Result of FASTA (omim) for
pF1KB6535
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6535, 367 aa
1>>>pF1KB6535 367 - 367 aa - 367 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7105+/-0.000339; mu= -2.7441+/- 0.021
mean_var=241.7938+/-49.085, 0's: 0 Z-trim(123.0): 9 B-trim: 0 in 0/62
Lambda= 0.082481
statistics sampled from 42105 (42116) to 42105 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.494), width: 16
Scan time: 10.070
The best scores are: opt bits E(85289)
NP_001613 (OMIM: 138680) alpha-2-HS-glycoprotein p ( 367) 2542 314.9 1.9e-85
XP_016861329 (OMIM: 138680) PREDICTED: alpha-2-HS- ( 339) 1557 197.6 3.4e-50
NP_055190 (OMIM: 605954) fetuin-B isoform 1 precur ( 382) 385 58.2 3.6e-08
XP_011510983 (OMIM: 605954) PREDICTED: fetuin-B is ( 382) 385 58.2 3.6e-08
XP_011510984 (OMIM: 605954) PREDICTED: fetuin-B is ( 277) 252 42.3 0.0016
NP_001295006 (OMIM: 605954) fetuin-B isoform 2 pre ( 345) 251 42.2 0.0021
NP_001295008 (OMIM: 605954) fetuin-B isoform 3 pre ( 317) 235 40.3 0.0073
>>NP_001613 (OMIM: 138680) alpha-2-HS-glycoprotein prepr (367 aa)
initn: 2542 init1: 2542 opt: 2542 Z-score: 1655.1 bits: 314.9 E(85289): 1.9e-85
Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367)
10 20 30 40 50 60
pF1KB6 MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 AEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG
310 320 330 340 350 360
pF1KB6 RIRHFKV
:::::::
NP_001 RIRHFKV
>>XP_016861329 (OMIM: 138680) PREDICTED: alpha-2-HS-glyc (339 aa)
initn: 1573 init1: 1540 opt: 1557 Z-score: 1022.2 bits: 197.6 E(85289): 3.4e-50
Smith-Waterman score: 2290; 92.4% identity (92.4% similar) in 367 aa overlap (1-367:1-339)
10 20 30 40 50 60
pF1KB6 MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGG
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEK---------------
190 200 210 220
250 260 270 280 290 300
pF1KB6 AEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -------------PVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL
230 240 250 260 270
310 320 330 340 350 360
pF1KB6 LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG
280 290 300 310 320 330
pF1KB6 RIRHFKV
:::::::
XP_016 RIRHFKV
>>NP_055190 (OMIM: 605954) fetuin-B isoform 1 precursor (382 aa)
initn: 245 init1: 116 opt: 385 Z-score: 267.7 bits: 58.2 E(85289): 3.6e-08
Smith-Waterman score: 396; 27.6% identity (55.6% similar) in 381 aa overlap (5-357:11-382)
10 20 30 40 50
pF1KB6 MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPW
.:.:: . . . : . .:. : .:.: .. .: :. ::..
NP_055 MGLLLPLALCILVLCCGAMSPPQLALNPSALLSR--GCNDSDVLAVAGFALRDINKDRKD
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 GYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDC
:: ::...... . . : :: . .:.::: :::: :..: . : .: :.:
NP_055 GYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFE-SVYGQC
60 70 80 90 100 110
120 130 140 150 160
pF1KB6 DFQLLKLDGKFSVVYA---KCDSSPDSAEDVRKVCQDCPLLAPLNDT--RVVHAAKAALA
.. ... :.: .: : : . . .: ::: : ... .:..:: .::
NP_055 K-AIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 AFNAQNNGSNFQLEEISRA--QLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQY
.: .:......: ...:: : : . :: .::. .. . :. ..:..:.: . .
NP_055 KYNNENTSKQYSLFKVTRASSQWV-VGPSYFVEYLIKESPCTK---SQASSCSLQSSDSV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 --GFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPT--PVVDPDAPP-SPP
:.::..:.. :.::: :..: .. . ..:. :: : :. . .::
NP_055 PVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQK-PTNLPKVEESQQKNTPP
240 250 260 270 280 290
290 300 310 320 330
pF1KB6 LGAPGLP-PAGSP---PDSHVLLAAPPGHQ-LHRAHYDLRHTFMGV---VSLG--SPSGE
.:. : :: :: . : : .: :: . .: .:. : :
NP_055 TDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEE
300 310 320 330 340 350
340 350 360
pF1KB6 ----VSHPR-KTRTVVQPSVGAAAGPVV-PPCPGRIRHFKV
. :. :.::. :. . :.:.: ::
NP_055 KLVVLPFPKEKARTAECPGPAQNASPLVLPP
360 370 380
>>XP_011510983 (OMIM: 605954) PREDICTED: fetuin-B isofor (382 aa)
initn: 245 init1: 116 opt: 385 Z-score: 267.7 bits: 58.2 E(85289): 3.6e-08
Smith-Waterman score: 396; 27.6% identity (55.6% similar) in 381 aa overlap (5-357:11-382)
10 20 30 40 50
pF1KB6 MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPW
.:.:: . . . : . .:. : .:.: .. .: :. ::..
XP_011 MGLLLPLALCILVLCCGAMSPPQLALNPSALLSR--GCNDSDVLAVAGFALRDINKDRKD
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 GYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDC
:: ::...... . . : :: . .:.::: :::: :..: . : .: :.:
XP_011 GYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFE-SVYGQC
60 70 80 90 100 110
120 130 140 150 160
pF1KB6 DFQLLKLDGKFSVVYA---KCDSSPDSAEDVRKVCQDCPLLAPLNDT--RVVHAAKAALA
.. ... :.: .: : : . . .: ::: : ... .:..:: .::
XP_011 K-AIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 AFNAQNNGSNFQLEEISRA--QLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQY
.: .:......: ...:: : : . :: .::. .. . :. ..:..:.: . .
XP_011 KYNNENTSKQYSLFKVTRASSQWV-VGPSYFVEYLIKESPCTK---SQASSCSLQSSDSV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 --GFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPT--PVVDPDAPP-SPP
:.::..:.. :.::: :..: .. . ..:. :: : :. . .::
XP_011 PVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQK-PTNLPKVEESQQKNTPP
240 250 260 270 280 290
290 300 310 320 330
pF1KB6 LGAPGLP-PAGSP---PDSHVLLAAPPGHQ-LHRAHYDLRHTFMGV---VSLG--SPSGE
.:. : :: :: . : : .: :: . .: .:. : :
XP_011 TDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEE
300 310 320 330 340 350
340 350 360
pF1KB6 ----VSHPR-KTRTVVQPSVGAAAGPVV-PPCPGRIRHFKV
. :. :.::. :. . :.:.: ::
XP_011 KLVVLPFPKEKARTAECPGPAQNASPLVLPP
360 370 380
>>XP_011510984 (OMIM: 605954) PREDICTED: fetuin-B isofor (277 aa)
initn: 163 init1: 103 opt: 252 Z-score: 184.2 bits: 42.3 E(85289): 0.0016
Smith-Waterman score: 257; 26.7% identity (55.6% similar) in 277 aa overlap (109-357:7-277)
80 90 100 110 120 130
pF1KB6 EIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYA---KCDSS
.: :.: .. ... :.: .:
XP_011 MRIFFESVYGQCK-AIFYMNNPSRVLYLAAYNCTLR
10 20 30
140 150 160 170 180 190
pF1KB6 PDSAEDVRKVCQDCPLLAPLNDT--RVVHAAKAALAAFNAQNNGSNFQLEEISRA--QLV
: : . . .: ::: : ... .:..:: .:: .: .:......: ...:: : :
XP_011 PVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWV
40 50 60 70 80 90
200 210 220 230 240
pF1KB6 PLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQY--GFCKATLSEKLGGAEVAVTCMV
. :: .::. .. . :. ..:..:.: . . :.::..:.. :.:::
XP_011 -VGPSYFVEYLIKESPCT---KSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDF
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 FQTQPVSSQPQPEGANEAVPT--PVVDPDAPP-SPPLGAPGLP-PAGSP---PDSHVLLA
:..: .. . ..:. :: : :. . .:: .:. : :: :: .
XP_011 FESQAPATGSENSAVNQK-PTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNS
160 170 180 190 200 210
310 320 330 340 350
pF1KB6 APPGHQ-LHRAHYDLRHTFMG-VVSLG----SPSGE----VSHPR-KTRTVVQPSVGAAA
: : .: :: . .: ..... : : . :. :.::. :. . :
XP_011 QEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNA
220 230 240 250 260 270
360
pF1KB6 GPVV-PPCPGRIRHFKV
.:.: ::
XP_011 SPLVLPP
>>NP_001295006 (OMIM: 605954) fetuin-B isoform 2 precurs (345 aa)
initn: 188 init1: 103 opt: 251 Z-score: 182.2 bits: 42.2 E(85289): 0.0021
Smith-Waterman score: 256; 26.8% identity (55.4% similar) in 276 aa overlap (110-357:76-345)
80 90 100 110 120 130
pF1KB6 IEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYA---KCDSSP
: :.: .. ... :.: .: :
NP_001 GFALRDINKDRKDGYVLRLNRVNDAQEYRRVYGQCK-AIFYMNNPSRVLYLAAYNCTLRP
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB6 DSAEDVRKVCQDCPLLAPLNDT--RVVHAAKAALAAFNAQNNGSNFQLEEISRA--QLVP
: . . .: ::: : ... .:..:: .:: .: .:......: ...:: : :
NP_001 VSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWV-
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB6 LPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQY--GFCKATLSEKLGGAEVAVTCMVF
. :: .::. .. . :. ..:..:.: . . :.::..:.. :.::: :
NP_001 VGPSYFVEYLIKESPCTK---SQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFF
170 180 190 200 210 220
260 270 280 290 300
pF1KB6 QTQPVSSQPQPEGANEAVPT--PVVDPDAPP-SPPLGAPGLP-PAGSP---PDSHVLLAA
..: .. . ..:. :: : :. . .:: .:. : :: :: .
NP_001 ESQAPATGSENSAVNQK-PTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQ
230 240 250 260 270
310 320 330 340 350
pF1KB6 PPGHQ-LHRAHYDLRHTFMG-VVSLG----SPSGE----VSHPR-KTRTVVQPSVGAAAG
: : .: :: . .: ..... : : . :. :.::. :. . :.
NP_001 EKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNAS
280 290 300 310 320 330
360
pF1KB6 PVV-PPCPGRIRHFKV
:.: ::
NP_001 PLVLPP
340
>>NP_001295008 (OMIM: 605954) fetuin-B isoform 3 precurs (317 aa)
initn: 182 init1: 103 opt: 235 Z-score: 172.4 bits: 40.3 E(85289): 0.0073
Smith-Waterman score: 240; 26.2% identity (54.0% similar) in 298 aa overlap (85-357:32-317)
60 70 80 90 100 110
pF1KB6 GYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDC
: :. : :: ..:.... .:
NP_001 GLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDG--
10 20 30 40 50
120 130 140 150 160 170
pF1KB6 DFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDT--RVVHAAKAALAAFN
.:.:. : :. : . . .: ::: : ... .:..:: .:: .:
NP_001 --YVLRLN---RVNDAQEYRRAISKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYN
60 70 80 90 100 110
180 190 200 210 220
pF1KB6 AQNNGSNFQLEEISRA--QLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQY--G
.:......: ...:: : : . :: .::. .. . :. ..:..:.: . . :
NP_001 NENTSKQYSLFKVTRASSQWV-VGPSYFVEYLIKESPCTK---SQASSCSLQSSDSVPVG
120 130 140 150 160 170
230 240 250 260 270 280
pF1KB6 FCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPT--PVVDPDAPP-SPPLGA
.::..:.. :.::: :..: .. . ..:. :: : :. . .:: .
NP_001 LCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQK-PTNLPKVEESQQKNTPPTDS
180 190 200 210 220
290 300 310 320 330
pF1KB6 PGLP-PAGSP---PDSHVLLAAPPGHQ-LHRAHYDLRHTFMG-VVSLG----SPSGE---
:. : :: :: . : : .: :: . .: ..... : :
NP_001 PSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLV
230 240 250 260 270 280
340 350 360
pF1KB6 -VSHPR-KTRTVVQPSVGAAAGPVV-PPCPGRIRHFKV
. :. :.::. :. . :.:.: ::
NP_001 VLPFPKEKARTAECPGPAQNASPLVLPP
290 300 310
367 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 16:55:42 2016 done: Sat Nov 5 16:55:43 2016
Total Scan time: 10.070 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]