Result of FASTA (omim) for
pF1KA1838
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1838, 910 aa
1>>>pF1KA1838 910 - 910 aa - 910 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2644+/-0.000501; mu= 11.7157+/- 0.031
mean_var=131.3308+/-27.142, 0's: 0 Z-trim(112.2): 101 B-trim: 14 in 1/53
Lambda= 0.111916
statistics sampled from 20882 (20978) to 20882 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.595), E-opt: 0.2 (0.246), width: 16
Scan time: 9.980
The best scores are: opt bits E(85289)
NP_115824 (OMIM: 612266) constitutive coactivator ( 910) 6287 1027.7 0
NP_001273308 (OMIM: 612266) constitutive coactivat ( 922) 6287 1027.7 0
NP_001273309 (OMIM: 612266) constitutive coactivat ( 933) 6287 1027.7 0
XP_016866849 (OMIM: 612266) PREDICTED: constitutiv ( 705) 4648 763.0 0
XP_016866848 (OMIM: 612266) PREDICTED: constitutiv ( 706) 4648 763.0 0
XP_016866847 (OMIM: 612266) PREDICTED: constitutiv ( 716) 4648 763.0 0
XP_011534487 (OMIM: 612266) PREDICTED: constitutiv ( 673) 4632 760.4 0
NP_001273310 (OMIM: 612266) constitutive coactivat ( 242) 1682 283.9 6.7e-76
XP_016866846 (OMIM: 612266) PREDICTED: constitutiv ( 358) 1404 239.1 3e-62
XP_011516718 (OMIM: 612265) PREDICTED: constitutiv ( 796) 460 86.9 4.4e-16
XP_011516716 (OMIM: 612265) PREDICTED: constitutiv (1145) 460 87.0 5.9e-16
XP_011516715 (OMIM: 612265) PREDICTED: constitutiv (1145) 460 87.0 5.9e-16
XP_011516714 (OMIM: 612265) PREDICTED: constitutiv (1146) 460 87.0 5.9e-16
NP_001273653 (OMIM: 612265) constitutive coactivat ( 628) 376 73.2 4.4e-12
NP_001273652 (OMIM: 612265) constitutive coactivat ( 651) 376 73.3 4.5e-12
NP_001273651 (OMIM: 612265) constitutive coactivat (1117) 376 73.4 7e-12
XP_005251899 (OMIM: 612265) PREDICTED: constitutiv (1117) 376 73.4 7e-12
NP_055427 (OMIM: 612265) constitutive coactivator (1118) 376 73.4 7e-12
XP_006724652 (OMIM: 300741) PREDICTED: constitutiv ( 957) 330 65.9 1.1e-09
NP_060318 (OMIM: 300741) constitutive coactivator (1096) 330 66.0 1.2e-09
XP_005259549 (OMIM: 601869,608792) PREDICTED: PDZ (1349) 204 45.7 0.0019
>>NP_115824 (OMIM: 612266) constitutive coactivator of p (910 aa)
initn: 6287 init1: 6287 opt: 6287 Z-score: 5493.6 bits: 1027.7 E(85289): 0
Smith-Waterman score: 6287; 99.9% identity (99.9% similar) in 910 aa overlap (1-910:1-910)
10 20 30 40 50 60
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVKEWFVYPGNPLRH
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_115 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 CCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 TTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 KAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSR
850 860 870 880 890 900
910
pF1KA1 QYEHDQWRRY
::::::::::
NP_115 QYEHDQWRRY
910
>>NP_001273308 (OMIM: 612266) constitutive coactivator o (922 aa)
initn: 6287 init1: 6287 opt: 6287 Z-score: 5493.5 bits: 1027.7 E(85289): 0
Smith-Waterman score: 6287; 99.9% identity (99.9% similar) in 910 aa overlap (1-910:13-922)
10 20 30 40
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCC
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDRQMILSRSSVMGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCC
10 20 30 40 50 60
50 60 70 80 90 100
pF1KA1 LRYWYTPESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRYWYTPESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KA1 NREISRIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NREISRIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KA1 QHNCLGILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHNCLGILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KA1 LGNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEIL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA1 PLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA1 SRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPE
370 380 390 400 410 420
410 420 430 440 450 460
pF1KA1 PRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPE
430 440 450 460 470 480
470 480 490 500 510 520
pF1KA1 SRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEI
490 500 510 520 530 540
530 540 550 560 570 580
pF1KA1 NQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAE
550 560 570 580 590 600
590 600 610 620 630 640
pF1KA1 SYLVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVK
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 SYLVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KA1 EWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSRE
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA1 ELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPR
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA1 AVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLE
790 800 810 820 830 840
830 840 850 860 870 880
pF1KA1 QNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQ
850 860 870 880 890 900
890 900 910
pF1KA1 GQPWRDQGPGSRQYEHDQWRRY
::::::::::::::::::::::
NP_001 GQPWRDQGPGSRQYEHDQWRRY
910 920
>>NP_001273309 (OMIM: 612266) constitutive coactivator o (933 aa)
initn: 6287 init1: 6287 opt: 6287 Z-score: 5493.4 bits: 1027.7 E(85289): 0
Smith-Waterman score: 6287; 99.9% identity (99.9% similar) in 910 aa overlap (1-910:24-933)
10 20 30
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGC
:::::::::::::::::::::::::::::::::::::
NP_001 MFGPRGSTSAGAGRKEILSRSSVMGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGC
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA1 TPTIVVDAMCCLRYWYTPESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTIVVDAMCCLRYWYTPESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 RDEWVKRRLKNNREISRIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEWVKRRLKNNREISRIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 EADYEVASYGLQHNCLGILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADYEVASYGLQHNCLGILGEDTDYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGL
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 CVADLPLLACLLGNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVADLPLLACLLGNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 YQGEKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQGEKKLEEILPLGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAES
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 REEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REEVPMCSDAESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPES
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 RREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RREVPMCSDPEPRQEVPMCTGPEARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEP
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 RQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQEVPMYTGPESRQEVPMYTGPESRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISK
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 QEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEIL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA1 KVARTHHVQAESYLVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_001 KVARTHHVQAESYLVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDC
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA1 QDVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTL
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 LACFNLSSSREELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LACFNLSSSREELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 VNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQS
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA1 EKGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYH
850 860 870 880 890 900
880 890 900 910
pF1KA1 RTGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
:::::::::::::::::::::::::::::::::
NP_001 RTGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
910 920 930
>>XP_016866849 (OMIM: 612266) PREDICTED: constitutive co (705 aa)
initn: 4648 init1: 4648 opt: 4648 Z-score: 4065.0 bits: 763.0 E(85289): 0
Smith-Waterman score: 4648; 99.9% identity (99.9% similar) in 674 aa overlap (1-674:1-674)
10 20 30 40 50 60
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVKEWFVYPGNPLRH
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
::::::::::::::
XP_016 PDLVRPLQMTIPGGHALPGGFACVYCAGLVPPRKIHLAACKSTEI
670 680 690 700
>>XP_016866848 (OMIM: 612266) PREDICTED: constitutive co (706 aa)
initn: 4648 init1: 4648 opt: 4648 Z-score: 4065.0 bits: 763.0 E(85289): 0
Smith-Waterman score: 4648; 99.9% identity (99.9% similar) in 674 aa overlap (1-674:1-674)
10 20 30 40 50 60
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVKEWFVYPGNPLRH
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
::::::::::::::
XP_016 PDLVRPLQMTIPGGHALPGGFACVYCAGLVPPRKIHLAACKSTVEI
670 680 690 700
>>XP_016866847 (OMIM: 612266) PREDICTED: constitutive co (716 aa)
initn: 4648 init1: 4648 opt: 4648 Z-score: 4064.9 bits: 763.0 E(85289): 0
Smith-Waterman score: 4648; 99.9% identity (99.9% similar) in 674 aa overlap (1-674:1-674)
10 20 30 40 50 60
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVKEWFVYPGNPLRH
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
::::::::::::::
XP_016 PDLVRPLQMTIPGGHALPGGFACVYCAGLVPPRKIHLAACKSTEAVIEFRSFKNCV
670 680 690 700 710
>>XP_011534487 (OMIM: 612266) PREDICTED: constitutive co (673 aa)
initn: 4632 init1: 4632 opt: 4632 Z-score: 4051.3 bits: 760.4 E(85289): 0
Smith-Waterman score: 4632; 99.9% identity (99.9% similar) in 672 aa overlap (1-672:1-672)
10 20 30 40 50 60
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVKEWFVYPGNPLRH
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_011 IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
::::::::::::
XP_011 PDLVRPLQMTIPA
670
>>NP_001273310 (OMIM: 612266) constitutive coactivator o (242 aa)
initn: 1682 init1: 1682 opt: 1682 Z-score: 1483.6 bits: 283.9 E(85289): 6.7e-76
Smith-Waterman score: 1682; 100.0% identity (100.0% similar) in 242 aa overlap (669-910:1-242)
640 650 660 670 680 690
pF1KA1 DVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLL
::::::::::::::::::::::::::::::
NP_001 MTIPGGTPSLKILWLNQEPEIQVRRLDTLL
10 20 30
700 710 720 730 740 750
pF1KA1 ACFNLSSSREELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACFNLSSSREELQAVESPFQALCCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLV
40 50 60 70 80 90
760 770 780 790 800 810
pF1KA1 NLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLQPDYINPRAVQLGSLLVRGLTTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSE
100 110 120 130 140 150
820 830 840 850 860 870
pF1KA1 KGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHR
160 170 180 190 200 210
880 890 900 910
pF1KA1 TGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
::::::::::::::::::::::::::::::::
NP_001 TGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
220 230 240
>>XP_016866846 (OMIM: 612266) PREDICTED: constitutive co (358 aa)
initn: 1555 init1: 1396 opt: 1404 Z-score: 1238.6 bits: 239.1 E(85289): 3e-62
Smith-Waterman score: 2388; 91.8% identity (91.8% similar) in 389 aa overlap (522-910:1-358)
500 510 520 530 540 550
pF1KA1 ESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPE
::::::::::::::::::::::::::::::
XP_016 MCTHAEINQKLPVATDFEFKLEALMCTNPE
10 20 30
560 570 580 590 600 610
pF1KA1 IKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGEIECSNTLEDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGEIECSNTLEDEL
40 50 60 70 80 90
620 630 640 650 660 670
pF1KA1 DQALPSQAFIYRPIRQRVYSLLLGDCQDVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTI
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 DQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRHPDLVRPLQMTI
100 110 120 130 140 150
680 690 700 710 720 730
pF1KA1 PGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQALCCLLIYLFVQV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQALCCLLIYLFVQ-
160 170 180 190 200
740 750 760 770 780 790
pF1KA1 DTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGLTTLVLVNSACG
::::::::::::::::::::::::::::::
XP_016 ------------------------------PDYINPRAVQLGSLLVRGLTTLVLVNSACG
210 220 230
800 810 820 830 840 850
pF1KA1 FPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNLKAVVCKACMKE
240 250 260 270 280 290
860 870 880 890 900 910
pF1KA1 NRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSRQYEHDQWRRY
300 310 320 330 340 350
>>XP_011516718 (OMIM: 612265) PREDICTED: constitutive co (796 aa)
initn: 515 init1: 231 opt: 460 Z-score: 409.8 bits: 86.9 E(85289): 4.4e-16
Smith-Waterman score: 619; 23.7% identity (53.0% similar) in 815 aa overlap (1-761:1-786)
10 20 30 40 50
pF1KA1 MGVRGLQGFVGSTCPHICTVVNFKELAEHH-----RSKYPGCTPTIVVDAMCCLRYWYTP
:::.:.: .. . :: . :....::. :.. : ..::: ::. :
XP_011 MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 --ESWICGGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREIS
.:. :::: .... : ..:. ...:.:. ::.: .:. . :::::. .. . .
XP_011 FYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 RIFHYIKSHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCL
.: ..... : . :. : .: :.:: . .. :... :: .. ...
XP_011 QIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
130 140 150 160 170 180
180 190 200 210 220
pF1KA1 GILGEDTDYLIYDTCPYFSISELCL----ESLDTVMLCREKLCESLGLCVADLPLLACLL
:... :.:: . . ::: : : .:: : . ... ..: : .:..: ::
XP_011 GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KA1 GNDIIPEGMFESFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILP
:: :.:. . ::... :. . . ...: : . :.. : .....
XP_011 GNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYV--RNIQDTSD
250 260 270 280 290
290 300 310 320 330 340
pF1KA1 LGPNKALFYKGMASYLLPGQKSPWFFQKPKGVITLDKQV--ISTSSDAESREEVPMCSDA
: ..:. .. ..: . :: . . . :..: : . . .
XP_011 LD--------AIAKDVFQHSQS----RTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAAR
300 310 320 330 340
350 360 370 380 390 400
pF1KA1 ESRQEVPMCTGPESRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMC-SD
. .: . :. :: . : .. . . : : ::. : .. :. :.
XP_011 PGPFGMPGMVPPH----VPPQMLNIP--QTSLQAKPVAPQ-VPSPGGAPGQGPYPYSLSE
350 360 370 380 390
410 420 430 440 450 460
pF1KA1 PEPRQEVPMCTGPEARQEVPMYTD-SEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYT
: : . . :. . : :.. . ...:.: : : . : .:: . . ..
XP_011 PAP---LTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPIN--PAQSGSPNHVDSAYFP
400 410 420 430 440 450
470 480 490 500 510
pF1KA1 GPE--SRQEVPMYTGPESRQ-EVLIRTDPESRQE---IMCT-----GHESKQEVPIC---
: : .. .: .. .. .. . ..: ..:. :: : ...
XP_011 GSSTSSSSDNDEGSGGATKPFQLYLQKNFVFHKENSIVLCSRILRHGHISGNKIGWEKTG
460 470 480 490 500 510
520 530 540 550 560
pF1KA1 --TDPISKQEDSMCTHAEINQKLPVATDFEFKLEALMCTNPEIK--QEDPTNVGPEVKQQ
..: .. . . :.:: .. .... . : : : :: ..
XP_011 SHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTP
520 530 540 550 560 570
570 580 590 600 610 620
pF1KA1 VTMVSDTEILKVARTHHVQAESY-LVYNIMSSGEIECSNTLEDELDQALPSQAFIYRPIR
:.:.::. .: .. : .......:::. . ..::: .. :: :..:::.:
XP_011 PLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVR
580 590 600 610 620 630
630 640 650 660 670
pF1KA1 QRVYSLLLGDCQDVTSTC-LA--------------VKEWFVYPGNPLRHPDLVRPLQMTI
: ::..:.. .. .: :: .::: .: :. . :.::. : .
XP_011 QYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFR-
640 650 660 670 680 690
680 690 700 710 720
pF1KA1 PGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESP--FQALCCLLIYLFV
:.:: :::.. : . ::. ..:::. :.. :. .. : ...:::.: :. :
XP_011 EWTCPNLKRLWLGKAVEDKNRRMRAFLACMR-SDTPAMLNPANVPTHLMVLCCVLRYM-V
700 710 720 730 740 750
730 740 750 760 770 780
pF1KA1 Q---VDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGLTTLVLV
: . : ..: ::.:::: . .:: .:.
XP_011 QWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIITSVLTSQF
760 770 780 790
790 800 810 820 830 840
pF1KA1 NSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNLKAVVCK
910 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 22:06:06 2016 done: Wed Nov 2 22:06:07 2016
Total Scan time: 9.980 Total Display time: 0.200
Function used was FASTA [36.3.4 Apr, 2011]