Result of FASTA (omim) for
pF1KB6127
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6127, 587 aa
1>>>pF1KB6127 587 - 587 aa - 587 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1304+/-0.000424; mu= 15.9378+/- 0.026
mean_var=162.1214+/-36.008, 0's: 0 Z-trim(116.5): 767 B-trim: 1462 in 2/54
Lambda= 0.100729
statistics sampled from 26707 (27692) to 26707 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.325), width: 16
Scan time: 9.320
The best scores are: opt bits E(85289)
NP_057234 (OMIM: 605759) ankyrin repeat and SOCS b ( 587) 3914 581.6 2.4e-165
NP_001189358 (OMIM: 605759) ankyrin repeat and SOC ( 635) 3778 561.9 2.2e-159
XP_005267815 (OMIM: 605759) PREDICTED: ankyrin rep ( 635) 3778 561.9 2.2e-159
XP_011535137 (OMIM: 605759) PREDICTED: ankyrin rep ( 533) 3545 528.0 3.1e-149
XP_016876858 (OMIM: 605759) PREDICTED: ankyrin rep ( 600) 3544 527.9 3.7e-149
XP_011535136 (OMIM: 605759) PREDICTED: ankyrin rep ( 583) 2835 424.8 3.8e-118
NP_057199 (OMIM: 605760) ankyrin repeat and SOCS b ( 518) 638 105.5 4.5e-22
XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 559 94.7 2.7e-18
XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 559 94.7 2.8e-18
XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 559 94.7 2.8e-18
XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 559 94.7 2.8e-18
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 559 94.7 2.8e-18
XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 559 94.7 2.8e-18
XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 559 94.7 2.8e-18
XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 559 94.7 2.8e-18
XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 559 94.7 2.8e-18
XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 559 94.7 2.8e-18
NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 559 94.7 2.8e-18
XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871) 559 94.7 2.9e-18
XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 559 94.7 2.9e-18
NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 559 94.7 2.9e-18
XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 559 94.7 2.9e-18
XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 559 94.7 2.9e-18
XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 559 94.7 2.9e-18
XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 559 94.7 2.9e-18
XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893) 559 94.7 2.9e-18
XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 559 94.7 2.9e-18
XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 559 94.7 2.9e-18
XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 559 94.7 2.9e-18
XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 559 94.7 2.9e-18
XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 559 94.7 2.9e-18
XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 559 94.7 2.9e-18
XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931) 559 94.7 2.9e-18
XP_016863569 (OMIM: 106410,600919) PREDICTED: anky (1970) 559 94.8 2.9e-18
XP_016863568 (OMIM: 106410,600919) PREDICTED: anky (2006) 559 94.8 3e-18
XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020) 559 94.8 3e-18
NP_001139 (OMIM: 106410,600919) ankyrin-2 isoform (3957) 559 95.1 4.5e-18
XP_005263002 (OMIM: 106410,600919) PREDICTED: anky (4072) 559 95.2 4.6e-18
XP_016863566 (OMIM: 106410,600919) PREDICTED: anky (4074) 559 95.2 4.6e-18
XP_016863565 (OMIM: 106410,600919) PREDICTED: anky (4105) 559 95.2 4.6e-18
XP_016863564 (OMIM: 106410,600919) PREDICTED: anky (4115) 559 95.2 4.6e-18
XP_016863563 (OMIM: 106410,600919) PREDICTED: anky (4127) 559 95.2 4.7e-18
XP_016863562 (OMIM: 106410,600919) PREDICTED: anky (4136) 559 95.2 4.7e-18
XP_016863561 (OMIM: 106410,600919) PREDICTED: anky (4137) 559 95.2 4.7e-18
XP_016863560 (OMIM: 106410,600919) PREDICTED: anky (4145) 559 95.2 4.7e-18
XP_016863559 (OMIM: 106410,600919) PREDICTED: anky (4163) 559 95.2 4.7e-18
XP_016863558 (OMIM: 106410,600919) PREDICTED: anky (4175) 559 95.2 4.7e-18
XP_016863557 (OMIM: 106410,600919) PREDICTED: anky (4181) 559 95.2 4.7e-18
XP_016863556 (OMIM: 106410,600919) PREDICTED: anky (4183) 559 95.2 4.7e-18
XP_016863601 (OMIM: 106410,600919) PREDICTED: anky (1689) 546 92.8 9.9e-18
>>NP_057234 (OMIM: 605759) ankyrin repeat and SOCS box p (587 aa)
initn: 3914 init1: 3914 opt: 3914 Z-score: 3089.5 bits: 581.6 E(85289): 2.4e-165
Smith-Waterman score: 3914; 100.0% identity (100.0% similar) in 587 aa overlap (1-587:1-587)
10 20 30 40 50 60
pF1KB6 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 NYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 NYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 DRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 AYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 PAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKE
490 500 510 520 530 540
550 560 570 580
pF1KB6 KAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
:::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
550 560 570 580
>>NP_001189358 (OMIM: 605759) ankyrin repeat and SOCS bo (635 aa)
initn: 3778 init1: 3778 opt: 3778 Z-score: 2982.3 bits: 561.9 E(85289): 2.2e-159
Smith-Waterman score: 3778; 99.8% identity (100.0% similar) in 568 aa overlap (20-587:68-635)
10 20 30 40
pF1KB6 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSL
.:::::::::::::::::::::::::::::
NP_001 SLADKTRGPTTAEATASACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB6 FKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KB6 QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKN
160 170 180 190 200 210
170 180 190 200 210 220
pF1KB6 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV
220 230 240 250 260 270
230 240 250 260 270 280
pF1KB6 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG
280 290 300 310 320 330
290 300 310 320 330 340
pF1KB6 LLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT
340 350 360 370 380 390
350 360 370 380 390 400
pF1KB6 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTM
400 410 420 430 440 450
410 420 430 440 450 460
pF1KB6 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP
460 470 480 490 500 510
470 480 490 500 510 520
pF1KB6 APQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHI
520 530 540 550 560 570
530 540 550 560 570 580
pF1KB6 DSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
580 590 600 610 620 630
>>XP_005267815 (OMIM: 605759) PREDICTED: ankyrin repeat (635 aa)
initn: 3778 init1: 3778 opt: 3778 Z-score: 2982.3 bits: 561.9 E(85289): 2.2e-159
Smith-Waterman score: 3778; 99.8% identity (100.0% similar) in 568 aa overlap (20-587:68-635)
10 20 30 40
pF1KB6 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSL
.:::::::::::::::::::::::::::::
XP_005 SLADKTRGPTTAEATASACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB6 FKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KB6 QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKN
160 170 180 190 200 210
170 180 190 200 210 220
pF1KB6 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV
220 230 240 250 260 270
230 240 250 260 270 280
pF1KB6 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG
280 290 300 310 320 330
290 300 310 320 330 340
pF1KB6 LLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT
340 350 360 370 380 390
350 360 370 380 390 400
pF1KB6 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTM
400 410 420 430 440 450
410 420 430 440 450 460
pF1KB6 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP
460 470 480 490 500 510
470 480 490 500 510 520
pF1KB6 APQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHI
520 530 540 550 560 570
530 540 550 560 570 580
pF1KB6 DSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
580 590 600 610 620 630
>>XP_011535137 (OMIM: 605759) PREDICTED: ankyrin repeat (533 aa)
initn: 3545 init1: 3545 opt: 3545 Z-score: 2800.2 bits: 528.0 E(85289): 3.1e-149
Smith-Waterman score: 3545; 99.6% identity (99.8% similar) in 533 aa overlap (55-587:1-533)
30 40 50 60 70 80
pF1KB6 PPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLA
. ::::::::::::::::::::::::::::
XP_011 MRPADPLIKAIKDGDEEALKTMIKEGKNLA
10 20 30
90 100 110 120 130 140
pF1KB6 EPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 QAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLE
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 VMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEAC
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB6 KNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB6 LHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQ
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB6 HGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLL
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB6 KFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRW
400 410 420 430 440 450
510 520 530 540 550 560
pF1KB6 AGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYR
460 470 480 490 500 510
570 580
pF1KB6 IKLLDTLPLPGRLIRYLKYENTQ
:::::::::::::::::::::::
XP_011 IKLLDTLPLPGRLIRYLKYENTQ
520 530
>>XP_016876858 (OMIM: 605759) PREDICTED: ankyrin repeat (600 aa)
initn: 3544 init1: 3544 opt: 3544 Z-score: 2798.8 bits: 527.9 E(85289): 3.7e-149
Smith-Waterman score: 3544; 100.0% identity (100.0% similar) in 531 aa overlap (57-587:70-600)
30 40 50 60 70 80
pF1KB6 ESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEP
::::::::::::::::::::::::::::::
XP_016 ADKTRGPTTAEATASACTNRQPAHFYPWTRPADPLIKAIKDGDEEALKTMIKEGKNLAEP
40 50 60 70 80 90
90 100 110 120 130 140
pF1KB6 NKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQA
100 110 120 130 140 150
150 160 170 180 190 200
pF1KB6 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM
160 170 180 190 200 210
210 220 230 240 250 260
pF1KB6 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKN
220 230 240 250 260 270
270 280 290 300 310 320
pF1KB6 EHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLH
280 290 300 310 320 330
330 340 350 360 370 380
pF1KB6 LAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB6 ADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKF
400 410 420 430 440 450
450 460 470 480 490 500
pF1KB6 LMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAG
460 470 480 490 500 510
510 520 530 540 550 560
pF1KB6 PIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK
520 530 540 550 560 570
570 580
pF1KB6 LLDTLPLPGRLIRYLKYENTQ
:::::::::::::::::::::
XP_016 LLDTLPLPGRLIRYLKYENTQ
580 590 600
>>XP_011535136 (OMIM: 605759) PREDICTED: ankyrin repeat (583 aa)
initn: 2835 init1: 2835 opt: 2835 Z-score: 2242.1 bits: 424.8 E(85289): 3.8e-118
Smith-Waterman score: 3321; 90.7% identity (90.8% similar) in 568 aa overlap (20-587:68-583)
10 20 30 40
pF1KB6 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSL
.:::::::::::::::::::::::::::::
XP_011 SLADKTRGPTTAEATASACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB6 FKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KB6 QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKN
::: :::::
XP_011 QRA----------------------------------------------------CERKN
160
170 180 190 200 210 220
pF1KB6 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB6 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB6 LLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB6 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTM
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB6 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP
410 420 430 440 450 460
470 480 490 500 510 520
pF1KB6 APQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHI
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB6 DSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
530 540 550 560 570 580
>>NP_057199 (OMIM: 605760) ankyrin repeat and SOCS box p (518 aa)
initn: 533 init1: 281 opt: 638 Z-score: 517.2 bits: 105.5 E(85289): 4.5e-22
Smith-Waterman score: 684; 29.0% identity (60.9% similar) in 545 aa overlap (64-585:17-502)
40 50 60 70 80 90
pF1KB6 PMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLP
: ..:. ..:. ..:.:... ...::.:
NP_057 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMP
10 20 30 40
100 110 120 130 140 150
pF1KB6 LHEAAYYGQVGCLKVLQRAYPGT--IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD
.:::::...: ::..: : . : ..:.. :..::. .:: . ::.:::.:.
NP_057 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN
50 60 70 80 90 100
160 170 180 190 200
pF1KB6 ISNKSRETPLYKACERKNAEAVKILVQHNADTN--HR-CNRGWTALHESVSRNDLEVMQI
.. . :::. : : . .....:.::.:..: : : ::..::.. ... :....
NP_057 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKL
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB6 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
:. ::. : .. .:::::::::: :.::.: .: . ::..: :: :.:. :. : .. :
NP_057 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB6 EEVVEFLLSQGADAN-KTNKDGL-LPLHIASKKGNYRIVQMLLPVTSRT-RIRRSGVSPL
. ::.:::.::: . :.:. ::.: :.. :. .:...:.:.:.:. . :::.
NP_057 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB6 HLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQH
. :. .:.. :: :: . .: : .. : :.
NP_057 YSAVFGGHEDCLEILLRNGY---SPDA-----------QACLVFGFS-------------
290 300 310
390 400 410 420 430 440
pF1KB6 GADPNRDVISPLLVAIRHGC--LRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSL
::. .:... : . ...:: .::.:. : :. . .. .:.
NP_057 ---------SPVCMAFQKDCEFFGIVNILLKYGAQINEL---H-LAY----CLKYEKFSI
320 330 340 350 360
450 460 470 480 490
pF1KB6 LKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFND-AP---AADKEPSVVQFCEFVSAP
..... ::. : .. .: : : . ...... : .: .: .. .:
NP_057 FRYFLRKGCSLGP-WNHIYEFVNH--AIKAQAKYKEWLPHLLVAGFDP-LILLC------
370 380 390 400 410
500 510 520 530 540 550
pF1KB6 EVSRWAGPI-IDVL---LDYVGNVQLCSRLKEHIDSFED--WAVIKEKAEPPRPLAHLCR
. : . ::.: :.... : ... ... . : . .. : : :.::::
NP_057 --NSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPS-LTHLCR
420 430 440 450 460
560 570 580
pF1KB6 LRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
:..:... . :.. .. :::: : :: ::.
NP_057 LEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
470 480 490 500 510
>>XP_016863600 (OMIM: 106410,600919) PREDICTED: ankyrin- (1755 aa)
initn: 346 init1: 346 opt: 559 Z-score: 449.3 bits: 94.7 E(85289): 2.7e-18
Smith-Waterman score: 559; 29.4% identity (66.5% similar) in 367 aa overlap (60-421:372-727)
30 40 50 60 70 80
pF1KB6 PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE
:: : : . .... ..: : .. ..
XP_016 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES
350 360 370 380 390 400
90 100 110 120 130 140
pF1KB6 GWLPLHEAAYYGQVG-CLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA
: :.: ::..:... : .:: . .. : ... :::...:. :... . ::. ::
XP_016 GLTPIHVAAFMGHLNIVLLLLQNG--ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA
410 420 430 440 450
150 160 170 180 190 200
pF1KB6 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI
: . ..:::. : . ..: :..:.:: : . . :.: :: :. .....: ..
XP_016 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV
460 470 480 490 500 510
210 220 230 240 250 260
pF1KB6 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
:. .:: . :.::: :::. :.:.. ..: . : .. .... . :. : . ..
XP_016 LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN
520 530 540 550 560 570
270 280 290 300 310 320
pF1KB6 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHL
..:. .:: .::. . : :.: :::::.::....:.. :: ..: : ..::.::::
XP_016 QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL
580 590 600 610 620 630
330 340 350 360 370 380
pF1KB6 AAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA
:....: ... ::. ... .. : ..:..:. ...: ....: .:::
XP_016 ASQEGHTDMVTLLLDKGANIHM---STKSGL------TSLHLAAQEDKVNVADILTKHGA
640 650 660 670 680 690
390 400 410 420 430 440
pF1KB6 DPNRDV---ISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLL
: . . .::.:: ..: .. ...:: .:::..:
XP_016 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV
700 710 720 730 740 750
450 460 470 480 490 500
pF1KB6 KFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRW
XP_016 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETM
760 770 780 790 800 810
>--
initn: 304 init1: 304 opt: 354 Z-score: 288.3 bits: 64.9 E(85289): 2.5e-09
Smith-Waterman score: 462; 28.4% identity (62.8% similar) in 363 aa overlap (63-421:16-364)
40 50 60 70 80 90
pF1KB6 APMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWL
.: . :. . . ..: : .. :..:
XP_016 MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLN
10 20 30 40
100 110 120 130 140 150
pF1KB6 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI
:: :: :.:: .. : . ...:. : . .::...:. :. . . :.. ::. .
XP_016 ALHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA
50 60 70 80 90 100
160 170 180 190 200 210
pF1KB6 SNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG
.... :::: : .... ..:: :....:. . . :.: : ..... ... ::. .
XP_016 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB6 GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVV
..:. . : .::.. . .. .: . . ..:.... . :. : . . .:.
XP_016 ----DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVA
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB6 EFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAER
.::..:: .. : ..:. :::.:::.:: .:..:: .. . :.:..::: ::.
XP_016 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS
230 240 250 260 270 280
340 350 360 370 380
pF1KB6 NHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---D
.::.:.: :: :: :: . : :..:. ...: .. :::: : :
XP_016 GHDQVVELLLERG-------APLLARTKNGL--SPLHMAAQGDHVECVKHLLQHKAPVDD
290 300 310 320 330
390 400 410 420 430 440
pF1KB6 PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLM
. : .. : :: . : :. .::::. :: .:
XP_016 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB6 DLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPI
XP_016 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV
400 410 420 430 440 450
>>XP_016863599 (OMIM: 106410,600919) PREDICTED: ankyrin- (1763 aa)
initn: 346 init1: 346 opt: 559 Z-score: 449.3 bits: 94.7 E(85289): 2.8e-18
Smith-Waterman score: 559; 29.4% identity (66.5% similar) in 367 aa overlap (60-421:380-735)
30 40 50 60 70 80
pF1KB6 PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE
:: : : . .... ..: : .. ..
XP_016 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES
350 360 370 380 390 400
90 100 110 120 130 140
pF1KB6 GWLPLHEAAYYGQVG-CLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA
: :.: ::..:... : .:: . .. : ... :::...:. :... . ::. ::
XP_016 GLTPIHVAAFMGHLNIVLLLLQNG--ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA
410 420 430 440 450 460
150 160 170 180 190 200
pF1KB6 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI
: . ..:::. : . ..: :..:.:: : . . :.: :: :. .....: ..
XP_016 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV
470 480 490 500 510 520
210 220 230 240 250 260
pF1KB6 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
:. .:: . :.::: :::. :.:.. ..: . : .. .... . :. : . ..
XP_016 LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN
530 540 550 560 570 580
270 280 290 300 310 320
pF1KB6 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHL
..:. .:: .::. . : :.: :::::.::....:.. :: ..: : ..::.::::
XP_016 QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL
590 600 610 620 630 640
330 340 350 360 370 380
pF1KB6 AAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA
:....: ... ::. ... .. : ..:..:. ...: ....: .:::
XP_016 ASQEGHTDMVTLLLDKGANIHM---STKSGL------TSLHLAAQEDKVNVADILTKHGA
650 660 670 680 690
390 400 410 420 430 440
pF1KB6 DPNRDV---ISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLL
: . . .::.:: ..: .. ...:: .:::..:
XP_016 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV
700 710 720 730 740 750
450 460 470 480 490 500
pF1KB6 KFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRW
XP_016 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETM
760 770 780 790 800 810
>--
initn: 348 init1: 274 opt: 329 Z-score: 268.7 bits: 61.3 E(85289): 3.2e-08
Smith-Waterman score: 433; 29.1% identity (61.9% similar) in 357 aa overlap (77-421:30-372)
50 60 70 80 90 100
pF1KB6 SSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCL
.: : .. :..: :: :: :.:: .
XP_016 MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLV
10 20 30 40 50
110 120 130 140 150 160
pF1KB6 KVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACE
. : . ...:. : . .::...:. :. . . :.. ::. . .... :::: : .
XP_016 QELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ
60 70 80 90 100 110
170 180 190 200 210 220
pF1KB6 RKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITP
... ..:: :....:. . . :.: : ..... ... ::. . ..:. .
XP_016 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPA
120 130 140 150 160 170
230 240 250 260 270
pF1KB6 LFVAAQSGQLE--ALRFLAKYGADINTQASDNASA------LYEACKNEHEEVVEFLLSQ
: .::.. . . :: . ..::.... : .. :. : . . .:. .::..
XP_016 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR
180 190 200 210 220 230
280 290 300 310 320 330
pF1KB6 GADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVL
:: .. : ..:. :::.:::.:: .:..:: .. . :.:..::: ::. .::.:.
XP_016 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV
240 250 260 270 280 290
340 350 360 370 380 390
pF1KB6 EALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVI
: :: :: :: . : :..:. ...: .. :::: : : . : .
XP_016 ELLLERG-------APLLARTKNG--LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL
300 310 320 330 340
400 410 420 430 440 450
pF1KB6 SPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDG
. : :: . : :. .::::. :: .:
XP_016 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA
350 360 370 380 390 400
>>XP_016863598 (OMIM: 106410,600919) PREDICTED: ankyrin- (1770 aa)
initn: 346 init1: 346 opt: 559 Z-score: 449.3 bits: 94.7 E(85289): 2.8e-18
Smith-Waterman score: 559; 29.4% identity (66.5% similar) in 367 aa overlap (60-421:372-727)
30 40 50 60 70 80
pF1KB6 PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE
:: : : . .... ..: : .. ..
XP_016 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES
350 360 370 380 390 400
90 100 110 120 130 140
pF1KB6 GWLPLHEAAYYGQVG-CLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA
: :.: ::..:... : .:: . .. : ... :::...:. :... . ::. ::
XP_016 GLTPIHVAAFMGHLNIVLLLLQNG--ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA
410 420 430 440 450
150 160 170 180 190 200
pF1KB6 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI
: . ..:::. : . ..: :..:.:: : . . :.: :: :. .....: ..
XP_016 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV
460 470 480 490 500 510
210 220 230 240 250 260
pF1KB6 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH
:. .:: . :.::: :::. :.:.. ..: . : .. .... . :. : . ..
XP_016 LLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN
520 530 540 550 560 570
270 280 290 300 310 320
pF1KB6 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHL
..:. .:: .::. . : :.: :::::.::....:.. :: ..: : ..::.::::
XP_016 QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL
580 590 600 610 620 630
330 340 350 360 370 380
pF1KB6 AAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA
:....: ... ::. ... .. : ..:..:. ...: ....: .:::
XP_016 ASQEGHTDMVTLLLDKGANIHM---STKSGL------TSLHLAAQEDKVNVADILTKHGA
640 650 660 670 680 690
390 400 410 420 430 440
pF1KB6 DPNRDV---ISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLL
: . . .::.:: ..: .. ...:: .:::..:
XP_016 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV
700 710 720 730 740 750
450 460 470 480 490 500
pF1KB6 KFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRW
XP_016 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETM
760 770 780 790 800 810
>--
initn: 304 init1: 304 opt: 354 Z-score: 288.3 bits: 64.9 E(85289): 2.6e-09
Smith-Waterman score: 462; 28.4% identity (62.8% similar) in 363 aa overlap (63-421:16-364)
40 50 60 70 80 90
pF1KB6 APMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWL
.: . :. . . ..: : .. :..:
XP_016 MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLN
10 20 30 40
100 110 120 130 140 150
pF1KB6 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI
:: :: :.:: .. : . ...:. : . .::...:. :. . . :.. ::. .
XP_016 ALHLAAKEGHVGLVQELL-GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA
50 60 70 80 90 100
160 170 180 190 200 210
pF1KB6 SNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG
.... :::: : .... ..:: :....:. . . :.: : ..... ... ::. .
XP_016 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB6 GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVV
..:. . : .::.. . .. .: . . ..:.... . :. : . . .:.
XP_016 ----DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVA
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB6 EFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAER
.::..:: .. : ..:. :::.:::.:: .:..:: .. . :.:..::: ::.
XP_016 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS
230 240 250 260 270 280
340 350 360 370 380
pF1KB6 NHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---D
.::.:.: :: :: :: . : :..:. ...: .. :::: : :
XP_016 GHDQVVELLLERG-------APLLARTKNGL--SPLHMAAQGDHVECVKHLLQHKAPVDD
290 300 310 320 330
390 400 410 420 430 440
pF1KB6 PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLM
. : .. : :: . : :. .::::. :: .:
XP_016 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB6 DLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPI
XP_016 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV
400 410 420 430 440 450
587 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:00:05 2016 done: Sat Nov 5 11:00:07 2016
Total Scan time: 9.320 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]