Result of FASTA (omim) for
pF1KB3726
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3726, 859 aa
1>>>pF1KB3726 859 - 859 aa - 859 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7197+/-0.000454; mu= 14.9311+/- 0.028
mean_var=135.2141+/-28.331, 0's: 0 Z-trim(114.1): 542 B-trim: 8 in 1/55
Lambda= 0.110297
statistics sampled from 23158 (23773) to 23158 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.634), E-opt: 0.2 (0.279), width: 16
Scan time: 10.240
The best scores are: opt bits E(85289)
NP_068781 (OMIM: 600365) active breakpoint cluster ( 859) 5640 910.0 0
NP_001309770 (OMIM: 600365) active breakpoint clus (1118) 5501 888.0 0
NP_001153218 (OMIM: 600365) active breakpoint clus ( 813) 5316 858.5 0
NP_001309769 (OMIM: 600365) active breakpoint clus ( 813) 5316 858.5 0
NP_001083 (OMIM: 600365) active breakpoint cluster ( 822) 5070 819.3 0
XP_011522112 (OMIM: 600365) PREDICTED: active brea ( 878) 4607 745.7 2.2e-214
XP_016880028 (OMIM: 600365) PREDICTED: active brea (1137) 4468 723.6 1.2e-207
XP_011522116 (OMIM: 600365) PREDICTED: active brea ( 832) 4283 694.1 7e-199
XP_011522117 (OMIM: 600365) PREDICTED: active brea ( 832) 4283 694.1 7e-199
NP_001269078 (OMIM: 600365) active breakpoint clus ( 641) 4094 663.9 6.5e-190
XP_011522115 (OMIM: 600365) PREDICTED: active brea ( 841) 4037 654.9 4.3e-187
XP_011522114 (OMIM: 600365) PREDICTED: active brea ( 865) 4032 654.2 7.6e-187
XP_016880029 (OMIM: 600365) PREDICTED: active brea (1104) 3840 623.7 1.4e-177
XP_016880030 (OMIM: 600365) PREDICTED: active brea ( 863) 3814 619.5 2.1e-176
XP_011522113 (OMIM: 600365) PREDICTED: active brea ( 873) 3809 618.7 3.7e-176
NP_004318 (OMIM: 151410,608232,613065) breakpoint (1271) 3778 613.9 1.5e-174
XP_016880032 (OMIM: 600365) PREDICTED: active brea ( 660) 3061 499.6 2e-140
XP_016880031 (OMIM: 600365) PREDICTED: active brea ( 663) 3061 499.6 2e-140
NP_067585 (OMIM: 151410,608232,613065) breakpoint (1227) 2306 379.6 4.7e-104
NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 1694 281.7 3.5e-75
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 474 87.8 1.5e-16
XP_011522776 (OMIM: 610591) PREDICTED: rho GTPase- ( 581) 474 87.8 1.5e-16
XP_005257185 (OMIM: 610591) PREDICTED: rho GTPase- ( 667) 474 87.9 1.7e-16
XP_016879801 (OMIM: 610591) PREDICTED: rho GTPase- ( 689) 474 87.9 1.7e-16
XP_011522774 (OMIM: 610591) PREDICTED: rho GTPase- ( 722) 474 87.9 1.8e-16
XP_011522773 (OMIM: 610591) PREDICTED: rho GTPase- ( 865) 474 88.0 2.1e-16
XP_006721810 (OMIM: 610591) PREDICTED: rho GTPase- ( 867) 474 88.0 2.1e-16
NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 474 88.0 2.1e-16
XP_006721808 (OMIM: 610591) PREDICTED: rho GTPase- ( 889) 474 88.0 2.1e-16
XP_011522771 (OMIM: 610591) PREDICTED: rho GTPase- ( 900) 474 88.0 2.1e-16
XP_016879800 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 474 88.0 2.2e-16
XP_011522770 (OMIM: 610591) PREDICTED: rho GTPase- ( 922) 474 88.0 2.2e-16
XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 440 82.3 4.9e-15
XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 440 82.3 5.2e-15
NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 440 82.4 5.6e-15
XP_016859988 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 440 82.4 5.6e-15
XP_011509781 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 440 82.4 5.6e-15
NP_001193531 (OMIM: 118423,604356) N-chimaerin iso ( 334) 421 79.2 3.5e-14
NP_001020372 (OMIM: 118423,604356) N-chimaerin iso ( 433) 421 79.3 4.2e-14
NP_001813 (OMIM: 118423,604356) N-chimaerin isofor ( 459) 421 79.3 4.4e-14
XP_016872443 (OMIM: 610577) PREDICTED: rho GTPase- ( 742) 421 79.5 6.3e-14
NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 421 79.5 6.5e-14
XP_011518063 (OMIM: 610577) PREDICTED: rho GTPase- ( 772) 421 79.5 6.5e-14
NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 421 79.5 6.7e-14
XP_005252701 (OMIM: 610577) PREDICTED: rho GTPase- ( 794) 421 79.5 6.7e-14
NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 421 79.5 6.7e-14
NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 421 79.5 6.8e-14
NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 421 79.6 6.9e-14
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 421 79.6 7e-14
NP_001280010 (OMIM: 602857) beta-chimaerin isoform ( 261) 383 73.1 1.9e-12
>>NP_068781 (OMIM: 600365) active breakpoint cluster reg (859 aa)
initn: 5640 init1: 5640 opt: 5640 Z-score: 4858.4 bits: 910.0 E(85289): 0
Smith-Waterman score: 5640; 100.0% identity (100.0% similar) in 859 aa overlap (1-859:1-859)
10 20 30 40 50 60
pF1KB3 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 SARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 KATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 KATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 QLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 NSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 KLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 KLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 QTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 QTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 LKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 RVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH
790 800 810 820 830 840
850
pF1KB3 PPISFAELKRNTLYFSTDV
:::::::::::::::::::
NP_068 PPISFAELKRNTLYFSTDV
850
>>NP_001309770 (OMIM: 600365) active breakpoint cluster (1118 aa)
initn: 5501 init1: 5501 opt: 5501 Z-score: 4737.3 bits: 888.0 E(85289): 0
Smith-Waterman score: 5501; 99.4% identity (99.8% similar) in 844 aa overlap (16-859:275-1118)
10 20 30 40
pF1KB3 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSE
: . ..::::::::::::::::::::::::
NP_001 RFLRVPERDSPGHSSPERDSDGSRHSSDREDDFSADFSYGTDEYDGEGNEEQKGPPEGSE
250 260 270 280 290 300
50 60 70 80 90 100
pF1KB3 TMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEI
310 320 330 340 350 360
110 120 130 140 150 160
pF1KB3 YINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWD
370 380 390 400 410 420
170 180 190 200 210 220
pF1KB3 SQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKD
430 440 450 460 470 480
230 240 250 260 270 280
pF1KB3 SHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDI
490 500 510 520 530 540
290 300 310 320 330 340
pF1KB3 DPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYD
550 560 570 580 590 600
350 360 370 380 390 400
pF1KB3 CKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIE
610 620 630 640 650 660
410 420 430 440 450 460
pF1KB3 RLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAF
670 680 690 700 710 720
470 480 490 500 510 520
pF1KB3 VLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCT
730 740 750 760 770 780
530 540 550 560 570 580
pF1KB3 LEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNE
790 800 810 820 830 840
590 600 610 620 630 640
pF1KB3 IVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVF
850 860 870 880 890 900
650 660 670 680 690 700
pF1KB3 GVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDI
910 920 930 940 950 960
710 720 730 740 750 760
pF1KB3 LLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLP
970 980 990 1000 1010 1020
770 780 790 800 810 820
pF1KB3 DPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSH
1030 1040 1050 1060 1070 1080
830 840 850
pF1KB3 DVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
::::::::::::::::::::::::::::::::::
NP_001 DVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
1090 1100 1110
>>NP_001153218 (OMIM: 600365) active breakpoint cluster (813 aa)
initn: 5316 init1: 5316 opt: 5316 Z-score: 4580.1 bits: 858.5 E(85289): 0
Smith-Waterman score: 5316; 100.0% identity (100.0% similar) in 813 aa overlap (47-859:1-813)
20 30 40 50 60 70
pF1KB3 TLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPP
::::::::::::::::::::::::::::::
NP_001 MPYIDESPTMSPQLSARSQGGGDGVSPTPP
10 20 30
80 90 100 110 120 130
pF1KB3 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KB3 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
520 530 540 550 560 570
620 630 640 650 660 670
pF1KB3 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
580 590 600 610 620 630
680 690 700 710 720 730
pF1KB3 EEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDR
640 650 660 670 680 690
740 750 760 770 780 790
pF1KB3 LYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNL
700 710 720 730 740 750
800 810 820 830 840 850
pF1KB3 ATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFS
760 770 780 790 800 810
pF1KB3 TDV
:::
NP_001 TDV
>>NP_001309769 (OMIM: 600365) active breakpoint cluster (813 aa)
initn: 5316 init1: 5316 opt: 5316 Z-score: 4580.1 bits: 858.5 E(85289): 0
Smith-Waterman score: 5316; 100.0% identity (100.0% similar) in 813 aa overlap (47-859:1-813)
20 30 40 50 60 70
pF1KB3 TLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPP
::::::::::::::::::::::::::::::
NP_001 MPYIDESPTMSPQLSARSQGGGDGVSPTPP
10 20 30
80 90 100 110 120 130
pF1KB3 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KB3 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
520 530 540 550 560 570
620 630 640 650 660 670
pF1KB3 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
580 590 600 610 620 630
680 690 700 710 720 730
pF1KB3 EEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDR
640 650 660 670 680 690
740 750 760 770 780 790
pF1KB3 LYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNL
700 710 720 730 740 750
800 810 820 830 840 850
pF1KB3 ATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFS
760 770 780 790 800 810
pF1KB3 TDV
:::
NP_001 TDV
>>NP_001083 (OMIM: 600365) active breakpoint cluster reg (822 aa)
initn: 5062 init1: 5062 opt: 5070 Z-score: 4368.4 bits: 819.3 E(85289): 0
Smith-Waterman score: 5070; 98.5% identity (98.9% similar) in 793 aa overlap (72-859:30-822)
50 60 70 80 90
pF1KB3 EGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAP-----GVEAGKGLEMRKLVL
.:: : . .: ::::::::::::::
NP_001 MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVL
10 20 30 40 50
100 110 120 130 140 150
pF1KB3 SGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDN
60 70 80 90 100 110
160 170 180 190 200 210
pF1KB3 LCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELK
120 130 140 150 160 170
220 230 240 250 260 270
pF1KB3 VKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQN
180 190 200 210 220 230
280 290 300 310 320 330
pF1KB3 FLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKT
240 250 260 270 280 290
340 350 360 370 380 390
pF1KB3 SAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKA
300 310 320 330 340 350
400 410 420 430 440 450
pF1KB3 NKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQK
360 370 380 390 400 410
460 470 480 490 500 510
pF1KB3 LQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGF
420 430 440 450 460 470
520 530 540 550 560 570
pF1KB3 KQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDK
480 490 500 510 520 530
580 590 600 610 620 630
pF1KB3 TKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRT
540 550 560 570 580 590
640 650 660 670 680 690
pF1KB3 PSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKA
600 610 620 630 640 650
700 710 720 730 740 750
pF1KB3 VFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENC
660 670 680 690 700 710
760 770 780 790 800 810
pF1KB3 MMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHL
720 730 740 750 760 770
820 830 840 850
pF1KB3 TSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
:::::::::::::::::::::::::::::::::::::::::::
NP_001 TSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
780 790 800 810 820
>>XP_011522112 (OMIM: 600365) PREDICTED: active breakpoi (878 aa)
initn: 4607 init1: 4607 opt: 4607 Z-score: 3969.9 bits: 745.7 E(85289): 2.2e-214
Smith-Waterman score: 5586; 97.7% identity (97.8% similar) in 878 aa overlap (1-859:1-878)
10 20 30 40 50 60
pF1KB3 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 KATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 KLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 QTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKV
610 620 630 640 650 660
670 680 690 700
pF1KB3 PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDAN-------------------
::::::::::::::::::::::::::::::::::::::::.
XP_011 PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDASKQLQKLTRADSLAQDDPTY
670 680 690 700 710 720
710 720 730 740 750 760
pF1KB3 NKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLL
730 740 750 760 770 780
770 780 790 800 810 820
pF1KB3 RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAAD
790 800 810 820 830 840
830 840 850
pF1KB3 IWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
::::::::::::::::::::::::::::::::::::::
XP_011 IWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
850 860 870
>>XP_016880028 (OMIM: 600365) PREDICTED: active breakpoi (1137 aa)
initn: 4468 init1: 4468 opt: 4468 Z-score: 3848.9 bits: 723.6 E(85289): 1.2e-207
Smith-Waterman score: 5447; 97.1% identity (97.6% similar) in 863 aa overlap (16-859:275-1137)
10 20 30 40
pF1KB3 MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSE
: . ..::::::::::::::::::::::::
XP_016 RFLRVPERDSPGHSSPERDSDGSRHSSDREDDFSADFSYGTDEYDGEGNEEQKGPPEGSE
250 260 270 280 290 300
50 60 70 80 90 100
pF1KB3 TMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEI
310 320 330 340 350 360
110 120 130 140 150 160
pF1KB3 YINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWD
370 380 390 400 410 420
170 180 190 200 210 220
pF1KB3 SQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKD
430 440 450 460 470 480
230 240 250 260 270 280
pF1KB3 SHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDI
490 500 510 520 530 540
290 300 310 320 330 340
pF1KB3 DPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYD
550 560 570 580 590 600
350 360 370 380 390 400
pF1KB3 CKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIE
610 620 630 640 650 660
410 420 430 440 450 460
pF1KB3 RLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAF
670 680 690 700 710 720
470 480 490 500 510 520
pF1KB3 VLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCT
730 740 750 760 770 780
530 540 550 560 570 580
pF1KB3 LEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNE
790 800 810 820 830 840
590 600 610 620 630 640
pF1KB3 IVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVF
850 860 870 880 890 900
650 660 670 680 690 700
pF1KB3 GVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDAN----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 GVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDASKQLQ
910 920 930 940 950 960
710 720 730 740
pF1KB3 ---------------NKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLTRADSLAQDDPTYNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA
970 980 990 1000 1010 1020
750 760 770 780 790 800
pF1KB3 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLR
1030 1040 1050 1060 1070 1080
810 820 830 840 850
pF1KB3 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
1090 1100 1110 1120 1130
>>XP_011522116 (OMIM: 600365) PREDICTED: active breakpoi (832 aa)
initn: 4283 init1: 4283 opt: 4283 Z-score: 3691.6 bits: 694.1 E(85289): 7e-199
Smith-Waterman score: 5262; 97.6% identity (97.7% similar) in 832 aa overlap (47-859:1-832)
20 30 40 50 60 70
pF1KB3 TLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPP
::::::::::::::::::::::::::::::
XP_011 MPYIDESPTMSPQLSARSQGGGDGVSPTPP
10 20 30
80 90 100 110 120 130
pF1KB3 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KB3 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
520 530 540 550 560 570
620 630 640 650 660 670
pF1KB3 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
580 590 600 610 620 630
680 690 700 710
pF1KB3 EEVGIYRISGVATDIQALKAVFDAN-------------------NKDILLMLSDMDINAI
::::::::::::::::::::::::. ::::::::::::::::
XP_011 EEVGIYRISGVATDIQALKAVFDASKQLQKLTRADSLAQDDPTYNKDILLMLSDMDINAI
640 650 660 670 680 690
720 730 740 750 760 770
pF1KB3 AGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLE
700 710 720 730 740 750
780 790 800 810 820 830
pF1KB3 HLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY
760 770 780 790 800 810
840 850
pF1KB3 LQHPPISFAELKRNTLYFSTDV
::::::::::::::::::::::
XP_011 LQHPPISFAELKRNTLYFSTDV
820 830
>>XP_011522117 (OMIM: 600365) PREDICTED: active breakpoi (832 aa)
initn: 4283 init1: 4283 opt: 4283 Z-score: 3691.6 bits: 694.1 E(85289): 7e-199
Smith-Waterman score: 5262; 97.6% identity (97.7% similar) in 832 aa overlap (47-859:1-832)
20 30 40 50 60 70
pF1KB3 TLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPP
::::::::::::::::::::::::::::::
XP_011 MPYIDESPTMSPQLSARSQGGGDGVSPTPP
10 20 30
80 90 100 110 120 130
pF1KB3 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KB3 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMN
520 530 540 550 560 570
620 630 640 650 660 670
pF1KB3 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGI
580 590 600 610 620 630
680 690 700 710
pF1KB3 EEVGIYRISGVATDIQALKAVFDAN-------------------NKDILLMLSDMDINAI
::::::::::::::::::::::::. ::::::::::::::::
XP_011 EEVGIYRISGVATDIQALKAVFDASKQLQKLTRADSLAQDDPTYNKDILLMLSDMDINAI
640 650 660 670 680 690
720 730 740 750 760 770
pF1KB3 AGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLE
700 710 720 730 740 750
780 790 800 810 820 830
pF1KB3 HLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY
760 770 780 790 800 810
840 850
pF1KB3 LQHPPISFAELKRNTLYFSTDV
::::::::::::::::::::::
XP_011 LQHPPISFAELKRNTLYFSTDV
820 830
>>NP_001269078 (OMIM: 600365) active breakpoint cluster (641 aa)
initn: 4094 init1: 4094 opt: 4094 Z-score: 3530.5 bits: 663.9 E(85289): 6.5e-190
Smith-Waterman score: 4094; 100.0% identity (100.0% similar) in 626 aa overlap (234-859:16-641)
210 220 230 240 250 260
pF1KB3 SNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPD
::::::::::::::::::::::::::::::
NP_001 MEILLIIRFCCNCTYALLYKPIDRVTRSTLVLHDLLKHTPVDHPD
10 20 30 40
270 280 290 300 310 320
pF1KB3 YPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFL
50 60 70 80 90 100
330 340 350 360 370 380
pF1KB3 FTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMK
110 120 130 140 150 160
390 400 410 420 430 440
pF1KB3 ISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSS
170 180 190 200 210 220
450 460 470 480 490 500
pF1KB3 DYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLY
230 240 250 260 270 280
510 520 530 540 550 560
pF1KB3 GFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQ
290 300 310 320 330 340
570 580 590 600 610 620
pF1KB3 SLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFS
350 360 370 380 390 400
630 640 650 660 670 680
pF1KB3 MKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYR
410 420 430 440 450 460
690 700 710 720 730 740
pF1KB3 ISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME
470 480 490 500 510 520
750 760 770 780 790 800
pF1KB3 GIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPT
530 540 550 560 570 580
810 820 830 840 850
pF1KB3 LLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
590 600 610 620 630 640
859 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:50:52 2016 done: Thu Nov 3 13:50:54 2016
Total Scan time: 10.240 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]