Result of FASTA (omim) for
pF1KB0417
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0417, 471 aa
1>>>pF1KB0417 471 - 471 aa - 471 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4215+/-0.000614; mu= 4.2204+/- 0.037
mean_var=393.8643+/-93.097, 0's: 0 Z-trim(113.9): 756 B-trim: 1041 in 1/50
Lambda= 0.064625
statistics sampled from 22595 (23528) to 22595 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.276), width: 16
Scan time: 8.850
The best scores are: opt bits E(85289)
NP_689862 (OMIM: 615153) mixed lineage kinase doma ( 471) 3083 302.7 1.5e-81
XP_005255891 (OMIM: 615153) PREDICTED: mixed linea ( 471) 3083 302.7 1.5e-81
XP_011521238 (OMIM: 615153) PREDICTED: mixed linea ( 293) 1789 181.7 2.4e-45
NP_001135969 (OMIM: 615153) mixed lineage kinase d ( 263) 1187 125.5 1.7e-28
NP_002410 (OMIM: 600050) mitogen-activated protein ( 847) 355 48.7 7.4e-05
XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081) 345 47.9 0.00016
NP_001271159 (OMIM: 600136) mitogen-activated prot (1104) 345 47.9 0.00016
NP_149132 (OMIM: 600136) mitogen-activated protein (1118) 345 48.0 0.00016
XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166) 345 48.0 0.00017
NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 339 47.3 0.00022
NP_057062 (OMIM: 613932,616117) serine/threonine-p ( 835) 326 46.0 0.00048
NP_055030 (OMIM: 147671) insulin receptor-related (1297) 326 46.3 0.00061
XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860) 313 44.8 0.0011
XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962) 313 44.9 0.0012
XP_011510844 (OMIM: 600600) PREDICTED: ephrin type ( 394) 302 43.3 0.0015
NP_009101 (OMIM: 604746) dual specificity testis-s ( 571) 299 43.2 0.0022
XP_006710350 (OMIM: 604746) PREDICTED: dual specif ( 571) 299 43.2 0.0022
XP_011538799 (OMIM: 604746) PREDICTED: dual specif ( 571) 299 43.2 0.0022
NP_001307729 (OMIM: 604746) dual specificity testi ( 488) 297 42.9 0.0023
NP_004432 (OMIM: 600600) ephrin type-B receptor 1 ( 984) 302 43.9 0.0025
XP_016861357 (OMIM: 600600) PREDICTED: ephrin type (1016) 302 43.9 0.0025
XP_016861356 (OMIM: 600600) PREDICTED: ephrin type (1032) 302 43.9 0.0025
XP_005264773 (OMIM: 179611) PREDICTED: ephrin type ( 918) 301 43.7 0.0025
XP_016861355 (OMIM: 600600) PREDICTED: ephrin type (1038) 302 43.9 0.0025
NP_690620 (OMIM: 601890) inactive tyrosine-protein ( 940) 301 43.7 0.0026
XP_011513068 (OMIM: 601890) PREDICTED: inactive ty ( 948) 301 43.7 0.0026
XP_005264772 (OMIM: 179611) PREDICTED: ephrin type ( 982) 301 43.8 0.0026
NP_005224 (OMIM: 179611) ephrin type-A receptor 3 ( 983) 301 43.8 0.0026
NP_690621 (OMIM: 601890) inactive tyrosine-protein (1014) 301 43.8 0.0027
NP_690619 (OMIM: 601890) inactive tyrosine-protein (1030) 301 43.8 0.0027
XP_011513067 (OMIM: 601890) PREDICTED: inactive ty (1038) 301 43.8 0.0027
NP_002812 (OMIM: 601890) inactive tyrosine-protein (1070) 301 43.8 0.0028
NP_001257327 (OMIM: 601890) inactive tyrosine-prot (1078) 301 43.8 0.0028
NP_065690 (OMIM: 263650,605706) receptor-interacti ( 784) 294 43.0 0.0037
XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387) 288 41.9 0.0037
XP_016870237 (OMIM: 108961,602875,615923,616255) P ( 579) 290 42.4 0.004
XP_016870239 (OMIM: 108961,602875,615923,616255) P ( 579) 290 42.4 0.004
XP_016870238 (OMIM: 108961,602875,615923,616255) P ( 579) 290 42.4 0.004
XP_011516197 (OMIM: 108961,602875,615923,616255) P ( 582) 290 42.4 0.004
XP_011541578 (OMIM: 176942) PREDICTED: tyrosine-pr ( 468) 287 42.0 0.0043
XP_016870235 (OMIM: 108961,602875,615923,616255) P ( 718) 290 42.5 0.0045
XP_016870236 (OMIM: 108961,602875,615923,616255) P ( 718) 290 42.5 0.0045
XP_011516193 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045
XP_016870234 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045
XP_005251536 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045
XP_011516194 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045
XP_011516195 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045
XP_011516192 (OMIM: 108961,602875,615923,616255) P ( 721) 290 42.5 0.0045
XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606) 288 42.2 0.0047
NP_001645 (OMIM: 311010) serine/threonine-protein ( 606) 288 42.2 0.0047
>>NP_689862 (OMIM: 615153) mixed lineage kinase domain-l (471 aa)
initn: 3083 init1: 3083 opt: 3083 Z-score: 1585.3 bits: 302.7 E(85289): 1.5e-81
Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
370 380 390 400 410 420
430 440 450 460 470
pF1KB0 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
430 440 450 460 470
>>XP_005255891 (OMIM: 615153) PREDICTED: mixed lineage k (471 aa)
initn: 3083 init1: 3083 opt: 3083 Z-score: 1585.3 bits: 302.7 E(85289): 1.5e-81
Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
370 380 390 400 410 420
430 440 450 460 470
pF1KB0 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
430 440 450 460 470
>>XP_011521238 (OMIM: 615153) PREDICTED: mixed lineage k (293 aa)
initn: 1789 init1: 1789 opt: 1789 Z-score: 935.3 bits: 181.7 E(85289): 2.4e-45
Smith-Waterman score: 1789; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:1-273)
10 20 30 40 50 60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
:::::::::::::::::::::::::::::::::
XP_011 AIVRQTFNKEIKTMKKFESPNILRIFGICIDETGYTIQKHLNSTEKSEAQTSW
250 260 270 280 290
310 320 330 340 350 360
pF1KB0 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
>>NP_001135969 (OMIM: 615153) mixed lineage kinase domai (263 aa)
initn: 1568 init1: 1168 opt: 1187 Z-score: 632.4 bits: 125.5 E(85289): 1.7e-28
Smith-Waterman score: 1187; 90.3% identity (93.2% similar) in 206 aa overlap (1-203:1-206)
10 20 30 40 50 60
pF1KB0 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL
130 140 150 160 170 180
190 200 210 220 230
pF1KB0 PP---KCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQA
: :: . ..:..: . ::
NP_001 ESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC
190 200 210 220 230 240
>--
initn: 381 init1: 381 opt: 381 Z-score: 226.2 bits: 50.4 E(85289): 7.3e-06
Smith-Waterman score: 381; 100.0% identity (100.0% similar) in 57 aa overlap (415-471:207-263)
390 400 410 420 430 440
pF1KB0 VFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREI
::::::::::::::::::::::::::::::
NP_001 RQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREI
180 190 200 210 220 230
450 460 470
pF1KB0 IDECRAHDPSVRPSVDEILKKLSTFSK
:::::::::::::::::::::::::::
NP_001 IDECRAHDPSVRPSVDEILKKLSTFSK
240 250 260
>>NP_002410 (OMIM: 600050) mitogen-activated protein kin (847 aa)
initn: 193 init1: 193 opt: 355 Z-score: 208.2 bits: 48.7 E(85289): 7.4e-05
Smith-Waterman score: 362; 27.2% identity (58.4% similar) in 298 aa overlap (181-466:106-376)
160 170 180 190 200 210
pF1KB0 LRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLR
:: : :. . : :.. :.. :
NP_002 AISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPC--EVASFQ--ELRLEEVIGI------
80 90 100 110 120
220 230 240 250 260 270
pF1KB0 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI
. . .:.: .. ::.:. .. .:... .. .: . . . :::. . ..:.
NP_002 -GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCL
130 140 150 160 170 180
280 290 300 310 320
pF1KB0 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLH-HS
.: :.. .:::: : : . : :.:. ::: : :::.. :: ..
NP_002 EE----PNLCLVMEYAAGGPLSRALA-------GRRVPPHVLVNWAVQIARGMHYLHCEA
190 200 210 220 230
330 340 350 360 370
pF1KB0 EAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTRE--KTDRVKST---AYLS
.: .: ..:.:.:. : .. .: .:: ..: .:: :: ..... :...
NP_002 LVPVIHRDLKSNNILLLQ--PIESDDME-HKTLKITDFGLAREWHKTTQMSAAGTYAWMA
240 250 260 270 280 290
380 390 400 410 420 430
pF1KB0 PQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCP
:. .. .. :...:::..:::. ::..:..: . . :::.. :. ::
NP_002 PEVIKASTFSKG--SDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP
300 310 320 330 340
440 450 460 470
pF1KB0 SELREIIDECRAHDPSVRPSVDEILKKLSTFSK
. ... .: :.:: ::. ::..:
NP_002 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFD
350 360 370 380 390 400
>>XP_005267740 (OMIM: 600136) PREDICTED: mitogen-activat (1081 aa)
initn: 202 init1: 174 opt: 345 Z-score: 202.1 bits: 47.9 E(85289): 0.00016
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)
160 170 180 190 200 210
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
:.:. : :. :: .:. : .
XP_005 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
. . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:.
XP_005 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
160 170 180 190 200 210
280 290 300 310 320
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
: :.. .:::. . : : ..:. :::. .:: : :::. :: .::
XP_005 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
220 230 240 250 260
330 340 350 360 370
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
: .: ..:::.:. : :. . .: . ... .: .:: .: ..... :..
XP_005 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
270 280 290 300 310
380 390 400 410 420 430
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
.:. .. ... :...:.:..:::. ::..::.: .. . ::... :. :
XP_005 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
320 330 340 350 360 370
440 450 460 470
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
: . .....: :: ::: .:: .:.:
XP_005 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
380 390 400 410 420 430
XP_005 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
440 450 460 470 480 490
>>NP_001271159 (OMIM: 600136) mitogen-activated protein (1104 aa)
initn: 202 init1: 174 opt: 345 Z-score: 202.0 bits: 47.9 E(85289): 0.00016
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)
160 170 180 190 200 210
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
:.:. : :. :: .:. : .
NP_001 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
. . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:.
NP_001 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
160 170 180 190 200 210
280 290 300 310 320
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
: :.. .:::. . : : ..:. :::. .:: : :::. :: .::
NP_001 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
220 230 240 250 260
330 340 350 360 370
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
: .: ..:::.:. : :. . .: . ... .: .:: .: ..... :..
NP_001 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
270 280 290 300 310
380 390 400 410 420 430
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
.:. .. ... :...:.:..:::. ::..::.: .. . ::... :. :
NP_001 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
320 330 340 350 360 370
440 450 460 470
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
: . .....: :: ::: .:: .:.:
NP_001 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
380 390 400 410 420 430
NP_001 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
440 450 460 470 480 490
>>NP_149132 (OMIM: 600136) mitogen-activated protein kin (1118 aa)
initn: 202 init1: 174 opt: 345 Z-score: 202.0 bits: 48.0 E(85289): 0.00016
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)
160 170 180 190 200 210
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
:.:. : :. :: .:. : .
NP_149 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
. . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:.
NP_149 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
160 170 180 190 200 210
280 290 300 310 320
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
: :.. .:::. . : : ..:. :::. .:: : :::. :: .::
NP_149 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
220 230 240 250 260
330 340 350 360 370
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
: .: ..:::.:. : :. . .: . ... .: .:: .: ..... :..
NP_149 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
270 280 290 300 310
380 390 400 410 420 430
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
.:. .. ... :...:.:..:::. ::..::.: .. . ::... :. :
NP_149 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
320 330 340 350 360 370
440 450 460 470
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
: . .....: :: ::: .:: .:.:
NP_149 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
380 390 400 410 420 430
NP_149 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
440 450 460 470 480 490
>>XP_011535090 (OMIM: 600136) PREDICTED: mitogen-activat (1166 aa)
initn: 202 init1: 174 opt: 345 Z-score: 201.8 bits: 48.0 E(85289): 0.00017
Smith-Waterman score: 352; 27.2% identity (59.1% similar) in 301 aa overlap (182-468:128-405)
160 170 180 190 200 210
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRE
:.:. : :. :: .:. : .
XP_011 QLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCY---PPIQLLEIDFAELTLEEIIGI--
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB0 NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID
. . .:.. . ::.:. .. .:. . .. .: : . .. :::. . :.:.
XP_011 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLK
160 170 180 190 200 210
280 290 300 310 320
pF1KB0 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLVLGA---ARGLYRLHHSEA
: :.. .:::. . : : ..:. :::. .:: : :::. :: .::
XP_011 E----PNLCLVMEFARGGPLNRVLS-------GKRIPPDILVNWAVQIARGMNYLH-DEA
220 230 240 250 260
330 340 350 360 370
pF1KB0 --PELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTRE--KTDRVKST---AYL
: .: ..:::.:. : :. . .: . ... .: .:: .: ..... :..
XP_011 IVPIIHRDLKSSNILILQ----KVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM
270 280 290 300 310
380 390 400 410 420 430
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
.:. .. ... :...:.:..:::. ::..::.: .. . ::... :. :
XP_011 APEVIRASMFSKG--SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC
320 330 340 350 360 370
440 450 460 470
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
: . .....: :: ::: .:: .:.:
XP_011 PEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF
380 390 400 410 420 430
XP_011 DQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQE
440 450 460 470 480 490
>>NP_002437 (OMIM: 600137) mitogen-activated protein kin (954 aa)
initn: 217 init1: 181 opt: 339 Z-score: 199.6 bits: 47.3 E(85289): 0.00022
Smith-Waterman score: 346; 26.4% identity (59.2% similar) in 299 aa overlap (182-466:84-357)
160 170 180 190 200 210
pF1KB0 RRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQE-QIKEIKKEQLSGSPWILLR
: .: .::: ..:.. :.. :
NP_002 GDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQ-LPQEIPFHELQLEEIIGV------
60 70 80 90 100
220 230 240 250 260 270
pF1KB0 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICI
. . .:.. .. ::.:. . . :.. . .: . . .. :::. . : :.
NP_002 -GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACL
110 120 130 140 150 160
280 290 300 310 320
pF1KB0 DETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRM---VLV---LGAARGLYRLHH-S
. ::.. .:::: . :.: ..: :.:. ::: . .:::. ::. .
NP_002 N----PPHLCLVMEYARGGALSRVLA-------GRRVPPHVLVNWAVQVARGMNYLHNDA
170 180 190 200 210
330 340 350 360 370
pF1KB0 EAPELHGKIRSSNFLVTQGYQVK-LAGFELRKTQTSMSLGTTRE--KTDRVKST---AYL
.: .: ..: :.:. .. . . :: :. :. .: .:: :: ..... :..
NP_002 PVPIIHRDLKSINILILEAIENHNLADTVLKITD----FGLAREWHKTTKMSAAGTYAWM
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB0 SPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDC
.:. .. . .. .:...:::..:::. ::..:.. .. . ::... :. :
NP_002 APEVIR--LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTC
280 290 300 310 320
440 450 460 470
pF1KB0 PSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
: . ....:: :: ::. :::.:
NP_002 PEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMF
330 340 350 360 370 380
471 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:45:36 2016 done: Sat Nov 5 18:45:38 2016
Total Scan time: 8.850 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]