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[1][TOP]
>UniRef100_O81769 Probable diphthine synthase n=1 Tax=Arabidopsis thaliana
           RepID=DPH5_ARATH
          Length = 277

 Score =  276 bits (706), Expect = 5e-73
 Identities = 133/133 (100%), Positives = 133/133 (100%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ
Sbjct: 143 ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 202

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP
Sbjct: 203 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 262

Query: 362 VEEEMLEFYKYKS 400
           VEEEMLEFYKYKS
Sbjct: 263 VEEEMLEFYKYKS 275

[2][TOP]
>UniRef100_A7NSX0 Diphthine synthase n=1 Tax=Vitis vinifera RepID=A7NSX0_VITVI
          Length = 285

 Score =  226 bits (577), Expect = 5e-58
 Identities = 109/132 (82%), Positives = 120/132 (90%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDSFYEKI++NR LGLHTLCLLDIRVKEP+ ESLCRG KKQYEPPRYM++NTAIEQ
Sbjct: 143 ETWRPDSFYEKIQRNRVLGLHTLCLLDIRVKEPSLESLCRG-KKQYEPPRYMTINTAIEQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVEQ  G+S + EDT CVGFARLGSEDQ IVAG+M+QL  VDFGAPLHCLVIVG+THP
Sbjct: 202 LLEVEQMRGESAFCEDTDCVGFARLGSEDQMIVAGSMRQLLKVDFGAPLHCLVIVGKTHP 261

Query: 362 VEEEMLEFYKYK 397
           VEEEML+FYK K
Sbjct: 262 VEEEMLDFYKLK 273

[3][TOP]
>UniRef100_B9GQW4 Diphthine synthase n=1 Tax=Populus trichocarpa RepID=B9GQW4_POPTR
          Length = 285

 Score =  219 bits (559), Expect = 6e-56
 Identities = 103/132 (78%), Positives = 117/132 (88%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+PDSFYEKI++NR LGLHTLCLLDI+VKEPT+ESLCRG KK YEPPR+M++NTAIEQ
Sbjct: 143 DTWKPDSFYEKIQRNRELGLHTLCLLDIKVKEPTWESLCRG-KKLYEPPRFMTINTAIEQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+EQ  G+S Y EDT CVG ARLGSEDQ IVAGTM+QL +VDFGAPLHCLVIVG THP
Sbjct: 202 LLEIEQNRGESAYNEDTNCVGLARLGSEDQKIVAGTMRQLLAVDFGAPLHCLVIVGTTHP 261

Query: 362 VEEEMLEFYKYK 397
           +EEEML  YK K
Sbjct: 262 IEEEMLNMYKLK 273

[4][TOP]
>UniRef100_B9R875 Diphthine synthase n=1 Tax=Ricinus communis RepID=B9R875_RICCO
          Length = 285

 Score =  215 bits (547), Expect = 1e-54
 Identities = 104/130 (80%), Positives = 114/130 (87%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRP SFYEKIK NR LGLHTLCLLDIRVKEP++ESL RG KK YEPPRYM++NTAIEQ
Sbjct: 143 DNWRPGSFYEKIKTNRDLGLHTLCLLDIRVKEPSWESLSRGRKK-YEPPRYMTINTAIEQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVEQK G+S Y EDT CVGFARLGSEDQ IVAGTM+QL +VDFG PLHCLVIVG THP
Sbjct: 202 LLEVEQKRGESAYDEDTNCVGFARLGSEDQMIVAGTMRQLLTVDFGTPLHCLVIVGNTHP 261

Query: 362 VEEEMLEFYK 391
           +EEEML+ YK
Sbjct: 262 LEEEMLDVYK 271

[5][TOP]
>UniRef100_Q10L98 Diphthine synthase n=1 Tax=Oryza sativa Japonica Group
           RepID=Q10L98_ORYSJ
          Length = 274

 Score =  212 bits (540), Expect = 9e-54
 Identities = 103/133 (77%), Positives = 113/133 (84%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDSFYEKI+ NR LGLHTLCLLDIRVKEPT ESLCRG KK YEPPR+MSVNTAI Q
Sbjct: 143 ETWRPDSFYEKIQNNRRLGLHTLCLLDIRVKEPTLESLCRG-KKVYEPPRFMSVNTAISQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVE+  G S YG D+ C+G ARLGS+DQ IVAG MK+L  VDFG PLHCL+IVGETHP
Sbjct: 202 LLEVEELRGGSAYGADSLCIGVARLGSDDQKIVAGPMKKLLDVDFGPPLHCLIIVGETHP 261

Query: 362 VEEEMLEFYKYKS 400
           VEEEM+EF+  KS
Sbjct: 262 VEEEMIEFHMIKS 274

[6][TOP]
>UniRef100_B8APT0 Diphthine synthase n=1 Tax=Oryza sativa Indica Group
           RepID=B8APT0_ORYSI
          Length = 222

 Score =  211 bits (537), Expect = 2e-53
 Identities = 103/133 (77%), Positives = 113/133 (84%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDSFYEKI+ NR LGLHTLCLLDIRVKEPT ESLCRG KK YEPPR+MSVNTAI Q
Sbjct: 91  ETWRPDSFYEKIQNNRRLGLHTLCLLDIRVKEPTLESLCRG-KKVYEPPRFMSVNTAISQ 149

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVE+  G S YG D+ C+G ARLGS+DQ IVAG MK+L  VDFG PLHCL+IVGETHP
Sbjct: 150 LLEVEELCGGSAYGADSLCIGVARLGSDDQKIVAGPMKKLLDVDFGPPLHCLIIVGETHP 209

Query: 362 VEEEMLEFYKYKS 400
           VEEEM+EF+  KS
Sbjct: 210 VEEEMIEFHMIKS 222

[7][TOP]
>UniRef100_C6TBK2 Diphthine synthase n=1 Tax=Glycine max RepID=C6TBK2_SOYBN
          Length = 278

 Score =  210 bits (535), Expect = 4e-53
 Identities = 101/133 (75%), Positives = 114/133 (85%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDSFYEKI++N S+GLHTLCLLDIRVKE T ESLCRG +K YEPPRYM++NTAIEQ
Sbjct: 143 ETWRPDSFYEKIQRNLSMGLHTLCLLDIRVKELTLESLCRG-RKAYEPPRYMTINTAIEQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+ Q   +  Y EDT+CVG ARLGSEDQ IVAGTMKQL+ VDFGAPLHCLVI G THP
Sbjct: 202 LLEIVQAREEPAYTEDTECVGLARLGSEDQMIVAGTMKQLQMVDFGAPLHCLVITGRTHP 261

Query: 362 VEEEMLEFYKYKS 400
           VEEEML FY+ ++
Sbjct: 262 VEEEMLYFYRCRT 274

[8][TOP]
>UniRef100_C5WZQ7 Diphthine synthase n=1 Tax=Sorghum bicolor RepID=C5WZQ7_SORBI
          Length = 273

 Score =  204 bits (519), Expect = 3e-51
 Identities = 98/132 (74%), Positives = 110/132 (83%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDSFYEKI+ NR LGLHTLCLLDIRVKEPT+ESL RG KK YEPPR+M+VNTAI Q
Sbjct: 143 DEWRPDSFYEKIQNNRKLGLHTLCLLDIRVKEPTWESLARG-KKVYEPPRFMTVNTAISQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           L EVE+  G S YG DT C+G ARLGS+DQ IVAG M++L  VDFG PLHCL+IVGETHP
Sbjct: 202 LFEVEEARGGSAYGRDTLCIGVARLGSDDQKIVAGPMEKLLDVDFGPPLHCLIIVGETHP 261

Query: 362 VEEEMLEFYKYK 397
           +EEEMLEFY  K
Sbjct: 262 LEEEMLEFYMIK 273

[9][TOP]
>UniRef100_B4F8L2 Diphthine synthase n=1 Tax=Zea mays RepID=B4F8L2_MAIZE
          Length = 273

 Score =  197 bits (501), Expect = 3e-49
 Identities = 95/132 (71%), Positives = 108/132 (81%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDSFYEKI+ NR LGLHTLCLLDIRVKEPT+ESL RG KK YEPPR+M+VNTAI Q
Sbjct: 143 DEWRPDSFYEKIQNNRQLGLHTLCLLDIRVKEPTWESLARG-KKVYEPPRFMTVNTAISQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           L EVE+  G   Y  +T C+G ARLGS+DQ IVAG M++L  VDFG PLHCL+IVGETHP
Sbjct: 202 LFEVEEARGGYAYRRETLCIGVARLGSDDQKIVAGPMEKLLDVDFGPPLHCLIIVGETHP 261

Query: 362 VEEEMLEFYKYK 397
           +EEEMLEFY  K
Sbjct: 262 LEEEMLEFYMIK 273

[10][TOP]
>UniRef100_A9TVZ2 Diphthine synthase n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9TVZ2_PHYPA
          Length = 273

 Score =  187 bits (474), Expect = 4e-46
 Identities = 89/130 (68%), Positives = 105/130 (80%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRPDSFY+KI+ NR +GLHTLCLLDIRVKE + E+LCRG +K+YEPPRYMS+NTAIEQ
Sbjct: 143 DTWRPDSFYDKIEANRKIGLHTLCLLDIRVKEQSVEALCRG-RKEYEPPRYMSINTAIEQ 201

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVE+     VY E+T CVG ARLG+  Q IVAG+MK+L  VDFG PLH +VI G TH 
Sbjct: 202 LLEVEETRAGKVYSEETLCVGLARLGTSTQKIVAGSMKELLDVDFGPPLHSVVIAGTTHV 261

Query: 362 VEEEMLEFYK 391
           +EEE L FYK
Sbjct: 262 MEEEFLSFYK 271

[11][TOP]
>UniRef100_A8JG68 Predicted protein (Fragment) n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8JG68_CHLRE
          Length = 179

 Score =  167 bits (424), Expect = 3e-40
 Identities = 81/130 (62%), Positives = 97/130 (74%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++WRPDSFY+KI  NR +GLHTLCLLDI+VKEP   +L RG +  YEPPRYMS+ TAIEQ
Sbjct: 51  DSWRPDSFYDKILANRKMGLHTLCLLDIKVKEPDLAALARG-RTVYEPPRYMSIKTAIEQ 109

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVE   G   YG D+  VG ARL ++DQ IVAGT+ QL  VDFG PLH LV+ GE H 
Sbjct: 110 LLEVEAARGGGAYGPDSLAVGIARLQADDQQIVAGTLAQLLEVDFGLPLHSLVLAGEVHV 169

Query: 362 VEEEMLEFYK 391
            E+EML+ Y+
Sbjct: 170 TEQEMLQHYR 179

[12][TOP]
>UniRef100_C1EI41 Diphthine synthase n=1 Tax=Micromonas sp. RCC299 RepID=C1EI41_9CHLO
          Length = 286

 Score =  167 bits (423), Expect = 3e-40
 Identities = 76/131 (58%), Positives = 101/131 (77%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           TWRPDSFY++IK+N  LGLHTL LLDIRVKEP+ E+LCRG KK+YEPPR+MS  T   Q+
Sbjct: 139 TWRPDSFYDRIKENADLGLHTLLLLDIRVKEPSVEALCRG-KKEYEPPRFMSCATCARQM 197

Query: 185 LEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPV 364
           LEVE   G+ VYG D+ CV  AR+G +D+ I + T+K++ ++D G PLH +V+VGETHP+
Sbjct: 198 LEVEDARGEKVYGPDSMCVAVARMGQDDELIKSCTLKEMCNIDMGGPLHSMVLVGETHPL 257

Query: 365 EEEMLEFYKYK 397
           E +ML  ++ K
Sbjct: 258 ENDMLAMHRAK 268

[13][TOP]
>UniRef100_C1N643 Diphthine synthase n=1 Tax=Micromonas pusilla CCMP1545
           RepID=C1N643_9CHLO
          Length = 286

 Score =  166 bits (420), Expect = 8e-40
 Identities = 75/132 (56%), Positives = 104/132 (78%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRPDSFY++IK+N +LGLHTL LLDIRVKEP+ E+LCRG K +YEPPR+MS  T   Q
Sbjct: 138 QTWRPDSFYDRIKENAALGLHTLLLLDIRVKEPSVEALCRG-KNEYEPPRFMSCATCARQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           L+EVE+  G+ VYG D+ CV  AR+G +D+ I + T+K++ +VD G PLH +V+VG+THP
Sbjct: 197 LMEVEELRGEGVYGPDSMCVAVARMGQDDEVIKSCTLKEMCNVDVGGPLHSMVLVGDTHP 256

Query: 362 VEEEMLEFYKYK 397
           +E++ML  ++ K
Sbjct: 257 LEDDMLLMHRAK 268

[14][TOP]
>UniRef100_A9V6F4 Diphthine synthase n=1 Tax=Monosiga brevicollis RepID=A9V6F4_MONBE
          Length = 369

 Score =  160 bits (406), Expect = 3e-38
 Identities = 75/130 (57%), Positives = 100/130 (76%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRPDSFY K+K N+ +GLHTLCL+DI+VKE + E+L +G +K +EPPRYM+VN   +Q
Sbjct: 221 EQWRPDSFYAKMKANKDMGLHTLCLVDIKVKEQSIENLIKG-RKIFEPPRYMTVNQCAKQ 279

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLEVE+K+G+ V G D+  VG AR+G  DQ IV GT+ +L +VDFG PLH LV++GET  
Sbjct: 280 LLEVEEKYGEGVCGPDSLAVGVARVGCTDQRIVFGTLSELVTVDFGPPLHSLVVIGETDE 339

Query: 362 VEEEMLEFYK 391
           +E E+L+ YK
Sbjct: 340 IEREVLDMYK 349

[15][TOP]
>UniRef100_Q5U3P6 Diphthine synthase n=1 Tax=Danio rerio RepID=Q5U3P6_DANRE
          Length = 288

 Score =  158 bits (400), Expect = 2e-37
 Identities = 78/133 (58%), Positives = 99/133 (74%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SFY+KIKKNR +GLHTLCLLDI+VKE + E+L R G+K YEPPRYM+V  A EQ
Sbjct: 138 DTWRPESFYDKIKKNRDMGLHTLCLLDIKVKEQSMENLVR-GRKIYEPPRYMTVAQAAEQ 196

Query: 182 LLEVEQKHGDS----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ Q   D        EDT CVG AR+G+EDQTI +GT+++L S D G PLH L+I G
Sbjct: 197 LLEILQNRRDRGEELAMTEDTVCVGLARVGAEDQTIRSGTLRELASCDLGGPLHSLIISG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E +ML+ +
Sbjct: 257 HLHPLEVDMLKLF 269

[16][TOP]
>UniRef100_Q1LVV5 Diphthine synthase n=1 Tax=Danio rerio RepID=Q1LVV5_DANRE
          Length = 288

 Score =  158 bits (400), Expect = 2e-37
 Identities = 78/133 (58%), Positives = 99/133 (74%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SFY+KIKKNR +GLHTLCLLDI+VKE + E+L R G+K YEPPRYM+V  A EQ
Sbjct: 138 DTWRPESFYDKIKKNRDMGLHTLCLLDIKVKEQSMENLMR-GRKIYEPPRYMTVAQAAEQ 196

Query: 182 LLEVEQKHGDS----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ Q   D        EDT CVG AR+G+EDQTI +GT+++L S D G PLH L+I G
Sbjct: 197 LLEILQNRRDRGEELAVTEDTVCVGLARVGAEDQTIRSGTLRELASCDLGGPLHSLIISG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E +ML+ +
Sbjct: 257 HLHPLEVDMLKLF 269

[17][TOP]
>UniRef100_Q75JG8 Diphthine synthase n=1 Tax=Dictyostelium discoideum
           RepID=DPH5_DICDI
          Length = 273

 Score =  157 bits (396), Expect = 5e-37
 Identities = 71/132 (53%), Positives = 101/132 (76%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ET +PDS+Y+++K NR  G+HTLCLLDI+VKE + E++CRG +  YEPPR+M+VN  IEQ
Sbjct: 141 ETTKPDSWYDRVKINRVNGMHTLCLLDIKVKEQSIENMCRG-RLIYEPPRFMTVNQCIEQ 199

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+E+   + VY +DT C+G +R+G +DQ I++GTMK+L  VDFGAPLH  +I G+ H 
Sbjct: 200 LLEIEEIRKEKVYDQDTLCIGLSRVGQDDQQIISGTMKELLDVDFGAPLHSFIICGDMHF 259

Query: 362 VEEEMLEFYKYK 397
           +E+E  E ++ K
Sbjct: 260 IEKEYFETFRVK 271

[18][TOP]
>UniRef100_A5PMX3 Diphthine synthase n=1 Tax=Danio rerio RepID=A5PMX3_DANRE
          Length = 288

 Score =  155 bits (392), Expect = 1e-36
 Identities = 77/133 (57%), Positives = 98/133 (73%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SFY+KIKKNR +GLHTLCLLDI+VKE + E+L R G+K YEPPRYM+V  A EQ
Sbjct: 138 DTWRPESFYDKIKKNRDMGLHTLCLLDIKVKEQSMENLMR-GRKIYEPPRYMTVAQAAEQ 196

Query: 182 LLEVEQKHGDS----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ Q   D        EDT CVG AR+G+EDQTI +GT+++L S D   PLH L+I G
Sbjct: 197 LLEILQNRRDRGEELAMTEDTVCVGLARVGAEDQTIRSGTLRELASCDLEGPLHSLIISG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E +ML+ +
Sbjct: 257 HLHPLEVDMLKLF 269

[19][TOP]
>UniRef100_A4S8B3 Diphthine synthase n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4S8B3_OSTLU
          Length = 284

 Score =  153 bits (386), Expect = 7e-36
 Identities = 72/132 (54%), Positives = 95/132 (71%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRPDSFY+ I+ NR  G HTLCLLDIRVKEPT  +LC+G  ++YEP R+M+  TA +Q
Sbjct: 138 QTWRPDSFYDLIRDNRKSGAHTLCLLDIRVKEPTVRALCKG-IEEYEPARFMTAATAAKQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           +LEVE+  G+ VYGEDT CV  AR+G +D+ I A T+ ++  VD GAPLH LV+VG+   
Sbjct: 197 MLEVEESRGEGVYGEDTMCVAVARIGQDDEKIRACTLGEMRRVDMGAPLHSLVLVGDVME 256

Query: 362 VEEEMLEFYKYK 397
           +E  ML  +  K
Sbjct: 257 IESAMLATHAVK 268

[20][TOP]
>UniRef100_Q23A33 Diphthine synthase n=1 Tax=Tetrahymena thermophila SB210
           RepID=Q23A33_TETTH
          Length = 279

 Score =  152 bits (385), Expect = 9e-36
 Identities = 75/134 (55%), Positives = 95/134 (70%), Gaps = 1/134 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRP SFYEKIKKNR +GLHTLCLLDI+VKE T E++ +G KK YEPPR+MS  TA+EQ
Sbjct: 142 EKWRPYSFYEKIKKNREMGLHTLCLLDIKVKERTDENILKG-KKIYEPPRFMSCKTAVEQ 200

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-VGETH 358
           LLE E+K     + ++T+CVG AR+G  DQ I +G M    +++ G PLH  VI   E H
Sbjct: 201 LLEAEEKIAGKAFSKETKCVGVARVGFSDQLIRSGQMSDFLNIEMGPPLHSFVICADELH 260

Query: 359 PVEEEMLEFYKYKS 400
           P+EE+M +FY   S
Sbjct: 261 PIEEDMYKFYNQNS 274

[21][TOP]
>UniRef100_UPI000155CAC8 PREDICTED: similar to very large inducible GTPase 1 n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155CAC8
          Length = 275

 Score =  152 bits (383), Expect = 1e-35
 Identities = 75/133 (56%), Positives = 99/133 (74%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P+SF++KIKKNR  GLHTLCLLDI+VKE + E+L +G KK YEPPR+MSVN A  Q
Sbjct: 138 DTWKPESFFDKIKKNRLSGLHTLCLLDIKVKEQSLENLMKG-KKIYEPPRFMSVNQAAGQ 196

Query: 182 LLEVEQKHG----DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           +LEV Q       +    E+T CVG AR+G++DQ IVAGT++QL +VD G PLH L+I G
Sbjct: 197 ILEVVQNRRLLGEEPGISEETMCVGLARVGADDQKIVAGTLQQLCTVDLGGPLHSLIITG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E +ML+ +
Sbjct: 257 TMHPLEVDMLKIF 269

[22][TOP]
>UniRef100_A8JZY6 Diphthine synthase n=1 Tax=Homo sapiens RepID=A8JZY6_HUMAN
          Length = 284

 Score =  151 bits (382), Expect = 2e-35
 Identities = 74/133 (55%), Positives = 99/133 (74%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQK---HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-G 349
           LLE+ Q     G+    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  G
Sbjct: 197 LLEIVQNQRIRGEEPVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E EML  +
Sbjct: 257 SIHPMEMEMLSLF 269

[23][TOP]
>UniRef100_Q569A7 Diphthine synthase n=1 Tax=Rattus norvegicus RepID=Q569A7_RAT
          Length = 281

 Score =  151 bits (381), Expect = 3e-35
 Identities = 77/134 (57%), Positives = 100/134 (74%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L R G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRENGMHTLCLLDIKVKEQSLENLIR-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQKH---GDS-VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q H   G++    E+T CVG AR+G+EDQ I AGT++Q+ +V  G PLH LVI  
Sbjct: 197 LLEIVQNHRARGEAPAITEETLCVGLARVGAEDQKIAAGTLQQMCTVSLGEPLHSLVITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GNLHPLEMEMLSLF 270

[24][TOP]
>UniRef100_Q5E982 Diphthine synthase n=1 Tax=Bos taurus RepID=DPH5_BOVIN
          Length = 285

 Score =  151 bits (381), Expect = 3e-35
 Identities = 74/134 (55%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G+EDQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 197 LLEIVQNQRIRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQMSTVDLGGPLHSLIITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GSLHPLEMEMLSLF 270

[25][TOP]
>UniRef100_Q6PAC5 Diphthine synthase n=1 Tax=Mus musculus RepID=Q6PAC5_MOUSE
          Length = 281

 Score =  150 bits (380), Expect = 3e-35
 Identities = 75/134 (55%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+K+NR+ G+HTLCLLDI+VKE + E+L R G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKRNRANGMHTLCLLDIKVKEQSLENLIR-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQKH----GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q H     +    E+T CVG AR+G+EDQ I AGT++Q+ +V  G PLH LVI  
Sbjct: 197 LLEIVQNHRARGEEPAITEETLCVGLARVGAEDQKIAAGTLQQMCTVSLGEPLHSLVITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GNLHPLEMEMLSLF 270

[26][TOP]
>UniRef100_Q9CWQ0 Diphthine synthase n=1 Tax=Mus musculus RepID=DPH5_MOUSE
          Length = 281

 Score =  150 bits (380), Expect = 3e-35
 Identities = 75/134 (55%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+K+NR+ G+HTLCLLDI+VKE + E+L R G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKRNRANGMHTLCLLDIKVKEQSLENLIR-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQKH----GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q H     +    E+T CVG AR+G+EDQ I AGT++Q+ +V  G PLH LVI  
Sbjct: 197 LLEIVQNHRARGEEPAITEETLCVGLARVGAEDQKIAAGTLQQMCTVSLGEPLHSLVITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GNLHPLEMEMLSLF 270

[27][TOP]
>UniRef100_UPI00005A1271 PREDICTED: similar to Probable diphthine synthase (Diphthamide
           biosynthesis methyltransferase) n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1271
          Length = 292

 Score =  150 bits (379), Expect = 4e-35
 Identities = 72/134 (53%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI++KE + E+L + G+K YEPPRYMS+N A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKIKEQSLENLIK-GRKIYEPPRYMSINQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ Q    +  +    E T CVG AR+G+EDQ I AGT++Q+ +VD G PLH L+I G
Sbjct: 197 LLEIVQNQRMRGEEPAVTEKTLCVGLARVGAEDQKIAAGTLQQMSTVDLGGPLHSLIITG 256

Query: 350 ET-HPVEEEMLEFY 388
           +  HP+E EML  +
Sbjct: 257 DNMHPLEMEMLSLF 270

[28][TOP]
>UniRef100_UPI0000EB3383 Probable diphthine synthase (EC 2.1.1.98) (Diphthamide biosynthesis
           methyltransferase). n=1 Tax=Canis lupus familiaris
           RepID=UPI0000EB3383
          Length = 280

 Score =  150 bits (379), Expect = 4e-35
 Identities = 72/134 (53%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI++KE + E+L + G+K YEPPRYMS+N A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKIKEQSLENLIK-GRKIYEPPRYMSINQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ Q    +  +    E T CVG AR+G+EDQ I AGT++Q+ +VD G PLH L+I G
Sbjct: 197 LLEIVQNQRMRGEEPAVTEKTLCVGLARVGAEDQKIAAGTLQQMSTVDLGGPLHSLIITG 256

Query: 350 ET-HPVEEEMLEFY 388
           +  HP+E EML  +
Sbjct: 257 DNMHPLEMEMLSLF 270

[29][TOP]
>UniRef100_Q4Q6A1 Diphthine synthase n=1 Tax=Leishmania major RepID=Q4Q6A1_LEIMA
          Length = 271

 Score =  150 bits (378), Expect = 6e-35
 Identities = 77/132 (58%), Positives = 100/132 (75%), Gaps = 2/132 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDS+YE+++ NR+ G+HTL LLDI+VKE + E+L RG +K YEPPRYM++  AIEQ
Sbjct: 137 ETWRPDSWYERLQSNRAAGIHTLVLLDIKVKEISDENLARG-RKIYEPPRYMTIRQAIEQ 195

Query: 182 LLEVE-QKHGDSVYGE-DTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET 355
           +LEVE  K G +V  +  T  VG AR+GSE Q +VAGTMK L SVDFGAPLH LVI G+ 
Sbjct: 196 ILEVEGYKQGGAVAADGSTFAVGLARVGSESQQVVAGTMKDLLSVDFGAPLHSLVIAGDV 255

Query: 356 HPVEEEMLEFYK 391
           H  E+E ++ ++
Sbjct: 256 HDCEQEHVDLFR 267

[30][TOP]
>UniRef100_A4I6T9 Diphthine synthase n=1 Tax=Leishmania infantum RepID=A4I6T9_LEIIN
          Length = 271

 Score =  150 bits (378), Expect = 6e-35
 Identities = 76/132 (57%), Positives = 100/132 (75%), Gaps = 2/132 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDS+YE+++ NR+ G+HTL LLDI+VKE + E+L RG +K YEPPRYM++  A+EQ
Sbjct: 137 ETWRPDSWYERLRSNRAAGIHTLVLLDIKVKEISDENLARG-RKIYEPPRYMTIRQAVEQ 195

Query: 182 LLEVE-QKHGDSVYGE-DTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET 355
           +LEVE  K G +V  +  T  VG AR+GSE Q +VAGTMK L SVDFGAPLH LVI G+ 
Sbjct: 196 ILEVEGYKQGGAVAADGSTFAVGLARVGSESQQVVAGTMKDLLSVDFGAPLHSLVIAGDV 255

Query: 356 HPVEEEMLEFYK 391
           H  E+E ++ ++
Sbjct: 256 HDCEQEHVDLFR 267

[31][TOP]
>UniRef100_UPI000155E318 PREDICTED: similar to diphthine synthase n=1 Tax=Equus caballus
           RepID=UPI000155E318
          Length = 285

 Score =  149 bits (377), Expect = 7e-35
 Identities = 74/134 (55%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G+EDQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 197 LLEIVQNQRIRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQMCTVDLGGPLHSLIITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GSMHPLEMEMLSLF 270

[32][TOP]
>UniRef100_UPI00017EFAF8 PREDICTED: similar to CGI-30 protein n=1 Tax=Sus scrofa
           RepID=UPI00017EFAF8
          Length = 285

 Score =  149 bits (375), Expect = 1e-34
 Identities = 74/134 (55%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRLNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G+EDQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 197 LLEIVQNQRMRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQMCTVDLGGPLHSLIITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GSLHPLEMEMLRLF 270

[33][TOP]
>UniRef100_C4JYE1 Diphthine synthase n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JYE1_UNCRE
          Length = 172

 Score =  149 bits (375), Expect = 1e-34
 Identities = 67/130 (51%), Positives = 97/130 (74%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY++IK+N  +GLHTL LLDI+VKE + E++ RG KK YEPPRYM+V     Q
Sbjct: 25  ETWKPSSFYDRIKENAQIGLHTLVLLDIKVKEQSLENMARG-KKIYEPPRYMTVAQCASQ 83

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-TH 358
           +LE+E++  ++VYG D+  +G AR+G+EDQ +  GT+KQL  +D G PLHCL+++G+ TH
Sbjct: 84  MLEIEEQRKEAVYGPDSLAIGAARVGAEDQKLAVGTLKQLTEIDMGEPLHCLILLGKRTH 143

Query: 359 PVEEEMLEFY 388
            +E + +  Y
Sbjct: 144 DLERDFIRDY 153

[34][TOP]
>UniRef100_UPI0000D99A5F PREDICTED: DPH5 homolog (S. cerevisiae) isoform 2 n=1 Tax=Macaca
           mulatta RepID=UPI0000D99A5F
          Length = 234

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 87  DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 145

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 146 LLEIIQNQRIRGEEPAITEETLCVGLARVGADDQKIAAGTLQQMCTVDLGEPLHSLIITG 205

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 206 GSIHPIEMEMLNLF 219

[35][TOP]
>UniRef100_UPI0000D99A5E PREDICTED: DPH5 homolog isoform 5 n=1 Tax=Macaca mulatta
           RepID=UPI0000D99A5E
          Length = 285

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 197 LLEIIQNQRIRGEEPAITEETLCVGLARVGADDQKIAAGTLQQMCTVDLGEPLHSLIITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GSIHPIEMEMLNLF 270

[36][TOP]
>UniRef100_UPI0001AE7911 Probable diphthine synthase (EC 2.1.1.98) (Diphthamide biosynthesis
           methyltransferase). n=1 Tax=Homo sapiens
           RepID=UPI0001AE7911
          Length = 297

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 150 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 208

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 209 LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 268

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 269 GSIHPMEMEMLSLF 282

[37][TOP]
>UniRef100_UPI00015E0BE1 UPI00015E0BE1 related cluster n=1 Tax=Homo sapiens
           RepID=UPI00015E0BE1
          Length = 234

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 87  DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 145

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 146 LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 205

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 206 GSIHPMEMEMLSLF 219

[38][TOP]
>UniRef100_Q6DEZ3 Diphthine synthase n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=Q6DEZ3_XENTR
          Length = 290

 Score =  148 bits (374), Expect = 2e-34
 Identities = 72/133 (54%), Positives = 98/133 (73%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P+SFY+KI++NR  G+HTLCLLDI+VKE + E+L +G K  +EPPRYM+VN A++Q
Sbjct: 138 DTWKPESFYDKIRRNRLSGMHTLCLLDIKVKEQSIENLMKGNKA-FEPPRYMTVNQAVDQ 196

Query: 182 LLEVEQKHGDS----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ Q   +        E+T C G AR+G+ DQ I AGT++QL SVDFG PLH LVI G
Sbjct: 197 LLEIVQNRRELGEELALTENTICAGLARVGASDQKISAGTLQQLSSVDFGGPLHSLVISG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E +ML+ +
Sbjct: 257 CMHPLELDMLKLF 269

[39][TOP]
>UniRef100_B3KWP1 cDNA FLJ43496 fis, clone PEBLM2001465, highly similar to Probable
           diphthine synthase (EC 2.1.1.98) n=1 Tax=Homo sapiens
           RepID=B3KWP1_HUMAN
          Length = 172

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 25  DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 83

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 84  LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 143

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 144 GSIHPMEMEMLSLF 157

[40][TOP]
>UniRef100_Q9H2P9-5 Isoform 5 of Diphthine synthase n=1 Tax=Homo sapiens RepID=Q9H2P9-5
          Length = 297

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 150 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 208

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 209 LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 268

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 269 GSIHPMEMEMLSLF 282

[41][TOP]
>UniRef100_Q9H2P9-2 Isoform 2 of Diphthine synthase n=1 Tax=Homo sapiens RepID=Q9H2P9-2
          Length = 234

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 87  DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 145

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 146 LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 205

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 206 GSIHPMEMEMLSLF 219

[42][TOP]
>UniRef100_Q9H2P9 Diphthine synthase n=1 Tax=Homo sapiens RepID=DPH5_HUMAN
          Length = 285

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/134 (54%), Positives = 99/134 (73%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 196

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 197 LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 257 GSIHPMEMEMLSLF 270

[43][TOP]
>UniRef100_A7RTU2 Diphthine synthase n=1 Tax=Nematostella vectensis
           RepID=A7RTU2_NEMVE
          Length = 279

 Score =  147 bits (372), Expect = 3e-34
 Identities = 74/131 (56%), Positives = 95/131 (72%), Gaps = 4/131 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E+W+PDSFY+KI  NR  GLH+LCLLDI+VKE + E+L RG +K YEPPRYMSV+TA++Q
Sbjct: 138 ESWKPDSFYDKIAANRKRGLHSLCLLDIKVKEQSVENLMRG-RKVYEPPRYMSVSTAVQQ 196

Query: 182 LLEVEQKHG----DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+ +       +S Y EDT  VG AR+GS+ Q I+ G MK L   D G PLH LVI G
Sbjct: 197 LLEIPKLRNLSPQESAYTEDTVAVGLARIGSDTQQIICGPMKSLVDYDLGGPLHSLVIPG 256

Query: 350 ETHPVEEEMLE 382
           E H +E++ML+
Sbjct: 257 EMHFLEKDMLK 267

[44][TOP]
>UniRef100_B8BQN6 Diphthine synthase n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B8BQN6_THAPS
          Length = 289

 Score =  147 bits (371), Expect = 4e-34
 Identities = 75/133 (56%), Positives = 94/133 (70%), Gaps = 1/133 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRP SFY KIK NR  G+HTLCLLDI+VKEP FE++ RG K  Y PPR+M V+ A EQ
Sbjct: 140 ENWRPTSFYPKIKYNRLGGMHTLCLLDIKVKEPDFEAMKRG-KIVYLPPRFMPVDVASEQ 198

Query: 182 LLEVEQ-KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETH 358
           L+E E+ + G +   E T CVG ARLG  DQ I+AGT+++L++ D GAPLHC++I GE H
Sbjct: 199 LIEAEETRKGGAYKPESTLCVGLARLGQPDQCIMAGTLEELKNADLGAPLHCMIICGEVH 258

Query: 359 PVEEEMLEFYKYK 397
            +E E L  Y  K
Sbjct: 259 DMELEALRPYLIK 271

[45][TOP]
>UniRef100_UPI0000E48550 PREDICTED: similar to DPH5 homolog n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E48550
          Length = 285

 Score =  146 bits (369), Expect = 6e-34
 Identities = 73/132 (55%), Positives = 99/132 (75%), Gaps = 5/132 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+PDS+Y+KI  NRS GLHTLCLLDI++KE + E+L +G +K +EPPR+++V  A  Q
Sbjct: 138 DTWKPDSYYDKIASNRSRGLHTLCLLDIKMKEQSVENLIKG-RKIFEPPRFLTVPQAASQ 196

Query: 182 LLEV---EQKHGD--SVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV 346
           LLE+    ++ GD  + Y EDT C+G AR+GS+ Q IV+GT+++L SVD G PLH LVI 
Sbjct: 197 LLEIPDRRKERGDDYTAYTEDTICIGVARVGSDTQRIVSGTLRELTSVDLGDPLHSLVIA 256

Query: 347 GETHPVEEEMLE 382
           G  HPVE EML+
Sbjct: 257 GHMHPVELEMLK 268

[46][TOP]
>UniRef100_UPI0000E46366 PREDICTED: similar to DPH5 homolog n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E46366
          Length = 285

 Score =  146 bits (369), Expect = 6e-34
 Identities = 73/132 (55%), Positives = 99/132 (75%), Gaps = 5/132 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+PDS+Y+KI  NRS GLHTLCLLDI++KE + E+L +G +K +EPPR+++V  A  Q
Sbjct: 138 DTWKPDSYYDKIASNRSRGLHTLCLLDIKMKEQSVENLIKG-RKIFEPPRFLTVPQAASQ 196

Query: 182 LLEV---EQKHGD--SVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV 346
           LLE+    ++ GD  + Y EDT C+G AR+GS+ Q IV+GT+++L SVD G PLH LVI 
Sbjct: 197 LLEIPDRRKERGDDYTAYTEDTICIGVARVGSDTQQIVSGTLRELTSVDLGDPLHSLVIA 256

Query: 347 GETHPVEEEMLE 382
           G  HPVE EML+
Sbjct: 257 GHMHPVELEMLK 268

[47][TOP]
>UniRef100_UPI000194CDE5 PREDICTED: similar to GekBS016P n=1 Tax=Taeniopygia guttata
           RepID=UPI000194CDE5
          Length = 285

 Score =  146 bits (368), Expect = 8e-34
 Identities = 72/137 (52%), Positives = 101/137 (73%), Gaps = 4/137 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P+SF++KI+KNR  G+HTLCLLDI+VKE + E+L +G +K YEPPRYMSVN A EQ
Sbjct: 138 DTWKPESFFDKIEKNRQNGMHTLCLLDIKVKEQSLENLIKG-RKIYEPPRYMSVNQAAEQ 196

Query: 182 LLEVEQKH---GDSV-YGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LL + QK    G+     E+T CVG AR+G+ D+ I +GT++Q+ +V+ GAPLH L++ G
Sbjct: 197 LLAIIQKRRLQGEKPEITENTICVGLARVGALDEKIASGTLQQMSTVELGAPLHSLIVTG 256

Query: 350 ETHPVEEEMLEFYKYKS 400
             HP+E EML+ +   S
Sbjct: 257 TMHPLELEMLKLFSVDS 273

[48][TOP]
>UniRef100_C9ZMB0 Diphthine synthase, putative n=2 Tax=Trypanosoma brucei
           RepID=C9ZMB0_TRYBG
          Length = 269

 Score =  145 bits (366), Expect = 1e-33
 Identities = 73/131 (55%), Positives = 93/131 (70%), Gaps = 2/131 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDS+Y+++K NR  GLHTL LLDI+VKE + E+L RG +K YEPPRYM ++ AI+Q
Sbjct: 137 ETWKPDSWYDRLKTNRDAGLHTLVLLDIKVKEISDENLARG-RKVYEPPRYMKISEAIDQ 195

Query: 182 LLEVEQKHGDSVYGED--TQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET 355
           +L VE++ G      D  T  VG AR+GS  Q +VAG M+ L +VDFG PLH LVI GE 
Sbjct: 196 ILAVEKRKGRGAVAVDGGTLAVGMARVGSATQQVVAGPMQALRAVDFGTPLHSLVIAGEV 255

Query: 356 HPVEEEMLEFY 388
           HP EEE L  +
Sbjct: 256 HPCEEEHLRLF 266

[49][TOP]
>UniRef100_B7FSV8 Diphthine synthase (Fragment) n=1 Tax=Phaeodactylum tricornutum
           CCAP 1055/1 RepID=B7FSV8_PHATR
          Length = 271

 Score =  145 bits (365), Expect = 2e-33
 Identities = 70/130 (53%), Positives = 93/130 (71%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRP SFY KIK NR  G+HTLCLLDI+VKEP F+++ + GK +Y PP +MSVNTA EQ
Sbjct: 140 EKWRPTSFYPKIKINRQGGMHTLCLLDIKVKEPDFQAMMK-GKTKYLPPSFMSVNTASEQ 198

Query: 182 LLEVEQKHGDSVY-GEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETH 358
           LLE E  H +  Y G  T C+G AR+G + Q I AGT+++L++ + G PLH L+I G+ H
Sbjct: 199 LLEAEDSHKEHAYDGSQTLCIGLARMGQDSQCIRAGTLEELKNANMGEPLHSLIICGDLH 258

Query: 359 PVEEEMLEFY 388
            +E E+L+ Y
Sbjct: 259 DLEMEVLKEY 268

[50][TOP]
>UniRef100_A4HJE1 Diphthine synthase n=1 Tax=Leishmania braziliensis
           RepID=A4HJE1_LEIBR
          Length = 271

 Score =  145 bits (365), Expect = 2e-33
 Identities = 76/131 (58%), Positives = 96/131 (73%), Gaps = 2/131 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDS+YE+++ NR+ G+HTL LLDI+VKE + E+L R G+K YEPPRYMS+  A+EQ
Sbjct: 137 ETWRPDSWYERLRSNRAAGIHTLVLLDIKVKEISDENLAR-GRKIYEPPRYMSIKQAVEQ 195

Query: 182 LLEVE-QKHGDSVYGE-DTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET 355
           +LEVE  K G +V  +  T  VG AR+GS  Q +VAGTMK L SVDFGAPLH LVI G+ 
Sbjct: 196 ILEVEGYKQGGAVAADGSTFAVGVARVGSASQQVVAGTMKDLLSVDFGAPLHSLVIAGDV 255

Query: 356 HPVEEEMLEFY 388
           H  E E +  +
Sbjct: 256 HECELEHVNLF 266

[51][TOP]
>UniRef100_B6KHK1 Diphthine synthase n=3 Tax=Toxoplasma gondii RepID=B6KHK1_TOXGO
          Length = 275

 Score =  144 bits (364), Expect = 2e-33
 Identities = 73/134 (54%), Positives = 92/134 (68%), Gaps = 1/134 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E+WRPDSFY KIKKN+  G HTLCLLDI+ KE + E++ RG ++ YEPPR+MSV  A+ Q
Sbjct: 139 ESWRPDSFYMKIKKNKEAGFHTLCLLDIKTKEQSVENMMRG-RQIYEPPRFMSVEAAVRQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET-H 358
           LLEVE K G  V   D +  G AR+G+  Q I +GT+++L SVDFG PLH LVI   T H
Sbjct: 198 LLEVEDKLGGKVCPRDAKAFGLARIGAPSQQITSGTLEELLSVDFGPPLHSLVICAPTLH 257

Query: 359 PVEEEMLEFYKYKS 400
            +E E  E +  KS
Sbjct: 258 EMEREFFELFSGKS 271

[52][TOP]
>UniRef100_C5PAB0 Diphthine synthase n=2 Tax=Coccidioides RepID=C5PAB0_COCP7
          Length = 285

 Score =  144 bits (362), Expect = 4e-33
 Identities = 65/130 (50%), Positives = 95/130 (73%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY++IK+N  +GLHTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSFYDRIKENIQIGLHTLVLLDIKVKEQSLENMARG-RKVYEPPRYMTVAQCAGQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-TH 358
           +LE+E++  + VYG D+  +G AR+G+EDQ +  GT+K+L   D G PLHCL+++G+ TH
Sbjct: 197 MLEIEEERKEGVYGPDSLAIGAARVGAEDQKLAVGTLKELTETDMGEPLHCLILLGKRTH 256

Query: 359 PVEEEMLEFY 388
            +E + +  Y
Sbjct: 257 DLERDFIREY 266

[53][TOP]
>UniRef100_Q4CSY4 Diphthine synthase n=1 Tax=Trypanosoma cruzi RepID=Q4CSY4_TRYCR
          Length = 269

 Score =  143 bits (360), Expect = 7e-33
 Identities = 70/134 (52%), Positives = 93/134 (69%), Gaps = 2/134 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDS+Y+++  NR +GLHTL LLDI+VKE + E+L R G+  YEPPRYM +N AI+Q
Sbjct: 137 ETWRPDSWYDRLMSNREMGLHTLVLLDIKVKEISDENLAR-GRNVYEPPRYMRINEAIDQ 195

Query: 182 LLEVEQKHGDSVYGED--TQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET 355
           +LEVEQK       ED  T  +  AR+GS  Q +VAGTM++L  +DFG PLH L+I G+ 
Sbjct: 196 ILEVEQKKKGGAVAEDGSTMSIALARVGSNAQQVVAGTMRELRELDFGDPLHSLIIAGDI 255

Query: 356 HPVEEEMLEFYKYK 397
           H  E E +  ++ K
Sbjct: 256 HTCETEHVNLFRSK 269

[54][TOP]
>UniRef100_Q4DIT8 Diphthine synthase n=1 Tax=Trypanosoma cruzi RepID=Q4DIT8_TRYCR
          Length = 334

 Score =  142 bits (358), Expect = 1e-32
 Identities = 70/134 (52%), Positives = 91/134 (67%), Gaps = 2/134 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW PDS+Y+++  NR +GLHTL LLDIRVKE + E+L R G+  YEPPRYM +N AIEQ
Sbjct: 202 ETWHPDSWYDRLMSNREMGLHTLVLLDIRVKEISDENLAR-GRNVYEPPRYMRINEAIEQ 260

Query: 182 LLEVEQKHGDSVYGED--TQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET 355
           +LEVEQK       ED  T  +  AR+GS  Q +VAG M++L  +DFG PLH L+I G+ 
Sbjct: 261 ILEVEQKKKGGAVAEDGSTMSIALARVGSNTQQVVAGAMRELRGLDFGDPLHSLIIAGDI 320

Query: 356 HPVEEEMLEFYKYK 397
           H  E E +  ++ K
Sbjct: 321 HTCETEHVNLFRLK 334

[55][TOP]
>UniRef100_UPI00018683E9 hypothetical protein BRAFLDRAFT_286354 n=1 Tax=Branchiostoma
           floridae RepID=UPI00018683E9
          Length = 285

 Score =  140 bits (354), Expect = 3e-32
 Identities = 71/134 (52%), Positives = 89/134 (66%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+PDS+Y+KI  NR  G HTLCLLDI+VKE + E+L +G +K YEPPRYMSV  A EQ
Sbjct: 138 DDWKPDSYYDKIAANREKGWHTLCLLDIKVKEQSIENLMKG-RKIYEPPRYMSVKQAAEQ 196

Query: 182 LLEVEQKHGDS-----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV 346
            LE+ QK  +         EDT CVG AR+G++ Q I AGT+ QL   D G PLH LVI 
Sbjct: 197 FLEIVQKKREQEAEKLAIEEDTICVGLARIGTDTQQIAAGTLTQLAETDMGGPLHSLVIP 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E +ML  +
Sbjct: 257 GHMHPLEIDMLRHF 270

[56][TOP]
>UniRef100_UPI0001AE7912 UPI0001AE7912 related cluster n=1 Tax=Homo sapiens
           RepID=UPI0001AE7912
          Length = 284

 Score =  140 bits (354), Expect = 3e-32
 Identities = 71/134 (52%), Positives = 97/134 (72%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +T  P+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +Q
Sbjct: 137 QTLGPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQ 195

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV- 346
           LLE+ Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  
Sbjct: 196 LLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITG 255

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E EML  +
Sbjct: 256 GSIHPMEMEMLSLF 269

[57][TOP]
>UniRef100_Q6CIZ1 Diphthine synthase n=1 Tax=Kluyveromyces lactis RepID=DPH5_KLULA
          Length = 298

 Score =  140 bits (354), Expect = 3e-32
 Identities = 72/130 (55%), Positives = 93/130 (71%), Gaps = 2/130 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++WRPDS+Y+KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYMS+    EQ
Sbjct: 139 DSWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARG-RLIYEPPRYMSIAQCCEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+  G   Y  DT CV  +RLGS  QT  AGT+K+L   D G PLH LVI+G +TH
Sbjct: 198 LLEIEETRGTEAYTPDTPCVAISRLGSASQTFKAGTIKELAEYDSGEPLHSLVILGRQTH 257

Query: 359 PVE-EEMLEF 385
            +E E +LEF
Sbjct: 258 ELEIEYLLEF 267

[58][TOP]
>UniRef100_UPI000065FF6B UPI000065FF6B related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI000065FF6B
          Length = 288

 Score =  140 bits (353), Expect = 4e-32
 Identities = 70/131 (53%), Positives = 97/131 (74%), Gaps = 4/131 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SFY++I KNR  G HTLCLLDI+VKE + E++ RG KK YEPPR+M+V  A +Q
Sbjct: 138 DTWRPESFYDRICKNREAGQHTLCLLDIKVKEQSEENMMRG-KKIYEPPRFMTVAQAADQ 196

Query: 182 LLEVEQKH---GDSV-YGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           L+++ Q+    G+++   EDT CVG ARLG++DQ +   T++QL S D G PLH LVI G
Sbjct: 197 LVQIVQRRRAEGETLGLTEDTLCVGLARLGADDQVMRVATLQQLVSCDLGGPLHSLVITG 256

Query: 350 ETHPVEEEMLE 382
           + HP+E +ML+
Sbjct: 257 QLHPLEVDMLQ 267

[59][TOP]
>UniRef100_B6QBC3 Diphthine synthase n=1 Tax=Penicillium marneffei ATCC 18224
           RepID=B6QBC3_PENMQ
          Length = 284

 Score =  140 bits (353), Expect = 4e-32
 Identities = 65/128 (50%), Positives = 95/128 (74%), Gaps = 1/128 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P S+Y+++K+N  LGLHTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSYYDRVKENAQLGLHTLVLLDIKVKEQSLENMARG-RKIYEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-TH 358
           +LE E++  + VYG D+  +G AR+G+ DQ +VAGT+K+L  VD G PLH LV++G+  H
Sbjct: 197 MLETEEERQEGVYGPDSLAIGAARVGAPDQKLVAGTLKELTGVDMGKPLHSLVLLGKRAH 256

Query: 359 PVEEEMLE 382
            +E++ +E
Sbjct: 257 DLEKDYIE 264

[60][TOP]
>UniRef100_UPI00017B4719 UPI00017B4719 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4719
          Length = 290

 Score =  140 bits (352), Expect = 6e-32
 Identities = 69/131 (52%), Positives = 97/131 (74%), Gaps = 4/131 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SFY+KI KNR  GLHTLCLLDI+VKE + E++ R G+K YEPPR+M+V  A +Q
Sbjct: 140 DTWRPESFYDKICKNREAGLHTLCLLDIKVKEQSEENMMR-GRKIYEPPRFMTVAQAADQ 198

Query: 182 LLEVEQK---HGDSV-YGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           L+++ Q+    G+ +   EDT CVG ARLG+++Q I   T++QL S D G PLH L++ G
Sbjct: 199 LMQIVQRRRGEGEELGLTEDTLCVGVARLGADNQAIRVATLQQLVSCDLGGPLHSLMVTG 258

Query: 350 ETHPVEEEMLE 382
           + HP+E +ML+
Sbjct: 259 QLHPLEVDMLQ 269

[61][TOP]
>UniRef100_Q4T2L8 Diphthine synthase (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4T2L8_TETNG
          Length = 268

 Score =  140 bits (352), Expect = 6e-32
 Identities = 69/131 (52%), Positives = 97/131 (74%), Gaps = 4/131 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SFY+KI KNR  GLHTLCLLDI+VKE + E++ R G+K YEPPR+M+V  A +Q
Sbjct: 138 DTWRPESFYDKICKNREAGLHTLCLLDIKVKEQSEENMMR-GRKIYEPPRFMTVAQAADQ 196

Query: 182 LLEVEQK---HGDSV-YGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           L+++ Q+    G+ +   EDT CVG ARLG+++Q I   T++QL S D G PLH L++ G
Sbjct: 197 LMQIVQRRRGEGEELGLTEDTLCVGVARLGADNQAIRVATLQQLVSCDLGGPLHSLMVTG 256

Query: 350 ETHPVEEEMLE 382
           + HP+E +ML+
Sbjct: 257 QLHPLEVDMLQ 267

[62][TOP]
>UniRef100_B8M3D2 Diphthine synthase n=1 Tax=Talaromyces stipitatus ATCC 10500
           RepID=B8M3D2_TALSN
          Length = 284

 Score =  140 bits (352), Expect = 6e-32
 Identities = 65/128 (50%), Positives = 94/128 (73%), Gaps = 1/128 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P S+Y+++K+N  LGLHTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSYYDRVKENAQLGLHTLVLLDIKVKEQSLENMARG-RKIYEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-TH 358
           +LE E++  + VYG D+  +G AR+G+ DQ +VAGT+K+L  VD G PLH LV++G+  H
Sbjct: 197 MLETEEERQEGVYGPDSLAIGAARVGAPDQKLVAGTLKELAEVDMGRPLHSLVLLGKRAH 256

Query: 359 PVEEEMLE 382
            +E + +E
Sbjct: 257 DLERDYIE 264

[63][TOP]
>UniRef100_Q6DV12 Diphthine synthase n=1 Tax=Gekko japonicus RepID=Q6DV12_GECJA
          Length = 278

 Score =  139 bits (351), Expect = 8e-32
 Identities = 67/133 (50%), Positives = 95/133 (71%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P+SF++KI KN+  G+HTLCLLDI+VKE + E+L R GKK Y+PPRYM VN A EQ
Sbjct: 138 DTWKPESFFDKITKNKKNGMHTLCLLDIKVKEQSLENLMR-GKKIYDPPRYMRVNEAAEQ 196

Query: 182 LLEV----EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LL +     Q+  +    EDT CVG AR+G+ DQ I +GT++++ + + G PLH ++I G
Sbjct: 197 LLAIVQNRRQEGEEPKVTEDTVCVGLARVGAVDQKIASGTLQEMITAELGGPLHSMIITG 256

Query: 350 ETHPVEEEMLEFY 388
             HP+E EML+ +
Sbjct: 257 ILHPLEIEMLKLF 269

[64][TOP]
>UniRef100_C3YA13 Diphthine synthase n=1 Tax=Branchiostoma floridae
           RepID=C3YA13_BRAFL
          Length = 285

 Score =  139 bits (351), Expect = 8e-32
 Identities = 70/134 (52%), Positives = 89/134 (66%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+PDS+Y+KI  NR  G HTLCLLDI+VKE + E+L +G +K YEPPRYM+V  A EQ
Sbjct: 138 DDWKPDSYYDKIAANREKGWHTLCLLDIKVKEQSIENLMKG-RKIYEPPRYMTVKQAAEQ 196

Query: 182 LLEVEQKHGDS-----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV 346
            LE+ QK  +         EDT CVG AR+G++ Q I AGT+ QL   D G PLH LVI 
Sbjct: 197 FLEIVQKKKEQGAEKQAIEEDTICVGLARIGTDTQQIAAGTLTQLAETDMGGPLHSLVIP 256

Query: 347 GETHPVEEEMLEFY 388
           G  HP+E +ML  +
Sbjct: 257 GHMHPLEIDMLRHF 270

[65][TOP]
>UniRef100_Q9H2P9-4 Isoform 4 of Diphthine synthase n=1 Tax=Homo sapiens RepID=Q9H2P9-4
          Length = 285

 Score =  139 bits (351), Expect = 8e-32
 Identities = 70/130 (53%), Positives = 95/130 (73%), Gaps = 5/130 (3%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P+SF++K+KKNR  G+HTLCLLDI+VKE + E+L + G+K YEPPRYMSVN A +QLLE+
Sbjct: 142 PESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIK-GRKIYEPPRYMSVNQAAQQLLEI 200

Query: 194 EQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETH 358
            Q    +  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  G  H
Sbjct: 201 VQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIH 260

Query: 359 PVEEEMLEFY 388
           P+E EML  +
Sbjct: 261 PMEMEMLSLF 270

[66][TOP]
>UniRef100_UPI0000ECB2AA Probable diphthine synthase (EC 2.1.1.98) (Diphthamide biosynthesis
           methyltransferase). n=2 Tax=Gallus gallus
           RepID=UPI0000ECB2AA
          Length = 286

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/137 (48%), Positives = 97/137 (70%), Gaps = 4/137 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P+SF++KIK+NR  G+HTLCLLDI+VKE + ++L +G +K YEP RYMSVN A EQ
Sbjct: 139 DTWKPESFFDKIKRNRQNGMHTLCLLDIKVKEQSLDNLMKG-RKIYEPSRYMSVNQAAEQ 197

Query: 182 LLEVEQKHG----DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LL++ +       +    E+T CVG AR+G+ DQ I +GT+ Q+ +V+ G PLH +++ G
Sbjct: 198 LLDIIRNRRLQGEEPEITENTICVGLARVGAPDQKIASGTLYQMSTVELGGPLHSMIVTG 257

Query: 350 ETHPVEEEMLEFYKYKS 400
             HP+E EML+ +   S
Sbjct: 258 TMHPLELEMLKLFSVDS 274

[67][TOP]
>UniRef100_C4YCK9 Diphthine synthase n=1 Tax=Clavispora lusitaniae ATCC 42720
           RepID=C4YCK9_CLAL4
          Length = 300

 Score =  139 bits (350), Expect = 1e-31
 Identities = 69/127 (54%), Positives = 91/127 (71%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM ++TA +Q
Sbjct: 139 ETWKPDSFYAKIMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDISTAAKQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+   +  Y  +T CV  +RLGS  QT  AGT+K+L   D GAPLH LV++G + H
Sbjct: 198 LLEIEEIRKEQAYTPETPCVAVSRLGSPTQTFKAGTLKELSEYDAGAPLHSLVMLGRQVH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 DLELEYL 264

[68][TOP]
>UniRef100_Q6BN80 Diphthine synthase n=1 Tax=Debaryomyces hansenii RepID=DPH5_DEBHA
          Length = 300

 Score =  139 bits (350), Expect = 1e-31
 Identities = 69/130 (53%), Positives = 91/130 (70%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG K  YEPPRYM++ TA  Q
Sbjct: 139 ETWKPDSFYNKIMENRRIGLHTLLLLDIKVKEQSIENMARG-KLIYEPPRYMNIETAASQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+   +  Y  +T CV  +RLGS +QT  AGT+++L   D G PLH LV++G + H
Sbjct: 198 LLEIEEMRQEKAYTPNTPCVAISRLGSPEQTFKAGTLQELSEYDSGEPLHSLVMLGRQVH 257

Query: 359 PVEEEMLEFY 388
            +E E L  Y
Sbjct: 258 DLELEYLYEY 267

[69][TOP]
>UniRef100_C4R138 Diphthine synthase n=1 Tax=Pichia pastoris GS115 RepID=C4R138_PICPG
          Length = 299

 Score =  138 bits (347), Expect = 2e-31
 Identities = 70/130 (53%), Positives = 93/130 (71%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFYEKI  NR LGLHTL LLDI+VKE +FE++ +G K  YEPPRYM++ TA +Q
Sbjct: 139 DSWKPDSFYEKIMGNRKLGLHTLILLDIKVKEQSFENMMKG-KLIYEPPRYMNIATAAQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           L+EVE+   +  Y E+T CV  +RLG+  Q   AGT+K+L S D G PLH LV++G + H
Sbjct: 198 LIEVEETKKEQAYTENTPCVAVSRLGAPTQKFKAGTLKELASYDSGEPLHSLVMLGRQLH 257

Query: 359 PVEEEMLEFY 388
            +E E L  Y
Sbjct: 258 DLELEYLYEY 267

[70][TOP]
>UniRef100_UPI000186C9F4 diphthine synthase, putative n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186C9F4
          Length = 273

 Score =  137 bits (345), Expect = 4e-31
 Identities = 68/129 (52%), Positives = 91/129 (70%), Gaps = 4/129 (3%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           TW+PDSF+EKI  NR  GLHTLCLLDI+VKEPT ES+ +  KK+Y PP +M+VNTA  QL
Sbjct: 139 TWKPDSFFEKILSNRLRGLHTLCLLDIKVKEPTLESIMK-KKKEYMPPMFMTVNTAATQL 197

Query: 185 LEVEQKHGDSVYG----EDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE 352
           L++     +   G    E+T+CVG AR+GS DQ I+  ++K++E VD G PLH L+I G+
Sbjct: 198 LQILNNFSNGEQGHCLDEETKCVGLARIGSSDQKIIFCSLKEMEKVDLGKPLHSLIIPGK 257

Query: 353 THPVEEEML 379
              +EE+ L
Sbjct: 258 LQILEEQYL 266

[71][TOP]
>UniRef100_B6K2J6 Diphthine synthase n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6K2J6_SCHJY
          Length = 283

 Score =  137 bits (344), Expect = 5e-31
 Identities = 68/132 (51%), Positives = 94/132 (71%), Gaps = 1/132 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           +RP SFY++IK+N  LG HTL LLDI+VKE ++E+L RG +K YEPPRYMS + A +Q+L
Sbjct: 140 YRPQSFYDRIKENAELGFHTLVLLDIKVKEQSWENLARG-RKIYEPPRYMSASLAAQQML 198

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-THPV 364
           EVE++ G+ +   +T  V  ARLGS+DQTI AGT+ +L   D GAPLH +VI+G+  H +
Sbjct: 199 EVEEERGEGICSPETLAVAVARLGSDDQTIKAGTLAELAETDVGAPLHSMVIIGKNVHDL 258

Query: 365 EEEMLEFYKYKS 400
           E + L  +   S
Sbjct: 259 EIDFLRAFAVNS 270

[72][TOP]
>UniRef100_C5G7N8 Diphthine synthase n=2 Tax=Ajellomyces dermatitidis
           RepID=C5G7N8_AJEDR
          Length = 285

 Score =  136 bits (343), Expect = 6e-31
 Identities = 63/127 (49%), Positives = 92/127 (72%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSFYDRVKENVQLGFHTLMLLDIKVKEQSIENMARG-RKIYEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E++  + VYG  +  +G AR+G+ DQ +  GT+K+L  VD G PLHCLV++G +TH
Sbjct: 197 MLEIEEERKECVYGPTSLAIGAARVGAPDQKLAVGTLKELCDVDMGKPLHCLVLLGKKTH 256

Query: 359 PVEEEML 379
            +E + +
Sbjct: 257 DLERDYI 263

[73][TOP]
>UniRef100_A3LVJ1 Diphthine synthase n=1 Tax=Pichia stipitis RepID=A3LVJ1_PICST
          Length = 301

 Score =  136 bits (343), Expect = 6e-31
 Identities = 67/130 (51%), Positives = 89/130 (68%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++WRPDSFY K+ +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA  Q
Sbjct: 139 DSWRPDSFYNKVMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATAASQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+  G+  Y  DT CV  +RLGS  QT  A ++K+L   D G PLH LV++G + H
Sbjct: 198 LLEIEELRGEKAYTPDTPCVAISRLGSPSQTFKAASLKELAEFDSGEPLHSLVMLGRQVH 257

Query: 359 PVEEEMLEFY 388
            +E E L  Y
Sbjct: 258 DLELEYLYQY 267

[74][TOP]
>UniRef100_UPI0001AE7913 UPI0001AE7913 related cluster n=1 Tax=Homo sapiens
           RepID=UPI0001AE7913
          Length = 234

 Score =  136 bits (342), Expect = 8e-31
 Identities = 69/128 (53%), Positives = 92/128 (71%), Gaps = 5/128 (3%)
 Frame = +2

Query: 20  SFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQ 199
           SF++K+KKNR  G+HTLCLLDI+VKE + E+L +G +K YEPPRYMSVN A +QLLE+ Q
Sbjct: 93  SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKG-RKIYEPPRYMSVNQAAQQLLEIVQ 151

Query: 200 KHG----DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETHPV 364
                  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  G  HP+
Sbjct: 152 NQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPM 211

Query: 365 EEEMLEFY 388
           E EML  +
Sbjct: 212 EMEMLSLF 219

[75][TOP]
>UniRef100_B8N6Y6 Diphthine synthase n=2 Tax=Aspergillus RepID=B8N6Y6_ASPFN
          Length = 285

 Score =  136 bits (342), Expect = 8e-31
 Identities = 65/127 (51%), Positives = 93/127 (73%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P S+Y+KIK+N SLGLHTL LLDI+VKE ++E++ RG +  YEPPRYM+V     Q
Sbjct: 138 ENWKPSSYYDKIKENISLGLHTLVLLDIKVKEQSYENMARG-RLIYEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + VYG D+  VG AR+G+ DQ +V GT+K+L  V+ GAPLH LV++G   H
Sbjct: 197 MLETEEERKEGVYGPDSLAVGAARVGAPDQKLVVGTLKELAEVEMGAPLHSLVLLGRRAH 256

Query: 359 PVEEEML 379
            +E++ +
Sbjct: 257 DLEKDYI 263

[76][TOP]
>UniRef100_A5E2P7 Diphthine synthase n=1 Tax=Lodderomyces elongisporus
           RepID=A5E2P7_LODEL
          Length = 300

 Score =  136 bits (342), Expect = 8e-31
 Identities = 66/127 (51%), Positives = 90/127 (70%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 140 DSWKPDSFYNKIMENRKIGLHTLILLDIKVKEQSIENMARG-RLIYEPPRYMDIATACKQ 198

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           L+E+E+  G+  Y E+T CV  +RLGS  Q   AGT+K+L   D G PLH LV++G + H
Sbjct: 199 LIEIEELRGEQAYTENTPCVAVSRLGSPTQKFKAGTLKELSEYDSGEPLHTLVMLGRQVH 258

Query: 359 PVEEEML 379
            +E E L
Sbjct: 259 DLELEYL 265

[77][TOP]
>UniRef100_Q9H2P9-3 Isoform 3 of Diphthine synthase n=1 Tax=Homo sapiens RepID=Q9H2P9-3
          Length = 234

 Score =  136 bits (342), Expect = 8e-31
 Identities = 69/128 (53%), Positives = 92/128 (71%), Gaps = 5/128 (3%)
 Frame = +2

Query: 20  SFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQ 199
           SF++K+KKNR  G+HTLCLLDI+VKE + E+L +G +K YEPPRYMSVN A +QLLE+ Q
Sbjct: 93  SFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKG-RKIYEPPRYMSVNQAAQQLLEIVQ 151

Query: 200 KHG----DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETHPV 364
                  +    E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  G  HP+
Sbjct: 152 NQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPM 211

Query: 365 EEEMLEFY 388
           E EML  +
Sbjct: 212 EMEMLSLF 219

[78][TOP]
>UniRef100_Q0UYM3 Diphthine synthase n=1 Tax=Phaeosphaeria nodorum RepID=Q0UYM3_PHANO
          Length = 227

 Score =  135 bits (340), Expect = 1e-30
 Identities = 69/129 (53%), Positives = 95/129 (73%), Gaps = 2/129 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+P SFY++IK+N S+GLHTL LLDI+VKE + E++ R G+K YEPPRYM+V    +Q
Sbjct: 79  DNWKPASFYDRIKENVSIGLHTLVLLDIKVKEQSLENMAR-GRKIYEPPRYMTVAQCAQQ 137

Query: 182 LLEVEQ-KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-T 355
           +LEVE+    + VY +D+  VG AR+G+EDQ IVAGT+ QL   D G PLH LV++G+ T
Sbjct: 138 MLEVEEDDKKEGVYTKDSLAVGVARIGAEDQKIVAGTLAQLCGADLGKPLHSLVLLGKRT 197

Query: 356 HPVEEEMLE 382
           H +E + LE
Sbjct: 198 HDLERDFLE 206

[79][TOP]
>UniRef100_C1FYG3 Diphthine synthase n=1 Tax=Paracoccidioides brasiliensis Pb18
           RepID=C1FYG3_PARBD
          Length = 285

 Score =  135 bits (340), Expect = 1e-30
 Identities = 64/127 (50%), Positives = 94/127 (74%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V+    Q
Sbjct: 138 ETWKPSSFYDRVKENVQLGFHTLMLLDIKVKEQSIENMERG-RKIYEPPRYMTVSQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E++  + VYG D+  VG AR+G+ +Q +V GT+K+L  VD G PLH LV++G +TH
Sbjct: 197 MLEIEEERKEGVYGPDSLAVGAARVGAPNQQLVVGTLKELCDVDMGKPLHSLVLLGKKTH 256

Query: 359 PVEEEML 379
            +E + +
Sbjct: 257 DLERDYI 263

[80][TOP]
>UniRef100_C0S3Z9 Diphthine synthase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0S3Z9_PARBP
          Length = 285

 Score =  135 bits (340), Expect = 1e-30
 Identities = 64/127 (50%), Positives = 94/127 (74%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V+    Q
Sbjct: 138 ETWKPSSFYDRVKENVQLGFHTLMLLDIKVKEQSIENMERG-RKIYEPPRYMTVSQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E++  + VYG D+  VG AR+G+ +Q +V GT+K+L  VD G PLH LV++G +TH
Sbjct: 197 MLEIEEERKEGVYGPDSLAVGAARVGAPNQQLVVGTLKELCDVDMGKPLHSLVLLGKKTH 256

Query: 359 PVEEEML 379
            +E + +
Sbjct: 257 DLERDYI 263

[81][TOP]
>UniRef100_B3M004 Diphthine synthase n=1 Tax=Drosophila ananassae RepID=B3M004_DROAN
          Length = 281

 Score =  135 bits (339), Expect = 2e-30
 Identities = 71/134 (52%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MSV  A  Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMSVAEAAHQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G E Q I  GT+ ++ S D G PLH L+I  
Sbjct: 197 LLAIVEKKDSLEKNTVLNEQSLCVGLARVGQESQQIAVGTLLEMRSTDMGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[82][TOP]
>UniRef100_Q8IN02 Diphthine synthase n=1 Tax=Drosophila melanogaster
           RepID=Q8IN02_DROME
          Length = 281

 Score =  134 bits (337), Expect = 3e-30
 Identities = 70/134 (52%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+M+V  A  Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMTVAEAAHQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G E Q I  GT+ ++ S D G PLH L+I  
Sbjct: 197 LLSIVEKKDSLEKNTVLNEQSLCVGLARVGQESQQIAVGTLLEMRSTDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[83][TOP]
>UniRef100_B4PMB9 Diphthine synthase n=3 Tax=melanogaster subgroup RepID=B4PMB9_DROYA
          Length = 281

 Score =  134 bits (337), Expect = 3e-30
 Identities = 70/134 (52%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+M+V  A  Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMTVAEAAHQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G E Q I  GT+ ++ S D G PLH L+I  
Sbjct: 197 LLSIVEKKDSLEKNTVLNEQSLCVGLARVGQESQQIAVGTLLEMRSTDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[84][TOP]
>UniRef100_C4WWV1 Diphthine synthase n=1 Tax=Acyrthosiphon pisum RepID=C4WWV1_ACYPI
          Length = 273

 Score =  134 bits (336), Expect = 4e-30
 Identities = 66/136 (48%), Positives = 95/136 (69%), Gaps = 3/136 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+P SF +KI +N+S GLHTLCLLDI+VKEPT+ES+ +  KK+Y+P R+M V  A  Q
Sbjct: 138 DIWKPSSFLKKINQNKSNGLHTLCLLDIQVKEPTWESITKK-KKEYQPSRFMEVKQACSQ 196

Query: 182 LLEVEQKH---GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE 352
           LL++   +   G++    ++ CVG AR+G  DQ IVAG + ++ +VD G PLH +VIVG 
Sbjct: 197 LLQIIDSNEFDGENYVTRESLCVGAARIGWPDQKIVAGALAEMVNVDMGPPLHSIVIVGT 256

Query: 353 THPVEEEMLEFYKYKS 400
            HP+EE+ L+ +  KS
Sbjct: 257 LHPLEEQFLKQFYIKS 272

[85][TOP]
>UniRef100_C4LWZ7 Diphthine synthase n=1 Tax=Entamoeba histolytica HM-1:IMSS
           RepID=C4LWZ7_ENTHI
          Length = 271

 Score =  133 bits (335), Expect = 5e-30
 Identities = 70/133 (52%), Positives = 90/133 (67%), Gaps = 1/133 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRP S+Y KIK NR   +HTL LLDI+VKE + E++ +G +  +EPPRYM++N  IEQ
Sbjct: 138 EHWRPSSYYPKIKINRDNNMHTLVLLDIKVKERSEENIIKG-RDIFEPPRYMTINQCIEQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-VGETH 358
           LLEVE++    VY EDT  VG AR+   DQ IV G MK L   DFGAP+HCL+I   +  
Sbjct: 197 LLEVEKEQHLGVYDEDTMVVGMARVACADQKIVYGKMKDLLHYDFGAPMHCLLIPAPQVD 256

Query: 359 PVEEEMLEFYKYK 397
             E + LE++KYK
Sbjct: 257 DPELDHLEYFKYK 269

[86][TOP]
>UniRef100_B4HEQ0 Diphthine synthase n=1 Tax=Drosophila sechellia RepID=B4HEQ0_DROSE
          Length = 281

 Score =  133 bits (335), Expect = 5e-30
 Identities = 70/134 (52%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+M+V  A  Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMTVAEAAYQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G E Q I  GT+ ++ S D G PLH L+I  
Sbjct: 197 LLSIVEKKDSLEKNTVLNEQSLCVGLARVGQESQQIAVGTLLEMRSTDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[87][TOP]
>UniRef100_B0E635 Diphthine synthase n=1 Tax=Entamoeba dispar SAW760
           RepID=B0E635_ENTDI
          Length = 271

 Score =  133 bits (335), Expect = 5e-30
 Identities = 70/134 (52%), Positives = 91/134 (67%), Gaps = 1/134 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P S+Y KIK NR   +HTL LLDI+VKE + E++ +G +  +EPPRYM++N  IEQ
Sbjct: 138 EHWKPSSYYPKIKINRDNNMHTLVLLDIKVKERSEENIIKG-RDIFEPPRYMTINQCIEQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-VGETH 358
           LLEVE++    VY EDT  VG AR+   DQ IV G MK L   DFGAP+HCL+I   +  
Sbjct: 197 LLEVEKEQHLGVYDEDTMVVGMARVACADQKIVYGKMKDLLRYDFGAPMHCLLIPAPQID 256

Query: 359 PVEEEMLEFYKYKS 400
             E + LE++KYKS
Sbjct: 257 DPELDHLEYFKYKS 270

[88][TOP]
>UniRef100_B2VVE1 Diphthine synthase n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP
           RepID=B2VVE1_PYRTR
          Length = 286

 Score =  133 bits (335), Expect = 5e-30
 Identities = 67/129 (51%), Positives = 94/129 (72%), Gaps = 2/129 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+P SFY++IK+N S+GLHTL LLDI+VKE + E++ R G+K YEPPRYM+V    +Q
Sbjct: 138 DNWKPASFYDRIKENVSIGLHTLVLLDIKVKEQSLENMAR-GRKIYEPPRYMTVAQCAQQ 196

Query: 182 LLEVEQK-HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-T 355
           +LE+E+    +  Y +D+  VG AR+G+EDQ IVAGT+ QL   D G PLH LV++G+ T
Sbjct: 197 MLEIEEDVKKEGAYTKDSLAVGVARIGAEDQQIVAGTLAQLCEADLGKPLHSLVLLGKRT 256

Query: 356 HPVEEEMLE 382
           H +E + LE
Sbjct: 257 HDLERDFLE 265

[89][TOP]
>UniRef100_A1CP60 Diphthine synthase n=1 Tax=Aspergillus clavatus RepID=A1CP60_ASPCL
          Length = 285

 Score =  133 bits (335), Expect = 5e-30
 Identities = 61/127 (48%), Positives = 92/127 (72%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P S+Y+++K+N  LGLHTL LLDI+VKE + E++ RG ++ +EPPRYM+V     Q
Sbjct: 138 ETWKPSSYYDRVKENVQLGLHTLVLLDIKVKEQSLENMARG-RRVFEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + V+G D+  +G AR+G+ DQ +VAGT+K+L  VD G PLH LV++G   H
Sbjct: 197 MLETEEERKEGVFGPDSLAIGAARVGAPDQKLVAGTLKELSEVDMGQPLHSLVLLGRRAH 256

Query: 359 PVEEEML 379
            +E + +
Sbjct: 257 DLERDYI 263

[90][TOP]
>UniRef100_O74898 Diphthine synthase n=1 Tax=Schizosaccharomyces pombe
           RepID=DPH5_SCHPO
          Length = 283

 Score =  133 bits (335), Expect = 5e-30
 Identities = 67/128 (52%), Positives = 92/128 (71%), Gaps = 1/128 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           +RP SFY+ IK+N SLGLHTL LLDI+VKE ++E+L RG +K YEPPRYMS + A +Q+L
Sbjct: 140 YRPQSFYDHIKENVSLGLHTLVLLDIKVKEQSWENLARG-RKVYEPPRYMSASLAAQQML 198

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETHPV 364
           EVE+   +++   D+ CV   R+GS+DQ I AGT+++L   D G PLH +V+VG + H +
Sbjct: 199 EVEEDRQENICTPDSLCVAVGRMGSDDQVIFAGTLQELAEHDIGPPLHSVVLVGRDVHDL 258

Query: 365 EEEMLEFY 388
           E E L  Y
Sbjct: 259 ELEFLRAY 266

[91][TOP]
>UniRef100_Q6FXK9 Diphthine synthase n=1 Tax=Candida glabrata RepID=DPH5_CANGA
          Length = 298

 Score =  133 bits (335), Expect = 5e-30
 Identities = 67/130 (51%), Positives = 93/130 (71%), Gaps = 2/130 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++WRPDS+Y+K+ +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYMS+    +Q
Sbjct: 139 DSWRPDSWYDKVMENRKIGLHTLVLLDIKVKEQSLENMARG-RLIYEPPRYMSIAQCCQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+   +  Y  DT  VG +RLGS  Q+  AGT+K+L   D G PLH LVI+G ++H
Sbjct: 198 LLEIEELRAEKAYTADTPVVGISRLGSPTQSFKAGTIKELAEYDAGEPLHSLVILGRQSH 257

Query: 359 PVE-EEMLEF 385
            +E E +LEF
Sbjct: 258 ELELEYLLEF 267

[92][TOP]
>UniRef100_B4NAV5 Diphthine synthase n=1 Tax=Drosophila willistoni RepID=B4NAV5_DROWI
          Length = 281

 Score =  133 bits (334), Expect = 7e-30
 Identities = 70/134 (52%), Positives = 91/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MSV  A  Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMSVAEAAHQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G + Q IV  T++++ S D G PLH L+I  
Sbjct: 197 LLSIVEKKDALERNTVLNEQSLCVGLARVGQDTQQIVVTTLQEMRSTDLGQPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[93][TOP]
>UniRef100_C5MHI8 Diphthine synthase n=1 Tax=Candida tropicalis MYA-3404
           RepID=C5MHI8_CANTT
          Length = 299

 Score =  133 bits (334), Expect = 7e-30
 Identities = 65/127 (51%), Positives = 89/127 (70%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 DSWKPDSFYPKIMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATACQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+   +  Y  +T CV  +RLGS  QT  AGT+++L   D G PLH LV++G + H
Sbjct: 198 LLEIEEARQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYDSGEPLHSLVMLGRQVH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 DLELEYL 264

[94][TOP]
>UniRef100_P32469 Diphthine synthase n=6 Tax=Saccharomyces cerevisiae
           RepID=DPH5_YEAST
          Length = 300

 Score =  133 bits (334), Expect = 7e-30
 Identities = 68/130 (52%), Positives = 91/130 (70%), Gaps = 2/130 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDS+Y+KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYMS+    EQ
Sbjct: 139 DNWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARG-RLIYEPPRYMSIAQCCEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+K G   Y  DT  V  +RLGS  Q+  +GT+ +L + D G PLH LVI+G + H
Sbjct: 198 LLEIEEKRGTKAYTPDTPAVAISRLGSSSQSFKSGTISELANYDSGEPLHSLVILGRQCH 257

Query: 359 PVE-EEMLEF 385
            +E E +LEF
Sbjct: 258 ELELEYLLEF 267

[95][TOP]
>UniRef100_B4M179 Diphthine synthase n=1 Tax=Drosophila virilis RepID=B4M179_DROVI
          Length = 281

 Score =  132 bits (333), Expect = 9e-30
 Identities = 69/134 (51%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MSV  A +Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTLESLMR-KRKEYMPPRFMSVAEAAQQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G + Q IV  T+  + + D G PLH L+I  
Sbjct: 197 LLTIVEKKDALERNTVLNEQSLCVGLARVGQDTQQIVVSTLHGMRATDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[96][TOP]
>UniRef100_B6HAE6 Diphthine synthase n=1 Tax=Penicillium chrysogenum Wisconsin
           54-1255 RepID=B6HAE6_PENCW
          Length = 285

 Score =  132 bits (333), Expect = 9e-30
 Identities = 61/130 (46%), Positives = 95/130 (73%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P S+Y+++++N   GLHTL LLDI+VKE + E++ RG ++ +EPPRYM+V     Q
Sbjct: 138 ETWKPSSYYDRVRENVQTGLHTLVLLDIKVKEQSLENMARG-RRIFEPPRYMTVAQCAAQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + VYG D+  VG AR+G+ +Q +V+GT+K+L +V+ GAPLH LV++G  TH
Sbjct: 197 MLETEEERQEGVYGPDSLAVGAARVGAANQQLVSGTLKELSTVEMGAPLHSLVLLGRRTH 256

Query: 359 PVEEEMLEFY 388
            +E + +  Y
Sbjct: 257 DLERDYIREY 266

[97][TOP]
>UniRef100_A5DNB0 Diphthine synthase n=1 Tax=Pichia guilliermondii RepID=A5DNB0_PICGU
          Length = 296

 Score =  132 bits (333), Expect = 9e-30
 Identities = 64/128 (50%), Positives = 89/128 (69%), Gaps = 1/128 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+K+ +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 ETWKPASFYDKVLENRRIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATAAKQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E+  G   Y  D+ CV  +RLGS  QT  AGT+ ++   D G PLH LV++G + H
Sbjct: 198 MLEIEELKGQKAYTPDSPCVAISRLGSPTQTFKAGTLAEMAEYDSGEPLHSLVLMGRQVH 257

Query: 359 PVEEEMLE 382
            +E E L+
Sbjct: 258 DLELEYLD 265

[98][TOP]
>UniRef100_A2QRU1 Diphthine synthase n=1 Tax=Aspergillus niger CBS 513.88
           RepID=A2QRU1_ASPNC
          Length = 285

 Score =  132 bits (333), Expect = 9e-30
 Identities = 61/127 (48%), Positives = 93/127 (73%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P S+Y+++K+N  LGLHTL LLDI+VKEP+ E++ RG +  YEPPR+M+V     Q
Sbjct: 138 ENWKPSSYYDRVKENVQLGLHTLVLLDIKVKEPSLENMARG-RLVYEPPRFMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-TH 358
           +LE E++  + V+G D+  VG AR+G+ DQ +VAGT+K+L  V+ G PLH LV++G+  H
Sbjct: 197 MLETEEERQEGVWGPDSLAVGAARVGAADQKLVAGTLKELAEVEMGRPLHSLVLIGKRAH 256

Query: 359 PVEEEML 379
            +E++ +
Sbjct: 257 DLEKDYI 263

[99][TOP]
>UniRef100_UPI0001926B91 PREDICTED: similar to B0491.7, partial n=1 Tax=Hydra magnipapillata
           RepID=UPI0001926B91
          Length = 159

 Score =  132 bits (332), Expect = 1e-29
 Identities = 66/135 (48%), Positives = 88/135 (65%), Gaps = 6/135 (4%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDSFY+KI  N+   LHTLCLLDI+VKE + E++ RG K  +EPPRY++ N AI Q
Sbjct: 15  DNWRPDSFYDKIIANKERKLHTLCLLDIKVKEQSIENMMRG-KAIFEPPRYLTANEAINQ 73

Query: 182 LLEV------EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI 343
           LLEV       +     V  + + CV  AR+G EDQ IV GTM ++  +D G P+H L+I
Sbjct: 74  LLEVTNERRLNKNEKKQVLDDSSFCVALARVGWEDQKIVFGTMNEVSKIDLGPPIHSLII 133

Query: 344 VGETHPVEEEMLEFY 388
            GE H +E EML+ +
Sbjct: 134 PGEIHYIENEMLQLF 148

[100][TOP]
>UniRef100_B2AN92 Diphthine synthase n=1 Tax=Podospora anserina RepID=B2AN92_PODAN
          Length = 287

 Score =  132 bits (332), Expect = 1e-29
 Identities = 65/127 (51%), Positives = 91/127 (71%), Gaps = 3/127 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRP SFY++IK+NR +GLHTL LLDI+VKE + E++ RG +K YEPPRYM+V T   Q
Sbjct: 138 DNWRPASFYDRIKENRQIGLHTLVLLDIKVKEQSLENMARG-RKIYEPPRYMTVGTCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVD--FGAPLHCLVIVG-E 352
           +LEVE++  + VYG D+  +G AR+G + +  VAGT+K+L   D   G PLH LV++G  
Sbjct: 197 MLEVEEEKKEGVYGPDSLAIGAARVGGKTEKFVAGTLKELCDADELLGGPLHSLVLLGRR 256

Query: 353 THPVEEE 373
           TH +E +
Sbjct: 257 THELEHD 263

[101][TOP]
>UniRef100_B9WHS2 Diphthine synthase n=1 Tax=Candida dubliniensis CD36
           RepID=B9WHS2_CANDC
          Length = 299

 Score =  132 bits (331), Expect = 2e-29
 Identities = 65/127 (51%), Positives = 88/127 (69%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 DTWKPDSFYGKIMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATAAQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E    +  Y  +T CV  +RLGS  QT  AGT+++L   + G PLH LV++G + H
Sbjct: 198 LLEIESMRQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYESGEPLHSLVMLGRQVH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 ELELEYL 264

[102][TOP]
>UniRef100_Q29BK7 Diphthine synthase n=1 Tax=Drosophila pseudoobscura pseudoobscura
           RepID=Q29BK7_DROPS
          Length = 281

 Score =  131 bits (330), Expect = 2e-29
 Identities = 69/134 (51%), Positives = 89/134 (66%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+K+K NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MSV  A  Q
Sbjct: 138 ETWKPDSFYDKVKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMSVAEAAHQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G E Q I   T+ ++ S D G PLH L+I  
Sbjct: 197 LLNIVEKKDALERNTVLNEQSLCVGLARVGQETQQIAVTTLLEMRSTDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[103][TOP]
>UniRef100_B7P2M4 Diphthine synthase n=1 Tax=Ixodes scapularis RepID=B7P2M4_IXOSC
          Length = 288

 Score =  131 bits (330), Expect = 2e-29
 Identities = 59/136 (43%), Positives = 93/136 (68%), Gaps = 7/136 (5%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E+W+P S+Y+KI  NR  GLHTLCLLDI++KE T E++ +G +  YEPPR+M+ + A +Q
Sbjct: 138 ESWKPHSYYDKIAANRRRGLHTLCLLDIKMKEKTVENIIKG-RDIYEPPRFMTASEAADQ 196

Query: 182 LLEVEQK-------HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLV 340
           LL++ +         G+  Y E++ C+G AR+G+E Q +V  +++ + S D G PLH L+
Sbjct: 197 LLQILETKKEEGIPEGELAYSENSMCIGLARVGTETQQVVCASLRDMSSCDLGGPLHSLI 256

Query: 341 IVGETHPVEEEMLEFY 388
           + G+ HP+E EML+ +
Sbjct: 257 VPGKLHPMELEMLKLF 272

[104][TOP]
>UniRef100_B4GP41 Diphthine synthase n=1 Tax=Drosophila persimilis RepID=B4GP41_DROPE
          Length = 281

 Score =  131 bits (330), Expect = 2e-29
 Identities = 69/134 (51%), Positives = 89/134 (66%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+K+K NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MSV  A  Q
Sbjct: 138 ETWKPDSFYDKVKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMSVAEAAHQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G E Q I   T+ ++ S D G PLH L+I  
Sbjct: 197 LLNIVEKKDALERNTVLNEQSLCVGLARVGQETQQIAVTTLLEMRSTDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[105][TOP]
>UniRef100_C0NL37 Diphthine synthase n=1 Tax=Ajellomyces capsulatus G186AR
           RepID=C0NL37_AJECG
          Length = 285

 Score =  131 bits (330), Expect = 2e-29
 Identities = 62/123 (50%), Positives = 89/123 (72%), Gaps = 1/123 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSFYDRVKENVQLGFHTLMLLDIKVKEQSLENMARG-RKIYEPPRYMTVAQCARQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E++  + VYG  +  +G AR+G+ DQ +  GT+K+L  VD G PLH LV++G +TH
Sbjct: 197 MLEIEEERKECVYGPTSLAIGAARVGASDQHLAVGTLKELCDVDMGKPLHSLVLLGKKTH 256

Query: 359 PVE 367
            +E
Sbjct: 257 DLE 259

[106][TOP]
>UniRef100_A6R8T6 Diphthine synthase n=1 Tax=Ajellomyces capsulatus NAm1
           RepID=A6R8T6_AJECN
          Length = 285

 Score =  131 bits (330), Expect = 2e-29
 Identities = 62/123 (50%), Positives = 89/123 (72%), Gaps = 1/123 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSFYDRVKENVQLGFHTLMLLDIKVKEQSLENMARG-RKIYEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E++  + VYG  +  +G AR+G+ DQ +  GT+K+L  VD G PLH LV++G +TH
Sbjct: 197 MLEIEEERKECVYGPTSLAIGAARVGASDQHLAVGTLKELCDVDMGKPLHSLVLLGKKTH 256

Query: 359 PVE 367
            +E
Sbjct: 257 DLE 259

[107][TOP]
>UniRef100_UPI00002342D4 hypothetical protein AN0720.2 n=1 Tax=Aspergillus nidulans FGSC A4
           RepID=UPI00002342D4
          Length = 304

 Score =  131 bits (329), Expect = 3e-29
 Identities = 61/127 (48%), Positives = 93/127 (73%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P S+Y+++K+N  +GLHTL LLDI+VKE + E++ RG +  YEPPR+M+V     Q
Sbjct: 157 ETWKPSSYYDRVKENVQIGLHTLVLLDIKVKEQSLENMARG-RLIYEPPRFMTVAQCAAQ 215

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + V+G D+  VG AR+G+EDQ +VAGT+++L  VD G PLH LV++G   H
Sbjct: 216 MLETEEERQEGVWGPDSLAVGAARVGAEDQKLVAGTLQELTQVDMGRPLHSLVLLGRRAH 275

Query: 359 PVEEEML 379
            +E++ +
Sbjct: 276 DLEKDYI 282

[108][TOP]
>UniRef100_B4K7P6 Diphthine synthase n=1 Tax=Drosophila mojavensis RepID=B4K7P6_DROMO
          Length = 281

 Score =  131 bits (329), Expect = 3e-29
 Identities = 69/134 (51%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MSV  A +Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMSVAEAAQQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G + Q IV  T+  + + D G PLH L+I  
Sbjct: 197 LLTIVEKKDALERNTVLNEQSLCVGLARVGQDTQQIVVSTLHGMRATDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[109][TOP]
>UniRef100_B4JSH6 Diphthine synthase n=1 Tax=Drosophila grimshawi RepID=B4JSH6_DROGR
          Length = 281

 Score =  131 bits (329), Expect = 3e-29
 Identities = 69/134 (51%), Positives = 90/134 (67%), Gaps = 5/134 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL R  +K+Y PPR+MS   A +Q
Sbjct: 138 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMR-KRKEYMPPRFMSCAEAAQQ 196

Query: 182 LLEVEQK----HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           LL + +K      ++V  E + CVG AR+G   Q IV GT+  + ++D G PLH L+I  
Sbjct: 197 LLTIVEKKDALERNTVLNEQSLCVGLARVGQSTQQIVVGTLHGMRAMDLGGPLHSLIIPA 256

Query: 347 GETHPVEEEMLEFY 388
            E HP+E E L+ Y
Sbjct: 257 KEMHPLEVEFLQQY 270

[110][TOP]
>UniRef100_C4YRP0 Diphthine synthase n=1 Tax=Candida albicans RepID=C4YRP0_CANAL
          Length = 299

 Score =  131 bits (329), Expect = 3e-29
 Identities = 65/127 (51%), Positives = 88/127 (69%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 DSWKPDSFYGKIMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATAAQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E    +  Y  +T CV  +RLGS  QT  AGT+++L   D G PLH LV++G + H
Sbjct: 198 LLEIESIRQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYDSGEPLHSLVMLGRQVH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 ELELEYL 264

[111][TOP]
>UniRef100_A1D214 Diphthine synthase n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1D214_NEOFI
          Length = 285

 Score =  131 bits (329), Expect = 3e-29
 Identities = 60/127 (47%), Positives = 91/127 (71%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P S+Y+++K+N  LGLHTL LLDI+VKE ++E++ RG ++ +EPPRYM+V     Q
Sbjct: 138 ENWKPSSYYDRVKENVQLGLHTLVLLDIKVKEQSYENMARG-RRIFEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + V+G D+  VG AR+G  DQ +V GT+K+L  VD G PLH LV++G + H
Sbjct: 197 MLETEEERKEGVFGPDSLAVGAARVGGPDQKLVVGTLKELSEVDMGPPLHSLVLLGRKAH 256

Query: 359 PVEEEML 379
            +E + +
Sbjct: 257 DLERDYI 263

[112][TOP]
>UniRef100_Q7S949 Diphthine synthase n=1 Tax=Neurospora crassa RepID=DPH5_NEUCR
          Length = 287

 Score =  131 bits (329), Expect = 3e-29
 Identities = 62/129 (48%), Positives = 94/129 (72%), Gaps = 3/129 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRP SFY++IK+NRS+GLHTL LLDI+VKE + E++ RG +K YEPPRYM+V T  +Q
Sbjct: 138 DNWRPASFYDRIKENRSIGLHTLVLLDIKVKEQSLENMARG-RKIYEPPRYMTVGTCAQQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVD--FGAPLHCLVIVG-E 352
           +LE+E++  + VYG ++  +G AR+G + +  V+GT+K+L   D   G PLH L+++G  
Sbjct: 197 MLEIEEEKQEGVYGPESLAIGCARVGGKTEKFVSGTLKELCDADDLLGPPLHSLILLGRR 256

Query: 353 THPVEEEML 379
           TH +E + +
Sbjct: 257 THELEHDFV 265

[113][TOP]
>UniRef100_Q5BFG0 Diphthine synthase n=2 Tax=Emericella nidulans RepID=DPH5_EMENI
          Length = 285

 Score =  131 bits (329), Expect = 3e-29
 Identities = 61/127 (48%), Positives = 93/127 (73%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P S+Y+++K+N  +GLHTL LLDI+VKE + E++ RG +  YEPPR+M+V     Q
Sbjct: 138 ETWKPSSYYDRVKENVQIGLHTLVLLDIKVKEQSLENMARG-RLIYEPPRFMTVAQCAAQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + V+G D+  VG AR+G+EDQ +VAGT+++L  VD G PLH LV++G   H
Sbjct: 197 MLETEEERQEGVWGPDSLAVGAARVGAEDQKLVAGTLQELTQVDMGRPLHSLVLLGRRAH 256

Query: 359 PVEEEML 379
            +E++ +
Sbjct: 257 DLEKDYI 263

[114][TOP]
>UniRef100_Q59NX9 Diphthine synthase n=2 Tax=Candida albicans RepID=DPH5_CANAL
          Length = 299

 Score =  131 bits (329), Expect = 3e-29
 Identities = 65/127 (51%), Positives = 88/127 (69%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 DSWKPDSFYGKIMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATAAQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E    +  Y  +T CV  +RLGS  QT  AGT+++L   D G PLH LV++G + H
Sbjct: 198 LLEIESIRQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYDSGEPLHSLVMLGRQVH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 ELELEYL 264

[115][TOP]
>UniRef100_Q754E7 Diphthine synthase n=1 Tax=Eremothecium gossypii RepID=DPH5_ASHGO
          Length = 298

 Score =  131 bits (329), Expect = 3e-29
 Identities = 67/130 (51%), Positives = 93/130 (71%), Gaps = 2/130 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++WRPDS+Y+K+ +NR +GLHTL LLDI+VKE + E+L RG +  +EPPRYMS++   EQ
Sbjct: 139 DSWRPDSWYDKVLENRRIGLHTLVLLDIKVKEQSPENLARG-RLIFEPPRYMSISQCCEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLEVE+K G   Y  DT CV  +RLG+  Q + +G++ +L   D G PLH LVI+G + H
Sbjct: 198 LLEVEEKRGQQAYTPDTPCVAISRLGAPTQHMKSGSIHELAEYDAGEPLHSLVILGRQCH 257

Query: 359 PVE-EEMLEF 385
            +E E +LEF
Sbjct: 258 ELELEYLLEF 267

[116][TOP]
>UniRef100_C6HBC6 Diphthine synthase n=1 Tax=Ajellomyces capsulatus H143
           RepID=C6HBC6_AJECH
          Length = 285

 Score =  130 bits (328), Expect = 4e-29
 Identities = 62/123 (50%), Positives = 88/123 (71%), Gaps = 1/123 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY ++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 138 ETWKPSSFYNRVKENVQLGFHTLMLLDIKVKEQSLENMARG-RKIYEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E++  + VYG  +  +G AR+G+ DQ +  GT+K+L  VD G PLH LV++G +TH
Sbjct: 197 MLEIEEERKECVYGPTSLAIGAARVGASDQHLAVGTLKELCDVDMGKPLHSLVLLGKKTH 256

Query: 359 PVE 367
            +E
Sbjct: 257 DLE 259

[117][TOP]
>UniRef100_C5MHH3 Diphthine synthase n=1 Tax=Candida tropicalis MYA-3404
           RepID=C5MHH3_CANTT
          Length = 299

 Score =  130 bits (328), Expect = 4e-29
 Identities = 64/127 (50%), Positives = 89/127 (70%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 DSWKPDSFYPKIMENRKIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATACQQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+   +  Y  +T CV  +RLGS  QT  AGT+++L   D G PL+ LV++G + H
Sbjct: 198 LLEIEEARQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELSEYDSGEPLYSLVMLGRQVH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 DLELEYL 264

[118][TOP]
>UniRef100_C5E4E4 Diphthine synthase n=1 Tax=Zygosaccharomyces rouxii CBS 732
           RepID=C5E4E4_ZYGRC
          Length = 300

 Score =  130 bits (328), Expect = 4e-29
 Identities = 67/130 (51%), Positives = 91/130 (70%), Gaps = 2/130 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDS+Y+KI +NR +GLHTL LLDI+VKE + E++ RG +  +EPPRYMS++   EQ
Sbjct: 139 DNWRPDSWYDKIMENRRIGLHTLVLLDIKVKEQSIENMARG-RLIFEPPRYMSISQCCEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+K G   Y  +T  V  +RLGS  Q   AGT+++L   D G PLH LVI+G + H
Sbjct: 198 LLEIEEKRGTKAYTPNTPVVAVSRLGSASQQFKAGTIEELSQYDAGEPLHSLVILGRQCH 257

Query: 359 PVE-EEMLEF 385
            +E E +LEF
Sbjct: 258 ELELEYLLEF 267

[119][TOP]
>UniRef100_UPI000151B383 hypothetical protein PGUG_04761 n=1 Tax=Pichia guilliermondii ATCC
           6260 RepID=UPI000151B383
          Length = 296

 Score =  130 bits (327), Expect = 5e-29
 Identities = 63/128 (49%), Positives = 88/128 (68%), Gaps = 1/128 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+K+ +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYM + TA +Q
Sbjct: 139 ETWKPASFYDKVLENRRIGLHTLLLLDIKVKEQSIENMARG-RLIYEPPRYMDIATAAKQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE+E+  G   Y  D+ CV  +RLG   QT  AGT+ ++   D G PLH LV++G + H
Sbjct: 198 MLEIEELKGQKAYTPDSPCVAISRLGLPTQTFKAGTLAEMAEYDSGEPLHSLVLMGRQVH 257

Query: 359 PVEEEMLE 382
            +E E L+
Sbjct: 258 DLELEYLD 265

[120][TOP]
>UniRef100_A7TJE8 Diphthine synthase n=1 Tax=Vanderwaltozyma polyspora DSM 70294
           RepID=A7TJE8_VANPO
          Length = 300

 Score =  130 bits (327), Expect = 5e-29
 Identities = 67/130 (51%), Positives = 90/130 (69%), Gaps = 2/130 (1%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDS+Y KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYMS++   EQ
Sbjct: 139 DNWRPDSWYGKIMENRRIGLHTLVLLDIKVKEQSIENMARG-RLIYEPPRYMSISQCCEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+  G   Y  DT  V  +RLGS  Q+  +GT+++L   D G PLH LVI+G + H
Sbjct: 198 LLEIEESRGTKAYTPDTPVVAISRLGSAGQSFKSGTIQELSEYDAGEPLHSLVILGRQCH 257

Query: 359 PVE-EEMLEF 385
            +E E +LEF
Sbjct: 258 ELELEYLLEF 267

[121][TOP]
>UniRef100_C1GUI3 Diphthine synthase n=1 Tax=Paracoccidioides brasiliensis Pb01
           RepID=C1GUI3_PARBA
          Length = 285

 Score =  130 bits (326), Expect = 6e-29
 Identities = 62/127 (48%), Positives = 92/127 (72%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P SFY+++K+N  LG HTL LLDI+VKE + E++ RG +K YEPPRYM+V+    Q
Sbjct: 138 EKWKPSSFYDRVKENVQLGFHTLMLLDIKVKEQSIENMERG-RKIYEPPRYMTVSQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGE-TH 358
           +LE+E++  + VYG  +  VG AR+G+ +Q +V GT+K+L  VD G PLH LV++G+ TH
Sbjct: 197 MLEIEEERKEGVYGPASLAVGAARVGAPNQQLVVGTLKELCDVDMGKPLHSLVLLGKRTH 256

Query: 359 PVEEEML 379
            +E + +
Sbjct: 257 DLERDYI 263

[122][TOP]
>UniRef100_Q6MY91 Diphthine synthase n=2 Tax=Aspergillus fumigatus RepID=DPH5_ASPFU
          Length = 285

 Score =  129 bits (325), Expect = 8e-29
 Identities = 60/123 (48%), Positives = 89/123 (72%), Gaps = 1/123 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P S+Y+++K+N  LGLHTL LLDI+VKE ++E++ RG ++ +EPPRYM+V     Q
Sbjct: 138 ENWKPTSYYDRVKENVQLGLHTLVLLDIKVKEQSYENMARG-RRIFEPPRYMTVAQCASQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E++  + V+G D+  VG AR+G  DQ +V GT+K+L  VD G PLH LV++G + H
Sbjct: 197 MLETEEERKEGVFGPDSLAVGAARVGGPDQKLVVGTLKELSEVDMGPPLHSLVLLGRKAH 256

Query: 359 PVE 367
            +E
Sbjct: 257 DLE 259

[123][TOP]
>UniRef100_Q5CXG3 Diphthine synthase (Fragment) n=2 Tax=Cryptosporidium parvum
           RepID=Q5CXG3_CRYPV
          Length = 274

 Score =  129 bits (324), Expect = 1e-28
 Identities = 65/132 (49%), Positives = 88/132 (66%), Gaps = 1/132 (0%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           +W+P SFY+KIK N   GLHTLCLLDI+VKE T E++ R  +  +EPPR+M+VN AI QL
Sbjct: 144 SWQPSSFYDKIKANIERGLHTLCLLDIKVKEQTIENMMRN-RPIFEPPRFMTVNQAISQL 202

Query: 185 LEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETHP 361
             +E K   +V   ++  +G AR+GS DQ IV+GT+ +L   DFG PLH LVI   + H 
Sbjct: 203 FILEDKLKQNVISPNSLAIGVARIGSSDQKIVSGTLSELSDTDFGNPLHSLVICHPDLHL 262

Query: 362 VEEEMLEFYKYK 397
           +E+   E Y+ K
Sbjct: 263 IEQRFFEIYRKK 274

[124][TOP]
>UniRef100_Q5CEV5 Diphthine synthase n=1 Tax=Cryptosporidium hominis
           RepID=Q5CEV5_CRYHO
          Length = 271

 Score =  129 bits (324), Expect = 1e-28
 Identities = 65/132 (49%), Positives = 88/132 (66%), Gaps = 1/132 (0%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           +W+P SFY+KIK N   GLHTLCLLDI+VKE T E++ R  +  +EPPR+M+VN AI QL
Sbjct: 140 SWQPSSFYDKIKANIERGLHTLCLLDIKVKEQTIENMMRN-RPIFEPPRFMTVNQAISQL 198

Query: 185 LEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETHP 361
             +E K   +V   ++  +G AR+GS DQ IV+GT+ +L   DFG PLH LVI   + H 
Sbjct: 199 FILEDKLKQNVISPNSLAIGVARIGSSDQKIVSGTLSELSDTDFGNPLHSLVICHPDLHL 258

Query: 362 VEEEMLEFYKYK 397
           +E+   E Y+ K
Sbjct: 259 IEQRFFEIYRKK 270

[125][TOP]
>UniRef100_UPI00015B5B27 PREDICTED: similar to ENSANGP00000003767 n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B5B27
          Length = 283

 Score =  129 bits (323), Expect = 1e-28
 Identities = 67/135 (49%), Positives = 89/135 (65%), Gaps = 6/135 (4%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDSFY+KI +N   GLHTLCLLDI+VKEPT ES+ +  KK Y PP++MSV  A +Q
Sbjct: 138 ETWKPDSFYDKIIENYQRGLHTLCLLDIKVKEPTLESILK-KKKVYMPPKFMSVAEAADQ 196

Query: 182 LLEV-----EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV 346
           LL++     ++    S     +  VG AR+GS+DQ I   ++ ++  VD G PLHCLVI 
Sbjct: 197 LLQIIENKTKENEDKSSISSSSLAVGLARVGSDDQKIFVCSLSKMSKVDLGPPLHCLVIP 256

Query: 347 GET-HPVEEEMLEFY 388
           G + HP+E E L  Y
Sbjct: 257 GHSLHPLESEYLSQY 271

[126][TOP]
>UniRef100_A0BGB9 Diphthine synthase n=1 Tax=Paramecium tetraurelia
           RepID=A0BGB9_PARTE
          Length = 278

 Score =  128 bits (322), Expect = 2e-28
 Identities = 66/131 (50%), Positives = 87/131 (66%), Gaps = 1/131 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P SFY KIK N    LHTL LLDI+VKE + E+L RG KK YE PR+MS   A+EQ
Sbjct: 142 EKWKPYSFYPKIKANLDHNLHTLVLLDIKVKEISEENLARG-KKIYEAPRFMSTQVAVEQ 200

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           ++E +++ G +   E T+C G AR+G E Q IV+G + +   +D G PLH  VI   E H
Sbjct: 201 IIESDKQLGLNAIDEKTKCFGVARVGFESQKIVSGFLHEFLEIDMGLPLHSFVICAKELH 260

Query: 359 PVEEEMLEFYK 391
           P+EEEM +FY+
Sbjct: 261 PIEEEMFQFYR 271

[127][TOP]
>UniRef100_C5E3A7 Diphthine synthase n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5E3A7_LACTC
          Length = 299

 Score =  128 bits (321), Expect = 2e-28
 Identities = 65/127 (51%), Positives = 86/127 (67%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDS+Y KI +NR +GLHTL LLDI+VKE + E++ RG +  YEPPRYMS++   EQ
Sbjct: 139 DDWRPDSWYNKIWENRKIGLHTLVLLDIKVKEQSIENMARG-RLIYEPPRYMSISQCCEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+  G   Y  DT  V  +RLGS  Q   +GT+++L   D G PLH LVI+G + H
Sbjct: 198 LLEIEETRGTKAYTPDTPVVAISRLGSASQEFKSGTIEELSRYDAGEPLHSLVILGRQCH 257

Query: 359 PVEEEML 379
            +E E L
Sbjct: 258 ELELEYL 264

[128][TOP]
>UniRef100_B0DXX9 Diphthine synthase n=1 Tax=Laccaria bicolor S238N-H82
           RepID=B0DXX9_LACBS
          Length = 292

 Score =  128 bits (321), Expect = 2e-28
 Identities = 70/139 (50%), Positives = 96/139 (69%), Gaps = 7/139 (5%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+PDSFY++IK+N  LG+HTL LLDI+VKE + E+L R G+K YEPPRYMS++TA+ Q
Sbjct: 138 DTWKPDSFYDRIKENVKLGMHTLVLLDIKVKEQSEENLAR-GRKIYEPPRYMSIHTAVSQ 196

Query: 182 LLEVEQKHGDSVYGE-DTQCVGFARL--GSEDQTIVAGTMKQLE---SVDFGAPLHCLVI 343
           LLE E    + +    DT  +  +R+  GSE++ IVAGT+++L    S  FG PLH LVI
Sbjct: 197 LLETEASRNEGILSSTDTLAIALSRVGGGSENERIVAGTLQELRDHPSAAFGEPLHSLVI 256

Query: 344 VGE-THPVEEEMLEFYKYK 397
           VG+  H +E +  E Y  K
Sbjct: 257 VGKRLHHLEVDYAETYAIK 275

[129][TOP]
>UniRef100_UPI0001925B41 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001925B41
          Length = 282

 Score =  127 bits (320), Expect = 3e-28
 Identities = 63/135 (46%), Positives = 87/135 (64%), Gaps = 6/135 (4%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + WRPDSFY+KI  N+   LHTLCLLDI+VKE + E++ R GK ++EPP +++ N  + Q
Sbjct: 138 DNWRPDSFYDKIIANKERKLHTLCLLDIKVKEQSIENMMR-GKTKFEPPPFLTANEPLNQ 196

Query: 182 LLEVEQK------HGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI 343
           LLEV  K          V  + + CV  AR+G EDQ IV GTM ++  +D G P+H L+I
Sbjct: 197 LLEVTNKKRLKKNKKKQVLDDSSFCVALARVGWEDQKIVFGTMNEVSKIDLGPPIHSLII 256

Query: 344 VGETHPVEEEMLEFY 388
            GE H +E EML+ +
Sbjct: 257 PGEIHYIENEMLQLF 271

[130][TOP]
>UniRef100_A7EWW9 Diphthine synthase n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70
           RepID=A7EWW9_SCLS1
          Length = 291

 Score =  127 bits (318), Expect = 5e-28
 Identities = 64/131 (48%), Positives = 95/131 (72%), Gaps = 7/131 (5%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P SFY++I++NR++GLHTL LLDI+VKE + E++ R G+K YEPPRYM+V     Q
Sbjct: 138 ENWKPASFYDRIRENRNIGLHTLVLLDIKVKEQSMENMAR-GRKIYEPPRYMTVGQCASQ 196

Query: 182 LLEVEQ---KHGD-SVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVD--FGAPLHCLVI 343
           +LE+E+   ++G+  VY E++ C+G AR+G +D+  V+GT+KQL   D   G PLH LV+
Sbjct: 197 MLEIEEIKTENGEGGVYNEESLCIGAARVGCKDEKFVSGTLKQLCDADEQLGGPLHSLVL 256

Query: 344 VG-ETHPVEEE 373
           +G  TH +E +
Sbjct: 257 LGRRTHELEHD 267

[131][TOP]
>UniRef100_UPI00005210A7 PREDICTED: similar to GekBS016P n=1 Tax=Ciona intestinalis
           RepID=UPI00005210A7
          Length = 275

 Score =  126 bits (316), Expect = 9e-28
 Identities = 64/131 (48%), Positives = 89/131 (67%), Gaps = 4/131 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P SF +KI +N   G+HTLCLLDI+VKE + E+L R GKK YEPPRYM+ N A +Q
Sbjct: 139 DTWKPSSFCDKINENLKRGMHTLCLLDIKVKEQSIENLMR-GKKVYEPPRYMTSNLACQQ 197

Query: 182 LLEV----EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLEV    + +  +SV  ++T CV  A +GS++Q IVA  + QL + + G  LH L+I G
Sbjct: 198 LLEVVEDKQSESENSVLTKETMCVSLACVGSDEQKIVAAPLNQLVNCELGPVLHSLIITG 257

Query: 350 ETHPVEEEMLE 382
             HP+E + L+
Sbjct: 258 TLHPLEYDFLK 268

[132][TOP]
>UniRef100_A0EH83 Diphthine synthase n=1 Tax=Paramecium tetraurelia
           RepID=A0EH83_PARTE
          Length = 278

 Score =  126 bits (316), Expect = 9e-28
 Identities = 65/131 (49%), Positives = 87/131 (66%), Gaps = 1/131 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P SFY KIK N    LHTL LLDI+VKE + E+L RG KK YE PR+MS   A+EQ
Sbjct: 142 EKWKPYSFYPKIKANLDHNLHTLVLLDIKVKEISEENLARG-KKIYEAPRFMSTQIAVEQ 200

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           ++E +++ G +   E T+C G AR+G E Q IV+G + +   ++ G PLH  VI   E H
Sbjct: 201 IIESDKQLGLNAIDEKTKCFGVARVGFETQKIVSGFLHEFLDIEMGPPLHSFVICAKELH 260

Query: 359 PVEEEMLEFYK 391
           P+EEEM +FY+
Sbjct: 261 PIEEEMFQFYR 271

[133][TOP]
>UniRef100_Q7QA67 Diphthine synthase n=1 Tax=Anopheles gambiae RepID=Q7QA67_ANOGA
          Length = 286

 Score =  125 bits (315), Expect = 1e-27
 Identities = 66/140 (47%), Positives = 93/140 (66%), Gaps = 13/140 (9%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY+KI  N   GLHTLCLLDI+VKEPT ESL +  K++Y PPR+MSV+ A +Q
Sbjct: 138 DSWKPDSFYDKIVANLKHGLHTLCLLDIKVKEPTLESLMK-KKREYMPPRFMSVSEAADQ 196

Query: 182 LLEVEQKHGDSVYG------------EDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAP 325
           LL++  K  D+  G            E+T  VG AR+G + Q I+A ++ ++ +VD G P
Sbjct: 197 LLQIVAKKSDAEAGVQPDQQNEHGLSENTLIVGLARVGHDTQQILACSLSEMRNVDLGPP 256

Query: 326 LHCLVIV-GETHPVEEEMLE 382
           LH L+I  G+ HP+E E L+
Sbjct: 257 LHSLIIPNGQLHPLEMEFLQ 276

[134][TOP]
>UniRef100_Q6C1E0 Diphthine synthase n=1 Tax=Yarrowia lipolytica RepID=DPH5_YARLI
          Length = 300

 Score =  125 bits (315), Expect = 1e-27
 Identities = 60/127 (47%), Positives = 87/127 (68%), Gaps = 1/127 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSFY+KI +NR +GLHTL LLDI+VKE + E++ RG +  +EPPRYMS+  A  Q
Sbjct: 139 DSWKPDSFYDKIHENRKIGLHTLVLLDIKVKEQSIENIMRG-RNVFEPPRYMSIEQAASQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LLE+E+   + VY  DT  +  +RLGS  Q I AG++ +L   + G PLH L+++G   H
Sbjct: 198 LLEIEESRDEKVYCSDTPAIAVSRLGSPRQCIKAGSLGELAEYESGEPLHSLIVLGNNVH 257

Query: 359 PVEEEML 379
            +E + L
Sbjct: 258 DLEIDFL 264

[135][TOP]
>UniRef100_Q17514 Diphthine synthase n=1 Tax=Caenorhabditis elegans
           RepID=Q17514_CAEEL
          Length = 274

 Score =  125 bits (314), Expect = 1e-27
 Identities = 61/134 (45%), Positives = 89/134 (66%), Gaps = 4/134 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+P+S+Y+KI  NR  G+HTLCLLDI+ KE T E++ RG +K +EP RY   + A  Q
Sbjct: 141 DEWQPESYYDKIALNRKRGMHTLCLLDIKTKEQTVENMMRG-RKIFEPARYQKCSEAARQ 199

Query: 182 LLEVEQ----KHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LL + +    K  +  Y E+T  VG AR+G ++Q IV  +MK +  ++ G PLH L+I G
Sbjct: 200 LLTIYERRKAKGEECAYDENTMVVGLARVGWDNQKIVYASMKDMSEMEMGEPLHSLIIPG 259

Query: 350 ETHPVEEEMLEFYK 391
           ETHP+E +MLE ++
Sbjct: 260 ETHPLEVDMLETFR 273

[136][TOP]
>UniRef100_Q4HZI0 Diphthine synthase n=1 Tax=Gibberella zeae RepID=DPH5_GIBZE
          Length = 287

 Score =  125 bits (313), Expect = 2e-27
 Identities = 60/125 (48%), Positives = 90/125 (72%), Gaps = 3/125 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P SFY++IK+NR +GLHTL L+DI+VKE + E++ RG +  YEPPRYM+V    +Q
Sbjct: 138 DTWKPASFYDRIKENRQIGLHTLVLVDIKVKEQSLENMARG-RLVYEPPRYMTVGQCAQQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVD--FGAPLHCLVIVG-E 352
           +LE+E++  + VY +D+  +G AR+G   +  VAGT+++L S D   G PLH LV++G  
Sbjct: 197 MLEIEEERKEGVYAKDSLAIGAARVGGRTEKFVAGTLEELCSTDEELGPPLHSLVLLGRR 256

Query: 353 THPVE 367
           TH +E
Sbjct: 257 THELE 261

[137][TOP]
>UniRef100_B3L3M9 Diphthine synthase n=1 Tax=Plasmodium knowlesi strain H
           RepID=B3L3M9_PLAKH
          Length = 270

 Score =  124 bits (311), Expect = 3e-27
 Identities = 63/133 (47%), Positives = 87/133 (65%), Gaps = 1/133 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ET++P SFY+KIK N     HTLCLLDI+VKE T E+L +  K  YEPPRYM++N AIEQ
Sbjct: 139 ETYKPTSFYDKIKVNLDNNFHTLCLLDIKVKERTIENLMKN-KNIYEPPRYMTINEAIEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET-H 358
           LL  E+ H  +V  ++T+ +   R+GS  Q IV+G +  L+++ +  PLH L+I   T H
Sbjct: 198 LLYCEEVHKKNVITDNTRGIAIVRIGSNSQQIVSGNLLTLKTIKYNDPLHSLIICAPTLH 257

Query: 359 PVEEEMLEFYKYK 397
            VE E  + Y +K
Sbjct: 258 DVEREYFDMYMHK 270

[138][TOP]
>UniRef100_C5FC61 Diphthine synthase n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FC61_NANOT
          Length = 292

 Score =  124 bits (311), Expect = 3e-27
 Identities = 57/125 (45%), Positives = 88/125 (70%), Gaps = 1/125 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P S+Y++IK+N   GLHTL LLDI+VKE + E++ RG +K YEPPRYM+V     Q
Sbjct: 145 DTWKPSSYYDRIKQNAEHGLHTLVLLDIKVKEQSLENMARG-RKIYEPPRYMTVAQCAAQ 203

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           +LE E +  + + G ++  +G AR+G+ DQ +  GT+++L  +D G PLH LV++G +TH
Sbjct: 204 MLETEAERQEGICGPESLAIGAARVGAVDQQLAVGTLEELSKIDMGKPLHSLVLLGKKTH 263

Query: 359 PVEEE 373
            +E +
Sbjct: 264 ELERD 268

[139][TOP]
>UniRef100_A7AVR3 Diphthine synthase n=1 Tax=Babesia bovis RepID=A7AVR3_BABBO
          Length = 268

 Score =  124 bits (310), Expect = 4e-27
 Identities = 62/129 (48%), Positives = 86/129 (66%), Gaps = 1/129 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W PDSFY+KI KN    LHTLCLLDI+V+E + E+L    +  +EPPRYMSVN AI+Q+ 
Sbjct: 142 WSPDSFYDKIVKNMEANLHTLCLLDIKVRERSIENL-MNNRMIFEPPRYMSVNIAIDQIF 200

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETHPV 364
            ++  H       +T+ +G ARLGS+   I AGT+K+L+ +DFG PLH +VI   + H +
Sbjct: 201 RID--HTKHRLPSNTRAIGVARLGSKTAKIAAGTLKELKDIDFGEPLHSMVICAPQLHDI 258

Query: 365 EEEMLEFYK 391
           EEE  + Y+
Sbjct: 259 EEEYFKHYR 267

[140][TOP]
>UniRef100_B6ADU6 Diphthine synthase n=1 Tax=Cryptosporidium muris RN66
           RepID=B6ADU6_9CRYT
          Length = 280

 Score =  123 bits (309), Expect = 6e-27
 Identities = 62/126 (49%), Positives = 88/126 (69%), Gaps = 1/126 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W+P+SFY+K+K N   GLHTLCLLDI+VKE + +++ R     +E PRYM++N AI+QL 
Sbjct: 141 WQPESFYDKVKLNMKQGLHTLCLLDIKVKEQSLDNMMRN-LPIFESPRYMNINQAIKQLY 199

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETHPV 364
            +E+K  + V    T   G AR+GS++Q I+AGT++QL SVDFG PLH LV+   E H +
Sbjct: 200 IIEKKRNERVALPSTLAFGVARIGSKNQLILAGTLEQLSSVDFGEPLHSLVLCHPELHLI 259

Query: 365 EEEMLE 382
           E++  E
Sbjct: 260 EKKFFE 265

[141][TOP]
>UniRef100_C7Z4T6 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
           RepID=C7Z4T6_NECH7
          Length = 286

 Score =  123 bits (308), Expect = 7e-27
 Identities = 60/127 (47%), Positives = 90/127 (70%), Gaps = 3/127 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+P SFY++IK+NR +GLHTL L+DI+VKE + E++ RG +  YEPPRYM+V    +Q
Sbjct: 138 DTWKPASFYDRIKENREIGLHTLVLVDIKVKEQSLENMARG-RLIYEPPRYMTVGQCAQQ 196

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESV--DFGAPLHCLVIVG-E 352
           +LE+E +  + VY +D+  +G AR+G   +  VAGT+++L S   D G PLH LV++G  
Sbjct: 197 MLEIEDERKEGVYTKDSLAIGAARVGGVTEKFVAGTLEELCSTDEDLGPPLHSLVLLGRR 256

Query: 353 THPVEEE 373
           TH +E +
Sbjct: 257 THELEHD 263

[142][TOP]
>UniRef100_A4QXG9 Diphthine synthase n=1 Tax=Magnaporthe grisea RepID=A4QXG9_MAGGR
          Length = 293

 Score =  123 bits (308), Expect = 7e-27
 Identities = 68/135 (50%), Positives = 93/135 (68%), Gaps = 9/135 (6%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRP SFY+++ +NR+LGLHTL LLDI+VKEP FESL R GK  YEPPR+M+V T   Q
Sbjct: 138 ENWRPSSFYDRVAENRALGLHTLVLLDIKVKEPNFESLAR-GKLVYEPPRFMTVGTCARQ 196

Query: 182 LLEVEQ---KHG--DSVYGEDTQCVGFARLGSEDQTIVAGTMKQL-ESVD--FGAPLHCL 337
           +LEVE+   K G    V G +   +G AR+G + +  VAGT+++L +  D   GAPLH L
Sbjct: 197 MLEVEEEKVKDGAEGGVCGGEALAIGAARVGGKTEKFVAGTLRELADGADELLGAPLHSL 256

Query: 338 VIVG-ETHPVEEEML 379
           V++G +TH +E + +
Sbjct: 257 VLLGKKTHELEHDFV 271

[143][TOP]
>UniRef100_UPI00017582BF PREDICTED: similar to Diphthamide methyltransferase CG31289-PA n=1
           Tax=Tribolium castaneum RepID=UPI00017582BF
          Length = 273

 Score =  122 bits (306), Expect = 1e-26
 Identities = 64/134 (47%), Positives = 94/134 (70%), Gaps = 4/134 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TW+PDSF++K++ N    LHTLCLLDI+VKEPT ESL +  KK++ PPR+MSV  A +Q
Sbjct: 138 KTWQPDSFFDKVELNYRNKLHTLCLLDIKVKEPTLESLTK-KKKEFMPPRFMSVAEAAQQ 196

Query: 182 LLEV--EQKHGDSVYGEDTQ-CVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG- 349
           L ++  ++K  D++       CVG AR+GS+ Q I+A +++Q+ S+D G PLH L+I   
Sbjct: 197 LAQILEKRKSEDNILVSGASLCVGLARVGSKTQKIIACSLQQMCSIDIGGPLHSLIITSP 256

Query: 350 ETHPVEEEMLEFYK 391
           E HP+E E LE ++
Sbjct: 257 ELHPLEVEYLEQFR 270

[144][TOP]
>UniRef100_C1BVA9 Diphthine synthase n=1 Tax=Lepeophtheirus salmonis
           RepID=C1BVA9_9MAXI
          Length = 270

 Score =  122 bits (306), Expect = 1e-26
 Identities = 57/127 (44%), Positives = 84/127 (66%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           WRP SF+++I  N   GLHTLCLLDI+VKE + E++ +  +  YEPPR+MSVN A +QLL
Sbjct: 141 WRPTSFFDRIVDNFERGLHTLCLLDIKVKEKSVENIIKN-RNIYEPPRFMSVNVAAQQLL 199

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           ++ Q          TQC+   R+G+  Q  +  T++Q++ VD G PLH LV++G+ + VE
Sbjct: 200 DIVQSRDSKDITSQTQCIAAVRVGTPSQRFLTCTLEQMKEVDMGGPLHSLVVIGKMNAVE 259

Query: 368 EEMLEFY 388
           EE L+ +
Sbjct: 260 EESLKCF 266

[145][TOP]
>UniRef100_A8WT81 Diphthine synthase n=2 Tax=Caenorhabditis briggsae
           RepID=A8WT81_CAEBR
          Length = 276

 Score =  122 bits (306), Expect = 1e-26
 Identities = 60/137 (43%), Positives = 90/137 (65%), Gaps = 4/137 (2%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W+P+S+Y+KI  NR  G+HTLCLLDI+ KE T E++ RG +K +EP RY   + A  Q
Sbjct: 141 DEWQPESYYDKIALNRQRGMHTLCLLDIKTKEQTVENMMRG-RKIFEPARYQKCSEAASQ 199

Query: 182 LLEV----EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LL +    + K  +  Y E+T  VG AR+G ++Q IV  ++ ++  ++ G PLH L+I G
Sbjct: 200 LLTICERRKAKGEECAYDENTMVVGLARVGWDNQKIVYCSLTEMSEMEMGEPLHSLIIPG 259

Query: 350 ETHPVEEEMLEFYKYKS 400
           ETHP+E +MLE ++  S
Sbjct: 260 ETHPLEVDMLETFRASS 276

[146][TOP]
>UniRef100_Q17H41 Diphthine synthase n=1 Tax=Aedes aegypti RepID=Q17H41_AEDAE
          Length = 306

 Score =  122 bits (305), Expect = 2e-26
 Identities = 64/133 (48%), Positives = 87/133 (65%), Gaps = 8/133 (6%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W+PDSF++KI  N   GLHTLCLLDIRVKEPT  SL +  K++YEPPR+MS +TA +QL 
Sbjct: 140 WQPDSFFDKIILNLEHGLHTLCLLDIRVKEPTLASLTK-KKREYEPPRFMSCSTACDQLA 198

Query: 188 EV--------EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI 343
           ++        E KH   ++ +    +G AR+G E Q I A T+K+++  D G PLH L+I
Sbjct: 199 QLIHKRRLSGEAKH--HLFNDRNVVIGLARVGHETQEIKACTLKEMKQTDLGEPLHSLII 256

Query: 344 VGETHPVEEEMLE 382
             E HP+E E L+
Sbjct: 257 PAEMHPMEIEFLQ 269

[147][TOP]
>UniRef100_A8N4V0 Diphthine synthase n=1 Tax=Coprinopsis cinerea okayama7#130
           RepID=A8N4V0_COPC7
          Length = 292

 Score =  120 bits (300), Expect = 6e-26
 Identities = 65/136 (47%), Positives = 93/136 (68%), Gaps = 7/136 (5%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+PDS+Y+++K+N  LG+HTL LLDI+VKE + E+L R G+K YEPPRYMS+ TA+ Q
Sbjct: 138 ETWKPDSYYDRVKENVQLGMHTLVLLDIKVKEQSEENLAR-GRKIYEPPRYMSIPTAVSQ 196

Query: 182 LLEVEQKHGDSVYG-EDTQCVGFARLGSE--DQTIVAGTMKQLESVD---FGAPLHCLVI 343
           +L+ E    ++V   E T  +  +R+G +   Q IVAGT+K+L+      FG PLH +VI
Sbjct: 197 MLDTESTRQENVLNPESTLAIALSRVGGDGNQQRIVAGTLKELQGQPPEVFGEPLHSIVI 256

Query: 344 VGE-THPVEEEMLEFY 388
           VG+  H +E E  E +
Sbjct: 257 VGKRVHYLEIEYAEAF 272

[148][TOP]
>UniRef100_A8NVL7 Diphthine synthase n=1 Tax=Brugia malayi RepID=A8NVL7_BRUMA
          Length = 276

 Score =  119 bits (299), Expect = 8e-26
 Identities = 59/133 (44%), Positives = 89/133 (66%), Gaps = 4/133 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W PDS+Y KI +N+  GLHTLCLLDI+ KE + +++ + G+K++ PPRYM+ + A +Q
Sbjct: 140 ENWHPDSYYFKIAENKKRGLHTLCLLDIKTKEQSIKNMMK-GRKEFLPPRYMTCSDAAKQ 198

Query: 182 LLEVEQKHGDS----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LLE+  +  D     VY + T+ V  AR+G +DQ IV  +++ L  +D G PLH L+I G
Sbjct: 199 LLEIVDQMSDENMEPVYTKSTEVVALARVGWDDQKIVFCSLEALCDLDMGPPLHSLIIPG 258

Query: 350 ETHPVEEEMLEFY 388
           E HP+E + L+ +
Sbjct: 259 ELHPMELDFLKSF 271

[149][TOP]
>UniRef100_UPI00003C0AFF PREDICTED: similar to Diphthamide methyltransferase CG31289-PA n=1
           Tax=Apis mellifera RepID=UPI00003C0AFF
          Length = 275

 Score =  116 bits (291), Expect = 7e-25
 Identities = 59/137 (43%), Positives = 89/137 (64%), Gaps = 7/137 (5%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W+P+SFY+KI  NR   LHTLCLLDI++KEPT ES+ +  K++Y P R+MSV+ A+ QLL
Sbjct: 140 WQPNSFYDKIISNRRRDLHTLCLLDIKIKEPTIESISK-KKREYMPTRFMSVSEAVTQLL 198

Query: 188 EV------EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI-V 346
           ++      E K    +  + +  +G AR+G ++Q IVA +++++ S D G PLH L+I  
Sbjct: 199 KIMEEKMEENKEEMVLLNKSSLAIGLARIGWDNQRIVACSLEKMASTDLGPPLHSLIIPA 258

Query: 347 GETHPVEEEMLEFYKYK 397
              HP+E E +  Y Y+
Sbjct: 259 TNLHPLESEFMSLYMYE 275

[150][TOP]
>UniRef100_A5K7B4 Diphthine synthase n=1 Tax=Plasmodium vivax RepID=A5K7B4_PLAVI
          Length = 271

 Score =  115 bits (287), Expect = 2e-24
 Identities = 60/131 (45%), Positives = 86/131 (65%), Gaps = 1/131 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           ++P SFY+KIK N     HTLCLLDI+VKE T E++ +  K  YEP R+M+VN AIEQLL
Sbjct: 141 YKPTSFYDKIKVNLDNNFHTLCLLDIKVKERTIENMMKN-KNIYEPSRFMTVNEAIEQLL 199

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET-HPV 364
             E+    +V  ++T+ +   R+GS+ Q IV+G++  L+SV +  PLH L+I   T H V
Sbjct: 200 YCEEVLKKNVITDNTRGIAIVRIGSDSQQIVSGSLLALKSVSYNDPLHSLIICAPTLHDV 259

Query: 365 EEEMLEFYKYK 397
           E E  E Y+++
Sbjct: 260 EREYFEMYQHR 270

[151][TOP]
>UniRef100_C5L9M9 Putative uncharacterized protein (Fragment) n=1 Tax=Perkinsus
           marinus ATCC 50983 RepID=C5L9M9_9ALVE
          Length = 226

 Score =  114 bits (286), Expect = 3e-24
 Identities = 58/122 (47%), Positives = 85/122 (69%), Gaps = 5/122 (4%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDS+++KI  N   GLHTLCLLDI+VKE +  +L + G + YEPPR+MSV TA+EQ
Sbjct: 92  DSWKPDSYFDKIADNAKRGLHTLCLLDIKVKEQSVVNLMK-GNEIYEPPRFMSVQTALEQ 150

Query: 182 LLEVEQKHGD-SVYGEDTQCVGFARLGSEDQTIVAGTMKQL----ESVDFGAPLHCLVIV 346
           L+E+++K G+  + G+D+  VG AR+G +DQ+IV G  + +     S   G PLH LVI 
Sbjct: 151 LMEIDEKRGNPGIVGKDSLVVGVARVGCKDQSIVFGRAEDVASEKASEKLGGPLHSLVIC 210

Query: 347 GE 352
            +
Sbjct: 211 AQ 212

[152][TOP]
>UniRef100_C5K8E6 Diphthine synthase n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5K8E6_9ALVE
          Length = 281

 Score =  114 bits (286), Expect = 3e-24
 Identities = 60/139 (43%), Positives = 91/139 (65%), Gaps = 9/139 (6%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDS+++KI  N   GLHTLCLLDI+VKE +  +L + G + YEPPR+MSV TA+EQ
Sbjct: 143 DSWKPDSYFDKIADNAKRGLHTLCLLDIKVKEQSVVNLMK-GNEIYEPPRFMSVQTALEQ 201

Query: 182 LLEVEQKHGD-SVYGEDTQCVGFARLGSEDQTIVAGTMKQL----ESVDFGAPLHCLVIV 346
           L+E+++  G   + G+D+  VG AR+G ++Q+IV G  + +     S   G PLH LV+ 
Sbjct: 202 LMEIDENRGSPGIVGKDSLVVGVARVGCQNQSIVFGRAEDVASDKASEKLGGPLHSLVVC 261

Query: 347 GE----THPVEEEMLEFYK 391
            +       +EEE +E Y+
Sbjct: 262 AQGMEGLQEMEEEFVEQYR 280

[153][TOP]
>UniRef100_B0WNF9 Diphthine synthase n=1 Tax=Culex quinquefasciatus
           RepID=B0WNF9_CULQU
          Length = 301

 Score =  114 bits (286), Expect = 3e-24
 Identities = 60/133 (45%), Positives = 87/133 (65%), Gaps = 6/133 (4%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDSF++K+  N   G HTLCLLDIRVKEPT ESL +   +QY+PPR+MS + A +Q
Sbjct: 138 DSWQPDSFFDKVLANADRGSHTLCLLDIRVKEPTLESLTK-KIRQYQPPRFMSCSEAADQ 196

Query: 182 LLEVEQKHGDS-----VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI- 343
           LL++  +  +S        + +  VG AR+G E Q I A T++++  +D G PLH L+I 
Sbjct: 197 LLKIVHRRRESGESSCRLSDRSIVVGLARVGHETQVIKACTLREMHQLDLGPPLHSLIIP 256

Query: 344 VGETHPVEEEMLE 382
             E HP+E E L+
Sbjct: 257 APEMHPLEVEYLQ 269

[154][TOP]
>UniRef100_Q4YT00 Diphthine synthase n=1 Tax=Plasmodium berghei RepID=Q4YT00_PLABE
          Length = 274

 Score =  112 bits (279), Expect = 2e-23
 Identities = 55/128 (42%), Positives = 82/128 (64%), Gaps = 1/128 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           ++P S+Y KIK N     HTLCLLDI+VKE T E++ +  K  YEPP++M+VN AIEQL+
Sbjct: 141 YKPTSYYNKIKINLDNNFHTLCLLDIKVKERTIENIMKN-KNIYEPPKFMTVNEAIEQLI 199

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETHPV 364
             E  H ++V  ++T  +   R+GS DQ IV+G +  L++ ++  PLH L+I     H +
Sbjct: 200 YCESVHNENVITKNTLAIAIVRIGSNDQQIVSGNLFTLKTQEYNDPLHSLIICAPNLHDI 259

Query: 365 EEEMLEFY 388
           E+E  + Y
Sbjct: 260 EKEYFDMY 267

[155][TOP]
>UniRef100_C5LLC3 Diphthine synthase n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5LLC3_9ALVE
          Length = 281

 Score =  111 bits (278), Expect = 2e-23
 Identities = 59/139 (42%), Positives = 90/139 (64%), Gaps = 9/139 (6%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++W+PDS+++KI  N   GLHTLCLLDI+VKE +  +L + G + YEPPR+MSV TA+EQ
Sbjct: 143 DSWKPDSYFDKIADNAKRGLHTLCLLDIKVKEQSVVNLMK-GNEIYEPPRFMSVQTALEQ 201

Query: 182 LLEVEQKHGD-SVYGEDTQCVGFARLGSEDQTIVAGTMKQL----ESVDFGAPLHCLVIV 346
           L+E+++  G   + G+D+  VG AR+  ++Q+IV G  + +     S   G PLH LV+ 
Sbjct: 202 LMEIDEDRGSPGIVGKDSLVVGVARVDCQNQSIVFGRAEDVASDKASEKLGGPLHSLVVC 261

Query: 347 GE----THPVEEEMLEFYK 391
            +       +EEE +E Y+
Sbjct: 262 AQGMEGLQEMEEEFVEQYR 280

[156][TOP]
>UniRef100_Q8IJV5 Diphthine synthase n=1 Tax=Plasmodium falciparum 3D7
           RepID=Q8IJV5_PLAF7
          Length = 274

 Score =  111 bits (277), Expect = 3e-23
 Identities = 53/134 (39%), Positives = 86/134 (64%), Gaps = 1/134 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + ++P S+Y+KI  N     HTLCLLDI+VKE T E++ R  KK YEPPR+M++N +IEQ
Sbjct: 139 DNYKPTSYYDKIYINLKNNFHTLCLLDIKVKERTVENIMRN-KKIYEPPRFMTINDSIEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET-H 358
           LL  E  H  ++  ++T  +   ++G+++Q I++G +  L+ + +  PLH L+I   T H
Sbjct: 198 LLYCEHIHKKNIITKNTLGIAIIQIGTDNQQIISGDLLTLKDISYNKPLHSLIICAPTLH 257

Query: 359 PVEEEMLEFYKYKS 400
            +E+E  + Y Y +
Sbjct: 258 DIEKEYFDLYHYNN 271

[157][TOP]
>UniRef100_Q7RP98 Diphthine synthase n=1 Tax=Plasmodium yoelii yoelii
           RepID=Q7RP98_PLAYO
          Length = 274

 Score =  111 bits (277), Expect = 3e-23
 Identities = 55/128 (42%), Positives = 82/128 (64%), Gaps = 1/128 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           ++P S+Y KIK N     HTLCLLDI+VKE T E++ +  K  YEPP++M+VN AIEQL+
Sbjct: 141 YKPTSYYNKIKINLDNNFHTLCLLDIKVKERTIENIMKN-KNIYEPPKFMTVNEAIEQLI 199

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETHPV 364
             E  H ++V  ++T  +   R+GS+DQ IV+G +  L++  +  PLH L+I     H +
Sbjct: 200 YCESVHNENVITKNTLAIAIVRIGSKDQQIVSGNLFTLKTQKYNDPLHSLIICAPNLHDI 259

Query: 365 EEEMLEFY 388
           E+E  + Y
Sbjct: 260 EKEYFDMY 267

[158][TOP]
>UniRef100_Q4X4K9 Diphthine synthase n=1 Tax=Plasmodium chabaudi RepID=Q4X4K9_PLACH
          Length = 274

 Score =  109 bits (273), Expect = 8e-23
 Identities = 55/128 (42%), Positives = 81/128 (63%), Gaps = 1/128 (0%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           ++P S+Y KIK N     HTLCLLDI+VKE T E++ +  K  YEPP++M+VN AIEQL+
Sbjct: 141 YKPTSYYNKIKINLDNNFHTLCLLDIKVKERTIENIMKN-KNIYEPPKFMTVNEAIEQLI 199

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETHPV 364
             E  H  +V  ++T  +   R+GS+DQ IV+G +  L++  +  PLH L+I     H +
Sbjct: 200 YCETVHNQNVITKNTLAIAIVRIGSKDQQIVSGNIFTLKTQKYNDPLHSLIICAPNLHDI 259

Query: 365 EEEMLEFY 388
           E+E  + Y
Sbjct: 260 EKEYFDMY 267

[159][TOP]
>UniRef100_B8P947 Diphthine synthase n=1 Tax=Postia placenta Mad-698-R
           RepID=B8P947_POSPM
          Length = 290

 Score =  109 bits (273), Expect = 8e-23
 Identities = 64/134 (47%), Positives = 90/134 (67%), Gaps = 6/134 (4%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           TW+PDSFY++I +N +LG+HTL LLDI+VKE + E+L R   K YEPPRYMS+  A+ QL
Sbjct: 139 TWKPDSFYDRIAENTNLGMHTLVLLDIKVKEQSEENLAR---KIYEPPRYMSIPQAVSQL 195

Query: 185 LEVEQKHGDSV-YGEDTQCVGFARL-GSEDQTIVAGTMKQL--ESVD-FGAPLHCLVIVG 349
           +EVE+     V +  +T  +  +R+ G ++Q IV GT+ +L  +  D +G PLH LVIVG
Sbjct: 196 VEVEESRQTGVLHPANTLAMALSRVGGGDEQRIVCGTLDELLAQPADIYGEPLHSLVIVG 255

Query: 350 E-THPVEEEMLEFY 388
           +  H +E E  E Y
Sbjct: 256 KRLHHLEVEYAEAY 269

[160][TOP]
>UniRef100_Q4N836 Diphthine synthase n=1 Tax=Theileria parva RepID=Q4N836_THEPA
          Length = 268

 Score =  104 bits (260), Expect = 3e-21
 Identities = 60/130 (46%), Positives = 81/130 (62%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P SFY+KI +N +  LHTLCLLDI+V+E + E++ +  K  +E PR+MS+N AIEQ
Sbjct: 139 ENWKPFSFYDKIMQNYNNNLHTLCLLDIKVRERSVENIMK-NKLIFEEPRFMSINKAIEQ 197

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG-ETH 358
           LL V Q +  +    D   +G ARL S+DQ I +G ++ L + DFG PLH LVI     H
Sbjct: 198 LLYV-QSNNTTHSKIDFMVIGMARLCSKDQVIKSGKLQDLLNFDFGPPLHSLVICSPHLH 256

Query: 359 PVEEEMLEFY 388
             EE     Y
Sbjct: 257 HYEELFFNHY 266

[161][TOP]
>UniRef100_C7P5Q4 Diphthine synthase n=1 Tax=Methanocaldococcus fervens AG86
           RepID=C7P5Q4_METFA
          Length = 257

 Score = 95.5 bits (236), Expect = 2e-18
 Identities = 52/128 (40%), Positives = 75/128 (58%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E + P++ Y  IK+N   GLHTLCLLDIRV E                 R+M+ N  ++ 
Sbjct: 139 ENYFPETPYNIIKENLERGLHTLCLLDIRVDE--------------NEKRFMTANEGLKV 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+E +  ++V  EDT+ V  AR GS    +V G +K L + DFG PLHC++I G+ H 
Sbjct: 185 LLELENRKKENVISEDTKAVVVARAGSLKPKLVYGKIKYLINYDFGKPLHCIIIPGKLHF 244

Query: 362 VEEEMLEF 385
           +EE+ L++
Sbjct: 245 MEEDALKY 252

[162][TOP]
>UniRef100_Q58670 Probable diphthine synthase n=1 Tax=Methanocaldococcus jannaschii
           RepID=DPHB_METJA
          Length = 257

 Score = 95.1 bits (235), Expect = 2e-18
 Identities = 50/128 (39%), Positives = 74/128 (57%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E + P++ Y  IK+N   GLHTLCLLDIR+ E                 R+M+ N  ++ 
Sbjct: 139 ENYFPETPYNVIKENLERGLHTLCLLDIRIDE--------------NEKRFMTANEGLKV 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+E +  + +  EDT+ V  AR GS    +V G +K L + DFG PLHC++I G+ H 
Sbjct: 185 LLELENRKKEGIINEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIPGKLHF 244

Query: 362 VEEEMLEF 385
           +EE+ L++
Sbjct: 245 MEEDALKY 252

[163][TOP]
>UniRef100_C9RHT0 Diphthine synthase n=1 Tax=Methanocaldococcus vulcanius M7
           RepID=C9RHT0_9EURY
          Length = 257

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 49/126 (38%), Positives = 75/126 (59%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E + P++ Y  IK+N   GLHTLCLLDI++++              +  R+M+ N A+E 
Sbjct: 139 ENYFPETPYNVIKENLERGLHTLCLLDIKIED--------------DKKRFMTANEALEI 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL++E++ G  +  EDT  V  AR GS +  +V G +  L + DFG PLHC+++ G+ H 
Sbjct: 185 LLKLEERKGFGIISEDTWVVVVARAGSLNPKLVYGQIGNLINYDFGKPLHCVIVPGKLHF 244

Query: 362 VEEEML 379
           +EEE L
Sbjct: 245 MEEEAL 250

[164][TOP]
>UniRef100_Q5KEZ6 Diphthine synthase n=1 Tax=Filobasidiella neoformans
           RepID=Q5KEZ6_CRYNE
          Length = 337

 Score = 91.3 bits (225), Expect = 3e-17
 Identities = 58/171 (33%), Positives = 88/171 (51%), Gaps = 47/171 (27%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDS+Y ++++N  LG+HTL LLDI+V+E + E++ RG +  YEPPR+M+   A  Q
Sbjct: 138 ETWRPDSWYPRLEENLRLGVHTLVLLDIKVREQSEENMARG-RLIYEPPRFMNPAQAFNQ 196

Query: 182 LLEVEQ---------------------------KHGDSVYGED----------------T 232
           +L  E                             H DS   E+                T
Sbjct: 197 MLLTESIRHPAPRHPSQSQSTDQTQKPSQLPSSSHSDSEEEEEEAERVDPYPSLMPPSQT 256

Query: 233 QCVGFARLGSEDQTIVAGTMKQLESVD---FGAPLHCLVIVGE-THPVEEE 373
             +  +R+G+  Q +++GT+ +L ++D   FG PLH +VIVG+  HP+E E
Sbjct: 257 LAISLSRVGTPSQRLISGTLSELAALDEEEFGGPLHSVVIVGKRLHPLELE 307

[165][TOP]
>UniRef100_Q55R74 Diphthine synthase n=1 Tax=Filobasidiella neoformans
           RepID=Q55R74_CRYNE
          Length = 338

 Score = 90.9 bits (224), Expect = 4e-17
 Identities = 58/172 (33%), Positives = 88/172 (51%), Gaps = 48/172 (27%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETWRPDS+Y ++++N  LG+HTL LLDI+V+E + E++ RG +  YEPPR+M+   A  Q
Sbjct: 138 ETWRPDSWYPRLEENLRLGVHTLVLLDIKVREQSEENMARG-RLIYEPPRFMNPAQAFNQ 196

Query: 182 LLEVEQ---------------------------KHGDSVYGED----------------- 229
           +L  E                             H DS   E+                 
Sbjct: 197 MLLTESIRHPAPRHPSQSQSTDQTQKPSQLPSSSHSDSEEEEEEEAERVDPYPSLMPPSQ 256

Query: 230 TQCVGFARLGSEDQTIVAGTMKQLESVD---FGAPLHCLVIVGE-THPVEEE 373
           T  +  +R+G+  Q +++GT+ +L ++D   FG PLH +VIVG+  HP+E E
Sbjct: 257 TLAISLSRVGTPSQRLISGTLSELAALDEEEFGGPLHSVVIVGKRLHPLELE 308

[166][TOP]
>UniRef100_Q8SQT9 Diphthine synthase n=1 Tax=Encephalitozoon cuniculi
           RepID=Q8SQT9_ENCCU
          Length = 262

 Score = 89.4 bits (220), Expect = 1e-16
 Identities = 49/126 (38%), Positives = 65/126 (51%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+P SFY+ I +N    LHTLCLLDIR  E                 R+MSVN A++Q
Sbjct: 148 ERWKPTSFYDNIVRNHQSNLHTLCLLDIRTDED----------------RFMSVNEAVDQ 191

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           +LE     G  +  EDT+     R GS  + IV G +  L+   FG PLH L++  E   
Sbjct: 192 ILEAAAITGSPLINEDTRIFAVCRFGSPSEEIVYGKIGDLKLRSFGDPLHSLIVPAELDR 251

Query: 362 VEEEML 379
           VE E++
Sbjct: 252 VEAELV 257

[167][TOP]
>UniRef100_A6UU49 Probable diphthine synthase n=1 Tax=Methanococcus aeolicus Nankai-3
           RepID=DPHB_META3
          Length = 257

 Score = 89.4 bits (220), Expect = 1e-16
 Identities = 46/124 (37%), Positives = 70/124 (56%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y+ IK+N  +G HTLCLLDI                Q    R+M+ N  +E LL++
Sbjct: 143 PETPYDVIKENSKMGYHTLCLLDI----------------QAHNTRFMTANEGLEVLLKI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E+K  +++  +DT+ V  AR GS    +V G +  L   DFGAPLHC++  G  H +EE+
Sbjct: 187 EEKRNENILNKDTKVVVVARAGSLKPKMVYGKIGDLLEYDFGAPLHCIIFTGNLHFMEED 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[168][TOP]
>UniRef100_UPI0000D99A60 PREDICTED: DPH5 homolog (S. cerevisiae) isoform 1 n=1 Tax=Macaca
           mulatta RepID=UPI0000D99A60
          Length = 237

 Score = 89.0 bits (219), Expect = 2e-16
 Identities = 49/130 (37%), Positives = 66/130 (50%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLL I                                
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLAIT------------------------------- 166

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETH 358
                         E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  G  H
Sbjct: 167 --------------EETLCVGLARVGADDQKIAAGTLQQMCTVDLGEPLHSLIITGGSIH 212

Query: 359 PVEEEMLEFY 388
           P+E EML  +
Sbjct: 213 PIEMEMLNLF 222

[169][TOP]
>UniRef100_UPI0000E1EAA7 PREDICTED: similar to DPH5 protein isoform 1 n=1 Tax=Pan
           troglodytes RepID=UPI0000E1EAA7
          Length = 237

 Score = 88.2 bits (217), Expect = 3e-16
 Identities = 48/130 (36%), Positives = 66/130 (50%), Gaps = 1/130 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           +TWRP+SF++K+KKNR  G+HTLCLL +                                
Sbjct: 138 DTWRPESFFDKVKKNRQNGMHTLCLLAVT------------------------------- 166

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIV-GETH 358
                         E+T CVG AR+G++DQ I AGT++Q+ +VD G PLH L+I  G  H
Sbjct: 167 --------------EETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIH 212

Query: 359 PVEEEMLEFY 388
           P+E EML  +
Sbjct: 213 PMEMEMLSLF 222

[170][TOP]
>UniRef100_C4Q413 Diphthine synthase n=1 Tax=Schistosoma mansoni RepID=C4Q413_SCHMA
          Length = 329

 Score = 88.2 bits (217), Expect = 3e-16
 Identities = 51/142 (35%), Positives = 78/142 (54%), Gaps = 16/142 (11%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E   P+SFY+KI  N   G HTLCLLDI+VKE + E++ R  +K YEP R+MS   A+ Q
Sbjct: 137 EFGHPESFYDKIIMNMKSGFHTLCLLDIKVKERSLENILR-DRKVYEPSRFMSCCEAVHQ 195

Query: 182 LLEV-------EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQL---------ESVD 313
           +++V       +Q   ++V  +    +  +RLG ++Q IV  T+  +           ++
Sbjct: 196 IVDVSNRKAEDQQSRENAVITKSCIVICLSRLGCDNQKIVVSTISDINEAYLNPEKNGLN 255

Query: 314 FGAPLHCLVIVGETHPVEEEML 379
           FG P HC++I G  H +E   L
Sbjct: 256 FGDPPHCMIIPGIIHELESIFL 277

[171][TOP]
>UniRef100_C4VB00 Diphthine synthase n=1 Tax=Nosema ceranae BRL01 RepID=C4VB00_NOSCE
          Length = 250

 Score = 88.2 bits (217), Expect = 3e-16
 Identities = 51/127 (40%), Positives = 69/127 (54%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E WRP SF+  I  N   GLHTLCLLDI+V E                 RYMSVN A+ Q
Sbjct: 137 EDWRPLSFFNNILTNIKCGLHTLCLLDIKVDEN----------------RYMSVNEALNQ 180

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           +L ++    + V  E  +     R GS DQ I  GT+++L  ++FG PLH LVI  +   
Sbjct: 181 ILSIK----NDVVNEKYKVFAVCRFGSPDQFIKYGTIEELIKINFGKPLHSLVIPAQMDT 236

Query: 362 VEEEMLE 382
           +E+E++E
Sbjct: 237 IEKELVE 243

[172][TOP]
>UniRef100_A8TF34 Diphthine synthase n=1 Tax=Methanococcus voltae A3
           RepID=A8TF34_METVO
          Length = 255

 Score = 87.8 bits (216), Expect = 3e-16
 Identities = 49/123 (39%), Positives = 68/123 (55%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y  IK N SLG HTLCLLDI   E  F                M+ N  ++ LL++
Sbjct: 143 PETPYNVIKDNLSLGYHTLCLLDIHAHENKF----------------MTANEGLQVLLDI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E++  + +  EDT+ +  AR GS    +V G +K L   DFGAPLH ++I+G  H +EEE
Sbjct: 187 EKRREEKLLSEDTKVLVVARAGSLKPKLVYGKIKDLIKQDFGAPLHSIIILGNLHFMEEE 246

Query: 374 MLE 382
            LE
Sbjct: 247 ALE 249

[173][TOP]
>UniRef100_A4FYP1 Probable diphthine synthase n=1 Tax=Methanococcus maripaludis C5
           RepID=DPHB_METM5
          Length = 255

 Score = 87.4 bits (215), Expect = 4e-16
 Identities = 46/124 (37%), Positives = 68/124 (54%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y+ IK N  LG HTLCLLDI                Q +  R+M+ N  +  LLE+
Sbjct: 143 PETPYDVIKDNLKLGYHTLCLLDI----------------QADKERFMTANEGLSALLEI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E+K  ++V   +T     AR GS    +  G +K L + DFG PLHC++I G+ H +EE+
Sbjct: 187 EEKRNENVISGETHAAVVARAGSTKPGLYYGKIKDLINYDFGTPLHCVIIPGKLHFMEED 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[174][TOP]
>UniRef100_Q6LZN6 Probable diphthine synthase n=1 Tax=Methanococcus maripaludis
           RepID=DPHB_METMP
          Length = 255

 Score = 86.3 bits (212), Expect = 1e-15
 Identities = 45/124 (36%), Positives = 72/124 (58%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y+ IK N  LG HTLCLLDI                Q +  R+M+ N  ++ LL++
Sbjct: 143 PETPYDVIKDNLKLGYHTLCLLDI----------------QADKERFMTANEGLDALLKI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E+K  ++V  E+T+    AR GS +  +  G +K L + DF +PLHC++I G+ H +EE+
Sbjct: 187 EEKRKENVISEETEVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKLHFMEED 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[175][TOP]
>UniRef100_A6VJP1 Probable diphthine synthase n=1 Tax=Methanococcus maripaludis C7
           RepID=DPHB_METM7
          Length = 255

 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 45/124 (36%), Positives = 69/124 (55%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y+ IK N  LG HTLCLLDI                Q +  R+M+ N  ++ LL++
Sbjct: 143 PETPYDVIKDNLKLGYHTLCLLDI----------------QADKERFMTANEGLDALLKI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E+K  ++V   +T     AR GS    +  G +K L + DFG PLHC++I G+ H +EE+
Sbjct: 187 EEKRNENVISGETYAAVVARAGSIKPGLYYGKIKDLINYDFGTPLHCVIIPGKLHFMEED 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[176][TOP]
>UniRef100_C5U7L9 Diphthine synthase n=1 Tax=Methanocaldococcus infernus ME
           RepID=C5U7L9_9EURY
          Length = 256

 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 47/124 (37%), Positives = 70/124 (56%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y  IK+N   G HTLCLLDI  +E                 R+M+ N A++ LLE+
Sbjct: 143 PETPYNVIKENLERGCHTLCLLDIHAEEN----------------RFMTANEALKILLEL 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E++  + V  ED + +  AR GS    +V G +K L + DFG PLH ++I G+ H +EEE
Sbjct: 187 EKRKKEGVISEDMKVIVLARAGSLKPKLVYGKIKDLLNYDFGKPLHSIIIPGKLHFMEEE 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[177][TOP]
>UniRef100_A6US81 Probable diphthine synthase n=1 Tax=Methanococcus vannielii SB
           RepID=DPHB_METVS
          Length = 255

 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 45/124 (36%), Positives = 70/124 (56%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y+ IK N SLG HTLCLLDI                Q +  ++M+ N  +  LLE+
Sbjct: 143 PETPYDVIKDNLSLGYHTLCLLDI----------------QTDKQKFMTANEGLSVLLEI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E+K  + +  E+T+ +  AR GS    +  G +K L   DFG PLHC++I+G+ H +E +
Sbjct: 187 EEKRKEKIIDENTKVLVVARAGSIKPGLFYGKIKDLIKHDFGTPLHCVIILGKLHFMETD 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[178][TOP]
>UniRef100_O58456 Probable diphthine synthase n=1 Tax=Pyrococcus horikoshii
           RepID=DPHB_PYRHO
          Length = 265

 Score = 84.3 bits (207), Expect = 4e-15
 Identities = 51/124 (41%), Positives = 65/124 (52%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P S+Y+ IK+N   GLHTL  LDI+                 E   YM+ N A+E LL
Sbjct: 143 WFPTSYYDVIKENAERGLHTLLFLDIKA----------------EKRMYMTANEAMELLL 186

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           +VE      V+ +DT  V  AR GS + TI AG +K L   DFG P H L++ G+ H VE
Sbjct: 187 KVEDMKKGGVFTDDTLVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPGKLHIVE 246

Query: 368 EEML 379
            E L
Sbjct: 247 AEYL 250

[179][TOP]
>UniRef100_A8Q3D9 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8Q3D9_MALGO
          Length = 303

 Score = 84.0 bits (206), Expect = 5e-15
 Identities = 46/107 (42%), Positives = 66/107 (61%), Gaps = 7/107 (6%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+PDS+  +I +N  LGLHTLCL DI+V+E + E + R G  +Y+PPRYM +   I Q
Sbjct: 104 EDWQPDSWLFRIGENSQLGLHTLCLSDIKVREQSIEDMSR-GIARYQPPRYMLIPQLIAQ 162

Query: 182 LLEVEQKHG-DSVYGEDTQCVGFARLGSED------QTIVAGTMKQL 301
           L+   Q H  D ++ E T  +   R+G+ED      + IVAGT+ +L
Sbjct: 163 LVAAAQHHQVDYLHPERTLAIALCRMGAEDSATRRGELIVAGTLAEL 209

[180][TOP]
>UniRef100_B7R444 Diphthine synthase n=1 Tax=Thermococcus sp. AM4 RepID=B7R444_9EURY
          Length = 264

 Score = 84.0 bits (206), Expect = 5e-15
 Identities = 50/126 (39%), Positives = 66/126 (52%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P S Y+ IK+NR  GLHTL  LDI+                 E  RYM+ N A+E 
Sbjct: 141 KNWFPTSHYDVIKENRERGLHTLLFLDIKA----------------EQNRYMTANEAMEI 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL VE++ G+ V+  +T  V  AR GS + TI AG +  +   DFG   H L++ G  H 
Sbjct: 185 LLRVEERKGEGVFTPETLVVVLARAGSLNPTIRAGYVGDMIHEDFGRQPHVLIVPGRLHI 244

Query: 362 VEEEML 379
           VE E L
Sbjct: 245 VEAEYL 250

[181][TOP]
>UniRef100_C5A3K4 Probable diphthine synthase n=1 Tax=Thermococcus gammatolerans EJ3
           RepID=DPHB_THEGJ
          Length = 264

 Score = 83.6 bits (205), Expect = 6e-15
 Identities = 49/124 (39%), Positives = 65/124 (52%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P S+Y+ IK+NR  GLHTL  LDI+                 E  RYM+ N A+E LL
Sbjct: 143 WFPTSYYDVIKENRERGLHTLLFLDIKA----------------EQNRYMTANEAMEILL 186

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           +VE    + ++  +T  V  AR GS + TI AG +K +   DFG   H L++ G  H VE
Sbjct: 187 QVEDMKKEGIFTPETLVVVLARAGSLNPTIRAGYVKDMIHEDFGRQPHVLIVPGRLHVVE 246

Query: 368 EEML 379
            E L
Sbjct: 247 AEYL 250

[182][TOP]
>UniRef100_Q4P657 Diphthine synthase n=1 Tax=Ustilago maydis RepID=Q4P657_USTMA
          Length = 331

 Score = 83.2 bits (204), Expect = 8e-15
 Identities = 56/171 (32%), Positives = 81/171 (47%), Gaps = 42/171 (24%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E W+PDS+ E+I +N  +GLHTL L DI+V+E + + + R G  +Y+ PRYM +   I Q
Sbjct: 143 EDWKPDSWLERIGENLHIGLHTLALSDIKVREQSAQDMSR-GILRYQDPRYMLIPQLISQ 201

Query: 182 LLEVEQKHG-DSVYGEDTQCVGFARLGSEDQTIVAGTMKQL-----------------ES 307
           L+     H  D +    T  +   R+GSED+ IV+GT+ +L                 + 
Sbjct: 202 LISAANSHKVDYLDPNRTLAIALCRMGSEDERIVSGTLSELLDMANPSPEQAQAEGAEDD 261

Query: 308 VD-----------------------FGAPLHCLVIVGE-THPVEEEMLEFY 388
            D                       FG PLH LVIVG+  HP+E +    Y
Sbjct: 262 ADEMASEAELDKRRAARAEARAKNVFGEPLHSLVIVGKRLHPLERDYAANY 312

[183][TOP]
>UniRef100_Q8U377 Probable diphthine synthase n=1 Tax=Pyrococcus furiosus
           RepID=DPHB_PYRFU
          Length = 269

 Score = 83.2 bits (204), Expect = 8e-15
 Identities = 47/124 (37%), Positives = 67/124 (54%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P S+Y+ +K+N   GLHTL  LDI+                 E  +YM+ N A+E LL
Sbjct: 143 WFPTSYYDVVKENLERGLHTLLFLDIKA----------------EKGKYMTANEAMELLL 186

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           +VE+  G++V+  +T  V   R GS + TI AG +K +   DFG   H L++ G+ H VE
Sbjct: 187 KVEEMRGENVFTPNTLVVVLGRAGSLNPTIRAGYVKDMIKEDFGKQPHVLIVPGKLHVVE 246

Query: 368 EEML 379
            E L
Sbjct: 247 AEYL 250

[184][TOP]
>UniRef100_A9A6D8 Probable diphthine synthase n=1 Tax=Methanococcus maripaludis C6
           RepID=DPHB_METM6
          Length = 255

 Score = 83.2 bits (204), Expect = 8e-15
 Identities = 44/124 (35%), Positives = 68/124 (54%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P++ Y+ IK N  LG HTLCLLDI                Q +  R+M+ N  ++ LL++
Sbjct: 143 PETPYDVIKDNLKLGYHTLCLLDI----------------QADKERFMTANEGLDTLLKI 186

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E+K  + V   +T     AR GS    +  G +K L + DF +PLHC++I G+ H +EE+
Sbjct: 187 EEKRNEKVISGETYAAVVARAGSTKPGLYYGKIKDLINYDFKSPLHCVIIPGKLHFMEED 246

Query: 374 MLEF 385
            L++
Sbjct: 247 ALKY 250

[185][TOP]
>UniRef100_UPI0001966737 hypothetical protein METSMIF1_01009 n=1 Tax=Methanobrevibacter
           smithii DSM 2374 RepID=UPI0001966737
          Length = 270

 Score = 82.8 bits (203), Expect = 1e-14
 Identities = 50/123 (40%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S Y  I++N ++ LHTL LLDI                Q    RYM+VN  +E L+ +
Sbjct: 150 PKSPYTAIEENLAMELHTLVLLDI----------------QAHKDRYMTVNQGLEYLMNI 193

Query: 194 EQKHG-DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEE 370
           +     D    EDT  VG AR+GS+D  + AG + QL   DFG PLHC+VI  + H VE 
Sbjct: 194 KNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLHCIVIPSKLHIVEA 253

Query: 371 EML 379
           E L
Sbjct: 254 EYL 256

[186][TOP]
>UniRef100_C6A0P7 Diphthine synthase n=1 Tax=Thermococcus sibiricus MM 739
           RepID=C6A0P7_THESM
          Length = 268

 Score = 82.8 bits (203), Expect = 1e-14
 Identities = 47/126 (37%), Positives = 67/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P S YE IK+N+  GLHTL  LDI+                 E  +YM+ N A+  
Sbjct: 145 KNWFPTSHYEVIKENKERGLHTLLFLDIKA----------------EQKKYMTANEAMNI 188

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL+VE+   + ++ EDT  V  AR GS   T+ AG ++++   DFG   H L++ G+ H 
Sbjct: 189 LLQVEEMKKEEIFTEDTLVVILARAGSLTPTLKAGYVREMIKEDFGKQPHILIVPGKLHI 248

Query: 362 VEEEML 379
           VE E L
Sbjct: 249 VEAEYL 254

[187][TOP]
>UniRef100_A5ULC8 Diphthine synthase n=1 Tax=Methanobrevibacter smithii ATCC 35061
           RepID=A5ULC8_METS3
          Length = 270

 Score = 82.8 bits (203), Expect = 1e-14
 Identities = 50/123 (40%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S Y  I++N ++ LHTL LLDI                Q    RYM+VN  +E L+ +
Sbjct: 150 PKSPYTAIEENLAMELHTLVLLDI----------------QAHKDRYMTVNQGLEYLMNI 193

Query: 194 EQKHG-DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEE 370
           +     D    EDT  VG AR+GS+D  + AG + QL   DFG PLHC+VI  + H VE 
Sbjct: 194 KNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLHCIVIPSKLHIVEA 253

Query: 371 EML 379
           E L
Sbjct: 254 EYL 256

[188][TOP]
>UniRef100_B9AED4 Diphthine synthase n=1 Tax=Methanobrevibacter smithii DSM 2375
           RepID=B9AED4_METSM
          Length = 270

 Score = 82.8 bits (203), Expect = 1e-14
 Identities = 50/123 (40%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S Y  I++N ++ LHTL LLDI                Q    RYM+VN  +E L+ +
Sbjct: 150 PKSPYTAIEENLAMELHTLVLLDI----------------QAHKDRYMTVNQGLEYLMNI 193

Query: 194 EQKHG-DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEE 370
           +     D    EDT  VG AR+GS+D  + AG + QL   DFG PLHC+VI  + H VE 
Sbjct: 194 KNTLDYDGAVTEDTLAVGIARVGSKDVVVKAGKISQLIDYDFGGPLHCIVIPSKLHIVEA 253

Query: 371 EML 379
           E L
Sbjct: 254 EYL 256

[189][TOP]
>UniRef100_Q2NFJ8 Probable diphthine synthase n=1 Tax=Methanosphaera stadtmanae DSM
           3091 RepID=DPHB_METST
          Length = 263

 Score = 82.8 bits (203), Expect = 1e-14
 Identities = 44/126 (34%), Positives = 67/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E + P S Y+ IK N  +GLHTL LLDI                Q    RYM+VN A++ 
Sbjct: 139 ENFFPHSPYDAIKLNSQMGLHTLVLLDI----------------QAHKDRYMTVNQALDY 182

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           L +VE +  + V+ +D   +G A+ GS+   +  G +  +++ DFG PLHC+++    H 
Sbjct: 183 LSKVESERKEHVFDDDRIVIGIAQAGSKHPIVKGGRVSDVKNFDFGKPLHCIIVPANLHF 242

Query: 362 VEEEML 379
           +E E L
Sbjct: 243 IEAEAL 248

[190][TOP]
>UniRef100_Q59NX3 Potential diphthamide methyltransferase n=1 Tax=Candida albicans
           RepID=Q59NX3_CANAL
          Length = 124

 Score = 82.4 bits (202), Expect = 1e-14
 Identities = 41/86 (47%), Positives = 55/86 (63%), Gaps = 1/86 (1%)
 Frame = +2

Query: 125 GKKQYEPPRYMSVNTAIEQLLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLE 304
           G+  YEPPRYM + TA +QLLE+E    +  Y  +T CV  +RLGS  QT  AGT+++L 
Sbjct: 4   GRLIYEPPRYMDIATAAQQLLEIESIRQEQAYTPNTPCVAISRLGSPTQTFKAGTLQELS 63

Query: 305 SVDFGAPLHCLVIVG-ETHPVEEEML 379
             D G PLH LV++G + H +E E L
Sbjct: 64  EYDSGEPLHSLVMLGRQVHELELEYL 89

[191][TOP]
>UniRef100_B6YXP9 Probable diphthine synthase n=1 Tax=Thermococcus onnurineus NA1
           RepID=DPHB_THEON
          Length = 264

 Score = 82.4 bits (202), Expect = 1e-14
 Identities = 46/126 (36%), Positives = 68/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P S Y+ I++N+  GLHT+  LDI+                 +  RYM+ N A+E 
Sbjct: 141 KNWFPTSHYDVIRENKERGLHTMLFLDIKA----------------DQNRYMTANEAMEI 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL+VE+  G+ V+  DT  V  AR GS + T+ AG ++ + + DFG   H +V+ G  H 
Sbjct: 185 LLQVEEMKGEGVFTPDTLVVVLARAGSLNPTLKAGYVRDMLNEDFGRQPHVMVVPGRLHI 244

Query: 362 VEEEML 379
           VE E L
Sbjct: 245 VEAEYL 250

[192][TOP]
>UniRef100_Q5JFE7 Probable diphthine synthase n=1 Tax=Thermococcus kodakarensis
           RepID=DPHB_PYRKO
          Length = 264

 Score = 82.4 bits (202), Expect = 1e-14
 Identities = 47/126 (37%), Positives = 68/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P S Y+ I+ N+  GLHTL  LDI+                 +  RYM+ N A+E 
Sbjct: 141 KNWFPTSHYDVIRDNKERGLHTLLFLDIKA----------------DQNRYMTANEAMEI 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL+VE+  G+ V+  +T  V  AR GS + T+ AG +++L + DFG   H L++ G  H 
Sbjct: 185 LLKVEEMKGEGVFTPETLVVVLARAGSLEPTLRAGYVRELINEDFGRQPHVLIVPGRLHI 244

Query: 362 VEEEML 379
           VE E L
Sbjct: 245 VEAEYL 250

[193][TOP]
>UniRef100_Q2H1G4 Diphthine synthase n=1 Tax=Chaetomium globosum RepID=Q2H1G4_CHAGB
          Length = 250

 Score = 82.0 bits (201), Expect = 2e-14
 Identities = 41/94 (43%), Positives = 63/94 (67%), Gaps = 3/94 (3%)
 Frame = +2

Query: 107 ESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAG 286
           E++ RG +K YEPPRYMSV T  +Q+LE+E++ G   YG ++  +G AR+G + +  VAG
Sbjct: 136 ENMARG-RKIYEPPRYMSVGTCAQQMLEIEEEKGLGAYGPESLAIGAARVGGKTEKFVAG 194

Query: 287 TMKQLESVD--FGAPLHCLVIVG-ETHPVEEEML 379
           T+K+L   D   G PLH +V++G  TH +E + +
Sbjct: 195 TLKELCDADEELGPPLHSMVLLGRRTHELEHDFV 228

[194][TOP]
>UniRef100_Q467Z4 Probable diphthine synthase n=1 Tax=Methanosarcina barkeri str.
           Fusaro RepID=DPHB_METBF
          Length = 266

 Score = 80.1 bits (196), Expect = 7e-14
 Identities = 50/118 (42%), Positives = 64/118 (54%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y+ IK+N  LGLHTL  LDI  ++                  YM+VNTA+E LLEVE+K 
Sbjct: 152 YDTIKQNLELGLHTLVFLDIDKEKG-----------------YMTVNTALELLLEVEEKR 194

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEML 379
           G+ +       VG AR GSE   I A   + L+  +FG PLH LVI G+ H +E E L
Sbjct: 195 GEGIM-RGAAAVGIARAGSEKPVIRADYAENLKDFNFGKPLHILVIPGKLHFLEAEAL 251

[195][TOP]
>UniRef100_Q8PUH9 Probable diphthine synthase n=1 Tax=Methanosarcina mazei
           RepID=DPHB_METMA
          Length = 266

 Score = 79.7 bits (195), Expect = 9e-14
 Identities = 49/118 (41%), Positives = 63/118 (53%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y+ IK+N S GLHTL  LDI                  +   +MSVN A++ LLEVE K 
Sbjct: 152 YDTIKQNSSFGLHTLVFLDID-----------------KDKGFMSVNIALKLLLEVESKR 194

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEML 379
           G+ V  +    VG AR GSE   + AG  + L+  DFG PLH LV+ G+ H +E E L
Sbjct: 195 GEGVM-DRAVAVGIARAGSEKPVVKAGYAEDLKGFDFGKPLHILVVPGKLHFLEAEAL 251

[196][TOP]
>UniRef100_B5ISH7 Diphthine synthase n=1 Tax=Thermococcus barophilus MP
           RepID=B5ISH7_9EURY
          Length = 266

 Score = 79.0 bits (193), Expect = 2e-13
 Identities = 46/126 (36%), Positives = 67/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P S YE IK+N+  GLHTL  LDI+                 +  RYM+ N A++ 
Sbjct: 141 KNWFPTSHYEVIKENKERGLHTLLFLDIKA----------------DQGRYMTANEAMDI 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL+VE+    +V+  +T  V  AR GS + T+ AG ++ +   DFG   H +V+ G  H 
Sbjct: 185 LLQVEEMKRQNVFTPETFVVVLARAGSLNPTLKAGYVEDMIKEDFGKQPHIMVVPGRLHI 244

Query: 362 VEEEML 379
           VE+E L
Sbjct: 245 VEKEYL 250

[197][TOP]
>UniRef100_Q9UZ31 Probable diphthine synthase n=1 Tax=Pyrococcus abyssi
           RepID=DPHB_PYRAB
          Length = 262

 Score = 79.0 bits (193), Expect = 2e-13
 Identities = 45/126 (35%), Positives = 66/126 (52%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P S+Y+ IK+N   GLHTL  LDI+                 E  +YM+ N  ++ 
Sbjct: 141 KNWFPTSYYDVIKENLERGLHTLLFLDIKA----------------EKGKYMTANEGMKL 184

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL+VE    + V+ ++T  V  AR GS +  I AG ++ +   DFG+P H L++ G  H 
Sbjct: 185 LLKVEDMKKEGVFTQETLVVVLARAGSLNPVIRAGYVRDMIREDFGSPPHVLIVPGRLHI 244

Query: 362 VEEEML 379
           VE E L
Sbjct: 245 VEAEYL 250

[198][TOP]
>UniRef100_B5IBN6 Diphthine synthase n=1 Tax=Aciduliprofundum boonei T469
           RepID=B5IBN6_9EURY
          Length = 258

 Score = 78.2 bits (191), Expect = 3e-13
 Identities = 47/126 (37%), Positives = 68/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E + P S Y+ IK N++LGLHTL LLDI                    PR M+ N A++ 
Sbjct: 139 ENYFPTSAYDFIKINQNLGLHTLILLDIN-------------------PRPMTANEAMKI 179

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+E+K  + ++ E+T     AR G+ +    AG +  + + DFG+PLH LV+ G+ H 
Sbjct: 180 LLEMEEKKREKIFSENTLIAVVARAGAPNSLARAGYLGDMINEDFGSPLHTLVLPGKLHF 239

Query: 362 VEEEML 379
            E E L
Sbjct: 240 AEAEAL 245

[199][TOP]
>UniRef100_A6SQS2 Diphthamide methyltransferase n=1 Tax=Botryotinia fuckeliana B05.10
           RepID=A6SQS2_BOTFB
          Length = 153

 Score = 77.4 bits (189), Expect = 5e-13
 Identities = 44/99 (44%), Positives = 65/99 (65%), Gaps = 4/99 (4%)
 Frame = +2

Query: 89  VKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKHGDS-VYGEDTQCVGFARLGSE 265
           VKE T E++ RG +K YEPPRYM++        E++ ++G+  VY E++ CVG AR+G +
Sbjct: 39  VKEQTMENMARG-RKIYEPPRYMTIE-------EMKTENGEGGVYNEESLCVGAARVGCK 90

Query: 266 DQTIVAGTMKQLESVD--FGAPLHCLVIVG-ETHPVEEE 373
           D+  V+GT+KQL   D   G PLH LV++G  TH +E +
Sbjct: 91  DEKFVSGTLKQLCDADEQLGGPLHSLVLLGRRTHELEHD 129

[200][TOP]
>UniRef100_B8GIF8 Probable diphthine synthase n=1 Tax=Methanosphaerula palustris
           E1-9c RepID=DPHB_METPE
          Length = 251

 Score = 76.6 bits (187), Expect = 8e-13
 Identities = 46/129 (35%), Positives = 64/129 (49%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + W P + YE +++N +  LHTL  LDI                  +  RYM V  AI+ 
Sbjct: 140 KNWFPLTPYEVVRQNLAADLHTLVYLDI------------------QQDRYMRVGEAIDL 181

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           L E+  + G S+    T  +G AR GS    + AGT   L  +DFG PLH L++    HP
Sbjct: 182 LEEMAVRVGGSI----TTYIGVARAGSVSPVVRAGTADHLRGIDFGGPLHVLIVPATLHP 237

Query: 362 VEEEMLEFY 388
           VE+E LE +
Sbjct: 238 VEQEYLEVF 246

[201][TOP]
>UniRef100_B5I9W5 Diphthine synthase n=1 Tax=Aciduliprofundum boonei T469
           RepID=B5I9W5_9EURY
          Length = 258

 Score = 76.3 bits (186), Expect = 1e-12
 Identities = 46/126 (36%), Positives = 68/126 (53%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E + P S Y+ IK N++LGLHTL LLDI                    PR M+ N A++ 
Sbjct: 139 ENYFPTSAYDFIKINQNLGLHTLILLDIN-------------------PRPMTANEAMKI 179

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LLE+E+K  + ++ ++T     AR G+ +    AG +  + + DFG+PLH LV+ G+ H 
Sbjct: 180 LLEMEEKKREKIFSKNTLIAVVARAGAPNSLARAGYLGDMINGDFGSPLHTLVLPGKLHF 239

Query: 362 VEEEML 379
            E E L
Sbjct: 240 AEAEAL 245

[202][TOP]
>UniRef100_Q8TR14 Probable diphthine synthase n=1 Tax=Methanosarcina acetivorans
           RepID=DPHB_METAC
          Length = 266

 Score = 75.9 bits (185), Expect = 1e-12
 Identities = 46/118 (38%), Positives = 62/118 (52%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y+ IK+N  LGLHT+  LDI                  +   YM+ N A+E LLEVE++ 
Sbjct: 152 YDTIKQNSELGLHTMIFLDID-----------------KDKGYMTANHALELLLEVEKRR 194

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEML 379
           G+ +  E    VG AR GSE   + A   + L+  DFG PLH LV+ G+ H +E E L
Sbjct: 195 GEGIM-ERAVAVGIARAGSEKPVVKADYAESLKDFDFGNPLHILVVPGKLHFLEAEAL 251

[203][TOP]
>UniRef100_Q4UHG5 Diphthine synthase n=1 Tax=Theileria annulata RepID=Q4UHG5_THEAN
          Length = 309

 Score = 75.5 bits (184), Expect = 2e-12
 Identities = 53/152 (34%), Positives = 73/152 (48%), Gaps = 21/152 (13%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYM-------- 157
           E W+P SFY+KI +N +  LHTLCLLDI+V+E + E++ +  K  +E P Y+        
Sbjct: 159 ENWKPFSFYDKIMQNYNNNLHTLCLLDIKVRERSVENIMK-NKLIFEEPSYLLPVIYNFE 217

Query: 158 -SVNTAIEQLLEVEQKHGDSVYGE------------DTQCVGFARLGSEDQTIVAGTMKQ 298
             +      +      H  + Y              D   +G ARL SEDQ I +G ++ 
Sbjct: 218 FGIFPYYSNINMNTVTHYHNYYYNFTIILRFKIGKIDFMVIGIARLSSEDQIIKSGKLED 277

Query: 299 LESVDFGAPLHCLVIVGETHPVEEEMLEFYKY 394
           L + DFG PLH L IV   H    E L F  Y
Sbjct: 278 LLNFDFGPPLHSL-IVCSPHLHHYEQLFFNHY 308

[204][TOP]
>UniRef100_C5KZ48 Diphthine synthase, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5KZ48_9ALVE
          Length = 101

 Score = 73.9 bits (180), Expect = 5e-12
 Identities = 41/98 (41%), Positives = 62/98 (63%), Gaps = 9/98 (9%)
 Frame = +2

Query: 125 GKKQYEPPRYMSVNTAIEQLLEVEQKHGD-SVYGEDTQCVGFARLGSEDQTIVAGTMKQL 301
           G + YEPPR+MSV TA+EQL+E+++K G+  + G+D+  VG AR+G +DQ+IV G  + +
Sbjct: 3   GNEIYEPPRFMSVQTALEQLMEIDEKRGNPGIVGKDSLVVGVARVGCKDQSIVFGRAEDV 62

Query: 302 ----ESVDFGAPLHCLVIVGE----THPVEEEMLEFYK 391
                S   G PLH LVI  +       +EEE ++ Y+
Sbjct: 63  ASEKASEKLGGPLHSLVICAQGAEGLQEMEEEFVKQYQ 100

[205][TOP]
>UniRef100_Q0W085 Probable diphthine synthase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=DPHB_UNCMA
          Length = 257

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 43/119 (36%), Positives = 63/119 (52%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y+ I  N+  GLHTL  LDI  ++                  YM+VN  IE LL+VE++ 
Sbjct: 149 YDTILMNKKNGLHTLLFLDIDREKG-----------------YMTVNRGIELLLKVEERR 191

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEMLE 382
            +        CVG AR GS    + AG +++L++ DFG PLH +V+  + H +EEE L+
Sbjct: 192 KEGAVA-GALCVGIARAGSPSPCVRAGRIEELQAFDFGGPLHIMVMPADLHFLEEEALQ 249

[206][TOP]
>UniRef100_C5LRK1 Diphthine synthase, putative (Fragment) n=1 Tax=Perkinsus marinus
           ATCC 50983 RepID=C5LRK1_9ALVE
          Length = 91

 Score = 71.2 bits (173), Expect = 3e-11
 Identities = 37/78 (47%), Positives = 53/78 (67%), Gaps = 5/78 (6%)
 Frame = +2

Query: 125 GKKQYEPPRYMSVNTAIEQLLEVEQKHGD-SVYGEDTQCVGFARLGSEDQTIVAGTMKQL 301
           G + YEPPR+MSV TA+EQL+E+++K G+  + G+D+  VG AR+G +DQ+IV G  + +
Sbjct: 3   GNEIYEPPRFMSVQTALEQLMEIDEKRGNPGIVGKDSLVVGVARVGCKDQSIVFGRAEDV 62

Query: 302 ----ESVDFGAPLHCLVI 343
                S   G PLH LVI
Sbjct: 63  ASEKASEKLGGPLHSLVI 80

[207][TOP]
>UniRef100_A9CSS2 Diphthine synthase n=1 Tax=Enterocytozoon bieneusi H348
           RepID=A9CSS2_ENTBH
          Length = 252

 Score = 70.1 bits (170), Expect = 7e-11
 Identities = 39/128 (30%), Positives = 62/128 (48%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ETW+P SFY+ I KN    LHTLCLLDI+V E                 ++MS   A+ Q
Sbjct: 138 ETWKPISFYDSIYKNYINNLHTLCLLDIKVDE----------------NKFMSATEALRQ 181

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL  E++    +   +T+     R  ++ + +    + +L   DFG PLH ++   +   
Sbjct: 182 LLYAEEQTKYGLITPETKIFVVCRFATDTEKVYYNIIDKLLQEDFGEPLHSIIFPAKLSL 241

Query: 362 VEEEMLEF 385
           +E E + +
Sbjct: 242 IESEFINY 249

[208][TOP]
>UniRef100_A1RY11 Diphthine synthase n=1 Tax=Thermofilum pendens Hrk 5
           RepID=A1RY11_THEPD
          Length = 287

 Score = 70.1 bits (170), Expect = 7e-11
 Identities = 44/129 (34%), Positives = 65/129 (50%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P + Y  +K N S GLHT+ LLDIR  E                 RYM    A E LL +
Sbjct: 148 PYTPYSVLKDNVSRGLHTIFLLDIRADEG----------------RYMLFREASELLLRL 191

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
           E++  ++V  E+T  +G AR  +ED+ + AG + +  + D G   H L++ GE H  E  
Sbjct: 192 EERFQENVVDENTLVIGVARATAEDEKVFAGRISEAINADLGNAPHTLIVPGELHDSE-- 249

Query: 374 MLEFYKYKS 400
            ++F  YK+
Sbjct: 250 -IDFLHYKT 257

[209][TOP]
>UniRef100_A3CWF9 Probable diphthine synthase n=1 Tax=Methanoculleus marisnigri JR1
           RepID=DPHB_METMJ
          Length = 250

 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 46/127 (36%), Positives = 58/127 (45%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P +  E I  N +L LHTL  LDI                  +  RYM V  AI  L 
Sbjct: 142 WFPTAPIETIAANLALNLHTLVFLDI------------------QNDRYMRVPEAIAVLE 183

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           E+ +K G          VG AR GSE   + AG    L+ +DFG PLH L +  + HP+E
Sbjct: 184 EMAEKRGIE---PPALYVGIARAGSERPVVAAGAGANLKEMDFGPPLHILAVPADLHPME 240

Query: 368 EEMLEFY 388
            E LE +
Sbjct: 241 REYLETF 247

[210][TOP]
>UniRef100_A7IA21 Probable diphthine synthase n=1 Tax=Candidatus Methanoregula boonei
           6A8 RepID=DPHB_METB6
          Length = 250

 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 47/124 (37%), Positives = 60/124 (48%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P S  + I +NR+  LHTL  LDI                  +  RYM+VN  I  L 
Sbjct: 142 WAPSSPLDVILENRTNRLHTLVYLDI------------------QDDRYMTVNEGICLLE 183

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
            + QK   ++       VG AR GSE   + AGT + L S DFG PLH L++ GE H +E
Sbjct: 184 AMAQKKQVAI----PFYVGVARAGSETSLVRAGTAETLRSADFGPPLHILIVPGELHDME 239

Query: 368 EEML 379
            E L
Sbjct: 240 REYL 243

[211][TOP]
>UniRef100_Q7SYW0 Diphthine synthase n=1 Tax=Xenopus laevis RepID=Q7SYW0_XENLA
          Length = 241

 Score = 58.5 bits (140), Expect(2) = 2e-10
 Identities = 23/38 (60%), Positives = 33/38 (86%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESL 115
           + W+P+SFY+KI++NR  G+HTLCLLDI+VKE + E+L
Sbjct: 138 DMWKPESFYDKIRRNRLSGMHTLCLLDIKVKEQSIENL 175

 Score = 30.4 bits (67), Expect(2) = 2e-10
 Identities = 13/38 (34%), Positives = 19/38 (50%)
 Frame = +1

Query: 229 HTVCGLCPAWL*GPDDSCRDDEATRKR*FWSTVALSCD 342
           H +CG    W  GP++  RD  A +    W + +LS D
Sbjct: 182 HNLCGTGSCWCFGPENISRDPAAAKLGGLWGSSSLSGD 219

[212][TOP]
>UniRef100_Q5V2B7 Probable diphthine synthase n=1 Tax=Haloarcula marismortui
           RepID=DPHB_HALMA
          Length = 259

 Score = 67.8 bits (164), Expect = 4e-10
 Identities = 46/123 (37%), Positives = 58/123 (47%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           PDS    I+ NR   LHTL  LDI+V +P +E              YM+ + A   L E 
Sbjct: 147 PDSVVATIEDNRDRDLHTLVYLDIKVDDPHWEE---------SDDTYMTASQAATMLSEP 197

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                      DT  V  AR GS D  + A T+ +L +  FG PLH LVI G  HP+E +
Sbjct: 198 FP---------DTLGVVVARAGSPDPLVAADTLDELATQTFGDPLHLLVIPGSLHPLEAD 248

Query: 374 MLE 382
            LE
Sbjct: 249 TLE 251

[213][TOP]
>UniRef100_A0B879 Probable diphthine synthase n=1 Tax=Methanosaeta thermophila PT
           RepID=DPHB_METTP
          Length = 265

 Score = 67.4 bits (163), Expect = 5e-10
 Identities = 42/118 (35%), Positives = 57/118 (48%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y  +K N    LHTL  LDI                  +  R+M +N A   L+EV    
Sbjct: 151 YNAVKDNLRRDLHTLLYLDI------------------QDERFMCINEAAALLIEVANGS 192

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEML 379
           GD  +  +   VG AR GSED  + AGT+ +L++  FG PLH +VI G  H +E + L
Sbjct: 193 GDEDFASNL-AVGIARAGSEDMCVRAGTLLELKTYSFGPPLHVMVIPGRLHFMEAKAL 249

[214][TOP]
>UniRef100_A8BBU1 Diphthine synthase n=1 Tax=Giardia lamblia ATCC 50803
           RepID=A8BBU1_GIALA
          Length = 290

 Score = 66.6 bits (161), Expect = 8e-10
 Identities = 42/134 (31%), Positives = 67/134 (50%), Gaps = 6/134 (4%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           TWRP SF +   +N  L LHTL LL +  +E   +  C  G ++Y  P Y+  N A  Q+
Sbjct: 142 TWRPSSFMDYYLENARLNLHTLVLLQMSTRELDMDLYCNKGLERYSDPYYLLPNQAARQI 201

Query: 185 LEVEQKHGDSV--YGEDTQCVGFARLGSEDQTIVAGTMKQLESVD---FGAPLHCLVIVG 349
           L +  +H D+     + T  V   R+G++ Q I   T+ +  S     +G P++ LV+  
Sbjct: 202 LSLVDEHPDAYKQVSDKTLVVVCCRVGTDTQFIELTTLGRCASQADEYYGKPMYALVVPS 261

Query: 350 ETHPVEE-EMLEFY 388
            +   +E  MLE +
Sbjct: 262 PSIAEQESRMLELF 275

[215][TOP]
>UniRef100_Q0D0D2 Diphthine synthase n=1 Tax=Aspergillus terreus NIH2624
           RepID=Q0D0D2_ASPTN
          Length = 239

 Score = 66.2 bits (160), Expect = 1e-09
 Identities = 30/59 (50%), Positives = 42/59 (71%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIE 178
           E W+P S+Y+++K+N  LGLHTL L+DI+VKEP+ ES+ R G+  YEPP +    T  E
Sbjct: 138 ENWKPSSYYDRVKENVQLGLHTLVLVDIKVKEPSLESMAR-GRIVYEPPAFHDRRTMHE 195

[216][TOP]
>UniRef100_Q2FQ45 Probable diphthine synthase n=1 Tax=Methanospirillum hungatei JF-1
           RepID=DPHB_METHJ
          Length = 252

 Score = 65.9 bits (159), Expect = 1e-09
 Identities = 43/125 (34%), Positives = 60/125 (48%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P +  + I  N    LHT+  LDI+                    RYMSV+  IE L 
Sbjct: 142 WFPKTPLDTILANLKQNLHTIVYLDIQEN------------------RYMSVHEGIELLE 183

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           ++ +   DS+       VG AR GS    + AG+ ++L+ VDFG PLH LV+    H +E
Sbjct: 184 KLMEGSTDSI----PLFVGIARAGSNSPVVAAGSSERLKLVDFGPPLHILVVPASLHEIE 239

Query: 368 EEMLE 382
           EE L+
Sbjct: 240 EEYLK 244

[217][TOP]
>UniRef100_Q6XIK1 Similar to Drosophila melanogaster Dph5 (Fragment) n=1
           Tax=Drosophila yakuba RepID=Q6XIK1_DROYA
          Length = 188

 Score = 64.7 bits (156), Expect = 3e-09
 Identities = 29/38 (76%), Positives = 33/38 (86%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESL 115
           ETW+PDSFY+KIK NR   +HTLCLLDI+VKEPT ESL
Sbjct: 150 ETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESL 187

[218][TOP]
>UniRef100_A2SQF6 Probable diphthine synthase n=1 Tax=Methanocorpusculum labreanum Z
           RepID=DPHB_METLZ
          Length = 252

 Score = 64.7 bits (156), Expect = 3e-09
 Identities = 42/125 (33%), Positives = 62/125 (49%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           W P +  E I  N    LHTL  LDI                Q +  RYM ++ A++ LL
Sbjct: 142 WFPMTPIEVISANLKENLHTLVFLDI----------------QKDKERYMKISEAVD-LL 184

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           E + +  D+        VG AR GS + T+ AG  +++++ DFG+PLH L++    H +E
Sbjct: 185 EEQARRVDAGI---PLYVGIARAGSPEPTVHAGNAEEMKAFDFGSPLHILIVPATLHEIE 241

Query: 368 EEMLE 382
            E LE
Sbjct: 242 REYLE 246

[219][TOP]
>UniRef100_Q12XB4 Probable diphthine synthase n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=DPHB_METBU
          Length = 267

 Score = 64.7 bits (156), Expect = 3e-09
 Identities = 46/118 (38%), Positives = 55/118 (46%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y+ IK N   GLHT   LDI                  +   YM+VN A+E LLEVE K 
Sbjct: 153 YDTIKNNIEAGLHTAVFLDID-----------------KDKGYMTVNQAMEILLEVEGKL 195

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEML 379
           G+ V   D   VG AR GS    + A  ++ L     G PLH +VI  E H VE E L
Sbjct: 196 GEGVM-VDRLAVGIARAGSPSPVVKADYIEALRDYYLGGPLHIVVIPAELHFVEAEAL 252

[220][TOP]
>UniRef100_C6LNW7 Diphthine synthase n=1 Tax=Giardia intestinalis ATCC 50581
           RepID=C6LNW7_GIALA
          Length = 290

 Score = 64.3 bits (155), Expect = 4e-09
 Identities = 42/134 (31%), Positives = 69/134 (51%), Gaps = 6/134 (4%)
 Frame = +2

Query: 5   TWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQL 184
           TWRP SF +   +N  L LHTL LL +  KE   +  C  G ++Y  P Y+  N A  Q+
Sbjct: 142 TWRPSSFLDYYLENARLNLHTLVLLQMSTKELDMDLYCEKGLERYSNPYYLLPNQAARQI 201

Query: 185 LEVEQKHGD--SVYGEDTQCVGFARLGSEDQTIVAGTMKQ--LESVD-FGAPLHCLVIVG 349
           L +  ++ D  S    DT  +   R+G++ Q + + T+ +  L++ + +G P++ LV+  
Sbjct: 202 LSLVDEYPDTYSQVSTDTIVIVCCRVGTDTQQLESTTLGRCALQTDEYYGKPMYALVLPS 261

Query: 350 E-THPVEEEMLEFY 388
                 E  MLE +
Sbjct: 262 PIIMEQERRMLELF 275

[221][TOP]
>UniRef100_UPI000069EB72 MGC89330 protein. n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069EB72
          Length = 241

 Score = 62.8 bits (151), Expect = 1e-08
 Identities = 32/70 (45%), Positives = 44/70 (62%), Gaps = 9/70 (12%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFE---------SLCRGGKKQYEPPRY 154
           +TW+P+SFY+KI++NR  G+HTLCLLDI+VKE + E         +LCR G      P  
Sbjct: 138 DTWKPESFYDKIRRNRLSGMHTLCLLDIKVKEQSIENLMNFGEEYNLCRTGTCWCFGPEN 197

Query: 155 MSVNTAIEQL 184
            S +TA  +L
Sbjct: 198 FSWDTAAAEL 207

[222][TOP]
>UniRef100_UPI0001AE7910 Probable diphthine synthase (EC 2.1.1.98) (Diphthamide biosynthesis
           methyltransferase). n=1 Tax=Homo sapiens
           RepID=UPI0001AE7910
          Length = 118

 Score = 62.8 bits (151), Expect = 1e-08
 Identities = 25/38 (65%), Positives = 34/38 (89%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESL 115
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L
Sbjct: 16  DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENL 53

[223][TOP]
>UniRef100_B4DP40 cDNA FLJ60749, moderately similar to Homo sapiens DPH5 homolog
           (DPH5), mRNA n=1 Tax=Homo sapiens RepID=B4DP40_HUMAN
          Length = 119

 Score = 62.8 bits (151), Expect = 1e-08
 Identities = 25/38 (65%), Positives = 34/38 (89%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESL 115
           +TWRP+SF++K+KKNR  G+HTLCLLDI+VKE + E+L
Sbjct: 17  DTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENL 54

[224][TOP]
>UniRef100_A2BJ42 Diphthine synthase n=1 Tax=Hyperthermus butylicus DSM 5456
           RepID=A2BJ42_HYPBU
          Length = 264

 Score = 62.4 bits (150), Expect = 2e-08
 Identities = 44/132 (33%), Positives = 66/132 (50%), Gaps = 5/132 (3%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E ++P S  + ++ NR  GLHT+ LLD+R+ E                 R M+V  A+E 
Sbjct: 141 EGFKPYSTIDVVRNNRRAGLHTMVLLDLRLDE----------------GRAMTVPEAVEL 184

Query: 182 LLEVEQK--HGDSVYGE--DTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVG 349
           LL +E++  H +    E  D   VG AR G ED   +AG  +++ S  +  P H LV+  
Sbjct: 185 LLSLEEELAHEEGWEPELRDAVIVGVARAGLEDGVCIAGRPEEVASASYPPPPHTLVVTA 244

Query: 350 -ETHPVEEEMLE 382
              HP+E E L+
Sbjct: 245 PRLHPMEAEALK 256

[225][TOP]
>UniRef100_B3V612 Diphthine synthase n=1 Tax=uncultured marine group III
           euryarchaeote AD1000-40-D7 RepID=B3V612_9EURY
          Length = 248

 Score = 62.4 bits (150), Expect = 2e-08
 Identities = 41/125 (32%), Positives = 61/125 (48%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           ++P S  +KIK N   G HTL LLDI+  +P  E++            YM+ + A EQ++
Sbjct: 141 YKPTSPIDKIKANMKNGNHTLVLLDIKADQPETEAI------------YMTASQAAEQIM 188

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           E        + GE  +    AR+G EDQ +  G +K L   D G   H LV+    H  E
Sbjct: 189 EA------GLSGE-IKVAAAARVGREDQKLWYGKLKDLAKTDLGKEPHSLVVPSRLHFTE 241

Query: 368 EEMLE 382
           ++ L+
Sbjct: 242 KDFLD 246

[226][TOP]
>UniRef100_B3V675 Diphthine synthase n=1 Tax=uncultured marine group III
           euryarchaeote SAT1000-53-B3 RepID=B3V675_9EURY
          Length = 248

 Score = 62.0 bits (149), Expect = 2e-08
 Identities = 42/125 (33%), Positives = 61/125 (48%)
 Frame = +2

Query: 8   WRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLL 187
           ++P S  +KIK N   G HTL LLDI+  +P  E            P YM+   A EQ++
Sbjct: 141 YKPTSPIDKIKANMKNGNHTLVLLDIKADQPETE------------PIYMTAAQAAEQII 188

Query: 188 EVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVE 367
           E        + GE  +    AR+G EDQ +  G +K L  +D G   H LV+  + H  E
Sbjct: 189 EA------GLSGE-IKVAAAARVGREDQGLWYGKLKDLAKLDLGKEPHSLVVPSKLHFTE 241

Query: 368 EEMLE 382
           ++ L+
Sbjct: 242 KDFLD 246

[227][TOP]
>UniRef100_O27902 Probable diphthine synthase n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=DPHB_METTH
          Length = 264

 Score = 62.0 bits (149), Expect = 2e-08
 Identities = 40/126 (31%), Positives = 54/126 (42%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           + + P S Y  I +N   G H+L LLDI                     RYM+    +  
Sbjct: 139 DNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRN----------------RYMTATEGLRY 182

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           LL+  +K  D     +T  V  AR GSE   + A  +  L   DFG PLHCLV+    H 
Sbjct: 183 LLKASEKLDDGTISGETLAVVIARAGSEKPLVRADKIATLVEEDFGDPLHCLVVPAGLHF 242

Query: 362 VEEEML 379
           +E + L
Sbjct: 243 IEADYL 248

[228][TOP]
>UniRef100_C1V4B8 Diphthine synthase n=1 Tax=Halogeometricum borinquense DSM 11551
           RepID=C1V4B8_9EURY
          Length = 259

 Score = 61.6 bits (148), Expect = 3e-08
 Identities = 43/122 (35%), Positives = 55/122 (45%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S  + I+ NR  GLHTL  LDI+                 +   YMS + A E L + 
Sbjct: 147 PKSVIDSIEANRERGLHTLVYLDIKA----------------DRDEYMSGDYAAEMLADG 190

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                     ED   +  AR GSED  + A  + +L   DFG PLH LVI G+ H VE +
Sbjct: 191 ---------WEDVLGIVVARAGSEDPLVAADRLSELAERDFGDPLHMLVIPGDVHHVEAD 241

Query: 374 ML 379
            L
Sbjct: 242 AL 243

[229][TOP]
>UniRef100_Q97TX8 Probable diphthine synthase n=2 Tax=Sulfolobus solfataricus
           RepID=DPHB_SULSO
          Length = 257

 Score = 61.6 bits (148), Expect = 3e-08
 Identities = 35/120 (29%), Positives = 62/120 (51%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y  IK N+  GLHT+  LD++ ++                   M+ N A++ LL +E++H
Sbjct: 152 YNVIKDNKERGLHTILYLDLKNEKA------------------MTANEALQILLRLEERH 193

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEMLEF 385
             SV  +    +  ARLG +D+ I+A  +++  S DFG   H ++I G  H +E + +++
Sbjct: 194 KKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIPGNLHYMEADAIKW 253

[230][TOP]
>UniRef100_C3N5D1 Probable diphthine synthase n=6 Tax=Sulfolobus islandicus
           RepID=DPHB_SULIA
          Length = 257

 Score = 61.6 bits (148), Expect = 3e-08
 Identities = 36/120 (30%), Positives = 61/120 (50%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y  IK N+  GLHT+  LD++ ++                   M+ N A++ LL +E KH
Sbjct: 152 YNVIKDNKERGLHTILYLDLKSEKA------------------MTANEALQILLRLEDKH 193

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEMLEF 385
             +V  +    +  ARLG +D+ IVA T+++    DFG   H ++I G  H +E + +++
Sbjct: 194 RKNVLSKSDIVIVGARLGCDDEKIVALTVEEATLYDFGNTPHIIIIPGNLHYMEADAIKW 253

[231][TOP]
>UniRef100_Q3IS55 Probable diphthine synthase n=1 Tax=Natronomonas pharaonis DSM 2160
           RepID=DPHB_NATPD
          Length = 266

 Score = 60.5 bits (145), Expect = 6e-08
 Identities = 44/122 (36%), Positives = 55/122 (45%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S  + I  NR  GLHTL  LDI+V         RG    +E   YM+ + A E L E 
Sbjct: 147 PGSVLDTIADNRKRGLHTLVYLDIKVGTGP-----RGPDPDHE--EYMTADYAAELLAE- 198

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                      DT  V  AR GS D  + A  +  L    FG PLH L++ G+ H VE +
Sbjct: 199 ---------DLDTVGVAIARAGSPDPVLAADRLSALADRSFGDPLHLLIVPGDLHVVEHD 249

Query: 374 ML 379
            L
Sbjct: 250 AL 251

[232][TOP]
>UniRef100_B0R4W9 Probable diphthine synthase n=2 Tax=Halobacterium salinarum
           RepID=DPHB_HALS3
          Length = 260

 Score = 60.5 bits (145), Expect = 6e-08
 Identities = 40/122 (32%), Positives = 56/122 (45%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S  + I+ NR  GLHTL  LDI+V  P  +              YM+ + A + L   
Sbjct: 147 PGSVTDTIEANRERGLHTLVYLDIKVDHPRVDG-----------DAYMTASQAADLLA-- 193

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                 + +  D   V  AR G+ D T+ A  +  L   DFG+PLH LV+ G  H +E +
Sbjct: 194 ------TNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGSLHHIERD 247

Query: 374 ML 379
            L
Sbjct: 248 AL 249

[233][TOP]
>UniRef100_C7NPY4 Diphthine synthase n=1 Tax=Halorhabdus utahensis DSM 12940
           RepID=C7NPY4_HALUD
          Length = 263

 Score = 60.1 bits (144), Expect = 8e-08
 Identities = 43/122 (35%), Positives = 55/122 (45%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           PDS  E I+ NR  GLHTL  LDI V+               +   YM  + A   L   
Sbjct: 147 PDSVIETIEANRDRGLHTLVFLDITVES--------------DDGTYMRGDQAASLLA-- 190

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
             KH    +  +   V  AR GS D  + AG +  L  +DFG PLH LV+ G  H +E +
Sbjct: 191 --KH----WRPNALGVVVARAGSPDPVVQAGRLSALAEMDFGGPLHLLVVPGSLHYIERD 244

Query: 374 ML 379
            L
Sbjct: 245 AL 246

[234][TOP]
>UniRef100_C0G2V9 Diphthine synthase n=1 Tax=Natrialba magadii ATCC 43099
           RepID=C0G2V9_NATMA
          Length = 262

 Score = 59.3 bits (142), Expect = 1e-07
 Identities = 40/122 (32%), Positives = 59/122 (48%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S  + I +NR+ GLHT+  LDI+V           G ++ +   YM+ +   + L E 
Sbjct: 147 PASVTDTIDENRADGLHTVVYLDIKV-----------GHERTDEDEYMTADVGADLLAEE 195

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                      D   V  AR GS +  + AGTM +L   +FG PLH LV+ G+ H +E +
Sbjct: 196 YP---------DLVGVVVARAGSPEPLVEAGTMTELADQEFGEPLHLLVVPGDCHLLEAD 246

Query: 374 ML 379
            L
Sbjct: 247 AL 248

[235][TOP]
>UniRef100_Q18JS3 Probable diphthine synthase n=1 Tax=Haloquadratum walsbyi DSM 16790
           RepID=DPHB_HALWD
          Length = 260

 Score = 59.3 bits (142), Expect = 1e-07
 Identities = 41/122 (33%), Positives = 52/122 (42%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           P S  + I  NR  GLHT+  LDI+                     Y+  + A E L   
Sbjct: 147 PTSVTDSIAANRERGLHTVVYLDIKANRD----------------EYLRASDAAEML--- 187

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                 +   ED   +  AR GS D T+ A  +  L   DFG PLH LV+ GE H +EEE
Sbjct: 188 ------ATDLEDMLAIAVARAGSPDPTVRADRLSALAEKDFGDPLHLLVLPGELHHLEEE 241

Query: 374 ML 379
            L
Sbjct: 242 AL 243

[236][TOP]
>UniRef100_C7P4P4 Diphthine synthase n=1 Tax=Halomicrobium mukohataei DSM 12286
           RepID=C7P4P4_HALMD
          Length = 258

 Score = 58.5 bits (140), Expect = 2e-07
 Identities = 41/122 (33%), Positives = 60/122 (49%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEV 193
           PDS  E I  NR  GLHTL  LDI+V +P +E     G++++     M+ + A   L + 
Sbjct: 147 PDSVVETITANRERGLHTLVYLDIKVDDPHWE-----GEQEF-----MTADHAAGLLAD- 195

Query: 194 EQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEE 373
                      DT  V  AR GS +  + A ++  L   D+G PLH LV+  + H +E +
Sbjct: 196 ---------HFDTLGVVVARAGSANPVVEADSLDALADGDYGGPLHLLVVPADLHEMERD 246

Query: 374 ML 379
            L
Sbjct: 247 AL 248

[237][TOP]
>UniRef100_B3T4A8 Diphthine synthase n=2 Tax=environmental samples RepID=B3T4A8_9ARCH
          Length = 345

 Score = 58.2 bits (139), Expect = 3e-07
 Identities = 36/118 (30%), Positives = 54/118 (45%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y  I KN   GLH++ LL+    E  F                +    AI  L++VE++ 
Sbjct: 145 YTSIFKNLIQGLHSVILLEYNQDENYF----------------LDPKDAISSLMDVEKEQ 188

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEML 379
             +V   DT  +  +R+G E Q I +G    L  VDFG P H ++I G+ H  E + +
Sbjct: 189 KRNVVNNDTFAIVASRIGFETQKITSGKFSNLLKVDFGEPPHSIIITGKLHFTESDAI 246

[238][TOP]
>UniRef100_B9LV13 Probable diphthine synthase n=1 Tax=Halorubrum lacusprofundi ATCC
           49239 RepID=DPHB_HALLT
          Length = 265

 Score = 57.0 bits (136), Expect = 6e-07
 Identities = 44/123 (35%), Positives = 57/123 (46%), Gaps = 1/123 (0%)
 Frame = +2

Query: 14  PDSFYEKIKKNRSLGLHTLCLLDIRVKE-PTFESLCRGGKKQYEPPRYMSVNTAIEQLLE 190
           P S  + I+ NR  GLHT+  LDI+V   PT      G    +E   YM+ + A   L +
Sbjct: 147 PGSVIDTIEANRERGLHTVVYLDIKVGTGPT------GPDPDHE--EYMTADVAAGLLAD 198

Query: 191 VEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEE 370
                      ED   V  AR GS D  + A  +  L   +FG PLH LVI G+ H VE 
Sbjct: 199 G---------WEDALAVVVARAGSPDAVVAADRLSALADREFGDPLHLLVIPGDLHHVEA 249

Query: 371 EML 379
           + L
Sbjct: 250 DAL 252

[239][TOP]
>UniRef100_A3DLV7 Probable diphthine synthase n=1 Tax=Staphylothermus marinus F1
           RepID=DPHB_STAMF
          Length = 267

 Score = 56.2 bits (134), Expect = 1e-06
 Identities = 36/129 (27%), Positives = 68/129 (52%), Gaps = 1/129 (0%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           E ++P S  E I  N    LHTL LLD++++E                 + M++  A++ 
Sbjct: 141 EYFKPYSTIETIYDNLDRNLHTLLLLDLKIEEN----------------KAMTIPEAVDI 184

Query: 182 LLEVEQKHG-DSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETH 358
           L++++++   +++ G     VG A+LGS  + IVA  +  L++  +  P H ++IV + H
Sbjct: 185 LIDLDERGVLENIIG-----VGLAQLGSSMEKIVADRLADLKNYTYPPPPHSIIIVAKPH 239

Query: 359 PVEEEMLEF 385
           P+E + L +
Sbjct: 240 PIELDNLHY 248

[240][TOP]
>UniRef100_UPI000013EED4 UPI000013EED4 related cluster n=1 Tax=Homo sapiens
           RepID=UPI000013EED4
          Length = 123

 Score = 55.5 bits (132), Expect = 2e-06
 Identities = 24/42 (57%), Positives = 30/42 (71%)
 Frame = -3

Query: 348 PTITRQCNGAPKSTLSSCFIVPATIVWSSEPSRAKPTHCVSS 223
           P + ++CNG+PKST+  C  VPA I WSS P+ AKPT  VSS
Sbjct: 17  PVMIKECNGSPKSTVHICLKVPAAIFWSSAPTLAKPTQSVSS 58

[241][TOP]
>UniRef100_Q9NXN7 CDNA FLJ20139 fis, clone COL07179 n=1 Tax=Homo sapiens
           RepID=Q9NXN7_HUMAN
          Length = 123

 Score = 55.5 bits (132), Expect = 2e-06
 Identities = 24/42 (57%), Positives = 30/42 (71%)
 Frame = -3

Query: 348 PTITRQCNGAPKSTLSSCFIVPATIVWSSEPSRAKPTHCVSS 223
           P + ++CNG+PKST+  C  VPA I WSS P+ AKPT  VSS
Sbjct: 17  PVMIKECNGSPKSTVHICLKVPAAIFWSSAPTLAKPTQSVSS 58

[242][TOP]
>UniRef100_B8D6P0 Diphthine synthase n=1 Tax=Desulfurococcus kamchatkensis 1221n
           RepID=B8D6P0_DESK1
          Length = 257

 Score = 55.1 bits (131), Expect = 2e-06
 Identities = 38/128 (29%), Positives = 61/128 (47%)
 Frame = +2

Query: 2   ETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQ 181
           ++++P S  + I  N    LHTL LLD+R++E                   MS+  AI+ 
Sbjct: 142 DSFKPYSVIKTIYDNLGRNLHTLVLLDLRLEEGLA----------------MSIPEAIDI 185

Query: 182 LLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHP 361
           L E+++K        +   +G ARLG   + I AG + +L+   +  P H L+I    HP
Sbjct: 186 LTELDEKQQLM----NQISIGVARLGWSSEVIRAGRLIELKRYSYPPPPHSLIIAARLHP 241

Query: 362 VEEEMLEF 385
           +E E L +
Sbjct: 242 IELESLRY 249

[243][TOP]
>UniRef100_O29866 Probable diphthine synthase n=1 Tax=Archaeoglobus fulgidus
           RepID=DPHB_ARCFU
          Length = 251

 Score = 54.7 bits (130), Expect = 3e-06
 Identities = 35/116 (30%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
 Frame = +2

Query: 35  IKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKHGDS 214
           IK NRS+  HTL  LD+                    P  M++  A+E L+       + 
Sbjct: 146 IKANRSIDAHTLLFLDLH-------------------PEPMTIGHAVENLI------AED 180

Query: 215 VYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGET-HPVEEEML 379
              +D   VG AR GS ++ +    ++ L+ +DFG PLH +V++ +T H +E E L
Sbjct: 181 AQMKDLYAVGIARAGSGEEVVKCDRLENLKKIDFGKPLHVMVVLAKTLHFMEFECL 236

[244][TOP]
>UniRef100_Q8TXC7 Probable diphthine synthase n=1 Tax=Methanopyrus kandleri
           RepID=DPHB_METKA
          Length = 263

 Score = 53.5 bits (127), Expect = 7e-06
 Identities = 31/106 (29%), Positives = 50/106 (47%)
 Frame = +2

Query: 26  YEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKH 205
           Y+ ++ NR  GLHTL LL++                  E   ++SV  A   LLE+E++ 
Sbjct: 149 YDVLESNRQAGLHTLFLLEVA-----------------EDGEFVSVADAARYLLEIEREE 191

Query: 206 GDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVI 343
           G  V       +   RLG ED+ +  GT+++L   + G P   L++
Sbjct: 192 GRGVLDPSDLAIAVVRLGFEDELVAWGTLEELSDWEPGEPPQALIL 237