[UP]
BLASTX 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= AV527029 APZ26h07R (439 letters) Database: uniref100 9,526,577 sequences; 3,332,566,763 total letters Searching..................................................done significant alignments:[graphical|details] UniRef100_Q94BQ2 Putative 26S proteasome AAA-ATPase subunit RPT6... 262 8e-69 UniRef100_Q9C5U3 AtSUG1 protein n=2 Tax=Arabidopsis thaliana Rep... 235 1e-60 UniRef100_B2BXU8 Putative uncharacterized protein n=1 Tax=Capsel... 221 1e-56 UniRef100_B9STQ0 26S protease regulatory subunit, putative n=1 T... 203 5e-51 UniRef100_B9HVM8 Predicted protein n=2 Tax=Populus trichocarpa R... 200 4e-50 UniRef100_B9HJP6 Predicted protein n=1 Tax=Populus trichocarpa R... 197 3e-49 UniRef100_C6T7G4 Putative uncharacterized protein n=1 Tax=Glycin... 194 3e-48 UniRef100_A7P5J9 Chromosome chr4 scaffold_6, whole genome shotgu... 194 3e-48 UniRef100_Q9SCD6 26S proteasome subunit 8 (Tat binding protein) ... 191 2e-47 UniRef100_B4G124 26S protease regulatory subunit 8 n=1 Tax=Zea m... 190 4e-47 UniRef100_B4G109 Putative uncharacterized protein n=1 Tax=Zea ma... 190 4e-47 UniRef100_Q7GCH3 Os02g0205300 protein n=3 Tax=Oryza sativa RepID... 190 4e-47 UniRef100_C5XXY0 Putative uncharacterized protein Sb04g007170 n=... 190 5e-47 UniRef100_C6TE07 Putative uncharacterized protein n=1 Tax=Glycin... 189 1e-46 UniRef100_B8A063 Putative uncharacterized protein n=1 Tax=Zea ma... 189 1e-46 UniRef100_B4FSF1 Putative uncharacterized protein n=1 Tax=Zea ma... 189 1e-46 UniRef100_A7P7P4 Chromosome chr9 scaffold_7, whole genome shotgu... 188 2e-46 UniRef100_Q9SST5 TAT-binding protein homolog n=1 Tax=Matricaria ... 187 2e-46 UniRef100_Q9FNU8 26S proteasome RPT6a subunit n=1 Tax=Dactylis g... 186 7e-46 UniRef100_C0PS92 Putative uncharacterized protein n=1 Tax=Picea ... 183 6e-45 UniRef100_Q9M613 26S proteasome regulatory subunit 8 n=1 Tax=Pin... 181 2e-44 UniRef100_B5M1X7 Putative 26S proteasome AAA-ATPase subunit RPT6... 175 1e-42 UniRef100_A9TJJ6 26S proteasome regulatory complex, ATPase RPT6 ... 173 5e-42 UniRef100_Q42271 Mating-type domain (Fragment) n=1 Tax=Arabidops... 171 3e-41 UniRef100_Q4RG45 Chromosome 2 SCAF15106, whole genome shotgun se... 157 3e-37 UniRef100_UPI00016E5B3E UPI00016E5B3E related cluster n=1 Tax=Ta... 157 3e-37 UniRef100_B4M1V5 GJ19383 n=1 Tax=Drosophila virilis RepID=B4M1V5... 157 3e-37 UniRef100_B4JLM1 GH11847 n=1 Tax=Drosophila grimshawi RepID=B4JL... 157 3e-37 UniRef100_B3N0G6 GF21725 n=1 Tax=Drosophila ananassae RepID=B3N0... 156 6e-37 UniRef100_Q7XYC4 26S proteasome ATPase subunit (Fragment) n=1 Ta... 156 8e-37 UniRef100_Q29I61 GA13327 n=1 Tax=Drosophila pseudoobscura pseudo... 156 8e-37 UniRef100_UPI00015B4FB0 PREDICTED: similar to GA13327-PA n=1 Tax... 155 1e-36 UniRef100_B5G0X8 Putative proteasome 26S subunit ATPase 5 varian... 155 1e-36 UniRef100_A4RTZ7 Predicted protein n=1 Tax=Ostreococcus lucimari... 155 1e-36 UniRef100_B8RJ84 26S protease regulatory subunit 8 (Fragment) n=... 155 1e-36 UniRef100_B0WSW1 26S protease regulatory subunit 8 n=1 Tax=Culex... 155 1e-36 UniRef100_UPI0000610311 26S protease regulatory subunit 8 (Prote... 155 2e-36 UniRef100_C3KHX1 26S protease regulatory subunit 8 n=1 Tax=Anopl... 155 2e-36 UniRef100_Q16FL0 26S protease regulatory subunit n=1 Tax=Aedes a... 155 2e-36 UniRef100_UPI0000F2C086 PREDICTED: similar to mSUG1 protein n=1 ... 154 2e-36 UniRef100_UPI0000E24A07 PREDICTED: similar to mSUG1 protein isof... 154 2e-36 UniRef100_UPI0000E24A04 PREDICTED: similar to mSUG1 protein isof... 154 2e-36 UniRef100_UPI0000D9E44A PREDICTED: similar to for proteasomal AT... 154 2e-36 UniRef100_A8K3Z3 cDNA FLJ75514, highly similar to S.scrofa putat... 154 2e-36 UniRef100_P62195 26S protease regulatory subunit 8 n=7 Tax=Euthe... 154 2e-36 UniRef100_Q6AZC1 Proteasome (Prosome, macropain) 26S subunit, AT... 154 2e-36 UniRef100_Q8K1K2 Protease (Prosome, macropain) 26S subunit, ATPa... 154 2e-36 UniRef100_C5Z5K6 Putative uncharacterized protein Sb10g023320 n=... 154 2e-36 UniRef100_Q5R9X8 Putative uncharacterized protein DKFZp469N241 n... 154 2e-36 UniRef100_Q59GS3 Proteasome 26S ATPase subunit 5 variant (Fragme... 154 2e-36 UniRef100_B7Q2Y6 26S proteasome regulatory complex, ATPase RPT6,... 154 3e-36 UniRef100_B4PZ23 GE17917 n=4 Tax=melanogaster subgroup RepID=B4P... 154 3e-36 UniRef100_UPI00005137B5 PREDICTED: similar to 26S protease regul... 154 4e-36 UniRef100_A7RGH4 Predicted protein n=1 Tax=Nematostella vectensi... 154 4e-36 UniRef100_B4N1I1 GK16292 n=1 Tax=Drosophila willistoni RepID=B4N... 153 5e-36 UniRef100_O18413 26S protease regulatory subunit 8 n=1 Tax=Droso... 153 5e-36 UniRef100_C1BLC7 26S protease regulatory subunit 8 n=1 Tax=Osmer... 153 7e-36 UniRef100_Q69X47 Os06g0600100 protein n=1 Tax=Oryza sativa Japon... 152 9e-36 UniRef100_Q7PTA8 AGAP007243-PA n=1 Tax=Anopheles gambiae RepID=Q... 152 9e-36 UniRef100_B5XG54 26S protease regulatory subunit 8 n=1 Tax=Salmo... 152 1e-35 UniRef100_B4L8N1 GI14329 n=1 Tax=Drosophila mojavensis RepID=B4L... 152 1e-35 UniRef100_UPI0000D571F0 PREDICTED: similar to GA13327-PA n=1 Tax... 151 2e-35 UniRef100_Q6AZU7 Putative uncharacterized protein n=1 Tax=Xenopu... 151 2e-35 UniRef100_B8B4C0 Putative uncharacterized protein n=1 Tax=Oryza ... 151 2e-35 UniRef100_P46470 26S protease regulatory subunit 8 n=1 Tax=Xenop... 151 2e-35 UniRef100_UPI000069E3BD Hypothetical protein MGC75584. n=1 Tax=X... 151 2e-35 UniRef100_Q6P380 Putative uncharacterized protein MGC75584 n=1 T... 151 2e-35 UniRef100_UPI000186CC3A 26S protease regulatory subunit, putativ... 150 3e-35 UniRef100_C1BSX5 26S protease regulatory subunit 8 n=1 Tax=Lepeo... 150 4e-35 UniRef100_C1E3S9 Proteasomal ATPase n=1 Tax=Micromonas sp. RCC29... 149 7e-35 UniRef100_B5XCM1 26S protease regulatory subunit 8 n=1 Tax=Salmo... 149 9e-35 UniRef100_A9VBE8 Predicted protein n=1 Tax=Monosiga brevicollis ... 149 9e-35 UniRef100_B5DXM1 GA26607 n=1 Tax=Drosophila pseudoobscura pseudo... 149 1e-34 UniRef100_P54814 26S protease regulatory subunit 8 n=1 Tax=Mandu... 149 1e-34 UniRef100_Q6GQB7 MGC80185 protein n=1 Tax=Xenopus laevis RepID=Q... 148 2e-34 UniRef100_Q5XUC0 Putative 26S protease regulatory subunit 8 n=1 ... 148 2e-34 UniRef100_UPI00017938B5 PREDICTED: similar to putative 26S prote... 147 3e-34 UniRef100_UPI0000E47D13 PREDICTED: hypothetical protein n=1 Tax=... 147 4e-34 UniRef100_B3MT99 GF23322 n=1 Tax=Drosophila ananassae RepID=B3MT... 147 4e-34 UniRef100_B4G5Q0 GL24409 n=1 Tax=Drosophila persimilis RepID=B4G... 146 6e-34 UniRef100_Q4PGD0 Putative uncharacterized protein n=1 Tax=Ustila... 145 1e-33 UniRef100_B4HZT2 GM12144 n=1 Tax=Drosophila sechellia RepID=B4HZ... 145 1e-33 UniRef100_B4R279 GD16958 n=1 Tax=Drosophila simulans RepID=B4R27... 145 2e-33 UniRef100_Q9VA54 CG2241 n=1 Tax=Drosophila melanogaster RepID=Q9... 144 3e-33 UniRef100_B4LVX6 GJ23001 n=1 Tax=Drosophila virilis RepID=B4LVX6... 144 3e-33 UniRef100_B3P565 GG11925 n=1 Tax=Drosophila erecta RepID=B3P565_... 144 3e-33 UniRef100_B4PMJ2 GE23375 n=1 Tax=Drosophila yakuba RepID=B4PMJ2_... 144 4e-33 UniRef100_B6JZU1 19S proteasome regulatory subunit Rpt6 n=1 Tax=... 144 4e-33 UniRef100_P41836 26S protease regulatory subunit 8 homolog n=1 T... 144 4e-33 UniRef100_C1M2P7 26S protease regulatory subunit, putative n=1 T... 143 7e-33 UniRef100_UPI0000E24A03 PREDICTED: similar to mSUG1 protein isof... 142 9e-33 UniRef100_Q5DA11 SJCHGC09272 protein n=1 Tax=Schistosoma japonic... 142 9e-33 UniRef100_C3ZR59 Putative uncharacterized protein n=1 Tax=Branch... 142 9e-33 UniRef100_P34124 26S protease regulatory subunit 8 n=1 Tax=Dicty... 142 1e-32 UniRef100_B6KBS0 26S protease regulatory subunit 8, putative n=3... 142 2e-32 UniRef100_C1N3T3 Proteasomal ATPase n=1 Tax=Micromonas pusilla C... 141 3e-32 UniRef100_B4K9I5 GI10644 n=1 Tax=Drosophila mojavensis RepID=B4K... 141 3e-32 UniRef100_A8P5I4 Putative uncharacterized protein n=1 Tax=Coprin... 140 4e-32 UniRef100_Q25544 26S protease regulatory subunit 8 homolog n=1 T... 140 6e-32 UniRef100_A8QGP0 26S protease regulatory subunit 8, putative (Fr... 139 1e-31 UniRef100_B0DLC3 26S proteasome regulatory complex, ATPase RPT6 ... 138 2e-31 UniRef100_B8BTH7 26S proteasome ATPase regulatory subunit 6 n=1 ... 138 2e-31 UniRef100_B7G9A4 Predicted protein n=1 Tax=Phaeodactylum tricorn... 137 5e-31 UniRef100_A8JHL1 26S proteasome regulatory subunit n=1 Tax=Chlam... 135 1e-30 UniRef100_UPI000013C62B PREDICTED: similar to mSUG1 protein isof... 135 2e-30 UniRef100_UPI000180B188 PREDICTED: similar to MGC80185 protein n... 134 3e-30 UniRef100_Q01D39 26S proteasome regulatory complex, ATPase RPT4 ... 134 3e-30 UniRef100_A9NI59 26S proteasome subunit RPT6 (Fragment) n=1 Tax=... 133 5e-30 UniRef100_Q9XTT9 Protein Y49E10.1, confirmed by transcript evide... 133 7e-30 UniRef100_A3LTW6 Protease regulatory subunit 8 homolog (SUG1 pro... 133 7e-30 UniRef100_Q22UL9 26S proteasome subunit P45 family protein n=1 T... 132 9e-30 UniRef100_C5LGH0 Tat-binding protein, putative n=1 Tax=Perkinsus... 132 9e-30 UniRef100_C5KUG8 Tat-binding protein, putative n=1 Tax=Perkinsus... 132 9e-30 UniRef100_A8XE05 C. briggsae CBR-RPT-6 protein n=1 Tax=Caenorhab... 132 9e-30 UniRef100_A8PUF7 Putative uncharacterized protein n=1 Tax=Malass... 132 9e-30 UniRef100_UPI000151B88D hypothetical protein PGUG_03744 n=1 Tax=... 132 1e-29 UniRef100_A5DKE3 Putative uncharacterized protein n=1 Tax=Pichia... 132 1e-29 UniRef100_Q6BUL5 DEHA2C09658p n=1 Tax=Debaryomyces hansenii RepI... 131 2e-29 UniRef100_Q6C8T1 YALI0D17204p n=1 Tax=Yarrowia lipolytica RepID=... 130 3e-29 UniRef100_Q5KAP2 Endopeptidase, putative n=1 Tax=Filobasidiella ... 130 3e-29 UniRef100_B2ASW6 Predicted CDS Pa_6_11440 n=1 Tax=Podospora anse... 130 5e-29 UniRef100_Q4Z6Y1 Tat-binding protein homolog, putative n=1 Tax=P... 130 6e-29 UniRef100_Q7RKK4 Tat-binding protein homolog n=1 Tax=Plasmodium ... 128 2e-28 UniRef100_A5K8Z1 26S protease regulatory subunit 8, putative n=1... 128 2e-28 UniRef100_Q59YB2 Likely 26S proteasome regulatory particle ATPas... 128 2e-28 UniRef100_Q59Y56 Likely 26S proteasome regulatory particle ATPas... 128 2e-28 UniRef100_C5M4W2 26S protease regulatory subunit 8 n=1 Tax=Candi... 128 2e-28 UniRef100_C4YKF8 26S protease regulatory subunit 8 n=1 Tax=Candi... 128 2e-28 UniRef100_B9WCF2 26S protease regulatory subunit, putative n=1 T... 128 2e-28 UniRef100_A5DZ08 26S protease regulatory subunit 8 n=1 Tax=Lodde... 128 2e-28 UniRef100_B3LDD0 Tat-binding protein homolog, putative n=1 Tax=P... 125 2e-27 UniRef100_Q0V0F4 Putative uncharacterized protein n=1 Tax=Phaeos... 125 2e-27 UniRef100_A4RKV2 Putative uncharacterized protein n=1 Tax=Magnap... 125 2e-27 UniRef100_UPI000023E36D hypothetical protein FG01605.1 n=1 Tax=G... 124 2e-27 UniRef100_C4QVY9 One of six ATPases of the 19S regulatory partic... 124 2e-27 UniRef100_B2WEX0 26S protease regulatory subunit 8 n=1 Tax=Pyren... 124 2e-27 UniRef100_A1C8Z9 Proteasome regulatory particle subunit Rpt6, pu... 124 3e-27 UniRef100_Q8I4U5 Tat-binding protein homolog n=1 Tax=Plasmodium ... 124 4e-27 UniRef100_C7YW17 26S proteasome regulatory complex, ATPase RPT6 ... 124 4e-27 UniRef100_A8IKN2 Proteasome 19S regulatory particle (Fragment) n... 123 6e-27 UniRef100_C5E1M9 ZYRO0G22330p n=1 Tax=Zygosaccharomyces rouxii C... 123 6e-27 UniRef100_A1D9F7 Proteasome regulatory particle subunit Rpt6, pu... 123 6e-27 UniRef100_B4JY00 GH14117 n=1 Tax=Drosophila grimshawi RepID=B4JY... 123 7e-27 UniRef100_A0DM44 Chromosome undetermined scaffold_56, whole geno... 122 9e-27 UniRef100_C5FGW9 26S protease regulatory subunit 8 n=1 Tax=Micro... 122 9e-27 UniRef100_Q9P665 Probable 26S protease subunit RPT6 n=1 Tax=Neur... 122 2e-26 UniRef100_Q0CU76 26S protease regulatory subunit 8 n=1 Tax=Asper... 122 2e-26 UniRef100_C1G0B0 26S protease regulatory subunit 8 n=3 Tax=Parac... 122 2e-26 UniRef100_B8MA44 Proteasome regulatory particle subunit Rpt6, pu... 122 2e-26 UniRef100_B6QGM9 Proteasome regulatory particle subunit Rpt6, pu... 122 2e-26 UniRef100_B6QGM8 Proteasome regulatory particle subunit Rpt6, pu... 122 2e-26 UniRef100_A2R2B7 Complex: RPT6 is a protein of the 19S particle ... 122 2e-26 UniRef100_C5GY97 26S protease regulatory subunit 8 n=2 Tax=Ajell... 121 2e-26 UniRef100_C0NYT2 26S protease regulatory subunit n=2 Tax=Ajellom... 121 2e-26 UniRef100_B8NZ22 Proteasome regulatory particle subunit Rpt6, pu... 121 2e-26 UniRef100_A6SNP7 26S protease regulatory subunit 8 n=1 Tax=Botry... 121 2e-26 UniRef100_A6RDH4 26S protease regulatory subunit 8 n=1 Tax=Ajell... 121 2e-26 UniRef100_A3E3L4 ATP-dependent 26S proteasome regulatory subunit... 120 4e-26 UniRef100_C8VCB3 Putative uncharacterized protein n=2 Tax=Emeric... 120 4e-26 UniRef100_A7TLA9 Putative uncharacterized protein n=1 Tax=Vander... 120 4e-26 UniRef100_A0C4C1 Chromosome undetermined scaffold_149, whole gen... 120 6e-26 UniRef100_A0BTJ0 Chromosome undetermined scaffold_127, whole gen... 120 6e-26 UniRef100_C7GS25 Rpt6p n=1 Tax=Saccharomyces cerevisiae JAY291 R... 119 8e-26 UniRef100_Q01939 26S protease regulatory subunit 8 homolog n=5 T... 119 8e-26 UniRef100_Q750J4 AGL043Cp n=1 Tax=Eremothecium gossypii RepID=Q7... 119 1e-25 UniRef100_B6H2X7 Pc13g05760 protein n=1 Tax=Penicillium chrysoge... 119 1e-25 UniRef100_A3FPS8 26s protease regulatory subunit 8, putative n=2... 118 2e-25 UniRef100_C4JGT1 26S protease regulatory subunit 8 n=3 Tax=Onyge... 118 2e-25 UniRef100_Q6FVR5 Strain CBS138 chromosome D complete sequence n=... 117 3e-25 UniRef100_A0DNH0 Chromosome undetermined scaffold_58, whole geno... 117 4e-25 UniRef100_C5DGA9 KLTH0D03806p n=1 Tax=Lachancea thermotolerans C... 117 4e-25 UniRef100_B6ABG9 26S protease regulatory subunit 8, putative n=1... 116 7e-25 UniRef100_A7E8L3 Putative uncharacterized protein n=1 Tax=Sclero... 116 7e-25 UniRef100_Q6CXY1 KLLA0A04752p n=1 Tax=Kluyveromyces lactis RepID... 116 9e-25 UniRef100_A7AX69 Tat-binding protein-like protein n=1 Tax=Babesi... 114 3e-24 UniRef100_UPI0000E24A05 PREDICTED: similar to mSUG1 protein isof... 113 6e-24 UniRef100_Q4UFM6 26S proteasome ATPase subunit (Rpt6A homologue)... 111 3e-23 UniRef100_Q4N3U5 26S proteasome regulatory subunit, putative n=1... 110 4e-23 UniRef100_Q4Q0X8 Proteasome regulatory ATPase subunit n=1 Tax=Le... 110 5e-23 UniRef100_A4IE38 Proteasome regulatory ATPase subunit n=1 Tax=Le... 110 5e-23 UniRef100_A4HPV3 Proteasome regulatory ATPase subunit n=1 Tax=Le... 110 5e-23 UniRef100_Q4DZM5 Proteasome regulatory ATPase subunit, putative ... 109 8e-23 UniRef100_Q8MXF1 Putative uncharacterized protein n=2 Tax=Caenor... 108 2e-22 UniRef100_UPI0001867FA7 hypothetical protein BRAFLDRAFT_128520 n... 105 2e-21 UniRef100_A8XXK8 Putative uncharacterized protein n=1 Tax=Caenor... 103 5e-21 UniRef100_B0E8W6 26S protease regulatory subunit, putative n=1 T... 102 2e-20 UniRef100_C4Y4F8 Putative uncharacterized protein n=1 Tax=Clavis... 102 2e-20 UniRef100_Q9NC95 Proteasome regulatory ATPase subunit 6 n=1 Tax=... 100 7e-20 UniRef100_D0A4A2 Proteasome regulatory ATPase subunit 6 (19s pro... 100 7e-20 UniRef100_C4M8D7 26S protease regulatory subunit, putative n=1 T... 99 1e-19 UniRef100_B1N5Y7 26S protease regulatory subunit 8, putative (Fr... 99 1e-19 UniRef100_B1N4G1 26S protease regulatory subunit, putative n=1 T... 99 1e-19 UniRef100_C9SL29 Proteasome 19S regulatory particle n=1 Tax=Vert... 96 1e-18 UniRef100_C5X5Y0 Putative uncharacterized protein Sb02g011960 n=... 94 4e-18 UniRef100_C4V7P0 Putative uncharacterized protein n=1 Tax=Nosema... 94 4e-18 UniRef100_B0E957 26S protease regulatory subunit, putative n=1 T... 94 5e-18 UniRef100_A8PCB9 26S protease regulatory subunit 8, putative n=1... 94 6e-18 UniRef100_Q8SQK0 26S protease regulatory subunit 8 homolog n=1 T... 94 6e-18 UniRef100_A2F9G0 Putative uncharacterized protein n=1 Tax=Tricho... 84 4e-15 UniRef100_A9CTF1 19S-PA700 proteasome regulatory particle subuni... 77 6e-13 UniRef100_A8BJ82 26S protease regulatory subunit 8 n=1 Tax=Giard... 70 7e-11 UniRef100_C6LVX2 26S protease regulatory subunit 8 n=1 Tax=Giard... 69 2e-10 UniRef100_B7FK03 Putative uncharacterized protein n=1 Tax=Medica... 67 8e-10 UniRef100_Q98S38 26S proteasome SU n=1 Tax=Guillardia theta RepI... 62 2e-08 UniRef100_A9BL61 PrsS8 n=1 Tax=Cryptophyta RepID=A9BL61_9CRYP 62 2e-08 UniRef100_B2R8F2 cDNA, FLJ93870 n=1 Tax=Homo sapiens RepID=B2R8F... 60 1e-07 UniRef100_UPI0000E24A06 PREDICTED: similar to mSUG1 protein isof... 59 2e-07 UniRef100_Q5R969 Putative uncharacterized protein DKFZp459F0926 ... 58 3e-07 UniRef100_Q86G67 26S proteasome regulatory subunit n=1 Tax=Derma... 57 6e-07 UniRef100_O57940 Proteasome-activating nucleotidase n=1 Tax=Pyro... 56 1e-06 UniRef100_Q8U4H3 Proteasome-activating nucleotidase n=1 Tax=Pyro... 56 1e-06 UniRef100_Q45VP5 26S protease regulatory subunit (Fragment) n=1 ... 54 4e-06 UniRef100_Q6P307 Proteasome (Prosome, macropain) 26S subunit, AT... 54 5e-06 UniRef100_Q6DRD2 26S protease regulatory subunit S10B n=1 Tax=Da... 54 7e-06 UniRef100_Q1LUG7 Proteasome (Prosome, macropain) 26S subunit, AT... 54 7e-06 UniRef100_UPI000155C364 PREDICTED: similar to conserved ATPase d... 53 9e-06