HUGE ppi

A Database of protein-protein interactions between large proteins
(HUGE:Human Unidentified Gene-Encoded Large Proteins Analyzed by Kazusa cDNA Project)

Thank you for your interest in our protein-protein interaction database

The HUGE ppi protein database has been created to publicize the fruitsof our Human cDNA project at the Kazusa DNA Research Institute. Large proteins have multiple domains potentially capable of bindingmany kinds of partners. It is conceivable, therefore, that such proteinscould function as an intricate framework of assembly protein complexes.To comprehensively study protein-protein interactions between large KIAAproteins, we have constructed a library composed of KIAA cDNA clonesbased on prior functional classifications done in sillico. Our representativelibrary should be a very useful resource for detecting previously unidentifiedinteractions because it complements conventional expression libraries,which seldom contain large cDNAs.

METHODS


REFERENCES

• Manabu Nakayama, Reiko Kikuno, and Osamu Ohara
  Protein-Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs.
  Genome Research (2002) 12: 1773-1784
  
  
  

DISCLAIMERS

ACKNOWLEDGMENTS

• List of protein-protein interaction pairs
• Description of the experimental result of two-hybrid screening

• Direct access to a table of interest
  

  Enter KIAA number:
  Bait Prey Both
  (e.g, KIAA0319)

• Supplemental table
• Bibliography