Result of FASTA (omim) for
pF1KB6284
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6284, 783 aa
1>>>pF1KB6284 783 - 783 aa - 783 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6963+/-0.000413; mu= -8.3335+/- 0.026
mean_var=428.9258+/-86.712, 0's: 0 Z-trim(123.4): 52 B-trim: 0 in 0/59
Lambda= 0.061927
statistics sampled from 43109 (43176) to 43109 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.795), E-opt: 0.2 (0.506), width: 16
Scan time: 15.160
The best scores are: opt bits E(85289)
NP_001292473 (OMIM: 612482,617108) E3 ubiquitin-pr ( 783) 5582 513.5 1.3e-144
NP_060233 (OMIM: 612482,617108) E3 ubiquitin-prote ( 783) 5582 513.5 1.3e-144
XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 5502 506.4 2.1e-142
XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 5502 506.4 2.1e-142
NP_001292474 (OMIM: 612482,617108) E3 ubiquitin-pr ( 656) 4750 439.1 2.8e-122
XP_011523258 (OMIM: 612482,617108) PREDICTED: E3 u ( 742) 4670 432.0 4.4e-120
NP_001193927 (OMIM: 612062) E3 ubiquitin-protein l ( 936) 744 81.4 2e-14
XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 663 74.1 2.8e-12
XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 663 74.1 2.8e-12
XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 663 74.1 2.8e-12
XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 663 74.1 2.8e-12
XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 663 74.1 2.8e-12
NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 660 73.8 3.4e-12
NP_919445 (OMIM: 300439) E3 ubiquitin-protein liga ( 428) 329 44.0 0.0017
>>NP_001292473 (OMIM: 612482,617108) E3 ubiquitin-protei (783 aa)
initn: 5582 init1: 5582 opt: 5582 Z-score: 2716.9 bits: 513.5 E(85289): 1.3e-144
Smith-Waterman score: 5582; 99.9% identity (100.0% similar) in 783 aa overlap (1-783:1-783)
10 20 30 40 50 60
pF1KB6 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGMSH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
NP_001 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB6 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCE
730 740 750 760 770 780
pF1KB6 QAV
:::
NP_001 QAV
>>NP_060233 (OMIM: 612482,617108) E3 ubiquitin-protein l (783 aa)
initn: 5582 init1: 5582 opt: 5582 Z-score: 2716.9 bits: 513.5 E(85289): 1.3e-144
Smith-Waterman score: 5582; 99.9% identity (100.0% similar) in 783 aa overlap (1-783:1-783)
10 20 30 40 50 60
pF1KB6 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGMSH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
NP_060 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB6 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCE
730 740 750 760 770 780
pF1KB6 QAV
:::
NP_060 QAV
>>XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 ubiqu (869 aa)
initn: 5501 init1: 5501 opt: 5502 Z-score: 2677.7 bits: 506.4 E(85289): 2.1e-142
Smith-Waterman score: 5502; 99.5% identity (99.6% similar) in 774 aa overlap (1-774:1-774)
10 20 30 40 50 60
pF1KB6 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGMSH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_011 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB6 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCE
:::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_011 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEGSGCGR
730 740 750 760 770 780
pF1KB6 QAV
XP_011 ERRLQLNISGQVKSANKGLMEAEKDTAEMTTKILNHRDSVSCWLECRNTPPLPGATPLVG
790 800 810 820 830 840
>>XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 ubiqu (869 aa)
initn: 5501 init1: 5501 opt: 5502 Z-score: 2677.7 bits: 506.4 E(85289): 2.1e-142
Smith-Waterman score: 5502; 99.5% identity (99.6% similar) in 774 aa overlap (1-774:1-774)
10 20 30 40 50 60
pF1KB6 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGMSH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_016 PSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB6 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCE
:::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 NSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEGSGCGR
730 740 750 760 770 780
pF1KB6 QAV
XP_016 ERRLQLNISGQVKSANKGLMEAEKDTAEMTTKILNHRDSVSCWLECRNTPPLPGATPLVG
790 800 810 820 830 840
>>NP_001292474 (OMIM: 612482,617108) E3 ubiquitin-protei (656 aa)
initn: 4750 init1: 4750 opt: 4750 Z-score: 2316.2 bits: 439.1 E(85289): 2.8e-122
Smith-Waterman score: 4750; 99.8% identity (100.0% similar) in 656 aa overlap (128-783:1-656)
100 110 120 130 140 150
pF1KB6 NLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGL
::::::::::::::::::::::::::::::
NP_001 MAGERGASAVLFDITEDRAAAEQLQQPLGL
10 20 30
160 170 180 190 200 210
pF1KB6 TWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB6 LRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLE
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB6 EFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB6 RLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPR
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB6 APGEQQRLAGAQHPYAQGWGMSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGY
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_001 APGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGY
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB6 LADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDP
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB6 QRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQ
400 410 420 430 440 450
580 590 600 610 620 630
pF1KB6 SRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTS
460 470 480 490 500 510
640 650 660 670 680 690
pF1KB6 SLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAH
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB6 PLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPC
580 590 600 610 620 630
760 770 780
pF1KB6 PYPHCQVLSAQPGSEEELEELCEQAV
::::::::::::::::::::::::::
NP_001 PYPHCQVLSAQPGSEEELEELCEQAV
640 650
>>XP_011523258 (OMIM: 612482,617108) PREDICTED: E3 ubiqu (742 aa)
initn: 4669 init1: 4669 opt: 4670 Z-score: 2276.9 bits: 432.0 E(85289): 4.4e-120
Smith-Waterman score: 4670; 99.4% identity (99.5% similar) in 647 aa overlap (128-774:1-647)
100 110 120 130 140 150
pF1KB6 NLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGL
::::::::::::::::::::::::::::::
XP_011 MAGERGASAVLFDITEDRAAAEQLQQPLGL
10 20 30
160 170 180 190 200 210
pF1KB6 TWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB6 LRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLE
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB6 EFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB6 RLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPR
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB6 APGEQQRLAGAQHPYAQGWGMSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGY
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_011 APGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGY
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB6 LADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDP
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB6 QRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQ
400 410 420 430 440 450
580 590 600 610 620 630
pF1KB6 SRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTS
460 470 480 490 500 510
640 650 660 670 680 690
pF1KB6 SLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAH
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB6 PLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPC
580 590 600 610 620 630
760 770 780
pF1KB6 PYPHCQVLSAQPGSEEELEELCEQAV
::::::::::::: :
XP_011 PYPHCQVLSAQPGEFSEGSGCGRERRLQLNISGQVKSANKGLMEAEKDTAEMTTKILNHR
640 650 660 670 680 690
>>NP_001193927 (OMIM: 612062) E3 ubiquitin-protein ligas (936 aa)
initn: 873 init1: 266 opt: 744 Z-score: 379.9 bits: 81.4 E(85289): 2e-14
Smith-Waterman score: 988; 32.1% identity (54.2% similar) in 823 aa overlap (29-744:42-820)
10 20 30 40 50
pF1KB6 MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPT
::.:::: . :.. :...:. .. .:.
NP_001 TGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPS
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB6 GKLNLT---LEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
: . : : :. .. :::...: ::: ::: .:...: : :....::::.:.
NP_001 GDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
80 90 100 110 120 130
120 130 140 150 160 170
pF1KB6 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDAEKL
:.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : :: ::
NP_001 DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
140 150 160 170 180 190
180 190 200 210 220 230
pF1KB6 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
:..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:. .
NP_001 MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
200 210 220 230 240
240 250 260 270 280
pF1KB6 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.:::
NP_001 SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB6 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
:: : :.:::.:::::: ::.::: : :: : . ... : :: :. : .
NP_001 VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
310 320 330 340 350 360
350 360 370 380
pF1KB6 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
.::..: .:: : :.:... : .: :. .. : :
NP_001 YPGRVHRTNAIPA-Y---PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
370 380 390 400 410 420
390 400 410 420
pF1KB6 -------HRFP---RAAHPRAPGEQQRLAGA---------------QHPYAQGWGMSHLQ
:: :: : : .. .:.: :: : : :.:. .
NP_001 LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQ--GLSYPE
430 440 450 460 470 480
430 440 450
pF1KB6 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTERS---G
. .: : . : :: ::..::: : . : .:: :
NP_001 QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
490 500 510 520 530 540
460 470 480 490 500 510
pF1KB6 YLADGPASDSSS----GPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
:::: :.::::: : :: :::::::.::..: :::.:: ::: ::::::.::..: :
NP_001 YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
550 560 570 580 590 600
520 530 540 550 560 570
pF1KB6 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
. : :.. . : :. :. . : . : : : . : : :.
NP_001 RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
610 620 630 640 650
580 590 600 610
pF1KB6 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
.: : . .. . : .:...... : .:::. : . :.:
NP_001 PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCA-
660 670 680 690 700 710
620 630 640 650 660 670
pF1KB6 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
:: :.:. :. ..:.:: :. :. . .::. :: :: .:
NP_001 CCCEPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
720 730 740 750 760
680 690 700 710 720 730
pF1KB6 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTP
: . .:. : .: : : : . . : : . ::... : . :
NP_001 P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQYTL
770 780 790 800 810
740 750 760 770 780
pF1KB6 RQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV
. :: ::: :
NP_001 TE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH
820 830 840 850 860
>>XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 845 init1: 266 opt: 663 Z-score: 341.4 bits: 74.1 E(85289): 2.8e-12
Smith-Waterman score: 907; 32.0% identity (53.4% similar) in 766 aa overlap (83-744:4-725)
60 70 80 90 100 110
pF1KB6 LKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLES
.. ::: ::: .:...: : :....::::.
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQ
10 20 30
120 130 140 150 160
pF1KB6 PRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDA
:. :.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : ::
XP_011 PELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADA
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 EKLMEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHS
:::..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:
XP_011 IKLMNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB6 RPDPLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQ
. . ... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.
XP_011 Q-NSMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGE
160 170 180 190 200
290 300 310 320 330 340
pF1KB6 ELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHL
::::: : :.:::.:::::: ::.::: : :: : . ... : :: :. :
XP_011 ELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTL
210 220 230 240 250 260
350 360 370 380
pF1KB6 IRQHPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMG
..::..: .:: : :.:... : .: :. ..
XP_011 PVHYPGRVHRTNAIPA-Y---PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYP
270 280 290 300 310 320
390 400 410
pF1KB6 PRH-------HRFP---RAAHPRAPGEQQRLAGA---------------QHPYAQGWGMS
: : :: :: : : .. .:.: :: : :: .:
XP_011 PLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LS
330 340 350 360 370 380
420 430 440 450
pF1KB6 HLQSTSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTERS-
. .. .: : . : :: ::..::: : . : .::
XP_011 YPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSV
390 400 410 420 430 440
460 470 480 490 500
pF1KB6 --GYLADGPASDSSS----GPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLV
::::: :.::::: : :: :::::::.::..: :::.:: ::: ::::::.::..
XP_011 CSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFI
450 460 470 480 490 500
510 520 530 540 550 560
pF1KB6 YCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRK
: : .: :.. . : :. :. . : . : : : . : :
XP_011 YRSR--SPCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--
510 520 530 540 550
570 580 590 600 610
pF1KB6 PGPETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQ
:. .: : . .. . : .:...... : .:::. : . :.
XP_011 PASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPS
560 570 580 590 600 610
620 630 640 650 660 670
pF1KB6 CPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDA
: :: :.:. :. ..:.:: :. . .::. :: ::
XP_011 CACCC-EPQPSPAGPSAGAAGSSTLF---------LGPHLYEGSGPAGGEPQSGSSQGLY
620 630 640 650 660
680 690 700 710 720
pF1KB6 TVHPACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLC
.:: . .:. : .: : : : . . : : . ::... : .
XP_011 GLHP--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQ
670 680 690 700 710
730 740 750 760 770 780
pF1KB6 LTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV
: . :: ::: :
XP_011 YTLTE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTP
720 730 740 750 760
>>XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 845 init1: 266 opt: 663 Z-score: 341.4 bits: 74.1 E(85289): 2.8e-12
Smith-Waterman score: 907; 32.0% identity (53.4% similar) in 766 aa overlap (83-744:4-725)
60 70 80 90 100 110
pF1KB6 LKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLES
.. ::: ::: .:...: : :....::::.
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQ
10 20 30
120 130 140 150 160
pF1KB6 PRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDA
:. :.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : ::
XP_011 PELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADA
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 EKLMEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHS
:::..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:
XP_011 IKLMNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB6 RPDPLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQ
. . ... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.
XP_011 Q-NSMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGE
160 170 180 190 200
290 300 310 320 330 340
pF1KB6 ELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHL
::::: : :.:::.:::::: ::.::: : :: : . ... : :: :. :
XP_011 ELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTL
210 220 230 240 250 260
350 360 370 380
pF1KB6 IRQHPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMG
..::..: .:: : :.:... : .: :. ..
XP_011 PVHYPGRVHRTNAIPA-Y---PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYP
270 280 290 300 310 320
390 400 410
pF1KB6 PRH-------HRFP---RAAHPRAPGEQQRLAGA---------------QHPYAQGWGMS
: : :: :: : : .. .:.: :: : :: .:
XP_011 PLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LS
330 340 350 360 370 380
420 430 440 450
pF1KB6 HLQSTSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTERS-
. .. .: : . : :: ::..::: : . : .::
XP_011 YPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSV
390 400 410 420 430 440
460 470 480 490 500
pF1KB6 --GYLADGPASDSSS----GPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLV
::::: :.::::: : :: :::::::.::..: :::.:: ::: ::::::.::..
XP_011 CSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFI
450 460 470 480 490 500
510 520 530 540 550 560
pF1KB6 YCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRK
: : .: :.. . : :. :. . : . : : : . : :
XP_011 YRSR--SPCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--
510 520 530 540 550
570 580 590 600 610
pF1KB6 PGPETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQ
:. .: : . .. . : .:...... : .:::. : . :.
XP_011 PASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPS
560 570 580 590 600 610
620 630 640 650 660 670
pF1KB6 CPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDA
: :: :.:. :. ..:.:: :. . .::. :: ::
XP_011 CACCC-EPQPSPAGPSAGAAGSSTLF---------LGPHLYEGSGPAGGEPQSGSSQGLY
620 630 640 650 660
680 690 700 710 720
pF1KB6 TVHPACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLC
.:: . .:. : .: : : : . . : : . ::... : .
XP_011 GLHP--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQ
670 680 690 700 710
730 740 750 760 770 780
pF1KB6 LTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV
: . :: ::: :
XP_011 YTLTE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTP
720 730 740 750 760
>>XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 845 init1: 266 opt: 663 Z-score: 341.4 bits: 74.1 E(85289): 2.8e-12
Smith-Waterman score: 907; 32.0% identity (53.4% similar) in 766 aa overlap (83-744:4-725)
60 70 80 90 100 110
pF1KB6 LKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLES
.. ::: ::: .:...: : :....::::.
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQ
10 20 30
120 130 140 150 160
pF1KB6 PRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDA
:. :.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : ::
XP_011 PELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADA
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 EKLMEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHS
:::..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:
XP_011 IKLMNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB6 RPDPLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQ
. . ... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.
XP_011 Q-NSMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGE
160 170 180 190 200
290 300 310 320 330 340
pF1KB6 ELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHL
::::: : :.:::.:::::: ::.::: : :: : . ... : :: :. :
XP_011 ELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTL
210 220 230 240 250 260
350 360 370 380
pF1KB6 IRQHPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMG
..::..: .:: : :.:... : .: :. ..
XP_011 PVHYPGRVHRTNAIPA-Y---PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYP
270 280 290 300 310 320
390 400 410
pF1KB6 PRH-------HRFP---RAAHPRAPGEQQRLAGA---------------QHPYAQGWGMS
: : :: :: : : .. .:.: :: : :: .:
XP_011 PLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LS
330 340 350 360 370 380
420 430 440 450
pF1KB6 HLQSTSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTERS-
. .. .: : . : :: ::..::: : . : .::
XP_011 YPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSV
390 400 410 420 430 440
460 470 480 490 500
pF1KB6 --GYLADGPASDSSS----GPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLV
::::: :.::::: : :: :::::::.::..: :::.:: ::: ::::::.::..
XP_011 CSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFI
450 460 470 480 490 500
510 520 530 540 550 560
pF1KB6 YCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRK
: : .: :.. . : :. :. . : . : : : . : :
XP_011 YRSR--SPCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--
510 520 530 540 550
570 580 590 600 610
pF1KB6 PGPETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQ
:. .: : . .. . : .:...... : .:::. : . :.
XP_011 PASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPS
560 570 580 590 600 610
620 630 640 650 660 670
pF1KB6 CPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDA
: :: :.:. :. ..:.:: :. . .::. :: ::
XP_011 CACCC-EPQPSPAGPSAGAAGSSTLF---------LGPHLYEGSGPAGGEPQSGSSQGLY
620 630 640 650 660
680 690 700 710 720
pF1KB6 TVHPACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLC
.:: . .:. : .: : : : . . : : . ::... : .
XP_011 GLHP--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQ
670 680 690 700 710
730 740 750 760 770 780
pF1KB6 LTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV
: . :: ::: :
XP_011 YTLTE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTP
720 730 740 750 760
783 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 14:32:05 2016 done: Sat Nov 5 14:32:08 2016
Total Scan time: 15.160 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]