Result of FASTA (omim) for
pF1KB0465
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0465, 478 aa
1>>>pF1KB0465 478 - 478 aa - 478 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4437+/-0.000309; mu= 19.0321+/- 0.020
mean_var=89.6262+/-18.131, 0's: 0 Z-trim(117.9): 169 B-trim: 306 in 1/57
Lambda= 0.135474
statistics sampled from 30085 (30255) to 30085 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.355), width: 16
Scan time: 9.790
The best scores are: opt bits E(85289)
NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 484) 3217 638.6 1.1e-182
NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 3082 612.2 9.6e-175
NP_998786 (OMIM: 182139) 5-hydroxytryptamine recep ( 516) 2043 409.2 1.4e-113
NP_006019 (OMIM: 604654) 5-hydroxytryptamine recep ( 441) 1135 231.6 3.3e-60
XP_011541365 (OMIM: 604654) PREDICTED: 5-hydroxytr ( 430) 1133 231.2 4.3e-60
XP_016874041 (OMIM: 604654) PREDICTED: 5-hydroxytr ( 372) 996 204.4 4.4e-52
NP_001243542 (OMIM: 610123) 5-hydroxytryptamine re ( 456) 957 196.9 1e-49
NP_872395 (OMIM: 610123) 5-hydroxytryptamine recep ( 471) 957 196.9 1e-49
NP_570126 (OMIM: 610121) 5-hydroxytryptamine recep ( 447) 929 191.4 4.4e-48
NP_938055 (OMIM: 610123) 5-hydroxytryptamine recep ( 441) 856 177.1 8.6e-44
NP_938056 (OMIM: 610123) 5-hydroxytryptamine recep ( 456) 856 177.1 8.9e-44
NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 776 161.5 4.5e-39
NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 737 154.0 1.1e-36
NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 734 153.3 1.3e-36
NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 730 152.5 2.4e-36
NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 724 151.4 5.5e-36
NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 715 149.6 2e-35
XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 715 149.6 2e-35
XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 715 149.6 2e-35
NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 714 149.4 2.2e-35
NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 714 149.4 2.2e-35
NP_001243543 (OMIM: 610123) 5-hydroxytryptamine re ( 482) 712 149.0 2.7e-35
NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 698 146.3 1.8e-34
NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 686 143.9 8.9e-34
NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 683 143.3 1.4e-33
NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 683 143.4 1.4e-33
XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 682 143.1 1.6e-33
NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 682 143.2 1.6e-33
XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 671 141.0 6.7e-33
XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 671 141.0 6.9e-33
XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 671 141.0 6.9e-33
NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 671 141.0 7.2e-33
NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 670 140.8 8.5e-33
XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 668 140.4 1.1e-32
XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 668 140.4 1.1e-32
XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 662 139.2 2.3e-32
XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 662 139.2 2.3e-32
XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 653 137.5 8.2e-32
XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 644 135.8 3e-31
XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 627 132.4 2.6e-30
XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 606 128.2 4.3e-29
XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 606 128.2 4.3e-29
XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 605 128.0 4.5e-29
NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 586 124.4 7.1e-28
NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 559 119.1 2.8e-26
XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 559 119.1 2.8e-26
NP_005190 (OMIM: 100730,253290,265000) acetylcholi ( 517) 525 112.5 2.9e-24
XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 488 105.3 4.6e-22
XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 482 104.0 8.1e-22
XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 482 104.0 8.3e-22
>>NP_000860 (OMIM: 182139) 5-hydroxytryptamine receptor (484 aa)
initn: 3217 init1: 3217 opt: 3217 Z-score: 3400.5 bits: 638.6 E(85289): 1.1e-182
Smith-Waterman score: 3217; 100.0% identity (100.0% similar) in 478 aa overlap (1-478:7-484)
10 20 30 40 50
pF1KB0 MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 LPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 LCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI
430 440 450 460 470 480
pF1KB0 WQYA
::::
NP_000 WQYA
>>NP_001155244 (OMIM: 182139) 5-hydroxytryptamine recept (463 aa)
initn: 3082 init1: 3082 opt: 3082 Z-score: 3258.2 bits: 612.2 E(85289): 9.6e-175
Smith-Waterman score: 3082; 99.8% identity (100.0% similar) in 457 aa overlap (22-478:7-463)
10 20 30 40 50 60
pF1KB0 MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
.::::::::::::::::::::::::::::::::::::::
NP_001 MHRSFLQARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
10 20 30 40
70 80 90 100 110 120
pF1KB0 VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB0 LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB0 TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB0 RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB0 GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB0 STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
350 360 370 380 390 400
430 440 450 460 470
pF1KB0 ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
410 420 430 440 450 460
>>NP_998786 (OMIM: 182139) 5-hydroxytryptamine receptor (516 aa)
initn: 2099 init1: 2043 opt: 2043 Z-score: 2160.1 bits: 409.2 E(85289): 1.4e-113
Smith-Waterman score: 3143; 93.7% identity (93.7% similar) in 510 aa overlap (1-478:7-516)
10 20 30 40 50
pF1KB0 MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 WRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDS
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 IWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 FTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKF
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 YVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDT
250 260 270 280 290 300
300 310 320
pF1KB0 LPATAIGTPLIG--------------------------------VYFVVCMALLVISLAE
:::::::::::: ::::::::::::::::
NP_998 LPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAE
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB0 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 TIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMG
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB0 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_998 NHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDW
430 440 450 460 470 480
450 460 470
pF1KB0 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
::::::::::::::::::::::::::::::::::::
NP_998 LRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
490 500 510
>>NP_006019 (OMIM: 604654) 5-hydroxytryptamine receptor (441 aa)
initn: 1293 init1: 758 opt: 1135 Z-score: 1201.9 bits: 231.6 E(85289): 3.3e-60
Smith-Waterman score: 1245; 42.2% identity (70.7% similar) in 464 aa overlap (17-475:14-438)
10 20 30 40 50
pF1KB0 MLLWVQQALLALLLPTLLAQG-EARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPT
:.: : : ... :: .:: :: .:.: :::: .: : :
NP_006 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKAT
10 20 30 40 50
60 70 80 90 100 110
pF1KB0 TVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPD
:: .:..:.:::.:: .::.: : .::.. :.::::.:: ::.: ..:.: ..::.::
NP_006 TVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB0 ILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWL
:.::::::. . :..::::. .: ..::::.:::.::::. : :::::::::::: : :
NP_006 IIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSIL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB0 HTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIR
::..:..... : :: .. :...:.:..:::::.: . .. :.. .:...: ::.:
NP_006 HTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ-SSAGGFAQIQFNVVMR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB0 RRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATA
:.:: ::::::.::::::..:. .:::::: :. :: ..:.::.:: . .:. .: ..
NP_006 RHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB0 IGTPLIGVYFVVCMALLVISLAETIFIVRLVH-KQDLQQPVPAWLRHLVLERIAWLLCLR
.::::: .:..:::.::.:::..: .:...: .: : : .::::
NP_006 GSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP-------------FLCLR
300 310 320 330 340
360 370 380 390 400 410
pF1KB0 EQSTSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAV
.. ..:: : ...:. :.. : .:.: .. : ..
NP_006 GDTDADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE----------------------
350 360 370 380
420 430 440 450 460 470
pF1KB0 CGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIW
. ..:.:: ..:. .:. . .:: . : .:.:::. ::. . :.::: ::..:
NP_006 --VWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALW
390 400 410 420 430
pF1KB0 QYA
NP_006 GGV
440
>>XP_011541365 (OMIM: 604654) PREDICTED: 5-hydroxytrypta (430 aa)
initn: 1293 init1: 758 opt: 1133 Z-score: 1199.9 bits: 231.2 E(85289): 4.3e-60
Smith-Waterman score: 1243; 41.5% identity (70.2% similar) in 470 aa overlap (10-475:1-427)
10 20 30 40 50 60
pF1KB0 MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
. . .: .:: ... :: .:: :: .:.: :::: .: : ::
XP_011 MIVYFPGILATD----THHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATT
10 20 30 40
70 80 90 100 110 120
pF1KB0 VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
: .:..:.:::.:: .::.: : .::.. :.::::.:: ::.: ..:.: ..::.:::
XP_011 VYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB0 LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
.::::::. . :..::::. .: ..::::.:::.::::. : :::::::::::: : ::
XP_011 IINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILH
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB0 TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
:..:..... : :: .. :...:.:..:::::.: . .. :.. .:...: ::.::
XP_011 TVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ-SSAGGFAQIQFNVVMRR
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB0 RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
.:: ::::::.::::::..:. .:::::: :. :: ..:.::.:: . .:. .: ..
XP_011 HPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVG
230 240 250 260 270 280
310 320 330 340 350
pF1KB0 GTPLIGVYFVVCMALLVISLAETIFIVRLVH-KQDLQQPVPAWLRHLVLERIAWLLCLRE
.::::: .:..:::.::.:::..: .:...: .: : : .::::
XP_011 STPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP-------------FLCLRG
290 300 310 320 330
360 370 380 390 400 410
pF1KB0 QSTSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVC
.. ..:: : ...:. :.. : .:.: .. : ..
XP_011 DTDADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE-----------------------
340 350 360
420 430 440 450 460 470
pF1KB0 GLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQ
. ..:.:: ..:. .:. . .:: . : .:.:::. ::. . :.::: ::..:
XP_011 -VWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWG
370 380 390 400 410 420
pF1KB0 YA
XP_011 GV
430
>>XP_016874041 (OMIM: 604654) PREDICTED: 5-hydroxytrypta (372 aa)
initn: 1148 init1: 613 opt: 996 Z-score: 1056.0 bits: 204.4 E(85289): 4.4e-52
Smith-Waterman score: 1106; 41.5% identity (71.0% similar) in 407 aa overlap (73-475:2-369)
50 60 70 80 90 100
pF1KB0 TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDF
.: .::.: : .::.. :.::::.:: :
XP_016 MMDAENQILKTSVWYQEVWNDEFLSWNSSMF
10 20 30
110 120 130 140 150 160
pF1KB0 DNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIY
:.: ..:.: ..::.:::.::::::. . :..::::. .: ..::::.:::.::::. :
XP_016 DEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETY
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB0 NFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFS
:::::::::::: : :::..:..... : :: .. :...:.:..:::::.: . ..
XP_016 AFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB0 MESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLL
:.. .:...: ::.::.:: ::::::.::::::..:. .:::::: :. :: ..:.
XP_016 -SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLV
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB0 GYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVH-KQDLQQPVPA
::.:: . .:. .: .. .::::: .:..:::.::.:::..: .:...: .: : :
XP_016 GYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP-
220 230 240 250 260
350 360 370 380 390
pF1KB0 WLRHLVLERIAWLLCLREQSTSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSP
.:::: .. ..:: : ...:. :.. : .:.: .. : ..
XP_016 ------------FLCLRGDTDADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE-----
270 280 290 300 310
400 410 420 430 440 450
pF1KB0 RDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYL
. ..:.:: ..:. .:. . .:: . : .:.:::. ::
XP_016 -------------------VWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYL
320 330 340 350
460 470
pF1KB0 LAVLAYSITLVMLWSIWQYA
. . :.::: ::..:
XP_016 FMLGIYTITLCSLWALWGGV
360 370
>>NP_001243542 (OMIM: 610123) 5-hydroxytryptamine recept (456 aa)
initn: 1008 init1: 706 opt: 957 Z-score: 1013.6 bits: 196.9 E(85289): 1e-49
Smith-Waterman score: 1019; 39.0% identity (70.2% similar) in 433 aa overlap (46-473:51-455)
20 30 40 50 60 70
pF1KB0 TLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDE
:: ::: . :: :.:. . :::.:.:
NP_001 LQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNE
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB0 KNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIP
. ..:....: .. : . :..::::. ..:::.:. . ..:.:::.: :..:: :.:.
NP_001 QLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGL
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB0 YVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQ----DINISLWR
.:. ..:... ::..: . :.:::. :::: :::.:::.:.:.:.. :.. .:.
NP_001 TAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWE
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB0 LPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLL
. . ..:......:::::::. ..: ...: : .. :::.::::: .::..::.
NP_001 ITD---ASRNILQTHGEWELLGLSKATAKLS-RGGNLYDQIVFYVAIRRRPSLYVINLLV
210 220 230 240 250
260 270 280 290 300 310
pF1KB0 PSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVV
:: ::...: ..:::: .::.:: :::::::::.:::...:: ::.. :::::::::..
NP_001 PSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFAL
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB0 CMALLVISLAETIFIVRLVHKQDLQQP-VPAWLRHLVLERIAWLLCLREQSTSQRPPATS
:..:.: :: :::::..:.: : : .: ::. :.:. : .: .. :..
NP_001 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLH------C---NSPGRCCPTAP
320 330 340 350 360
380 390 400 410 420 430
pF1KB0 QATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLE
: . .. : .:. : : :. . : : :: :. : . . :.
NP_001 QK----ENKGPGLTPTHLPGV----KEPEVSAGQMPGPAEAELT--GGSEWTRAQREHEA
370 380 390 400 410
440 450 460 470
pF1KB0 KRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
.... :. ::. . ..: .::..::: . . ::.. ::.
NP_001 QKQHSVEL---WLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
420 430 440 450
>>NP_872395 (OMIM: 610123) 5-hydroxytryptamine receptor (471 aa)
initn: 1039 init1: 706 opt: 957 Z-score: 1013.5 bits: 196.9 E(85289): 1e-49
Smith-Waterman score: 1019; 39.0% identity (70.2% similar) in 433 aa overlap (46-473:66-470)
20 30 40 50 60 70
pF1KB0 TLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDE
:: ::: . :: :.:. . :::.:.:
NP_872 TTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNE
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB0 KNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIP
. ..:....: .. : . :..::::. ..:::.:. . ..:.:::.: :..:: :.:.
NP_872 QLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGL
100 110 120 130 140 150
140 150 160 170 180 190
pF1KB0 YVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQ----DINISLWR
.:. ..:... ::..: . :.:::. :::: :::.:::.:.:.:.. :.. .:.
NP_872 TAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWE
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB0 LPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLL
. . ..:......:::::::. ..: ...: : .. :::.::::: .::..::.
NP_872 ITD---ASRNILQTHGEWELLGLSKATAKLS-RGGNLYDQIVFYVAIRRRPSLYVINLLV
220 230 240 250 260 270
260 270 280 290 300 310
pF1KB0 PSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVV
:: ::...: ..:::: .::.:: :::::::::.:::...:: ::.. :::::::::..
NP_872 PSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFAL
280 290 300 310 320
320 330 340 350 360 370
pF1KB0 CMALLVISLAETIFIVRLVHKQDLQQP-VPAWLRHLVLERIAWLLCLREQSTSQRPPATS
:..:.: :: :::::..:.: : : .: ::. :.:. : .: .. :..
NP_872 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLH------C---NSPGRCCPTAP
330 340 350 360 370 380
380 390 400 410 420 430
pF1KB0 QATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLE
: . .. : .:. : : :. . : : :: :. : . . :.
NP_872 QK----ENKGPGLTPTHLPGV----KEPEVSAGQMPGPAEAELT--GGSEWTRAQREHEA
390 400 410 420 430
440 450 460 470
pF1KB0 KRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
.... :. ::. . ..: .::..::: . . ::.. ::.
NP_872 QKQHSVEL---WLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
440 450 460 470
>>NP_570126 (OMIM: 610121) 5-hydroxytryptamine receptor (447 aa)
initn: 968 init1: 667 opt: 929 Z-score: 984.2 bits: 191.4 E(85289): 4.4e-48
Smith-Waterman score: 978; 37.6% identity (68.9% similar) in 431 aa overlap (46-473:51-446)
20 30 40 50 60 70
pF1KB0 TLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDE
::. :: .. :: :.:. . :::.::
NP_570 LQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDA
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB0 KNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIP
. :.::...:. : . :..:::.. .:.::.. ....:.:::.: : .:: ..:.
NP_570 QLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGL
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB0 YVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWR-LPE
.:: .:... ::..:.. :.:::. :::: :::..::.:.:.:.... ... . . :
NP_570 TAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWE
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB0 KVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSI
. ..:.:...::::::::. ..:: ..: : .. :::.::::: .:...::.::
NP_570 ITDTSRKVIQTQGEWELLGINKATPKMSM-GNNLYDQIMFYVAIRRRPSLYIINLLVPSS
210 220 230 240 250
260 270 280 290 300 310
pF1KB0 FLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMA
::...: ..:::: .: .:. :::::::::.:::....: :::. :::::.:::..:..
NP_570 FLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS--GTPLISVYFALCLS
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB0 LLVISLAETIFIVRLVHKQDLQQP-VPAWLRHLVLERIAWLLCLREQSTSQRPPATSQAT
:.:.:: ::.::. :.: : : .: ::. :.:. . : : : ....
NP_570 LMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCC--------PTAPQKGN
320 330 340 350 360
380 390 400 410 420 430
pF1KB0 KTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL-AVCGLLQELSSIRQFLEKR
: ..: .:. :: : : . . :::. . : . :..:
NP_570 K-----GLGLTLTHLPGP----KEPGELAGKKLGPRETEPDGGSGWTK-----TQLMEL-
370 380 390 400 410
440 450 460 470
pF1KB0 DEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
:.. . ..: :::..::: . . .:...::.
NP_570 ---------WVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT
420 430 440
>>NP_938055 (OMIM: 610123) 5-hydroxytryptamine receptor (441 aa)
initn: 933 init1: 575 opt: 856 Z-score: 907.1 bits: 177.1 E(85289): 8.6e-44
Smith-Waterman score: 942; 38.3% identity (67.2% similar) in 433 aa overlap (46-473:51-440)
20 30 40 50 60 70
pF1KB0 TLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDE
:: ::: . :: :.:. . :::.:
NP_938 LQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDV--
30 40 50 60 70
80 90 100 110 120 130
pF1KB0 KNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIP
: . :..::::. ..:::.:. . ..:.:::.: :..:: :.:.
NP_938 -------------VWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGL
80 90 100 110 120
140 150 160 170 180 190
pF1KB0 YVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQ----DINISLWR
.:. ..:... ::..: . :.:::. :::: :::.:::.:.:.:.. :.. .:.
NP_938 TAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWE
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB0 LPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLL
. . ..:......:::::::. ..: ...: : .. :::.::::: .::..::.
NP_938 ITD---ASRNILQTHGEWELLGLSKATAKLS-RGGNLYDQIVFYVAIRRRPSLYVINLLV
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB0 PSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVV
:: ::...: ..:::: .::.:: :::::::::.:::...:: ::.. :::::::::..
NP_938 PSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFAL
250 260 270 280 290
320 330 340 350 360 370
pF1KB0 CMALLVISLAETIFIVRLVHKQDLQQP-VPAWLRHLVLERIAWLLCLREQSTSQRPPATS
:..:.: :: :::::..:.: : : .: ::. :.:. : .: .. :..
NP_938 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLH------C---NSPGRCCPTAP
300 310 320 330 340 350
380 390 400 410 420 430
pF1KB0 QATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLE
: . .. : .:. : : :. . : : :: :. : . . :.
NP_938 QK----ENKGPGLTPTHLPGV----KEPEVSAGQMPGPAEAELT--GGSEWTRAQREHEA
360 370 380 390 400
440 450 460 470
pF1KB0 KRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
.... :. ::. . ..: .::..::: . . ::.. ::.
NP_938 QKQHSVEL---WLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
410 420 430 440
478 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 20:34:56 2016 done: Sat Nov 5 20:34:57 2016
Total Scan time: 9.790 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]