Result of FASTA (omim) for
pF1KA0189
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0189, 1023 aa
1>>>pF1KA0189 1023 - 1023 aa - 1023 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7459+/-0.000381; mu= 7.1415+/- 0.024
mean_var=218.0300+/-44.911, 0's: 0 Z-trim(120.4): 342 B-trim: 300 in 1/54
Lambda= 0.086859
statistics sampled from 35130 (35504) to 35130 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.416), width: 16
Scan time: 15.590
The best scores are: opt bits E(85289)
XP_011529371 (OMIM: 300689) PREDICTED: stAR-relate (1023) 6975 887.7 0
NP_055540 (OMIM: 300689) stAR-related lipid transf (1023) 6975 887.7 0
NP_001135976 (OMIM: 300689) stAR-related lipid tra (1023) 6975 887.7 0
NP_001135975 (OMIM: 300689) stAR-related lipid tra (1103) 6975 887.7 0
XP_005262372 (OMIM: 300689) PREDICTED: stAR-relate (1027) 6957 885.4 0
XP_011529372 (OMIM: 300689) PREDICTED: stAR-relate (1027) 6957 885.4 0
XP_005262371 (OMIM: 300689) PREDICTED: stAR-relate (1107) 6957 885.4 0
NP_006085 (OMIM: 114500,604258) rho GTPase-activat (1091) 2333 306.0 7.4e-82
NP_001303597 (OMIM: 114500,604258) rho GTPase-acti (1125) 2333 306.0 7.6e-82
NP_872584 (OMIM: 114500,604258) rho GTPase-activat (1528) 2333 306.1 9.6e-82
XP_005273431 (OMIM: 114500,604258) PREDICTED: rho (1528) 2333 306.1 9.6e-82
XP_016868440 (OMIM: 114500,604258) PREDICTED: rho (1528) 2333 306.1 9.6e-82
NP_443083 (OMIM: 609866) stAR-related lipid transf ( 995) 2307 302.7 6.6e-81
NP_001230405 (OMIM: 609866) stAR-related lipid tra (1078) 2307 302.7 7e-81
XP_011533601 (OMIM: 609866) PREDICTED: stAR-relate (1078) 2307 302.7 7e-81
XP_016876324 (OMIM: 609866) PREDICTED: stAR-relate (1078) 2307 302.7 7e-81
XP_016876323 (OMIM: 609866) PREDICTED: stAR-relate (1098) 2307 302.7 7.1e-81
NP_821075 (OMIM: 609866) stAR-related lipid transf (1105) 2307 302.7 7.2e-81
NP_821074 (OMIM: 609866) stAR-related lipid transf (1113) 2307 302.7 7.2e-81
NP_001157743 (OMIM: 114500,604258) rho GTPase-acti (1017) 2300 301.8 1.2e-80
XP_016868441 (OMIM: 114500,604258) PREDICTED: rho (1017) 2300 301.8 1.2e-80
NP_001230403 (OMIM: 609866) stAR-related lipid tra ( 646) 964 134.2 2.2e-30
NP_001230395 (OMIM: 609866) stAR-related lipid tra ( 687) 623 91.5 1.7e-17
NP_006116 (OMIM: 300118) rho GTPase-activating pro ( 765) 291 50.0 6.1e-05
NP_038267 (OMIM: 300118) rho GTPase-activating pro ( 771) 291 50.0 6.1e-05
NP_001274171 (OMIM: 300118) rho GTPase-activating ( 794) 291 50.0 6.2e-05
NP_038286 (OMIM: 300118) rho GTPase-activating pro ( 974) 291 50.1 7.3e-05
NP_001657 (OMIM: 300023) rho GTPase-activating pro ( 946) 284 49.2 0.00013
NP_001158213 (OMIM: 300023) rho GTPase-activating ( 986) 284 49.2 0.00013
NP_004482 (OMIM: 605277) rho GTPase-activating pro (1499) 285 49.5 0.00017
XP_016882203 (OMIM: 605277) PREDICTED: rho GTPase- (1499) 285 49.5 0.00017
XP_005267270 (OMIM: 613351) PREDICTED: rho GTPase- ( 585) 275 47.9 0.0002
XP_016866983 (OMIM: 613351) PREDICTED: rho GTPase- ( 635) 275 47.9 0.00021
NP_277050 (OMIM: 613351) rho GTPase-activating pro ( 663) 275 47.9 0.00022
XP_005267269 (OMIM: 613351) PREDICTED: rho GTPase- ( 713) 275 47.9 0.00023
XP_011529582 (OMIM: 300937) PREDICTED: rho GTPase- ( 411) 267 46.7 0.0003
NP_001317580 (OMIM: 300937) rho GTPase-activating ( 411) 267 46.7 0.0003
NP_001034930 (OMIM: 616310) rho GTPase-activating ( 267) 261 45.8 0.00037
NP_001269536 (OMIM: 300937) rho GTPase-activating ( 535) 267 46.8 0.00037
NP_659404 (OMIM: 300937) rho GTPase-activating pro ( 547) 267 46.8 0.00038
NP_955389 (OMIM: 610589) rho GTPase-activating pro ( 501) 265 46.6 0.00042
NP_001123537 (OMIM: 602129,609753) unconventional (2022) 272 47.9 0.00066
NP_004136 (OMIM: 602129,609753) unconventional myo (2157) 272 47.9 0.00069
NP_055598 (OMIM: 610589) rho GTPase-activating pro (1023) 265 46.8 0.00072
NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 249 44.4 0.0012
XP_016863068 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 876) 257 45.8 0.0013
XP_016863065 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 979) 257 45.8 0.0014
XP_016863066 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 979) 257 45.8 0.0014
XP_016863067 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 979) 257 45.8 0.0014
NP_055665 (OMIM: 606525) SLIT-ROBO Rho GTPase-acti (1099) 257 45.8 0.0015
>>XP_011529371 (OMIM: 300689) PREDICTED: stAR-related li (1023 aa)
initn: 6975 init1: 6975 opt: 6975 Z-score: 4734.7 bits: 887.7 E(85289): 0
Smith-Waterman score: 6975; 99.9% identity (99.9% similar) in 1023 aa overlap (1-1023:1-1023)
10 20 30 40 50 60
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGSLAGLQASMPRERRD
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
970 980 990 1000 1010 1020
pF1KA0 TKL
:::
XP_011 TKL
>>NP_055540 (OMIM: 300689) stAR-related lipid transfer p (1023 aa)
initn: 6975 init1: 6975 opt: 6975 Z-score: 4734.7 bits: 887.7 E(85289): 0
Smith-Waterman score: 6975; 99.9% identity (99.9% similar) in 1023 aa overlap (1-1023:1-1023)
10 20 30 40 50 60
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGSLAGLQASMPRERRD
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_055 AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
970 980 990 1000 1010 1020
pF1KA0 TKL
:::
NP_055 TKL
>>NP_001135976 (OMIM: 300689) stAR-related lipid transfe (1023 aa)
initn: 6975 init1: 6975 opt: 6975 Z-score: 4734.7 bits: 887.7 E(85289): 0
Smith-Waterman score: 6975; 99.9% identity (99.9% similar) in 1023 aa overlap (1-1023:1-1023)
10 20 30 40 50 60
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGSLAGLQASMPRERRD
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_001 AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
970 980 990 1000 1010 1020
pF1KA0 TKL
:::
NP_001 TKL
>>NP_001135975 (OMIM: 300689) stAR-related lipid transfe (1103 aa)
initn: 6975 init1: 6975 opt: 6975 Z-score: 4734.2 bits: 887.7 E(85289): 0
Smith-Waterman score: 6975; 99.9% identity (99.9% similar) in 1023 aa overlap (1-1023:81-1103)
10 20 30
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCT
::::::::::::::::::::::::::::::
NP_001 EGSFPLDIGSVKKNHGFLDEDSLGALCRRLMTLNNCASMKLEVHFQSKQNEDSEEEEQCT
60 70 80 90 100 110
40 50 60 70 80 90
pF1KA0 ISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLPPEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLPPEPA
120 130 140 150 160 170
100 110 120 130 140 150
pF1KA0 DLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KA0 HSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQ
240 250 260 270 280 290
220 230 240 250 260 270
pF1KA0 WTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGS
300 310 320 330 340 350
280 290 300 310 320 330
pF1KA0 HASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMY
360 370 380 390 400 410
340 350 360 370 380 390
pF1KA0 PDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQA
420 430 440 450 460 470
400 410 420 430 440 450
pF1KA0 PAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSE
480 490 500 510 520 530
460 470 480 490 500 510
pF1KA0 LDSSGNSMNEAEAAGSLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSE
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDSSGNSMNEAEAAGPLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSE
540 550 560 570 580 590
520 530 540 550 560 570
pF1KA0 SLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVF
600 610 620 630 640 650
580 590 600 610 620 630
pF1KA0 GVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNV
660 670 680 690 700 710
640 650 660 670 680 690
pF1KA0 CYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDE
720 730 740 750 760 770
700 710 720 730 740 750
pF1KA0 NREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGR
780 790 800 810 820 830
760 770 780 790 800 810
pF1KA0 PGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQ
840 850 860 870 880 890
820 830 840 850 860 870
pF1KA0 AAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVA
900 910 920 930 940 950
880 890 900 910 920 930
pF1KA0 APPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRS
960 970 980 990 1000 1010
940 950 960 970 980 990
pF1KA0 DLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPD
1020 1030 1040 1050 1060 1070
1000 1010 1020
pF1KA0 WYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
:::::::::::::::::::::::::::::::::
NP_001 WYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
1080 1090 1100
>>XP_005262372 (OMIM: 300689) PREDICTED: stAR-related li (1027 aa)
initn: 6856 init1: 6856 opt: 6957 Z-score: 4722.5 bits: 885.4 E(85289): 0
Smith-Waterman score: 6957; 99.5% identity (99.5% similar) in 1027 aa overlap (1-1023:1-1027)
10 20 30 40 50
pF1KA0 MTLNNCASMKLEVHFQSKQ----NEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPP
::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 MTLNNCASMKLEVHFQSKQCLSQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 SPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 QDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA0 YRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA0 ESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA0 DDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA0 QAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA0 SEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGSLAGLQASMPR
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_005 SEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPR
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA0 ERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAF
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA0 MEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYL
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA0 RSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIF
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA0 TSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAG
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA0 NLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA0 FQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KA0 GWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQV
850 860 870 880 890 900
900 910 920 930 940 950
pF1KA0 LEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVR
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KA0 ALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQA
970 980 990 1000 1010 1020
1020
pF1KA0 AGPETKL
:::::::
XP_005 AGPETKL
>>XP_011529372 (OMIM: 300689) PREDICTED: stAR-related li (1027 aa)
initn: 6856 init1: 6856 opt: 6957 Z-score: 4722.5 bits: 885.4 E(85289): 0
Smith-Waterman score: 6957; 99.5% identity (99.5% similar) in 1027 aa overlap (1-1023:1-1027)
10 20 30 40 50
pF1KA0 MTLNNCASMKLEVHFQSKQ----NEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPP
::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 MTLNNCASMKLEVHFQSKQCLSQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 SPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 QDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA0 YRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA0 ESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA0 DDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KA0 QAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KA0 SEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGSLAGLQASMPR
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 SEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPR
430 440 450 460 470 480
480 490 500 510 520 530
pF1KA0 ERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAF
490 500 510 520 530 540
540 550 560 570 580 590
pF1KA0 MEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYL
550 560 570 580 590 600
600 610 620 630 640 650
pF1KA0 RSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIF
610 620 630 640 650 660
660 670 680 690 700 710
pF1KA0 TSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAG
670 680 690 700 710 720
720 730 740 750 760 770
pF1KA0 NLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KA0 FQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KA0 GWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQV
850 860 870 880 890 900
900 910 920 930 940 950
pF1KA0 LEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVR
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KA0 ALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQA
970 980 990 1000 1010 1020
1020
pF1KA0 AGPETKL
:::::::
XP_011 AGPETKL
>>XP_005262371 (OMIM: 300689) PREDICTED: stAR-related li (1107 aa)
initn: 6856 init1: 6856 opt: 6957 Z-score: 4722.0 bits: 885.4 E(85289): 0
Smith-Waterman score: 6957; 99.5% identity (99.5% similar) in 1027 aa overlap (1-1023:81-1107)
10 20
pF1KA0 MTLNNCASMKLEVHFQSKQ----NEDSEEE
::::::::::::::::::: :::::::
XP_005 EGSFPLDIGSVKKNHGFLDEDSLGALCRRLMTLNNCASMKLEVHFQSKQCLSQNEDSEEE
60 70 80 90 100 110
30 40 50 60 70 80
pF1KA0 EQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLP
120 130 140 150 160 170
90 100 110 120 130 140
pF1KA0 PEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQ
180 190 200 210 220 230
150 160 170 180 190 200
pF1KA0 AEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASF
240 250 260 270 280 290
210 220 230 240 250 260
pF1KA0 RHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCG
300 310 320 330 340 350
270 280 290 300 310 320
pF1KA0 STGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWS
360 370 380 390 400 410
330 340 350 360 370 380
pF1KA0 RAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLA
420 430 440 450 460 470
390 400 410 420 430 440
pF1KA0 PAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVA
480 490 500 510 520 530
450 460 470 480 490 500
pF1KA0 SSSELDSSGNSMNEAEAAGSLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_005 SSSELDSSGNSMNEAEAAGPLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPS
540 550 560 570 580 590
510 520 530 540 550 560
pF1KA0 LNSESLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNSESLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRG
600 610 620 630 640 650
570 580 590 600 610 620
pF1KA0 QHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETS
660 670 680 690 700 710
630 640 650 660 670 680
pF1KA0 PDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLL
720 730 740 750 760 770
690 700 710 720 730 740
pF1KA0 LPDENREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPDENREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRS
780 790 800 810 820 830
750 760 770 780 790 800
pF1KA0 LIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAEL
840 850 860 870 880 890
810 820 830 840 850 860
pF1KA0 RQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKAS
900 910 920 930 940 950
870 880 890 900 910 920
pF1KA0 TEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLR
960 970 980 990 1000 1010
930 940 950 960 970 980
pF1KA0 MWRSDLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MWRSDLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRG
1020 1030 1040 1050 1060 1070
990 1000 1010 1020
pF1KA0 RSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
:::::::::::::::::::::::::::::::::::::
XP_005 RSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
1080 1090 1100
>>NP_006085 (OMIM: 114500,604258) rho GTPase-activating (1091 aa)
initn: 2150 init1: 1061 opt: 2333 Z-score: 1590.6 bits: 306.0 E(85289): 7.4e-82
Smith-Waterman score: 2416; 41.4% identity (62.6% similar) in 1132 aa overlap (2-1022:68-1089)
10 20 30
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTI
:::.:: ::::. . :...::.:.: :.:
NP_006 FLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSDDSDEDEPCAI
40 50 60 70 80 90
40 50 60
pF1KA0 SSHWAFQQESKCWSPMGSSDLLAP-----------------PSPG-----LPATSSCESV
:..:.::..:: :: . :...: :::: : . ::
NP_006 SGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPSPGGTLMDLSERQEVSSV
100 110 120 130 140 150
70 80 90 100 110
pF1KA0 LTELSATSLPVITVSLPPEPADLP-------------LPGRAPS----SSDRPLLSPTQG
. :. ::: . . : : : : : : : : . : : . .
NP_006 RSLSSTGSLP--SHAPPSEDAATPRTNSVISVCSSSNLAGNDDSFGSLPSPKELSSFSFS
160 170 180 190 200 210
120 130 140 150 160
pF1KA0 QEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKH------SPATSEKVSKA----
..: . ::. ..::.::..:::. : . :.. :.. .: .: ...
NP_006 MKGHEKTAKS--KTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPILQEGMDEEKLKQ
220 230 240 250 260 270
170 180 190 200
pF1KA0 ------SSFRSCRGFLSAGFYRAK---NWAATSAGGSGANTRKAWEAW-PVASFRH----
:.. . : ... . : . : . ::...: ..: .: . ::. :
NP_006 LNCVEISALNGNR--INVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSAC
280 290 300 310 320 330
210 220 230 240
pF1KA0 ------------P--QWTHRG--------------DCLVHVPGDHKPGTFPRSLSIESLC
: : : . : . ..: ::::::::..:. :.
NP_006 NKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPEDHKPGTFPKALTNGSFS
340 350 360 370 380 390
250 260 270 280
pF1KA0 PEDGHRLADWQ------PG----RRWGCEG------RRGSCGSTGSHASTYDNLPELYPA
: .. ..:. :: :: . ::.: .: .:. : :::.:
NP_006 PSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVP-----
400 410 420 430 440
290 300 310 320 330 340
pF1KA0 EPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEAT
.. . . : : :. . .::::: :: :.:. :. ::. . : : .: :
NP_006 -GSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEK-FSDEGDSD----SAL
450 460 470 480 490 500
350 360 370 380 390 400
pF1KA0 SSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEA
.::
NP_006 DSV---------------------------------------------------------
410 420 430 440 450 460
pF1KA0 PAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAA
.: :. : .. : :.:.. .. . :.:::.:::.:: :
NP_006 ---SPCPS----SPKQIH----------LDVDNDRT------TPSDLDSTGNSLNEPEEP
510 520 530 540
470 480 490 500 510 520
pF1KA0 GSLAGLQASMPRERRDSGVGASLTRPCR-KLRWHSFQNSHRPSLNSESLEINRQFAGQIN
. .: ::::::::::::: : .:::::::.:::::::: ::.:: : ..:.:
NP_006 -------SEIP-ERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMN
550 560 570 580 590
530 540 550 560 570 580
pF1KA0 LLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQ
::.: :::.:::..:::: .:.:. :..::::.: :.:::. . ::::: ..::::::
NP_006 LLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQ
600 610 620 630 640 650
590 600 610 620 630 640
pF1KA0 PLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADL
::::::::::::::..::::::.::::::::::: :::::: . : : :::::::::::.
NP_006 PLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADM
660 670 680 690 700 710
650 660 670 680 690 700
pF1KA0 LKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLS
:::::::::::..:.::. ::::::: .:::: : : .:: .::::::::::::::::::
NP_006 LKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLS
720 730 740 750 760 770
710 720 730 740 750 760
pF1KA0 DIASA-EENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAA
:...: .::::: :::::::::.::::. :... :::. .... .:.: .::..:.::
NP_006 DVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAA
780 790 800 810 820 830
770 780 790 800 810 820
pF1KA0 TQGLSHMISDCKKLFQVPQDMVLQLC-SSYSAAELSP-PGPALAELRQAQAAGVSLSLYM
::::.:::..::::::::..: . : .::. ::.: ::..: . ..: . . ..
NP_006 TQGLAHMIAECKKLFQVPEEM--SRCRNSYTEQELKPLTLEALGHLGNDDSA--DYQHFL
840 850 860 870 880
830 840 850 860 870 880
pF1KA0 EENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRV
.. .. :.... :.::::.: ...::. .:. .: :::::.. :: : : .:.:.
NP_006 QDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRL
890 900 910 920 930 940
890 900 910 920 930 940
pF1KA0 LRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLV
:.:. ::: ::: ..:.: : .:.:.:: .:::::: ::.:::: ::..::.:.: :.
NP_006 LKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALL
950 960 970 980 990 1000
950 960 970 980 990 1000
pF1KA0 SQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLC
:.: .. .: :::. .: :.::.:::: :.:.::..::.::::. :.::.: :::::
NP_006 LTSVDHDR-APVVGVRVNVLLSRYLIEPCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLC
1010 1020 1030 1040 1050 1060
1010 1020
pF1KA0 AMEVAKIRDSFPTLQAAGPETKL
: ::.:::::: . .. .::
NP_006 AAEVVKIRDSFSNQNTETKDTKSR
1070 1080 1090
>>NP_001303597 (OMIM: 114500,604258) rho GTPase-activati (1125 aa)
initn: 2160 init1: 1061 opt: 2333 Z-score: 1590.4 bits: 306.0 E(85289): 7.6e-82
Smith-Waterman score: 2416; 41.4% identity (62.6% similar) in 1132 aa overlap (2-1022:102-1123)
10 20 30
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTI
:::.:: ::::. . :...::.:.: :.:
NP_001 FLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSDDSDEDEPCAI
80 90 100 110 120 130
40 50 60
pF1KA0 SSHWAFQQESKCWSPMGSSDLLAP-----------------PSPG-----LPATSSCESV
:..:.::..:: :: . :...: :::: : . ::
NP_001 SGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPSPGGTLMDLSERQEVSSV
140 150 160 170 180 190
70 80 90 100 110
pF1KA0 LTELSATSLPVITVSLPPEPADLP-------------LPGRAPS----SSDRPLLSPTQG
. :. ::: . . : : : : : : : : . : : . .
NP_001 RSLSSTGSLP--SHAPPSEDAATPRTNSVISVCSSSNLAGNDDSFGSLPSPKELSSFSFS
200 210 220 230 240
120 130 140 150 160
pF1KA0 QEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKH------SPATSEKVSKA----
..: . ::. ..::.::..:::. : . :.. :.. .: .: ...
NP_001 MKGHEKTAKS--KTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPILQEGMDEEKLKQ
250 260 270 280 290 300
170 180 190 200
pF1KA0 ------SSFRSCRGFLSAGFYRAK---NWAATSAGGSGANTRKAWEAW-PVASFRH----
:.. . : ... . : . : . ::...: ..: .: . ::. :
NP_001 LNCVEISALNGNR--INVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSAC
310 320 330 340 350 360
210 220 230 240
pF1KA0 ------------P--QWTHRG--------------DCLVHVPGDHKPGTFPRSLSIESLC
: : : . : . ..: ::::::::..:. :.
NP_001 NKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPEDHKPGTFPKALTNGSFS
370 380 390 400 410 420
250 260 270 280
pF1KA0 PEDGHRLADWQ------PG----RRWGCEG------RRGSCGSTGSHASTYDNLPELYPA
: .. ..:. :: :: . ::.: .: .:. : :::.:
NP_001 PSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVP-----
430 440 450 460 470 480
290 300 310 320 330 340
pF1KA0 EPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEAT
.. . . : : :. . .::::: :: :.:. :. ::. . : : .: :
NP_001 -GSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEK-FSDEGDSD----SAL
490 500 510 520 530
350 360 370 380 390 400
pF1KA0 SSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEA
.::
NP_001 DSV---------------------------------------------------------
410 420 430 440 450 460
pF1KA0 PAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAA
.: :. : .. : :.:.. .. . :.:::.:::.:: :
NP_001 ---SPCPS----SPKQIH----------LDVDNDRT------TPSDLDSTGNSLNEPEEP
540 550 560 570
470 480 490 500 510 520
pF1KA0 GSLAGLQASMPRERRDSGVGASLTRPCR-KLRWHSFQNSHRPSLNSESLEINRQFAGQIN
. .: ::::::::::::: : .:::::::.:::::::: ::.:: : ..:.:
NP_001 -------SEIP-ERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMN
580 590 600 610 620
530 540 550 560 570 580
pF1KA0 LLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQ
::.: :::.:::..:::: .:.:. :..::::.: :.:::. . ::::: ..::::::
NP_001 LLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQ
630 640 650 660 670 680
590 600 610 620 630 640
pF1KA0 PLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADL
::::::::::::::..::::::.::::::::::: :::::: . : : :::::::::::.
NP_001 PLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADM
690 700 710 720 730 740
650 660 670 680 690 700
pF1KA0 LKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLS
:::::::::::..:.::. ::::::: .:::: : : .:: .::::::::::::::::::
NP_001 LKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLS
750 760 770 780 790 800
710 720 730 740 750 760
pF1KA0 DIASA-EENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAA
:...: .::::: :::::::::.::::. :... :::. .... .:.: .::..:.::
NP_001 DVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAA
810 820 830 840 850 860
770 780 790 800 810 820
pF1KA0 TQGLSHMISDCKKLFQVPQDMVLQLC-SSYSAAELSP-PGPALAELRQAQAAGVSLSLYM
::::.:::..::::::::..: . : .::. ::.: ::..: . ..: . . ..
NP_001 TQGLAHMIAECKKLFQVPEEM--SRCRNSYTEQELKPLTLEALGHLGNDDSA--DYQHFL
870 880 890 900 910 920
830 840 850 860 870 880
pF1KA0 EENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRV
.. .. :.... :.::::.: ...::. .:. .: :::::.. :: : : .:.:.
NP_001 QDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRL
930 940 950 960 970 980
890 900 910 920 930 940
pF1KA0 LRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLV
:.:. ::: ::: ..:.: : .:.:.:: .:::::: ::.:::: ::..::.:.: :.
NP_001 LKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALL
990 1000 1010 1020 1030 1040
950 960 970 980 990 1000
pF1KA0 SQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLC
:.: .. .: :::. .: :.::.:::: :.:.::..::.::::. :.::.: :::::
NP_001 LTSVDHDR-APVVGVRVNVLLSRYLIEPCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLC
1050 1060 1070 1080 1090 1100
1010 1020
pF1KA0 AMEVAKIRDSFPTLQAAGPETKL
: ::.:::::: . .. .::
NP_001 AAEVVKIRDSFSNQNTETKDTKSR
1110 1120
>>NP_872584 (OMIM: 114500,604258) rho GTPase-activating (1528 aa)
initn: 2150 init1: 1061 opt: 2333 Z-score: 1588.6 bits: 306.1 E(85289): 9.6e-82
Smith-Waterman score: 2416; 41.4% identity (62.6% similar) in 1132 aa overlap (2-1022:505-1526)
10 20 30
pF1KA0 MTLNNCASMKLEVHFQSKQNEDSEEEEQCTI
:::.:: ::::. . :...::.:.: :.:
NP_872 FLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSDDSDEDEPCAI
480 490 500 510 520 530
40 50 60
pF1KA0 SSHWAFQQESKCWSPMGSSDLLAP-----------------PSPG-----LPATSSCESV
:..:.::..:: :: . :...: :::: : . ::
NP_872 SGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPSPGGTLMDLSERQEVSSV
540 550 560 570 580 590
70 80 90 100 110
pF1KA0 LTELSATSLPVITVSLPPEPADLP-------------LPGRAPS----SSDRPLLSPTQG
. :. ::: . . : : : : : : : : . : : . .
NP_872 RSLSSTGSLP--SHAPPSEDAATPRTNSVISVCSSSNLAGNDDSFGSLPSPKELSSFSFS
600 610 620 630 640 650
120 130 140 150 160
pF1KA0 QEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKH------SPATSEKVSKA----
..: . ::. ..::.::..:::. : . :.. :.. .: .: ...
NP_872 MKGHEKTAKS--KTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPILQEGMDEEKLKQ
660 670 680 690 700 710
170 180 190 200
pF1KA0 ------SSFRSCRGFLSAGFYRAK---NWAATSAGGSGANTRKAWEAW-PVASFRH----
:.. . : ... . : . : . ::...: ..: .: . ::. :
NP_872 LNCVEISALNGNR--INVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSAC
720 730 740 750 760
210 220 230 240
pF1KA0 ------------P--QWTHRG--------------DCLVHVPGDHKPGTFPRSLSIESLC
: : : . : . ..: ::::::::..:. :.
NP_872 NKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPEDHKPGTFPKALTNGSFS
770 780 790 800 810 820
250 260 270 280
pF1KA0 PEDGHRLADWQ------PG----RRWGCEG------RRGSCGSTGSHASTYDNLPELYPA
: .. ..:. :: :: . ::.: .: .:. : :::.:
NP_872 PSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVP-----
830 840 850 860 870 880
290 300 310 320 330 340
pF1KA0 EPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEAT
.. . . : : :. . .::::: :: :.:. :. ::. . : : .: :
NP_872 -GSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEK-FSDEGDSD----SAL
890 900 910 920 930
350 360 370 380 390 400
pF1KA0 SSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEA
.::
NP_872 DSV---------------------------------------------------------
940
410 420 430 440 450 460
pF1KA0 PAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAA
.: :. : .. : :.:.. .. . :.:::.:::.:: :
NP_872 ---SPCPS----SPKQIH----------LDVDNDRT------TPSDLDSTGNSLNEPEEP
950 960 970
470 480 490 500 510 520
pF1KA0 GSLAGLQASMPRERRDSGVGASLTRPCR-KLRWHSFQNSHRPSLNSESLEINRQFAGQIN
. .: ::::::::::::: : .:::::::.:::::::: ::.:: : ..:.:
NP_872 -------SEIP-ERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMN
980 990 1000 1010 1020
530 540 550 560 570 580
pF1KA0 LLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQ
::.: :::.:::..:::: .:.:. :..::::.: :.:::. . ::::: ..::::::
NP_872 LLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQ
1030 1040 1050 1060 1070 1080
590 600 610 620 630 640
pF1KA0 PLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADL
::::::::::::::..::::::.::::::::::: :::::: . : : :::::::::::.
NP_872 PLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADM
1090 1100 1110 1120 1130 1140
650 660 670 680 690 700
pF1KA0 LKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLS
:::::::::::..:.::. ::::::: .:::: : : .:: .::::::::::::::::::
NP_872 LKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLS
1150 1160 1170 1180 1190 1200
710 720 730 740 750 760
pF1KA0 DIASA-EENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAA
:...: .::::: :::::::::.::::. :... :::. .... .:.: .::..:.::
NP_872 DVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAA
1210 1220 1230 1240 1250 1260
770 780 790 800 810 820
pF1KA0 TQGLSHMISDCKKLFQVPQDMVLQLC-SSYSAAELSP-PGPALAELRQAQAAGVSLSLYM
::::.:::..::::::::..: . : .::. ::.: ::..: . ..: . . ..
NP_872 TQGLAHMIAECKKLFQVPEEM--SRCRNSYTEQELKPLTLEALGHLGNDDSA--DYQHFL
1270 1280 1290 1300 1310 1320
830 840 850 860 870 880
pF1KA0 EENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRV
.. .. :.... :.::::.: ...::. .:. .: :::::.. :: : : .:.:.
NP_872 QDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRL
1330 1340 1350 1360 1370 1380
890 900 910 920 930 940
pF1KA0 LRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLV
:.:. ::: ::: ..:.: : .:.:.:: .:::::: ::.:::: ::..::.:.: :.
NP_872 LKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALL
1390 1400 1410 1420 1430 1440
950 960 970 980 990 1000
pF1KA0 SQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLC
:.: .. .: :::. .: :.::.:::: :.:.::..::.::::. :.::.: :::::
NP_872 LTSVDHDR-APVVGVRVNVLLSRYLIEPCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLC
1450 1460 1470 1480 1490 1500
1010 1020
pF1KA0 AMEVAKIRDSFPTLQAAGPETKL
: ::.:::::: . .. .::
NP_872 AAEVVKIRDSFSNQNTETKDTKSR
1510 1520
1023 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:33:51 2016 done: Thu Nov 3 19:33:54 2016
Total Scan time: 15.590 Total Display time: 0.510
Function used was FASTA [36.3.4 Apr, 2011]