Result of FASTA (omim) for
pF1KA1507
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1507, 922 aa
1>>>pF1KA1507 922 - 922 aa - 922 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1811+/-0.000394; mu= 23.0462+/- 0.025
mean_var=90.0326+/-18.360, 0's: 0 Z-trim(113.2): 16 B-trim: 20 in 1/52
Lambda= 0.135168
statistics sampled from 22379 (22390) to 22379 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.263), width: 16
Scan time: 12.920
The best scores are: opt bits E(85289)
NP_060390 (OMIM: 610337) up-regulator of cell prol ( 922) 6210 1222.1 0
NP_001071131 (OMIM: 610337) up-regulator of cell p ( 931) 6183 1216.8 0
NP_001277005 (OMIM: 610337) up-regulator of cell p ( 888) 5989 1178.9 0
NP_001277004 (OMIM: 610337) up-regulator of cell p ( 888) 5989 1178.9 0
NP_001071132 (OMIM: 610337) up-regulator of cell p ( 888) 5989 1178.9 0
NP_115976 (OMIM: 609986) caspase recruitment domai (1037) 708 149.2 1e-34
XP_016865479 (OMIM: 609986) PREDICTED: caspase rec ( 743) 701 147.7 2.1e-34
XP_016865478 (OMIM: 609986) PREDICTED: caspase rec ( 851) 701 147.7 2.3e-34
>>NP_060390 (OMIM: 610337) up-regulator of cell prolifer (922 aa)
initn: 6210 init1: 6210 opt: 6210 Z-score: 6543.6 bits: 1222.1 E(85289): 0
Smith-Waterman score: 6210; 100.0% identity (100.0% similar) in 922 aa overlap (1-922:1-922)
10 20 30 40 50 60
pF1KA1 MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 RNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 FREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 YKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 RRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 EFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 PLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 MPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAF
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 MQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 AETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLEN
850 860 870 880 890 900
910 920
pF1KA1 IRNGLSNQNKNIQQLIELVRRL
::::::::::::::::::::::
NP_060 IRNGLSNQNKNIQQLIELVRRL
910 920
>>NP_001071131 (OMIM: 610337) up-regulator of cell proli (931 aa)
initn: 6183 init1: 6183 opt: 6183 Z-score: 6515.1 bits: 1216.8 E(85289): 0
Smith-Waterman score: 6183; 100.0% identity (100.0% similar) in 918 aa overlap (5-922:14-931)
10 20 30 40 50
pF1KA1 MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEA
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASPGIEVELLGKGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 QDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 KLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA1 VNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWW
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA1 SQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA1 GTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFI
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA1 LTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA1 STDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERIT
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA1 RKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQN
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA1 GHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTT
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA1 DVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA1 ELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATG
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA1 KSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA1 LSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KA1 PPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIF
850 860 870 880 890 900
900 910 920
pF1KA1 ELKRCLLENIRNGLSNQNKNIQQLIELVRRL
:::::::::::::::::::::::::::::::
NP_001 ELKRCLLENIRNGLSNQNKNIQQLIELVRRL
910 920 930
>>NP_001277005 (OMIM: 610337) up-regulator of cell proli (888 aa)
initn: 5989 init1: 5989 opt: 5989 Z-score: 6310.9 bits: 1178.9 E(85289): 0
Smith-Waterman score: 5989; 100.0% identity (100.0% similar) in 888 aa overlap (35-922:1-888)
10 20 30 40 50 60
pF1KA1 GHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRL
::::::::::::::::::::::::::::::
NP_001 MEGDDCEFRYGDGTNEAQDNDFPTVERSRL
10 20 30
70 80 90 100 110 120
pF1KA1 QEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA1 MVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA1 SDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFRED
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA1 SVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA1 ISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 YSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 IVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDE
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 LRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFIS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 GISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGV
520 530 540 550 560 570
610 620 630 640 650 660
pF1KA1 EHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 WVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLI
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 TVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETK
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 DIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQME
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 KQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNG
820 830 840 850 860 870
910 920
pF1KA1 LSNQNKNIQQLIELVRRL
::::::::::::::::::
NP_001 LSNQNKNIQQLIELVRRL
880
>>NP_001277004 (OMIM: 610337) up-regulator of cell proli (888 aa)
initn: 5989 init1: 5989 opt: 5989 Z-score: 6310.9 bits: 1178.9 E(85289): 0
Smith-Waterman score: 5989; 100.0% identity (100.0% similar) in 888 aa overlap (35-922:1-888)
10 20 30 40 50 60
pF1KA1 GHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRL
::::::::::::::::::::::::::::::
NP_001 MEGDDCEFRYGDGTNEAQDNDFPTVERSRL
10 20 30
70 80 90 100 110 120
pF1KA1 QEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA1 MVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA1 SDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFRED
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA1 SVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA1 ISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 YSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 IVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDE
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 LRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFIS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 GISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGV
520 530 540 550 560 570
610 620 630 640 650 660
pF1KA1 EHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 WVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLI
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 TVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETK
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 DIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQME
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 KQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNG
820 830 840 850 860 870
910 920
pF1KA1 LSNQNKNIQQLIELVRRL
::::::::::::::::::
NP_001 LSNQNKNIQQLIELVRRL
880
>>NP_001071132 (OMIM: 610337) up-regulator of cell proli (888 aa)
initn: 5989 init1: 5989 opt: 5989 Z-score: 6310.9 bits: 1178.9 E(85289): 0
Smith-Waterman score: 5989; 100.0% identity (100.0% similar) in 888 aa overlap (35-922:1-888)
10 20 30 40 50 60
pF1KA1 GHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRL
::::::::::::::::::::::::::::::
NP_001 MEGDDCEFRYGDGTNEAQDNDFPTVERSRL
10 20 30
70 80 90 100 110 120
pF1KA1 QEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTT
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA1 MVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA1 SDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFRED
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA1 SVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA1 ISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 YSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 IVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDE
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 LRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFIS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 GISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGV
520 530 540 550 560 570
610 620 630 640 650 660
pF1KA1 EHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 WVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLI
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 TVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETK
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 DIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQME
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 KQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNG
820 830 840 850 860 870
910 920
pF1KA1 LSNQNKNIQQLIELVRRL
::::::::::::::::::
NP_001 LSNQNKNIQQLIELVRRL
880
>>NP_115976 (OMIM: 609986) caspase recruitment domain-co (1037 aa)
initn: 693 init1: 298 opt: 708 Z-score: 744.4 bits: 149.2 E(85289): 1e-34
Smith-Waterman score: 784; 35.2% identity (64.1% similar) in 440 aa overlap (31-464:251-668)
10 20 30 40 50 60
pF1KA1 MASPGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVE
: :. :.. .. .. . .... ..:
NP_115 PEDAEATVEEEVYDDPEHVGYDGEEDFENSETTEFSGEEPSYEGSETSLSLEEEQEKSIE
230 240 250 260 270 280
70 80 90 100 110
pF1KA1 RSRLQEMLSLLGLETYQVQKLSLQDSL-QISFDSMKNWAPQVPKDLPWNFLRKLQALNAD
. . :: :. . .:. : : . :.:.: .:.:. : :: :::: :.:: ..
NP_115 ERKKVFKDVLLCLNMDRSRKV-LPDFVKQFSLDRGCKWTPESPGDLAWNFLMKVQARDVT
290 300 310 320 330
120 130 140 150 160 170
pF1KA1 ARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLC
::.. . :: . : .:: : . .. :. .: .::::.::
NP_115 ARDSILSHKVLDE-----------------DSKEDLLAGVENL-EIRDIQT-INPLDVLC
340 350 360 370 380
180 190 200 210 220 230
pF1KA1 ALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMG
: .: ::: ::... .: :::::::.:::.::. ..: ::. ::. .: :
NP_115 ATMLCSDSSLQRQVMSNMYQCQFALPLLLPDAENNKSILMLGAMKDIVKKQSTQFSGGPT
390 400 410 420 430 440
240 250 260 270 280 290
pF1KA1 SFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGH-RQWDCFWHRDLNLGTNAREI
: ..: . :...:::. : :::..::..:::.. . : :.:: : . :.:
NP_115 EDTEKFLTLMKMPVISFVRLGYCSFSKSRILNTLLSPAQLKLHKIFLHQDLPLLVLPRQI
450 460 470 480 490 500
300 310 320 330 340 350
pF1KA1 SDGLVEISWFFPSG--REDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNI
:::::::.: ::.. :.. .: .:::. ::::.. : : :: .: :.:::::..:: .
NP_115 SDGLVEITWCFPDSDDRKENPFFQKPVALANLRGNLESFWTQFGFLMEVSSAVFFFTDCL
510 520 530 540 550 560
360 370 380 390 400 410
pF1KA1 SKKEYKLLYSMKESTTKY-YFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDS
..::. ::. . :.. . ::.:: ..... . ....... :: . . .. :
NP_115 GEKEWDLLMFLGEAAIERCYFVLSS-QARESEEAQIFQRILN-LKPAQLLFWERGDAGDR
570 580 590 600 610
420 430 440 450 460 470
pF1KA1 DSFVKRIRAIVGNVLRAPCRR-VSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKI
. .. ..: . .:. . : : ::::::: ::.::..:::: :. :. .
NP_115 RKNMEGLQAALQEVMFSSCLRCVSVEDMAALARELGIQVDEDFENTQRIQVSSGENMAGT
620 630 640 650 660 670
480 490 500 510 520 530
pF1KA1 KDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHD
NP_115 AEGEGQQRHSQLKSSSKSQALMPIQEPGTQCELSQNLQNLYGTPVFRPVLENSWLFPTRI
680 690 700 710 720 730
>>XP_016865479 (OMIM: 609986) PREDICTED: caspase recruit (743 aa)
initn: 693 init1: 298 opt: 701 Z-score: 738.8 bits: 147.7 E(85289): 2.1e-34
Smith-Waterman score: 776; 37.8% identity (66.1% similar) in 384 aa overlap (88-464:14-374)
60 70 80 90 100 110
pF1KA1 TVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALN
:.:.: .:.:. : :: :::: :.:: .
XP_016 MDRSRKVLPDFVKQFSLDRGCKWTPESPGDLAWNFLMKVQARD
10 20 30 40
120 130 140 150 160 170
pF1KA1 ADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDL
. ::.. . :: . : .:: : . .. :. .: .::::.
XP_016 VTARDSILSHKVLDE-----------------DSKEDLLAGVENL-EIRDIQT-INPLDV
50 60 70 80
180 190 200 210 220 230
pF1KA1 LCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRG
::: .: ::: ::... .: :::::::.:::.::. ..: ::. ::. .: :
XP_016 LCATMLCSDSSLQRQVMSNMYQCQFALPLLLPDAENNKSILMLGAMKDIVKKQSTQFSGG
90 100 110 120 130 140
240 250 260 270 280 290
pF1KA1 MGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGH-RQWDCFWHRDLNLGTNAR
: ..: . :...:::. : :::..::..:::.. . : :.:: : . :
XP_016 PTEDTEKFLTLMKMPVISFVRLGYCSFSKSRILNTLLSPAQLKLHKIFLHQDLPLLVLPR
150 160 170 180 190 200
300 310 320 330 340 350
pF1KA1 EISDGLVEISWFFPSG--REDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTD
.::::::::.: ::.. :.. .: .:::. ::::.. : : :: .: :.:::::..::
XP_016 QISDGLVEITWCFPDSDDRKENPFFQKPVALANLRGNLESFWTQFGFLMEVSSAVFFFTD
210 220 230 240 250 260
360 370 380 390 400 410
pF1KA1 NISKKEYKLLYSMKESTTKY-YFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLV--KVS
...::. ::. . :.. . ::.:: ..... . ..... .:.. ...: . .
XP_016 CLGEKEWDLLMFLGEAAIERCYFVLSS-QARESEEAQIFQR---ILNLKPAQLLFWERGD
270 280 290 300 310 320
420 430 440 450 460 470
pF1KA1 STDSDSFVKRIRAIVGNVLRAPCRR-VSVEDMAHAARKLGLKVDEDCEECQKAKDRMERI
. : . .. ..: . .:. . : : ::::::: ::.::..:::: :. :. .
XP_016 AGDRRKNMEGLQAALQEVMFSSCLRCVSVEDMAALARELGIQVDEDFENTQRIQVSSGEN
330 340 350 360 370 380
480 490 500 510 520 530
pF1KA1 TRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQ
XP_016 MAGTAEGEGQQRHSQLKSSSKSQALMPIQEPGTQCELSQNLQNLYGTPVFRPVLENSWLF
390 400 410 420 430 440
>>XP_016865478 (OMIM: 609986) PREDICTED: caspase recruit (851 aa)
initn: 693 init1: 298 opt: 701 Z-score: 738.1 bits: 147.7 E(85289): 2.3e-34
Smith-Waterman score: 777; 37.5% identity (65.8% similar) in 403 aa overlap (70-464:104-482)
40 50 60 70 80 90
pF1KA1 CEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSL-QISFDSMKNWA
:: :. . .:. : : . :.:.: .:.
XP_016 HFLKCLFSTFPQSAAICGLRHERKKVFKDVLLCLNMDRSRKV-LPDFVKQFSLDRGCKWT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA1 PQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAAD
:. : :: :::: :.:: .. ::.. . :: . : .:: :
XP_016 PESPGDLAWNFLMKVQARDVTARDSILSHKVLDE-----------------DSKEDLLAG
140 150 160 170
160 170 180 190 200 210
pF1KA1 IYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTF
. .. :. .: .::::.::: .: ::: ::... .: :::::::.:::.::. .
XP_016 VENL-EIRDIQT-INPLDVLCATMLCSDSSLQRQVMSNMYQCQFALPLLLPDAENNKSIL
180 190 200 210 220 230
220 230 240 250 260 270
pF1KA1 LLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGH
.: ::. ::. .: : : ..: . :...:::. : :::..::..:::..
XP_016 MLGAMKDIVKKQSTQFSGGPTEDTEKFLTLMKMPVISFVRLGYCSFSKSRILNTLLSPAQ
240 250 260 270 280 290
280 290 300 310 320 330
pF1KA1 -RQWDCFWHRDLNLGTNAREISDGLVEISWFFPSG--REDLDIFPEPVAFLNLRGDIGSH
. : :.:: : . :.::::::::.: ::.. :.. .: .:::. ::::.. :
XP_016 LKLHKIFLHQDLPLLVLPRQISDGLVEITWCFPDSDDRKENPFFQKPVALANLRGNLESF
300 310 320 330 340 350
340 350 360 370 380 390
pF1KA1 WLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKY-YFILSPYRGKRNTNLRFLNK
: :: .: :.:::::..:: ...::. ::. . :.. . ::.:: ..... . .....
XP_016 WTQFGFLMEVSSAVFFFTDCLGEKEWDLLMFLGEAAIERCYFVLSS-QARESEEAQIFQR
360 370 380 390 400 410
400 410 420 430 440 450
pF1KA1 LIPVLKIDHSHVLV--KVSSTDSDSFVKRIRAIVGNVLRAPCRR-VSVEDMAHAARKLGL
.:.. ...: . .. : . .. ..: . .:. . : : ::::::: ::.::.
XP_016 ---ILNLKPAQLLFWERGDAGDRRKNMEGLQAALQEVMFSSCLRCVSVEDMAALARELGI
420 430 440 450 460
460 470 480 490 500 510
pF1KA1 KVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDP
.:::: :. :. .
XP_016 QVDEDFENTQRIQVSSGENMAGTAEGEGQQRHSQLKSSSKSQALMPIQEPGTQCELSQNL
470 480 490 500 510 520
922 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 21:21:26 2016 done: Wed Nov 2 21:21:27 2016
Total Scan time: 12.920 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]