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[1][TOP]
>UniRef100_Q3EAG8 Methylenetetrahydrofolate reductase n=1 Tax=Arabidopsis thaliana
RepID=Q3EAG8_ARATH
Length = 407
Score = 291 bits (746), Expect = 1e-77
Identities = 139/139 (100%), Positives = 139/139 (100%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY
Sbjct: 226 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG
Sbjct: 286 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 345
Query: 362 WNDFPHGRWGDSHSAAYST 418
WNDFPHGRWGDSHSAAYST
Sbjct: 346 WNDFPHGRWGDSHSAAYST 364
[2][TOP]
>UniRef100_B9DHL6 Methylenetetrahydrofolate reductase (Fragment) n=1 Tax=Arabidopsis
thaliana RepID=B9DHL6_ARATH
Length = 402
Score = 291 bits (746), Expect = 1e-77
Identities = 139/139 (100%), Positives = 139/139 (100%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY
Sbjct: 36 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 95
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG
Sbjct: 96 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 155
Query: 362 WNDFPHGRWGDSHSAAYST 418
WNDFPHGRWGDSHSAAYST
Sbjct: 156 WNDFPHGRWGDSHSAAYST 174
[3][TOP]
>UniRef100_Q9SE60-2 Isoform 2 of Methylenetetrahydrofolate reductase 1 n=1
Tax=Arabidopsis thaliana RepID=Q9SE60-2
Length = 421
Score = 291 bits (746), Expect = 1e-77
Identities = 139/139 (100%), Positives = 139/139 (100%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY
Sbjct: 226 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG
Sbjct: 286 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 345
Query: 362 WNDFPHGRWGDSHSAAYST 418
WNDFPHGRWGDSHSAAYST
Sbjct: 346 WNDFPHGRWGDSHSAAYST 364
[4][TOP]
>UniRef100_Q9SE60 Methylenetetrahydrofolate reductase 1 n=1 Tax=Arabidopsis thaliana
RepID=MTHR1_ARATH
Length = 592
Score = 291 bits (746), Expect = 1e-77
Identities = 139/139 (100%), Positives = 139/139 (100%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY
Sbjct: 226 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG
Sbjct: 286 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 345
Query: 362 WNDFPHGRWGDSHSAAYST 418
WNDFPHGRWGDSHSAAYST
Sbjct: 346 WNDFPHGRWGDSHSAAYST 364
[5][TOP]
>UniRef100_O80585 Methylenetetrahydrofolate reductase 2 n=1 Tax=Arabidopsis thaliana
RepID=MTHR2_ARATH
Length = 594
Score = 255 bits (651), Expect = 1e-66
Identities = 117/137 (85%), Positives = 127/137 (92%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY+GFLRM GFCKTKIP E+ AALEPIKDN+EAVKAYGIH TEMCKK+LAHG+ SLHLY
Sbjct: 226 NYRGFLRMTGFCKTKIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+ ILMNLG+IDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG
Sbjct: 286 TLNMEKSALAILMNLGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W DFP GRWGDS SA+Y
Sbjct: 346 WEDFPQGRWGDSRSASY 362
[6][TOP]
>UniRef100_Q10BJ6 Methylenetetrahydrofolate reductase n=1 Tax=Oryza sativa Japonica
Group RepID=Q10BJ6_ORYSJ
Length = 573
Score = 246 bits (629), Expect = 4e-64
Identities = 114/137 (83%), Positives = 125/137 (91%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIPAE+TAALEPIKDN+EAVKAYGIH TEMCKKILA GI +LHLY
Sbjct: 226 NYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+GILMNLGLI+ESKISRSLPWR P NVFR KEDVRPIFWANRPKSYISRT G
Sbjct: 286 TLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDS + +Y
Sbjct: 346 WDQYPHGRWGDSRNPSY 362
[7][TOP]
>UniRef100_Q75HE6 Probable methylenetetrahydrofolate reductase n=3 Tax=Oryza sativa
RepID=MTHR_ORYSJ
Length = 594
Score = 246 bits (629), Expect = 4e-64
Identities = 114/137 (83%), Positives = 125/137 (91%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIPAE+TAALEPIKDN+EAVKAYGIH TEMCKKILA GI +LHLY
Sbjct: 226 NYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+GILMNLGLI+ESKISRSLPWR P NVFR KEDVRPIFWANRPKSYISRT G
Sbjct: 286 TLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDS + +Y
Sbjct: 346 WDQYPHGRWGDSRNPSY 362
[8][TOP]
>UniRef100_B9HG95 Methylenetetrahydrofolate reductase n=1 Tax=Populus trichocarpa
RepID=B9HG95_POPTR
Length = 608
Score = 246 bits (628), Expect = 6e-64
Identities = 111/137 (81%), Positives = 126/137 (91%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIPAE+TAALEPIKDN+EAV+AYGIH TEMCKKILAHGI +LHLY
Sbjct: 240 NYKGFLRMTGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLY 299
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+ ILMNLGLI+ESKI+R+LPWR P NVFR KEDVRPIFWANRPKSY+SRT G
Sbjct: 300 TLNMEKSALAILMNLGLIEESKITRALPWRPPTNVFRAKEDVRPIFWANRPKSYLSRTIG 359
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDSH+ +Y
Sbjct: 360 WDQYPHGRWGDSHNPSY 376
[9][TOP]
>UniRef100_B9N8L0 Methylenetetrahydrofolate reductase n=1 Tax=Populus trichocarpa
RepID=B9N8L0_POPTR
Length = 606
Score = 242 bits (617), Expect = 1e-62
Identities = 109/137 (79%), Positives = 125/137 (91%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGF+RMAGFCKTKIPAE+TAALEPIKDN+EAV+AYGIH TEMCKKILAHGI +LHLY
Sbjct: 237 NYKGFIRMAGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLY 296
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+ ILMNLGLI+ESKI+R LPWR P NVFR KEDVRPIFWANRPKSY++RT G
Sbjct: 297 TLNMEKSALAILMNLGLIEESKITRPLPWRPPTNVFRVKEDVRPIFWANRPKSYLTRTIG 356
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDS + +Y
Sbjct: 357 WDQYPHGRWGDSRNPSY 373
[10][TOP]
>UniRef100_UPI00019838C7 PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
RepID=UPI00019838C7
Length = 594
Score = 241 bits (615), Expect = 2e-62
Identities = 110/137 (80%), Positives = 123/137 (89%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIP+E+TAALEPIKDNDEAVKAYGIH TEMCKKILAHGI ++HLY
Sbjct: 226 NYKGFLRMTGFCKTKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTVHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+ ILMNLGLI+ESKISR PWRRP NVFR KEDVRPIFWANRP+SYISRT G
Sbjct: 286 TLNMEKSALAILMNLGLIEESKISRPFPWRRPTNVFRVKEDVRPIFWANRPRSYISRTIG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRW DS + +Y
Sbjct: 346 WDQYPHGRWSDSCNPSY 362
[11][TOP]
>UniRef100_A5ATB7 Methylenetetrahydrofolate reductase n=1 Tax=Vitis vinifera
RepID=A5ATB7_VITVI
Length = 594
Score = 241 bits (615), Expect = 2e-62
Identities = 110/137 (80%), Positives = 123/137 (89%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIP+E+TAALEPIKDNDEAVKAYGIH TEMCKKILAHGI ++HLY
Sbjct: 226 NYKGFLRMTGFCKTKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTVHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+ ILMNLGLI+ESKISR PWRRP NVFR KEDVRPIFWANRP+SYISRT G
Sbjct: 286 TLNMEKSALAILMNLGLIEESKISRPFPWRRPTNVFRVKEDVRPIFWANRPRSYISRTIG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRW DS + +Y
Sbjct: 346 WDQYPHGRWSDSCNPSY 362
[12][TOP]
>UniRef100_A6XMY8 Methylenetetrahydrofolate reductase n=1 Tax=Triticum monococcum
RepID=A6XMY8_TRIMO
Length = 582
Score = 239 bits (611), Expect = 5e-62
Identities = 108/137 (78%), Positives = 124/137 (90%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGF+RM GFCKTKIPAE+TAAL+PIKDN+EAVKAYGIH TEMCKKILA GI +LHLY
Sbjct: 214 NYKGFVRMTGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLY 273
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++K+A+ ILMNLGLI+ESK+SR+LPWR P NVFR KEDVRPIFWANRPKSYISRT G
Sbjct: 274 TLNMEKTALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTG 333
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDS + +Y
Sbjct: 334 WDQYPHGRWGDSRNPSY 350
[13][TOP]
>UniRef100_C5WVY7 Methylenetetrahydrofolate reductase n=1 Tax=Sorghum bicolor
RepID=C5WVY7_SORBI
Length = 593
Score = 237 bits (604), Expect = 3e-61
Identities = 108/137 (78%), Positives = 121/137 (88%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIP+E+TAAL+PIKDN+EAVK YGIH TEMCKKILA GI +LHLY
Sbjct: 226 NYKGFLRMTGFCKTKIPSEITAALDPIKDNEEAVKQYGIHLGTEMCKKILATGIKTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN+DKSAIGILMNLGLI+ESK+SR LPWR NVFR KEDVRPIFWANRPKSY+ RT G
Sbjct: 286 TLNMDKSAIGILMNLGLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANRPKSYLKRTLG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDS + +Y
Sbjct: 346 WDQYPHGRWGDSRNPSY 362
[14][TOP]
>UniRef100_B9STA4 Methylenetetrahydrofolate reductase n=1 Tax=Ricinus communis
RepID=B9STA4_RICCO
Length = 609
Score = 236 bits (603), Expect = 4e-61
Identities = 109/137 (79%), Positives = 121/137 (88%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIPAE+TAALEPIKDN+EAV+AYGIH TEMCKKI+AHGI +LHLY
Sbjct: 241 NYKGFLRMTGFCKTKIPAEVTAALEPIKDNEEAVRAYGIHLGTEMCKKIMAHGIKTLHLY 300
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+ ILMNLGLI+ESKISR LPWR P NVFR KE VRPIFWANRPKSYISRT G
Sbjct: 301 TLNMEKSALAILMNLGLIEESKISRPLPWRPPTNVFRVKEGVRPIFWANRPKSYISRTLG 360
Query: 362 WNDFPHGRWGDSHSAAY 412
W +P GRWGDS + +Y
Sbjct: 361 WEQYPQGRWGDSCNPSY 377
[15][TOP]
>UniRef100_Q9SE94 Methylenetetrahydrofolate reductase 1 n=1 Tax=Zea mays
RepID=MTHR1_MAIZE
Length = 593
Score = 236 bits (601), Expect = 8e-61
Identities = 107/137 (78%), Positives = 121/137 (88%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIP+E+TAAL+PIKDN+EAV+ YGIH TEMCKKILA GI +LHLY
Sbjct: 226 NYKGFLRMTGFCKTKIPSEITAALDPIKDNEEAVRQYGIHLGTEMCKKILATGIKTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN+DKSAIGILMNLGLI+ESK+SR LPWR NVFR KEDVRPIFWANRPKSY+ RT G
Sbjct: 286 TLNMDKSAIGILMNLGLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANRPKSYLKRTLG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRWGDS + +Y
Sbjct: 346 WDQYPHGRWGDSRNPSY 362
[16][TOP]
>UniRef100_B8LKP0 Methylenetetrahydrofolate reductase n=1 Tax=Picea sitchensis
RepID=B8LKP0_PICSI
Length = 594
Score = 233 bits (593), Expect = 6e-60
Identities = 107/137 (78%), Positives = 121/137 (88%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGF+RMAGFCKTKIP+E+TAALEPIKDN+EAV+AYGIH TEMCKKILAHGI +LHLY
Sbjct: 226 NYKGFIRMAGFCKTKIPSEITAALEPIKDNEEAVRAYGIHLGTEMCKKILAHGIKTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN++KSA+GIL NLGLID +KI R LPWR NV RTKE+VRPIFWANRP+SYISRT G
Sbjct: 286 TLNMEKSALGILANLGLIDMTKIRRPLPWRPATNVLRTKENVRPIFWANRPRSYISRTIG 345
Query: 362 WNDFPHGRWGDSHSAAY 412
W FP+GRWGD+ S AY
Sbjct: 346 WEQFPNGRWGDARSPAY 362
[17][TOP]
>UniRef100_A9U4S7 Methylenetetrahydrofolate reductase n=1 Tax=Physcomitrella patens
subsp. patens RepID=A9U4S7_PHYPA
Length = 592
Score = 223 bits (568), Expect = 5e-57
Identities = 102/139 (73%), Positives = 117/139 (84%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM CKTK+PAE+ AALEPIKDNDEAV+AYGIH TEMCKKILAH I +LHLY
Sbjct: 226 NYKGFLRMTTLCKTKVPAEIMAALEPIKDNDEAVRAYGIHLGTEMCKKILAHDIRTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
+LN++KS +GIL NLGLID S++SR LPWR P N RTKEDVRPIFWANRP+SYISRT
Sbjct: 286 SLNLEKSVLGILQNLGLIDFSRVSRPLPWRPPTNSKRTKEDVRPIFWANRPRSYISRTTS 345
Query: 362 WNDFPHGRWGDSHSAAYST 418
W+DFP GRWGD+ + AY +
Sbjct: 346 WDDFPRGRWGDTANPAYGS 364
[18][TOP]
>UniRef100_A9RW65 Methylenetetrahydrofolate reductase n=1 Tax=Physcomitrella patens
subsp. patens RepID=A9RW65_PHYPA
Length = 594
Score = 221 bits (562), Expect = 3e-56
Identities = 100/139 (71%), Positives = 116/139 (83%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM CKTK+PAE+ A LEPIKDNDEAV+AYGIH TEMCKKILAH I +LHLY
Sbjct: 226 NYKGFLRMTSLCKTKVPAEIMATLEPIKDNDEAVRAYGIHLGTEMCKKILAHDIRTLHLY 285
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
+LN++KS +GIL NLGLID SK++R LPWR P N RTKEDVRPIFWANRP+SYISRT
Sbjct: 286 SLNLEKSVLGILQNLGLIDFSKVTRPLPWRPPTNSKRTKEDVRPIFWANRPRSYISRTTS 345
Query: 362 WNDFPHGRWGDSHSAAYST 418
W++FP GRWGD+ + AY +
Sbjct: 346 WDEFPRGRWGDTGNPAYGS 364
[19][TOP]
>UniRef100_A7PSQ4 Methylenetetrahydrofolate reductase n=1 Tax=Vitis vinifera
RepID=A7PSQ4_VITVI
Length = 587
Score = 207 bits (528), Expect = 2e-52
Identities = 100/137 (72%), Positives = 112/137 (81%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGFLRM GFCKTKIP+E+TAALEPIKDNDEAVKAYGIH TEMCKKILAHGI + L
Sbjct: 226 NYKGFLRMTGFCKTKIPSEVTAALEPIKDNDEAVKAYGIHLGTEMCKKILAHGIKTFGL- 284
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
T+++ NLGLI+ESKISR PWRRP NVFR KEDVRPIFWANRP+SYISRT G
Sbjct: 285 TMDLP------WQNLGLIEESKISRPFPWRRPTNVFRVKEDVRPIFWANRPRSYISRTIG 338
Query: 362 WNDFPHGRWGDSHSAAY 412
W+ +PHGRW DS + +Y
Sbjct: 339 WDQYPHGRWSDSCNPSY 355
[20][TOP]
>UniRef100_A8IAY6 Methylenetetrahydrofolate reductase n=1 Tax=Chlamydomonas
reinhardtii RepID=A8IAY6_CHLRE
Length = 594
Score = 177 bits (450), Expect = 2e-43
Identities = 80/138 (57%), Positives = 104/138 (75%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y GF RM GFCKTK+PAE++ ALE IKDNDEAVKAYGI MC+++LA G + +H+Y
Sbjct: 221 YGGFKRMTGFCKTKVPAEISDALEAIKDNDEAVKAYGIDLGVRMCRQLLASGEVPGVHMY 280
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRR-PANVFRTKEDVRPIFWANRPKSYISRTK 358
TLN++KSA+ IL LGL+D S++ R LPWR PA R E VRP+FW+NRPK+Y+ RT+
Sbjct: 281 TLNLEKSAVAILEQLGLVDTSRVQRPLPWRHVPAGTARAVEQVRPVFWSNRPKAYVKRTQ 340
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+ +P GRWG++ S AY
Sbjct: 341 DWDSYPAGRWGNTRSPAY 358
[21][TOP]
>UniRef100_C6T731 Methylenetetrahydrofolate reductase n=1 Tax=Glycine max
RepID=C6T731_SOYBN
Length = 344
Score = 143 bits (361), Expect(2) = 2e-41
Identities = 66/82 (80%), Positives = 76/82 (92%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYKGF+RM GFCKTKIPA++ AALEPIKDN+EAVKAYGIH TEMCKKILAHGI +LHLY
Sbjct: 227 NYKGFIRMTGFCKTKIPADIMAALEPIKDNEEAVKAYGIHLGTEMCKKILAHGINTLHLY 286
Query: 182 TLNVDKSAIGILMNLGLIDESK 247
TLN++KSA+ ILMNLGLI+E+K
Sbjct: 287 TLNMEKSALAILMNLGLIEETK 308
Score = 49.7 bits (117), Expect(2) = 2e-41
Identities = 26/37 (70%), Positives = 28/37 (75%)
Frame = +3
Query: 246 KFLVLYLGDALQMFSVLRKMFAQFSGQTVQRATYLEQ 356
KFL YLGDALQMFSVL+KM Q GQ VQ+ATY Q
Sbjct: 308 KFLGPYLGDALQMFSVLKKMSVQSFGQIVQKATYQGQ 344
[22][TOP]
>UniRef100_Q54X84 Methylenetetrahydrofolate reductase n=1 Tax=Dictyostelium
discoideum RepID=Q54X84_DICDI
Length = 627
Score = 150 bits (380), Expect = 3e-35
Identities = 69/136 (50%), Positives = 91/136 (66%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y GF+RM KTK+P + LEPIKDNDE VK YG+ EM K++L G+ LH YT
Sbjct: 220 YAGFVRMTTLSKTKVPQYIMDNLEPIKDNDEEVKKYGVRLCVEMSKRLLDFGVEGLHFYT 279
Query: 185 LNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGW 364
LN+++S +L L L+ ++S LPW + A R KE+VRPIFW NRP+SYI+RT W
Sbjct: 280 LNLERSVRKVLKGLQLVTPDQLSPFLPWAQSAAGNRLKEEVRPIFWQNRPRSYIARTGSW 339
Query: 365 NDFPHGRWGDSHSAAY 412
++FP+GRWGD S A+
Sbjct: 340 DEFPNGRWGDYRSPAF 355
[23][TOP]
>UniRef100_B7G287 Methylenetetrahydrofolate reductase n=1 Tax=Phaeodactylum
tricornutum CCAP 1055/1 RepID=B7G287_PHATR
Length = 634
Score = 142 bits (359), Expect = 9e-33
Identities = 76/149 (51%), Positives = 97/149 (65%), Gaps = 12/149 (8%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSL--- 172
+Y F RM +C +P E+ LEPIKD+DEAVK G A EMC++ILA I +
Sbjct: 243 SYSSFTRMTQYCGVSVPDEIWKRLEPIKDDDEAVKEIGCSLAAEMCRQILADPIAKIDGV 302
Query: 173 HLYTLNVDKSAIGILMNL------GLIDE--SKISRSLPWRRPANVFRTK-EDVRPIFWA 325
H YTLN+++SA ILM L GL+D+ +K R LPWR A R+K E VRPI WA
Sbjct: 303 HFYTLNLERSATRILMQLDGTVNSGLVDKIRTKSGRILPWRPSAMTGRSKMEQVRPINWA 362
Query: 326 NRPKSYISRTKGWNDFPHGRWGDSHSAAY 412
NRPKSY+ RT+ W++FP+GRWGDS S A+
Sbjct: 363 NRPKSYVLRTEDWDEFPNGRWGDSTSPAF 391
[24][TOP]
>UniRef100_UPI00006A3477 PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase
(NADPH) n=1 Tax=Ciona intestinalis RepID=UPI00006A3477
Length = 644
Score = 139 bits (351), Expect = 7e-32
Identities = 67/137 (48%), Positives = 95/137 (69%), Gaps = 2/137 (1%)
Frame = +2
Query: 8 KGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLYT 184
+ +++ K IP E+ +EPIKDND A++ YGI AT+MC+ +L G + LH+YT
Sbjct: 235 RSLVQLTKLSKLSIPEEIQKVIEPIKDNDAAIRKYGIDLATDMCRTLLNSGKVHGLHMYT 294
Query: 185 LNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTK-EDVRPIFWANRPKSYISRTKG 361
LN++ + I IL NLGL + +++ LPW+ AN R + E VRPIFW +RPKSYI RT+G
Sbjct: 295 LNLETATIQILKNLGLWCQD-VAKPLPWKTSANPERRENETVRPIFWCDRPKSYIHRTQG 353
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 354 WDEFPNGRWGDSASPAF 370
[25][TOP]
>UniRef100_UPI0001555C53 PREDICTED: similar to methylenetetrahydrofolate reductase n=1
Tax=Ornithorhynchus anatinus RepID=UPI0001555C53
Length = 646
Score = 139 bits (350), Expect = 1e-31
Identities = 66/137 (48%), Positives = 92/137 (67%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y ++ K ++P E+TA +EPIKDND A++ YGI A MC+++L G+ S LH Y
Sbjct: 259 YHSLRQLVKLSKLEVPQEITAVIEPIKDNDAAIRNYGIELAVTMCRELLVSGVVSGLHFY 318
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ +E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 319 TLNREVATVEVLKRLGIWNEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIYRTQD 377
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 378 WDEFPNGRWGNSSSPAF 394
[26][TOP]
>UniRef100_UPI00016DFE38 UPI00016DFE38 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016DFE38
Length = 514
Score = 138 bits (348), Expect = 2e-31
Identities = 68/137 (49%), Positives = 91/137 (66%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y+ ++ K ++P E+T+ LEPIKDND A++ YGI A EMC+ +L G + LH Y
Sbjct: 266 YQSLRQLVKLSKLEVPEEITSILEPIKDNDAAIRNYGIQLAVEMCRVLLDSGKVPGLHFY 325
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LGL E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 326 TLNREVATMEVLRQLGLWTEDP-RRPLPWAVSAHPKRKVEDVRPIFWASRPKSYIYRTQD 384
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 385 WDDFPNGRWGNSSSPAF 401
[27][TOP]
>UniRef100_B0V153 Methylenetetrahydrofolate reductase n=1 Tax=Danio rerio
RepID=B0V153_DANRE
Length = 656
Score = 137 bits (344), Expect = 5e-31
Identities = 68/137 (49%), Positives = 90/137 (65%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A EMCK +LA G ++ LH Y
Sbjct: 262 YHSLRQLVKLSKLEVPEEIKQVIEPIKDNDAAIRNYGIQQAVEMCKVLLASGEVSGLHFY 321
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LGL E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 322 TLNREVATMEVLRQLGLWAEDP-RRPLPWAISAHPKRKVEDVRPIFWASRPKSYIYRTQD 380
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 381 WDDFPNGRWGNSSSPAF 397
[28][TOP]
>UniRef100_C3XPI2 Methylenetetrahydrofolate reductase n=2 Tax=Branchiostoma floridae
RepID=C3XPI2_BRAFL
Length = 686
Score = 136 bits (343), Expect = 6e-31
Identities = 65/137 (47%), Positives = 91/137 (66%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y + K +IP E+ A+EPI+DNDEA++ YG+H A M +++ G+ + LH Y
Sbjct: 251 YHSLRNLVKLSKLEIPDEIREAIEPIRDNDEAIRNYGVHQAVTMIRELFDSGLVNGLHFY 310
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + I IL +GL E I R PW+R AN R +E+VRPIFWA+RPKSY+ RT+
Sbjct: 311 TLNREVATIQILKQIGLWTED-IQRPWPWKRTANYNRCEEEVRPIFWASRPKSYVYRTQE 369
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG S S A+
Sbjct: 370 WDEFPNGRWGSSESPAF 386
[29][TOP]
>UniRef100_A1C6H3 Methylenetetrahydrofolate reductase n=1 Tax=Aspergillus clavatus
RepID=A1C6H3_ASPCL
Length = 619
Score = 136 bits (343), Expect = 6e-31
Identities = 66/138 (47%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + K +IP E ALEP+K++D AVK G EMC+K+LA G+ LH YT
Sbjct: 218 YAAFIRRANWTKARIPPEWLEALEPVKNDDAAVKEIGKRLIAEMCRKLLAAGLNHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI +E+ + R LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQATQSVLDELKLIPSEETPLQRPLPWRPSLGLNRRGEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 IWDEFPNGRWTDSRSPAF 355
[30][TOP]
>UniRef100_B3S098 Methylenetetrahydrofolate reductase n=1 Tax=Trichoplax adhaerens
RepID=B3S098_TRIAD
Length = 633
Score = 136 bits (342), Expect = 8e-31
Identities = 63/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y + K +P + +E IKDNDEA++ +GI AT +CKK+LA + +H+Y
Sbjct: 245 YNSLRHLVQLSKLPVPQRILDTIESIKDNDEAIRKFGIVEATNLCKKLLASDDVPGIHVY 304
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN +++ + +L +GL E I +SLPWR AN R EDVRPIFWA+RPKSY+ RT
Sbjct: 305 TLNREEAVVKLLKRVGLWHEESIYKSLPWRPSANGKRISEDVRPIFWASRPKSYVHRTMM 364
Query: 362 WNDFPHGRWGDSHSAAY 412
W+++P+GRWG S S A+
Sbjct: 365 WDEYPNGRWGSSASPAF 381
[31][TOP]
>UniRef100_C4Y415 Methylenetetrahydrofolate reductase n=1 Tax=Clavispora lusitaniae
ATCC 42720 RepID=C4Y415_CLAL4
Length = 614
Score = 136 bits (342), Expect = 8e-31
Identities = 63/141 (44%), Positives = 90/141 (63%), Gaps = 5/141 (3%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + IP AL PIK++D A++ G +EMC+K++ G + LH Y
Sbjct: 221 YSAFIRRANWSQVAIPQHFLDALNPIKEDDYAIREVGTQLVSEMCQKLIDSGYVNHLHFY 280
Query: 182 TLNVDKSAIGILMNLGLIDESK----ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYIS 349
T+N+++S + IL L L++ K + LPWR+ N R+KE +RPIFW NR SYIS
Sbjct: 281 TMNLERSTVMILEKLNLVESIKDNDAVVEILPWRKSLNPSRSKESIRPIFWQNRKYSYIS 340
Query: 350 RTKGWNDFPHGRWGDSHSAAY 412
RT GW++FP+GRWGDS S A+
Sbjct: 341 RTSGWDEFPNGRWGDSRSPAF 361
[32][TOP]
>UniRef100_UPI0000F2D0FD PREDICTED: similar to methylenetetrahydrofolate reductase n=1
Tax=Monodelphis domestica RepID=UPI0000F2D0FD
Length = 642
Score = 135 bits (339), Expect = 2e-30
Identities = 65/137 (47%), Positives = 90/137 (65%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A MCK++LA G+ LH Y
Sbjct: 256 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVTMCKELLASGLVPGLHFY 315
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ +E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 316 TLNREVATMEVLKRLGMWNEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIYRTQA 374
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 375 WDEFPNGRWGNSSSPAF 391
[33][TOP]
>UniRef100_Q4X140 Methylenetetrahydrofolate reductase n=1 Tax=Aspergillus fumigatus
RepID=Q4X140_ASPFU
Length = 615
Score = 134 bits (338), Expect = 2e-30
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + K +IP + ALEP+K++D AVK G +MC+++LA GI LH YT
Sbjct: 218 YAAFIRRANWTKARIPPDWLEALEPVKNDDAAVKEIGKRLVADMCRRLLAAGINHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI +E+ + R LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQATQAVLEELKLIPSEETPLQRPLPWRPSLALNRRGEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[34][TOP]
>UniRef100_B0XSG0 Methylenetetrahydrofolate reductase n=1 Tax=Aspergillus fumigatus
A1163 RepID=B0XSG0_ASPFC
Length = 615
Score = 134 bits (338), Expect = 2e-30
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + K +IP + ALEP+K++D AVK G +MC+++LA GI LH YT
Sbjct: 218 YAAFIRRANWTKARIPPDWLEALEPVKNDDAAVKEIGKRLVADMCRRLLAAGINHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI +E+ + R LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQATQAVLEELKLIPSEETPLQRPLPWRPSLALNRRGEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[35][TOP]
>UniRef100_UPI00017B529C UPI00017B529C related cluster n=1 Tax=Tetraodon nigroviridis
RepID=UPI00017B529C
Length = 660
Score = 134 bits (337), Expect = 3e-30
Identities = 65/137 (47%), Positives = 91/137 (66%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y+ ++ K ++P E+T+ +EPIKDND A++ YGI A +MC+ +L G + LH Y
Sbjct: 266 YQSLRQLVKLSKLELPEEITSIIEPIKDNDAAIRNYGIQLAVQMCRVLLDSGKVPGLHFY 325
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LGL E R LPW A+ R EDVRPIFW++RPKSYI RT+
Sbjct: 326 TLNREVATMEVLRQLGLWIEDP-RRPLPWAVSAHPKRKVEDVRPIFWSSRPKSYIYRTQD 384
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 385 WDDFPNGRWGNSSSPAF 401
[36][TOP]
>UniRef100_Q4T956 Methylenetetrahydrofolate reductase n=1 Tax=Tetraodon nigroviridis
RepID=Q4T956_TETNG
Length = 845
Score = 134 bits (337), Expect = 3e-30
Identities = 65/137 (47%), Positives = 91/137 (66%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y+ ++ K ++P E+T+ +EPIKDND A++ YGI A +MC+ +L G + LH Y
Sbjct: 266 YQSLRQLVKLSKLELPEEITSIIEPIKDNDAAIRNYGIQLAVQMCRVLLDSGKVPGLHFY 325
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LGL E R LPW A+ R EDVRPIFW++RPKSYI RT+
Sbjct: 326 TLNREVATMEVLRQLGLWIEDP-RRPLPWAVSAHPKRKVEDVRPIFWSSRPKSYIYRTQD 384
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 385 WDDFPNGRWGNSSSPAF 401
[37][TOP]
>UniRef100_A1DH45 Methylenetetrahydrofolate reductase n=1 Tax=Neosartorya fischeri
NRRL 181 RepID=A1DH45_NEOFI
Length = 615
Score = 134 bits (337), Expect = 3e-30
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + K +IP + ALEP+K++D AVK G +MC+++LA GI LH YT
Sbjct: 218 YAAFIRRANWTKARIPPDWLEALEPVKNDDAAVKEIGKRLVADMCRRLLAAGIKHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI +E+ + R LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQATQAVLEELKLIPSEETPLQRPLPWRPSLALNRRGEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[38][TOP]
>UniRef100_C5JE18 Methylenetetrahydrofolate reductase n=1 Tax=Ajellomyces
dermatitidis SLH14081 RepID=C5JE18_AJEDS
Length = 633
Score = 134 bits (336), Expect = 4e-30
Identities = 63/138 (45%), Positives = 92/138 (66%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP + ALEP+K++D AV+ G +MCKKILA GI LH YT
Sbjct: 218 YAAFIRRSNWTKIRIPPDWLEALEPVKNDDAAVRNLGKSLVADMCKKILASGIYHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ IL LGLI K + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLQQATKMILDELGLIPSHKTPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[39][TOP]
>UniRef100_C5GPB7 Methylenetetrahydrofolate reductase n=1 Tax=Ajellomyces
dermatitidis ER-3 RepID=C5GPB7_AJEDR
Length = 633
Score = 134 bits (336), Expect = 4e-30
Identities = 63/138 (45%), Positives = 92/138 (66%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP + ALEP+K++D AV+ G +MCKKILA GI LH YT
Sbjct: 218 YAAFIRRSNWTKIRIPPDWLEALEPVKNDDAAVRNLGKSLVADMCKKILASGIYHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ IL LGLI K + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLQQATKMILDELGLIPSHKTPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[40][TOP]
>UniRef100_C7Z4M2 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
RepID=C7Z4M2_NECH7
Length = 618
Score = 133 bits (334), Expect = 7e-30
Identities = 64/138 (46%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR A K KIP ALEP+K++D AV+ G EMC+K+LA+GI LH YT
Sbjct: 218 YASFLRRANHMKAKIPQAWLDALEPVKNDDVAVRDIGKSLVAEMCRKLLANGIHHLHFYT 277
Query: 185 LNVDKSAIGIL--MNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L +N E + +LPW++ + R +EDVRPIFW NR KSY+ RT+
Sbjct: 278 MNLAQATRMVLEELNWAPSAERPLQHALPWKQSKGLGRREEDVRPIFWRNRNKSYVIRTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[41][TOP]
>UniRef100_A2QCE3 Methylenetetrahydrofolate reductase n=1 Tax=Aspergillus niger CBS
513.88 RepID=A2QCE3_ASPNC
Length = 626
Score = 133 bits (334), Expect = 7e-30
Identities = 62/138 (44%), Positives = 92/138 (66%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + KT+IP + ALEP+K++D AV+ G +MC++++A GI LH YT
Sbjct: 218 YAAFIRRSDWTKTRIPPDWLEALEPVKNDDAAVRDIGKRLIADMCRRLIAAGINHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ +S +L L L+ +E+ + R+LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQSTQLVLDELNLMPSEETPLQRALPWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[42][TOP]
>UniRef100_C5FFF6 Methylenetetrahydrofolate reductase n=1 Tax=Microsporum canis CBS
113480 RepID=C5FFF6_NANOT
Length = 623
Score = 132 bits (333), Expect = 9e-30
Identities = 62/138 (44%), Positives = 91/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + K KIP ALEP+K++D AVK G +EMC+K+L +GI LH YT
Sbjct: 218 YAAFIRRTNWVKCKIPKGWMEALEPVKNDDAAVKQIGRALVSEMCRKLLDNGINHLHFYT 277
Query: 185 LNVDKSAIGIL--MNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ +S +L +NL E+ + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLAQSTTMVLEELNLKPSTETPLQKPLPWRKSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 SWDEFPNGRWTDSRSPAF 355
[43][TOP]
>UniRef100_UPI0000E1E642 PREDICTED: 5,10-methylenetetrahydrofolate reductase (NADPH) isoform
3 n=2 Tax=Pan troglodytes RepID=UPI0000E1E642
Length = 679
Score = 132 bits (332), Expect = 1e-29
Identities = 63/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 285 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFY 344
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 345 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 403
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 404 WDEFPNGRWGNSSSPAF 420
[44][TOP]
>UniRef100_UPI0000E1E641 PREDICTED: 5,10-methylenetetrahydrofolate reductase (NADPH) isoform
4 n=1 Tax=Pan troglodytes RepID=UPI0000E1E641
Length = 697
Score = 132 bits (332), Expect = 1e-29
Identities = 63/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 303 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFY 362
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 363 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 421
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 422 WDEFPNGRWGNSSSPAF 438
[45][TOP]
>UniRef100_P42898 Methylenetetrahydrofolate reductase n=2 Tax=Homo sapiens
RepID=MTHR_HUMAN
Length = 656
Score = 132 bits (332), Expect = 1e-29
Identities = 63/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 262 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFY 321
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 322 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 380
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 381 WDEFPNGRWGNSSSPAF 397
[46][TOP]
>UniRef100_Q59GJ6 Methylenetetrahydrofolate reductase (Fragment) n=1 Tax=Homo sapiens
RepID=Q59GJ6_HUMAN
Length = 672
Score = 132 bits (332), Expect = 1e-29
Identities = 63/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 292 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFY 351
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 352 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 410
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 411 WDEFPNGRWGNSSSPAF 427
[47][TOP]
>UniRef100_Q0CXY7 Methylenetetrahydrofolate reductase n=1 Tax=Aspergillus terreus
NIH2624 RepID=Q0CXY7_ASPTN
Length = 619
Score = 132 bits (332), Expect = 1e-29
Identities = 64/138 (46%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + K +IP E ALEP+K++D AVK G +MC+++LA GI LH YT
Sbjct: 218 YAAFMRRANWTKIRIPPEWLEALEPVKNDDAAVKEIGKGLIADMCRRLLAAGINHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ +S +L L L +E+ + + LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQSTQLVLEELNLTPSEETPLQKPLPWRPSLGLNRRGEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[48][TOP]
>UniRef100_UPI000194DA90 PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase
(NADPH) n=1 Tax=Taeniopygia guttata RepID=UPI000194DA90
Length = 651
Score = 132 bits (331), Expect = 2e-29
Identities = 64/137 (46%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YG+ A MC+++L G+ LH Y
Sbjct: 264 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGVELAVSMCRELLDSGMVHGLHFY 323
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LGL +E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 324 TLNREVATTEVLKRLGLWNEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIYRTQE 382
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 383 WDDFPNGRWGNSSSPAF 399
[49][TOP]
>UniRef100_C5M851 Methylenetetrahydrofolate reductase n=1 Tax=Candida tropicalis
MYA-3404 RepID=C5M851_CANTT
Length = 609
Score = 132 bits (331), Expect = 2e-29
Identities = 65/142 (45%), Positives = 89/142 (62%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y FLR A + + IP AL+PIKD+D V+ G +EMC+K+L G I LH Y
Sbjct: 218 YSAFLRRAKWSEIAIPQHFLDALDPIKDDDYLVREKGTELVSEMCQKLLESGYINHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLIDESKISR-----SLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L LI+ K + LPWR+ N R+KE +RPIFW NR SY+
Sbjct: 278 TMNLEKATVMILEKLNLIEAVKSNEIVGVTELPWRKSLNPERSKESIRPIFWQNRKYSYV 337
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
+RT W++FP+GRWGDS S A+
Sbjct: 338 TRTATWDEFPNGRWGDSRSPAF 359
[50][TOP]
>UniRef100_A4RJT6 Methylenetetrahydrofolate reductase n=1 Tax=Magnaporthe grisea
RepID=A4RJT6_MAGGR
Length = 626
Score = 132 bits (331), Expect = 2e-29
Identities = 64/138 (46%), Positives = 87/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR A + +IP E LEPIK +D AV+ G E+C+KILA GI LH YT
Sbjct: 213 YASFLRRANHMQARIPEEWLQRLEPIKTDDAAVRIVGRQLVVELCRKILAAGIHHLHFYT 272
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ +S IL +L + + +LPW++ + R +EDVRPIFW NR KSY+ RT+
Sbjct: 273 MNLAQSTALILEDLDWLPSPNKPLKHALPWKQSLGLGRREEDVRPIFWRNRNKSYVMRTQ 332
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 333 DWDEFPNGRWGDSRSPAF 350
[51][TOP]
>UniRef100_UPI0000E814FF PREDICTED: similar to Mthfr-prov protein n=1 Tax=Gallus gallus
RepID=UPI0000E814FF
Length = 508
Score = 131 bits (330), Expect = 2e-29
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YG+ A MC+++L G+ LH Y
Sbjct: 120 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGVELAVSMCRELLDSGLVHGLHFY 179
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ +E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 180 TLNREVATTEVLKRLGIWNEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIYRTQE 238
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 239 WDDFPNGRWGNSSSPAF 255
[52][TOP]
>UniRef100_UPI0000D99720 PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase
isoform 2 n=2 Tax=Macaca mulatta RepID=UPI0000D99720
Length = 679
Score = 131 bits (330), Expect = 2e-29
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C ++LA G+ LH Y
Sbjct: 285 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLHFY 344
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 345 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 403
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 404 WDEFPNGRWGNSSSPAF 420
[53][TOP]
>UniRef100_UPI0000D9971F PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase
isoform 3 n=1 Tax=Macaca mulatta RepID=UPI0000D9971F
Length = 697
Score = 131 bits (330), Expect = 2e-29
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C ++LA G+ LH Y
Sbjct: 303 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLHFY 362
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 363 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 421
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 422 WDEFPNGRWGNSSSPAF 438
[54][TOP]
>UniRef100_UPI00003BE4A8 hypothetical protein DEHA0G01551g n=1 Tax=Debaryomyces hansenii
CBS767 RepID=UPI00003BE4A8
Length = 617
Score = 131 bits (330), Expect = 2e-29
Identities = 65/142 (45%), Positives = 89/142 (62%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + IP ALEPIK++D V+A G +EMC K++ G + LH Y
Sbjct: 218 YAAFIRRAKWSEVVIPQHFLDALEPIKEDDYLVRAKGTELVSEMCTKLIKSGYVNHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLIDESKISR-----SLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++++ I IL NL LI+ K LPWR+ + R+KE +RPIFW NR SYI
Sbjct: 278 TMNLERATIMILENLNLIESVKSHEVIGGSDLPWRKSLHPQRSKESIRPIFWQNRKYSYI 337
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
SRT W++FP+GRWGDS S A+
Sbjct: 338 SRTSTWDEFPNGRWGDSRSPAF 359
[55][TOP]
>UniRef100_UPI00006A0177 Methylenetetrahydrofolate reductase (EC 1.5.1.20). n=1 Tax=Xenopus
(Silurana) tropicalis RepID=UPI00006A0177
Length = 641
Score = 131 bits (330), Expect = 2e-29
Identities = 64/137 (46%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A MC+++L G+ LH Y
Sbjct: 256 YGSLRQLVKLSKLEVPQEIMDVIEPIKDNDAAIRNYGIDLAVSMCRELLDSGLVHGLHFY 315
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + I +L LG+ E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 316 TLNREVATIDVLKRLGMWKEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIHRTQE 374
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 375 WDEFPNGRWGNSSSPAF 391
[56][TOP]
>UniRef100_UPI0000ECA34F Methylenetetrahydrofolate reductase (EC 1.5.1.20). n=1 Tax=Gallus
gallus RepID=UPI0000ECA34F
Length = 640
Score = 131 bits (330), Expect = 2e-29
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YG+ A MC+++L G+ LH Y
Sbjct: 252 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGVELAVSMCRELLDSGLVHGLHFY 311
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ +E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 312 TLNREVATTEVLKRLGIWNEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIYRTQE 370
Query: 362 WNDFPHGRWGDSHSAAY 412
W+DFP+GRWG+S S A+
Sbjct: 371 WDDFPNGRWGNSSSPAF 387
[57][TOP]
>UniRef100_Q7ZWU2 Methylenetetrahydrofolate reductase n=1 Tax=Xenopus laevis
RepID=Q7ZWU2_XENLA
Length = 643
Score = 131 bits (330), Expect = 2e-29
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A MC+++L G+ LH Y
Sbjct: 256 YGSLRQLVKLSKLEVPQEIMDVIEPIKDNDAAIRNYGIDLAVSMCRELLDSGLVHGLHFY 315
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + I +L LG+ E R +PW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 316 TLNREVATIDVLKRLGMWKEDP-RRPMPWAMSAHPKRRVEDVRPIFWASRPKSYIHRTQE 374
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 375 WDEFPNGRWGNSSSPAF 391
[58][TOP]
>UniRef100_A4IIX8 Methylenetetrahydrofolate reductase n=1 Tax=Xenopus (Silurana)
tropicalis RepID=A4IIX8_XENTR
Length = 643
Score = 131 bits (330), Expect = 2e-29
Identities = 64/137 (46%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A MC+++L G+ LH Y
Sbjct: 256 YGSLRQLVKLSKLEVPQEIMDVIEPIKDNDAAIRNYGIDLAVSMCRELLDSGLVHGLHFY 315
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + I +L LG+ E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 316 TLNREVATIDVLKRLGMWKEDP-RRPLPWAVSAHPKRRVEDVRPIFWASRPKSYIHRTQE 374
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 375 WDEFPNGRWGNSSSPAF 391
[59][TOP]
>UniRef100_C8UZX0 Methylenetetrahydrofolate reductase (EC 1.5.1.20)
[Source:UniProtKB/TrEMBL;Acc:Q5B0P7] n=2 Tax=Emericella
nidulans RepID=C8UZX0_EMENI
Length = 627
Score = 131 bits (330), Expect = 2e-29
Identities = 65/138 (47%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + KT IP + ALEP+K++D AVK G +MC++++A GI LH YT
Sbjct: 218 YAAFIRRANWTKTHIPPDWLEALEPVKNDDAAVKQVGKRLIADMCRRLIASGIKHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ +S +L L L E+ I R LPWR + R +EDVRPIFW NR SYI+RT
Sbjct: 278 MNLAQSTQLVLEELELTPTAEAPIPRPLPWRPSLGLNRREEDVRPIFWRNRNSSYIARTA 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 IWDEFPNGRWTDSRSPAF 355
[60][TOP]
>UniRef100_C4JG55 Methylenetetrahydrofolate reductase n=1 Tax=Uncinocarpus reesii
1704 RepID=C4JG55_UNCRE
Length = 625
Score = 131 bits (330), Expect = 2e-29
Identities = 63/138 (45%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR + + K ++P ALEP K++D AVK G +EMC+KIL GI LH YT
Sbjct: 218 YAAFLRRSNWVKCRVPPSWMEALEPCKNDDAAVKQIGKKLVSEMCRKILDSGIRHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ +S +L L LI E+ + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLAQSTKMVLEELDLIPSSETPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[61][TOP]
>UniRef100_B5RV11 Methylenetetrahydrofolate reductase n=1 Tax=Debaryomyces hansenii
RepID=B5RV11_DEBHA
Length = 617
Score = 131 bits (330), Expect = 2e-29
Identities = 65/142 (45%), Positives = 89/142 (62%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + IP ALEPIK++D V+A G +EMC K++ G + LH Y
Sbjct: 218 YAAFIRRAKWSEVVIPQHFLDALEPIKEDDYLVRAKGTELVSEMCTKLIKSGYVNHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLIDESKISR-----SLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++++ I IL NL LI+ K LPWR+ + R+KE +RPIFW NR SYI
Sbjct: 278 TMNLERATIMILENLNLIESVKSHEVIGGSDLPWRKSLHPQRSKESIRPIFWQNRKYSYI 337
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
SRT W++FP+GRWGDS S A+
Sbjct: 338 SRTSTWDEFPNGRWGDSRSPAF 359
[62][TOP]
>UniRef100_UPI0000DA28B6 PREDICTED: similar to Methylenetetrahydrofolate reductase n=1
Tax=Rattus norvegicus RepID=UPI0000DA28B6
Length = 660
Score = 131 bits (329), Expect = 3e-29
Identities = 62/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P + +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 267 YTSLRQLVKLSKLEVPQTIKDVIEPIKDNDAAIRNYGIELAVNLCRELLDSGLVPGLHFY 326
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+G
Sbjct: 327 TLNREVATMEVLKQLGMWTEDP-RRPLPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQG 385
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 386 WDEFPNGRWGNSSSPAF 402
[63][TOP]
>UniRef100_UPI0000DBFF71 Methylenetetrahydrofolate reductase n=1 Tax=Rattus norvegicus
RepID=UPI0000DBFF71
Length = 695
Score = 131 bits (329), Expect = 3e-29
Identities = 62/137 (45%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P + +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 302 YTSLRQLVKLSKLEVPQTIKDVIEPIKDNDAAIRNYGIELAVNLCRELLDSGLVPGLHFY 361
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+G
Sbjct: 362 TLNREVATMEVLKQLGMWTEDP-RRPLPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQG 420
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 421 WDEFPNGRWGNSSSPAF 437
[64][TOP]
>UniRef100_Q75EA7 Methylenetetrahydrofolate reductase n=1 Tax=Eremothecium gossypii
RepID=Q75EA7_ASHGO
Length = 603
Score = 130 bits (328), Expect = 3e-29
Identities = 66/148 (44%), Positives = 94/148 (63%), Gaps = 11/148 (7%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHL 178
+Y LR A +C+ ++P E LEP+KD+D+AV+ G +MC+KILA G +T LHL
Sbjct: 220 SYAALLRRAKWCQVRLPPEFLERLEPVKDDDQAVREIGTVLVADMCRKILASGHVTHLHL 279
Query: 179 YTLNVDKSAIGILMNLGLID--------ESKISRSLPWRRPANVFRTKEDVRPIFWANRP 334
YT+N++++++ IL L LID + +L WR+ N R KE VRPIFW RP
Sbjct: 280 YTMNLERASLMILERLQLIDTGGAGVRRRPSTNETLTWRKSLNPTRRKEGVRPIFWQRRP 339
Query: 335 KSYISRTKGW--NDFPHGRWGDSHSAAY 412
SY++RT W ++FP+GR+GDS S AY
Sbjct: 340 YSYVARTSQWSADEFPNGRFGDSSSPAY 367
[65][TOP]
>UniRef100_UPI00019265CF PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase n=1
Tax=Hydra magnipapillata RepID=UPI00019265CF
Length = 623
Score = 130 bits (327), Expect = 5e-29
Identities = 58/138 (42%), Positives = 92/138 (66%), Gaps = 1/138 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y L++ K ++P + LEPIK++DEA++ YG+ A MC+++L+ + +H+Y
Sbjct: 239 YASLLQLVKLSKLEVPQYIIDDLEPIKNDDEAIREYGVKLAVSMCRELLSSDDVPGIHVY 298
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LGL + R LPW+ AN+ R +EDVRPIFW++RPKSYI RT
Sbjct: 299 TLNREVATTELLQQLGLWRPYQSHRLLPWKPSANLKRLQEDVRPIFWSSRPKSYIHRTSN 358
Query: 362 WNDFPHGRWGDSHSAAYS 415
W++FP+GRWG+S + +++
Sbjct: 359 WDEFPNGRWGNSSAPSFA 376
[66][TOP]
>UniRef100_UPI0000614ECA Methylenetetrahydrofolate reductase (EC 1.5.1.20). n=2 Tax=Bos
taurus RepID=UPI0000614ECA
Length = 655
Score = 130 bits (327), Expect = 5e-29
Identities = 64/137 (46%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 261 YHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFY 320
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + I +L LGL E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 321 TLNREVATIEVLKRLGLWIEDP-RRPLPWALSAHPKRRVEDVRPIFWASRPKSYIYRTQE 379
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 380 WDEFPNGRWGNSSSPAF 396
[67][TOP]
>UniRef100_C5L500 Methylenetetrahydrofolate reductase n=1 Tax=Perkinsus marinus ATCC
50983 RepID=C5L500_9ALVE
Length = 631
Score = 130 bits (327), Expect = 5e-29
Identities = 61/143 (42%), Positives = 87/143 (60%), Gaps = 6/143 (4%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT----- 166
+Y GF +M FCKTK+P + LE +K +D+ VK G+ MC +I+++G+
Sbjct: 191 SYSGFKKMTEFCKTKVPRAIADQLEQVKGDDQRVKDLGVEICVAMCSQIMSYGVDHTHSS 250
Query: 167 -SLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSY 343
LH YTLN++ S I+ L ++D +R LPWR R +E+VRPIFW NR KS+
Sbjct: 251 GGLHFYTLNLESSVCRIIERLMMVDNHVATRVLPWRPSKASSRQEENVRPIFWRNRQKSF 310
Query: 344 ISRTKGWNDFPHGRWGDSHSAAY 412
I RT W++FP+GR G+ SAAY
Sbjct: 311 IQRTSSWDEFPNGRLGNQASAAY 333
[68][TOP]
>UniRef100_C5K575 Methylenetetrahydrofolate reductase n=1 Tax=Perkinsus marinus ATCC
50983 RepID=C5K575_9ALVE
Length = 583
Score = 130 bits (327), Expect = 5e-29
Identities = 61/143 (42%), Positives = 87/143 (60%), Gaps = 6/143 (4%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT----- 166
+Y GF +M FCKTK+P + LE +K +D+ VK G+ MC +I+++G+
Sbjct: 191 SYSGFKKMTEFCKTKVPRAIADQLEQVKGDDQRVKDLGVEICVAMCSQIMSYGVDHTHSS 250
Query: 167 -SLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSY 343
LH YTLN++ S I+ L ++D +R LPWR R +E+VRPIFW NR KS+
Sbjct: 251 GGLHFYTLNLESSVCRIIERLMMVDNHVATRVLPWRPSKASSRQEENVRPIFWRNRQKSF 310
Query: 344 ISRTKGWNDFPHGRWGDSHSAAY 412
I RT W++FP+GR G+ SAAY
Sbjct: 311 IQRTSSWDEFPNGRLGNQASAAY 333
[69][TOP]
>UniRef100_B2B2M5 Methylenetetrahydrofolate reductase n=1 Tax=Podospora anserina
RepID=B2B2M5_PODAN
Length = 610
Score = 130 bits (327), Expect = 5e-29
Identities = 63/138 (45%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR A KIP E LEP+K++D AV+ G E+C+KILA GI LH YT
Sbjct: 218 YASFLRRANHMNCKIPDEWMQRLEPVKNDDVAVRDIGKTLVAELCRKILAAGIHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L + + + ++LPW+R + R EDVRPIFW NR KSY++RT+
Sbjct: 278 MNLAQATRMVLEELDWMPSPDRPVKQALPWKRSLGLGRQVEDVRPIFWRNRNKSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[70][TOP]
>UniRef100_Q60HE5 Methylenetetrahydrofolate reductase n=1 Tax=Macaca fascicularis
RepID=MTHR_MACFA
Length = 656
Score = 130 bits (327), Expect = 5e-29
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C ++LA G+ LH Y
Sbjct: 262 YHSLRQLVKQSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLHFY 321
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 322 TLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQE 380
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 381 WDEFPNGRWGNSSSPAF 397
[71][TOP]
>UniRef100_Q5I598 Methylenetetrahydrofolate reductase n=1 Tax=Bos taurus
RepID=MTHR_BOVIN
Length = 655
Score = 130 bits (327), Expect = 5e-29
Identities = 64/137 (46%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 261 YHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFY 320
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + I +L LGL E R LPW A+ R EDVRPIFWA+RPKSYI RT+
Sbjct: 321 TLNREVATIEVLKRLGLWIEDP-RRPLPWALSAHPKRRVEDVRPIFWASRPKSYIYRTQE 379
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 380 WDEFPNGRWGNSSSPAF 396
[72][TOP]
>UniRef100_C1GYS1 Methylenetetrahydrofolate reductase n=1 Tax=Paracoccidioides
brasiliensis Pb01 RepID=C1GYS1_PARBA
Length = 629
Score = 130 bits (326), Expect = 6e-29
Identities = 61/138 (44%), Positives = 91/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP ALEP+K++D AV+ G MCKK+LA GI LH YT
Sbjct: 218 YAAFIRRSNWTKIQIPPGWLEALEPVKNDDAAVRNLGKSLVANMCKKMLASGIHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L LGLI E+ + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLQQATKMVLDELGLIPSHETPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[73][TOP]
>UniRef100_C1G7L7 Methylenetetrahydrofolate reductase n=1 Tax=Paracoccidioides
brasiliensis Pb18 RepID=C1G7L7_PARBD
Length = 629
Score = 130 bits (326), Expect = 6e-29
Identities = 61/138 (44%), Positives = 91/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP ALEP+K++D AV+ G MCKK+LA GI LH YT
Sbjct: 218 YAAFIRRSNWTKIQIPPGWLEALEPVKNDDAAVRNLGKSLVANMCKKMLASGIHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L LGLI E+ + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLQQATKMVLDELGLIPSHETPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[74][TOP]
>UniRef100_C0RZ73 Methylenetetrahydrofolate reductase n=1 Tax=Paracoccidioides
brasiliensis Pb03 RepID=C0RZ73_PARBP
Length = 629
Score = 130 bits (326), Expect = 6e-29
Identities = 61/138 (44%), Positives = 91/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP ALEP+K++D AV+ G MCKK+LA GI LH YT
Sbjct: 218 YAAFIRRSNWTKIQIPPGWLEALEPVKNDDAAVRNLGKSLVANMCKKMLASGIHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L LGLI E+ + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLQQATKMVLDELGLIPSHETPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[75][TOP]
>UniRef100_A8N945 Methylenetetrahydrofolate reductase n=1 Tax=Coprinopsis cinerea
okayama7#130 RepID=A8N945_COPC7
Length = 574
Score = 130 bits (326), Expect = 6e-29
Identities = 62/138 (44%), Positives = 85/138 (61%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG--ITSLHL 178
+ GF++ TKIP ALEP+K +DE V+ G +MC+KIL G I LH
Sbjct: 179 WNGFIKATNLASTKIPQFFLDALEPVKSDDEKVREVGTKLVADMCRKILDSGLGIRGLHF 238
Query: 179 YTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
YT+N++K +L L L+ + + LPWR+ R E +RPIFWANR KSYISRT+
Sbjct: 239 YTMNLEKGTRMLLEELNLVPRIETIKPLPWRQCLTPNRRNETIRPIFWANRTKSYISRTE 298
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GR+GDS S AY
Sbjct: 299 NWDEYPNGRFGDSRSPAY 316
[76][TOP]
>UniRef100_Q3UDB2 Methylenetetrahydrofolate reductase n=1 Tax=Mus musculus
RepID=Q3UDB2_MOUSE
Length = 695
Score = 129 bits (325), Expect = 8e-29
Identities = 61/137 (44%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 302 YTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVSLCRELLDSGLVPGLHFY 361
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 362 TLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQD 420
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 421 WDEFPNGRWGNSSSPAF 437
[77][TOP]
>UniRef100_B2KFL4 Methylenetetrahydrofolate reductase n=2 Tax=Mus musculus
RepID=B2KFL4_MOUSE
Length = 695
Score = 129 bits (325), Expect = 8e-29
Identities = 61/137 (44%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 302 YTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVSLCRELLDSGLVPGLHFY 361
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 362 TLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQD 420
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 421 WDEFPNGRWGNSSSPAF 437
[78][TOP]
>UniRef100_A2A7F7 Methylenetetrahydrofolate reductase n=2 Tax=Mus musculus
RepID=A2A7F7_MOUSE
Length = 695
Score = 129 bits (325), Expect = 8e-29
Identities = 61/137 (44%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 302 YTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVSLCRELLDSGLVPGLHFY 361
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 362 TLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQD 420
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 421 WDEFPNGRWGNSSSPAF 437
[79][TOP]
>UniRef100_Q7S830 Methylenetetrahydrofolate reductase n=1 Tax=Neurospora crassa
RepID=Q7S830_NEUCR
Length = 613
Score = 129 bits (325), Expect = 8e-29
Identities = 63/138 (45%), Positives = 86/138 (62%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A KIP E A LEP+K++D AV+ G EMC+KI+ GI LH YT
Sbjct: 218 YASFIRRANHMNCKIPEEWMAKLEPVKNDDVAVREIGKTLVAEMCRKIVDAGIRHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L + + R+LPW++ R EDVRPIFW NR KSYI+RT+
Sbjct: 278 MNLAQATRMVLEELDWLPSPNRPLKRALPWKQSLGSGRRDEDVRPIFWRNRNKSYITRTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[80][TOP]
>UniRef100_B0CU22 Methylenetetrahydrofolate reductase n=1 Tax=Laccaria bicolor
S238N-H82 RepID=B0CU22_LACBS
Length = 602
Score = 129 bits (325), Expect = 8e-29
Identities = 61/138 (44%), Positives = 85/138 (61%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAH--GITSLHL 178
+ GF R K +P ALEPIK++DE V+ G +MC++IL GI LH
Sbjct: 219 WNGFQRATSLAKIVVPQSFLDALEPIKNDDEKVREVGTRLVADMCRRILKEDIGIRGLHF 278
Query: 179 YTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
YT+N++K +L L L+ + + LPWR+ R +E +RPIFWANR KSYISRT+
Sbjct: 279 YTMNLEKGTKMLLEELNLVPRIETIKPLPWRQSLTPNRRQESIRPIFWANRTKSYISRTE 338
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GR+GDS S AY
Sbjct: 339 NWDEYPNGRFGDSRSPAY 356
[81][TOP]
>UniRef100_A5DXM5 Methylenetetrahydrofolate reductase n=1 Tax=Lodderomyces
elongisporus RepID=A5DXM5_LODEL
Length = 618
Score = 129 bits (325), Expect = 8e-29
Identities = 62/142 (43%), Positives = 89/142 (62%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + KIP ALEPIKD+D V+ G +EMC++++ G + LH Y
Sbjct: 219 YAAFIRRAKWSEIKIPPHFLEALEPIKDDDFLVREKGTELVSEMCQQLIESGYVNHLHFY 278
Query: 182 TLNVDKSAIGILMNLGLIDESKI-----SRSLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L L++ K LPWR+ + R+KE +RPIFW NR SY+
Sbjct: 279 TMNLEKATVMILEKLNLVEAIKSHDLVGGTELPWRKSLHPERSKESIRPIFWQNRKYSYV 338
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
SRT W++FP+GRWGDS S A+
Sbjct: 339 SRTATWDEFPNGRWGDSRSPAF 360
[82][TOP]
>UniRef100_Q9WU20 Methylenetetrahydrofolate reductase n=1 Tax=Mus musculus
RepID=MTHR_MOUSE
Length = 654
Score = 129 bits (325), Expect = 8e-29
Identities = 61/137 (44%), Positives = 89/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 261 YTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVRLCRELLDSGLVPGLHFY 320
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 321 TLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQD 379
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 380 WDEFPNGRWGNSSSPAF 396
[83][TOP]
>UniRef100_Q6CG63 Methylenetetrahydrofolate reductase n=1 Tax=Yarrowia lipolytica
RepID=Q6CG63_YARLI
Length = 583
Score = 129 bits (324), Expect = 1e-28
Identities = 59/137 (43%), Positives = 86/137 (62%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A +C+ +IP + LEP+KD+D V+ G +MC+K+L G I LH Y
Sbjct: 219 YASFMRRANWCQIQIPQDFLDQLEPVKDDDMRVRELGTQLVADMCQKMLDSGKIKHLHFY 278
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
T+N++K+ + +L L L + LPWR + R E VRPIFW NR +SY++RT+
Sbjct: 279 TMNLEKATVMVLERLNLPAQDSAVAPLPWRPSLALGRQDETVRPIFWKNRKQSYVARTQD 338
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 339 WDEFPNGRWGDSRSPAF 355
[84][TOP]
>UniRef100_B8NG74 Methylenetetrahydrofolate reductase n=2 Tax=Aspergillus
RepID=B8NG74_ASPFN
Length = 612
Score = 129 bits (324), Expect = 1e-28
Identities = 63/138 (45%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R A + K IP + LEP+K++D AVK G +MC+++LA GI LH YT
Sbjct: 218 YAAFIRRANWTKIHIPEDWLETLEPVKNDDAAVKEIGKVLIADMCRRLLAAGINHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L L+ +E+ I R LPWR + R EDVRPIFW NR SYI+RT+
Sbjct: 278 MNLAQATQLVLDELKLLPSEETPIQRPLPWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[85][TOP]
>UniRef100_UPI000155DDC5 PREDICTED: similar to methylenetetrahydrofolate reductase n=1
Tax=Equus caballus RepID=UPI000155DDC5
Length = 655
Score = 129 bits (323), Expect = 1e-28
Identities = 63/137 (45%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YGI A +C+++LA G+ LH Y
Sbjct: 261 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDGAIRNYGIDQAVSLCQQLLASGLVPGLHFY 320
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA RPKSYI RT+
Sbjct: 321 TLNREVATTEVLKRLGMWVEDP-RRPLPWALSAHPKRREEDVRPIFWATRPKSYIYRTQE 379
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 380 WDEFPNGRWGNSSSPAF 396
[86][TOP]
>UniRef100_UPI000023D9F4 hypothetical protein FG09572.1 n=1 Tax=Gibberella zeae PH-1
RepID=UPI000023D9F4
Length = 621
Score = 129 bits (323), Expect = 1e-28
Identities = 62/138 (44%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR A + KIP E ALEP+K++D AV+ G MC+K+LA+GI LH YT
Sbjct: 218 YASFLRRANHMQAKIPQEWLDALEPVKNDDVAVRNIGKTLVANMCRKLLANGIHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L + + +LPW++ + R +EDVRPIFW NR KSY+ RT+
Sbjct: 278 MNLAQATRMLLEELQWAPSADRPLQHALPWKQSKGLGRREEDVRPIFWRNRNKSYVIRTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[87][TOP]
>UniRef100_A8PV87 Methylenetetrahydrofolate reductase n=1 Tax=Brugia malayi
RepID=A8PV87_BRUMA
Length = 656
Score = 129 bits (323), Expect = 1e-28
Identities = 65/141 (46%), Positives = 98/141 (69%), Gaps = 3/141 (2%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHL 178
+Y+ R+A + IP + +LEPIK++D+AV+ +GI A +C+ +L++G TS+HL
Sbjct: 272 SYESIRRVAELSQLVIPDSILTSLEPIKNDDDAVRNFGIWHAVTLCRTLLSNGSATSIHL 331
Query: 179 YTLNVDKSAIGILMNLGLIDESKISRSLPWRR--PANVFRTKEDVRPIFWANRPKSYISR 352
+TLN + S+ IL LGL S + R+LPWR ++ R KEDVRPIFW+ RPKSY+ R
Sbjct: 332 FTLNREASSREILQQLGLWPRSPM-RALPWRLFGESHPVRCKEDVRPIFWSMRPKSYVFR 390
Query: 353 TKGWNDFPHGRWGDSHSAAYS 415
T+ W++FP+GRWG+S S A++
Sbjct: 391 TREWDEFPNGRWGNSSSPAFN 411
[88][TOP]
>UniRef100_Q1DNB1 Methylenetetrahydrofolate reductase n=1 Tax=Coccidioides immitis
RepID=Q1DNB1_COCIM
Length = 629
Score = 129 bits (323), Expect = 1e-28
Identities = 62/138 (44%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR + + K K+P ALEP+K++D AVK G MC+KIL GI LH YT
Sbjct: 218 YASFLRRSNWVKCKVPESWMEALEPVKNDDAAVKQIGKKLVANMCQKILDSGIRHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI E+ + + LPWR+ + R EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLAQATKMVLEELKLIPSYETPLQKPLPWRQSLGLGRRDEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[89][TOP]
>UniRef100_C5PJM0 Methylenetetrahydrofolate reductase n=1 Tax=Coccidioides posadasii
C735 delta SOWgp RepID=C5PJM0_COCP7
Length = 629
Score = 129 bits (323), Expect = 1e-28
Identities = 62/138 (44%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR + + K K+P ALEP+K++D AVK G MC+KIL GI LH YT
Sbjct: 218 YASFLRRSNWVKCKVPESWMEALEPVKNDDAAVKQIGKKLVANMCQKILDSGIRHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI E+ + + LPWR+ + R EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLAQATKMVLEELKLIPSYETPLQKPLPWRQSLGLGRRDEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRW DS S A+
Sbjct: 338 TWDEFPNGRWTDSRSPAF 355
[90][TOP]
>UniRef100_B6H6J4 Methylenetetrahydrofolate reductase n=1 Tax=Penicillium chrysogenum
Wisconsin 54-1255 RepID=B6H6J4_PENCW
Length = 610
Score = 129 bits (323), Expect = 1e-28
Identities = 59/138 (42%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K K+P+E ALEP+K++D AV+ G MC++++A GI LH YT
Sbjct: 218 YASFIRRSNWTKVKVPSEWMEALEPVKNDDSAVRDIGKTLIANMCRQLIAAGIKHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L L ++S I R LPWR + R EDVRP+FW NR SY++RT+
Sbjct: 278 MNLAQATQLVLKELELTPSEDSPIQRPLPWRPSLGLGRRSEDVRPVFWRNRNSSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[91][TOP]
>UniRef100_B2WMV1 Methylenetetrahydrofolate reductase n=1 Tax=Pyrenophora
tritici-repentis Pt-1C-BFP RepID=B2WMV1_PYRTR
Length = 646
Score = 129 bits (323), Expect = 1e-28
Identities = 60/138 (43%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
+ FLR A + + IP T ALEP+K++D V+ G +MC+K++A GIT LH YT
Sbjct: 218 HAAFLRRAQWTRCNIPQHWTDALEPVKNDDVEVREVGKMLVADMCRKLIAAGITHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L L+ E+ + + LPWR + R E+VRPIFW NR +SY++RT+
Sbjct: 278 MNLAQATRMVLEELDLLPDVEAPLEKPLPWRPSLGLNRRDENVRPIFWRNRNRSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[92][TOP]
>UniRef100_A6SLU6 Methylenetetrahydrofolate reductase n=1 Tax=Botryotinia fuckeliana
B05.10 RepID=A6SLU6_BOTFB
Length = 390
Score = 129 bits (323), Expect = 1e-28
Identities = 60/138 (43%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR KIP + +AALE +K++D AV+ G EMC++I+ G+ LH YT
Sbjct: 218 YASFLRRCNHMGCKIPPKWSAALEEVKNDDAAVRNIGKDLVAEMCRRIIEAGVHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L L ++ + +LPWR+ + R +EDVRPIFW NR KSY++RT+
Sbjct: 278 MNLAQATRMVLEELSLTPSNQRPLKHALPWRQSLGLGRREEDVRPIFWKNRNKSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[93][TOP]
>UniRef100_C6H337 Methylenetetrahydrofolate reductase n=1 Tax=Ajellomyces capsulatus
H143 RepID=C6H337_AJECH
Length = 524
Score = 128 bits (321), Expect = 2e-28
Identities = 60/138 (43%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP + ALEP+K++D AV+ G MC+KILA GI LH YT
Sbjct: 109 YAAFIRRSNWTKIRIPPDWLEALEPVKNDDAAVRNLGKSLVANMCRKILAAGIYHLHFYT 168
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI K + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 169 MNLQQATKMVLGELELIPSHKTPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 228
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 229 TWDEYPNGRWTDSRSPAF 246
[94][TOP]
>UniRef100_C0NNE8 Methylenetetrahydrofolate reductase n=1 Tax=Ajellomyces capsulatus
G186AR RepID=C0NNE8_AJECG
Length = 633
Score = 128 bits (321), Expect = 2e-28
Identities = 60/138 (43%), Positives = 90/138 (65%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y F+R + + K +IP + ALEP+K++D AV+ G MC+KILA GI LH YT
Sbjct: 218 YAAFIRRSNWTKIRIPPDWLEALEPVKNDDAAVRNLGKSLVANMCRKILAAGIYHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L LI K + + LPWR+ + R +EDVRPIFW +R +SY++RT+
Sbjct: 278 MNLQQATKMVLGELELIPSHKTPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+++P+GRW DS S A+
Sbjct: 338 TWDEYPNGRWTDSRSPAF 355
[95][TOP]
>UniRef100_A7EWQ5 Methylenetetrahydrofolate reductase n=1 Tax=Sclerotinia
sclerotiorum 1980 UF-70 RepID=A7EWQ5_SCLS1
Length = 590
Score = 128 bits (321), Expect = 2e-28
Identities = 59/138 (42%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR KIP + +A+LE +K++D AV+ G EMC++I+ G+ LH YT
Sbjct: 218 YASFLRRCNHMGCKIPPKWSASLEAVKNDDSAVRNIGKDLVAEMCRRIIQAGVHHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L L ++ + +LPWR+ + R +EDVRPIFW NR KSY++RT+
Sbjct: 278 MNLAQATRMVLEELNLTPSTQRPLKHALPWRQSLGLGRREEDVRPIFWKNRNKSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[96][TOP]
>UniRef100_UPI00005A03BF PREDICTED: similar to Methylenetetrahydrofolate reductase n=1
Tax=Canis lupus familiaris RepID=UPI00005A03BF
Length = 780
Score = 127 bits (319), Expect = 4e-28
Identities = 61/137 (44%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 387 YHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLTSGLVPGLHFY 446
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 447 TLNREMATTEVLKRLGMWIEDP-RRPLPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQE 505
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 506 WDEFPNGRWGNSSSPAF 522
[97][TOP]
>UniRef100_UPI0000EB3A6F Methylenetetrahydrofolate reductase (EC 1.5.1.20). n=1 Tax=Canis
lupus familiaris RepID=UPI0000EB3A6F
Length = 696
Score = 127 bits (319), Expect = 4e-28
Identities = 61/137 (44%), Positives = 88/137 (64%), Gaps = 1/137 (0%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y ++ K ++P ++ +EPIKDND A++ YGI A +C+++L G+ LH Y
Sbjct: 303 YHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLTSGLVPGLHFY 362
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKG 361
TLN + + +L LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+
Sbjct: 363 TLNREMATTEVLKRLGMWIEDP-RRPLPWAVSAHPKRREEDVRPIFWASRPKSYIYRTQE 421
Query: 362 WNDFPHGRWGDSHSAAY 412
W++FP+GRWG+S S A+
Sbjct: 422 WDEFPNGRWGNSSSPAF 438
[98][TOP]
>UniRef100_Q5AEI0 Methylenetetrahydrofolate reductase n=1 Tax=Candida albicans
RepID=Q5AEI0_CANAL
Length = 614
Score = 126 bits (317), Expect = 7e-28
Identities = 63/142 (44%), Positives = 87/142 (61%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + IP AL+PIKD+D V+ G +EMC K+L G + LH Y
Sbjct: 218 YAAFIRRAKWSEIAIPQHFLDALDPIKDDDFLVRERGTELVSEMCNKLLQSGYVNHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLIDESKI-----SRSLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L LI+ K LPWR+ + R+KE +RPIFW +R SYI
Sbjct: 278 TMNLEKATVMILEKLNLIEAIKSHDVVGGSELPWRKSLHPERSKESIRPIFWQHRKYSYI 337
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
SRT W++FP+GRWGDS S A+
Sbjct: 338 SRTATWDEFPNGRWGDSRSPAF 359
[99][TOP]
>UniRef100_Q2H0T7 Methylenetetrahydrofolate reductase n=1 Tax=Chaetomium globosum
RepID=Q2H0T7_CHAGB
Length = 616
Score = 126 bits (317), Expect = 7e-28
Identities = 60/138 (43%), Positives = 87/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y FLR A K+P E A LE +K++D AV+ G +MC+KIL+ GI LH YT
Sbjct: 218 YASFLRRANHMNCKVPEEWMAKLESVKNDDVAVRDIGKTLVADMCRKILSAGIRHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L + + + ++LPW++ R EDVRPIFW NR KSY++RT+
Sbjct: 278 MNLAQATRMVLEELDWLPSPDRPLKQALPWKQSLGFGRRDEDVRPIFWRNRNKSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[100][TOP]
>UniRef100_C5E2N6 Methylenetetrahydrofolate reductase n=1 Tax=Lachancea
thermotolerans CBS 6340 RepID=C5E2N6_LACTC
Length = 599
Score = 126 bits (317), Expect = 7e-28
Identities = 62/144 (43%), Positives = 93/144 (64%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y FLR + +C+ +P A L+P+KD+D+AV+ G +MC+K+L G +T LH+Y
Sbjct: 221 YAAFLRRSSWCQINVPEAFMAKLDPVKDDDQAVREVGTELVAQMCQKLLDSGYVTHLHMY 280
Query: 182 TLNVDKSAIGILMNLGLIDESK-ISRS----LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ I +L LGL+ E + I R +PWR+ + R E VRPIFW RP SY+
Sbjct: 281 TMNLEKACIMVLDRLGLLSEDEDIFRDEVVPMPWRKSLHPQRRNESVRPIFWQKRPYSYV 340
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 341 ARTSQWTADEFPNGRFGDSSSPAF 364
[101][TOP]
>UniRef100_Q0U6C4 Methylenetetrahydrofolate reductase n=1 Tax=Phaeosphaeria nodorum
RepID=Q0U6C4_PHANO
Length = 657
Score = 126 bits (316), Expect = 9e-28
Identities = 59/138 (42%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
+ FLR A + + IP T ALEPIK++D V+ G +MC++++ GIT LH YT
Sbjct: 218 HASFLRRAQWTRCNIPQHWTDALEPIKNDDVEVREVGKGLVADMCRRLIEAGITHLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDE--SKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
+N+ ++ +L L L+ + S + + LPWR + R E+VRPIFW NR +SY++RT+
Sbjct: 278 MNLAQATRMVLEELDLLPDPGSPLEKPLPWRPSLGLNRRDENVRPIFWRNRNRSYVARTQ 337
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGDS S A+
Sbjct: 338 DWDEFPNGRWGDSRSPAF 355
[102][TOP]
>UniRef100_B9WDQ7 Methylenetetrahydrofolate reductase n=1 Tax=Candida dubliniensis
CD36 RepID=B9WDQ7_CANDC
Length = 614
Score = 126 bits (316), Expect = 9e-28
Identities = 63/142 (44%), Positives = 87/142 (61%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + IP AL+PIKD+D V+ G +EMC K+L G + LH Y
Sbjct: 218 YAAFIRRAKWSEIVIPQHFLDALDPIKDDDFLVRERGTELVSEMCNKLLQSGYVNHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLIDESKI-----SRSLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L LI+ K LPWR+ + R+KE +RPIFW +R SYI
Sbjct: 278 TMNLEKATVMILEKLNLIEAIKSHDVVGGSELPWRKSLHPERSKESIRPIFWQHRKYSYI 337
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
SRT W++FP+GRWGDS S A+
Sbjct: 338 SRTATWDEFPNGRWGDSRSPAF 359
[103][TOP]
>UniRef100_B8BRT9 Methylenetetrahydrofolate reductase (Fragment) n=1
Tax=Thalassiosira pseudonana CCMP1335 RepID=B8BRT9_THAPS
Length = 574
Score = 125 bits (315), Expect = 1e-27
Identities = 64/145 (44%), Positives = 90/145 (62%), Gaps = 8/145 (5%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG----ITS 169
+Y ++M FC +P+ + L I+ +DEAVK G EMC++IL+ G +
Sbjct: 208 SYSSLVKMTQFCGISVPSAVMDRLSNIRLDDEAVKQVGCKIVAEMCEQILSAGLEVDVDG 267
Query: 170 LHLYTLNVDKSAIGILMNLGLIDESKISRS----LPWRRPANVFRTKEDVRPIFWANRPK 337
H YTLN+++S IL +LG S+ +RS LPW+ A R+KEDVRPI W+NRPK
Sbjct: 268 FHFYTLNLERSTTRILTSLGAGSISEQARSTRRVLPWKPSAMENRSKEDVRPINWSNRPK 327
Query: 338 SYISRTKGWNDFPHGRWGDSHSAAY 412
SY+ RT W++FP+GRWGDS S A+
Sbjct: 328 SYVMRTDDWDEFPNGRWGDSTSPAF 352
[104][TOP]
>UniRef100_A3LUC7 Methylenetetrahydrofolate reductase n=1 Tax=Pichia stipitis
RepID=A3LUC7_PICST
Length = 613
Score = 124 bits (312), Expect = 2e-27
Identities = 61/142 (42%), Positives = 87/142 (61%), Gaps = 6/142 (4%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R A + + IP LEPIKD+D V+ G ++MC K+L G + LH Y
Sbjct: 218 YAAFVRRAKWSQIAIPPHFLEVLEPIKDDDYLVREKGTELVSQMCTKLLQSGFVNHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLIDESKISRS-----LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++++ I IL L +I+ K + LPWR+ + R+KE +RPIFW NR SYI
Sbjct: 278 TMNLERATIMILETLNIIEPVKAHENTGGDELPWRKSLHPQRSKETIRPIFWQNRKYSYI 337
Query: 347 SRTKGWNDFPHGRWGDSHSAAY 412
+RT W++FP+GRWGDS S A+
Sbjct: 338 TRTATWDEFPNGRWGDSRSPAF 359
[105][TOP]
>UniRef100_Q4P5K1 Methylenetetrahydrofolate reductase n=1 Tax=Ustilago maydis
RepID=Q4P5K1_USTMA
Length = 650
Score = 123 bits (309), Expect = 6e-27
Identities = 60/138 (43%), Positives = 84/138 (60%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG--ITSLHL 178
Y GF R T +P AL+P++D+D+ V+ G EMCKKI+ G I+ LH+
Sbjct: 235 YGGFQRATARFGTLVPQYFHDALDPVRDDDQKVREIGTRLVGEMCKKIVGTGLGISGLHI 294
Query: 179 YTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
YT+N++K + +L LGL LPW R +E +RPIFWANR KSY++RT+
Sbjct: 295 YTMNLEKGSRMLLDYLGLTPSVNQVSPLPWTPSLTPKRREEKIRPIFWANRAKSYVNRTE 354
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GRWGD+ S AY
Sbjct: 355 TWDEFPNGRWGDARSPAY 372
[106][TOP]
>UniRef100_Q6FU20 Methylenetetrahydrofolate reductase n=1 Tax=Candida glabrata
RepID=Q6FU20_CANGA
Length = 600
Score = 123 bits (308), Expect = 7e-27
Identities = 65/144 (45%), Positives = 93/144 (64%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y FLR A + + KIP LEP+KD+D+ V+ G +MC+KIL G + LH+Y
Sbjct: 223 YAAFLRRAQWGQIKIPQAFLDVLEPVKDDDQLVRDKGSELIVDMCQKILNSGYVKHLHIY 282
Query: 182 TLNVDKSAIGILMNLGLI-DESKISR----SLPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL LGL+ ES+++ SLPWR+ N R E+VRPIFW RP SY+
Sbjct: 283 TMNLEKAPLIILEKLGLLPSESEVNANPLASLPWRKSLNPKRKNEEVRPIFWKRRPYSYV 342
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 343 ARTSQWAMDEFPNGRFGDSSSPAF 366
[107][TOP]
>UniRef100_A7TTE9 Methylenetetrahydrofolate reductase n=1 Tax=Vanderwaltozyma
polyspora DSM 70294 RepID=A7TTE9_VANPO
Length = 612
Score = 123 bits (308), Expect = 7e-27
Identities = 60/150 (40%), Positives = 89/150 (59%), Gaps = 14/150 (9%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y FLR +C ++P L P+ D+DE V+ G +MC+++L G+ S LHLY
Sbjct: 211 YAAFLRRCSWCGVRVPDNFLQRLAPVSDDDELVREIGTQLVVDMCRRLLESGVVSHLHLY 270
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSL-----------PWRRPANVFRTKEDVRPIFWAN 328
T+N+++ + IL LGL+ E+ +S+ PWRR N R E+VRPIFW +
Sbjct: 271 TMNLERPPLVILERLGLLPEASAEQSIDTFTNEPPAVVPWRRSLNPQRRNEEVRPIFWKS 330
Query: 329 RPKSYISRTKGW--NDFPHGRWGDSHSAAY 412
RP SY++RT W ++FP+GR+GDS S A+
Sbjct: 331 RPYSYVARTSQWAADEFPNGRFGDSSSPAF 360
[108][TOP]
>UniRef100_Q6CKM1 Methylenetetrahydrofolate reductase n=1 Tax=Kluyveromyces lactis
RepID=Q6CKM1_KLULA
Length = 604
Score = 122 bits (307), Expect = 9e-27
Identities = 60/147 (40%), Positives = 89/147 (60%), Gaps = 10/147 (6%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHL 178
+Y F+R +C+ +P LEP+KD+D+ V+ G E+C+K+L G + LH+
Sbjct: 222 SYPSFIRRTQWCQINVPDNFLELLEPVKDDDQLVRDVGTELMVELCQKLLDSGYVNHLHM 281
Query: 179 YTLNVDKSAIGILMNLGLIDESKISRS-------LPWRRPANVFRTKEDVRPIFWANRPK 337
YT+N++K+++ IL L L+ S + + LPWR+ N R E VRPIFW RP
Sbjct: 282 YTMNLEKASLMILEKLDLLKRSNVGKDVIEPLEPLPWRKSLNPKRRNELVRPIFWQKRPY 341
Query: 338 SYISRTKGWN--DFPHGRWGDSHSAAY 412
SY++RT WN +FP+GR+GDS S AY
Sbjct: 342 SYVARTSLWNEDEFPNGRFGDSSSPAY 368
[109][TOP]
>UniRef100_B6QPH8 Methylenetetrahydrofolate reductase n=1 Tax=Penicillium marneffei
ATCC 18224 RepID=B6QPH8_PENMQ
Length = 607
Score = 122 bits (307), Expect = 9e-27
Identities = 60/139 (43%), Positives = 87/139 (62%), Gaps = 3/139 (2%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R + + K +IP + LEP+K +D V+ G EMC+K+LA G I LH Y
Sbjct: 218 YDAFMRRSNWTKIRIPPDWLEKLEPVKADDAKVREVGTKLVAEMCRKLLASGHIHHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRT 355
T+N+ ++ IL L L+ +E+ + + LPWRR + R EDVRPIFW NR SYI+RT
Sbjct: 278 TMNLAQATRLILEELRLLPSEEAPLQKPLPWRRSLGLRRRSEDVRPIFWRNRNASYIART 337
Query: 356 KGWNDFPHGRWGDSHSAAY 412
W+++P+GRW D+ S A+
Sbjct: 338 ADWDEYPNGRWTDARSPAF 356
[110][TOP]
>UniRef100_B8M3Q9 Methylenetetrahydrofolate reductase n=1 Tax=Talaromyces stipitatus
ATCC 10500 RepID=B8M3Q9_TALSN
Length = 607
Score = 122 bits (305), Expect = 2e-26
Identities = 60/139 (43%), Positives = 87/139 (62%), Gaps = 3/139 (2%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F+R + + K +IP + LEP+K +D V+ G EMC+K+LA G I LH Y
Sbjct: 218 YDAFMRRSNWTKIRIPPDWLDKLEPVKADDAKVREIGTKLVAEMCRKLLASGQIHHLHFY 277
Query: 182 TLNVDKSAIGILMNLGLI--DESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRT 355
T+N+ ++ IL L L+ +E+ + + LPWRR + R EDVRPIFW NR SYI+RT
Sbjct: 278 TMNLAQATRLILEELRLLPSEEAPLHKPLPWRRSLGLRRRSEDVRPIFWRNRNASYIART 337
Query: 356 KGWNDFPHGRWGDSHSAAY 412
W+++P+GRW D+ S A+
Sbjct: 338 ADWDEYPNGRWTDARSPAF 356
[111][TOP]
>UniRef100_C4R2Q6 Methylenetetrahydrofolate reductase n=1 Tax=Pichia pastoris GS115
RepID=C4R2Q6_PICPG
Length = 603
Score = 121 bits (304), Expect = 2e-26
Identities = 61/151 (40%), Positives = 87/151 (57%), Gaps = 15/151 (9%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y F R A +C+ +P+ L+ KD+D V+ G +MC K++ G + LH Y
Sbjct: 204 YASFSRRAKWCQINVPSWFQKQLDASKDDDSEVRCLGTQLVADMCLKLVESGYVNHLHFY 263
Query: 182 TLNVDKSAIGILMNLGLID--------------ESKISRSLPWRRPANVFRTKEDVRPIF 319
T+N++KS I +L L LID ES+++ +PWRR N R E +RPIF
Sbjct: 264 TMNLEKSTIMVLEKLQLIDTHNQPVASVRDCGVESQVT--VPWRRSLNPTRVNESIRPIF 321
Query: 320 WANRPKSYISRTKGWNDFPHGRWGDSHSAAY 412
W+NR +YISRT W++FP+GRWGDS S A+
Sbjct: 322 WSNRKFTYISRTSNWDEFPNGRWGDSRSPAF 352
[112][TOP]
>UniRef100_A7S5W8 Methylenetetrahydrofolate reductase n=1 Tax=Nematostella vectensis
RepID=A7S5W8_NEMVE
Length = 619
Score = 121 bits (303), Expect = 3e-26
Identities = 60/133 (45%), Positives = 92/133 (69%), Gaps = 1/133 (0%)
Frame = +2
Query: 17 LRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLYTLNV 193
LR F K+P E+ L+ K++ EA++A+GI AT+MC+++ A G + +HLYTLN+
Sbjct: 243 LRKMNFA-VKVPNEILEVLKSGKEDLEAIQAFGIQHATKMCQELFASGKVQGIHLYTLNI 301
Query: 194 DKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDF 373
+K + IL NL + E ++++ LPW+ + R+ EDVRPIFWA+RP+SY+ RT W D
Sbjct: 302 EKPVMSILENLKISKEPELNK-LPWQ--LSDVRSGEDVRPIFWASRPRSYLIRTSNWEDM 358
Query: 374 PHGRWGDSHSAAY 412
P+GRWG+S SA++
Sbjct: 359 PNGRWGNSSSASF 371
[113][TOP]
>UniRef100_A7S360 Methylenetetrahydrofolate reductase n=1 Tax=Nematostella vectensis
RepID=A7S360_NEMVE
Length = 612
Score = 121 bits (303), Expect = 3e-26
Identities = 60/127 (47%), Positives = 83/127 (65%), Gaps = 2/127 (1%)
Frame = +2
Query: 38 KTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLYTLNVDKSAIGI 214
+ ++P + L+ IKDND A++ YG+ A MC+++L G+ LH YTLN + + I
Sbjct: 216 RLEVPKSIMDDLQTIKDNDVAIRNYGVQKAINMCRELLDSGLVPGLHFYTLNREVATREI 275
Query: 215 LMNLGL-IDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWG 391
L LGL + SR LPWR AN R EDVRPIFWA+RPKSY+ RT W++FP+GRWG
Sbjct: 276 LTALGLWCMDPAASRPLPWRASANQKRFTEDVRPIFWASRPKSYLYRTSDWDEFPNGRWG 335
Query: 392 DSHSAAY 412
+S + A+
Sbjct: 336 NSSAPAF 342
[114][TOP]
>UniRef100_Q10258 Methylenetetrahydrofolate reductase 1 n=1 Tax=Schizosaccharomyces
pombe RepID=MTHR1_SCHPO
Length = 603
Score = 120 bits (301), Expect = 5e-26
Identities = 59/141 (41%), Positives = 83/141 (58%), Gaps = 5/141 (3%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
+ F+R A + KIP L P+KD+DE V+ G+ EMC+K++A GIT LH YT
Sbjct: 218 WDSFIRRAKWSGVKIPQHFMDTLVPVKDDDEGVRERGVELIVEMCRKLIASGITRLHFYT 277
Query: 185 LNVDKSAIGILMNLGLIDES-----KISRSLPWRRPANVFRTKEDVRPIFWANRPKSYIS 349
+N++K+ I+ LGL+DE+ + + R E VRPIFW R +SY+S
Sbjct: 278 MNLEKAVKMIIERLGLLDENLAPIVDTNNVELTNASSQDRRINEGVRPIFWRTRNESYVS 337
Query: 350 RTKGWNDFPHGRWGDSHSAAY 412
RT W++ PHGRWGDS S A+
Sbjct: 338 RTDQWDELPHGRWGDSRSPAF 358
[115][TOP]
>UniRef100_Q5K8Q9 Methylenetetrahydrofolate reductase n=1 Tax=Filobasidiella
neoformans RepID=Q5K8Q9_CRYNE
Length = 617
Score = 119 bits (299), Expect = 8e-26
Identities = 57/125 (45%), Positives = 77/125 (61%), Gaps = 3/125 (2%)
Frame = +2
Query: 47 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAH---GITSLHLYTLNVDKSAIGIL 217
+P+ AL P++ +DE V+ G +MCK IL + GI LH+YTLN++K A +L
Sbjct: 236 VPSHFYEALNPVRGDDEKVRQVGTKLVADMCKTILDNKEAGIKGLHIYTLNLEKGARMLL 295
Query: 218 MNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDS 397
LG + LPWR R +E +RPIFWANR +SY+SRT W++FP+GRWGDS
Sbjct: 296 RELGFEGRREQIAPLPWRPSLTPSRREETIRPIFWANRTRSYLSRTADWDEFPNGRWGDS 355
Query: 398 HSAAY 412
S AY
Sbjct: 356 RSPAY 360
[116][TOP]
>UniRef100_C8Z8C5 Met13p n=1 Tax=Saccharomyces cerevisiae EC1118 RepID=C8Z8C5_YEAST
Length = 600
Score = 119 bits (299), Expect = 8e-26
Identities = 63/144 (43%), Positives = 92/144 (63%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y FLR A + + IP ++ L+PIKD+DE V+ G + EMC+K+L G S LH+Y
Sbjct: 223 YAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIY 282
Query: 182 TLNVDKSAIGILMNLGLID-ESKISRS----LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY+
Sbjct: 283 TMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYV 342
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 343 ARTSQWAVDEFPNGRFGDSSSPAF 366
[117][TOP]
>UniRef100_B5VIK4 Methylenetetrahydrofolate reductase n=1 Tax=Saccharomyces
cerevisiae AWRI1631 RepID=B5VIK4_YEAS6
Length = 411
Score = 119 bits (299), Expect = 8e-26
Identities = 63/144 (43%), Positives = 92/144 (63%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y FLR A + + IP ++ L+PIKD+DE V+ G + EMC+K+L G S LH+Y
Sbjct: 34 YAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIY 93
Query: 182 TLNVDKSAIGILMNLGLID-ESKISRS----LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY+
Sbjct: 94 TMNLEKAPLMILERLNILPMESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYV 153
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 154 ARTSQWAVDEFPNGRFGDSSSPAF 177
[118][TOP]
>UniRef100_B3LHI5 Methylenetetrahydrofolate reductase n=1 Tax=Saccharomyces
cerevisiae RM11-1a RepID=B3LHI5_YEAS1
Length = 600
Score = 119 bits (299), Expect = 8e-26
Identities = 63/144 (43%), Positives = 92/144 (63%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y FLR A + + IP ++ L+PIKD+DE V+ G + EMC+K+L G S LH+Y
Sbjct: 223 YAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIY 282
Query: 182 TLNVDKSAIGILMNLGLID-ESKISRS----LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY+
Sbjct: 283 TMNLEKAPLMILERLNILPMESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYV 342
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 343 ARTSQWAVDEFPNGRFGDSSSPAF 366
[119][TOP]
>UniRef100_P53128 Methylenetetrahydrofolate reductase 2 n=3 Tax=Saccharomyces
cerevisiae RepID=MTHR2_YEAST
Length = 600
Score = 119 bits (299), Expect = 8e-26
Identities = 63/144 (43%), Positives = 92/144 (63%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y FLR A + + IP ++ L+PIKD+DE V+ G + EMC+K+L G S LH+Y
Sbjct: 223 YAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIY 282
Query: 182 TLNVDKSAIGILMNLGLID-ESKISRS----LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ + IL L ++ ES+ + LPWR+ N R E+VRPIFW RP SY+
Sbjct: 283 TMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYV 342
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 343 ARTSQWAVDEFPNGRFGDSSSPAF 366
[120][TOP]
>UniRef100_A8Q9P3 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS
7966 RepID=A8Q9P3_MALGO
Length = 515
Score = 118 bits (296), Expect = 2e-25
Identities = 55/118 (46%), Positives = 77/118 (65%), Gaps = 3/118 (2%)
Frame = +2
Query: 68 ALEPIKDNDEAVKAYGIHFATEMCKKILAH---GITSLHLYTLNVDKSAIGILMNLGLID 238
AL+P+K++DE V+ G +MCKKIL H I +H+YT+N+++ + +L LGL
Sbjct: 164 ALDPVKEDDEQVRIVGTRLVGDMCKKILEHPDLDIHGVHIYTMNLERGSRMLLEYLGLTP 223
Query: 239 ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSAAY 412
+ LPWR R +E++RPIFWANR KSYI RT W++FP+GRWGD+ S AY
Sbjct: 224 SVQQLHPLPWRPSLTPKRREENIRPIFWANRAKSYIDRTDAWDEFPNGRWGDARSPAY 281
[121][TOP]
>UniRef100_A6RBU9 Methylenetetrahydrofolate reductase n=1 Tax=Ajellomyces capsulatus
NAm1 RepID=A6RBU9_AJECN
Length = 619
Score = 117 bits (292), Expect = 5e-25
Identities = 55/124 (44%), Positives = 82/124 (66%), Gaps = 2/124 (1%)
Frame = +2
Query: 47 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 226
IP + ALEP+K++D AV+ G MC+K+LA GI LH YT+N+ ++ +L L
Sbjct: 218 IPPDWLEALEPVKNDDVAVRNLGKSLVANMCRKMLAAGIHHLHFYTMNLQQATKMVLGEL 277
Query: 227 GLIDESK--ISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSH 400
LI K + + LPWR+ + R +EDVRPIFW +R +SY++RT+ W+++P+GRW DS
Sbjct: 278 ELIPSHKTPLQKPLPWRQSLGLGRREEDVRPIFWRHRHQSYVARTQTWDEYPNGRWTDSR 337
Query: 401 SAAY 412
S A+
Sbjct: 338 SPAF 341
[122][TOP]
>UniRef100_Q8MQE7 Methylenetetrahydrofolate reductase n=1 Tax=Caenorhabditis elegans
RepID=Q8MQE7_CAEEL
Length = 642
Score = 115 bits (288), Expect = 2e-24
Identities = 60/138 (43%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y+ R+A + +IP + LEPIK +D+AV+ YG EMC+++L +G S+HLY
Sbjct: 254 YESIKRIAKLSQLEIPQHILDDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLY 313
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWR-RPANVFRTKEDVRPIFWANRPKSYISRTK 358
T+N + S IL +LGL + + R PW+ R + R E VRPI+W+ RP+SYI+RT+
Sbjct: 314 TMNREGSIREILKSLGLW-KLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTR 372
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+ FP+GRWG+S S A+
Sbjct: 373 DWDQFPNGRWGNSSSPAF 390
[123][TOP]
>UniRef100_Q17693 Probable methylenetetrahydrofolate reductase n=1 Tax=Caenorhabditis
elegans RepID=MTHR_CAEEL
Length = 663
Score = 115 bits (288), Expect = 2e-24
Identities = 60/138 (43%), Positives = 89/138 (64%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y+ R+A + +IP + LEPIK +D+AV+ YG EMC+++L +G S+HLY
Sbjct: 275 YESIKRIAKLSQLEIPQHILDDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLY 334
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWR-RPANVFRTKEDVRPIFWANRPKSYISRTK 358
T+N + S IL +LGL + + R PW+ R + R E VRPI+W+ RP+SYI+RT+
Sbjct: 335 TMNREGSIREILKSLGLW-KLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTR 393
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+ FP+GRWG+S S A+
Sbjct: 394 DWDQFPNGRWGNSSSPAF 411
[124][TOP]
>UniRef100_UPI0000123E6B Hypothetical protein CBG12960 n=1 Tax=Caenorhabditis briggsae AF16
RepID=UPI0000123E6B
Length = 662
Score = 114 bits (285), Expect = 3e-24
Identities = 60/138 (43%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y+ R+A + +IP + LEPIK +D+AV+ YG EMC+++L +G S+HLY
Sbjct: 276 YESIKRIAKLSQLEIPEHILEDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGSAPSIHLY 335
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWR-RPANVFRTKEDVRPIFWANRPKSYISRTK 358
T+N + S IL LGL + + R PW+ R + R E VRPI+W+ RP+SYI+RT+
Sbjct: 336 TMNREGSIREILKALGLW-KLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTR 394
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+ FP+GRWG+S S A+
Sbjct: 395 DWDQFPNGRWGNSSSPAF 412
[125][TOP]
>UniRef100_A8XGR9 Methylenetetrahydrofolate reductase n=1 Tax=Caenorhabditis briggsae
RepID=A8XGR9_CAEBR
Length = 724
Score = 114 bits (285), Expect = 3e-24
Identities = 60/138 (43%), Positives = 88/138 (63%), Gaps = 2/138 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT-SLHLY 181
Y+ R+A + +IP + LEPIK +D+AV+ YG EMC+++L +G S+HLY
Sbjct: 326 YESIKRIAKLSQLEIPEHILEDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGSAPSIHLY 385
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWR-RPANVFRTKEDVRPIFWANRPKSYISRTK 358
T+N + S IL LGL + + R PW+ R + R E VRPI+W+ RP+SYI+RT+
Sbjct: 386 TMNREGSIREILKALGLW-KLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTR 444
Query: 359 GWNDFPHGRWGDSHSAAY 412
W+ FP+GRWG+S S A+
Sbjct: 445 DWDQFPNGRWGNSSSPAF 462
[126][TOP]
>UniRef100_C5E412 Methylenetetrahydrofolate reductase n=1 Tax=Zygosaccharomyces
rouxii CBS 732 RepID=C5E412_ZYGRC
Length = 599
Score = 114 bits (285), Expect = 3e-24
Identities = 62/144 (43%), Positives = 87/144 (60%), Gaps = 8/144 (5%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITS-LHLY 181
Y FLR A +C IP E L+PIKD+D+ V+ G +C+K+L G S LH+Y
Sbjct: 222 YAAFLRRANWCDVHIPQEYFDRLDPIKDDDQLVREVGTDLIVSLCQKLLDSGYVSHLHIY 281
Query: 182 TLNVDKSAIGILMNLGLI---DESKISRS--LPWRRPANVFRTKEDVRPIFWANRPKSYI 346
T+N++K+ IL + L+ DE + LPWR+ N R E+VRPIFW RP SY+
Sbjct: 282 TMNLEKAPQMILDRMELLPSHDEPLDNHLAILPWRKSLNPQRRNEEVRPIFWQRRPYSYV 341
Query: 347 SRTKGW--NDFPHGRWGDSHSAAY 412
+RT W ++FP+GR+GDS S A+
Sbjct: 342 ARTSQWSVDEFPNGRFGDSSSPAF 365
[127][TOP]
>UniRef100_B6K4Z7 Methylenetetrahydrofolate reductase n=1 Tax=Schizosaccharomyces
japonicus yFS275 RepID=B6K4Z7_SCHJY
Length = 605
Score = 109 bits (272), Expect = 1e-22
Identities = 57/146 (39%), Positives = 86/146 (58%), Gaps = 9/146 (6%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
++ F R + +IP ALEP+KD+D V+ G EMC+K++ +GIT LH Y
Sbjct: 218 SWSTFNRRCEWSGVRIPQHFIDALEPLKDDDALVREKGSELMAEMCQKLVDNGITRLHFY 277
Query: 182 TLNVDKSAIGILMNLGL----IDESKISRSLPWRRPANVF-----RTKEDVRPIFWANRP 334
T+N++K+ I+ +GL I+ K + R P+ + R E VRP+FW R
Sbjct: 278 TMNLEKATKMIIEKMGLLNQYIETPKNELTSHIRSPSQLQFLDNPRPNETVRPMFWKTRS 337
Query: 335 KSYISRTKGWNDFPHGRWGDSHSAAY 412
+S+ISRT+ W++FP+GRWGDS S A+
Sbjct: 338 QSFISRTEQWDEFPNGRWGDSRSPAF 363
[128][TOP]
>UniRef100_UPI000151BABB hypothetical protein PGUG_04648 n=1 Tax=Pichia guilliermondii ATCC
6260 RepID=UPI000151BABB
Length = 355
Score = 99.8 bits (247), Expect = 9e-20
Identities = 48/99 (48%), Positives = 66/99 (66%), Gaps = 6/99 (6%)
Frame = +2
Query: 134 MCKKILAHGITS-LHLYTLNVDKSAIGILMNLGLIDESKISR-----SLPWRRPANVFRT 295
MC+K++ + S LH YT+N++++ I IL NL LI+ K LPWR+ + R+
Sbjct: 1 MCQKLIDSKVVSHLHFYTMNLERATIMILENLNLIEPVKDHEIIGGVDLPWRKSLHPSRS 60
Query: 296 KEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSAAY 412
KE +RPIFW NR SYISRT W++FP+GRWGDS S A+
Sbjct: 61 KESIRPIFWQNRKYSYISRTSTWDEFPNGRWGDSRSPAF 99
[129][TOP]
>UniRef100_A5DMZ7 Methylenetetrahydrofolate reductase n=1 Tax=Pichia guilliermondii
RepID=A5DMZ7_PICGU
Length = 355
Score = 99.8 bits (247), Expect = 9e-20
Identities = 48/99 (48%), Positives = 66/99 (66%), Gaps = 6/99 (6%)
Frame = +2
Query: 134 MCKKILAHGITS-LHLYTLNVDKSAIGILMNLGLIDESKISR-----SLPWRRPANVFRT 295
MC+K++ + S LH YT+N++++ I IL NL LI+ K LPWR+ + R+
Sbjct: 1 MCQKLIDSKVVSHLHFYTMNLERATIMILENLNLIEPVKDHEIIGGVDLPWRKSLHPSRS 60
Query: 296 KEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSAAY 412
KE +RPIFW NR SYISRT W++FP+GRWGDS S A+
Sbjct: 61 KESIRPIFWQNRKYSYISRTSTWDEFPNGRWGDSRSPAF 99
[130][TOP]
>UniRef100_A7QB31 Methylenetetrahydrofolate reductase n=1 Tax=Vitis vinifera
RepID=A7QB31_VITVI
Length = 93
Score = 77.8 bits (190), Expect(2) = 1e-15
Identities = 37/54 (68%), Positives = 42/54 (77%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGI 163
N KGFL M GFCKTK+ TAALEPIKDN++AV YGIH TEMCKK+L +GI
Sbjct: 5 NSKGFLGMTGFCKTKV----TAALEPIKDNEKAVNTYGIHLGTEMCKKVLGNGI 54
Score = 28.5 bits (62), Expect(2) = 1e-15
Identities = 12/18 (66%), Positives = 16/18 (88%)
Frame = +3
Query: 270 DALQMFSVLRKMFAQFSG 323
+ LQM SVL+KMF+Q+SG
Sbjct: 73 NGLQMSSVLKKMFSQYSG 90
[131][TOP]
>UniRef100_B7GB47 Methylenetetrahydrofolate reductase (Fragment) n=1
Tax=Phaeodactylum tricornutum CCAP 1055/1
RepID=B7GB47_PHATR
Length = 376
Score = 83.6 bits (205), Expect = 6e-15
Identities = 39/76 (51%), Positives = 54/76 (71%), Gaps = 1/76 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y GF++MA FCKT++P L A +E IKD+ AVKA+G+ F EMC+ +LA G ++ LH Y
Sbjct: 301 YAGFVKMAKFCKTRVPETLRARMEAIKDDAAAVKAFGVEFGVEMCRTLLASGHVSVLHFY 360
Query: 182 TLNVDKSAIGILMNLG 229
TLN++K G+L LG
Sbjct: 361 TLNLEKVVYGVLDALG 376
[132][TOP]
>UniRef100_C9S7I3 Methylenetetrahydrofolate reductase n=1 Tax=Verticillium albo-atrum
VaMs.102 RepID=C9S7I3_9PEZI
Length = 312
Score = 76.6 bits (187), Expect = 8e-13
Identities = 31/58 (53%), Positives = 43/58 (74%)
Frame = +2
Query: 239 ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSAAY 412
E + ++LPW++ + R +EDVRPIFW R KSYI RT+ W++FP+GRWGDS S A+
Sbjct: 21 ERPLKQALPWKQSLGLGRREEDVRPIFWKGRNKSYILRTQDWDEFPNGRWGDSRSPAF 78
[133][TOP]
>UniRef100_B9XQY3 Methylenetetrahydrofolate reductase n=1 Tax=bacterium Ellin514
RepID=B9XQY3_9BACT
Length = 303
Score = 74.3 bits (181), Expect = 4e-12
Identities = 34/71 (47%), Positives = 45/71 (63%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R++ C K+P+ L + LE + DNDEA AYGI +ATE C ++L G LH+YTLN
Sbjct: 231 RISALCGAKLPSRLVSCLEKLADNDEAAAAYGIDYATEQCAELLREGAPGLHMYTLNKAP 290
Query: 200 SAIGILMNLGL 232
S I +L NL L
Sbjct: 291 STIQVLKNLAL 301
[134][TOP]
>UniRef100_B8BVS6 Methylenetetrahydrofolate reductase n=1 Tax=Thalassiosira
pseudonana CCMP1335 RepID=B8BVS6_THAPS
Length = 383
Score = 73.9 bits (180), Expect = 5e-12
Identities = 32/76 (42%), Positives = 48/76 (63%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
Y GF +M FCKT++P L ++ IKD+ +AVK +G+ F E+ + +L G+ LH YT
Sbjct: 240 YPGFKKMTKFCKTRVPKSLEERMDAIKDDADAVKKFGVEFGAEISRNLLDSGVKILHFYT 299
Query: 185 LNVDKSAIGILMNLGL 232
LN++K GI LG+
Sbjct: 300 LNLEKVVYGITDELGI 315
[135][TOP]
>UniRef100_Q4P1E8 Methylenetetrahydrofolate reductase n=1 Tax=Ustilago maydis
RepID=Q4P1E8_USTMA
Length = 684
Score = 73.6 bits (179), Expect = 7e-12
Identities = 51/164 (31%), Positives = 75/164 (45%), Gaps = 27/164 (16%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKI-LAHGITSLHL 178
NY F RM CK ++P + ALEPIK +D AVK YG+ + M +I L + HL
Sbjct: 280 NYSSFRRMTNLCKVQVPQLILDALEPIKSDDAAVKEYGVSLSIHMVGRIFLETDVRGFHL 339
Query: 179 YTLNVDKSAIGILMNLGL----------------------IDESK---ISRSLPWRRPAN 283
+LN++KS IL LG ++ +K +S P +
Sbjct: 340 CSLNLEKSIERILEGLGWKTDVGAQQESDARLRGIPAHLHLENTKNQMLSDRTGTNTPKD 399
Query: 284 VFRTKEDVRPIFWANRPKSY-ISRTKGWNDFPHGRWGDSHSAAY 412
T ++ A SY + T W++FP+GR+GDS S A+
Sbjct: 400 FKVTTQEALARTLARTSSSYQVPETSTWDEFPNGRYGDSRSPAF 443
[136][TOP]
>UniRef100_B4D0K5 Methylenetetrahydrofolate reductase n=1 Tax=Chthoniobacter flavus
Ellin428 RepID=B4D0K5_9BACT
Length = 297
Score = 72.0 bits (175), Expect = 2e-11
Identities = 32/73 (43%), Positives = 45/73 (61%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R C K+PA+ L+ + +DEAV AYGI +ATE C +L G+ LH YTLN +
Sbjct: 224 RFVSLCGAKLPAQFLRRLDELDGDDEAVAAYGIEYATEQCASLLEFGVPGLHFYTLNKAR 283
Query: 200 SAIGILMNLGLID 238
S + I+ NLGL++
Sbjct: 284 STVQIVRNLGLLN 296
[137][TOP]
>UniRef100_A8QAM7 Methylenetetrahydrofolate reductase n=1 Tax=Malassezia globosa CBS
7966 RepID=A8QAM7_MALGO
Length = 589
Score = 72.0 bits (175), Expect = 2e-11
Identities = 45/138 (32%), Positives = 65/138 (47%), Gaps = 1/138 (0%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAH-GITSLHL 178
NY F RMA C P ++ LEPIK +D VK +GIH + +M K I GI + HL
Sbjct: 244 NYTMFRRMANLCGVHTPEDVLEQLEPIKMDDAKVKEHGIHLSIDMIKSIREQTGIRAFHL 303
Query: 179 YTLNVDKSAIGILMNLGLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTK 358
YTLN++KSA ++ L + + S IS +
Sbjct: 304 YTLNLEKSATCVIKVLADVPDQSAS------------------------------ISGSV 333
Query: 359 GWNDFPHGRWGDSHSAAY 412
W++FP+GR+ D+ S A+
Sbjct: 334 TWDEFPNGRYTDARSPAF 351
[138][TOP]
>UniRef100_B0CSW4 Methylenetetrahydrofolate reductase n=1 Tax=Laccaria bicolor
S238N-H82 RepID=B0CSW4_LACBS
Length = 602
Score = 68.6 bits (166), Expect = 2e-10
Identities = 47/150 (31%), Positives = 72/150 (48%), Gaps = 14/150 (9%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKI-LAHGITSLHLY 181
Y F+R+ C T++PA +T L PI +D+ VK YG+ A +M +++ L GI H
Sbjct: 220 YASFVRLTKLCGTRVPACITEDLAPISHDDQLVKDYGVKLAVQMIRRLRLEGGIQGFHFC 279
Query: 182 TLNVDKSAIGILMNLGLIDESKISRSLPWRR-PANVFRTKEDVRPIFWANRPKSYISRTK 358
TLN++KS +L L ++ + P P ++ T A + IS T
Sbjct: 280 TLNLEKSVQRVLETLRWAGDTPGTMEPPAEMGPPDLLITPTSATDT--ATSTLATISVTD 337
Query: 359 G------------WNDFPHGRWGDSHSAAY 412
G W+DFP+GR+GD S A+
Sbjct: 338 GEAGRGELNNAATWDDFPNGRFGDFKSPAF 367
[139][TOP]
>UniRef100_A9UZU5 Methylenetetrahydrofolate reductase n=1 Tax=Monosiga brevicollis
RepID=A9UZU5_MONBE
Length = 332
Score = 66.2 bits (160), Expect = 1e-09
Identities = 31/77 (40%), Positives = 45/77 (58%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N GF RM FCK++ PA L AA+E D+ EA++ + ++C+ + A G LH Y
Sbjct: 250 NAGGFKRMTAFCKSRTPAALRAAVEAAGDDKEAIRKVAVEHGAQLCRDLQAAGAPGLHFY 309
Query: 182 TLNVDKSAIGILMNLGL 232
TLN++K + IL L L
Sbjct: 310 TLNLEKVTLAILDALNL 326
[140][TOP]
>UniRef100_Q0EWI5 Methylenetetrahydrofolate reductase (Fragment) n=1
Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EWI5_9PROT
Length = 251
Score = 65.1 bits (157), Expect = 2e-09
Identities = 30/71 (42%), Positives = 43/71 (60%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C IPA L ++PI+D+ EAVKA GI A + C+++L G+ LH Y
Sbjct: 173 NYDQIVRFSSMCGASIPAWLHEQMQPIRDDLEAVKALGIELAAKQCRELLQAGVPGLHFY 232
Query: 182 TLNVDKSAIGI 214
TLN ++ I I
Sbjct: 233 TLNKSEATIAI 243
[141][TOP]
>UniRef100_A8NEV2 Methylenetetrahydrofolate reductase n=1 Tax=Coprinopsis cinerea
okayama7#130 RepID=A8NEV2_COPC7
Length = 617
Score = 65.1 bits (157), Expect = 2e-09
Identities = 49/163 (30%), Positives = 75/163 (46%), Gaps = 27/163 (16%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAH-GITSLHLY 181
Y F R+ C TK+P+ L A L PIK++D+ VK YG+ +A + ++ GI H
Sbjct: 217 YATFARLTKLCGTKVPSTLEADLLPIKNDDQLVKDYGVKYAVKTIHRLRNEGGIQGFHFC 276
Query: 182 TLNVDKSAIGILMNL----GLID--ESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSY 343
TLN++KS +L L G++ ++K+ P N + + P N S
Sbjct: 277 TLNLEKSVQRVLEELKWRTGVVPAVQNKLIADSPDALSQNTLDSNLLITPTSATNVATSV 336
Query: 344 --------ISRT------------KGWNDFPHGRWGDSHSAAY 412
+SRT W+DFP+GR+GD S A+
Sbjct: 337 LTTSVLGTVSRTLPEAGRGELNDAATWDDFPNGRFGDFKSPAF 379
[142][TOP]
>UniRef100_UPI000194E904 PREDICTED: similar to 5,10-methylenetetrahydrofolate reductase
(NADPH), partial n=1 Tax=Taeniopygia guttata
RepID=UPI000194E904
Length = 345
Score = 64.7 bits (156), Expect = 3e-09
Identities = 30/80 (37%), Positives = 47/80 (58%), Gaps = 1/80 (1%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHLY 181
Y ++ K ++P E+ +EPIKDND A++ YG+ A MC+++L G + LH Y
Sbjct: 264 YHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGVELAVSMCRELLDSGMVHGLHFY 323
Query: 182 TLNVDKSAIGILMNLGLIDE 241
TLN + + +L LGL +E
Sbjct: 324 TLNREVATTEVLKRLGLWNE 343
[143][TOP]
>UniRef100_A1U549 Methylenetetrahydrofolate reductase n=1 Tax=Marinobacter aquaeolei
VT8 RepID=A1U549_MARAV
Length = 289
Score = 64.3 bits (155), Expect = 4e-09
Identities = 29/84 (34%), Positives = 47/84 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ +R + C +IP + LE D+ ++++ +G TEMC+K+L G LH Y
Sbjct: 205 NFSSLVRFSDMCGAEIPRWIRKQLEAYGDDTDSIRKFGEEVVTEMCQKLLKAGAPGLHFY 264
Query: 182 TLNVDKSAIGILMNLGLIDESKIS 253
TLN + ++ I NLG+ D KI+
Sbjct: 265 TLNQAEPSLSIWKNLGISDREKIA 288
[144][TOP]
>UniRef100_Q5KN82 Methylenetetrahydrofolate reductase n=1 Tax=Filobasidiella
neoformans RepID=Q5KN82_CRYNE
Length = 633
Score = 64.3 bits (155), Expect = 4e-09
Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 1/85 (1%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHG-ITSLHL 178
NY F R+ K +P +T+ L+PI +D VK YG AT+M +I+ G + +HL
Sbjct: 220 NYASFRRLVNLTKCPVPDSITSDLQPISSDDATVKRYGAELATKMVSQIIESGLVPGVHL 279
Query: 179 YTLNVDKSAIGILMNLGLIDESKIS 253
TLN++KS IL NLG SK S
Sbjct: 280 CTLNLEKSVRMILDNLGWSAASKTS 304
[145][TOP]
>UniRef100_B3PGF0 Methylenetetrahydrofolate reductase n=1 Tax=Cellvibrio japonicus
Ueda107 RepID=B3PGF0_CELJU
Length = 282
Score = 63.9 bits (154), Expect = 5e-09
Identities = 30/78 (38%), Positives = 46/78 (58%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NYK R + C +IP L ALE D++E+++A+G+ TE+C+ +L + LH Y
Sbjct: 202 NYKNLTRFSDTCGAEIPRWLRKALENYGDDEESLRAFGVDLVTELCEVLLENEAPGLHFY 261
Query: 182 TLNVDKSAIGILMNLGLI 235
T+N + I+ NLGLI
Sbjct: 262 TMNQTEPTAQIVRNLGLI 279
[146][TOP]
>UniRef100_A3JC11 Methylenetetrahydrofolate reductase n=1 Tax=Marinobacter sp. ELB17
RepID=A3JC11_9ALTE
Length = 318
Score = 63.9 bits (154), Expect = 5e-09
Identities = 30/83 (36%), Positives = 46/83 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ +R + C +IP + LE D+ E+++ +G T MC+K+L G LH Y
Sbjct: 234 NFSSLVRFSDMCGAEIPRWIRKQLEAYGDDSESIRQFGEEVVTRMCEKLLKAGAPGLHFY 293
Query: 182 TLNVDKSAIGILMNLGLIDESKI 250
TLN + ++GI NLGL + KI
Sbjct: 294 TLNQVEPSLGIWKNLGLGEREKI 316
[147][TOP]
>UniRef100_A4HQF9 Methylenetetrahydrofolate reductase n=1 Tax=Leishmania braziliensis
RepID=A4HQF9_LEIBR
Length = 309
Score = 63.5 bits (153), Expect = 7e-09
Identities = 30/81 (37%), Positives = 45/81 (55%), Gaps = 2/81 (2%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT--SLHL 178
Y GF RM CKT++P ++ +E +K+N EA+K YG+ +M ++I A G+ LH
Sbjct: 229 YAGFTRMVSLCKTRVPGDVKKRVEELKENPEALKEYGVEQCVQMIERIRASGLDYHHLHF 288
Query: 179 YTLNVDKSAIGILMNLGLIDE 241
YTLN +L L + E
Sbjct: 289 YTLNSSAQTFQVLKRLNALVE 309
[148][TOP]
>UniRef100_A6EZ72 Methylenetetrahydrofolate reductase n=1 Tax=Marinobacter algicola
DG893 RepID=A6EZ72_9ALTE
Length = 289
Score = 62.8 bits (151), Expect = 1e-08
Identities = 29/84 (34%), Positives = 46/84 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ R + C +IP + LE D+ ++++ +G TEMC K+LA G LH Y
Sbjct: 205 NFSNLTRFSDMCGAEIPRWIRKQLEAYGDDSDSIRKFGEEVVTEMCAKLLAAGAPGLHFY 264
Query: 182 TLNVDKSAIGILMNLGLIDESKIS 253
TLN + ++ I NLG+ + KI+
Sbjct: 265 TLNQAEPSLSIWKNLGIGEREKIA 288
[149][TOP]
>UniRef100_Q0VL81 Methylenetetrahydrofolate reductase n=1 Tax=Alcanivorax borkumensis
SK2 RepID=Q0VL81_ALCBS
Length = 275
Score = 62.4 bits (150), Expect = 2e-08
Identities = 31/77 (40%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N LR + C +P L + L IKD+D AVKA+G T +C+++LA G LH Y
Sbjct: 199 NVANLLRFSNTCGADVPRWLQSKLNDIKDDDAAVKAFGEEVVTRLCERLLAMGAPGLHFY 258
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + IL NLG+
Sbjct: 259 TMNQAGPNLRILDNLGM 275
[150][TOP]
>UniRef100_B5HCL5 Methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
pristinaespiralis ATCC 25486 RepID=B5HCL5_STRPR
Length = 305
Score = 62.4 bits (150), Expect = 2e-08
Identities = 31/75 (41%), Positives = 43/75 (57%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R A PAEL + +KD+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 231 RFATLSNAHFPAELKERILAVKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNST 290
Query: 200 SAIGILMNLGLIDES 244
+ + I NLGL ++S
Sbjct: 291 ATLEIYENLGLHEQS 305
[151][TOP]
>UniRef100_B4X3B0 Methylenetetrahydrofolate reductase n=1 Tax=Alcanivorax sp. DG881
RepID=B4X3B0_9GAMM
Length = 275
Score = 62.0 bits (149), Expect = 2e-08
Identities = 31/77 (40%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N LR + C +P L + L IKD+D AVKA+G T +C+++LA G LH Y
Sbjct: 199 NVANLLRFSSTCGADVPRWLQSKLNDIKDDDVAVKAFGEEVVTRLCERLLAMGAPGLHFY 258
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + IL NLG+
Sbjct: 259 TMNQAGPNLRILDNLGM 275
[152][TOP]
>UniRef100_A8UU31 Methylenetetrahydrofolate reductase n=1 Tax=Hydrogenivirga sp.
128-5-R1-1 RepID=A8UU31_9AQUI
Length = 298
Score = 61.2 bits (147), Expect = 3e-08
Identities = 26/71 (36%), Positives = 39/71 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+K + A C IP L +EP++D E V G+ FA + C+ +L +G+ LH Y
Sbjct: 213 NFKQIKKFASMCGATIPQSLIEKMEPVEDKPEEVAKIGVEFAVKQCEDLLRNGVPGLHFY 272
Query: 182 TLNVDKSAIGI 214
TLN K+ + I
Sbjct: 273 TLNRSKATLNI 283
[153][TOP]
>UniRef100_UPI0001699FF2 5,10-methylenetetrahydrofolate reductase n=1 Tax=Endoriftia
persephone 'Hot96_1+Hot96_2' RepID=UPI0001699FF2
Length = 120
Score = 60.5 bits (145), Expect = 6e-08
Identities = 26/77 (33%), Positives = 44/77 (57%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C T+IP + LE D+ E+++A+G+ TE+C+++L G LH Y
Sbjct: 44 NYSSLVRFSDACGTEIPRWIRKRLEGFSDDLESIRAFGLEVVTELCRRLLEGGAPGLHFY 103
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + + + LGL
Sbjct: 104 TMNQSEPTLRLCDRLGL 120
[154][TOP]
>UniRef100_A4VRF8 Methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas stutzeri
A1501 RepID=A4VRF8_PSEU5
Length = 283
Score = 60.5 bits (145), Expect = 6e-08
Identities = 30/77 (38%), Positives = 44/77 (57%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ ++++A+G TEMC+K+LA G LH Y
Sbjct: 205 NYSKLARFSDACGAEIPRWVRKQLEAYGDDMQSIQAFGEQVITEMCQKLLAGGAPGLHFY 264
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + ++ I NLGL
Sbjct: 265 TLNQAEPSLAIWNNLGL 281
[155][TOP]
>UniRef100_Q84CU6 Methylenetetrahydrofolate reductase (Fragment) n=1 Tax=uncultured
bacterium RepID=Q84CU6_9BACT
Length = 253
Score = 59.7 bits (143), Expect = 1e-07
Identities = 32/86 (37%), Positives = 47/86 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R +G C +IP L LE D+ +++A GI +E+C+ +LA G+ SLH Y
Sbjct: 168 NYTQLARFSGVCGAEIPRWLRLRLEAYADDMPSLRALGIDVVSELCEVLLAGGVPSLHFY 227
Query: 182 TLNVDKSAIGILMNLGLIDESKISRS 259
TLN I+ N+GL D + R+
Sbjct: 228 TLNQAGIISTIINNVGLEDATTQKRN 253
[156][TOP]
>UniRef100_B2V845 Methylenetetrahydrofolate reductase n=1 Tax=Sulfurihydrogenibium
sp. YO3AOP1 RepID=B2V845_SULSY
Length = 291
Score = 59.3 bits (142), Expect = 1e-07
Identities = 28/75 (37%), Positives = 36/75 (48%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ + A C IP E+ E DN E K GI FAT C ++ HG+ LH Y
Sbjct: 213 NFNQIKKFASLCGATIPEEVVQKFEKYADNPEETKKIGIEFATLQCMDLIKHGVKGLHFY 272
Query: 182 TLNVDKSAIGILMNL 226
TLN + I I N+
Sbjct: 273 TLNKSDATIKIYENI 287
[157][TOP]
>UniRef100_A4FAF8 Methylenetetrahydrofolate reductase n=1 Tax=Saccharopolyspora
erythraea NRRL 2338 RepID=A4FAF8_SACEN
Length = 294
Score = 59.3 bits (142), Expect = 1e-07
Identities = 25/63 (39%), Positives = 42/63 (66%)
Frame = +2
Query: 47 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 226
+P + LEP+ D+ A +A G+ ATE+C++++A G+ +LH YTLN K+ ++ NL
Sbjct: 228 VPPAVLERLEPLADDAAAFRAEGVVLATELCERLIAEGVPALHFYTLNRSKATREVVSNL 287
Query: 227 GLI 235
GL+
Sbjct: 288 GLL 290
[158][TOP]
>UniRef100_C5BTQ6 Methylenetetrahydrofolate reductase n=1 Tax=Teredinibacter turnerae
T7901 RepID=C5BTQ6_TERTT
Length = 282
Score = 58.9 bits (141), Expect = 2e-07
Identities = 28/79 (35%), Positives = 42/79 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY+ R + C +IP + L DN E+++A+ TE+C +L +G LH Y
Sbjct: 204 NYQNIARFSDACGAEIPRWIRKRLNDFGDNQESLQAFTTDLVTELCATLLENGAPGLHFY 263
Query: 182 TLNVDKSAIGILMNLGLID 238
T+N + IL NLGL+D
Sbjct: 264 TMNQVEPTRTILTNLGLVD 282
[159][TOP]
>UniRef100_Q6J6A1 Methylenetetrahydrofolate reductase n=1 Tax=Collimonas fungivorans
RepID=Q6J6A1_9BURK
Length = 284
Score = 58.9 bits (141), Expect = 2e-07
Identities = 26/77 (33%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C T+IP + L D+ ++++A+G+ T++C+++LA G LH Y
Sbjct: 208 NYSQLMRFSDMCGTEIPRWIRLKLASYGDDSDSIRAFGLDVVTQLCERLLAGGAPGLHFY 267
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I I L L
Sbjct: 268 TLNQSPATIAIWQRLKL 284
[160][TOP]
>UniRef100_Q4Q0B9 Methylenetetrahydrofolate reductase n=1 Tax=Leishmania major
RepID=Q4Q0B9_LEIMA
Length = 309
Score = 58.9 bits (141), Expect = 2e-07
Identities = 29/81 (35%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT--SLHL 178
Y GF+RM CKT +P+++ +E +K+N + +K YG+ +M + I A G+ LH
Sbjct: 229 YAGFVRMVSLCKTSVPSDVKKRVEELKENPDGLKEYGVEQCVQMIECIRASGLDYHHLHF 288
Query: 179 YTLNVDKSAIGILMNLGLIDE 241
YTLN IL L + E
Sbjct: 289 YTLNNSAQIFKILKRLNALVE 309
[161][TOP]
>UniRef100_O67422 5,10-methylenetetrahydrofolate reductase n=1 Tax=Aquifex aeolicus
RepID=METF_AQUAE
Length = 296
Score = 58.9 bits (141), Expect = 2e-07
Identities = 27/71 (38%), Positives = 36/71 (50%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+K + A C IP L LE ++D E VK GI FA C ++ HG+ LH Y
Sbjct: 213 NFKQIRKFASLCGATIPQSLIEKLEKVEDKPEEVKKIGIEFAINQCLDLIEHGVPGLHFY 272
Query: 182 TLNVDKSAIGI 214
TLN + + I
Sbjct: 273 TLNKSDATLKI 283
[162][TOP]
>UniRef100_Q21NJ7 Methylenetetrahydrofolate reductase n=1 Tax=Saccharophagus
degradans 2-40 RepID=Q21NJ7_SACD2
Length = 297
Score = 58.5 bits (140), Expect = 2e-07
Identities = 28/79 (35%), Positives = 42/79 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY+ R + C IP + +E DN EA+ ++GI + +E+C +L G LH Y
Sbjct: 203 NYRNLARFSDSCGADIPRWMRKRMESFGDNQEALISFGIDWISELCDTLLDAGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGLID 238
T+N + I+ NLGL D
Sbjct: 263 TMNQTEPTATIIKNLGLED 281
[163][TOP]
>UniRef100_C1DUH1 Methylenetetrahydrofolate reductase n=1 Tax=Sulfurihydrogenibium
azorense Az-Fu1 RepID=C1DUH1_SULAA
Length = 291
Score = 58.5 bits (140), Expect = 2e-07
Identities = 27/75 (36%), Positives = 38/75 (50%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ + A C IP ++ E DN E K GI FAT+ C+ +L +G+ LH Y
Sbjct: 213 NFNQIRKFASLCGATIPEDVVKLFEKYADNPEETKKIGIEFATKQCEDLLKNGVKGLHFY 272
Query: 182 TLNVDKSAIGILMNL 226
TLN + I I N+
Sbjct: 273 TLNKSDATIKIYNNI 287
[164][TOP]
>UniRef100_UPI0001B4BBD1 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
lividans TK24 RepID=UPI0001B4BBD1
Length = 292
Score = 58.2 bits (139), Expect = 3e-07
Identities = 29/71 (40%), Positives = 39/71 (54%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ PAEL + KD+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 216 RLPKLSNASFPAELKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNST 275
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 276 ATLEIYENLGL 286
[165][TOP]
>UniRef100_Q9S2V3 Methylenetetrahydrofolate reductase n=1 Tax=Streptomyces coelicolor
RepID=Q9S2V3_STRCO
Length = 307
Score = 58.2 bits (139), Expect = 3e-07
Identities = 29/71 (40%), Positives = 39/71 (54%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ PAEL + KD+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 231 RLPKLSNASFPAELKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNST 290
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 291 ATLEIYENLGL 301
[166][TOP]
>UniRef100_C0QT51 Methylenetetrahydrofolate reductase n=1 Tax=Persephonella marina
EX-H1 RepID=C0QT51_PERMH
Length = 293
Score = 58.2 bits (139), Expect = 3e-07
Identities = 26/71 (36%), Positives = 41/71 (57%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N++ + A C IP +L LE ++++ E V GI +ATE C+ +L +G+ LH Y
Sbjct: 214 NFRQIEKFAVMCGATIPKDLVEKLEKVENSPEEVAKIGIDYATEQCEDLLKNGVKGLHFY 273
Query: 182 TLNVDKSAIGI 214
TLN K+ + I
Sbjct: 274 TLNKSKATVEI 284
[167][TOP]
>UniRef100_B8KLD1 Methylenetetrahydrofolate reductase n=1 Tax=gamma proteobacterium
NOR5-3 RepID=B8KLD1_9GAMM
Length = 278
Score = 58.2 bits (139), Expect = 3e-07
Identities = 25/77 (32%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP ++ LE D+ ++++A+GI T++C+ +L G +H Y
Sbjct: 202 NYANLARFSKNCGAEIPRWISKRLEGFADDQDSIRAFGIDVVTQLCQTLLESGAPGIHFY 261
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + + I NLGL
Sbjct: 262 TMNQTQPTLQICRNLGL 278
[168][TOP]
>UniRef100_O54235 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
lividans RepID=METF_STRLI
Length = 307
Score = 58.2 bits (139), Expect = 3e-07
Identities = 29/71 (40%), Positives = 39/71 (54%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ PAEL + KD+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 231 RLPKLSNASFPAELKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNST 290
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 291 ATLEIYENLGL 301
[169][TOP]
>UniRef100_UPI0001744B6A 5,10-methylenetetrahydrofolate reductase n=1 Tax=Verrucomicrobium
spinosum DSM 4136 RepID=UPI0001744B6A
Length = 314
Score = 57.4 bits (137), Expect = 5e-07
Identities = 30/74 (40%), Positives = 42/74 (56%), Gaps = 1/74 (1%)
Frame = +2
Query: 11 GFLRMAGFCK-TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTL 187
G RMA ++PA L AL ++ + AV G+H ATE C ++L HG++ +HLYTL
Sbjct: 223 GLRRMAELAGGARVPARLLKALMKVQHDPAAVLEVGLHHATEQCSELLHHGVSGIHLYTL 282
Query: 188 NVDKSAIGILMNLG 229
N + IL LG
Sbjct: 283 NQAGPILEILKRLG 296
[170][TOP]
>UniRef100_Q476T6 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia eutropha
JMP134 RepID=Q476T6_RALEJ
Length = 276
Score = 57.4 bits (137), Expect = 5e-07
Identities = 25/77 (32%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C +++P + LE D+ E+++A+G+ T +C+++LA G+ LH Y
Sbjct: 200 NYSQLMRFSDMCGSEVPRWVAKRLESFGDDRESIRAFGLDVVTALCERLLAGGVPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I L L
Sbjct: 260 TLNAAGATKAIWQRLKL 276
[171][TOP]
>UniRef100_C9NJ42 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
flavogriseus ATCC 33331 RepID=C9NJ42_9ACTO
Length = 305
Score = 57.4 bits (137), Expect = 5e-07
Identities = 29/75 (38%), Positives = 41/75 (54%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R A +P+ L + KD+ AV++ GI FATE C K+L+ G+ LH TLN
Sbjct: 231 RFAQLSNASLPSALKERILAAKDDPAAVRSIGIEFATEFCAKLLSEGVPGLHFITLNNST 290
Query: 200 SAIGILMNLGLIDES 244
+ + I NLGL +S
Sbjct: 291 ATLEIYENLGLHKQS 305
[172][TOP]
>UniRef100_C7QA95 5,10-methylenetetrahydrofolate reductase n=1 Tax=Catenulispora
acidiphila DSM 44928 RepID=C7QA95_CATAD
Length = 315
Score = 57.4 bits (137), Expect = 5e-07
Identities = 26/71 (36%), Positives = 42/71 (59%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ G PA+L +L ++ + AV+A G+ + T MC+++LA G+ LH TLN+
Sbjct: 231 RITGLTGQAFPADLERSLMAVEGDKAAVRAVGVDWTTRMCERLLAEGVPGLHFITLNMST 290
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 291 ATLEIYRNLGL 301
[173][TOP]
>UniRef100_C6P2D6 Methylenetetrahydrofolate reductase n=1 Tax=Sideroxydans
lithotrophicus ES-1 RepID=C6P2D6_9GAMM
Length = 280
Score = 57.4 bits (137), Expect = 5e-07
Identities = 26/70 (37%), Positives = 43/70 (61%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R + C +IP + +E D+ E+V+A+G+ T++C+K++A G SLH YTLN
Sbjct: 209 RFSDNCGAEIPRWMRKTMEGYGDDSESVQAFGLDVVTQLCEKLIAGGAPSLHFYTLNQAN 268
Query: 200 SAIGILMNLG 229
+++ IL LG
Sbjct: 269 ASLEILKRLG 278
[174][TOP]
>UniRef100_A4IC95 Methylenetetrahydrofolate reductase n=1 Tax=Leishmania infantum
RepID=A4IC95_LEIIN
Length = 309
Score = 57.4 bits (137), Expect = 5e-07
Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Frame = +2
Query: 5 YKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGIT--SLHL 178
Y GF+RM CKT +P+++ +E +K+N + +K YG+ +M + I G+ LH
Sbjct: 229 YAGFVRMVSLCKTSVPSDVKKRVEELKENPDGLKEYGVEQCVQMIECIRTSGLDYHHLHF 288
Query: 179 YTLNVDKSAIGILMNLGLIDE 241
YTLN +L L + E
Sbjct: 289 YTLNNSAQTFKVLKRLNALVE 309
[175][TOP]
>UniRef100_UPI0001B519C1 putative 5,10-methylenetetrahydrofolate reductase n=1
Tax=Streptomyces hygroscopicus ATCC 53653
RepID=UPI0001B519C1
Length = 290
Score = 57.0 bits (136), Expect = 6e-07
Identities = 30/81 (37%), Positives = 42/81 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N K R A P EL + +KD+ AV++ GI +ATE+C +++A I LH
Sbjct: 210 NVKQIERFAQLSNAAFPPELAERILAVKDDAAAVRSIGIDYATELCARLMAEEIPGLHFI 269
Query: 182 TLNVDKSAIGILMNLGLIDES 244
TLN + + I NLGL S
Sbjct: 270 TLNHSTATLEIYKNLGLHQRS 290
[176][TOP]
>UniRef100_B6J3R7 Methylenetetrahydrofolate reductase n=1 Tax=Coxiella burnetii
CbuG_Q212 RepID=B6J3R7_COXB2
Length = 290
Score = 57.0 bits (136), Expect = 6e-07
Identities = 26/75 (34%), Positives = 45/75 (60%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
++ +R + C T+IP L LE K++ ++KAYG+ T++C+ ++A+G+ LH Y
Sbjct: 203 DFDKLVRFSKTCATEIPRWLYKRLESYKNDKASLKAYGVEVVTKLCEDLIAYGVPGLHFY 262
Query: 182 TLNVDKSAIGILMNL 226
TLN + I+ NL
Sbjct: 263 TLNQCEPTQTIIENL 277
[177][TOP]
>UniRef100_A9N9C8 Methylenetetrahydrofolate reductase n=2 Tax=Coxiella burnetii
RepID=A9N9C8_COXBR
Length = 290
Score = 57.0 bits (136), Expect = 6e-07
Identities = 26/75 (34%), Positives = 45/75 (60%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
++ +R + C T+IP L LE K++ ++KAYG+ T++C+ ++A+G+ LH Y
Sbjct: 203 DFDKLVRFSKTCATEIPRWLYKRLESYKNDKASLKAYGVEVVTKLCEDLIAYGVPGLHFY 262
Query: 182 TLNVDKSAIGILMNL 226
TLN + I+ NL
Sbjct: 263 TLNQCEPTQTIIENL 277
[178][TOP]
>UniRef100_C4FKN7 Methylenetetrahydrofolate reductase n=1 Tax=Sulfurihydrogenibium
yellowstonense SS-5 RepID=C4FKN7_9AQUI
Length = 292
Score = 57.0 bits (136), Expect = 6e-07
Identities = 28/75 (37%), Positives = 35/75 (46%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ + A C IP E+ E DN E K GI FAT C ++ HG LH Y
Sbjct: 213 NFNQIKKFASLCGATIPEEVVQKFEKYADNPEETKKIGIEFATLQCIDLIKHGAKGLHFY 272
Query: 182 TLNVDKSAIGILMNL 226
TLN + I I N+
Sbjct: 273 TLNKSDATIKIYENI 287
[179][TOP]
>UniRef100_B6J6H7 Methylenetetrahydrofolate reductase n=2 Tax=Coxiella burnetii
RepID=B6J6H7_COXB1
Length = 290
Score = 57.0 bits (136), Expect = 6e-07
Identities = 26/75 (34%), Positives = 45/75 (60%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
++ +R + C T+IP L LE K++ ++KAYG+ T++C+ ++A+G+ LH Y
Sbjct: 203 DFDKLVRFSKTCATEIPRWLYKRLESYKNDKASLKAYGVEVVTKLCEDLIAYGVPGLHFY 262
Query: 182 TLNVDKSAIGILMNL 226
TLN + I+ NL
Sbjct: 263 TLNQCEPTQTIIENL 277
[180][TOP]
>UniRef100_Q1LS18 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia metallidurans
CH34 RepID=Q1LS18_RALME
Length = 276
Score = 56.6 bits (135), Expect = 8e-07
Identities = 25/77 (32%), Positives = 41/77 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C ++P + LE D+ EA++A+G+ T++C ++L G+ LH Y
Sbjct: 200 NYSQLMRFSEMCGAEVPRWVAKRLESFGDDKEAIRAFGLDVVTDLCTRLLEAGVPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I L L
Sbjct: 260 TLNAAGATKAIWQRLKL 276
[181][TOP]
>UniRef100_C1DIB8 Methylenetetrahydrofolate reductase n=1 Tax=Azotobacter vinelandii
DJ RepID=C1DIB8_AZOVD
Length = 281
Score = 56.6 bits (135), Expect = 8e-07
Identities = 28/77 (36%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C ++P + LE D+ E+++A+G T MC+K+L G LH Y
Sbjct: 203 NYSKLARFSDACGAELPRWVRKQLEAYGDDLESIQAFGEQVVTAMCEKLLEGGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + ++ I NLGL
Sbjct: 263 TLNQAEPSLAIWNNLGL 279
[182][TOP]
>UniRef100_B2AGG4 Methylenetetrahydrofolate reductase n=1 Tax=Cupriavidus taiwanensis
RepID=B2AGG4_CUPTR
Length = 276
Score = 56.6 bits (135), Expect = 8e-07
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C ++P + LE D+ E+++A+G+ T +C+++LA G+ LH Y
Sbjct: 200 NYSQLMRFSEMCGAEVPRWVAKRLESFGDDRESIRAFGLDVVTALCERLLAAGVPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I L L
Sbjct: 260 TLNAAGATKAIWQRLKL 276
[183][TOP]
>UniRef100_Q2L158 Methylenetetrahydrofolate reductase n=1 Tax=Bordetella avium 197N
RepID=Q2L158_BORA1
Length = 280
Score = 56.2 bits (134), Expect = 1e-06
Identities = 23/75 (30%), Positives = 41/75 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C ++P + L D+ +++A+G+ T++C+ +L HG+ LH Y
Sbjct: 204 NYSQLSRFSEMCGAELPRWIRLRLAEFGDDKASIRAFGVDVVTKLCQTLLDHGVPGLHFY 263
Query: 182 TLNVDKSAIGILMNL 226
TLN ++ + I NL
Sbjct: 264 TLNQSEATLSIWKNL 278
[184][TOP]
>UniRef100_C4BW20 Methylenetetrahydrofolate reductase n=1 Tax=Sebaldella termitidis
ATCC 33386 RepID=C4BW20_9FUSO
Length = 292
Score = 56.2 bits (134), Expect = 1e-06
Identities = 29/78 (37%), Positives = 43/78 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N K R+ C KIP +L L +DN+EA+ GI +ATE ++L+ GI +H+Y
Sbjct: 210 NAKQIKRITSLCNCKIPKKLERILNAYEDNNEAMYQAGIAYATEQIIELLSAGIKGIHIY 269
Query: 182 TLNVDKSAIGILMNLGLI 235
T+N + IL N+ I
Sbjct: 270 TMNKTNAVKEILENISSI 287
[185][TOP]
>UniRef100_A4A9E4 Methylenetetrahydrofolate reductase n=1 Tax=Congregibacter
litoralis KT71 RepID=A4A9E4_9GAMM
Length = 278
Score = 56.2 bits (134), Expect = 1e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP ++ LE D+ E+++A+GI T++C+ +L +H Y
Sbjct: 202 NYANLARFSKNCGAEIPRWISKRLEGFADDQESIRAFGIDVVTQLCQTLLESDAPGIHFY 261
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + + I NLGL
Sbjct: 262 TMNQAQPTLQICRNLGL 278
[186][TOP]
>UniRef100_A4XPF2 Methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas mendocina
ymp RepID=A4XPF2_PSEMY
Length = 281
Score = 55.8 bits (133), Expect = 1e-06
Identities = 26/77 (33%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ ++++A+G TEMC+++L G LH Y
Sbjct: 203 NYSKLARFSDACGAEIPRWVRKQLEAYGDDADSIRAFGEQVITEMCERLLQGGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
++N+ ++ I NLGL
Sbjct: 263 SMNLAGPSLAIWNNLGL 279
[187][TOP]
>UniRef100_C0DWJ7 Methylenetetrahydrofolate reductase n=1 Tax=Eikenella corrodens
ATCC 23834 RepID=C0DWJ7_EIKCO
Length = 277
Score = 55.8 bits (133), Expect = 1e-06
Identities = 28/76 (36%), Positives = 38/76 (50%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ R A C +IP L L+ D+ ++KA G+ TEMC ++L HG LH Y
Sbjct: 201 NFSKLARFADMCGAEIPRWLRLKLQSYADDTASIKALGLDVVTEMCGRLLRHGAPGLHFY 260
Query: 182 TLNVDKSAIGILMNLG 229
TLN + I LG
Sbjct: 261 TLNQAGLSSTICQRLG 276
[188][TOP]
>UniRef100_A8V3W7 Methylenetetrahydrofolate reductase n=1 Tax=Hydrogenivirga sp.
128-5-R1-1 RepID=A8V3W7_9AQUI
Length = 230
Score = 55.8 bits (133), Expect = 1e-06
Identities = 27/71 (38%), Positives = 37/71 (52%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+K + A C IP L LE +D E V+ GI +A E C+ +L H + LH Y
Sbjct: 151 NFKQIRKFALMCGATIPEYLVKKLEKYQDIPEEVEKIGIEYAVEQCEDLLKHNVKGLHFY 210
Query: 182 TLNVDKSAIGI 214
TLN K+ + I
Sbjct: 211 TLNKSKATLQI 221
[189][TOP]
>UniRef100_Q82AF8 Methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
avermitilis RepID=Q82AF8_STRAW
Length = 307
Score = 55.5 bits (132), Expect = 2e-06
Identities = 28/71 (39%), Positives = 39/71 (54%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ IP+ L + KD+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 231 RLPQLSNAAIPSVLQERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNST 290
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 291 ATLEIYENLGL 301
[190][TOP]
>UniRef100_Q60CG9 Methylenetetrahydrofolate reductase n=1 Tax=Methylococcus
capsulatus RepID=Q60CG9_METCA
Length = 289
Score = 55.5 bits (132), Expect = 2e-06
Identities = 24/77 (31%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ +R + C IP + LE D+ +A++ +G+ TE+C+++L G LH Y
Sbjct: 210 NHSQLVRFSDLCGADIPRWIRKRLEAFGDDRKAIRTFGLEVVTELCRRLLEQGAPGLHFY 269
Query: 182 TLNVDKSAIGILMNLGL 232
TLN ++ + + LGL
Sbjct: 270 TLNRAEACLEVWKALGL 286
[191][TOP]
>UniRef100_Q1D7X5 Methylenetetrahydrofolate reductase n=1 Tax=Myxococcus xanthus DK
1622 RepID=Q1D7X5_MYXXD
Length = 290
Score = 55.5 bits (132), Expect = 2e-06
Identities = 24/63 (38%), Positives = 34/63 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY+ R C +P L LE +KDN EA+ G+ AT C ++L+ G+ +H Y
Sbjct: 212 NYEQIQRFTRLCGATVPMRLALQLERVKDNPEAMAQLGVAHATVQCMELLSRGVPGIHFY 271
Query: 182 TLN 190
TLN
Sbjct: 272 TLN 274
[192][TOP]
>UniRef100_Q0KF23 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia eutropha H16
RepID=Q0KF23_RALEH
Length = 276
Score = 55.5 bits (132), Expect = 2e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C ++P + LE D+ E+++A+G+ T +C+++LA G+ LH Y
Sbjct: 200 NYTQLMRFSESCGAEVPRWVAKRLESFGDDRESIRAFGLDVVTALCERLLAAGVPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I L L
Sbjct: 260 TLNAAGATKAIWQRLKL 276
[193][TOP]
>UniRef100_A9KD99 Methylenetetrahydrofolate reductase n=1 Tax=Coxiella burnetii
Dugway 5J108-111 RepID=A9KD99_COXBN
Length = 290
Score = 55.5 bits (132), Expect = 2e-06
Identities = 25/64 (39%), Positives = 40/64 (62%)
Frame = +2
Query: 35 CKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGI 214
C T+IP L LE K++ ++KAYG+ T++C+ ++A+G+ LH YTLN + I
Sbjct: 214 CATEIPRWLYKRLESYKNDKASLKAYGVEVVTKLCEDLIAYGVPGLHFYTLNQCEPTQTI 273
Query: 215 LMNL 226
+ NL
Sbjct: 274 IENL 277
[194][TOP]
>UniRef100_UPI0001B4CAB1 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
viridochromogenes DSM 40736 RepID=UPI0001B4CAB1
Length = 307
Score = 55.1 bits (131), Expect = 2e-06
Identities = 27/71 (38%), Positives = 38/71 (53%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ PA L + KD+ AV++ GI +ATE C ++LA G+ LH TLN
Sbjct: 231 RIGSLTNAAFPAALKERILAAKDDPAAVRSIGIEYATEFCARLLAEGVPGLHFITLNNST 290
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 291 ATLEIYENLGL 301
[195][TOP]
>UniRef100_UPI0000E87FC4 metF; 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein n=1 Tax=Methylophilales bacterium HTCC2181
RepID=UPI0000E87FC4
Length = 277
Score = 55.1 bits (131), Expect = 2e-06
Identities = 27/75 (36%), Positives = 43/75 (57%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N K R + C ++IP L LE D+ E++++YGI TE+C+ ++ +G+ S+H Y
Sbjct: 201 NIKQLSRFSANCGSEIPRWLKMKLEDYGDDLESLRSYGIDVITELCETLIQYGVPSVHFY 260
Query: 182 TLNVDKSAIGILMNL 226
TLN I+ NL
Sbjct: 261 TLNQSGIITKIINNL 275
[196][TOP]
>UniRef100_Q8Y389 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia solanacearum
RepID=Q8Y389_RALSO
Length = 276
Score = 55.1 bits (131), Expect = 2e-06
Identities = 26/77 (33%), Positives = 40/77 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N +R + C +IP + LE D+ E+++A+G+ T +C ++LA G LH Y
Sbjct: 200 NSSQLMRFSEMCGAEIPRWIAKRLESFGDDRESIRAFGLDVVTALCDRLLAGGAPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I LGL
Sbjct: 260 TLNAAAATRAIWQRLGL 276
[197][TOP]
>UniRef100_B8KU68 Methylenetetrahydrofolate reductase n=1 Tax=gamma proteobacterium
NOR51-B RepID=B8KU68_9GAMM
Length = 216
Score = 55.1 bits (131), Expect = 2e-06
Identities = 26/79 (32%), Positives = 41/79 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N+ R AG C +IP + + D+ E+V+ +GI T++C + G +H Y
Sbjct: 136 NFTNLERFAGSCGAEIPRWIRQRVAGFGDDQESVRKFGIEVVTQICATLQESGAPGVHFY 195
Query: 182 TLNVDKSAIGILMNLGLID 238
T+N + + I NLGLID
Sbjct: 196 TMNQVEPTLTIAANLGLID 214
[198][TOP]
>UniRef100_B5S7H8 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia solanacearum
RepID=B5S7H8_RALSO
Length = 276
Score = 55.1 bits (131), Expect = 2e-06
Identities = 26/77 (33%), Positives = 40/77 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N +R + C +IP + LE D+ E+++A+G+ T +C ++LA G LH Y
Sbjct: 200 NSSQLMRFSEMCGAEIPRWIAKRLESFGDDRESIRAFGLDVVTALCDRLLAGGAPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I LGL
Sbjct: 260 TLNAAAATRAIWQRLGL 276
[199][TOP]
>UniRef100_A3DBL1 Methylenetetrahydrofolate reductase n=3 Tax=Clostridium
thermocellum RepID=A3DBL1_CLOTH
Length = 291
Score = 55.1 bits (131), Expect = 2e-06
Identities = 25/72 (34%), Positives = 42/72 (58%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ C IPA+L ++ DNDE ++ GI +A+ + ++ +G+ +HL T+N K
Sbjct: 219 RITYLCGASIPAKLVIMMDKYGDNDEDMRKAGIEYASNQIRDLIDNGVDGIHLLTMNRPK 278
Query: 200 SAIGILMNLGLI 235
S IL N+GL+
Sbjct: 279 STREILTNIGLL 290
[200][TOP]
>UniRef100_UPI0001AF04B5 putative 5,10-methylenetetrahydrofolate reductase n=1
Tax=Streptomyces roseosporus NRRL 11379
RepID=UPI0001AF04B5
Length = 290
Score = 54.7 bits (130), Expect = 3e-06
Identities = 27/66 (40%), Positives = 38/66 (57%)
Frame = +2
Query: 47 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 226
+PA L + KD+ AV++ GI FATE C K+L+ G+ LH TLN + + I L
Sbjct: 225 VPASLKERILAAKDDPAAVRSIGIEFATEFCAKLLSEGVPGLHFITLNNSTATLEIYEKL 284
Query: 227 GLIDES 244
GL +S
Sbjct: 285 GLHKQS 290
[201][TOP]
>UniRef100_UPI0001AECE6A putative 5,10-methylenetetrahydrofolate reductase n=1
Tax=Streptomyces albus J1074 RepID=UPI0001AECE6A
Length = 291
Score = 54.7 bits (130), Expect = 3e-06
Identities = 28/74 (37%), Positives = 39/74 (52%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R A P +L + D+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 216 RFAQLSNAVFPRKLEERMRASADDPAAVRSMGIEFATEFCARLLAEGVPGLHFITLNNST 275
Query: 200 SAIGILMNLGLIDE 241
+ + I NLGL D+
Sbjct: 276 ATLEIHENLGLHDD 289
[202][TOP]
>UniRef100_B1VZV3 Methylenetetrahydrofolate reductase n=1 Tax=Streptomyces griseus
subsp. griseus NBRC 13350 RepID=B1VZV3_STRGG
Length = 305
Score = 54.7 bits (130), Expect = 3e-06
Identities = 27/66 (40%), Positives = 38/66 (57%)
Frame = +2
Query: 47 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 226
+PA L + KD+ AV++ GI FATE C K+L+ G+ LH TLN + + I L
Sbjct: 240 VPASLKERILAAKDDPAAVRSIGIEFATEFCAKLLSEGVPGLHFITLNNSTATLEIYEKL 299
Query: 227 GLIDES 244
GL +S
Sbjct: 300 GLHKQS 305
[203][TOP]
>UniRef100_A6T2Y7 Methylenetetrahydrofolate reductase n=1 Tax=Janthinobacterium sp.
Marseille RepID=A6T2Y7_JANMA
Length = 283
Score = 54.7 bits (130), Expect = 3e-06
Identities = 22/63 (34%), Positives = 37/63 (58%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C +IP + L D+ E+++A+G+ T++C+++LA G LH Y
Sbjct: 204 NYSQLMRFSDMCGAEIPRWIRLKLASFGDDSESIRAFGLDVVTDLCERLLAGGAPGLHFY 263
Query: 182 TLN 190
TLN
Sbjct: 264 TLN 266
[204][TOP]
>UniRef100_A3RPV8 Methylenetetrahydrofolate reductase n=2 Tax=Ralstonia solanacearum
RepID=A3RPV8_RALSO
Length = 276
Score = 54.7 bits (130), Expect = 3e-06
Identities = 26/77 (33%), Positives = 40/77 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N +R + C +IP + LE D+ E+++A+G+ T +C ++LA G LH Y
Sbjct: 200 NSSQLMRFSEMCGAEIPRWIAKRLESFGDDRESIRAFGLDVVTALCDRLLAGGAPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I LGL
Sbjct: 260 TLNAAGATRAIWQRLGL 276
[205][TOP]
>UniRef100_UPI0001B55A8B 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces sp.
AA4 RepID=UPI0001B55A8B
Length = 295
Score = 54.3 bits (129), Expect = 4e-06
Identities = 22/55 (40%), Positives = 36/55 (65%)
Frame = +2
Query: 71 LEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNLGLI 235
LEP D+ +A +A G+ + TE+C+K++A G+ LH YT N K+ ++ LGL+
Sbjct: 236 LEPFSDDPKAFRAAGLDWVTELCEKLIAEGVPDLHFYTFNRSKATREVVTRLGLV 290
[206][TOP]
>UniRef100_C6BI03 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia pickettii 12D
RepID=C6BI03_RALP1
Length = 276
Score = 54.3 bits (129), Expect = 4e-06
Identities = 26/77 (33%), Positives = 39/77 (50%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N +R + C ++P + LE D+ E+++A+G+ T MC ++L G LH Y
Sbjct: 200 NSSQLMRFSEMCGAEVPRWIAKRLEGFGDDRESIRAFGLDVVTAMCDRLLQGGAPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN S I LGL
Sbjct: 260 TLNAAGSTRAIWQRLGL 276
[207][TOP]
>UniRef100_B2U776 Methylenetetrahydrofolate reductase n=1 Tax=Ralstonia pickettii 12J
RepID=B2U776_RALPJ
Length = 276
Score = 54.3 bits (129), Expect = 4e-06
Identities = 26/77 (33%), Positives = 39/77 (50%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N +R + C ++P + LE D+ E+++A+G+ T MC ++L G LH Y
Sbjct: 200 NSSQLMRFSEMCGAEVPRWIAKRLEGFGDDRESIRAFGLDVVTAMCDRLLQGGAPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
TLN S I LGL
Sbjct: 260 TLNAAGSTRAIWQRLGL 276
[208][TOP]
>UniRef100_A4G973 Methylenetetrahydrofolate reductase n=1 Tax=Herminiimonas
arsenicoxydans RepID=A4G973_HERAR
Length = 283
Score = 54.3 bits (129), Expect = 4e-06
Identities = 24/77 (31%), Positives = 41/77 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY +R + C +IP + L D+ ++++A+G+ T++C+++LA G LH Y
Sbjct: 204 NYSQLMRFSDMCGAEIPRWIRLKLASYNDDTDSIRAFGLDVVTDLCERLLAGGAPGLHFY 263
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + I L L
Sbjct: 264 TLNQAAATHAIWSRLNL 280
[209][TOP]
>UniRef100_A0Y9Q7 Methylenetetrahydrofolate reductase n=1 Tax=marine gamma
proteobacterium HTCC2143 RepID=A0Y9Q7_9GAMM
Length = 276
Score = 54.3 bits (129), Expect = 4e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE ++ E+V+ +GI T++C+++LA G +H Y
Sbjct: 200 NYHNLARFSKSCGAEIPRWICQRLESFGNDSESVQEFGIEVVTQLCQRLLAEGAPGIHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + I NLG+
Sbjct: 260 TMNQVEPNRQIWKNLGI 276
[210][TOP]
>UniRef100_UPI0001B500FB 5,10-methylenetetrahydrofolate reductase n=1 Tax=Streptomyces
griseoflavus Tu4000 RepID=UPI0001B500FB
Length = 292
Score = 53.9 bits (128), Expect = 5e-06
Identities = 27/71 (38%), Positives = 37/71 (52%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R+ P L + KD+ AV++ GI FATE C ++LA G+ LH TLN
Sbjct: 216 RLPKLSNASFPEALKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNST 275
Query: 200 SAIGILMNLGL 232
+ + I NLGL
Sbjct: 276 ATLEIYENLGL 286
[211][TOP]
>UniRef100_UPI0001744B57 5,10-methylenetetrahydrofolate reductase n=1 Tax=Verrucomicrobium
spinosum DSM 4136 RepID=UPI0001744B57
Length = 300
Score = 53.9 bits (128), Expect = 5e-06
Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Frame = +2
Query: 11 GFLRMAGFCK-TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTL 187
G RMA + PA+L A+ ++ AV+ GIH+ATE C +L H H YTL
Sbjct: 220 GMKRMAELAAGARFPAKLLKAISRCNGDEAAVERVGIHYATEQCADLLDHQADGFHFYTL 279
Query: 188 NVDKSAIGILMNLGLIDESKI 250
N ++ I +LGL D +
Sbjct: 280 NKSRATREIYASLGLKDSRSV 300
[212][TOP]
>UniRef100_Q2SLT5 Methylenetetrahydrofolate reductase n=1 Tax=Hahella chejuensis KCTC
2396 RepID=Q2SLT5_HAHCH
Length = 287
Score = 53.9 bits (128), Expect = 5e-06
Identities = 24/80 (30%), Positives = 42/80 (52%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ +++ +G T +C+++LA G +H Y
Sbjct: 205 NYSNLARFSDMCGAEIPRWVRKQLEAYGDDSASIRKFGEEVVTRLCERLLAAGAPGIHFY 264
Query: 182 TLNVDKSAIGILMNLGLIDE 241
TLN + ++ + NL L D+
Sbjct: 265 TLNQAEPSLAVWDNLNLGDK 284
[213][TOP]
>UniRef100_B8GP49 Methylenetetrahydrofolate reductase n=1 Tax=Thioalkalivibrio sp.
HL-EbGR7 RepID=B8GP49_THISH
Length = 286
Score = 53.9 bits (128), Expect = 5e-06
Identities = 27/77 (35%), Positives = 38/77 (49%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C IP + LE D+ A++A+G T +C+K+L G LH Y
Sbjct: 207 NYTQLARFSDACGADIPRWIRKRLEGFGDDSAAIRAFGEDVVTRLCEKLLEAGAPGLHFY 266
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + I NLGL
Sbjct: 267 TMNQAGPTLAIWNNLGL 283
[214][TOP]
>UniRef100_B1Y645 Methylenetetrahydrofolate reductase n=1 Tax=Leptothrix cholodnii
SP-6 RepID=B1Y645_LEPCP
Length = 279
Score = 53.9 bits (128), Expect = 5e-06
Identities = 24/77 (31%), Positives = 43/77 (55%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N G +R A +IP + L+ D+ ++KA+G+ T++C+++ A G+ +LH Y
Sbjct: 203 NSSGIIRFADGSGAEIPRWIRLRLQSYGDDSASIKAFGLDVVTDLCERLRAGGVPALHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + + I LGL
Sbjct: 263 TMNSSAAVLQICERLGL 279
[215][TOP]
>UniRef100_A4FGJ1 Methylenetetrahydrofolate reductase n=1 Tax=Saccharopolyspora
erythraea NRRL 2338 RepID=A4FGJ1_SACEN
Length = 297
Score = 53.9 bits (128), Expect = 5e-06
Identities = 22/64 (34%), Positives = 42/64 (65%)
Frame = +2
Query: 47 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 226
IP+ +++ L+P+ + +A GI T++C+K++A G+ +LH Y+LN ++ ++ NL
Sbjct: 228 IPSAVSSVLDPLAGDPAGFRAAGIEITTKLCEKLIAEGVPALHFYSLNRAQATREVVSNL 287
Query: 227 GLID 238
GL D
Sbjct: 288 GLSD 291
[216][TOP]
>UniRef100_Q1MYH5 Methylenetetrahydrofolate reductase n=1 Tax=Bermanella marisrubri
RepID=Q1MYH5_9GAMM
Length = 278
Score = 53.9 bits (128), Expect = 5e-06
Identities = 26/77 (33%), Positives = 40/77 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ E+++ +G T+MC+ ++ + + LH Y
Sbjct: 201 NYSKLARFSDACGAEIPRWIRKQLEAYGDDVESIQKFGEEVVTQMCEDLVENDVPGLHFY 260
Query: 182 TLNVDKSAIGILMNLGL 232
TLN I I NLGL
Sbjct: 261 TLNQADPCINIWKNLGL 277
[217][TOP]
>UniRef100_C7RKF7 5,10-methylenetetrahydrofolate reductase n=1 Tax=Candidatus
Accumulibacter phosphatis clade IIA str. UW-1
RepID=C7RKF7_9PROT
Length = 279
Score = 53.9 bits (128), Expect = 5e-06
Identities = 25/77 (32%), Positives = 40/77 (51%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
+Y R + C +IP + LE D+ +++A+G+ T++C+K+LA G LH Y
Sbjct: 202 SYSSLARFSDNCGAEIPRWIRKKLESYGDDSASIRAFGLDVVTQLCEKLLASGAPGLHFY 261
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + LGL
Sbjct: 262 TLNQASLTSTLWQRLGL 278
[218][TOP]
>UniRef100_A5Z3D9 Methylenetetrahydrofolate reductase n=1 Tax=Eubacterium ventriosum
ATCC 27560 RepID=A5Z3D9_9FIRM
Length = 292
Score = 53.9 bits (128), Expect = 5e-06
Identities = 24/63 (38%), Positives = 37/63 (58%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N K RM C IPA+L+ L+ DN EA++ GI +A + ++ AHG+ +H+Y
Sbjct: 210 NKKQIERMVSMCGASIPAKLSKVLQRFGDNHEAMRDAGISYAIDQIIELAAHGVDGVHIY 269
Query: 182 TLN 190
T+N
Sbjct: 270 TMN 272
[219][TOP]
>UniRef100_Q1R0K0 Methylenetetrahydrofolate reductase n=1 Tax=Chromohalobacter
salexigens DSM 3043 RepID=Q1R0K0_CHRSD
Length = 282
Score = 53.5 bits (127), Expect = 7e-06
Identities = 26/75 (34%), Positives = 39/75 (52%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C IP + LE D+ E+++A+G T +C+++L G LH Y
Sbjct: 204 NYTKLARFSDACGADIPRWIRKQLEAYGDDSESIQAFGSEVVTRLCQRLLDGGAPGLHFY 263
Query: 182 TLNVDKSAIGILMNL 226
TLN A+ +L NL
Sbjct: 264 TLNQATPALRVLDNL 278
[220][TOP]
>UniRef100_A1K2Z6 Methylenetetrahydrofolate reductase n=1 Tax=Azoarcus sp. BH72
RepID=A1K2Z6_AZOSB
Length = 277
Score = 53.5 bits (127), Expect = 7e-06
Identities = 24/77 (31%), Positives = 41/77 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
++ R + C +IP + E D+ +A++A+G+ TE+C+K+LA G+ LH Y
Sbjct: 200 SFSKLARFSDACGAEIPRWMRRKFESYGDDADAIRAFGLDVVTELCEKLLAAGVPGLHFY 259
Query: 182 TLNVDKSAIGILMNLGL 232
++N I LGL
Sbjct: 260 SMNQSALTTEICKRLGL 276
[221][TOP]
>UniRef100_UPI0001AF5FB3 5,10-methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas
syringae pv. oryzae str. 1_6 RepID=UPI0001AF5FB3
Length = 281
Score = 53.1 bits (126), Expect = 9e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ ++++A+G T+MC+++L G LH Y
Sbjct: 203 NYSKLARFSDACGAEIPRWIRKQLEAYGDDVQSIQAFGEEVITQMCERLLQGGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + ++ + NL L
Sbjct: 263 TLNQAEPSLAVWNNLQL 279
[222][TOP]
>UniRef100_UPI0001873BC3 5,10-methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas
syringae pv. tomato T1 RepID=UPI0001873BC3
Length = 281
Score = 53.1 bits (126), Expect = 9e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ ++++A+G T+MC+++L G LH Y
Sbjct: 203 NYSKLARFSDACGAEIPRWIRKQLEAYGDDVQSIQAFGEDVITQMCERLLEDGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + ++ + NL L
Sbjct: 263 TLNQAEPSLAVWNNLQL 279
[223][TOP]
>UniRef100_Q4ZZ93 Methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas syringae
pv. syringae B728a RepID=Q4ZZ93_PSEU2
Length = 281
Score = 53.1 bits (126), Expect = 9e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ ++++A+G T+MC+++L G LH Y
Sbjct: 203 NYSKLARFSDACGAEIPRWIRKQLEAYGDDVQSIQAFGEEVITQMCERLLQGGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + ++ + NL L
Sbjct: 263 TLNQAEPSLAVWNNLQL 279
[224][TOP]
>UniRef100_Q48PB6 Methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas syringae
pv. phaseolicola 1448A RepID=Q48PB6_PSE14
Length = 291
Score = 53.1 bits (126), Expect = 9e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ ++++A+G T+MC+++L G LH Y
Sbjct: 213 NYSKLARFSDACGAEIPRWIRKQLEAYGDDVQSIQAFGEEVITQMCERLLQGGTPGLHFY 272
Query: 182 TLNVDKSAIGILMNLGL 232
TLN + ++ + NL L
Sbjct: 273 TLNQAEPSLAVWNNLQL 289
[225][TOP]
>UniRef100_Q3A3T2 Methylenetetrahydrofolate reductase n=1 Tax=Pelobacter carbinolicus
DSM 2380 RepID=Q3A3T2_PELCD
Length = 301
Score = 53.1 bits (126), Expect = 9e-06
Identities = 28/76 (36%), Positives = 43/76 (56%), Gaps = 1/76 (1%)
Frame = +2
Query: 8 KGFLRMAGFCK-TKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYT 184
+G RMA + PA L A++ +D+ E+V+ GIH+ATE C+ +L + + +H YT
Sbjct: 222 EGMKRMAELAAGARFPAPLLRAVDRCQDDPESVRRIGIHWATEQCRDLLDNEVRGIHFYT 281
Query: 185 LNVDKSAIGILMNLGL 232
LN + I LGL
Sbjct: 282 LNNSDATRQIFQCLGL 297
[226][TOP]
>UniRef100_B1J2Y7 Methylenetetrahydrofolate reductase n=1 Tax=Pseudomonas putida W619
RepID=B1J2Y7_PSEPW
Length = 281
Score = 53.1 bits (126), Expect = 9e-06
Identities = 26/77 (33%), Positives = 41/77 (53%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
NY R + C +IP + LE D+ +++A+G T MC+++L G LH Y
Sbjct: 203 NYSKLARFSDACGAEIPRWIRKQLEAYADDTASIQAFGEEVITRMCEQLLQGGAPGLHFY 262
Query: 182 TLNVDKSAIGILMNLGL 232
TLN ++++ I NL L
Sbjct: 263 TLNQAEASLAIWNNLKL 279
[227][TOP]
>UniRef100_A0LTK4 Methylenetetrahydrofolate reductase n=1 Tax=Acidothermus
cellulolyticus 11B RepID=A0LTK4_ACIC1
Length = 331
Score = 53.1 bits (126), Expect = 9e-06
Identities = 34/93 (36%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Frame = +2
Query: 20 RMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDK 199
R A + P EL + + D AV+A GI ATEMC+++L G LH YTLN
Sbjct: 231 RFALLSGDEFPPELADRILAVADQPAAVRAIGIEVATEMCRRLLDEGAPGLHFYTLNRST 290
Query: 200 SAIGILMNLGLIDES----KISRSLPWRRPANV 286
+ I NL L + + K S S P P++V
Sbjct: 291 ATREIYQNLRLSERADRHGKASVSGPGVAPSDV 323
[228][TOP]
>UniRef100_C7NEN8 5,10-methylenetetrahydrofolate reductase n=1 Tax=Leptotrichia
buccalis DSM 1135 RepID=C7NEN8_LEPBD
Length = 291
Score = 53.1 bits (126), Expect = 9e-06
Identities = 27/75 (36%), Positives = 43/75 (57%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N K R+ K +P +L LE DN E++K GI +A+E ++LA+GI +H+Y
Sbjct: 213 NAKQIKRIIELSKCSVPEKLDKLLEKYGDNPESMKKAGIMYASEQIIELLAYGIKGIHIY 272
Query: 182 TLNVDKSAIGILMNL 226
T+N + A I+ N+
Sbjct: 273 TMNKPEIAKEIMKNI 287
[229][TOP]
>UniRef100_A3TKC9 Methylenetetrahydrofolate reductase n=1 Tax=Janibacter sp. HTCC2649
RepID=A3TKC9_9MICO
Length = 295
Score = 53.1 bits (126), Expect = 9e-06
Identities = 25/77 (32%), Positives = 42/77 (54%)
Frame = +2
Query: 2 NYKGFLRMAGFCKTKIPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLY 181
N K RM T +PA + L+ + ++ AV++ G+ ATE+ +++LA G LH
Sbjct: 214 NLKQITRMTELMGTPLPAAVVDRLQAVSEDPAAVRSVGVEIATEIAQRMLAEGAPGLHFI 273
Query: 182 TLNVDKSAIGILMNLGL 232
T+N + + + NLGL
Sbjct: 274 TMNRSTATLEVYENLGL 290