Result of FASTA (omim) for
pF1KB4480
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4480, 359 aa
1>>>pF1KB4480 359 - 359 aa - 359 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1556+/-0.000464; mu= 16.5290+/- 0.029
mean_var=67.0622+/-13.632, 0's: 0 Z-trim(108.4): 176 B-trim: 80 in 1/52
Lambda= 0.156616
statistics sampled from 16253 (16448) to 16253 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.558), E-opt: 0.2 (0.193), width: 16
Scan time: 7.610
The best scores are: opt bits E(85289)
NP_005659 (OMIM: 602547) CMP-N-acetylneuraminate-p ( 359) 2388 549.2 5.3e-156
XP_005272135 (OMIM: 602547) PREDICTED: CMP-N-acety ( 282) 1737 402.0 8.4e-112
NP_001317345 (OMIM: 602546) alpha-2,8-sialyltransf ( 354) 1439 334.7 1.9e-91
NP_006002 (OMIM: 602546) alpha-2,8-sialyltransfera ( 375) 1404 326.8 4.7e-89
XP_016878131 (OMIM: 602546) PREDICTED: alpha-2,8-s ( 396) 1404 326.9 4.9e-89
NP_778222 (OMIM: 602547) CMP-N-acetylneuraminate-p ( 168) 1083 254.1 1.7e-67
XP_011541932 (OMIM: 602547) PREDICTED: CMP-N-acety ( 261) 1076 252.6 7.2e-67
NP_056963 (OMIM: 609478) sia-alpha-2,3-Gal-beta-1, ( 380) 765 182.5 1.4e-45
NP_001294916 (OMIM: 607162) alpha-2,8-sialyltransf ( 345) 579 140.4 5.7e-33
XP_016881204 (OMIM: 607162) PREDICTED: alpha-2,8-s ( 302) 578 140.1 6e-33
NP_037437 (OMIM: 607162) alpha-2,8-sialyltransfera ( 376) 578 140.2 7.2e-33
NP_001294915 (OMIM: 607162) alpha-2,8-sialyltransf ( 412) 578 140.2 7.7e-33
NP_003025 (OMIM: 601123) alpha-N-acetylneuraminide ( 356) 557 135.4 1.8e-31
XP_016871663 (OMIM: 610139) PREDICTED: alpha-2,8-s ( 368) 540 131.6 2.7e-30
NP_001004470 (OMIM: 610139) alpha-2,8-sialyltransf ( 398) 540 131.6 2.9e-30
XP_016881205 (OMIM: 607162) PREDICTED: alpha-2,8-s ( 228) 537 130.8 2.9e-30
NP_001332890 (OMIM: 610139) alpha-2,8-sialyltransf ( 247) 513 125.4 1.3e-28
NP_001291379 (OMIM: 601123) alpha-N-acetylneuramin ( 213) 381 95.5 1.1e-19
XP_016873623 (OMIM: 104240) PREDICTED: CMP-N-acety ( 329) 251 66.3 1.1e-10
NP_006269 (OMIM: 104240) CMP-N-acetylneuraminate-b ( 329) 251 66.3 1.1e-10
NP_001241688 (OMIM: 104240) CMP-N-acetylneuraminat ( 332) 251 66.3 1.1e-10
NP_001241686 (OMIM: 104240) CMP-N-acetylneuraminat ( 333) 251 66.3 1.1e-10
NP_001241687 (OMIM: 104240) CMP-N-acetylneuraminat ( 333) 251 66.3 1.1e-10
NP_112227 (OMIM: 610134) alpha-N-acetylgalactosami ( 336) 238 63.4 8.7e-10
XP_016860689 (OMIM: 604402,609056) PREDICTED: lact ( 390) 235 62.7 1.6e-09
XP_016860688 (OMIM: 604402,609056) PREDICTED: lact ( 390) 235 62.7 1.6e-09
XP_016860690 (OMIM: 604402,609056) PREDICTED: lact ( 390) 235 62.7 1.6e-09
NP_001035902 (OMIM: 604402,609056) lactosylceramid ( 395) 235 62.7 1.6e-09
NP_003887 (OMIM: 604402,609056) lactosylceramide a ( 418) 235 62.7 1.7e-09
XP_016860700 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860696 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860697 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860694 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860699 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_011531445 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860695 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860693 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860701 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860692 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860698 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_016860702 (OMIM: 604402,609056) PREDICTED: lact ( 290) 231 61.7 2.3e-09
XP_011540289 (OMIM: 606494) PREDICTED: CMP-N-acety ( 327) 226 60.6 5.6e-09
XP_011540290 (OMIM: 606494) PREDICTED: CMP-N-acety ( 327) 226 60.6 5.6e-09
XP_016857605 (OMIM: 606494) PREDICTED: CMP-N-acety ( 340) 226 60.6 5.8e-09
XP_011540285 (OMIM: 606494) PREDICTED: CMP-N-acety ( 340) 226 60.6 5.8e-09
XP_016857604 (OMIM: 606494) PREDICTED: CMP-N-acety ( 341) 226 60.6 5.8e-09
XP_016857603 (OMIM: 606494) PREDICTED: CMP-N-acety ( 341) 226 60.6 5.8e-09
XP_006710891 (OMIM: 606494) PREDICTED: CMP-N-acety ( 341) 226 60.6 5.8e-09
XP_011540282 (OMIM: 606494) PREDICTED: CMP-N-acety ( 379) 226 60.7 6.3e-09
XP_016857600 (OMIM: 606494) PREDICTED: CMP-N-acety ( 392) 226 60.7 6.5e-09
>>NP_005659 (OMIM: 602547) CMP-N-acetylneuraminate-poly- (359 aa)
initn: 2388 init1: 2388 opt: 2388 Z-score: 2921.7 bits: 549.2 E(85289): 5.3e-156
Smith-Waterman score: 2388; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359)
10 20 30 40 50 60
pF1KB4 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
250 260 270 280 290 300
310 320 330 340 350
pF1KB4 WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
310 320 330 340 350
>>XP_005272135 (OMIM: 602547) PREDICTED: CMP-N-acetylneu (282 aa)
initn: 1757 init1: 1737 opt: 1737 Z-score: 2128.2 bits: 402.0 E(85289): 8.4e-112
Smith-Waterman score: 1737; 99.6% identity (100.0% similar) in 267 aa overlap (1-267:1-267)
10 20 30 40 50 60
pF1KB4 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
::::::::::::::::::::::::::.
XP_005 NALILKNKLKVRTAYPSLRLIHAVRGFCENFLDFKEDLNNSN
250 260 270 280
>>NP_001317345 (OMIM: 602546) alpha-2,8-sialyltransferas (354 aa)
initn: 1352 init1: 1352 opt: 1439 Z-score: 1762.9 bits: 334.7 E(85289): 1.9e-91
Smith-Waterman score: 1439; 58.3% identity (83.4% similar) in 355 aa overlap (6-356:6-350)
10 20 30 40 50 60
pF1KB4 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
. : . ...::..: .:.. ::. .... .: .:: .. ...
NP_001 MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGAEVVING---------SSSPAVVDRSN
10 20 30 40 50
70 80 90 100 110
pF1KB4 SSIFQHNVEG----WKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRR
:: .::.. :. :..: :.:::.::.:::::.:.::.:...::::.:::..::
NP_001 ESI-KHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB4 TLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVE
:.:.:..:. :::..::.::..: :::.:::::.::.: ::.:::.:.:::::::::: :
NP_001 TMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB4 FAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKH
.: ::: :.:..::::::.:::: . : . :::...:: :: :.:::::::..::...
NP_001 YARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKER
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB4 VEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIH
::::: ::::....::::::::::.:::::::::::: ::::.::::::::::::: .:.
NP_001 VEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIY
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB4 LYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKC
:::::::: : : . :::::::.::: : :.:::: ::::::.:. ::..::::::.:.:
NP_001 LYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTVGQC
300 310 320 330 340 350
pF1KB4 VKQ
NP_001 DGAT
>>NP_006002 (OMIM: 602546) alpha-2,8-sialyltransferase 8 (375 aa)
initn: 1352 init1: 1352 opt: 1404 Z-score: 1719.8 bits: 326.8 E(85289): 4.7e-89
Smith-Waterman score: 1421; 57.9% identity (82.1% similar) in 368 aa overlap (6-356:6-371)
10 20 30 40
pF1KB4 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGEL-----SL-SRS-----LV
. : . ...::..: .:.. ::. .. : : . :: :.: ..
NP_006 MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSG-GRGTIRSAVNSLHSKSNRAEVVI
10 20 30 40 50
50 60 70 80 90 100
pF1KB4 N--SSDKIIRKAGSSIFQHNVEG----WKINSSLVLEIRKNILRFLDAERDVSVVKSSFK
: :: .. ... :: .::.. :. :..: :.:::.::.:::::.:.::.:...:
NP_006 NGSSSPAVVDRSNESI-KHNIQPASSKWRHNQTLSLRIRKQILKFLDAEKDISVLKGTLK
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB4 PGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSH
:::.:::..:: :.:.:..:. :::..::.::..: :::.:::::.::.: ::.:::.:
NP_006 PGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAH
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB4 NFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVL
.:::::::::: :.: ::: :.:..::::::.:::: . : . :::...:: :: :.:
NP_006 SFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSIL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB4 WIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLL
::::::..::...::::: ::::....::::::::::.:::::::::::: ::::.::::
NP_006 WIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB4 MYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL
::::::::: .:.:::::::: : : . :::::::.::: : :.:::: ::::::.:. :
NP_006 MYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL
300 310 320 330 340 350
350
pF1KB4 HNRGALKLTTGKCVKQ
:..::::::.:.:
NP_006 HEQGALKLTVGQCDGAT
360 370
>>XP_016878131 (OMIM: 602546) PREDICTED: alpha-2,8-sialy (396 aa)
initn: 1352 init1: 1352 opt: 1404 Z-score: 1719.5 bits: 326.9 E(85289): 4.9e-89
Smith-Waterman score: 1404; 64.0% identity (87.5% similar) in 311 aa overlap (50-356:83-392)
20 30 40 50 60 70
pF1KB4 YKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEG----WKINS
.:: .. ... :: .::.. :. :.
XP_016 KRNSGGRGTIRSAVNSLHSKSNRAEVVINGSSSPAVVDRSNESI-KHNIQPASSKWRHNQ
60 70 80 90 100 110
80 90 100 110 120 130
pF1KB4 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMK
.: :.:::.::.:::::.:.::.:...::::.:::..:: :.:.:..:. :::..::.:
XP_016 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLK
120 130 140 150 160 170
140 150 160 170 180 190
pF1KB4 NRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVV
:..: :::.:::::.::.: ::.:::.:.:::::::::: :.: ::: :.:..::::::.
XP_016 NKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVI
180 190 200 210 220 230
200 210 220 230 240 250
pF1KB4 QRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAY
:::: . : . :::...:: :: :.:::::::..::...::::: ::::....:::::
XP_016 QRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEWVNELILKHHVNVRTAY
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB4 PSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH
:::::.:::::::::::: ::::.::::::::::::: .:.:::::::: : : . ::::
XP_016 PSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYH
300 310 320 330 340 350
320 330 340 350
pF1KB4 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
:::.::: : :.:::: ::::::.:. ::..::::::.:.:
XP_016 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTVGQCDGAT
360 370 380 390
>>NP_778222 (OMIM: 602547) CMP-N-acetylneuraminate-poly- (168 aa)
initn: 1083 init1: 1083 opt: 1083 Z-score: 1332.9 bits: 254.1 E(85289): 1.7e-67
Smith-Waterman score: 1083; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)
10 20 30 40 50 60
pF1KB4 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
::::::::::::::::::::::::::::::::::::::::::::::::
NP_778 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIR
130 140 150 160
190 200 210 220 230 240
pF1KB4 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
>>XP_011541932 (OMIM: 602547) PREDICTED: CMP-N-acetylneu (261 aa)
initn: 1076 init1: 1076 opt: 1076 Z-score: 1321.5 bits: 252.6 E(85289): 7.2e-67
Smith-Waterman score: 1525; 72.4% identity (72.7% similar) in 359 aa overlap (1-359:1-261)
10 20 30 40 50 60
pF1KB4 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAAD
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVI-------------
130 140 150 160
190 200 210 220 230 240
pF1KB4 VGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV
XP_011 ------------------------------------------------------------
250 260 270 280 290 300
pF1KB4 NALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
.::::::::::::::::::::::::::::::::::
XP_011 -------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGF
170 180 190 200
310 320 330 340 350
pF1KB4 WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
210 220 230 240 250 260
>>NP_056963 (OMIM: 609478) sia-alpha-2,3-Gal-beta-1,4-Gl (380 aa)
initn: 677 init1: 392 opt: 765 Z-score: 939.4 bits: 182.5 E(85289): 1.4e-45
Smith-Waterman score: 765; 39.3% identity (73.5% similar) in 298 aa overlap (64-356:83-379)
40 50 60 70 80 90
pF1KB4 TQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAER
.:.. ::.: . :. :..::. .:. .
NP_056 YMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIK
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB4 DVSVVKSSFKPGDVIHY-VLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILL
. :..:.: . :...:: ... ...::....::::.:::. :.... ::::::::::
NP_056 NFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILT
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB4 DSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFV
:.::.:::. .::.:::.::. : ::: :... :.:::.... .... . .::..:
NP_056 GSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFF
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB4 HRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNK--LKVRTAYPSLRLIHAVRGYWLT
:. :. ..::::::. . . .. . ...... :::. :.:. . :. : :: .
NP_056 LSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNR-YWKN
240 250 260 270 280 290
280 290 300 310 320
pF1KB4 NKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKA-VKYHYYDDLKYRYFSN-A
... :: :::.::::::. .:.:::::::::: : : . . ::::: .. ..
NP_056 KHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQ
300 310 320 330 340 350
330 340 350
pF1KB4 SPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
:..: ::. : .:..: ::: ..:
NP_056 ESHQLPAEFQLLYRMHGEGLTKLTLSHCA
360 370 380
>>NP_001294916 (OMIM: 607162) alpha-2,8-sialyltransferas (345 aa)
initn: 514 init1: 215 opt: 579 Z-score: 712.9 bits: 140.4 E(85289): 5.7e-33
Smith-Waterman score: 579; 32.0% identity (64.9% similar) in 322 aa overlap (42-356:29-342)
20 30 40 50 60
pF1KB4 TISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQH----N
..: .... . . : : : .:.. .
NP_001 MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRVKQSELFDRWKSLQ
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 VEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSL
. : .: : . ...... : .: . ..... : ..: .: .:.... .
NP_001 MCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRM
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 LPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVE-FAADVGTKSD
.:. :. .:: ::::::.::: .:.::.::.: .::.:::: :. : .. :::.:.:
NP_001 FPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 FITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFM-VKGGEKHVEWVNALI-
.:.:::.. . : . :. :. : . :.. ... . .:::. ... . .. .:
NP_001 VVTVNPSIITERF--HKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDD
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB4 LKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFP
... : .:. :... : :::. : :: ::::.. : : ..:.:.::.::: ::
NP_001 FESPQAVYYFHPQY-LVNVSR-YWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFP
240 250 260 270 280 290
310 320 330 340 350
pF1KB4 KDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
. .: . .::::..: : . : :: :. .. ::.:: :.. :: :
NP_001 MNPSGLYITHHYYDNVKPR----PGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC
300 310 320 330 340
>>XP_016881204 (OMIM: 607162) PREDICTED: alpha-2,8-sialy (302 aa)
initn: 514 init1: 215 opt: 578 Z-score: 712.5 bits: 140.1 E(85289): 6e-33
Smith-Waterman score: 578; 33.9% identity (66.1% similar) in 289 aa overlap (71-356:19-299)
50 60 70 80 90 100
pF1KB4 ELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKS
: .: : . ...... : .: . ....
XP_016 MVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQK
10 20 30 40
110 120 130 140 150 160
pF1KB4 SFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEI
. : ..: .: .:.... ..:. :. .:: ::::::.::: .:.::.::
XP_016 NTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREI
50 60 70 80 90 100
170 180 190 200 210
pF1KB4 DSHNFVIRCNLAPVVE-FAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLN
.: .::.:::: :. : .. :::.:.: .:.:::.. . : . :. :. : . :.. .
XP_016 NSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERF--HKLEKWRRPFYRVLQVYE
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB4 DSVLWIPAFM-VKGGEKHVEWVNALI-LKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKR
.. . .:::. ... . .. .: ... : .:. :... : :::. : ::
XP_016 NASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQY-LVNVSR-YWLSLGVRAKR
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB4 PSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEF
::::.. : : ..:.:.::.::: :: . .: . .::::..: : . : :: :.
XP_016 ISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR----PGFHAMPSEI
230 240 250 260 270 280
340 350
pF1KB4 KTLNVLHNRGALKLTTGKCVKQ
.. ::.:: :.. :: :
XP_016 FNFLHLHSRGILRVHTGTCSCC
290 300
359 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 05:51:46 2016 done: Sat Nov 5 05:51:47 2016
Total Scan time: 7.610 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]