Result of FASTA (omim) for
pF1KB4571
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4571, 615 aa
1>>>pF1KB4571 615 - 615 aa - 615 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2396+/-0.000406; mu= 9.8719+/- 0.025
mean_var=131.7426+/-26.365, 0's: 0 Z-trim(115.5): 36 B-trim: 14 in 1/56
Lambda= 0.111741
statistics sampled from 25972 (26007) to 25972 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.305), width: 16
Scan time: 9.150
The best scores are: opt bits E(85289)
NP_002287 (OMIM: 169400,215140,600024,613471) lami ( 615) 4128 677.5 3.8e-194
NP_919424 (OMIM: 169400,215140,600024,613471) lami ( 615) 4128 677.5 3.8e-194
XP_011542487 (OMIM: 169400,215140,600024,613471) P ( 615) 4128 677.5 3.8e-194
XP_005273182 (OMIM: 169400,215140,600024,613471) P ( 573) 2623 434.8 3.8e-121
NP_003264 (OMIM: 603414) delta(14)-sterol reductas ( 418) 1676 282.1 2.7e-75
NP_001264162 (OMIM: 603414) delta(14)-sterol reduc ( 391) 551 100.7 1e-20
XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-de ( 456) 430 81.2 8.5e-15
NP_001351 (OMIM: 270400,602858) 7-dehydrocholester ( 475) 425 80.4 1.5e-14
NP_001157289 (OMIM: 270400,602858) 7-dehydrocholes ( 475) 425 80.4 1.5e-14
>>NP_002287 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa)
initn: 4128 init1: 4128 opt: 4128 Z-score: 3606.6 bits: 677.5 E(85289): 3.8e-194
Smith-Waterman score: 4128; 99.8% identity (100.0% similar) in 615 aa overlap (1-615:1-615)
10 20 30 40 50 60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_002 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
550 560 570 580 590 600
610
pF1KB4 KYCQRVPYRIFPYIY
:::::::::::::::
NP_002 KYCQRVPYRIFPYIY
610
>>NP_919424 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa)
initn: 4128 init1: 4128 opt: 4128 Z-score: 3606.6 bits: 677.5 E(85289): 3.8e-194
Smith-Waterman score: 4128; 99.8% identity (100.0% similar) in 615 aa overlap (1-615:1-615)
10 20 30 40 50 60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_919 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
550 560 570 580 590 600
610
pF1KB4 KYCQRVPYRIFPYIY
:::::::::::::::
NP_919 KYCQRVPYRIFPYIY
610
>>XP_011542487 (OMIM: 169400,215140,600024,613471) PREDI (615 aa)
initn: 4128 init1: 4128 opt: 4128 Z-score: 3606.6 bits: 677.5 E(85289): 3.8e-194
Smith-Waterman score: 4128; 99.8% identity (100.0% similar) in 615 aa overlap (1-615:1-615)
10 20 30 40 50 60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
550 560 570 580 590 600
610
pF1KB4 KYCQRVPYRIFPYIY
:::::::::::::::
XP_011 KYCQRVPYRIFPYIY
610
>>XP_005273182 (OMIM: 169400,215140,600024,613471) PREDI (573 aa)
initn: 3856 init1: 2615 opt: 2623 Z-score: 2295.9 bits: 434.8 E(85289): 3.8e-121
Smith-Waterman score: 3776; 93.0% identity (93.2% similar) in 615 aa overlap (1-615:1-573)
10 20 30 40 50 60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_005 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
::::::::::::::::::::::::::::::::::::
XP_005 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGW------------------------
370 380 390
430 440 450 460 470 480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
::::::::::::::::::::::::::::::::::::::::::
XP_005 ------------------EALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
400 410 420 430
490 500 510 520 530 540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
500 510 520 530 540 550
610
pF1KB4 KYCQRVPYRIFPYIY
:::::::::::::::
XP_005 KYCQRVPYRIFPYIY
560 570
>>NP_003264 (OMIM: 603414) delta(14)-sterol reductase is (418 aa)
initn: 1419 init1: 1081 opt: 1676 Z-score: 1472.8 bits: 282.1 E(85289): 2.7e-75
Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (207-615:11-418)
180 190 200 210 220 230
pF1KB4 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
::::: :. ... ::. .: ::: ..
NP_003 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
10 20 30 40
240 250 260 270 280 290
pF1KB4 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: .
NP_003 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
50 60 70 80 90 100
300 310 320 330 340 350
pF1KB4 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . :
NP_003 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
110 120 130 140 150 160
360 370 380 390 400 410
pF1KB4 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
.:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :.
NP_003 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
170 180 190 200 210
420 430 440 450 460 470
pF1KB4 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
NP_003 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
220 230 240 250 260 270
480 490 500 510 520 530
pF1KB4 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
. ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..::
NP_003 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL
280 290 300 310 320 330
540 550 560 570 580 590
pF1KB4 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
NP_003 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
340 350 360 370 380 390
600 610
pF1KB4 GVAWEKYCQRVPYRIFPYIY
:.::..::.::::::.::::
NP_003 GLAWQEYCRRVPYRIMPYIY
400 410
>>NP_001264162 (OMIM: 603414) delta(14)-sterol reductase (391 aa)
initn: 1255 init1: 551 opt: 551 Z-score: 493.1 bits: 100.7 E(85289): 1e-20
Smith-Waterman score: 1468; 54.4% identity (75.4% similar) in 410 aa overlap (207-615:11-391)
180 190 200 210 220 230
pF1KB4 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
::::: :. ... ::. .: ::: ..
NP_001 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
10 20 30 40
240 250 260 270 280 290
pF1KB4 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: .
NP_001 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
50 60 70 80 90 100
300 310 320 330 340 350
pF1KB4 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . :
NP_001 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
110 120 130 140 150 160
360 370 380 390 400 410
pF1KB4 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
.:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :.
NP_001 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
170 180 190 200 210
420 430 440 450 460 470
pF1KB4 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
NP_001 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
220 230 240 250 260 270
480 490 500 510 520 530
pF1KB4 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
. ::. .. ::::.: : .. : :.:: :.::..::
NP_001 LHHPQPLGLPMASVI-----C---LING-------------------LETISTATGRKLL
280 290 300 310
540 550 560 570 580 590
pF1KB4 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
NP_001 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
320 330 340 350 360 370
600 610
pF1KB4 GVAWEKYCQRVPYRIFPYIY
:.::..::.::::::.::::
NP_001 GLAWQEYCRRVPYRIMPYIY
380 390
>>XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-dehydr (456 aa)
initn: 406 init1: 215 opt: 430 Z-score: 386.7 bits: 81.2 E(85289): 8.5e-15
Smith-Waterman score: 453; 28.9% identity (62.2% similar) in 294 aa overlap (203-471:31-321)
180 190 200 210 220 230
pF1KB4 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
:: ... :. . .::..:. : ... ...
XP_011 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
10 20 30 40 50
240 250 260 270
pF1KB4 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
: : . .: ... : ..: .. .: :: .:::.:
XP_011 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
60 70 80 90 100 110
280 290 300 310 320
pF1KB4 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
.:: .: . ::. : ::..::. :..:: . .. :.. ......
XP_011 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
120 130 140 150 160 170
330 340 350 360 370 380
pF1KB4 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
XP_011 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
180 190 200 210 220 230
390 400 410 420 430 440
pF1KB4 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
. :::...:..::: . . ....... ::.::: .: .::.: .::: : :.::
XP_011 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI
240 250 260 270 280 290
450 460 470 480 490 500
pF1KB4 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
:: ::..:..:: ::.:..:..:
XP_011 CHDHFGWYLGWGDCVWLPYLYTLQKRTRRQGVCQRQSWGLTPGRWAPEPTLLSSPWAKHR
300 310 320 330 340 350
>>NP_001351 (OMIM: 270400,602858) 7-dehydrocholesterol r (475 aa)
initn: 881 init1: 355 opt: 425 Z-score: 382.1 bits: 80.4 E(85289): 1.5e-14
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (203-615:31-475)
180 190 200 210 220 230
pF1KB4 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
:: ... :. . .::..:. : ... ...
NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
10 20 30 40 50
240 250 260 270
pF1KB4 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
: : . .: ... : ..: .. .: :: .:::.:
NP_001 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
60 70 80 90 100 110
280 290 300 310 320
pF1KB4 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
.:: .: . ::. : ::..::. :..:: . .. :.. ......
NP_001 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
120 130 140 150 160 170
330 340 350 360 370 380
pF1KB4 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
NP_001 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
180 190 200 210 220 230
390 400 410 420 430 440
pF1KB4 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
. :::...:..::: . . ...... . ::.::: .: .::.: .::: : :.::
NP_001 NGRPGIVAWTLINLSFAAKQRELHSHV--TNAMVLVNVLQAIYVIDFFWNETWYLKTIDI
240 250 260 270 280 290
450 460 470 480 490 500
pF1KB4 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
:: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: :
NP_001 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
300 310 320 330 340 350
510 520 530 540 550
pF1KB4 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
:. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .:
NP_001 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
360 370 380 390 400 410
560 570 580 590 600 610
pF1KB4 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
:. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :.
NP_001 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
420 430 440 450 460 470
>>NP_001157289 (OMIM: 270400,602858) 7-dehydrocholestero (475 aa)
initn: 881 init1: 355 opt: 425 Z-score: 382.1 bits: 80.4 E(85289): 1.5e-14
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (203-615:31-475)
180 190 200 210 220 230
pF1KB4 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
:: ... :. . .::..:. : ... ...
NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
10 20 30 40 50
240 250 260 270
pF1KB4 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
: : . .: ... : ..: .. .: :: .:::.:
NP_001 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
60 70 80 90 100 110
280 290 300 310 320
pF1KB4 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
.:: .: . ::. : ::..::. :..:: . .. :.. ......
NP_001 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
120 130 140 150 160 170
330 340 350 360 370 380
pF1KB4 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
. :... ..:.. .... : . . .:: :....: :.::::: ::.: :
NP_001 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
180 190 200 210 220 230
390 400 410 420 430 440
pF1KB4 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
. :::...:..::: . . ...... . ::.::: .: .::.: .::: : :.::
NP_001 NGRPGIVAWTLINLSFAAKQRELHSHV--TNAMVLVNVLQAIYVIDFFWNETWYLKTIDI
240 250 260 270 280 290
450 460 470 480 490 500
pF1KB4 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
:: ::..:..:: ::.:..:..:..::: :: ..: : : ...: : :: ::: :: :
NP_001 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
300 310 320 330 340 350
510 520 530 540 550
pF1KB4 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
:. ::.. . ::. . . .. :. .:::::.:: .:: ::.:::. .:
NP_001 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
360 370 380 390 400 410
560 570 580 590 600 610
pF1KB4 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
:. : :: .:.::::::::...::.:: :::..: .::: ::.: ::::..: :.
NP_001 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
420 430 440 450 460 470
615 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:09:43 2016 done: Thu Nov 3 15:09:44 2016
Total Scan time: 9.150 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]