Result of FASTA (omim) for
pF1KA0603
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0603, 1299 aa
1>>>pF1KA0603 1299 - 1299 aa - 1299 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6093+/-0.000373; mu= 8.6024+/- 0.023
mean_var=177.4565+/-36.205, 0's: 0 Z-trim(119.7): 209 B-trim: 1853 in 1/52
Lambda= 0.096278
statistics sampled from 33829 (34058) to 33829 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.399), width: 16
Scan time: 18.940
The best scores are: opt bits E(85289)
NP_055647 (OMIM: 612465,616087) TBC1 domain family (1298) 8634 1212.3 0
XP_006719966 (OMIM: 612465,616087) PREDICTED: TBC1 (1140) 7442 1046.7 0
XP_005266662 (OMIM: 612465,616087) PREDICTED: TBC1 (1117) 7354 1034.5 0
NP_001273587 (OMIM: 612465,616087) TBC1 domain fam (1290) 5747 811.3 0
NP_001273588 (OMIM: 612465,616087) TBC1 domain fam (1235) 4629 656.0 4.5e-187
XP_005266660 (OMIM: 612465,616087) PREDICTED: TBC1 (1273) 3935 559.6 4.8e-158
XP_016876372 (OMIM: 612465,616087) PREDICTED: TBC1 (1017) 3661 521.5 1.1e-146
XP_011533633 (OMIM: 612465,616087) PREDICTED: TBC1 (1261) 3439 490.7 2.6e-137
XP_016876371 (OMIM: 612465,616087) PREDICTED: TBC1 (1054) 3349 478.2 1.3e-133
XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain (1222) 3165 452.7 7.3e-126
XP_016876373 (OMIM: 612465,616087) PREDICTED: TBC1 ( 487) 3153 450.8 1.1e-125
XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain (1242) 3083 441.3 2e-122
XP_011511966 (OMIM: 609850) PREDICTED: TBC1 domain (1241) 3045 436.0 7.7e-121
XP_011511964 (OMIM: 609850) PREDICTED: TBC1 domain (1255) 2541 366.0 9.2e-100
XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain (1262) 2508 361.4 2.2e-98
XP_011511962 (OMIM: 609850) PREDICTED: TBC1 domain (1282) 2197 318.2 2.3e-85
XP_016863407 (OMIM: 609850) PREDICTED: TBC1 domain (1228) 2180 315.9 1.1e-84
XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain ( 546) 2167 313.9 2e-84
XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain (1039) 2169 314.3 2.8e-84
NP_055988 (OMIM: 609850) TBC1 domain family member (1168) 2169 314.3 3.1e-84
XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain (1188) 2169 314.3 3.1e-84
XP_005262706 (OMIM: 609850) PREDICTED: TBC1 domain (1146) 2153 312.1 1.4e-83
XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain (1275) 2153 312.1 1.6e-83
XP_011511961 (OMIM: 609850) PREDICTED: TBC1 domain (1295) 2153 312.1 1.6e-83
XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain (1181) 2144 310.9 3.5e-83
XP_011511967 (OMIM: 609850) PREDICTED: TBC1 domain (1201) 2144 310.9 3.5e-83
XP_011511972 (OMIM: 609850) PREDICTED: TBC1 domain ( 494) 2045 296.9 2.3e-79
NP_001240841 (OMIM: 609850) TBC1 domain family mem (1159) 1573 231.5 2.6e-59
NP_001240842 (OMIM: 609850) TBC1 domain family mem ( 265) 1118 168.0 8e-41
NP_001240843 (OMIM: 609850) TBC1 domain family mem ( 265) 1118 168.0 8e-41
XP_011511970 (OMIM: 609850) PREDICTED: TBC1 domain ( 812) 924 141.3 2.6e-32
XP_016863411 (OMIM: 609850) PREDICTED: TBC1 domain ( 939) 924 141.3 3e-32
XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 778 121.0 3.6e-26
XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 778 121.0 3.6e-26
XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 778 121.1 4.2e-26
NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 778 121.1 4.2e-26
XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 778 121.1 4.2e-26
XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 778 121.1 4.2e-26
XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 778 121.1 4.2e-26
XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 778 121.1 4.2e-26
XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 732 114.7 3.3e-24
XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 732 114.7 3.4e-24
XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 732 114.7 3.5e-24
XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 732 114.7 3.5e-24
XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 683 107.8 3e-22
NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 683 107.8 3.1e-22
XP_016857771 (OMIM: 602942) PREDICTED: ecotropic v ( 812) 623 99.5 1e-19
XP_016857761 (OMIM: 602942) PREDICTED: ecotropic v ( 897) 623 99.5 1.1e-19
XP_016857759 (OMIM: 602942) PREDICTED: ecotropic v ( 927) 623 99.5 1.1e-19
XP_016857758 (OMIM: 602942) PREDICTED: ecotropic v ( 930) 623 99.5 1.1e-19
>>NP_055647 (OMIM: 612465,616087) TBC1 domain family mem (1298 aa)
initn: 5821 init1: 5821 opt: 8634 Z-score: 6485.7 bits: 1212.3 E(85289): 0
Smith-Waterman score: 8634; 99.8% identity (99.9% similar) in 1299 aa overlap (1-1299:1-1298)
10 20 30 40 50 60
pF1KA0 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVIFLSGEDDPEKIEERKKSKELR
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_055 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SLWRKAIHQQILLLRMEKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_055 SLWRKAIHQQILLLRMEKENQKLE-ASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
850 860 870 880 890
910 920 930 940 950 960
pF1KA0 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA0 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA0 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
1200 1210 1220 1230 1240 1250
1270 1280 1290
pF1KA0 KTVEQLRKLLPADALANCDLLLRDLNCNPNNKAKIGNKP
:::::::::::::::.:::::::::::::::::::::::
NP_055 KTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
1260 1270 1280 1290
>>XP_006719966 (OMIM: 612465,616087) PREDICTED: TBC1 dom (1140 aa)
initn: 4629 init1: 4629 opt: 7442 Z-score: 5591.8 bits: 1046.7 E(85289): 0
Smith-Waterman score: 7442; 99.7% identity (99.9% similar) in 1133 aa overlap (167-1299:9-1140)
140 150 160 170 180 190
pF1KA0 TYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAF
::::::::::::::::::::::::::::::
XP_006 MEDVQTPCVPDVISSIRQLSKAAMKEDAKPSKDNEDAF
10 20 30
200 210 220 230 240 250
pF1KA0 YNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLE
40 50 60 70 80 90
260 270 280 290 300 310
pF1KA0 VVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRC
100 110 120 130 140 150
320 330 340 350 360 370
pF1KA0 SSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSV
160 170 180 190 200 210
380 390 400 410 420 430
pF1KA0 VLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQA
220 230 240 250 260 270
440 450 460 470 480 490
pF1KA0 FSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIF
280 290 300 310 320 330
500 510 520 530 540 550
pF1KA0 ERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKL
340 350 360 370 380 390
560 570 580 590 600 610
pF1KA0 DILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPA
400 410 420 430 440 450
620 630 640 650 660 670
pF1KA0 SPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQ
460 470 480 490 500 510
680 690 700 710 720 730
pF1KA0 CSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDT
520 530 540 550 560 570
740 750 760 770 780 790
pF1KA0 ASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDG
580 590 600 610 620 630
800 810 820 830 840 850
pF1KA0 LDRNELLPLSPLSPTMEEEPLVIFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRM
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_006 LDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRM
640 650 660 670 680 690
860 870 880 890 900 910
pF1KA0 EKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLL
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKENQKLE-ASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLL
700 710 720 730 740 750
920 930 940 950 960 970
pF1KA0 KEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFP
760 770 780 790 800 810
980 990 1000 1010 1020 1030
pF1KA0 THPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 THPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLM
820 830 840 850 860 870
1040 1050 1060 1070 1080 1090
pF1KA0 YDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQ
880 890 900 910 920 930
1100 1110 1120 1130 1140 1150
pF1KA0 FSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSE
940 950 960 970 980 990
1160 1170 1180 1190 1200 1210
pF1KA0 MEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMD
1000 1010 1020 1030 1040 1050
1220 1230 1240 1250 1260 1270
pF1KA0 LLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_006 LLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALV
1060 1070 1080 1090 1100 1110
1280 1290
pF1KA0 NCDLLLRDLNCNPNNKAKIGNKP
:::::::::::::::::::::::
XP_006 NCDLLLRDLNCNPNNKAKIGNKP
1120 1130 1140
>>XP_005266662 (OMIM: 612465,616087) PREDICTED: TBC1 dom (1117 aa)
initn: 4541 init1: 4541 opt: 7354 Z-score: 5525.8 bits: 1034.5 E(85289): 0
Smith-Waterman score: 7354; 99.7% identity (99.9% similar) in 1118 aa overlap (182-1299:1-1117)
160 170 180 190 200 210
pF1KA0 SQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVT
::::::::::::::::::::::::::::::
XP_005 MKEDAKPSKDNEDAFYNSQKFEVLYCGKVT
10 20 30
220 230 240 250 260 270
pF1KA0 VTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEA
40 50 60 70 80 90
280 290 300 310 320 330
pF1KA0 DGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQ
100 110 120 130 140 150
340 350 360 370 380 390
pF1KA0 KSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQG
160 170 180 190 200 210
400 410 420 430 440 450
pF1KA0 IKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIK
220 230 240 250 260 270
460 470 480 490 500 510
pF1KA0 LCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEEN
280 290 300 310 320 330
520 530 540 550 560 570
pF1KA0 ELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSL
340 350 360 370 380 390
580 590 600 610 620 630
pF1KA0 ENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDS
400 410 420 430 440 450
640 650 660 670 680 690
pF1KA0 DSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESN
460 470 480 490 500 510
700 710 720 730 740 750
pF1KA0 SSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSS
520 530 540 550 560 570
760 770 780 790 800 810
pF1KA0 TCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPT
580 590 600 610 620 630
820 830 840 850 860 870
pF1KA0 MEEEPLVIFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEGASRDEL
:::::::.::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_005 MEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLE-ASRDEL
640 650 660 670 680
880 890 900 910 920 930
pF1KA0 QSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
690 700 710 720 730 740
940 950 960 970 980 990
pF1KA0 LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS
750 760 770 780 790 800
1000 1010 1020 1030 1040 1050
pF1KA0 LFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMS
810 820 830 840 850 860
1060 1070 1080 1090 1100 1110
pF1KA0 LQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
870 880 890 900 910 920
1120 1130 1140 1150 1160 1170
pF1KA0 QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISK
930 940 950 960 970 980
1180 1190 1200 1210 1220 1230
pF1KA0 QLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQAL
990 1000 1010 1020 1030 1040
1240 1250 1260 1270 1280 1290
pF1KA0 ESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALANCDLLLRDLNCNPNN
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_005 ESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNN
1050 1060 1070 1080 1090 1100
pF1KA0 KAKIGNKP
::::::::
XP_005 KAKIGNKP
1110
>>NP_001273587 (OMIM: 612465,616087) TBC1 domain family (1290 aa)
initn: 7776 init1: 4964 opt: 5747 Z-score: 4318.6 bits: 811.3 E(85289): 0
Smith-Waterman score: 8560; 99.2% identity (99.3% similar) in 1299 aa overlap (1-1299:1-1290)
10 20 30 40 50 60
pF1KA0 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
:::::::::::: ::::::::::::::::::::::::::::::::::::::::
NP_001 SGRLSPQYENEI--------SDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
730 740 750 760 770
790 800 810 820 830 840
pF1KA0 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVIFLSGEDDPEKIEERKKSKELR
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_001 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
780 790 800 810 820 830
850 860 870 880 890 900
pF1KA0 SLWRKAIHQQILLLRMEKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_001 SLWRKAIHQQILLLRMEKENQKLE-ASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
840 850 860 870 880 890
910 920 930 940 950 960
pF1KA0 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA0 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA0 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
1200 1210 1220 1230 1240 1250
1270 1280 1290
pF1KA0 KTVEQLRKLLPADALANCDLLLRDLNCNPNNKAKIGNKP
:::::::::::::::.:::::::::::::::::::::::
NP_001 KTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
1260 1270 1280 1290
>>NP_001273588 (OMIM: 612465,616087) TBC1 domain family (1235 aa)
initn: 7437 init1: 4625 opt: 4629 Z-score: 3479.6 bits: 656.0 E(85289): 4.5e-187
Smith-Waterman score: 8101; 94.9% identity (95.1% similar) in 1299 aa overlap (1-1299:1-1235)
10 20 30 40 50 60
pF1KA0 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
::::::::::::::::::
NP_001 AQGVRSPLLRQSSSEQCS------------------------------------------
670
730 740 750 760 770 780
pF1KA0 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
:::::::::::::::::::::::::::::::::::::::
NP_001 ---------------------DGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
680 690 700 710
790 800 810 820 830 840
pF1KA0 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVIFLSGEDDPEKIEERKKSKELR
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_001 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
720 730 740 750 760 770
850 860 870 880 890 900
pF1KA0 SLWRKAIHQQILLLRMEKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
NP_001 SLWRKAIHQQILLLRMEKENQKLE-ASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
780 790 800 810 820 830
910 920 930 940 950 960
pF1KA0 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
840 850 860 870 880 890
970 980 990 1000 1010 1020
pF1KA0 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
900 910 920 930 940 950
1030 1040 1050 1060 1070 1080
pF1KA0 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
960 970 980 990 1000 1010
1090 1100 1110 1120 1130 1140
pF1KA0 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
1020 1030 1040 1050 1060 1070
1150 1160 1170 1180 1190 1200
pF1KA0 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
1080 1090 1100 1110 1120 1130
1210 1220 1230 1240 1250 1260
pF1KA0 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
1140 1150 1160 1170 1180 1190
1270 1280 1290
pF1KA0 KTVEQLRKLLPADALANCDLLLRDLNCNPNNKAKIGNKP
:::::::::::::::.:::::::::::::::::::::::
NP_001 KTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
1200 1210 1220 1230
>>XP_005266660 (OMIM: 612465,616087) PREDICTED: TBC1 dom (1273 aa)
initn: 6792 init1: 3923 opt: 3935 Z-score: 2958.4 bits: 559.6 E(85289): 4.8e-158
Smith-Waterman score: 8417; 97.8% identity (98.0% similar) in 1299 aa overlap (1-1299:1-1273)
10 20 30 40 50 60
pF1KA0 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
:::::::::::::::::::::::::::::::::::::
XP_005 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSR-----------------------
550 560 570
610 620 630 640 650 660
pF1KA0 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 --DYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA0 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA0 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA0 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVIFLSGEDDPEKIEERKKSKELR
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA0 SLWRKAIHQQILLLRMEKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_005 SLWRKAIHQQILLLRMEKENQKLE-ASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA0 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA0 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA0 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA0 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KA0 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KA0 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
1180 1190 1200 1210 1220 1230
1270 1280 1290
pF1KA0 KTVEQLRKLLPADALANCDLLLRDLNCNPNNKAKIGNKP
:::::::::::::::.:::::::::::::::::::::::
XP_005 KTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
1240 1250 1260 1270
>>XP_016876372 (OMIM: 612465,616087) PREDICTED: TBC1 dom (1017 aa)
initn: 5019 init1: 2826 opt: 3661 Z-score: 2754.2 bits: 521.5 E(85289): 1.1e-146
Smith-Waterman score: 6489; 90.8% identity (91.0% similar) in 1118 aa overlap (182-1299:1-1017)
160 170 180 190 200 210
pF1KA0 SQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVT
::::::::::::::::::::::::::::::
XP_016 MKEDAKPSKDNEDAFYNSQKFEVLYCGKVT
10 20 30
220 230 240 250 260 270
pF1KA0 VTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEA
40 50 60 70 80 90
280 290 300 310 320 330
pF1KA0 DGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQ
100 110 120 130 140 150
340 350 360 370 380 390
pF1KA0 KSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQG
160 170 180 190 200 210
400 410 420 430 440 450
pF1KA0 IKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIK
220 230 240 250 260 270
460 470 480 490 500 510
pF1KA0 LCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEEN
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQ-----------
280 290 300 310
520 530 540 550 560 570
pF1KA0 ELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSL
::::::::::::::::::::::::::::::::::
XP_016 --------------------------TISNSTIPENATSSGRFKLDILKNKAKRSLTSSL
320 330 340 350
580 590 600 610 620 630
pF1KA0 ENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDS
360 370 380 390 400 410
640 650 660 670 680 690
pF1KA0 DSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESN
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQC--------------
420 430 440 450
700 710 720 730 740 750
pF1KA0 SSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSS
:::::::::::
XP_016 -------------------------------------------------SDGEGRKRTSS
460 470
760 770 780 790 800 810
pF1KA0 TCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPT
480 490 500 510 520 530
820 830 840 850 860 870
pF1KA0 MEEEPLVIFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEGASRDEL
:::::::.::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 MEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLE-ASRDEL
540 550 560 570 580
880 890 900 910 920 930
pF1KA0 QSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
590 600 610 620 630 640
940 950 960 970 980 990
pF1KA0 LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS
650 660 670 680 690 700
1000 1010 1020 1030 1040 1050
pF1KA0 LFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMS
710 720 730 740 750 760
1060 1070 1080 1090 1100 1110
pF1KA0 LQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
770 780 790 800 810 820
1120 1130 1140 1150 1160 1170
pF1KA0 QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISK
830 840 850 860 870 880
1180 1190 1200 1210 1220 1230
pF1KA0 QLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQAL
890 900 910 920 930 940
1240 1250 1260 1270 1280 1290
pF1KA0 ESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALANCDLLLRDLNCNPNN
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_016 ESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNN
950 960 970 980 990 1000
pF1KA0 KAKIGNKP
::::::::
XP_016 KAKIGNKP
1010
>>XP_011533633 (OMIM: 612465,616087) PREDICTED: TBC1 dom (1261 aa)
initn: 6299 init1: 3439 opt: 3439 Z-score: 2586.1 bits: 490.7 E(85289): 2.6e-137
Smith-Waterman score: 8302; 96.9% identity (97.1% similar) in 1299 aa overlap (1-1299:1-1261)
10 20 30 40 50 60
pF1KA0 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
:::::::::::::::::::: :::
XP_011 QRHLSSLTDNEQADIFERVQ-------------------------------------TIS
490 500
550 560 570 580 590 600
pF1KA0 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
510 520 530 540 550 560
610 620 630 640 650 660
pF1KA0 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
570 580 590 600 610 620
670 680 690 700 710 720
pF1KA0 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
630 640 650 660 670 680
730 740 750 760 770 780
pF1KA0 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
690 700 710 720 730 740
790 800 810 820 830 840
pF1KA0 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVIFLSGEDDPEKIEERKKSKELR
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
750 760 770 780 790 800
850 860 870 880 890 900
pF1KA0 SLWRKAIHQQILLLRMEKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_011 SLWRKAIHQQILLLRMEKENQKLE-ASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLN
810 820 830 840 850 860
910 920 930 940 950 960
pF1KA0 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQL
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KA0 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLL
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KA0 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEIS
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KA0 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFEN
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KA0 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETL
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KA0 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQ
1170 1180 1190 1200 1210 1220
1270 1280 1290
pF1KA0 KTVEQLRKLLPADALANCDLLLRDLNCNPNNKAKIGNKP
:::::::::::::::.:::::::::::::::::::::::
XP_011 KTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
1230 1240 1250 1260
>>XP_016876371 (OMIM: 612465,616087) PREDICTED: TBC1 dom (1054 aa)
initn: 6157 init1: 3345 opt: 3349 Z-score: 2519.7 bits: 478.2 E(85289): 1.3e-133
Smith-Waterman score: 6821; 94.1% identity (94.3% similar) in 1118 aa overlap (182-1299:1-1054)
160 170 180 190 200 210
pF1KA0 SQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVT
::::::::::::::::::::::::::::::
XP_016 MKEDAKPSKDNEDAFYNSQKFEVLYCGKVT
10 20 30
220 230 240 250 260 270
pF1KA0 VTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEA
40 50 60 70 80 90
280 290 300 310 320 330
pF1KA0 DGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQ
100 110 120 130 140 150
340 350 360 370 380 390
pF1KA0 KSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQG
160 170 180 190 200 210
400 410 420 430 440 450
pF1KA0 IKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIK
220 230 240 250 260 270
460 470 480 490 500 510
pF1KA0 LCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEEN
280 290 300 310 320 330
520 530 540 550 560 570
pF1KA0 ELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSL
340 350 360 370 380 390
580 590 600 610 620 630
pF1KA0 ENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDS
400 410 420 430 440 450
640 650 660 670 680 690
pF1KA0 DSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESN
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQC--------------
460 470 480 490
700 710 720 730 740 750
pF1KA0 SSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSS
:::::::::::
XP_016 -------------------------------------------------SDGEGRKRTSS
500
760 770 780 790 800 810
pF1KA0 TCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPT
510 520 530 540 550 560
820 830 840 850 860 870
pF1KA0 MEEEPLVIFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEGASRDEL
:::::::.::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 MEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLE-ASRDEL
570 580 590 600 610 620
880 890 900 910 920 930
pF1KA0 QSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQF
630 640 650 660 670 680
940 950 960 970 980 990
pF1KA0 LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS
690 700 710 720 730 740
1000 1010 1020 1030 1040 1050
pF1KA0 LFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMS
750 760 770 780 790 800
1060 1070 1080 1090 1100 1110
pF1KA0 LQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFL
810 820 830 840 850 860
1120 1130 1140 1150 1160 1170
pF1KA0 QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISK
870 880 890 900 910 920
1180 1190 1200 1210 1220 1230
pF1KA0 QLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQAL
930 940 950 960 970 980
1240 1250 1260 1270 1280 1290
pF1KA0 ESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALANCDLLLRDLNCNPNN
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_016 ESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNN
990 1000 1010 1020 1030 1040
pF1KA0 KAKIGNKP
::::::::
XP_016 KAKIGNKP
1050
>>XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain fam (1222 aa)
initn: 3305 init1: 1661 opt: 3165 Z-score: 2380.7 bits: 452.7 E(85289): 7.3e-126
Smith-Waterman score: 3670; 49.4% identity (71.9% similar) in 1272 aa overlap (36-1278:21-1214)
10 20 30 40 50 60
pF1KA0 CIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRR
: : ::. . ::.:::::..::.::
XP_016 MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRL
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 SQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVF--IFEHKA
:.. :....: : .: ::: : :: . : .: .. ::: :
XP_016 SRQSTRK---EPVTKQVRLCVSPSGLRCEPEPG---------RSQQWDPLIYSSIFECKP
60 70 80 90
130 140 150 160 170 180
pF1KA0 QHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMK
:.. ..:::::: .::: ::: : . : :.::.: : ..::..:::::: .: : .
XP_016 QRVHKLIHNSHDPSYFACLIK--EDAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA0 EDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQ
:. . .. .:.: :.:::::.::.:::.::::: .:::.:.:::. ...: .
XP_016 EELHCPSEFDDTF--SKKFEVLFCGRVTVAHKKAPPALIDECIEKFN-------HVSG-S
160 170 180 190 200
250 260 270 280 290 300
pF1KA0 RGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILED
:: . :: :. : :.:...:. : : . :..
XP_016 RGSE--------------SPRPNPPHAA---------PTGSQEPVRRPMRKSFSQPGLRS
210 220 230 240
310 320 330 340 350 360
pF1KA0 SGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGR
.: ..:... .: .: :. . . :. . :::.: :.:::::: .:.
XP_016 LAF--RKELQDGGLRSSGFFSSFEE----SDIENHLISGHNIVQPTDIEENRTMLFTIGQ
250 260 270 280 290
370 380 390 400 410 420
pF1KA0 FEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASE
:. :::::::...::::::.:: :::::.:::::::::::: : ...::::::..:
XP_016 SEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNE
300 310 320 330 340 350
430 440 450 460 470 480
pF1KA0 SLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRH
.::::.:.::::::..::. :.::. .:::.::..:::::::::::. ..:: .:.:
XP_016 ALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKH
360 370 380 390 400 410
490 500 510 520 530 540
pF1KA0 LSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS---
:..::..::: :::.:::..: ..:.::::.: :: : : ::: :.:::: .: .
XP_016 LTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAA
420 430 440 450 460 470
550 560 570 580 590
pF1KA0 ---NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNS
.: .: .:: ::.::.:::::::::: :::.:.::: :. :: : . ..:
XP_016 ENIGSELPPSAT---RFRLDMLKNKAKRSLTESLESILSRG-NKARGLQEHSISVDLDSS
480 490 500 510 520 530
600 610 620 630
pF1KA0 LAS------------EKDYSP-GDSPPGTPPASPP--SSAWQTFPEEDSD-SPQ--FRRR
:.: ::. : ..: .: :.. . .::: . ::: ::::
XP_016 LSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRR
540 550 560 570 580 590
640 650 660 670 680 690
pF1KA0 AHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSL
:.:.:: : .. :. . :: . : . . ..:. .. . : :
XP_016 ANTLSHFP------IECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESK
600 610 620 630 640
700 710 720 730 740 750
pF1KA0 HTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLS
: .. . . : : : . ::.. . .......:.: . :: . .:. .
XP_016 HRPGQSSAPAPPPRL-----NPSASSPNFFKYLKHNSSGEQSGNAVPKRDFESKANHLGD
650 660 670 680 690 700
760 770 780 790 800 810
pF1KA0 VGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVI
::: : :: ::::.::::::.:.. :. . .: . .:: : ::: :. :. :.
XP_016 SGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPF--
710 720 730 740 750 760
820 830 840 850 860 870
pF1KA0 FLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEGASRDELQSRKVKLD
: :... :.::: ::.::: :::::::::::::::. ::...: ....:::
XP_016 ------GPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQ-ASENDLLNKRLKLD
770 780 790 800 810
880 890 900 910 920 930
pF1KA0 YEEVGACQKEVLITWDKKLLN-CRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRL
:::. : ::: .:.: : . :.::. ::: .:. . .:::. .:::::.::: :..:
XP_016 YEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHL
820 830 840 850 860 870
940 950 960 970 980 990
pF1KA0 RHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKA
.:..:.:::: :. :::::::::.::::::.:::::::::::::.::: :::::.:.:::
XP_016 KHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKA
880 890 900 910 920 930
1000 1010 1020 1030 1040 1050
pF1KA0 YSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQ
:::::.:::::::.:::::.::::::::.::.::::::.:.:.::::::::. :::::::
XP_016 YSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQ
940 950 960 970 980 990
1060 1070 1080 1090 1100 1110
pF1KA0 LSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIF
::::::::::::::::::.::.:::::::::::.::::: :::::::::.::::::::::
XP_016 LSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIF
1000 1010 1020 1030 1040 1050
1120 1130 1140 1150 1160 1170
pF1KA0 KVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEV
:::::::.:.. ::.. :..:.::.:.:.:::... .::: :.:::::::.:::.::::
XP_016 KVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEV
1060 1070 1080 1090 1100 1110
1180 1190 1200 1210 1220 1230
pF1KA0 EYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENL
::::::.:: .:: :.. ..:::..::.:..::.::::.::::. .::.::...:.:
XP_016 EYHVLQEELIDSS-PLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKL
1120 1130 1140 1150 1160 1170
1240 1250 1260 1270 1280 1290
pF1KA0 LTRETKMKSLIRTLEQEKMAYQKTVEQLRK--LLPADALANCDLLLRDLNCNPNNKAKIG
:. :.:.:. . ::: :. : .:::.::. :.: .:
XP_016 LSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
1180 1190 1200 1210 1220
pF1KA0 NKP
1299 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 00:50:04 2016 done: Fri Nov 4 00:50:07 2016
Total Scan time: 18.940 Total Display time: 0.540
Function used was FASTA [36.3.4 Apr, 2011]