Result of FASTA (omim) for
pF1KB0403
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0403, 465 aa
1>>>pF1KB0403 465 - 465 aa - 465 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3224+/-0.000582; mu= -11.4256+/- 0.034
mean_var=714.7871+/-162.000, 0's: 0 Z-trim(117.0): 640 B-trim: 555 in 1/57
Lambda= 0.047972
statistics sampled from 27845 (28644) to 27845 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.336), width: 16
Scan time: 9.970
The best scores are: opt bits E(85289)
NP_951009 (OMIM: 605069) MAP kinase-interacting se ( 465) 3180 236.2 1.5e-61
NP_060042 (OMIM: 605069) MAP kinase-interacting se ( 414) 2669 200.7 6.1e-51
XP_006711065 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 2027 156.3 1.5e-37
XP_006711064 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 2027 156.3 1.5e-37
XP_006711066 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 2027 156.3 1.5e-37
XP_006711063 (OMIM: 606724) PREDICTED: MAP kinase- ( 424) 2018 155.7 2.3e-37
NP_001129025 (OMIM: 606724) MAP kinase-interacting ( 424) 2018 155.7 2.3e-37
XP_016858145 (OMIM: 606724) PREDICTED: MAP kinase- ( 412) 2015 155.5 2.6e-37
XP_016858144 (OMIM: 606724) PREDICTED: MAP kinase- ( 412) 2015 155.5 2.6e-37
XP_016858142 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 1787 139.7 1.5e-32
XP_016858141 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 1787 139.7 1.5e-32
XP_016858143 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 1787 139.7 1.5e-32
XP_016858151 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 1783 139.3 1.6e-32
XP_016858150 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 1783 139.3 1.6e-32
XP_016858149 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 1783 139.3 1.6e-32
XP_006711070 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
XP_006711069 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
XP_006711072 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
XP_016858146 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
NP_945324 (OMIM: 606724) MAP kinase-interacting se ( 347) 1774 138.7 2.4e-32
XP_016858148 (OMIM: 606724) PREDICTED: MAP kinase- ( 347) 1774 138.7 2.4e-32
XP_016858152 (OMIM: 606724) PREDICTED: MAP kinase- ( 335) 1771 138.5 2.8e-32
XP_016858147 (OMIM: 606724) PREDICTED: MAP kinase- ( 350) 1543 122.7 1.6e-27
XP_016858154 (OMIM: 606724) PREDICTED: MAP kinase- ( 292) 1534 122.0 2.2e-27
XP_006711076 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
XP_006711078 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
XP_006711077 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
XP_016858153 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
NP_003675 (OMIM: 606724) MAP kinase-interacting se ( 465) 1322 107.6 7.5e-23
XP_016858155 (OMIM: 606724) PREDICTED: MAP kinase- ( 252) 1238 101.4 3e-21
XP_016858156 (OMIM: 606724) PREDICTED: MAP kinase- ( 252) 1238 101.4 3e-21
XP_016858157 (OMIM: 606724) PREDICTED: MAP kinase- ( 243) 775 69.3 1.3e-11
NP_003659 (OMIM: 606723) MAP kinase-activated prot ( 471) 545 53.8 1.2e-06
NP_620777 (OMIM: 606723) MAP kinase-activated prot ( 473) 545 53.8 1.2e-06
XP_016875620 (OMIM: 606723) PREDICTED: MAP kinase- ( 378) 505 50.9 7e-06
XP_016875618 (OMIM: 606723) PREDICTED: MAP kinase- ( 380) 505 50.9 7.1e-06
XP_016875619 (OMIM: 606723) PREDICTED: MAP kinase- ( 380) 505 50.9 7.1e-06
XP_016875616 (OMIM: 606723) PREDICTED: MAP kinase- ( 386) 505 50.9 7.1e-06
XP_016875617 (OMIM: 606723) PREDICTED: MAP kinase- ( 386) 505 50.9 7.1e-06
XP_016875614 (OMIM: 606723) PREDICTED: MAP kinase- ( 405) 505 51.0 7.3e-06
NP_001287731 (OMIM: 603606) ribosomal protein S6 k ( 765) 431 46.3 0.00036
XP_016874016 (OMIM: 603606) PREDICTED: ribosomal p ( 398) 423 45.3 0.00037
NP_001006945 (OMIM: 603606) ribosomal protein S6 k ( 766) 424 45.8 0.0005
NP_001305290 (OMIM: 603606) ribosomal protein S6 k ( 709) 423 45.7 0.00051
XP_005274437 (OMIM: 603606) PREDICTED: ribosomal p ( 717) 423 45.7 0.00051
NP_003933 (OMIM: 603606) ribosomal protein S6 kina ( 772) 423 45.7 0.00053
NP_006733 (OMIM: 177015) serine/threonine-protein ( 424) 407 44.2 0.00082
XP_016873652 (OMIM: 607670) PREDICTED: serine/thre ( 378) 403 43.9 0.00094
XP_016873653 (OMIM: 607670) PREDICTED: serine/thre ( 378) 403 43.9 0.00094
XP_016873651 (OMIM: 607670) PREDICTED: serine/thre ( 378) 403 43.9 0.00094
>>NP_951009 (OMIM: 605069) MAP kinase-interacting serine (465 aa)
initn: 3180 init1: 3180 opt: 3180 Z-score: 1226.2 bits: 236.2 E(85289): 1.5e-61
Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 465 aa overlap (1-465:1-465)
10 20 30 40 50 60
pF1KB0 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
370 380 390 400 410 420
430 440 450 460
pF1KB0 QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
:::::::::::::::::::::::::::::::::::::::::::::
NP_951 QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
430 440 450 460
>>NP_060042 (OMIM: 605069) MAP kinase-interacting serine (414 aa)
initn: 2669 init1: 2669 opt: 2669 Z-score: 1035.6 bits: 200.7 E(85289): 6.1e-51
Smith-Waterman score: 2669; 100.0% identity (100.0% similar) in 385 aa overlap (1-385:1-385)
10 20 30 40 50 60
pF1KB0 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
:::::::::::::::::::::::::
NP_060 QVLQHPWVQGCAPENTLPTPMVLQRWDSHFLLPPHPCRIHVRPGGLVRTVTVNE
370 380 390 400 410
>>XP_006711065 (OMIM: 606724) PREDICTED: MAP kinase-inte (418 aa)
initn: 2033 init1: 1977 opt: 2027 Z-score: 795.4 bits: 156.3 E(85289): 1.5e-37
Smith-Waterman score: 2027; 72.6% identity (89.0% similar) in 409 aa overlap (46-451:5-404)
20 30 40 50 60 70
pF1KB0 FKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSF
:.: .:.:. : :. .: :::.:::::::.
XP_006 MQNIPEMGSSEPLPIADGDRRRKKKRRGRATDSL
10 20 30
80 90 100 110 120 130
pF1KB0 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ
:.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :::
XP_006 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF
:::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::
XP_006 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE
::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::
XP_006 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ
::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::
XP_006 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPEN
: ::::::::::::::::::::: :::::::::::::::::::::::::::::: :::.
XP_006 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 TLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC
::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..: :
XP_006 GLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------C
340 350 360 370 380
440 450 460
pF1KB0 -LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
..:::: .:.::.:: :
XP_006 SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
390 400 410
>>XP_006711064 (OMIM: 606724) PREDICTED: MAP kinase-inte (418 aa)
initn: 2033 init1: 1977 opt: 2027 Z-score: 795.4 bits: 156.3 E(85289): 1.5e-37
Smith-Waterman score: 2027; 72.6% identity (89.0% similar) in 409 aa overlap (46-451:5-404)
20 30 40 50 60 70
pF1KB0 FKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSF
:.: .:.:. : :. .: :::.:::::::.
XP_006 MQNIPEMGSSEPLPIADGDRRRKKKRRGRATDSL
10 20 30
80 90 100 110 120 130
pF1KB0 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ
:.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :::
XP_006 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF
:::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::
XP_006 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE
::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::
XP_006 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ
::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::
XP_006 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPEN
: ::::::::::::::::::::: :::::::::::::::::::::::::::::: :::.
XP_006 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 TLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC
::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..: :
XP_006 GLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------C
340 350 360 370 380
440 450 460
pF1KB0 -LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
..:::: .:.::.:: :
XP_006 SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
390 400 410
>>XP_006711066 (OMIM: 606724) PREDICTED: MAP kinase-inte (418 aa)
initn: 2033 init1: 1977 opt: 2027 Z-score: 795.4 bits: 156.3 E(85289): 1.5e-37
Smith-Waterman score: 2027; 72.6% identity (89.0% similar) in 409 aa overlap (46-451:5-404)
20 30 40 50 60 70
pF1KB0 FKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSF
:.: .:.:. : :. .: :::.:::::::.
XP_006 MQNIPEMGSSEPLPIADGDRRRKKKRRGRATDSL
10 20 30
80 90 100 110 120 130
pF1KB0 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ
:.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :::
XP_006 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF
:::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::
XP_006 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE
::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::
XP_006 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ
::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::
XP_006 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPEN
: ::::::::::::::::::::: :::::::::::::::::::::::::::::: :::.
XP_006 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 TLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC
::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..: :
XP_006 GLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------C
340 350 360 370 380
440 450 460
pF1KB0 -LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
..:::: .:.::.:: :
XP_006 SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
390 400 410
>>XP_006711063 (OMIM: 606724) PREDICTED: MAP kinase-inte (424 aa)
initn: 2023 init1: 1967 opt: 2018 Z-score: 792.0 bits: 155.7 E(85289): 2.3e-37
Smith-Waterman score: 2018; 72.3% identity (88.8% similar) in 411 aa overlap (45-451:9-410)
20 30 40 50 60 70
pF1KB0 SFKGQNPFELAFSLDQPDHGDSDFGLQCSARP-DMPASQPIDIPDAKKRGKKKKRGRATD
.: .: .:.:. : :. .: :::.::::::
XP_006 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATD
10 20 30
80 90 100 110 120 130
pF1KB0 SFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEML
:. :.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :
XP_006 SLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 YQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASAL
:::::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::
XP_006 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 DFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGS
::::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::
XP_006 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 AEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPA
::::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .
XP_006 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 CQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAP
::: ::::::::::::::::::::: :::::::::::::::::::::::::::::: ::
XP_006 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 ENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATS
:. ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:
XP_006 EKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL--------
340 350 360 370 380 390
440 450 460
pF1KB0 RC-LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
: ..:::: .:.::.:: :
XP_006 -CSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
400 410 420
>>NP_001129025 (OMIM: 606724) MAP kinase-interacting ser (424 aa)
initn: 2023 init1: 1967 opt: 2018 Z-score: 792.0 bits: 155.7 E(85289): 2.3e-37
Smith-Waterman score: 2018; 72.3% identity (88.8% similar) in 411 aa overlap (45-451:9-410)
20 30 40 50 60 70
pF1KB0 SFKGQNPFELAFSLDQPDHGDSDFGLQCSARP-DMPASQPIDIPDAKKRGKKKKRGRATD
.: .: .:.:. : :. .: :::.::::::
NP_001 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATD
10 20 30
80 90 100 110 120 130
pF1KB0 SFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEML
:. :.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :
NP_001 SLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 YQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASAL
:::::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::
NP_001 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 DFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGS
::::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::
NP_001 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 AEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPA
::::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .
NP_001 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 CQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAP
::: ::::::::::::::::::::: :::::::::::::::::::::::::::::: ::
NP_001 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 ENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATS
:. ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:
NP_001 EKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL--------
340 350 360 370 380 390
440 450 460
pF1KB0 RC-LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
: ..:::: .:.::.:: :
NP_001 -CSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
400 410 420
>>XP_016858145 (OMIM: 606724) PREDICTED: MAP kinase-inte (412 aa)
initn: 2021 init1: 1965 opt: 2015 Z-score: 791.0 bits: 155.5 E(85289): 2.6e-37
Smith-Waterman score: 2015; 72.7% identity (88.9% similar) in 407 aa overlap (48-451:1-398)
20 30 40 50 60 70
pF1KB0 GQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSG
: .:.:. : :. .: :::.:::::::. :
XP_016 MGSSEPLPIADGDRRRKKKRRGRATDSLPG
10 20 30
80 90 100 110 120 130
pF1KB0 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ
.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :::::
XP_016 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH
:..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::::
XP_016 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 NKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYM
.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::::
XP_016 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM
::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .:::
XP_016 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNK
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL
::::::::::::::::::::: :::::::::::::::::::::::::::::: :::. :
XP_016 LFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 PTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC-L
:::.:::::: . ::: :::::::.::::.::.:. :::: :: ..: : .
XP_016 PTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------CSM
340 350 360 370 380
440 450 460
pF1KB0 QLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
.:::: .:.::.:: :
XP_016 KLSPPCKSRLARRRALAQAGRGEDRSPPTAL
390 400 410
>>XP_016858144 (OMIM: 606724) PREDICTED: MAP kinase-inte (412 aa)
initn: 2021 init1: 1965 opt: 2015 Z-score: 791.0 bits: 155.5 E(85289): 2.6e-37
Smith-Waterman score: 2015; 72.7% identity (88.9% similar) in 407 aa overlap (48-451:1-398)
20 30 40 50 60 70
pF1KB0 GQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSG
: .:.:. : :. .: :::.:::::::. :
XP_016 MGSSEPLPIADGDRRRKKKRRGRATDSLPG
10 20 30
80 90 100 110 120 130
pF1KB0 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ
.:::.:.: ..:::::.:.:: ..: ...:::::::::: :: ::::::::: :::::
XP_016 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB0 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH
:..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::::
XP_016 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB0 NKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYM
.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::::
XP_016 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB0 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM
::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .:::
XP_016 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNK
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB0 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL
::::::::::::::::::::: :::::::::::::::::::::::::::::: :::. :
XP_016 LFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB0 PTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC-L
:::.:::::: . ::: :::::::.::::.::.:. :::: :: ..: : .
XP_016 PTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------CSM
340 350 360 370 380
440 450 460
pF1KB0 QLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
.:::: .:.::.:: :
XP_016 KLSPPCKSRLARRRALAQAGRGEDRSPPTAL
390 400 410
>>XP_016858142 (OMIM: 606724) PREDICTED: MAP kinase-inte (427 aa)
initn: 1806 init1: 1728 opt: 1787 Z-score: 705.5 bits: 139.7 E(85289): 1.5e-32
Smith-Waterman score: 1787; 69.0% identity (84.6% similar) in 397 aa overlap (60-451:28-413)
30 40 50 60 70 80
pF1KB0 QPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFS--GRFEDVYQLQE
::. .:::. .: :. :. . .
XP_016 MPPDPLRREWAFPLNGQRTSFHFKSSQKKKKEKKKKTPTTKSLCLLKRWAVANPFPS
10 20 30 40 50
90 100 110 120 130 140
pF1KB0 DVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIE
... :.. : : :: ..:::::: :: ::::::::: ::::::..:.:::::
XP_016 QMVTGGGR-RSGGAGPLTPCQE-SLKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE
60 70 80 90 100 110
150 160 170 180 190 200
pF1KB0 FFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLK
:::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::::.:::::::::
XP_016 FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLK
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB0 PENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSE
::::::: :..::::::::::::::.:::..:.::.:::: :::::::::::::::.:..
XP_016 PENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTD
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB0 EASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKY
.:..::::::::::::.:::.:::::::::.::.::::::::.: .::: ::::::::::
XP_016 QATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKY
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB0 EFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNS
::::::::::: :::::::::::::::::::::::::::::: :::. ::::.::::::
XP_016 EFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNS
300 310 320 330 340 350
390 400 410 420 430 440
pF1KB0 CAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC-LQLSPPSQSKL
. ::: :::::::.::::.::.:. :::: :: ..: : ..:::: .:.:
XP_016 STMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------CSMKLSPPCKSRL
360 370 380 390 400
450 460
pF1KB0 AQRRQRASLSSAPVVLVGDHA
:.:: :
XP_016 ARRRALAQAGRGEDRSPPTAL
410 420
465 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 16:45:33 2016 done: Sat Nov 5 16:45:35 2016
Total Scan time: 9.970 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]