XP_011515436 (OMIM: 606491) PREDICTED: exosome complex (147 aa)
initn: 941 init1: 941 opt: 941 Z-score: 1182.1 bits: 225.4 E(85289): 4.2e-59
Smith-Waterman score: 941; 100.0% identity (100.0% similar) in 147 aa overlap (99-245:1-147)
70 80 90 100 110 120
pF1KB6 RALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVL
::::::::::::::::::::::::::::::
XP_011 MGLQLRQTFEAAILTQLHPRSQIDIYVQVL
10 20 30
130 140 150 160 170 180
pF1KB6 QADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALA
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB6 LLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD
100 110 120 130 140
>>NP_478126 (OMIM: 606490) exosome complex component MTR (272 aa)
initn: 256 init1: 136 opt: 274 Z-score: 346.8 bits: 71.8 E(85289): 1.4e-12
Smith-Waterman score: 359; 34.2% identity (65.8% similar) in 196 aa overlap (17-199:31-225)
10 20 30 40
pF1KB6 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNT
: .:: . :: :...:: ::::.: :.:
NP_478 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT
10 20 30 40 50 60
50 60 70 80 90
pF1KB6 KALAVVYGPHEIRGSRARALPD----------RALVNCQYSSATFSTGERKRRPHGDRKS
:.: .: ::.. .:.. . : :. . :.. : :. :.:.: : : .
NP_478 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFA-GRRRRAPPGGCEE
70 80 90 100 110
100 110 120 130 140 150
pF1KB6 CEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDF
:..: :....: :. .::.:... . .:. :.. :: ..::.::. :::. : :.
NP_478 RELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 VCACSAGFVDGTA---LADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERV
: .:. ... : : : : ...:: .. :..::.:. .:.: :
NP_478 VVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAE
180 190 200 210 220 230
220 230 240
pF1KB6 LEAAAQAARDVHTLLDRVVRQHVREASILLGD
NP_478 AVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP
240 250 260 270
>>NP_064543 (OMIM: 606492) exosome complex component RRP (235 aa)
initn: 284 init1: 190 opt: 231 Z-score: 294.1 bits: 61.8 E(85289): 1.2e-09
Smith-Waterman score: 300; 33.3% identity (60.8% similar) in 204 aa overlap (22-221:28-216)
10 20 30 40 50
pF1KB6 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYG
::.. ....... :::: . ::.:..:: :::
NP_064 MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 PHEIRGSRARALPDRALVNCQYSSATFSTGERKR--RPHGDRKSCEMGLQLRQTFEAAIL
: :.. :. ...::. . : . : .:: : .:.: ::..:
NP_064 PAEVKVSKE-----------IFNKATLEVILRPKIGLPGVAEKSRER--LIRNTCEAVVL
70 80 90 100
120 130 140 150 160 170
pF1KB6 TQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVC--ACSAGFVDGTAL
::::..: . .::.. :. : :.::: .:..:::.::: . : ::. ::: .
NP_064 GTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALD-SDGTLV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 ADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDR
: . .: . :..:: . .. . . . .:.. : ::::::
NP_064 LDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCL-AAAQAASQHVFRFYR
170 180 190 200 210 220
240
pF1KB6 VVRQHVREASILLGD
NP_064 ESLQRRYSKS
230
>>XP_005264686 (OMIM: 610316,614932,614934) PREDICTED: p (703 aa)
initn: 101 init1: 79 opt: 146 Z-score: 181.0 bits: 42.5 E(85289): 0.0024
Smith-Waterman score: 171; 21.0% identity (56.4% similar) in 243 aa overlap (13-234:278-515)
10 20 30 40
pF1KB6 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIE
: ::: ::... .. .: ::: ..
XP_005 FPEADPYEIIESFNVVAKEVFRSIVLNEYKRCDGRDLTSLRNVSCEVDMFKTLHGSALFQ
250 260 270 280 290 300
50 60 70 80 90
pF1KB6 QGNTKAL-AVVYGPHE--IRGSRA----RALPDRALVNCQYSSATFSTGERKRRPHGDRK
.:.:..: .:.. : :..... .. :. .. .: ..:.: . .:.
XP_005 RGQTQVLCTVTFDSLESGIKSDQVITAINGIKDKNFM-LHYEFPPYATNEIGKVTGLNRR
310 320 330 340 350 360
100 110 120 130 140 150
pF1KB6 SCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRD
: .... .. . : . : . .::...:.. : . ...::..:.:.:. .
XP_005 ELGHGALAEKALYP-VIPRDFPFT-IRVTSEVLESNGSSSMASACGGSLALMDSGVPISS
370 380 390 400 410 420
160 170 180 190 200
pF1KB6 FVCACSAGFV-----------DGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDAR
: . . :.: : :.:. .:. : .. .: .. :. :. : .
XP_005 AVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYNGDMDFKIA--GTNKGITALQADIK
430 440 450 460 470 480
210 220 230 240
pF1KB6 LHEDHLERVLEAAAQAA---RDVHTLLDRVVRQHVREASILLGD
: .. :.:: ::. ... ...... .
XP_005 LPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVG
490 500 510 520 530 540
XP_005 PGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEARDFITEICKDDQEQQLEFGAVY
550 560 570 580 590 600
>>XP_016860661 (OMIM: 610316,614932,614934) PREDICTED: p (703 aa)
initn: 101 init1: 79 opt: 146 Z-score: 181.0 bits: 42.5 E(85289): 0.0024
Smith-Waterman score: 171; 21.0% identity (56.4% similar) in 243 aa overlap (13-234:278-515)
10 20 30 40
pF1KB6 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIE
: ::: ::... .. .: ::: ..
XP_016 FPEADPYEIIESFNVVAKEVFRSIVLNEYKRCDGRDLTSLRNVSCEVDMFKTLHGSALFQ
250 260 270 280 290 300
50 60 70 80 90
pF1KB6 QGNTKAL-AVVYGPHE--IRGSRA----RALPDRALVNCQYSSATFSTGERKRRPHGDRK
.:.:..: .:.. : :..... .. :. .. .: ..:.: . .:.
XP_016 RGQTQVLCTVTFDSLESGIKSDQVITAINGIKDKNFM-LHYEFPPYATNEIGKVTGLNRR
310 320 330 340 350 360
100 110 120 130 140 150
pF1KB6 SCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRD
: .... .. . : . : . .::...:.. : . ...::..:.:.:. .
XP_016 ELGHGALAEKALYP-VIPRDFPFT-IRVTSEVLESNGSSSMASACGGSLALMDSGVPISS
370 380 390 400 410 420
160 170 180 190 200
pF1KB6 FVCACSAGFV-----------DGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDAR
: . . :.: : :.:. .:. : .. .: .. :. :. : .
XP_016 AVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYNGDMDFKIA--GTNKGITALQADIK
430 440 450 460 470 480
210 220 230 240
pF1KB6 LHEDHLERVLEAAAQAA---RDVHTLLDRVVRQHVREASILLGD
: .. :.:: ::. ... ...... .
XP_016 LPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVG
490 500 510 520 530 540
XP_016 PGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEARDFITEICKDDQEQQLEFGAVY
550 560 570 580 590 600
>>NP_149100 (OMIM: 610316,614932,614934) polyribonucleot (783 aa)
initn: 140 init1: 79 opt: 146 Z-score: 180.3 bits: 42.5 E(85289): 0.0026
Smith-Waterman score: 171; 21.0% identity (56.4% similar) in 243 aa overlap (13-234:358-595)
10 20 30 40
pF1KB6 MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIE
: ::: ::... .. .: ::: ..
NP_149 FPEADPYEIIESFNVVAKEVFRSIVLNEYKRCDGRDLTSLRNVSCEVDMFKTLHGSALFQ
330 340 350 360 370 380
50 60 70 80 90
pF1KB6 QGNTKAL-AVVYGPHE--IRGSRA----RALPDRALVNCQYSSATFSTGERKRRPHGDRK
.:.:..: .:.. : :..... .. :. .. .: ..:.: . .:.
NP_149 RGQTQVLCTVTFDSLESGIKSDQVITAINGIKDKNFM-LHYEFPPYATNEIGKVTGLNRR
390 400 410 420 430 440
100 110 120 130 140 150
pF1KB6 SCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRD
: .... .. . : . : . .::...:.. : . ...::..:.:.:. .
NP_149 ELGHGALAEKALYP-VIPRDFPFT-IRVTSEVLESNGSSSMASACGGSLALMDSGVPISS
450 460 470 480 490 500
160 170 180 190 200
pF1KB6 FVCACSAGFV-----------DGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDAR
: . . :.: : :.:. .:. : .. .: .. :. :. : .
NP_149 AVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYNGDMDFKIA--GTNKGITALQADIK
510 520 530 540 550 560
210 220 230 240
pF1KB6 LHEDHLERVLEAAAQAA---RDVHTLLDRVVRQHVREASILLGD
: .. :.:: ::. ... ...... .
NP_149 LPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVG
570 580 590 600 610 620
NP_149 PGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEARDFITEICKDDQEQQLEFGAVY
630 640 650 660 670 680
245 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:47:51 2016 done: Fri Nov 4 10:47:52 2016
Total Scan time: 5.930 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]