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[1][TOP]
>UniRef100_B9HKV5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HKV5_POPTR
          Length = 443

 Score =  354 bits (908), Expect = 3e-96
 Identities = 176/194 (90%), Positives = 186/194 (95%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GKLLLKVPPTL+FVMDGEMPDYLLAKDLILQIIGEI+VAGATYKS
Sbjct: 146 ATGIGNTDAGFVLGTGKLLLKVPPTLKFVMDGEMPDYLLAKDLILQIIGEISVAGATYKS 205

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G+TVESL MEERMTLCNMV+EAGGKNGV+PPDS T+KYLE KTS+PYE VYSD QA
Sbjct: 206 MEFAGTTVESLTMEERMTLCNMVIEAGGKNGVVPPDSTTFKYLEDKTSLPYEPVYSDAQA 265

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFL+EYRFDVTKLEPLVAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDFMAAAKVF
Sbjct: 266 RFLTEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFMAAAKVF 325

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKV+VPTFL
Sbjct: 326 LAS-GKKVRVPTFL 338

[2][TOP]
>UniRef100_B9SQS5 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS5_RICCO
          Length = 510

 Score =  352 bits (904), Expect = 9e-96
 Identities = 178/194 (91%), Positives = 187/194 (96%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEI+V+GATYKS
Sbjct: 213 ATGIGNTDAGFVLGTGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEISVSGATYKS 272

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG+TVESLNMEERMTLCNMVVEAGGKNGVIP DS T+KYLE KTSVP+E VYSD++A
Sbjct: 273 MEFVGTTVESLNMEERMTLCNMVVEAGGKNGVIPSDSTTFKYLEDKTSVPFEPVYSDEKA 332

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFDV+KLEPLVAKPHSPDN ALARECKDVKI+RVYIGSCTGGKTEDFMAAAKVF
Sbjct: 333 RFLSEYRFDVSKLEPLVAKPHSPDNCALARECKDVKIDRVYIGSCTGGKTEDFMAAAKVF 392

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 393 LAS-GKKVKVPTFL 405

[3][TOP]
>UniRef100_UPI0001983BAD PREDICTED: similar to Os02g0125100 n=1 Tax=Vitis vinifera
           RepID=UPI0001983BAD
          Length = 508

 Score =  350 bits (899), Expect = 4e-95
 Identities = 176/194 (90%), Positives = 185/194 (95%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GK+LLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEI+V+GATYKS
Sbjct: 211 ATGIGNTDAGFVLGTGKILLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEISVSGATYKS 270

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P DS T+KYLE KT VPYE VYSD+QA
Sbjct: 271 MEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYLEDKTDVPYEPVYSDEQA 330

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFDV+KLEPLVAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 331 RFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 390

Query: 543 LASGGKKVKVPTFL 584
            AS GKKVKVPTFL
Sbjct: 391 HAS-GKKVKVPTFL 403

[4][TOP]
>UniRef100_A7QRJ3 Chromosome chr8 scaffold_150, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7QRJ3_VITVI
          Length = 424

 Score =  350 bits (899), Expect = 4e-95
 Identities = 176/194 (90%), Positives = 185/194 (95%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GK+LLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEI+V+GATYKS
Sbjct: 165 ATGIGNTDAGFVLGTGKILLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEISVSGATYKS 224

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P DS T+KYLE KT VPYE VYSD+QA
Sbjct: 225 MEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYLEDKTDVPYEPVYSDEQA 284

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFDV+KLEPLVAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 285 RFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 344

Query: 543 LASGGKKVKVPTFL 584
            AS GKKVKVPTFL
Sbjct: 345 HAS-GKKVKVPTFL 357

[5][TOP]
>UniRef100_B9HSU8 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HSU8_POPTR
          Length = 462

 Score =  349 bits (896), Expect = 8e-95
 Identities = 175/194 (90%), Positives = 184/194 (94%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GKLLLKVPPTLRFVMDGEMPDYL AKDLILQIIGEI+VAGATYKS
Sbjct: 165 ATGIGNTDAGFVLGTGKLLLKVPPTLRFVMDGEMPDYLQAKDLILQIIGEISVAGATYKS 224

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P DS T+KYLE KT++PYE VYSD QA
Sbjct: 225 MEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTFKYLEDKTTLPYEPVYSDAQA 284

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFD++KLEPLVAKPHSPDNRALAREC+DVKI+RVYIGSCTGGKTEDFMA AKVF
Sbjct: 285 RFLSEYRFDISKLEPLVAKPHSPDNRALARECRDVKIDRVYIGSCTGGKTEDFMAVAKVF 344

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 345 LAS-GKKVKVPTFL 357

[6][TOP]
>UniRef100_C5XT62 Putative uncharacterized protein Sb04g002120 n=1 Tax=Sorghum
           bicolor RepID=C5XT62_SORBI
          Length = 507

 Score =  342 bits (876), Expect = 2e-92
 Identities = 169/194 (87%), Positives = 182/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GK LLKVPPT+RFV+DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 210 ATGIGNTDAGFVLGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYKS 269

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMV+EAGGKNGV+P D  T+KYLEGKTSV YE VYSD QA
Sbjct: 270 MEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYLEGKTSVDYEPVYSDAQA 329

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVK++RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 330 RFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKVDRVYIGSCTGGKTEDFLAAAKVF 389

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 390 LAS-GKKVKVPTFL 402

[7][TOP]
>UniRef100_Q6Z702 Os02g0125100 protein n=2 Tax=Oryza sativa RepID=Q6Z702_ORYSJ
          Length = 514

 Score =  341 bits (874), Expect = 3e-92
 Identities = 168/194 (86%), Positives = 182/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFV+G GK LLKVPPT+RFV+DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 217 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYKS 276

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESLNMEERMTLCNMV+EAGGKNGV+P D  T+ YLEGKTSV YE VYSD QA
Sbjct: 277 MEFVGSTVESLNMEERMTLCNMVIEAGGKNGVVPADQTTFNYLEGKTSVEYEPVYSDAQA 336

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF+S+YRFDV+KLEP++AKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF AAAKVF
Sbjct: 337 RFVSDYRFDVSKLEPVIAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFFAAAKVF 396

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 397 LAS-GKKVKVPTFL 409

[8][TOP]
>UniRef100_UPI0001983576 PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI0001983576
          Length = 508

 Score =  339 bits (870), Expect = 8e-92
 Identities = 169/194 (87%), Positives = 183/194 (94%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDA FVLG GK+LLKVPPTLRFVMDGEMP+YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 211 ATGIGNTDAAFVLGTGKILLKVPPTLRFVMDGEMPNYLLAKDLILQIIGEISVSGATYKS 270

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG+TVESL MEERMTLCNMV+EAGGKNGV+P DS T+KYLE KTS+PYE VYSD+QA
Sbjct: 271 MEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYLEDKTSLPYEPVYSDEQA 330

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFD++KLEPLVAKPHSPD  ALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 331 RFLSEYRFDISKLEPLVAKPHSPDKCALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 390

Query: 543 LASGGKKVKVPTFL 584
            AS GKKVKVPTFL
Sbjct: 391 HAS-GKKVKVPTFL 403

[9][TOP]
>UniRef100_A7NXJ3 Chromosome chr5 scaffold_2, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7NXJ3_VITVI
          Length = 507

 Score =  339 bits (870), Expect = 8e-92
 Identities = 169/194 (87%), Positives = 183/194 (94%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDA FVLG GK+LLKVPPTLRFVMDGEMP+YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 228 ATGIGNTDAAFVLGTGKILLKVPPTLRFVMDGEMPNYLLAKDLILQIIGEISVSGATYKS 287

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG+TVESL MEERMTLCNMV+EAGGKNGV+P DS T+KYLE KTS+PYE VYSD+QA
Sbjct: 288 MEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYLEDKTSLPYEPVYSDEQA 347

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFD++KLEPLVAKPHSPD  ALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 348 RFLSEYRFDISKLEPLVAKPHSPDKCALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 407

Query: 543 LASGGKKVKVPTFL 584
            AS GKKVKVPTFL
Sbjct: 408 HAS-GKKVKVPTFL 420

[10][TOP]
>UniRef100_B4FG11 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B4FG11_MAIZE
          Length = 505

 Score =  339 bits (869), Expect = 1e-91
 Identities = 168/194 (86%), Positives = 181/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GK LLKVPPT+RF++DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 208 ATGIGNTDAGFVLGTGKALLKVPPTIRFILDGEMPPYLLAKDLILQIIGEISVSGATYKS 267

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMV+EAGGKNGV+P D  T+KYLEGKTSV YE VYSD QA
Sbjct: 268 MEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYLEGKTSVDYEPVYSDAQA 327

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF S+YRFDV+KLEP+VAKPHSPDNRA ARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 328 RFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 387

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 388 LAS-GKKVKVPTFL 400

[11][TOP]
>UniRef100_C4JBG7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4JBG7_MAIZE
          Length = 505

 Score =  338 bits (867), Expect = 2e-91
 Identities = 167/194 (86%), Positives = 182/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFV+G GK LLKVPPT+RFV+DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 208 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYKS 267

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P D  T+KYLEG+TSV Y+ VYSD +A
Sbjct: 268 MEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYLEGRTSVDYQPVYSDAEA 327

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 328 RFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 387

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 388 LAS-GKKVKVPTFL 400

[12][TOP]
>UniRef100_B6TYJ6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6TYJ6_MAIZE
          Length = 492

 Score =  338 bits (867), Expect = 2e-91
 Identities = 167/194 (86%), Positives = 182/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFV+G GK LLKVPPT+RFV+DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 208 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYKS 267

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P D  T+KYLEG+TSV Y+ VYSD +A
Sbjct: 268 MEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYLEGRTSVDYQPVYSDAEA 327

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF
Sbjct: 328 RFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVF 387

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 388 LAS-GKKVKVPTFL 400

[13][TOP]
>UniRef100_B6U6T6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6U6T6_MAIZE
          Length = 504

 Score =  338 bits (866), Expect = 2e-91
 Identities = 167/194 (86%), Positives = 181/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GK LLKVPPT+RF++DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 207 ATGIGNTDAGFVLGTGKALLKVPPTIRFILDGEMPPYLLAKDLILQIIGEISVSGATYKS 266

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMV+EAGGKNGV+P D  T+KYLEGKTSV YE VYSD QA
Sbjct: 267 MEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYLEGKTSVDYEPVYSDAQA 326

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF S+YRFDV+KLEP+VAKPHSPDNRA ARECKDVKI+RVYIGSCTGGKTEDF+AAAK+F
Sbjct: 327 RFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDVKIDRVYIGSCTGGKTEDFLAAAKLF 386

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 387 LAS-GKKVKVPTFL 399

[14][TOP]
>UniRef100_C4IZQ5 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4IZQ5_MAIZE
          Length = 505

 Score =  337 bits (863), Expect = 5e-91
 Identities = 166/194 (85%), Positives = 181/194 (93%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFV+G GK LLKVPPT+RFV+DGEMP YLLAKDLILQIIGEI+V+GATYKS
Sbjct: 208 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYKS 267

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P D  T+KYLEG+TSV Y+ VYSD +A
Sbjct: 268 MEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYLEGRTSVDYQPVYSDAEA 327

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF+AA KVF
Sbjct: 328 RFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFLAAVKVF 387

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 388 LAS-GKKVKVPTFL 400

[15][TOP]
>UniRef100_Q94AR8 3-isopropylmalate dehydratase n=1 Tax=Arabidopsis thaliana
           RepID=LEUC_ARATH
          Length = 509

 Score =  325 bits (832), Expect = 2e-87
 Identities = 158/194 (81%), Positives = 180/194 (92%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GK+LLKVPPT+RF++DGEMP YL AKDLILQIIGEI+VAGATYK+
Sbjct: 212 ATGIGNTDAGFVLGTGKILLKVPPTMRFILDGEMPSYLQAKDLILQIIGEISVAGATYKT 271

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G+T+ESL+MEERMTLCNMVVEAGGKNGVIPPD+ T  Y+E +TSVP+E VYSD  A
Sbjct: 272 MEFSGTTIESLSMEERMTLCNMVVEAGGKNGVIPPDATTLNYVENRTSVPFEPVYSDGNA 331

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            F+++YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDFMAAAK+F
Sbjct: 332 SFVADYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFMAAAKLF 391

Query: 543 LASGGKKVKVPTFL 584
            A+ G+KVKVPTFL
Sbjct: 392 HAA-GRKVKVPTFL 404

[16][TOP]
>UniRef100_A9TGU1 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9TGU1_PHYPA
          Length = 518

 Score =  314 bits (805), Expect = 3e-84
 Identities = 154/194 (79%), Positives = 175/194 (90%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGF++G GKLL+KVPPTLRFV+DGEMP YLLAKDLILQIIGEI+VAGATY++
Sbjct: 222 ATGIGNTDAGFIMGTGKLLIKVPPTLRFVLDGEMPKYLLAKDLILQIIGEISVAGATYRA 281

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG+ V+++ ME+RMTLCNMVVEAGGKNGV+P D+ T KYLEGKTS PY+   SD  A
Sbjct: 282 MEFVGTAVDAMTMEDRMTLCNMVVEAGGKNGVVPADATTAKYLEGKTSKPYQVFTSDGNA 341

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            FL EYRFDV+KLEPLVAKPHSPDNR LARECKDVKI+RVYIGSCTGGKTEDF+AAA++ 
Sbjct: 342 SFLQEYRFDVSKLEPLVAKPHSPDNRGLARECKDVKIDRVYIGSCTGGKTEDFLAAAEL- 400

Query: 543 LASGGKKVKVPTFL 584
           LA  G+KVKVPTFL
Sbjct: 401 LAISGQKVKVPTFL 414

[17][TOP]
>UniRef100_B8LQ24 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQ24_PICSI
          Length = 516

 Score =  314 bits (804), Expect = 4e-84
 Identities = 152/194 (78%), Positives = 177/194 (91%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A+GIGNTDAGF++G GKLL+KVP TLRFVMDGEMP +LLAKDLILQIIGEITV+GATY++
Sbjct: 220 ASGIGNTDAGFIMGTGKLLVKVPATLRFVMDGEMPHFLLAKDLILQIIGEITVSGATYRA 279

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GSTV+SL ME+RMTLCNMVVEAGGKNGV+  D +T+ YLEGKTS  +E++YSD+ A
Sbjct: 280 MEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVDADQITFDYLEGKTSSSFEALYSDEAA 339

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           R+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +KI+RVYIGSCTGGKTEDFMAAAK+ 
Sbjct: 340 RYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKTEDFMAAAKIM 399

Query: 543 LASGGKKVKVPTFL 584
           + S G+KVKVPTFL
Sbjct: 400 I-SAGQKVKVPTFL 412

[18][TOP]
>UniRef100_B8LQY6 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQY6_PICSI
          Length = 515

 Score =  312 bits (799), Expect = 1e-83
 Identities = 152/194 (78%), Positives = 175/194 (90%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A+GIGNTDAGF++G GKLL+KVP TLRFVMDGEMP +LLAKDLILQIIGEITV+G TY++
Sbjct: 219 ASGIGNTDAGFIMGTGKLLIKVPATLRFVMDGEMPHFLLAKDLILQIIGEITVSGGTYRA 278

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GSTV+SL ME+RMTLCNMVVEAGGKNGV+  D  T+ YLEGKTS  +E++YSD+ A
Sbjct: 279 MEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVAADQTTFDYLEGKTSSSFEALYSDEAA 338

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           R+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +KI+RVYIGSCTGGKTEDFMAAAK+ 
Sbjct: 339 RYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKTEDFMAAAKI- 397

Query: 543 LASGGKKVKVPTFL 584
           L S G+KVKVPTFL
Sbjct: 398 LISAGQKVKVPTFL 411

[19][TOP]
>UniRef100_A8JG03 Isopropylmalate dehydratase, large subunit n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8JG03_CHLRE
          Length = 487

 Score =  294 bits (753), Expect = 3e-78
 Identities = 138/194 (71%), Positives = 170/194 (87%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+GNTDAGF+LG GKLL+KVPPT+RF+MDGEMP+YLLAKDLILQIIGEI+VAGATYK+
Sbjct: 191 ATGVGNTDAGFILGTGKLLIKVPPTMRFIMDGEMPEYLLAKDLILQIIGEISVAGATYKA 250

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GS +E +NM+ERMT+CNMVVEAGGKNGVI PD  T+ Y++ +T   +E VYSD  A
Sbjct: 251 MEFAGSAIEGMNMDERMTICNMVVEAGGKNGVIAPDQTTFDYVKARTQEAFEPVYSDGAA 310

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++++Y++DV+KLEPLVA PHSPDNR  AREC DVKI+RVYIGSCTGGKTEDF++AAK+F
Sbjct: 311 SYIADYKWDVSKLEPLVAAPHSPDNRKTARECSDVKIDRVYIGSCTGGKTEDFISAAKLF 370

Query: 543 LASGGKKVKVPTFL 584
             +  ++VKVPT+L
Sbjct: 371 YRA-KRQVKVPTYL 383

[20][TOP]
>UniRef100_B9SQS6 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS6_RICCO
          Length = 621

 Score =  292 bits (747), Expect = 1e-77
 Identities = 153/194 (78%), Positives = 160/194 (82%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG TDAGFVLG GKLLLKVPPTLRFV+DGEMPDYLLAKDLILQ              
Sbjct: 350 ATGIGITDAGFVLGTGKLLLKVPPTLRFVIDGEMPDYLLAKDLILQ-------------- 395

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
                       MEERMTLCNMV+EAGGKNGVIP DS T+KYLE KTSVPYE VYSD+QA
Sbjct: 396 ------------MEERMTLCNMVIEAGGKNGVIPADSTTFKYLEDKTSVPYEPVYSDEQA 443

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           RFLSEYRFD++KLEPLVAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF AAAKVF
Sbjct: 444 RFLSEYRFDISKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFTAAAKVF 503

Query: 543 LASGGKKVKVPTFL 584
           LAS GKKVKVPTFL
Sbjct: 504 LAS-GKKVKVPTFL 516

[21][TOP]
>UniRef100_Q111B2 Homoaconitate hydratase family protein n=1 Tax=Trichodesmium
           erythraeum IMS101 RepID=Q111B2_TRIEI
          Length = 439

 Score =  279 bits (713), Expect = 1e-73
 Identities = 133/194 (68%), Positives = 163/194 (84%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDA F+ G GKLL+KVP T+RF+++GEMP+YLLAKDLILQIIG+I+V+GATY++
Sbjct: 148 ATGIGNTDAAFIAGTGKLLVKVPATMRFILNGEMPNYLLAKDLILQIIGDISVSGATYRT 207

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G TV  + MEERMTLCNMV+EAGGKNGVI PD +T++YL G+T  P+ES YSD+ A
Sbjct: 208 MEFAGETVGQMTMEERMTLCNMVIEAGGKNGVIAPDEMTFEYLRGRTDKPFESFYSDKNA 267

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            F S+  +DVTKLEP+VAKPHSPDN+ LAR C+DVKI+RVYIGSCTGGKT DF+ AAK+ 
Sbjct: 268 EFYSDRSYDVTKLEPVVAKPHSPDNKELARNCQDVKIDRVYIGSCTGGKTSDFLHAAKLI 327

Query: 543 LASGGKKVKVPTFL 584
                 +VKVPT+L
Sbjct: 328 ---KDHQVKVPTYL 338

[22][TOP]
>UniRef100_UPI00016C35D3 homoaconitate hydratase family protein n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C35D3
          Length = 435

 Score =  233 bits (595), Expect = 6e-60
 Identities = 118/196 (60%), Positives = 146/196 (74%), Gaps = 2/196 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GKL LKVPPT+RFV  G +P YL+AKDLIL +IG+I V GATY++
Sbjct: 142 ATGIGNTDAGFVLGTGKLWLKVPPTMRFVFHGNLPPYLMAKDLILAVIGDIGVDGATYRA 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKT--SVPYESVYSDQ 356
           MEF G  V +LN+EERMTLCNM +EAGGKNG+I  D VT  Y+  +   + PY  V SD 
Sbjct: 202 MEFDGDGVYALNIEERMTLCNMAIEAGGKNGIIAADQVTLDYVNKRNAGNRPYTVVKSDP 261

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A+F+ E  +DV+KLEP++AKPHSPDN+A   + K  K++R YIGSCTGGK  DF AAA+
Sbjct: 262 GAQFVFEKVYDVSKLEPVIAKPHSPDNKAFVSQVKGTKLDRAYIGSCTGGKLTDFKAAAQ 321

Query: 537 VFLASGGKKVKVPTFL 584
           +     GK VK+ TF+
Sbjct: 322 LL---NGKTVKIDTFV 334

[23][TOP]
>UniRef100_C1ZRL8 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Rhodothermus marinus
           DSM 4252 RepID=C1ZRL8_RHOMR
          Length = 432

 Score =  231 bits (588), Expect = 4e-59
 Identities = 108/194 (55%), Positives = 146/194 (75%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+GNTDA F++G GK+ +KVP T+RF+ +G +P YL+AKDLIL IIG+I + GATY++
Sbjct: 141 STGVGNTDAAFIMGTGKIWVKVPETMRFIFEGSLPPYLMAKDLILAIIGDIGIDGATYRA 200

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V  L++EERMTL NM +EAGGK+G+I PD  T  Y+  +T  P+E  +SD  A
Sbjct: 201 MEFDGEAVYDLSIEERMTLTNMAIEAGGKSGIIAPDEKTIAYVRERTDAPFEIYHSDPDA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           R+ SEY +DV+KLEP+VAKPH PDNRA   E    K++R YIGSCTGGK EDF+AAA++ 
Sbjct: 261 RYHSEYVYDVSKLEPVVAKPHRPDNRATVTEVAGTKLDRAYIGSCTGGKLEDFIAAARIL 320

Query: 543 LASGGKKVKVPTFL 584
               G++V++ TF+
Sbjct: 321 ---KGQEVRIDTFV 331

[24][TOP]
>UniRef100_C4C1N1 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Sebaldella termitidis
           ATCC 33386 RepID=C4C1N1_9FUSO
          Length = 435

 Score =  229 bits (585), Expect = 9e-59
 Identities = 104/194 (53%), Positives = 145/194 (74%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDA F+LG GKL +KVP T+RF  +G+ P+Y++ KD++L++IG+I   GATYK 
Sbjct: 141 ATGIGNTDAAFILGTGKLWVKVPETMRFTFEGKFPEYVMGKDVVLKVIGDIGFDGATYKC 200

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G  +   NMEERMT+CNM +EAGGK G+I PD +T +Y+  KT  P+E +YSD+ A
Sbjct: 201 MQFDGDAIHGFNMEERMTICNMAIEAGGKCGIIEPDEITVEYVTEKTDKPFELIYSDKDA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + +EY+++  ++EP+VAKP +P N  LA+   DVK++R YIGSCTGGKT DF+AAAK+ 
Sbjct: 261 DYSAEYKYNANEMEPIVAKPFNPGNTDLAKNLGDVKLDRAYIGSCTGGKTTDFVAAAKIL 320

Query: 543 LASGGKKVKVPTFL 584
               G+KV + TF+
Sbjct: 321 ---KGRKVAIETFI 331

[25][TOP]
>UniRef100_B3QSN7 Homoaconitate hydratase family protein n=1 Tax=Chloroherpeton
           thalassium ATCC 35110 RepID=B3QSN7_CHLT3
          Length = 431

 Score =  224 bits (570), Expect = 5e-57
 Identities = 106/194 (54%), Positives = 141/194 (72%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+GNTDA F+LG GK+  KVP +++FV DG+MP YL AKDLILQI+G+IT  GATY++
Sbjct: 141 STGVGNTDAAFILGTGKIWEKVPESMKFVFDGKMPKYLTAKDLILQILGDITTDGATYRA 200

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + SL ++ERMTL NM +EAGG +G+I  D +T  +++ +TS PYE  +SD  A
Sbjct: 201 MEFAGEAIHSLPIDERMTLTNMAIEAGGMSGIIAADEITEAFVKARTSAPYEIFHSDPDA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++ S Y ++V +LEP+VAKPHSPDNR   R     K+ + Y+GSCTGGK  DF  AAKV 
Sbjct: 261 KYFSTYHYNVEELEPVVAKPHSPDNRDTVRNVAGTKLTKCYLGSCTGGKLTDFEFAAKVL 320

Query: 543 LASGGKKVKVPTFL 584
               G+ VKVPTF+
Sbjct: 321 ---HGQTVKVPTFV 331

[26][TOP]
>UniRef100_B3EHN8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium limicola
           DSM 245 RepID=B3EHN8_CHLL2
          Length = 431

 Score =  223 bits (569), Expect = 7e-57
 Identities = 110/191 (57%), Positives = 140/191 (73%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP +++F+ +G+MP+YL AKDLILQI+G+I   GATY++M
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPESMKFIFEGDMPEYLCAKDLILQILGDIGTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  V SL ++ERMTLCNM +EAGG NG+I  D+VT  Y++  +S PYE   SD  A 
Sbjct: 202 EFDGEAVYSLPVDERMTLCNMAIEAGGMNGIIAADAVTEAYVKAHSSKPYEIFQSDPDAD 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S YR++  +LEP+VAKPHSPDNRA  R  +  KI + YIGSCTGGK  DFM AAK+  
Sbjct: 262 YHSVYRYNARELEPVVAKPHSPDNRATVRSMQGTKITKSYIGSCTGGKLTDFMLAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              GK+V VPT
Sbjct: 321 --KGKQVTVPT 329

[27][TOP]
>UniRef100_Q0YQD5 Homoaconitate hydratase family protein:3-isopropylmalate
           dehydratase, prokaryotic n=1 Tax=Chlorobium ferrooxidans
           DSM 13031 RepID=Q0YQD5_9CHLB
          Length = 431

 Score =  222 bits (565), Expect = 2e-56
 Identities = 111/191 (58%), Positives = 136/191 (71%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TGIGNTDA F+LG GKL  KVP +++F  DG MP+YL AKDLILQI+G+IT  GATYK+M
Sbjct: 142 TGIGNTDAAFILGTGKLWEKVPESIKFTFDGVMPEYLTAKDLILQILGDITTDGATYKAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  + SL MEERMTL NM +EAGG NG+I  DSV   Y+  ++  PYE   SD  A+
Sbjct: 202 EFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADSVAESYVRARSQKPYEIFRSDPDAK 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S Y ++V +LEP+VA+PHSPDNRA  R  +  KI + YIGSCTGGK  DF+ AAK+  
Sbjct: 262 YHSRYHYNVRELEPVVAQPHSPDNRATVRSVQGTKITKSYIGSCTGGKLTDFVMAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              GKKV V T
Sbjct: 321 --KGKKVSVTT 329

[28][TOP]
>UniRef100_Q3APC5 3-isopropylmalate dehydratase n=1 Tax=Chlorobium chlorochromatii
           CaD3 RepID=Q3APC5_CHLCH
          Length = 431

 Score =  221 bits (564), Expect = 2e-56
 Identities = 110/191 (57%), Positives = 137/191 (71%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TGIGNTDA F+LG GKL  KVP +++F  +GEMP YL AKDLILQI+G+IT  GATY++M
Sbjct: 142 TGIGNTDAAFILGTGKLWEKVPESMKFTFEGEMPAYLTAKDLILQILGDITTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  + SL MEERMTL NM +EAGG NG+I  D++  +Y++ +T  PYE   SD  A+
Sbjct: 202 EFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADNIAEEYVKARTKKPYEIFQSDPDAK 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S YR++V  LEP+VA+PHSPDNRA  R     KI + YIGSCTGGK  DFM AAK+  
Sbjct: 262 YHSTYRYNVRDLEPVVAQPHSPDNRATVRSVAGTKITKSYIGSCTGGKLSDFMMAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              G+KV V T
Sbjct: 321 --KGQKVTVTT 329

[29][TOP]
>UniRef100_B4SDL0 Homoaconitate hydratase family protein n=1 Tax=Pelodictyon
           phaeoclathratiforme BU-1 RepID=B4SDL0_PELPB
          Length = 431

 Score =  221 bits (564), Expect = 2e-56
 Identities = 111/191 (58%), Positives = 136/191 (71%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP ++ F  DG+MP+YL AKDLILQI+G+IT  GATY +M
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPESILFTFDGQMPEYLTAKDLILQILGDITTDGATYCAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  + SL MEERMTL NM +EAGG NG+I  DS+   Y++ ++  PYE   SD  AR
Sbjct: 202 EFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADSIAENYVKARSQKPYELFQSDPDAR 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S+YR+DV  LEP+VA+PHSPDNRA  R  +  KI + YIGSCTGGK  DFM AAK+  
Sbjct: 262 YHSKYRYDVRTLEPVVAQPHSPDNRATVRSVQGTKITKSYIGSCTGGKLTDFMMAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              G KV V T
Sbjct: 321 --KGHKVSVTT 329

[30][TOP]
>UniRef100_Q8KER8 3-isopropylmalate dehydratase, large subunit, putative n=1
           Tax=Chlorobaculum tepidum RepID=Q8KER8_CHLTE
          Length = 431

 Score =  221 bits (562), Expect = 4e-56
 Identities = 109/191 (57%), Positives = 138/191 (72%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP +++F  +G+MP+YL AKDLILQI+G+IT  GATY++M
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPDSMKFTFEGQMPEYLTAKDLILQILGDITTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  V SL ++ERMTLCNM +EAGG NG+I  D+VT  +++ +TS PYE   SD  A+
Sbjct: 202 EFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVTEAFVKARTSKPYEIFTSDPDAQ 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S YR++V K+EP+VAKPHSPDNRA         I + YIGSCTGGK  DF  AAK+  
Sbjct: 262 YHSMYRYNVEKMEPIVAKPHSPDNRATVHSVAGTPITKSYIGSCTGGKLTDFKLAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              GKKV V T
Sbjct: 321 --KGKKVAVTT 329

[31][TOP]
>UniRef100_A1BES2 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides DSM 266 RepID=A1BES2_CHLPD
          Length = 431

 Score =  220 bits (561), Expect = 6e-56
 Identities = 110/191 (57%), Positives = 135/191 (70%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP +++F  DG+MP+YL AKDLIL I+G+I   GATY++M
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPESMKFTFDGQMPEYLTAKDLILHILGDIGTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  V SL +EERMTL NM +EAGG NG+I  D++T  Y+  +T  PYE   SD  AR
Sbjct: 202 EFDGEAVFSLPIEERMTLTNMAIEAGGMNGIIAADAITEAYVNARTQKPYELFRSDPDAR 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S Y ++V +LEP+VA PHSPDNRA  R  +   I R YIGSCTGGK  DFM AAK+  
Sbjct: 262 YHSSYTYNVRELEPVVACPHSPDNRATVRSVQGTAITRSYIGSCTGGKLSDFMMAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              GKKV VPT
Sbjct: 321 --NGKKVSVPT 329

[32][TOP]
>UniRef100_B3QM97 Homoaconitate hydratase family protein n=1 Tax=Chlorobaculum parvum
           NCIB 8327 RepID=B3QM97_CHLP8
          Length = 431

 Score =  219 bits (558), Expect = 1e-55
 Identities = 109/191 (57%), Positives = 138/191 (72%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP +++F  +G+MP+YL AKDLILQI+G+I   GATY++M
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPDSMKFTFEGQMPEYLTAKDLILQILGDIGTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  V SL ++ERMTLCNM +EAGG NG+I  D+VT  +++ +TS PYE   SD  A+
Sbjct: 202 EFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVTEAFVKARTSKPYEIFQSDPDAQ 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S YR++V KLEP+VA+PHSPDNRA  R      I + YIGSCTGGK  DF  AAK+  
Sbjct: 262 YHSMYRYNVEKLEPVVAQPHSPDNRATVRSVAGTPITKSYIGSCTGGKITDFRLAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              GKKV V T
Sbjct: 321 --KGKKVAVTT 329

[33][TOP]
>UniRef100_A4SFC8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeovibrioides DSM 265 RepID=A4SFC8_PROVI
          Length = 431

 Score =  219 bits (558), Expect = 1e-55
 Identities = 108/191 (56%), Positives = 136/191 (71%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP ++ F  DGEMP+YL AKDLILQI+G+I   GATY++M
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPESMLFTFDGEMPEYLSAKDLILQILGDIGTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  + SL MEERMTL NM +E GG NG+I  D +T  +++ KTS PYE   SD  A 
Sbjct: 202 EFNGEAIHSLPMEERMTLTNMAIEGGGMNGIIAVDEITEAFVKSKTSKPYEIFTSDPGAA 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S+ R++ +++EP+VAKPHSPDNRA  +  K  KI + YIGSCTGGK  DF  AAK+  
Sbjct: 262 YFSKTRYNASEMEPVVAKPHSPDNRATVQSMKGTKITKSYIGSCTGGKLADFKLAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              GK+V VPT
Sbjct: 321 --SGKRVSVPT 329

[34][TOP]
>UniRef100_B4S6N0 Homoaconitate hydratase family protein n=1 Tax=Prosthecochloris
           aestuarii DSM 271 RepID=B4S6N0_PROA2
          Length = 432

 Score =  218 bits (556), Expect = 2e-55
 Identities = 109/191 (57%), Positives = 137/191 (71%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TGIGNTDA F+LG GKL  KVP +++FV DG MPDYL AKDLILQI+G+I   GATY++M
Sbjct: 142 TGIGNTDAAFILGTGKLWEKVPESMKFVFDGAMPDYLTAKDLILQILGDIGTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF GS V  L +EERMTL NM +EAGG NG+I  D VT  Y++ +TS PYE  +SD  A 
Sbjct: 202 EFDGSAVYQLPVEERMTLTNMAIEAGGMNGIIAADEVTEAYVKARTSKPYEIFHSDPDAI 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S Y ++V +LEP+VA+PHSPDNRA  R  +  +I + YIGSCTGGK  DF  AAK+  
Sbjct: 262 YHSIYHYNVEELEPVVAQPHSPDNRATVRSVQGTRITKSYIGSCTGGKLSDFKMAAKIL- 320

Query: 546 ASGGKKVKVPT 578
              G++V + T
Sbjct: 321 --NGQQVSIQT 329

[35][TOP]
>UniRef100_B3EKV4 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides BS1 RepID=B3EKV4_CHLPB
          Length = 432

 Score =  215 bits (548), Expect = 2e-54
 Identities = 108/191 (56%), Positives = 138/191 (72%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TGIGNTDA F+LG GK+  KVP +++F+ +GEMP+YL+AKDLILQI+G+I+  GATY++M
Sbjct: 142 TGIGNTDAAFILGTGKIWEKVPESMKFIFEGEMPEYLMAKDLILQILGDISTDGATYRAM 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF GS V SL MEERMTL NM +EAGG +G+I  DS+T  Y++ ++  PYE   SD  A 
Sbjct: 202 EFDGSAVFSLPMEERMTLTNMAIEAGGMSGIIAADSITEAYVKERSDKPYEIFTSDPDAL 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S +R+   +LEP+VA PHSPDNRA  R  +  KI + YIGSCTGGK  DF+ AAKV  
Sbjct: 262 YHSIHRYKTEELEPVVAMPHSPDNRATVRSVQGTKITKSYIGSCTGGKLIDFVMAAKVL- 320

Query: 546 ASGGKKVKVPT 578
              G  V VPT
Sbjct: 321 --KGNTVSVPT 329

[36][TOP]
>UniRef100_Q3B597 3-isopropylmalate dehydratase n=1 Tax=Chlorobium luteolum DSM 273
           RepID=Q3B597_PELLD
          Length = 431

 Score =  214 bits (545), Expect = 4e-54
 Identities = 105/191 (54%), Positives = 135/191 (70%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           +GIGNTDA F+LG GKL  KVP +++F  DG+MP YL AKDLILQI+G+I   GATY+++
Sbjct: 142 SGIGNTDAAFILGTGKLWEKVPESMKFTFDGQMPAYLTAKDLILQILGDIGTDGATYRAL 201

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  + SL MEERMTL NM +EAGG NG+I  D +T  +++ +T+  YE  +SD  A+
Sbjct: 202 EFDGDAIHSLPMEERMTLTNMAIEAGGMNGIIAVDEITEAFVKARTTKSYEIFHSDPDAK 261

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + S YR+D +KLEP+VAKPHSPDNRA  R      I + YIGSCTGGK  DF  AA++  
Sbjct: 262 YHSLYRYDASKLEPVVAKPHSPDNRATVRSVAGTPITKSYIGSCTGGKLTDFKMAARIL- 320

Query: 546 ASGGKKVKVPT 578
              G+KV V T
Sbjct: 321 --NGRKVAVTT 329

[37][TOP]
>UniRef100_C0PRG9 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=C0PRG9_PICSI
          Length = 237

 Score =  214 bits (544), Expect = 5e-54
 Identities = 104/134 (77%), Positives = 119/134 (88%)
 Frame = +3

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GSTV+SL ME+RMTLCNMVVEAGGKNGV+  D  T+ YLEGKTS  +E++YSD+ A
Sbjct: 1   MEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVAADQTTFDYLEGKTSSSFEALYSDEAA 60

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           R+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +KI+RVYIGSCTGGKTEDFMAAAK+ 
Sbjct: 61  RYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKTEDFMAAAKI- 119

Query: 543 LASGGKKVKVPTFL 584
           L S G+KVKVPTFL
Sbjct: 120 LISAGQKVKVPTFL 133

[38][TOP]
>UniRef100_B2VKF3 3-isopropylmalate dehydratase large subunit n=1 Tax=Erwinia
           tasmaniensis RepID=B2VKF3_ERWT9
          Length = 436

 Score =  199 bits (506), Expect = 1e-49
 Identities = 99/193 (51%), Positives = 135/193 (69%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G TDA + LG+G++ LKVP T+R    G MP YL AKDLIL ++  +TV GATY++
Sbjct: 141 AIGLGITDAAYALGSGEIPLKVPTTIRVNYHGVMPAYLQAKDLILGLLARLTVDGATYEA 200

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GS ++++++EERMT+CNMVVE G KNG++ P+  T  YL  +T +P+  V  D  A
Sbjct: 201 IEFGGSVIDAMSVEERMTICNMVVECGAKNGIMVPNQATLDYLATRTDIPFSVVEPDADA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           R+      +VT+++PLVAKPHSPDN       K+V I++ YIGSCTGGK  DF+AAA+V 
Sbjct: 261 RYSQVLDINVTEMQPLVAKPHSPDNVVAIDTLKNVAISQAYIGSCTGGKLADFIAAARVI 320

Query: 543 LASGGKKVKVPTF 581
               G+KV VPTF
Sbjct: 321 ---KGRKVVVPTF 330

[39][TOP]
>UniRef100_A6DRT0 3-isopropylmalate dehydratase n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DRT0_9BACT
          Length = 433

 Score =  198 bits (503), Expect = 3e-49
 Identities = 97/194 (50%), Positives = 133/194 (68%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDA F +G G+  LK+P T++FV++G++P  ++AKDLIL +IGEI  +GATY +
Sbjct: 141 ATGIGNTDAAFTMGTGRTWLKIPETIKFVLNGKLPKTMMAKDLILHMIGEIGFSGATYCA 200

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  ++ L++EERMT+CNM +EAGGKNGVI  D+    Y++ +T VPY    +D  A
Sbjct: 201 MEFEGPVIDELSIEERMTICNMAIEAGGKNGVIAADAKVEAYVKERTDVPYTLFKADADA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  + ++LEP VA P +PD R    E     + R YIGSCTGGKTEDF AAA++ 
Sbjct: 261 DYKDVYEINCSELEPTVAIPSAPDKRKGVSEIAGTDLTRAYIGSCTGGKTEDFAAAAEIM 320

Query: 543 LASGGKKVKVPTFL 584
               G+KV + TF+
Sbjct: 321 Y---GQKVAMDTFV 331

[40][TOP]
>UniRef100_B3E0P6 3-isopropylmalate dehydratase large subunit n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3E0P6_METI4
          Length = 455

 Score =  196 bits (497), Expect = 1e-48
 Identities = 102/198 (51%), Positives = 131/198 (66%), Gaps = 5/198 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFV+G GKLL+KVPPTL+F +DGE+   ++AKDLIL IIGEI   GATY +
Sbjct: 159 ATGIGNTDAGFVMGTGKLLIKVPPTLQFYLDGELQKGVMAKDLILHIIGEIGFDGATYMA 218

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDS-----VTYKYLEGKTSVPYESVY 347
           M+F G  V +L +E+RMT+ NM +EAG KNG+ P D      V  K L+  T   +E V 
Sbjct: 219 MQFEGPGVSTLEIEDRMTVANMAIEAGAKNGIFPADQKTIDFVRQKVLKNGTKKEFEVVD 278

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+   F + Y  D++ +EP VA PH+P NR  A+E   VKI+R Y+GSCTGGK  DF+A
Sbjct: 279 PDKDQHFFASYFIDLSLVEPTVAAPHNPGNRMKAKELGSVKIDRAYLGSCTGGKLSDFIA 338

Query: 528 AAKVFLASGGKKVKVPTF 581
            A +      + V V TF
Sbjct: 339 FASIL---KNRTVSVETF 353

[41][TOP]
>UniRef100_Q6B920 3-isopropylmalate dehydratase large subunit n=1 Tax=Gracilaria
           tenuistipitata var. liui RepID=Q6B920_GRATL
          Length = 439

 Score =  193 bits (491), Expect = 7e-48
 Identities = 89/194 (45%), Positives = 136/194 (70%), Gaps = 1/194 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+GNTDA F+LG G++LL+VP T++ +  G++   ++AKDLIL ++ ++T  GATY+S
Sbjct: 145 AIGVGNTDAAFILGTGEILLRVPDTIKVIFHGQLGSNIMAKDLILLLLKDLTTQGATYQS 204

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSV-PYESVYSDQQ 359
           +EF G T++++++E+RMTLCNMV+EAG KNG+I P++ T +Y+  ++ +  ++ +  DQ 
Sbjct: 205 IEFTGETIDNMSIEDRMTLCNMVIEAGAKNGIIIPNNSTIEYINARSDIKDFDIIVPDQS 264

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +     +DVT ++P +AKPHSPDN       +  KI+R YIGSCTGGK+ DF AAAK+
Sbjct: 265 AHYTKVLEYDVTNIQPQIAKPHSPDNVDSIDNVEGEKIDRAYIGSCTGGKSSDFYAAAKI 324

Query: 540 FLASGGKKVKVPTF 581
                  KV + TF
Sbjct: 325 L---KNHKVSIDTF 335

[42][TOP]
>UniRef100_B4D0Q5 Aconitate hydratase domain protein n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0Q5_9BACT
          Length = 456

 Score =  192 bits (489), Expect = 1e-47
 Identities = 99/198 (50%), Positives = 134/198 (67%), Gaps = 5/198 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGF+LG GKLL+KVP T+RF ++GE+P  ++AKD+IL +IG+I   GATY++
Sbjct: 159 ATGIGNTDAGFILGTGKLLVKVPETMRFFLEGELPAGVMAKDVILHVIGDIGFDGATYRA 218

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL-----EGKTSVPYESVY 347
           M++ G  V  ++M++RMT+ NM +EAGGKNG+ P D  T  Y+     E  T   +E   
Sbjct: 219 MQWEGPGVYGMSMDDRMTIANMAIEAGGKNGIFPFDEKTDAYVKDRVQENGTKSTFEPAE 278

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            DQ  +F+ +  FD++KLEP VA    P  R  A+E   V ++R YIGSCTGGKT DF+A
Sbjct: 279 IDQDQKFIYDKVFDLSKLEPTVACHPDPGQRKTAKELAGVSLDRAYIGSCTGGKTSDFLA 338

Query: 528 AAKVFLASGGKKVKVPTF 581
            A+V     GK VK+ TF
Sbjct: 339 FARVV---KGKSVKIDTF 353

[43][TOP]
>UniRef100_B3T8D2 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG5E24 RepID=B3T8D2_9ARCH
          Length = 423

 Score =  183 bits (465), Expect = 7e-45
 Identities = 89/192 (46%), Positives = 129/192 (67%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G+TD  +VL  G L  KVP TL F ++G++P++++AKDLIL+IIG+IT  G    +
Sbjct: 142 ACGLGHTDVAYVLLNGNLWFKVPETLYFKINGKLPEHVMAKDLILKIIGDITTEGGAGHA 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G+ +  +++E R+TL NM  EAG KNG+I PD   + YL  +    Y++VY D  A
Sbjct: 202 MQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLSERGVTEYDAVYDDDDA 261

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   Y +DVT+LEPLVAKP SP N ++ +E   +++++ YIGSCTG K ED  A AK+ 
Sbjct: 262 QYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIGSCTGAKYEDLEAVAKIL 321

Query: 543 LASGGKKVKVPT 578
               GKKVK+ T
Sbjct: 322 ---KGKKVKIRT 330

[44][TOP]
>UniRef100_B3TAM8 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8G2 RepID=B3TAM8_9ARCH
          Length = 423

 Score =  183 bits (464), Expect = 1e-44
 Identities = 89/192 (46%), Positives = 129/192 (67%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G+TD  +VL  G L  KVP TL F ++G++P++++AKDLIL+IIG+IT  G    +
Sbjct: 142 ACGLGHTDVAYVLLNGNLWFKVPETLYFKINGKLPEHVMAKDLILKIIGDITTEGGAGYA 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G+ +  +++E R+TL NM  EAG KNG+I PD   + YL  +    Y++VY D  A
Sbjct: 202 MQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLSERGVTEYDAVYDDDDA 261

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   Y +DVT+LEPLVAKP SP N ++ +E   +++++ YIGSCTG K ED  A AK+ 
Sbjct: 262 QYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIGSCTGAKYEDLEAVAKIL 321

Query: 543 LASGGKKVKVPT 578
               GKKVK+ T
Sbjct: 322 ---KGKKVKIRT 330

[45][TOP]
>UniRef100_B3T9D1 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG6J21 RepID=B3T9D1_9ARCH
          Length = 423

 Score =  183 bits (464), Expect = 1e-44
 Identities = 89/192 (46%), Positives = 129/192 (67%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G+TD  +VL  G L  KVP TL F ++G++P++++AKDLIL+IIG+IT  G    +
Sbjct: 142 ACGLGHTDVAYVLLNGNLWFKVPETLYFKINGKLPEHVMAKDLILKIIGDITTEGGAGYA 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G+ +  +++E R+TL NM  EAG KNG+I PD   + YL  +    Y++VY D  A
Sbjct: 202 MQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLSERGVTEYDAVYDDDDA 261

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   Y +DVT+LEPLVAKP SP N ++ +E   +++++ YIGSCTG K ED  A AK+ 
Sbjct: 262 QYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIGSCTGAKYEDLEAVAKIL 321

Query: 543 LASGGKKVKVPT 578
               GKKVK+ T
Sbjct: 322 ---KGKKVKIRT 330

[46][TOP]
>UniRef100_B9XBH0 Aconitate hydratase domain protein n=1 Tax=bacterium Ellin514
           RepID=B9XBH0_9BACT
          Length = 455

 Score =  182 bits (462), Expect = 2e-44
 Identities = 98/198 (49%), Positives = 133/198 (67%), Gaps = 5/198 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFV+G GKLLLKVP T+ F ++G +   ++AKD+IL  IGEI   GATY++
Sbjct: 159 ATGIGNTDAGFVMGTGKLLLKVPETMHFRLEGALQPGVMAKDIILHCIGEIGFDGATYRA 218

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-----TSVPYESVY 347
           M+F GS V SL+M++RMT+ NM +EAGGKNG+   D+ T  +++ +     T   Y+ V 
Sbjct: 219 MQFDGSGVASLSMDDRMTIANMAIEAGGKNGIFEFDAQTKAFVDYRCKLNGTKATYQPVE 278

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D   +F+ +   D++KLEP VA    P  R  A+E  DVK++R YIGSCTGGKT DF+ 
Sbjct: 279 RDANEKFVYDMVVDLSKLEPTVACHPDPGQRKKAKE-MDVKLDRAYIGSCTGGKTSDFLE 337

Query: 528 AAKVFLASGGKKVKVPTF 581
            A+V     GK+V + TF
Sbjct: 338 FARVL---KGKRVMIDTF 352

[47][TOP]
>UniRef100_B3TBB7 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8O8 RepID=B3TBB7_9ARCH
          Length = 423

 Score =  182 bits (462), Expect = 2e-44
 Identities = 89/192 (46%), Positives = 128/192 (66%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G+TD  +VL  G L  KVP TL F + G++P+Y +AKDLIL+IIG+IT  G    +
Sbjct: 142 ACGLGHTDVAYVLLNGNLWFKVPETLYFKISGKLPEYTMAKDLILKIIGDITTEGGAGCA 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G  +  +++E R+TL NM  EAG KNG+I PD   + YL  +    Y++VY D+ A
Sbjct: 202 MQFGGDGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYLAERGVTEYDAVYDDEDA 261

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   Y +DV++LEPLVAKP SP N ++ +E   ++I++ YIGSCTG K ED +A A++ 
Sbjct: 262 QYAKTYEYDVSELEPLVAKPFSPQNVSVVQETTGIEIDKSYIGSCTGAKYEDLVAVARIL 321

Query: 543 LASGGKKVKVPT 578
               G+KVKV T
Sbjct: 322 ---KGRKVKVRT 330

[48][TOP]
>UniRef100_A4J182 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum reducens MI-1 RepID=A4J182_DESRM
          Length = 418

 Score =  178 bits (451), Expect = 3e-43
 Identities = 87/188 (46%), Positives = 120/188 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVP +++FV +G++  Y+  KDLIL  IG+I V GA YK+
Sbjct: 134 ATGVGSTDLAAAMALGETWFKVPESIKFVFNGQLNKYVGGKDLILHTIGQIGVDGALYKA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +  L+M+ R T+CNM +EAGGKNG+I PD +T +Y+EG+T  PY    SD  A
Sbjct: 194 MEFCGEAISQLSMDGRFTMCNMAIEAGGKNGIIQPDEITRQYVEGRTKRPYTFYTSDPDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   Y FDV K+EP VA PH P+N     +   V I++  IGSCT G+ ED   AA++ 
Sbjct: 254 QYSKVYEFDVNKIEPQVAFPHLPENARPVSQAGHVDIDQAVIGSCTNGRMEDLRLAAEIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[49][TOP]
>UniRef100_C9RAX0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ammonifex
           degensii KC4 RepID=C9RAX0_9THEO
          Length = 421

 Score =  178 bits (451), Expect = 3e-43
 Identities = 91/188 (48%), Positives = 120/188 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   +VPP+L+FV  G++  ++  KDLIL  IG+I V GA Y +
Sbjct: 135 ATGVGSTDLAAAMALGETWFRVPPSLKFVYTGKLKPWVGGKDLILYTIGQIGVEGALYCA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +E L+M+ R T+CNM VEAG KNG+I PD  T  YLEG+   PY+   SD  A
Sbjct: 195 MEFTGPVIEELSMDGRFTMCNMAVEAGAKNGIIAPDEKTAAYLEGRARRPYKFFQSDPDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           R+ + Y FDV++LEP VA PHSP N     E   + I++V IGSCT G+ ED   AA+V 
Sbjct: 255 RYQAVYEFDVSRLEPQVALPHSPANTRPVTEVTHITIDQVVIGSCTNGRLEDLRVAAQVL 314

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 315 ---KGKKV 319

[50][TOP]
>UniRef100_B0TCR2 3-isopropylmalate dehydratase large subunit n=1 Tax=Heliobacterium
           modesticaldum Ice1 RepID=LEUC_HELMI
          Length = 420

 Score =  177 bits (449), Expect = 5e-43
 Identities = 88/188 (46%), Positives = 123/188 (65%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVP  ++F  +G++P+ +  KDLIL  IG+I V GA Y+S
Sbjct: 136 ATGVGSTDLAAGIALGEAWFKVPEAIKFEYEGKLPEDVTGKDLILHTIGDIGVDGALYQS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GS ++ L+M+ RMT+CNM +EAGGKNG+I PD  T  Y+E + + PY+   SD  A
Sbjct: 196 MEFTGSAIDDLSMDGRMTMCNMAIEAGGKNGIIAPDKKTIAYVEERATRPYKVYTSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++    ++DV KLEP+VA PH P+N     E   V+I++V IGSCT G+ ED   AAK+ 
Sbjct: 256 KYARVIKYDVEKLEPVVAFPHLPENTRPVSEAGHVEIDQVVIGSCTNGRIEDLRMAAKIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---QGKKV 320

[51][TOP]
>UniRef100_A5D4W1 3-isopropylmalate dehydratase large subunit n=1 Tax=Pelotomaculum
           thermopropionicum SI RepID=A5D4W1_PELTS
          Length = 420

 Score =  177 bits (448), Expect = 7e-43
 Identities = 88/188 (46%), Positives = 121/188 (64%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+  LKVP +++F  DGEM  ++  KD+IL  IG+I V GA YK+
Sbjct: 136 STGVGSTDLAAAMALGETWLKVPESIKFEYDGEMQPWVGGKDMILHTIGDIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  VE L+M+ R T+CNM VEAGGKNG+I PD  T  Y+EG+   PY    SD  A
Sbjct: 196 MEFTGPAVEKLSMDGRFTMCNMAVEAGGKNGIIAPDETTRVYVEGRCKRPYRFYRSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   YR+D  ++EP VA PH P+N     E  +++I++V IGSCT G+ ED   AA+V 
Sbjct: 256 KYEKIYRYDAAQIEPQVAFPHLPENSRPVSEAGNIEIDQVVIGSCTNGRMEDLREAARVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[52][TOP]
>UniRef100_B5YEF5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           thermophilum H-6-12 RepID=B5YEF5_DICT6
          Length = 424

 Score =  175 bits (443), Expect = 3e-42
 Identities = 80/180 (44%), Positives = 121/180 (67%), Gaps = 1/180 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  + +  G++ LKVP +++FV  G++P ++  KDLIL  IG I V GA YK+
Sbjct: 136 STGVGSTDLAYAMATGEIWLKVPESIKFVYYGKLPQWVTGKDLILYTIGNIGVDGARYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + +L M +R+T+CNM +EAG KNG+I PD +T  Y+  +    ++   SD+ A
Sbjct: 196 MEFTGEVIRNLPMSDRLTICNMAIEAGAKNGIIEPDEITLDYVRNRAKRDFKIYKSDEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           ++   Y +DV+ LEP+VA PH P N + ++   KD+ I++VYIGSCT G+ ED   AAK+
Sbjct: 256 QYKEVYEWDVSDLEPIVAFPHLPSNIKKISEISKDIYIDQVYIGSCTNGRIEDLRIAAKI 315

[53][TOP]
>UniRef100_C8SB74 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SB74_FERPL
          Length = 419

 Score =  174 bits (442), Expect = 3e-42
 Identities = 94/198 (47%), Positives = 129/198 (65%), Gaps = 7/198 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD G V   GKL  KVP T++F ++G++P  + +KD+IL+IIG +   GA YK+
Sbjct: 135 ATGIGSTDMGAVFALGKLWFKVPETIKFEINGKLPRRVYSKDVILKIIGTVGANGANYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYES---VYSD 353
            EFVGST+E + M ER+T+ NM +E GGK G+IPPD VT  YL+    V YE    +YSD
Sbjct: 195 CEFVGSTIEKMEMSERLTMTNMAIEMGGKTGIIPPDKVTEDYLK-SIGVDYEIPEWLYSD 253

Query: 354 QQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAA 533
           + A +  E   DV+ LEP VA PHS DN     E + VKI++V+IGSCT G+ ED   AA
Sbjct: 254 EDA-YWKEVSLDVSNLEPQVACPHSVDNVKPVSEVEGVKIDQVFIGSCTNGRYEDLKVAA 312

Query: 534 KVF----LASGGKKVKVP 575
           ++     +A G + + +P
Sbjct: 313 EILKGEKVAKGVRLIVIP 330

[54][TOP]
>UniRef100_B8E2X0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           turgidum DSM 6724 RepID=B8E2X0_DICTD
          Length = 424

 Score =  174 bits (440), Expect = 6e-42
 Identities = 80/180 (44%), Positives = 122/180 (67%), Gaps = 1/180 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  + +  G++ LKVP +++FV  G++  ++  KDLIL  IG+I V GA YK+
Sbjct: 136 STGVGSTDLAYAMATGEIWLKVPESIKFVYYGKLSQWVTGKDLILYTIGQIGVDGARYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + +L+M +R+T+CNM +EAG KNG+I PD +T +Y+  +    ++   SD+ A
Sbjct: 196 MEFTGEVIRNLSMSDRLTICNMAIEAGAKNGIIEPDEITLEYVRNRAKRNFKVYKSDEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y +DVT LEP+VA PH P N + ++   KD+ I++VYIGSCT G+ ED   AAK+
Sbjct: 256 HYKEIYEWDVTNLEPIVAFPHLPSNIKKISDIGKDIYIDQVYIGSCTNGRIEDLRLAAKI 315

[55][TOP]
>UniRef100_Q8PZT3 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina mazei RepID=LEUC1_METMA
          Length = 391

 Score =  174 bits (440), Expect = 6e-42
 Identities = 84/194 (43%), Positives = 119/194 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G TD   +   GKL  KVP + R  ++G +  ++ AKDL L +IG+  +AGATYK+
Sbjct: 111 ATGVGATDMAEIFATGKLWFKVPESFRMTVEGSLDKHVYAKDLTLYLIGKTGIAGATYKA 170

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  +  L++  RMTLCNM +E G K G++PPD  T+ +L+ +   PYE VYSD  A
Sbjct: 171 VEFYGQAISELSVAGRMTLCNMAIEMGAKTGIVPPDEKTFDFLKNRAVAPYEPVYSDPDA 230

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +L E+ +D   +EP VA PH  DN     E +   +++V+IG+CT G+ ED   AA V 
Sbjct: 231 SYLKEFVYDAGDIEPQVACPHQVDNVKPVGEVEGTHVDQVFIGTCTNGRLEDLEVAASVL 290

Query: 543 LASGGKKVKVPTFL 584
               GKKV V T +
Sbjct: 291 ---KGKKVTVRTII 301

[56][TOP]
>UniRef100_B5ICW8 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5ICW8_9EURY
          Length = 419

 Score =  173 bits (439), Expect = 8e-42
 Identities = 93/197 (47%), Positives = 123/197 (62%), Gaps = 3/197 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD       GK+ L+VP T RF ++G+ P  + +KDLIL IIG I   GATYKS
Sbjct: 132 ATGMGSTDVAIAFALGKVWLRVPETHRFYIEGKFPKGVYSKDLILHIIGTIGADGATYKS 191

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-TSVPYESVYSDQQ 359
           MEF G T++ ++ME R T+ NM +EAGGK G+I PD+ T KYLE       Y  + SD  
Sbjct: 192 MEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYLEEMGRGEKYREIKSDDD 251

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK--DVKINRVYIGSCTGGKTEDFMAAA 533
           A F  EY F+V +LEP V+ PH+ DN     E K  +++I++VYIG+CT G+ ED   AA
Sbjct: 252 AWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKMNIRIDQVYIGTCTNGRIEDLRVAA 311

Query: 534 KVFLASGGKKVKVPTFL 584
           K+     G KV   T L
Sbjct: 312 KIL---DGNKVNKKTRL 325

[57][TOP]
>UniRef100_B5IBC4 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IBC4_9EURY
          Length = 419

 Score =  172 bits (437), Expect = 1e-41
 Identities = 93/197 (47%), Positives = 122/197 (61%), Gaps = 3/197 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD       GK+ L+VP T RF ++G  P  + +KDLIL IIG I   GATYKS
Sbjct: 132 ATGMGSTDVAIAFALGKVWLRVPETHRFYIEGNFPKGVYSKDLILHIIGTIGADGATYKS 191

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-TSVPYESVYSDQQ 359
           MEF G T++ ++ME R T+ NM +EAGGK G+I PD+ T KYLE       Y  + SD  
Sbjct: 192 MEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYLEEMGRGDKYREIKSDDD 251

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK--DVKINRVYIGSCTGGKTEDFMAAA 533
           A F  EY F+V +LEP V+ PH+ DN     E K  +++I++VYIG+CT G+ ED   AA
Sbjct: 252 AWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKMNIRIDQVYIGTCTNGRIEDLRVAA 311

Query: 534 KVFLASGGKKVKVPTFL 584
           K+     G KV   T L
Sbjct: 312 KIL---DGNKVNKKTRL 325

[58][TOP]
>UniRef100_A9A5B7 3-isopropylmalate dehydratase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A5B7_NITMS
          Length = 422

 Score =  172 bits (435), Expect = 2e-41
 Identities = 83/192 (43%), Positives = 127/192 (66%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G+TD  +VL  G++  KVP T  F ++G++PD+++AKDLIL+IIG+I   G  Y++
Sbjct: 141 ACGLGHTDIAYVLLNGQIWFKVPETDYFKLNGKLPDHVMAKDLILKIIGDIGTDGGNYRT 200

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G+ ++ +++E R+TLCNM  EAG KNG+   D     YL  + +   +    D  A
Sbjct: 201 MQFGGTGIDEMSVESRLTLCNMTTEAGAKNGIAEADQKVVDYLSSRGATNAQVFKGDDDA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++ + Y ++ +++EPLVAKP SP+N A+ RE   V++++ YIGSCTG K ED  AAAK+ 
Sbjct: 261 QYANVYEYEASEMEPLVAKPFSPENIAVVREAPSVELDKSYIGSCTGAKYEDLEAAAKIL 320

Query: 543 LASGGKKVKVPT 578
               GK VK+ T
Sbjct: 321 ---KGKTVKIRT 329

[59][TOP]
>UniRef100_Q1HPC3 Putative 3-isopropylmalate dehydratase large subunit (Fragment) n=1
           Tax=Theobroma cacao RepID=Q1HPC3_THECC
          Length = 120

 Score =  171 bits (434), Expect = 3e-41
 Identities = 86/90 (95%), Positives = 88/90 (97%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIGNTDAGFVLG GKLLLKVPPTLRFVMDGEMP YLLAKDLILQIIGEI+VAGATYKS
Sbjct: 31  ATGIGNTDAGFVLGTGKLLLKVPPTLRFVMDGEMPHYLLAKDLILQIIGEISVAGATYKS 90

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKN 272
           MEFVG+TVESLNMEERMTLCNMVVEAGGKN
Sbjct: 91  MEFVGTTVESLNMEERMTLCNMVVEAGGKN 120

[60][TOP]
>UniRef100_B1I1Y2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Candidatus
           Desulforudis audaxviator MP104C RepID=B1I1Y2_DESAP
          Length = 420

 Score =  171 bits (433), Expect = 4e-41
 Identities = 83/179 (46%), Positives = 119/179 (66%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVP +++FV +GE+P+++  KDLIL  IG+I V GA Y++
Sbjct: 136 ATGVGSTDLAAAMALGETWFKVPESVKFVYEGELPEWVGGKDLILYTIGDIGVEGALYQA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + +L+M+ R T+ NM +EAG KNG+I PD  T +Y++G+T  P+E   SD  A
Sbjct: 196 MEFTGPAIANLSMDGRFTMANMAIEAGAKNGIIAPDIRTLEYVQGRTIRPFELFASDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +     +DV+K+EP VA PHSPDN     E   V+I++V IGSCT G+ ED   AA+V
Sbjct: 256 VYARTITYDVSKIEPQVAFPHSPDNTRPVTEAGRVEIDQVVIGSCTNGRMEDLRLAARV 314

[61][TOP]
>UniRef100_C8W661 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=C8W661_9FIRM
          Length = 420

 Score =  171 bits (433), Expect = 4e-41
 Identities = 86/188 (45%), Positives = 121/188 (64%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+  LKVP ++ FV +GE+  ++  KDLIL IIG+I V GA YK+
Sbjct: 136 STGVGSTDLAAAMALGETWLKVPESMLFVFEGELRPWVGGKDLILHIIGDIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +E L+M+ R+T+ NM +EAGGKNG++ PD +T  Y+EG+   PY    SD  A
Sbjct: 196 MEFAGPAIEKLSMDGRLTMANMAIEAGGKNGIVAPDEITRAYVEGRVKKPYTFYKSDADA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +    R+D +K+EPLVA PH P+N     +   V++++V IGSCT G+ ED   AA V 
Sbjct: 256 VYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGLVELDQVVIGSCTNGRMEDLRLAAGVL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[62][TOP]
>UniRef100_O67078 3-isopropylmalate dehydratase large subunit n=1 Tax=Aquifex
           aeolicus RepID=LEUC_AQUAE
          Length = 432

 Score =  171 bits (432), Expect = 5e-41
 Identities = 82/190 (43%), Positives = 127/190 (66%), Gaps = 2/190 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  + +  G++ L+VP +++F+  G++  +++ KDLIL  IG+I V GA Y++
Sbjct: 135 ATGVGSTDIAYAMATGEVWLRVPESMKFIFYGKLKPWVMGKDLILYTIGQIGVDGALYRA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G T+ +L+ME+R T+ NM +EAGGK+G+I PD  T +Y++ +   P++   SD  A
Sbjct: 195 MEFDGETIRNLSMEQRFTIANMAIEAGGKSGIISPDEKTIEYVKQRAKRPWKVYQSDPDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + S Y +D +++EPLVA P+ P N     E   + I++ +IGSCT G+ ED   AAKVF
Sbjct: 255 EYHSVYEWDASQIEPLVAWPYLPSNVHPVSESTHITIDQAFIGSCTNGRIEDLRVAAKVF 314

Query: 543 LAS--GGKKV 566
            A+   GKKV
Sbjct: 315 EAALKQGKKV 324

[63][TOP]
>UniRef100_B8CX22 3-isopropylmalate dehydratase large subunit n=1 Tax=Halothermothrix
           orenii H 168 RepID=LEUC_HALOH
          Length = 420

 Score =  170 bits (430), Expect = 9e-41
 Identities = 83/179 (46%), Positives = 114/179 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G    KVP T++FV +GE+  ++  KDLIL  IG+I V GA Y++
Sbjct: 136 ATGVGSTDMAAAMATGYTWFKVPSTIQFVYNGELKPWVSGKDLILYTIGDIGVDGALYRA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G T+E+L+M+ RMT+ NM +EAGGK G+I PD  T+KYLE +    Y   YSD  A
Sbjct: 196 MEFTGETIENLSMDNRMTISNMAIEAGGKCGLIAPDEKTFKYLENRAQRDYTPCYSDDDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +     +DV+ +EP VA PH P+N     E  D+KI++  IGSCT G+ ED   AA +
Sbjct: 256 EYEKVIEYDVSDIEPQVAFPHLPENTRPISEEGDIKIDQAVIGSCTNGRMEDLRIAAGI 314

[64][TOP]
>UniRef100_B8GJ01 Homoaconitate hydratase family protein n=1 Tax=Methanosphaerula
           palustris E1-9c RepID=B8GJ01_METPE
          Length = 419

 Score =  167 bits (424), Expect = 4e-40
 Identities = 86/179 (48%), Positives = 113/179 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD GFVL  G L  +VP T+R  +DG     +  KDLIL IIG+I   GATYK+
Sbjct: 136 ATGIGSTDMGFVLKFGALYFRVPETIRMTIDGAFQRRVGPKDLILSIIGDIGADGATYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GST+  + M  RMTL NM +E GGK G++PPD VT+ YL+ +  V    + SD+ A
Sbjct: 196 VEFAGSTIRGMEMPGRMTLSNMAIEMGGKAGIVPPDQVTWDYLKSRRQVTPFELDSDEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            F  + R+DVT L P VA PH+ D+     E     +++V+IGSCT G+ ED   AA V
Sbjct: 256 TFADQRRYDVTNLVPKVAVPHNVDHVVDVTEVAGTHLDQVFIGSCTNGRFEDLAEAAAV 314

[65][TOP]
>UniRef100_Q8TLF1 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina acetivorans RepID=LEUC1_METAC
          Length = 424

 Score =  167 bits (422), Expect = 7e-40
 Identities = 81/194 (41%), Positives = 118/194 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G TD   +   GKL  KVP + R  ++G +   + AKDL L +IG+  +AGATYK+
Sbjct: 144 ATGVGATDMAEIFATGKLWFKVPESFRMTVEGSLRKGVYAKDLTLYLIGKTGIAGATYKA 203

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  +  L +  RMTLCNM +E G K G++PPD  T+++L+ + +  YE VY+D  A
Sbjct: 204 VEFYGQAIRELTVAGRMTLCNMAIEMGAKTGIVPPDEKTFEFLKNRAAATYEPVYADPDA 263

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +L E+ +D   +EP VA PH  DN     E +   +++V+IG+CT G+ ED   AA V 
Sbjct: 264 VYLEEFTYDADDIEPQVACPHQVDNVKPVGEVEGTHVDQVFIGTCTNGRLEDLEVAAAVL 323

Query: 543 LASGGKKVKVPTFL 584
               GK+V V T +
Sbjct: 324 ---KGKQVAVRTIV 334

[66][TOP]
>UniRef100_C8WM14 3-isopropylmalate dehydratase, large subunit n=2 Tax=Eggerthella
           lenta DSM 2243 RepID=C8WM14_9ACTN
          Length = 422

 Score =  166 bits (421), Expect = 9e-40
 Identities = 83/179 (46%), Positives = 112/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TDAG     GK   KVP +L F ++GE+   +  KD+IL IIG I V GA Y++
Sbjct: 138 ATGVGSTDAGVGYATGKAWFKVPESLLFKIEGELAPGVTGKDVILHIIGMIGVDGALYQA 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GS + +++M+ERM++ NM +EAGGK G+I  D VT  YL+G+T  PY   +SD  A
Sbjct: 198 MEFTGSAIRAMDMDERMSISNMAIEAGGKAGLIEVDDVTRAYLDGRTERPYTEYHSDADA 257

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y  D   + P V+ PH P N   A E +DVKI++  IGSCT G+  D   AA V
Sbjct: 258 TYAKVYEIDAASIVPTVSFPHLPSNTRPAAEARDVKIDQAVIGSCTNGRIADMRQAADV 316

[67][TOP]
>UniRef100_C4FRW1 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC
           17748 RepID=C4FRW1_9FIRM
          Length = 419

 Score =  166 bits (421), Expect = 9e-40
 Identities = 83/189 (43%), Positives = 124/189 (65%), Gaps = 1/189 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TDAG  +  GK   KVP T++  + G+   ++  KD+IL +IG+I V GA Y +
Sbjct: 135 STGVGSTDAGVAMAEGKTWFKVPETIKVELIGKPNKWVTGKDVILDLIGQIGVDGARYMA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V+ + M +R+T+CNM +EAGGK GV P D+VT +Y++G+ + P E +  D  A
Sbjct: 195 LEFAGDGVQHMTMADRLTICNMAIEAGGKCGVFPYDAVTEEYIKGRVNRPVEPIAPDADA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +      D++KL+P+VA PH P N     E  KD+KI++V IGSCT G+ ED +AAA++
Sbjct: 255 VYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKDIKIDQVIIGSCTNGRYEDLVAAAEI 314

Query: 540 FLASGGKKV 566
           F    G+KV
Sbjct: 315 F---KGRKV 320

[68][TOP]
>UniRef100_UPI00019E5A8A 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=UPI00019E5A8A
          Length = 310

 Score =  166 bits (420), Expect = 1e-39
 Identities = 84/185 (45%), Positives = 118/185 (63%)
 Frame = +3

Query: 12  IGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSMEF 191
           +G+TD    +  G+  LKVP ++ FV +GE+  ++  KDLIL IIG+I V GA YK+MEF
Sbjct: 29  LGSTDLAAAMALGETWLKVPESMLFVFEGELRPWVGGKDLILHIIGDIGVDGALYKAMEF 88

Query: 192 VGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQARFL 371
            G  +E L+M+ R+T+ NM +EAGGKNG++ PD +T  Y+EG+   PY    SD  A + 
Sbjct: 89  AGPAIEKLSMDGRLTMANMAIEAGGKNGIVAPDEITRAYVEGRVKKPYTFYKSDADAVYS 148

Query: 372 SEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLAS 551
              R+D +K+EPLVA PH P+N     +   V++++V IGSCT G+ ED   AA V    
Sbjct: 149 DIRRYDASKIEPLVAFPHLPENTRPVSQAGLVELDQVVIGSCTNGRMEDLRLAAGVL--- 205

Query: 552 GGKKV 566
            GKKV
Sbjct: 206 KGKKV 210

[69][TOP]
>UniRef100_C0V4R3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Veillonella
           parvula DSM 2008 RepID=C0V4R3_9FIRM
          Length = 419

 Score =  166 bits (420), Expect = 1e-39
 Identities = 82/189 (43%), Positives = 124/189 (65%), Gaps = 1/189 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TDAG  +  GK   KVP T++  + G+   ++  KD+IL +IG+I V GA Y +
Sbjct: 135 STGVGSTDAGVAMAEGKTWFKVPETIKVELIGKPNKWVTGKDVILDLIGQIGVDGARYMA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V+ + M +R+T+CNM +EAGGK GV P D++T +Y++G+ + P E +  D  A
Sbjct: 195 LEFAGEGVQHMTMADRLTICNMAIEAGGKCGVFPYDAITEEYIKGRVNRPVEPIAPDADA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +      D++KL+P+VA PH P N     E  KD+KI++V IGSCT G+ ED +AAA++
Sbjct: 255 VYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKDIKIDQVIIGSCTNGRYEDLVAAAEI 314

Query: 540 FLASGGKKV 566
           F    G+KV
Sbjct: 315 F---KGRKV 320

[70][TOP]
>UniRef100_Q46B45 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosarcina
           barkeri str. Fusaro RepID=Q46B45_METBF
          Length = 413

 Score =  166 bits (420), Expect = 1e-39
 Identities = 81/194 (41%), Positives = 118/194 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G TD   +   GKL  KVP + RF ++G +   + AKDL L +IG+  + GATYK+
Sbjct: 133 ATGVGATDMAEIFATGKLWFKVPESFRFTVEGRLGKGVYAKDLTLYLIGKTGIDGATYKA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  +  L++  RMTLCNM +E G K G++PPD  T+ +L+ + + PY+ VY+DQ A
Sbjct: 193 VEFYGQAISELSVSGRMTLCNMAIEMGAKTGIVPPDEKTFAFLKNRAAAPYDPVYADQDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++ E  +    +EP VA PH  DN     E +   I++V+IG+CT G+ ED   AA + 
Sbjct: 253 VYVKEPVYSAEDIEPQVACPHQVDNVKPVGEVEGTHIDQVFIGTCTNGRLEDLEVAAAIL 312

Query: 543 LASGGKKVKVPTFL 584
               GKKV V T +
Sbjct: 313 ---KGKKVAVRTIV 323

[71][TOP]
>UniRef100_A6TTR7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Alkaliphilus
           metalliredigens QYMF RepID=A6TTR7_ALKMQ
          Length = 420

 Score =  165 bits (417), Expect = 3e-39
 Identities = 82/179 (45%), Positives = 114/179 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  L+F++ G+  +++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMAMGKCWFKVPGALKFILKGKPQEWVSGKDIILHIIGTIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L M++R T+ NM +EAGGKNG+ P D +T +Y+   +  PY    +D+ A
Sbjct: 196 MEFVGEGIKHLTMDDRFTMANMAIEAGGKNGIFPVDELTLEYVRVHSKRPYTVYRADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y  D+++L P VA PH PDN     E  DVKI++V IGSCT G+ +D   AAKV
Sbjct: 256 VYEETYEIDLSRLLPTVAFPHIPDNIRTIDEVGDVKIDQVVIGSCTNGRIQDLRMAAKV 314

[72][TOP]
>UniRef100_A8UWH6 3-isopropylmalate dehydratase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1
           RepID=A8UWH6_9AQUI
          Length = 432

 Score =  164 bits (416), Expect = 4e-39
 Identities = 79/190 (41%), Positives = 124/190 (65%), Gaps = 2/190 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  + +  G++ L+VP +++F+  G+   +++ KDLIL  IGEI V GA Y++
Sbjct: 135 ATGVGSTDIAYAMATGEIWLRVPESMKFIFYGKPGAFVMGKDLILHTIGEIGVDGALYRA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +  L++E+R+T+ NM +EAGGK+G+I PD  T +Y++ +    ++   SD  A
Sbjct: 195 MEFEGEAIRELSVEQRLTITNMAIEAGGKSGIIAPDDKTIEYVKERAQKEWKVYESDPDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + S Y +D +K+EPLVA P+ P N     E   + +++ +IGSCT G+ ED   AAKVF
Sbjct: 255 EYHSVYEWDASKIEPLVAWPYLPSNVHPVSESTHINVDQAFIGSCTNGRIEDLRIAAKVF 314

Query: 543 LAS--GGKKV 566
            ++   GKKV
Sbjct: 315 ESALKQGKKV 324

[73][TOP]
>UniRef100_Q2FSZ6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanospirillum hungatei JF-1 RepID=Q2FSZ6_METHJ
          Length = 417

 Score =  164 bits (416), Expect = 4e-39
 Identities = 86/179 (48%), Positives = 115/179 (64%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD GF L  G L  +VP ++R  + G   + + AKDLIL II +ITV GATYK+
Sbjct: 133 ATGVGSTDMGFALRYGCLYFRVPESIRAHVTGRFQERVGAKDLILNIIKDITVDGATYKT 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G T+ESLNM  RMT CNM +E GGK G++PPD VT +YL G+ +   E++ SD  A
Sbjct: 193 VEFTGDTIESLNMAGRMTCCNMAIEMGGKAGIVPPDQVTKEYLSGRGTWREENLASDPDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            + S   +DV+ L P VA PH+ D      E     +++V+IGSCT G+ ED   AA V
Sbjct: 253 VYASWRDYDVSDLVPQVAVPHNVDQVVDVTEIAGTHVDQVFIGSCTNGRFEDLKEAALV 311

[74][TOP]
>UniRef100_UPI0001966B48 hypothetical protein SUBVAR_01587 n=1 Tax=Subdoligranulum variabile
           DSM 15176 RepID=UPI0001966B48
          Length = 419

 Score =  164 bits (415), Expect = 5e-39
 Identities = 80/195 (41%), Positives = 122/195 (62%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G    KVP  ++ V++G +   +  KD+IL +IGEI V+GA YKS
Sbjct: 136 STGVGSTDMAAGMAKGVAWFKVPAAIKVVLNGSLHRPVTGKDVILHLIGEIGVSGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V+SL ME+R+ +CNM +EAG KNG+ P D +   YL+G++  P+    +D  A
Sbjct: 196 LEFTGDGVKSLTMEDRLCICNMAIEAGAKNGIFPVDEICEAYLKGRSQRPWVKYEADPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D+  LEP V+ PH P+N  LA+E KD+KI+++ IGSCT G+ ED  AA ++ 
Sbjct: 256 EYERTVIIDLDTLEPTVSYPHLPENTHLAKEGKDIKIDQIVIGSCTNGRIEDMQAAYEIL 315

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 316 KGKHIAKGVRGIIIP 330

[75][TOP]
>UniRef100_C7GFH7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Roseburia
           intestinalis L1-82 RepID=C7GFH7_9FIRM
          Length = 420

 Score =  164 bits (415), Expect = 5e-39
 Identities = 81/188 (43%), Positives = 117/188 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++FV+ G+   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGKAWFKVPAAIKFVLTGKPAKWISGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +  L+M++R T+ NM +EAGGKNG+ P D++  +Y+E  +  PY    +D+ A
Sbjct: 196 MEFVGDGISFLSMDDRFTIANMAIEAGGKNGIFPVDNLAKEYMEAHSKRPYVVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  D++ L+P VA PH P+N     E  D+KI++V IGSCT G+ +D   AA + 
Sbjct: 256 EYEETYTIDLSTLKPTVAFPHLPENTKTIDEVGDIKIDQVVIGSCTNGRMDDLRVAASIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[76][TOP]
>UniRef100_A0RXN9 3-isopropylmalate dehydratase large subunit n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RXN9_CENSY
          Length = 429

 Score =  164 bits (415), Expect = 5e-39
 Identities = 78/192 (40%), Positives = 125/192 (65%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A G+G+TD  +VL  GK+  KVP T+   ++G +P +++AKD IL+IIG++   G  Y++
Sbjct: 147 ACGLGHTDMAYVLLYGKIWFKVPETVLLRLNGALPPHVMAKDYILRIIGDMGTDGGAYRT 206

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           M+F G+ +  +++E R+TL NM  EAG KNG+I  D  T  YL  + +   + V  D  A
Sbjct: 207 MQFAGTGITEMSVEGRLTLANMTTEAGAKNGIIEADKKTAGYLSSRGATGIKPVIGDDDA 266

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   + ++ +++EPLVAKP+SP+N ++ RE   V++++ YIGSCTG K ED  AAA++ 
Sbjct: 267 EYSEVFEYEGSEMEPLVAKPYSPENVSIVREAPSVELDKAYIGSCTGAKMEDLEAAARIL 326

Query: 543 LASGGKKVKVPT 578
               G+KV++ T
Sbjct: 327 ---KGRKVRIRT 335

[77][TOP]
>UniRef100_P81291 Isopropylmalate/citramalate isomerase large subunit n=1
           Tax=Methanocaldococcus jannaschii RepID=LEUC_METJA
          Length = 424

 Score =  164 bits (415), Expect = 5e-39
 Identities = 83/190 (43%), Positives = 116/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   GKL  KVP T+ F + G++  Y+ +KD+IL IIGE+ V GATYK+
Sbjct: 135 ATGIGSTDMAHVFATGKLWFKVPETIYFNITGDLQPYVTSKDVILSIIGEVGVDGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-----TSVPYESVY 347
            +F G TV+ +++  RMT+ NM +E GGK G+I PD  T +Y++       T  P+E + 
Sbjct: 195 CQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKEAMKKHGTERPFEVIK 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F   Y  +  K+EP+ A PH+ DN   ARE     I++V+IGSCT G+ ED   
Sbjct: 255 GDEDAEFAEVYEIEADKIEPVFACPHNVDNVKQAREVAGKPIDQVFIGSCTNGRLEDLRM 314

Query: 528 AAKVFLASGG 557
           A K+    GG
Sbjct: 315 AIKIIEKHGG 324

[78][TOP]
>UniRef100_Q8U2A1 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           furiosus RepID=LEUC1_PYRFU
          Length = 424

 Score =  164 bits (414), Expect = 6e-39
 Identities = 79/181 (43%), Positives = 121/181 (66%), Gaps = 2/181 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   +VP T++FV +G++  ++ +KDLIL  IG+I V GA YK 
Sbjct: 137 ATGVGSTDLAVAMATGEAWFRVPETIKFVYEGDLQPWVTSKDLILYTIGDIGVNGALYKV 196

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +E L++E+RMT+ NM +EAG K G+I PD  T +Y++G+    Y+   SD+ A
Sbjct: 197 MEFSGEVIEKLSVEQRMTMTNMAIEAGAKTGIIEPDKKTIEYVKGRAKREYKIYKSDEDA 256

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRA-LARECK-DVKINRVYIGSCTGGKTEDFMAAAK 536
           ++     +DV+K+EP VA PH P+N   +++  K ++KI++V IGSCT G+ ED   AA+
Sbjct: 257 KYYKVIEYDVSKIEPQVAFPHLPENTVPISKAAKMNIKIDQVVIGSCTNGRLEDLRMAAE 316

Query: 537 V 539
           V
Sbjct: 317 V 317

[79][TOP]
>UniRef100_C9RGT8 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           vulcanius M7 RepID=C9RGT8_9EURY
          Length = 422

 Score =  163 bits (413), Expect = 8e-39
 Identities = 84/190 (44%), Positives = 117/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   G+L  KVP TL F + GE+  Y+ +KD+IL IIGE+ V GATYK+
Sbjct: 133 ATGIGSTDMAHVFATGELWFKVPETLYFNISGELKPYVTSKDVILSIIGEVGVDGATYKA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-----TSVPYESVY 347
            +F G TV+++++  RMT+ NM +E GGK G+I PD  T +Y++       T  P+E + 
Sbjct: 193 CQFGGETVKNMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKEAMKKHGTERPFEIIK 252

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F   Y  +  K+EP+ A PH+ DN   ARE     I++V+IGSCT G+ ED   
Sbjct: 253 GDEDAEFEEVYEIEADKIEPVFACPHNVDNVKQAREVAGRPIDQVFIGSCTNGRVEDLRM 312

Query: 528 AAKVFLASGG 557
           A +V    GG
Sbjct: 313 AIEVIEKHGG 322

[80][TOP]
>UniRef100_C0FYL9 Putative uncharacterized protein n=1 Tax=Roseburia inulinivorans
           DSM 16841 RepID=C0FYL9_9FIRM
          Length = 436

 Score =  163 bits (412), Expect = 1e-38
 Identities = 83/189 (43%), Positives = 117/189 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F + G+   ++  KD+IL IIG I V GA YKS
Sbjct: 152 STGVGSTDMAAGMATGKAWFKVPSAMKFNLTGKPAAWISGKDIILHIIGMIGVDGALYKS 211

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +  L M++R T+ NM +EAGGKNG+ P D +  +Y+E  +  PY    +D+ A
Sbjct: 212 MEFVGDGIRYLTMDDRFTIANMAIEAGGKNGIFPVDDLAKQYMEEHSKRPYVVYEADEDA 271

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + +EY  D++ L+P V+ PH P+N     E  DVKI++V IGSCT G+ +D   AA V 
Sbjct: 272 EYDAEYTIDLSTLKPTVSFPHLPENTRTIDEVGDVKIDQVVIGSCTNGRMDDLRIAASVL 331

Query: 543 LASGGKKVK 569
               GKKVK
Sbjct: 332 ---KGKKVK 337

[81][TOP]
>UniRef100_Q12TV2 Homoaconitase large subunit n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=Q12TV2_METBU
          Length = 413

 Score =  163 bits (412), Expect = 1e-38
 Identities = 78/193 (40%), Positives = 120/193 (62%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD   +  +G+L  +VP T++    G++   +LAKD+ L++IG +  +GATYK+ 
Sbjct: 134 TGVGATDMSEIFASGELWFRVPETIKVTASGKLKKDVLAKDVTLKVIGTVGASGATYKAA 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G T+  L++  RMTL NM +E G K G++PPD  T+ +LEG+    YE VY+D+ A 
Sbjct: 194 EFYGDTITDLSISGRMTLSNMAIEMGAKAGIVPPDQKTFDFLEGRAVEGYEPVYADEDAE 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + +EY  D   LEP +A PH  DN     E +  K+++V+IG+CT G+ ED   AA++  
Sbjct: 254 YCAEYDIDGANLEPQIALPHQVDNVCDVSEIEGKKVDQVFIGTCTNGRLEDLEVAAEIL- 312

Query: 546 ASGGKKVKVPTFL 584
              G++V V T +
Sbjct: 313 --KGEQVAVRTIV 323

[82][TOP]
>UniRef100_B4U7U5 3-isopropylmalate dehydratase large subunit n=1
           Tax=Hydrogenobaculum sp. Y04AAS1 RepID=LEUC_HYDS0
          Length = 424

 Score =  163 bits (412), Expect = 1e-38
 Identities = 76/188 (40%), Positives = 121/188 (64%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  + +  G++ LKVP +++F+  G++  ++  KDLIL  IG+I V GA Y++
Sbjct: 135 STGVGSTDLAYAMATGEIWLKVPESMKFIFYGKLNKWVSGKDLILYTIGQIGVDGALYRA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + SL++ +R+T+ NM +EAGGK+G+I PD  T +Y+E +   PY+   SD+ A
Sbjct: 195 MEFDGEAIRSLDVSQRLTIANMAIEAGGKSGIISPDEKTIEYVEKRAKKPYKIYQSDKDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++  Y +D + +EP+VA P+ P N     E   + I++ +IGSCT G+ ED   AA + 
Sbjct: 255 HYVEVYEWDASSIEPMVAWPYLPSNVHPVSESTHITIDQAFIGSCTNGRIEDLRIAASIL 314

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 315 ---KGKKV 319

[83][TOP]
>UniRef100_Q9UZ07 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           abyssi RepID=LEUC1_PYRAB
          Length = 423

 Score =  163 bits (412), Expect = 1e-38
 Identities = 78/181 (43%), Positives = 119/181 (65%), Gaps = 2/181 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   +VP T++F+ +GE+  Y+  KDLIL  IG+I V GA YK 
Sbjct: 136 ATGVGSTDLAVAMATGEAWFRVPETMKFIYEGELQPYVTGKDLILHTIGDIGVNGALYKV 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GS +E L++E+RMT+ NM +EAG K G+I PD  T  Y++ +    ++   SD+ A
Sbjct: 196 MEFSGSVIEELSVEQRMTMSNMAIEAGAKTGIIEPDKKTLDYVKERAKRKFKVYKSDEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRA-LARECK-DVKINRVYIGSCTGGKTEDFMAAAK 536
           ++     +DVT  EP+VA PH P+N   +++  K ++KI++V+IGSCT G+ ED   AA+
Sbjct: 256 KYYKVIEYDVTNWEPVVAFPHLPENTVPISKAAKMNIKIDQVFIGSCTNGRIEDLRMAAE 315

Query: 537 V 539
           +
Sbjct: 316 I 316

[84][TOP]
>UniRef100_Q2LWJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Syntrophus
           aciditrophicus SB RepID=LEUC_SYNAS
          Length = 420

 Score =  162 bits (411), Expect = 1e-38
 Identities = 81/179 (45%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G++  KVP ++RFV+ G +  ++  KDLIL IIG+I V GA YK+
Sbjct: 136 ATGVGSTDLAAAMLTGEVWFKVPESIRFVLSGTLNPWVSGKDLILYIIGKIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G T+ SL M +R T+ NM +EAGGKNG+  PD +T  Y++ +   PY    SD  A
Sbjct: 196 MEFTGDTIASLTMADRFTIANMAIEAGGKNGIFTPDEITEAYVKPRAKRPYTFYASDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +      DV ++EP VA PH P N     E   V +++V IGSCT G+ ED  AAA V
Sbjct: 256 AYAQVIEIDVNRIEPQVAFPHLPSNTKGISEVGQVPLDQVVIGSCTNGRIEDLRAAAAV 314

[85][TOP]
>UniRef100_C5CJ10 Homoaconitate hydratase family protein n=1 Tax=Kosmotoga olearia
           TBF 19.5.1 RepID=C5CJ10_KOSOT
          Length = 417

 Score =  162 bits (410), Expect = 2e-38
 Identities = 82/181 (45%), Positives = 115/181 (63%), Gaps = 2/181 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD     G GK+ LKVP +L+FV++G++PD + +KD+IL IIG I   GA YK 
Sbjct: 131 ATGMGSTDVALAFGLGKVWLKVPASLKFVLNGKIPDGVFSKDIILHIIGLIGADGANYKV 190

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE--GKTSVPYESVYSDQ 356
           MEF G  +E ++ E R T+ NM +EAG K+G+I PD  T  +L   G+ S  Y  + SD 
Sbjct: 191 MEFEGEVIEQISQEARFTITNMAIEAGAKSGIIAPDEKTRAFLRAYGRES-DYREIKSDP 249

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A +   Y  DV+ LEP VA PH+ DN     E + +KI++V+IG+CT G+ ED   AA 
Sbjct: 250 DAVYEKIYEIDVSNLEPAVALPHTVDNTKSISEVEGIKIDQVFIGTCTNGRLEDLRVAAS 309

Query: 537 V 539
           +
Sbjct: 310 I 310

[86][TOP]
>UniRef100_Q2RG98 3-isopropylmalate dehydratase large subunit n=1 Tax=Moorella
           thermoacetica ATCC 39073 RepID=LEUC_MOOTA
          Length = 421

 Score =  162 bits (410), Expect = 2e-38
 Identities = 79/179 (44%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+L  KVP T+ F   G++  ++  KDLIL  IG I V GA Y +
Sbjct: 136 ATGVGSTDLAAAMATGELWFKVPETILFRYHGKLKPWVGGKDLILYTIGRIGVDGARYMA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + +L+ME R T+ NM +EAGGKNG+ P D  T +Y+ G+    Y    SD  A
Sbjct: 196 MEFTGEAITNLSMEGRFTMANMAIEAGGKNGIFPVDEKTVEYIRGRLQRDYRIYQSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           R+  E   D +K+EP VA PH P+N    +E  ++KI++V IGSCT G+ ED   AA++
Sbjct: 256 RYNQEIDIDASKIEPQVALPHLPENARSVKEIGEIKIDQVVIGSCTNGRLEDLRVAAQI 314

[87][TOP]
>UniRef100_Q8TVF2 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Methanopyrus
           kandleri RepID=LEUC1_METKA
          Length = 418

 Score =  162 bits (410), Expect = 2e-38
 Identities = 79/179 (44%), Positives = 113/179 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   GKL  +VP T R  + GE+P+ + AKD++L++ GEI   GATY +
Sbjct: 134 ATGIGSTDMAAVFATGKLWFRVPETYRVEITGELPEGVYAKDVVLKVTGEIGADGATYMA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +E+ G  V  +++ +RM LCNM +E G K G++PPD  T +Y++ +       V  D  A
Sbjct: 194 IEYHGEVVREMSVSDRMCLCNMAIEMGAKTGMVPPDEKTLEYVKKRAGTEGRPVEPDPDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           R+ +E   DV+ LEP VAKP SPDN     E + + I++V+IGSCT G+ ED   AA+V
Sbjct: 254 RYEAELTLDVSDLEPQVAKPFSPDNVVPVGEVEGIAIDQVFIGSCTNGRYEDLKVAAEV 312

[88][TOP]
>UniRef100_B5YKE0 3-isopropylmalate dehydratase large subunit n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=LEUC_THEYD
          Length = 421

 Score =  162 bits (409), Expect = 2e-38
 Identities = 78/188 (41%), Positives = 119/188 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TDA   +  G+   KVP T++F+  G++  ++  KDLIL  IG+I V GA+Y +
Sbjct: 136 ATGVGSTDAAIAMATGECWFKVPETIKFIYYGKLQKWVSGKDLILYTIGDIGVDGASYMA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF+G  ++++ M  R ++CNM +EAG K G+I PD +T +Y++ +   PY+   SDQ A
Sbjct: 196 MEFIGEVIDNMPMSGRFSMCNMAIEAGAKAGIIVPDKITEEYVKLRAKRPYKIYNSDQDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++     +D +++ P+VA PH P N   A E   +KI++V IGSCT G+ ED   AA V 
Sbjct: 256 KYFEIKEYDCSRIPPVVACPHLPSNVKPANELSHIKIDQVVIGSCTNGRLEDLREAAMVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[89][TOP]
>UniRef100_A8AB09 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ignicoccus
           hospitalis KIN4/I RepID=A8AB09_IGNH4
          Length = 419

 Score =  161 bits (407), Expect = 4e-38
 Identities = 86/198 (43%), Positives = 124/198 (62%), Gaps = 4/198 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG +D   V   GKL  KVP +++  + GE+P  + AKD+IL IIG +TV GATYK+
Sbjct: 136 ATGIGASDMAMVWLTGKLWFKVPESIKVNVTGELPKGVYAKDVILHIIGTVTVDGATYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +E+ G T++ +N+ +RMTL NM VE G K G++P D VT K+ E +  +  +    D  A
Sbjct: 196 VEYHGDTIKRMNIADRMTLANMSVEMGAKAGMVPADEVTVKFFE-EAGISVKPFGPDPGA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   + FDV+KLEP VA PHS DN     E +   I++ +IGSCT G+ EDF+ AAK+ 
Sbjct: 255 QYEDVWEFDVSKLEPQVAVPHSVDNVVAVGEVEGTPIDQAFIGSCTNGRYEDFVEAAKIL 314

Query: 543 ----LASGGKKVKVPTFL 584
               +A G + + +P  L
Sbjct: 315 KGRKVAPGVRCIAIPASL 332

[90][TOP]
>UniRef100_C7P7J9 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           fervens AG86 RepID=C7P7J9_METFA
          Length = 424

 Score =  161 bits (407), Expect = 4e-38
 Identities = 82/190 (43%), Positives = 116/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   GKL  KVP T+ F + G++  Y+ +KD+IL IIGE+ V GATYK+
Sbjct: 135 ATGIGSTDMAHVFATGKLWFKVPETIYFNITGDLQPYVTSKDVILSIIGEVGVDGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-----TSVPYESVY 347
            +F G TV+ +++  RMT+ NM +E GGK G+I PD  T +Y++       T  P+E + 
Sbjct: 195 CQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTVQYVKEAMKKHGTERPFEIIK 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F   Y  +  K+EP+ A PH+ DN   ARE     I++V+IGSCT G+ ED   
Sbjct: 255 GDEDAEFAEVYEIEADKIEPVFACPHNVDNVKPAREVAGRPIDQVFIGSCTNGRFEDLKM 314

Query: 528 AAKVFLASGG 557
           A ++    GG
Sbjct: 315 AIEIIDKHGG 324

[91][TOP]
>UniRef100_Q6LY44 3-isopropylmalate dehydratase n=1 Tax=Methanococcus maripaludis
           RepID=Q6LY44_METMP
          Length = 424

 Score =  160 bits (406), Expect = 5e-38
 Identities = 82/190 (43%), Positives = 116/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD       G+L  KVP TL F + GE+   +++KD+IL IIG +   GATYK+
Sbjct: 135 ATGIGSTDMAAAFATGELWFKVPETLYFNITGELKPEVMSKDVILSIIGMVGADGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE-----GKTSVPYESVY 347
            +F G+TV+++ +  RMT+ NM +E GGK G+I PD  T  Y++       T+ P+E V 
Sbjct: 195 AQFAGNTVDNMTIASRMTMSNMAIEMGGKAGLIAPDDKTINYVKNAMEANNTAKPFELVL 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F  ++  DV+ LEP++A PH+ DN    RE     I++V+IGSCT G+ ED  A
Sbjct: 255 GDKNAEFEEKFEIDVSNLEPVMACPHNVDNVKAVREVAGTPIDQVFIGSCTNGRLEDLRA 314

Query: 528 AAKVFLASGG 557
           A  V    GG
Sbjct: 315 ALNVIEKHGG 324

[92][TOP]
>UniRef100_A4FX22 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanococcus
           maripaludis C5 RepID=A4FX22_METM5
          Length = 424

 Score =  160 bits (406), Expect = 5e-38
 Identities = 81/190 (42%), Positives = 117/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD       G+L  KVP TL F + GE+   +++KD+IL IIG +   GATYK+
Sbjct: 135 ATGIGSTDMAAAFATGELWFKVPETLYFNITGELKPEVMSKDVILSIIGMVGADGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE-----GKTSVPYESVY 347
            +F G+TV+++ +  RMT+ NM +E GGK G+I PD  T  Y++       T+ P+E + 
Sbjct: 195 AQFAGNTVDNMTIASRMTMSNMAIEMGGKAGLIAPDDKTINYVKNAMEMNNTAKPFEFIL 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F  ++  DV+ LEP++A PH+ DN    RE     I++V+IGSCT G+ ED  A
Sbjct: 255 GDKDAEFEKKFEIDVSNLEPVMACPHNVDNVKAVREVAGTPIDQVFIGSCTNGRLEDLRA 314

Query: 528 AAKVFLASGG 557
           A +V    GG
Sbjct: 315 ALEVIEKHGG 324

[93][TOP]
>UniRef100_A9KT79 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           phytofermentans ISDg RepID=LEUC_CLOPH
          Length = 421

 Score =  160 bits (406), Expect = 5e-38
 Identities = 80/188 (42%), Positives = 120/188 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD G  +  GK   KVP  ++F++ GE  +++  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMGAGMITGKAWFKVPAAIKFILTGEPKEWVSGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG+ +++L M++R T+ NM +EAG KNG+ P D +T  Y++   + PY    +D+ A
Sbjct: 196 MEFVGAGIKNLTMDDRFTIANMAIEAGAKNGIFPVDDLTISYMKEHGAKPYTIYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      ++++LEP VA PH P+N    +E  +V+I++V IGSCT G+  D   AAKV 
Sbjct: 256 EYEQIITINLSELEPTVAFPHLPENTKTVKEAGEVRIDQVVIGSCTNGRIGDLRIAAKVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---EGRKV 320

[94][TOP]
>UniRef100_C7H4B6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Faecalibacterium prausnitzii A2-165
           RepID=C7H4B6_9FIRM
          Length = 419

 Score =  160 bits (405), Expect = 7e-38
 Identities = 88/198 (44%), Positives = 118/198 (59%), Gaps = 7/198 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G    KVP  ++FV+ G+    +  KDLIL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGMAWFKVPSAIKFVLKGKFSPRVSGKDLILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG---KTSVPYESVYSD 353
           MEF G  V SL ME+R+ +CNM +EAG KNG+ P D VT  YL G   +T V YE   +D
Sbjct: 196 MEFTGPGVASLTMEDRLCVCNMAIEAGAKNGIFPVDEVTRAYLNGRSQRTPVYYE---AD 252

Query: 354 QQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAA 533
             A +      D+ KLEP V+ PH P+N   A E KD++I++V IGSCT G+ ED  AA 
Sbjct: 253 PDAEYEKTIEIDLDKLEPTVSYPHLPENTHPASEGKDIRIDQVVIGSCTNGRLEDMEAAY 312

Query: 534 KVF----LASGGKKVKVP 575
            +     +A G + + +P
Sbjct: 313 NILKGKHIAKGVRGIIIP 330

[95][TOP]
>UniRef100_C4G1B4 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1B4_ABIDE
          Length = 421

 Score =  160 bits (405), Expect = 7e-38
 Identities = 80/188 (42%), Positives = 119/188 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++FV+ G+M  ++  KD+IL IIG+I V GA YKS
Sbjct: 136 STGVGSTDMAAGMVTGKAWFKVPSAIKFVLTGKMKKWVSGKDVILHIIGKIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L M++R T+ NM +EAG KNG+ P D +T  Y++  ++ PY+   +D+ A
Sbjct: 196 MEFTGDGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTLNYIKEHSTKPYKVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      ++++LEP VA PH P+N     E  D+KI++V IGSCT G+  D   AA+V 
Sbjct: 256 VYDEVIEINLSELEPTVAFPHLPENTRTIGETGDIKIDQVVIGSCTNGRISDIRVAAEVM 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[96][TOP]
>UniRef100_A6VG92 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C7 RepID=A6VG92_METM7
          Length = 424

 Score =  160 bits (405), Expect = 7e-38
 Identities = 81/190 (42%), Positives = 117/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   G+L  KVP TL F + GE+   +++KD+IL IIG +   GATYK+
Sbjct: 135 ATGIGSTDMAAVFATGELWFKVPETLYFNISGELKPEVMSKDVILSIIGMVGADGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE-----GKTSVPYESVY 347
            +F G+TV+++ +  RM++ NM +E GGK G+I PD  T  Y++       T+ P+E + 
Sbjct: 195 AQFAGNTVDNMTIASRMSMSNMAIEMGGKAGLIAPDDKTINYVKNAMETNNTAKPFEFIL 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F  ++  +V  LEP++A PH+ DN    RE     I++V+IGSCT G+ ED  A
Sbjct: 255 GDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKTVREVAGTPIDQVFIGSCTNGRIEDLRA 314

Query: 528 AAKVFLASGG 557
           A KV    GG
Sbjct: 315 ALKVIEKHGG 324

[97][TOP]
>UniRef100_C4ZBK5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Eubacterium
           rectale ATCC 33656 RepID=C4ZBK5_EUBR3
          Length = 420

 Score =  160 bits (404), Expect = 9e-38
 Identities = 81/188 (43%), Positives = 118/188 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F + G+  +++  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGKAWFKVPSAIKFNIVGKPAEWISGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D +T +Y++  +  P+    +D  A
Sbjct: 196 MEFVGDGLKYLSMDDRFTIANMAIEAGGKNGIFPVDDLTREYMKEHSKRPFTEYEADSDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  EY  D++ L+  V+ PH PDN     E  DVKI++V IGSCT G+ +D   AAK+ 
Sbjct: 256 EYDEEYTIDLSTLKSTVSFPHLPDNTRTIDEVGDVKIDQVVIGSCTNGRMDDLRIAAKIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---EGKKV 320

[98][TOP]
>UniRef100_Q2NE97 LeuC1 n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NE97_METST
          Length = 418

 Score =  160 bits (404), Expect = 9e-38
 Identities = 79/178 (44%), Positives = 117/178 (65%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TGIG+TD   V   G+L  KVP TL+F + G++ + + +KD+IL IIG+I   GA YK+ 
Sbjct: 136 TGIGSTDMAMVFATGQLWFKVPETLQFNVTGDLKENVTSKDVILNIIGQIGQDGARYKAC 195

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           E+ G TV++++M +RM L NM +E GGK G++P D +T +YL+ +T+  Y    +D+ A 
Sbjct: 196 EYTGETVQNMDMSDRMVLSNMAIECGGKTGIVPADKITDEYLKNRTTKQYTKFTTDKDAA 255

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            L     DV+ LEP VA P+  DN   A E +DV+I++V+IGSCT G+ +D   AA+V
Sbjct: 256 SLEVMDIDVSDLEPQVACPNYVDNVKPASEVEDVEIDQVFIGSCTNGRLKDLEQAARV 313

[99][TOP]
>UniRef100_A8S7H1 Putative uncharacterized protein n=1 Tax=Faecalibacterium
           prausnitzii M21/2 RepID=A8S7H1_9FIRM
          Length = 419

 Score =  159 bits (403), Expect = 1e-37
 Identities = 83/195 (42%), Positives = 116/195 (59%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G    KVP  ++FV+ G+    +  KDLIL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGMAWFKVPSAIKFVLTGKFNPRVSGKDLILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V  L M++R+ +CNM +EAG KNG+ P D VT  YL G++  P     +D  A
Sbjct: 196 MEFTGPGVAGLTMDDRLCICNMAIEAGAKNGIFPVDEVTKAYLAGRSQRPPVFYEADPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++ LEP V+ PH P+N  +A E KD+KI++V IGSCT G+ ED  AA  + 
Sbjct: 256 VYEKTIEIDLSALEPTVSYPHLPENTHVASEGKDIKIDQVVIGSCTNGRLEDMEAAYNIL 315

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 316 KGKHIAKGVRGIIIP 330

[100][TOP]
>UniRef100_A7IA28 3-isopropylmalate dehydratase large subunit n=1 Tax=Candidatus
           Methanoregula boonei 6A8 RepID=LEUC_METB6
          Length = 416

 Score =  159 bits (402), Expect = 2e-37
 Identities = 81/187 (43%), Positives = 117/187 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD GF L  G L  KVP T+R  + G+    + AKDLIL I  +I   GATY++
Sbjct: 133 ATGIGSTDMGFALKFGALYFKVPETVRAEISGKFQKRVGAKDLILSIAADIGADGATYQA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G T+  ++M  RMT CNM +E G K G++PPD VT++Y++G+  +   ++ SD  A
Sbjct: 193 IEFTGKTISKMDMAGRMTCCNMAIEMGAKAGIVPPDKVTWEYMKGRRKITPFALASDDDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           +F  +  ++V  LEP VA PH+ D      + +   I++V+IGSCT G+ ED + AA+V 
Sbjct: 253 KFAEKRTYNVADLEPQVAVPHNVDQGIPVGKVEGTHIDQVFIGSCTNGRYEDLVEAAEVL 312

Query: 543 LASGGKK 563
               GKK
Sbjct: 313 ----GKK 315

[101][TOP]
>UniRef100_B9L0Y1 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0Y1_THERP
          Length = 422

 Score =  159 bits (401), Expect = 2e-37
 Identities = 79/179 (44%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G   ++VP T++FV  G +P ++  KDLIL  IG+I V GA Y  
Sbjct: 138 ATGMGSTDIAAAMATGTTWMRVPQTIKFVYTGTLPPFVTGKDLILYTIGQIGVDGALYAC 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  ++ L M++R+T+ NM +EAG K G+   D  T ++L   T+ PYE V SD  A
Sbjct: 198 MEFTGPVIDQLPMDDRITMANMAIEAGAKTGIFACDDKTREWLAKVTTEPYEPVDSDPDA 257

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           R+     FDV+ L PLVA PH P N   A E +D+ I++V IGSCT G+  D   AA++
Sbjct: 258 RYAQIIEFDVSNLRPLVALPHLPSNVRPADEVRDLPIDQVVIGSCTNGRLSDLRIAAEI 316

[102][TOP]
>UniRef100_O28316 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Archaeoglobus
           fulgidus RepID=LEUC1_ARCFU
          Length = 418

 Score =  159 bits (401), Expect = 2e-37
 Identities = 83/197 (42%), Positives = 122/197 (61%), Gaps = 6/197 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD GFVL  GKL  KVP ++RF + G++  ++  KD++L++IG +   GA YK+
Sbjct: 134 ATGIGSTDMGFVLAMGKLWFKVPESIRFNVHGKLEKHVYGKDIVLKLIGMVGADGANYKA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYES--VYSDQ 356
             + G  VE L M +R+T+CNM +E GGK G++ PD  T +YL+     PYE   + SD+
Sbjct: 194 CIYSGEVVEKLGMSDRLTMCNMAIEMGGKAGIVEPDKTTLEYLKA-MGRPYEGELLKSDE 252

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A F  E   DVT +EP VA PH  DN     E +  ++++V+IGSCT G+ ED   AA+
Sbjct: 253 DAEF-QEVELDVTGMEPQVAAPHRVDNVVGISEVEGTRVDQVFIGSCTNGRYEDLKIAAE 311

Query: 537 VF----LASGGKKVKVP 575
           +     +AS  + + +P
Sbjct: 312 ILKGEKVASNVRLIVIP 328

[103][TOP]
>UniRef100_Q3AEQ4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AEQ4_CARHZ
          Length = 421

 Score =  158 bits (400), Expect = 3e-37
 Identities = 81/190 (42%), Positives = 121/190 (63%), Gaps = 1/190 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGE-MPDYLLAKDLILQIIGEITVAGATYK 179
           ATG+G+TD    +  G+   KVP +++F + GE +  Y+ AKD+IL IIG+I V GA YK
Sbjct: 136 ATGVGSTDLAAAMALGETWFKVPESIKFYLYGEKLLPYVSAKDIILFIIGQIGVDGALYK 195

Query: 180 SMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQ 359
           +MEF GS ++ +++E R+T+ NM +EAG KNG+ P D +T +Y++G+    ++   SD  
Sbjct: 196 AMEFAGSALKLISVEGRLTMANMAIEAGAKNGIFPVDELTLEYVKGRAKREFKVFASDPD 255

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           AR+ + Y  +V ++EP VA PH P+N    +E     I++V IGSCT G+ ED   AA +
Sbjct: 256 ARYEAVYEINVEEIEPQVALPHLPENAVPVKEVSGKDIDQVVIGSCTNGRIEDLRVAAAI 315

Query: 540 FLASGGKKVK 569
                GKKVK
Sbjct: 316 L---KGKKVK 322

[104][TOP]
>UniRef100_C1TNL5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNL5_9BACT
          Length = 419

 Score =  158 bits (400), Expect = 3e-37
 Identities = 83/188 (44%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD       G+  L VPPT+R    G +  ++  KDLIL ++ EI+V GA Y +
Sbjct: 134 STGMGSTDLAGAWATGETWLMVPPTVRIDFRGSISRHITGKDLILAVLREISVQGARYMA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  + S++M+ R T+ NM VEAGGK G+  PD  T  Y E + S P+ + Y D+  
Sbjct: 194 LEFGGDALASMSMDHRFTVANMAVEAGGKAGLFVPDETTLAYAEARASRPFTARYPDEGC 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      DV KL PLVA PHSPDN   A    D +I +V+IGSCT G+ ED  AAA V 
Sbjct: 254 EYAKRVEIDVEKLTPLVAAPHSPDNVRPASTFGDTEIQQVFIGSCTNGRLEDMAAAASVL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---EGKKV 318

[105][TOP]
>UniRef100_B4WHZ3 3-isopropylmalate dehydratase, large subunit subfamily n=1
           Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ3_9SYNE
          Length = 567

 Score =  158 bits (400), Expect = 3e-37
 Identities = 79/177 (44%), Positives = 111/177 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD   +   G L ++VP TLR  + G++P+ + AKD++L I+G+I   GAT   
Sbjct: 285 STGVGTTDMANIFAMGDLWIRVPATLRIELSGKLPELVSAKDIMLFILGQIGCHGATGTV 344

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GS VE L M+ERMTL NMV+E G   G++P D  T +Y++  T+ P+  V +D  A
Sbjct: 345 VEFAGSVVEQLPMDERMTLANMVIECGAMCGLMPVDQTTREYVKAHTNQPFTEVTADLDA 404

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAA 533
           ++   YRFD+++L P VA P +PD      E   V I R +IGSCTGGK  D  AAA
Sbjct: 405 QYEQSYRFDLSQLTPQVAAPPTPDRVVPVHELDGVAITRAFIGSCTGGKLHDLAAAA 461

[106][TOP]
>UniRef100_B0PBC0 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PBC0_9FIRM
          Length = 419

 Score =  158 bits (400), Expect = 3e-37
 Identities = 80/188 (42%), Positives = 115/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG G+TD   V+  GK   KVP  +RF + G+  +++  KD+IL IIG I V GA Y+S
Sbjct: 136 STGFGSTDMAAVMATGKCWFKVPAAIRFELSGKPQEWVSGKDVILHIIGMIGVDGALYQS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +  L+M++R+T+ NM +EAGGKNG+   D VT  Y++G+ +  YE+   D  A
Sbjct: 196 MEFGGEGLRHLSMDDRLTMANMAIEAGGKNGIFEVDEVTRAYMQGRVNRTYETFMPDDGA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++ + P VA PH P+N     E  DV+I++V IGSCT G+  D  AAA++ 
Sbjct: 256 AYARVIEIDLSSIRPTVAFPHLPENTRTVDEAGDVRIDQVVIGSCTNGRIGDLAAAARLM 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---SGKKV 320

[107][TOP]
>UniRef100_A5ZAM9 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum
           ATCC 27560 RepID=A5ZAM9_9FIRM
          Length = 421

 Score =  158 bits (400), Expect = 3e-37
 Identities = 77/179 (43%), Positives = 113/179 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F + G+   ++  KD+IL IIG I V GA Y+S
Sbjct: 136 STGVGSTDMAAGMATGKAWFKVPSAIKFNLTGKPAKWVSGKDVILHIIGLIGVDGALYRS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L+M++R  + NM +EAGGKNG+ P D +T +Y++  ++  Y    +D+ A
Sbjct: 196 MEFVGDGIKYLSMDDRFAMTNMAIEAGGKNGIFPVDDLTIEYMKEHSTKEYTVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +  EY  D++ L P VA PH P+N     E  DVKI++V IGSCT G+ ED   AAK+
Sbjct: 256 EYDEEYTIDLSTLRPTVAFPHLPENTRTIDEVGDVKIDQVVIGSCTNGRIEDMRTAAKI 314

[108][TOP]
>UniRef100_Q0AV21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Syntrophomonas
           wolfei subsp. wolfei str. Goettingen RepID=Q0AV21_SYNWW
          Length = 419

 Score =  157 bits (398), Expect = 4e-37
 Identities = 76/179 (42%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVP +++FV  G +P ++  KDLIL  IG+I V GA Y S
Sbjct: 136 ATGVGSTDMAAGMATGEAWFKVPESIKFVYYGHLPRWVGGKDLILHTIGDIGVDGARYMS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L+M+ R T+ NM +EAGGKNG+   D +T  Y++ +   P+E   SD  A
Sbjct: 196 MEFTGEVIQNLSMDNRFTMANMAIEAGGKNGIFAADEITLDYVKKRVKRPFELYQSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +     +DV+KLEP+VA PH P+N     E   V +++V IGSCT G+ ED    A +
Sbjct: 256 VYFDIKEYDVSKLEPVVAFPHLPENTRPVTEATHVSLDQVVIGSCTNGRIEDMEITASL 314

[109][TOP]
>UniRef100_Q24XT4 3-isopropylmalate dehydratase large subunit n=2
           Tax=Desulfitobacterium hafniense RepID=LEUC_DESHY
          Length = 421

 Score =  157 bits (398), Expect = 4e-37
 Identities = 76/180 (42%), Positives = 113/180 (62%), Gaps = 1/180 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDG-EMPDYLLAKDLILQIIGEITVAGATYK 179
           ATG+G+TD    +  G+   ++P +++F+  G     ++  KDLIL  IG+I V GA Y+
Sbjct: 136 ATGVGSTDLAAGMATGEAWFRIPESIKFIFKGTNFQPWVSGKDLILYTIGKIGVDGARYR 195

Query: 180 SMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQ 359
           SMEF G  + +L+M+ R+T+CNM VEAG KNG+IPPD  T  Y+  +   PY+  +SD  
Sbjct: 196 SMEFTGEGIAALSMDGRLTMCNMAVEAGAKNGIIPPDEKTLAYVNERAKRPYKVYHSDPD 255

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A+++  Y +DV  +   VA PH P+N     E K +KI++V IGSCT G+ ED   AA++
Sbjct: 256 AQYVEVYEWDVADIPLQVAFPHLPENAKPVSEGKGIKIDQVVIGSCTNGRLEDMQVAAQI 315

[110][TOP]
>UniRef100_Q0W1Q4 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W1Q4_UNCMA
          Length = 414

 Score =  157 bits (398), Expect = 4e-37
 Identities = 78/194 (40%), Positives = 118/194 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G TD   +  +GKL  +VP T++  +DG++P  +  KD+IL+I  E+   GATYK+
Sbjct: 133 ATGVGATDMAEIYTSGKLWFRVPETIKLTVDGKLPAAVTPKDVILRIAKEVGSDGATYKA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  ++ +++  RMTLCNM +E GGK G++PPD  T+ +L+G+    Y  VY+ + A
Sbjct: 193 MEFYGPVIDHMSIAGRMTLCNMAIEMGGKAGIVPPDEKTFAFLKGRAVEEYRPVYASRDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  E   DV+KL P V+ P   DN     E +   +++V IGSCT G+ ED   AA + 
Sbjct: 253 VYCDELHLDVSKLHPQVSCPPDVDNVKDVGEVEGTHVDQVLIGSCTNGRYEDLAGAAAIL 312

Query: 543 LASGGKKVKVPTFL 584
               G+KV+  T +
Sbjct: 313 ---KGRKVRCRTLI 323

[111][TOP]
>UniRef100_A6UTQ6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           aeolicus Nankai-3 RepID=A6UTQ6_META3
          Length = 425

 Score =  157 bits (398), Expect = 4e-37
 Identities = 82/190 (43%), Positives = 117/190 (61%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   G+L  KVP TL F + G++ D++ +KD+IL+IIGE+   GATYK+
Sbjct: 136 ATGIGSTDMAAVFATGELWFKVPETLYFNVSGKLNDFVTSKDVILKIIGEVGFDGATYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-----TSVPYESVY 347
            ++ G TVE +++  RMT+ NM +E G K G+I PD  T  +++       T+ PY ++ 
Sbjct: 196 AQYGGETVEEMSISSRMTMSNMAIEMGAKAGLIEPDVKTTYFIKRAMQKHGTTRPYTALK 255

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A+F   Y  +V  LEPL A PH+ DN   ARE     I++V+IGSCT G+ ED  A
Sbjct: 256 GDEDAKFEETYEIEVNDLEPLFACPHAVDNVKTAREVAGRPIDQVFIGSCTNGRVEDLRA 315

Query: 528 AAKVFLASGG 557
           A  +    GG
Sbjct: 316 AINIIDQHGG 325

[112][TOP]
>UniRef100_Q7M9Z9 3-isopropylmalate dehydratase large subunit n=1 Tax=Wolinella
           succinogenes RepID=LEUC_WOLSU
          Length = 422

 Score =  157 bits (397), Expect = 6e-37
 Identities = 82/192 (42%), Positives = 126/192 (65%), Gaps = 4/192 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  + +  GK   KVPP++R V  G++ +++  KDLIL+II +I V GA YK+
Sbjct: 135 ATGMGSTDLAYAMITGKNWFKVPPSIRVVFKGKLQEHVYGKDLILEIIRQIGVDGALYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVY--SDQ 356
           +EF G T+E L+M++R +LCNM +EAG KNG+I  DS+T ++L  + S+  E  Y  +D 
Sbjct: 195 LEFQGDTIEQLSMDDRFSLCNMAIEAGAKNGIIAADSITKEFLASRKSLRAEPKYYQADA 254

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINRVYIGSCTGGKTEDFMAA 530
            A +      DV KLEP++A P  P N +++++  K D+KI++ +IGSCT G+  D   A
Sbjct: 255 DALYEQTIEIDVEKLEPVIAYPFLPSNGKSISQAVKDDLKIDQAFIGSCTNGRLSDLRIA 314

Query: 531 AKVFLASGGKKV 566
           A++     GK+V
Sbjct: 315 AQIL---KGKRV 323

[113][TOP]
>UniRef100_Q8TQZ3 3-isopropylmalate dehydratase large subunit 2 n=1
           Tax=Methanosarcina acetivorans RepID=LEUC2_METAC
          Length = 420

 Score =  157 bits (397), Expect = 6e-37
 Identities = 84/199 (42%), Positives = 124/199 (62%), Gaps = 8/199 (4%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD   V   GKL  +VP T RF ++G++P+ + +KDLIL +IG++ V GA Y +
Sbjct: 135 STGIGSTDMAAVFATGKLWFRVPETFRFEVEGKLPERVYSKDLILHLIGDVGVEGARYMA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE----GKTSVPYESVYS 350
            E+ GST+ SL++ ERMT+ NM +E GGK G+I  D VT  YL+    G    PY    S
Sbjct: 195 AEYAGSTIRSLSIPERMTISNMAIEMGGKAGIIEADEVTEAYLQERIPGYKLDPYWK--S 252

Query: 351 DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAA 530
           D++A++L    +DV+ LEP VA PH+ DN     E +  K+++V++GSCT G+ ED    
Sbjct: 253 DEEAKYLDIRHYDVSDLEPQVACPHNVDNVKSVSEVEGTKLDQVFMGSCTNGRFEDIKIM 312

Query: 531 AKVF----LASGGKKVKVP 575
           A +     +A G + + VP
Sbjct: 313 ADIMGDEPVAKGVRLLVVP 331

[114][TOP]
>UniRef100_A9AAG0 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C6 RepID=A9AAG0_METM6
          Length = 424

 Score =  157 bits (396), Expect = 8e-37
 Identities = 79/190 (41%), Positives = 115/190 (60%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   G+L  KVP T  F + GE+   +++KD+IL IIG +   GATYK+
Sbjct: 135 ATGIGSTDMAAVFATGELWFKVPETFYFNISGELKPEVMSKDVILSIIGMVGADGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE-----GKTSVPYESVY 347
            +F G+TV+++ +  RM++ NM +E GGK G+I PD  T  Y++       T+ P+E + 
Sbjct: 195 AQFAGNTVDNMTIASRMSMSNMAIEMGGKAGLIAPDDKTINYVKNAMETNNTAKPFEFIL 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F  ++  +V  LEP++A PH+ DN    RE     I++V+IGSCT G+ ED  A
Sbjct: 255 GDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKAVREVAGTPIDQVFIGSCTNGRIEDLRA 314

Query: 528 AAKVFLASGG 557
           A  V    GG
Sbjct: 315 ALNVIEKHGG 324

[115][TOP]
>UniRef100_A8SZ55 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SZ55_9FIRM
          Length = 461

 Score =  156 bits (395), Expect = 1e-36
 Identities = 78/195 (40%), Positives = 121/195 (62%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  ++F + GE   ++  KD+IL IIG I V GA YKS
Sbjct: 176 STGVGSTDMAAGMVTGEAWFKVPSAIKFNIVGEKAKWISGKDVILHIIGMIGVDGALYKS 235

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +++L M++R T+ NM +EAG KNG+ P D +T +Y++  ++  Y    +D+ A
Sbjct: 236 MEFVGEGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTEEYMKEHSTKSYTKYEADEDA 295

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + +EY  D+++L+P VA PH P+N     E  D+KI++V IGSCT G+  D   AA + 
Sbjct: 296 VYDAEYTIDLSQLKPTVAFPHLPENTKTIDEVGDIKIDQVVIGSCTNGRISDMRIAADII 355

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 356 KGRKVADGVRVIVIP 370

[116][TOP]
>UniRef100_B2J8P2 Homoaconitate hydratase family protein n=1 Tax=Nostoc punctiforme
           PCC 73102 RepID=B2J8P2_NOSP7
          Length = 569

 Score =  155 bits (393), Expect = 2e-36
 Identities = 81/195 (41%), Positives = 116/195 (59%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD   +   G + +++PPTL F + G +P  + AKD+IL I+G+I  AGAT K 
Sbjct: 287 STGVGTTDMANIYATGDMWIRIPPTLVFELSGTLPPKISAKDIILFILGQIGCAGATSKV 346

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GS +  L  +ER+TL NM VE G   G+I PD VT +YL+ + S  ++ +  D  A
Sbjct: 347 MEFRGSILAQLPFDERLTLANMAVECGAICGLIVPDEVTREYLKNRVSEEFQEIIGDADA 406

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y+FD++ LEP VA+P  PD      + +++ I + +IGSCTGGK  D   AA+V 
Sbjct: 407 EYERVYQFDLSSLEPQVARPPKPDRVVAISQLENIPITKAFIGSCTGGKLYDLAQAAEVL 466

Query: 543 ----LASGGKKVKVP 575
               LA G     VP
Sbjct: 467 KGRQLADGVNLFIVP 481

[117][TOP]
>UniRef100_C6LJ75 3-isopropylmalate dehydratase, large subunit n=1 Tax=Bryantella
           formatexigens DSM 14469 RepID=C6LJ75_9FIRM
          Length = 422

 Score =  155 bits (393), Expect = 2e-36
 Identities = 79/190 (41%), Positives = 120/190 (63%), Gaps = 1/190 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  +RF + G+  +++  KD+IL IIG I V GA Y+S
Sbjct: 136 STGVGSTDMAAGMATGKAWFKVPSAIRFHLVGKPSEWVSGKDVILHIIGMIGVDGALYRS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V++L+M++R T+ NM +EAGGKNG+ P D +   Y++  +  PY+   +D+ A
Sbjct: 196 MEFTGEGVKNLSMDDRFTIANMAIEAGGKNGIFPVDDLAIAYMKEHSQRPYKIYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +  EY  D++ L+P VA PH P+N + +    +DV I++  IGSCT G+ +D   AAK+
Sbjct: 256 VYDEEYTIDLSALKPTVAFPHLPENTKTIDEITEDVVIDQAVIGSCTNGRIDDLRCAAKI 315

Query: 540 FLASGGKKVK 569
                G+KVK
Sbjct: 316 L---EGRKVK 322

[118][TOP]
>UniRef100_A5UMS7 3-isopropylmalate dehydratase, large subunit, LeuC n=1
           Tax=Methanobrevibacter smithii ATCC 35061
           RepID=A5UMS7_METS3
          Length = 415

 Score =  155 bits (393), Expect = 2e-36
 Identities = 83/188 (44%), Positives = 117/188 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD   V   G L  KVP T RF + GE+ D + AKD+IL IIG++ V G+TYK+
Sbjct: 135 STGIGSTDMAMVFAEGNLWFKVPETNRFEITGELKDNVYAKDVILNIIGQVGVDGSTYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            EF G TV ++++ +RM L NM +E GGK G++ PD  T  Y+E +++  Y+   +D  A
Sbjct: 195 CEFAGETVSNMSISDRMVLTNMAIEMGGKTGLVEPDKKTIDYVESRSNKAYKVFKTDLDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
             L+    DV++LEP VA PH  DN     E  D +I++V++GSCT G+  D   AAK+ 
Sbjct: 255 PSLNIIDIDVSELEPQVACPHHVDNVKAVSEV-DQEIDQVFLGSCTNGRISDLRDAAKIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[119][TOP]
>UniRef100_B8FMM4 3-isopropylmalate dehydratase large subunit n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=LEUC_DESAA
          Length = 419

 Score =  155 bits (393), Expect = 2e-36
 Identities = 78/187 (41%), Positives = 116/187 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G++ LKVP +++FV  G++  ++  KDLIL  IG+I V GA Y +
Sbjct: 136 ATGVGSTDLAAAMITGEVWLKVPESIKFVYKGKLRPHVEGKDLILHTIGDIGVDGALYMA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L M ER+T+ NM +EAGGK G+I PD+ T +Y +G+         SD  A
Sbjct: 196 MEFTGEVIDALPMAERLTMANMAIEAGGKAGIIAPDAKTKEYADGRVIRKPVFYASDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++     +DVT LEP VA PH P+N     +  +V I++V IGSCT G+ ED  +AA++ 
Sbjct: 256 KYAKVIEYDVTDLEPQVAFPHLPENTRPISQVGEVPIHQVIIGSCTNGRIEDMRSAARIL 315

Query: 543 LASGGKK 563
             +   K
Sbjct: 316 TGNKADK 322

[120][TOP]
>UniRef100_O27668 3-isopropylmalate dehydratase large subunit 2 n=1
           Tax=Methanothermobacter thermautotrophicus str. Delta H
           RepID=LEUC2_METTH
          Length = 428

 Score =  155 bits (393), Expect = 2e-36
 Identities = 77/179 (43%), Positives = 109/179 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G TD   V   GK    VP  +R  + GE   ++ AKD+IL IIGEI V GATY+S
Sbjct: 140 ATGMGATDMAMVFATGKTWFMVPEAMRIEVTGEPEGHVYAKDVILHIIGEIGVDGATYRS 199

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G T+ES+++  RMT+CNM VE G KNG++ P+  T  Y+  +T   +    SD+ +
Sbjct: 200 VEFTGDTIESMDVSGRMTICNMAVEMGAKNGIMEPNRQTLDYVRARTGREFRVYSSDEDS 259

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           ++L ++ FDV+ LEP VA P   DN       +   I+  ++GSCT G+ ED   AA+V
Sbjct: 260 QYLEDHHFDVSDLEPQVACPDDVDNVYPVHRVEGTHIDEAFLGSCTNGRYEDLKIAAEV 318

[121][TOP]
>UniRef100_B8I2I1 Homoaconitate hydratase family protein n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I2I1_CLOCE
          Length = 418

 Score =  155 bits (392), Expect = 2e-36
 Identities = 78/179 (43%), Positives = 113/179 (63%), Gaps = 1/179 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD   V   GKL  +VP T + +  GE+P  + AKDL L +IG++ + GA Y  
Sbjct: 135 STGVGSTDMACVWATGKLWFRVPETTKIIFSGELPKGVYAKDLALYLIGQLGINGANYDM 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVY-SDQQ 359
           +EF G  +++L++  R+TLCNMV+E G K G+I  D+VT KY   K     +  + SD  
Sbjct: 195 LEFDGELIKNLDISSRLTLCNMVIEMGAKAGIINADAVTQKYFREKNLKTEDIDFNSDNG 254

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
           AR+      DV+K+EP++A P+SP N   A+E  D+KI++V IGSCT G+ EDF  A K
Sbjct: 255 ARYKKIIEIDVSKIEPVIACPYSPGNIKTAKELVDLKIDQVVIGSCTNGRIEDFRVAHK 313

[122][TOP]
>UniRef100_A1HLS2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HLS2_9FIRM
          Length = 420

 Score =  155 bits (392), Expect = 2e-36
 Identities = 74/179 (41%), Positives = 112/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVPP++R  + G++P ++  KD++L +IG I V GA Y+S
Sbjct: 135 ATGVGSTDMAAAMATGETWFKVPPSIRVELRGQLPRWVGGKDVVLTLIGMIGVDGARYQS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V +L M +R+T+ NM +EAG KNG+ P D  T +YL  +    YE+V  D  A
Sbjct: 195 LEFCGEGVAALTMADRLTIANMAIEAGAKNGIFPVDDATIRYLSTRVERDYEAVSPDADA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            ++     ++  LEP+VA PH P+N   A + +D+ I++V IGSCT G+ ED   AA +
Sbjct: 255 SYVRTVVINLDDLEPVVALPHLPENVRPAAQVRDIAIDQVVIGSCTNGRLEDLAQAAAI 313

[123][TOP]
>UniRef100_Q46AJ7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosarcina
           barkeri str. Fusaro RepID=Q46AJ7_METBF
          Length = 431

 Score =  155 bits (392), Expect = 2e-36
 Identities = 82/197 (41%), Positives = 120/197 (60%), Gaps = 6/197 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD   V   GKL  KVP T RF ++G +P+ + +KDLIL +IG++ V GA Y +
Sbjct: 146 STGIGSTDMAAVFATGKLWFKVPETFRFEVEGNLPERVYSKDLILHLIGDVGVEGARYMA 205

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVY--SDQ 356
            EF GST+ SL++ ERMT+ NM +E GGK G+I  D VT  YL+ +        Y  SD+
Sbjct: 206 AEFGGSTIHSLSIPERMTMSNMAIEMGGKAGIIEADEVTANYLKERIMYYEFDPYWKSDE 265

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A+++    +DV+ LEP VA PH  DN     E +  K++++++GSCT G+ ED    A 
Sbjct: 266 DAKYVGIRHYDVSDLEPQVACPHHVDNVKPVTEVEGTKLDQIFVGSCTNGRFEDIKIMAD 325

Query: 537 VF----LASGGKKVKVP 575
           +     +A G + + VP
Sbjct: 326 IMGDEPVAKGVRLLVVP 342

[124][TOP]
>UniRef100_C5U763 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           infernus ME RepID=C5U763_9EURY
          Length = 424

 Score =  155 bits (392), Expect = 2e-36
 Identities = 80/190 (42%), Positives = 113/190 (59%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   G+L  KVP T+ F + GE+  Y+ +KD+IL IIGE+ V GATYK+
Sbjct: 135 ATGIGSTDMAHVFATGELWFKVPETIYFNITGELKPYVTSKDVILSIIGEVGVDGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-----TSVPYESVY 347
            +F G TV+++++  RMT+ NM +E GGK G+I PD  T  Y++       T   ++ + 
Sbjct: 195 CQFGGETVKNMSIASRMTMTNMAIEMGGKTGIIEPDEKTINYVKEAMEKHGTLREFKPIK 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A F   Y  +  K+EP+ A PH+ DN    RE     I++V+IGSCT G+ ED   
Sbjct: 255 GDEDAEFSEVYEIEADKIEPVFACPHNVDNVKQCREVAGKPIDQVFIGSCTNGRLEDLRM 314

Query: 528 AAKVFLASGG 557
           A  V    GG
Sbjct: 315 AINVIEKHGG 324

[125][TOP]
>UniRef100_A4XJ48 3-isopropylmalate dehydratase large subunit n=1
           Tax=Caldicellulosiruptor saccharolyticus DSM 8903
           RepID=LEUC_CALS8
          Length = 429

 Score =  155 bits (392), Expect = 2e-36
 Identities = 79/190 (41%), Positives = 117/190 (61%), Gaps = 1/190 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  ++FV+ G+   +   KD+IL IIG I V GA YKS
Sbjct: 138 STGIGSTDMACAMATGKCWFKVPEAIKFVLYGKKTGWTSGKDIILHIIGMIGVDGALYKS 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  ++SL+M++R T+ NM +EAG KNG+   D  T +Y++  ++ PY+   +D+ A
Sbjct: 198 MEYTGEGLKSLSMDDRFTIANMAIEAGAKNGIFEVDEKTIEYVKQHSTKPYKIFKADEDA 257

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y  D++K+ P VA PH P+N     E  + + I++V IGSCT G+ ED   AAK+
Sbjct: 258 EYSEVYEIDISKIRPTVAFPHLPENTKTIDEITEKIYIDQVVIGSCTNGRIEDLRIAAKI 317

Query: 540 FLASGGKKVK 569
                G+KVK
Sbjct: 318 L---KGRKVK 324

[126][TOP]
>UniRef100_C0QS35 3-isopropylmalate dehydratase, large subunit n=1 Tax=Persephonella
           marina EX-H1 RepID=C0QS35_PERMH
          Length = 428

 Score =  155 bits (391), Expect = 3e-36
 Identities = 74/188 (39%), Positives = 116/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  ++   G+  LKVP T++F   G+   ++  KD +L +IGEI V GA Y++
Sbjct: 136 STGVGSTDIAYIFATGETWLKVPETMKFTFYGKPQRWVGGKDFVLTVIGEIGVDGALYRA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  +++L++E R+T+ NM +EAGGKN ++  D    ++L+ KT  P   + +D  A
Sbjct: 196 MEYHGEAIQALDVENRLTIANMAIEAGGKNAIMEADEKVLEWLKDKTDRPLRMLKADPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++  EY FD +K+EP+VA P+ P N     E     IN+V+IGSCT G+  D   AA + 
Sbjct: 256 KYCCEYEFDASKIEPVVAAPNLPSNVKPVTEVAGKPINQVFIGSCTNGRMSDLRIAAHIL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[127][TOP]
>UniRef100_C4CHB6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CHB6_9CHLR
          Length = 418

 Score =  155 bits (391), Expect = 3e-36
 Identities = 78/179 (43%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G   ++VPPT++FV +G +P+ +  KDLIL  IG+I V GA Y  
Sbjct: 134 ATGMGSTDIAAAMALGTTWVRVPPTIKFVYNGTLPEGVGGKDLILYTIGQIGVDGALYAV 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L+M+ R+ + NM +EAG K G+   D  T ++L   T  PYE V SD  A
Sbjct: 194 MEFTGEVIDALDMDGRIAMANMAIEAGAKTGIFACDDKTREWLARVTDRPYEPVESDPDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +L    FDV+ L+P+VA PH P N   A E  D+ I++V IGSCT G+  D    AK+
Sbjct: 254 EYLKVIEFDVSNLKPVVALPHLPSNVYPADEVGDMPIHQVVIGSCTNGRISDLREVAKI 312

[128][TOP]
>UniRef100_Q3Z9A7 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides
           ethenogenes 195 RepID=Q3Z9A7_DEHE1
          Length = 417

 Score =  154 bits (390), Expect = 4e-36
 Identities = 77/181 (42%), Positives = 112/181 (61%), Gaps = 1/181 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G++D       GK   +VP T++ V+ G     + AKDLIL +IG I   GATYK+
Sbjct: 132 STGMGSSDIAVAFALGKTWFRVPETIKVVVSGRFKHGIYAKDLILYLIGLIGADGATYKA 191

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG-KTSVPYESVYSDQQ 359
           +EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL        Y+ + +D+ 
Sbjct: 192 LEFSGNVVNNMTIAERLTIANMAVEAGAKVGLFPSDRQTLEYLRSVGREADYQPLAADED 251

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +      D T LEP+VAKPH+ DN A ARE K  K+++V+IG+CTGG+ +D   AA +
Sbjct: 252 AVYERVIEIDATALEPMVAKPHTVDNTATARELKGTKLDQVFIGTCTGGRLDDLAVAAAI 311

Query: 540 F 542
           F
Sbjct: 312 F 312

[129][TOP]
>UniRef100_C7MMM0 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Cryptobacterium curtum DSM 15641 RepID=C7MMM0_CRYCD
          Length = 423

 Score =  154 bits (390), Expect = 4e-36
 Identities = 78/179 (43%), Positives = 105/179 (58%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD G     G+   KVP T+R  ++G +   + AKD IL IIG I V GA Y++
Sbjct: 139 STGMGSTDVGVAFATGRAWFKVPQTIRINLEGSLASTVTAKDAILHIIGRIGVDGALYQA 198

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +E L++E RMT+ NM +EAGGK G+ P D+ T  YL+ +T  PY     D+ A
Sbjct: 199 MEFHGGAIEGLSIEGRMTMANMAIEAGGKAGLFPVDTTTRAYLDARTERPYTVYNPDEGA 258

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +      D   + P VA PH P N     E +DV I++  IGSCT G+ ED  AAA V
Sbjct: 259 VYARTITIDAADIVPTVAFPHLPSNTRPVAEARDVAIDQAVIGSCTNGRIEDMRAAAHV 317

[130][TOP]
>UniRef100_A7VIP8 Putative uncharacterized protein n=1 Tax=Clostridium sp. L2-50
           RepID=A7VIP8_9CLOT
          Length = 441

 Score =  154 bits (390), Expect = 4e-36
 Identities = 79/195 (40%), Positives = 117/195 (60%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F + GE   ++  KD+IL IIG I V GA YKS
Sbjct: 156 STGVGSTDMAAGMVTGKAWFKVPSAIKFNIVGEKAPWVSGKDVILHIIGMIGVDGALYKS 215

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +++L M++R T+ NM +EAG KNG+ P D +T  Y++  ++  Y+   +D  A
Sbjct: 216 MEFVGDGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTEAYMKEHSTKAYKKYEADADA 275

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  EY  D++ L P VA PH P+N     E  D+KI++V IGSCT G+  D   AA + 
Sbjct: 276 VYDEEYTIDLSTLRPTVAFPHLPENTKTIDEVGDIKIDQVVIGSCTNGRISDMRIAADII 335

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 336 KGRQVAPGVRVIVIP 350

[131][TOP]
>UniRef100_A8ABG2 3-isopropylmalate dehydratase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8ABG2_IGNH4
          Length = 429

 Score =  154 bits (390), Expect = 4e-36
 Identities = 77/190 (40%), Positives = 125/190 (65%), Gaps = 2/190 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TDA   +  G++  KVP  L+F + G+  + +++KDLIL+IIG++   GATY S
Sbjct: 134 ATGVGSTDAAIAMMTGRIWFKVPEALKFNLIGKFREGVMSKDLILKIIGDLKEDGATYMS 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKT-SVPY-ESVYSDQ 356
            EFVG  ++ + ++ R+T+ NMVVE G K G++P D    +++EG+   VP  E  + D 
Sbjct: 194 AEFVGDGLKDMRIDSRLTVSNMVVEMGAKVGLMPADEEVMRFVEGRARGVPKPELTFPDP 253

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A +  E+ +D++++EP+VAKP+SP N     E + +++++V+IGSCT G+ ED   AA+
Sbjct: 254 GAHYKDEFTYDLSEIEPMVAKPYSPANSVPVSEVEGIEVDQVFIGSCTNGRLEDVAVAAR 313

Query: 537 VFLASGGKKV 566
           +     GKKV
Sbjct: 314 IL---KGKKV 320

[132][TOP]
>UniRef100_UPI00016C08CB 3-isopropylmalate dehydratase, large subunit n=1 Tax=Epulopiscium
           sp. 'N.t. morphotype B' RepID=UPI00016C08CB
          Length = 421

 Score =  154 bits (389), Expect = 5e-36
 Identities = 80/188 (42%), Positives = 113/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F +  +   Y+  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGKAWFKVPSAIKFNLINQPTKYVSGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L+M+ R T+ NM +EAG KNG+   D +T +YL+G+T   Y    SD  A
Sbjct: 196 MEFVGDGIQHLSMDSRFTMANMAIEAGAKNGIFEVDFITREYLKGRTDREYIVYTSDADA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++K+ P V+ PHSPDN     E  ++KI++V IGSCT G+ ED   A+ + 
Sbjct: 256 IYDEVITIDLSKVRPTVSCPHSPDNTXTLDELPEIKIDQVVIGSCTNGRLEDLRMASDIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[133][TOP]
>UniRef100_Q1Q122 Similar to 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q122_9BACT
          Length = 437

 Score =  154 bits (389), Expect = 5e-36
 Identities = 73/179 (40%), Positives = 109/179 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD       GK+ LKVP +++FV  G+  ++   KD IL  IG+I V GA YK+
Sbjct: 143 STGIGSTDLAACFATGKVWLKVPESIKFVFHGKARNWTSGKDFILYTIGKIGVDGALYKA 202

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G+ +  L M++R T+CNM +EAG K+G+I PD +T  Y+ G+    Y + +SD  +
Sbjct: 203 MEFTGTAISDLPMDDRFTICNMAIEAGAKSGIIAPDKITENYVAGRVKREYVAYHSDPDS 262

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y F+  ++ P VA P  P+N     +   +KI++V IGSCT G+  D   AAK+
Sbjct: 263 HYSKVYEFNAEEIVPQVALPSLPENTKSVYDVCGIKIDQVVIGSCTNGRISDLRIAAKI 321

[134][TOP]
>UniRef100_A6UPF6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           vannielii SB RepID=A6UPF6_METVS
          Length = 424

 Score =  154 bits (389), Expect = 5e-36
 Identities = 77/190 (40%), Positives = 114/190 (60%), Gaps = 5/190 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   G+L  KVP T+ F + G +   +++KD+IL IIG +   GATYK+
Sbjct: 135 ATGIGSTDMAAVFATGELWFKVPETMYFNISGHLKPEVMSKDIILSIIGMVGADGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL-----EGKTSVPYESVY 347
            +F G TV+ + +  RMT+ NM +E GGK G+I PD  T +Y+     +  T+ P++ + 
Sbjct: 195 AQFAGETVKEMTIASRMTMSNMAIEMGGKAGLIEPDRKTVEYVKTAMEKNNTARPFDIII 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 527
            D+ A +  ++  +V  LEP++A PH+ DN    RE     I++V+IGSCT G+ ED  A
Sbjct: 255 GDKNAEYEEKFEIEVNDLEPVMACPHNVDNVKTVREVSGTPIDQVFIGSCTNGRIEDLRA 314

Query: 528 AAKVFLASGG 557
           A  V    GG
Sbjct: 315 ALNVIEKHGG 324

[135][TOP]
>UniRef100_Q3AD33 3-isopropylmalate dehydratase, large subunit family protein n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AD33_CARHZ
          Length = 417

 Score =  154 bits (388), Expect = 6e-36
 Identities = 75/194 (38%), Positives = 118/194 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    + +GKL  KVP T++FV+ G++P  + AKDLIL +IG++T  GATY +
Sbjct: 133 ATGVGSTDLAAAIISGKLWFKVPETIKFVLKGKLPKGVFAKDLILYLIGDVTADGATYMA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            E+ G  +  L+M+ R T+ NM +E G K G++  D  T+ +++      +  V++D  A
Sbjct: 193 AEYTGEAISDLSMDGRFTIANMAIEMGAKAGLMEADEKTFAFVKEHGGKDFTPVFADPDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +     +DV++LEP+VAKPH+ DN A   E     I++  +G+CT G+ ED   AAK+ 
Sbjct: 253 VYAKVLEYDVSELEPMVAKPHTVDNTARVTEVAGTPIHQAVLGTCTNGRLEDLRIAAKIL 312

Query: 543 LASGGKKVKVPTFL 584
               G+K+   T L
Sbjct: 313 ---EGRKIHPRTRL 323

[136][TOP]
>UniRef100_A0LMK9 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMK9_SYNFM
          Length = 419

 Score =  154 bits (388), Expect = 6e-36
 Identities = 80/188 (42%), Positives = 115/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G++  KVP +++FV  G++  ++  KDLIL  IG+I V GA Y++
Sbjct: 136 ATGVGSTDLAAAMITGRVWFKVPFSMKFVYRGKLGPWVGGKDLILYTIGQIGVDGARYRA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  ++ L M +R ++CNM +EAG K G+I PD VT +Y++G+    YE   SD  A
Sbjct: 196 MEFTGEVIDRLPMSDRFSMCNMAIEAGAKAGIIAPDPVTEEYVKGRAKRSYEFYRSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            F S + +DV+  EP+VA PHSP N           I++V IGSCT G+ ED   AA + 
Sbjct: 256 AFESVHEWDVSAFEPMVALPHSPANVRPVSRIPRTVIDQVVIGSCTNGRYEDLETAAAIL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[137][TOP]
>UniRef100_C0CLF7 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CLF7_9FIRM
          Length = 422

 Score =  154 bits (388), Expect = 6e-36
 Identities = 78/190 (41%), Positives = 118/190 (62%), Gaps = 1/190 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVPP ++F + G+   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGKAWFKVPPAIKFHLTGKPSKWVSGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D +   Y+   +   ++   +D+ A
Sbjct: 196 MEFVGDGIQHLSMDDRFTIANMAIEAGGKNGIFPVDDLAVAYMREHSKREFKIYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +  EY  D+++L+P +A PH P+N R +     DV I++  IGSCT G+ ED   AA++
Sbjct: 256 VYEEEYTIDLSQLKPTIAFPHLPENTRTIDEITADVVIDQSVIGSCTNGRMEDLRIAAEI 315

Query: 540 FLASGGKKVK 569
                G+KVK
Sbjct: 316 L---KGRKVK 322

[138][TOP]
>UniRef100_B9D2G7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           rectus RM3267 RepID=B9D2G7_WOLRE
          Length = 424

 Score =  154 bits (388), Expect = 6e-36
 Identities = 81/197 (41%), Positives = 123/197 (62%), Gaps = 3/197 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  + +  GK   KVPPT++ +  G++  ++  KDLIL+II  I V GA YK+
Sbjct: 138 ATGMGSTDLAYAMITGKNWFKVPPTIKVIFRGKLDRHVYGKDLILEIIRHIGVDGALYKA 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESV-YSDQQ 359
           +EF G T+E+L+M+ R ++CNM +EAGGK+G+I  D  T ++L+GK       + YSD+ 
Sbjct: 198 LEFTGETIENLDMDGRFSMCNMAIEAGGKSGIIAVDETTKEFLKGKNLRAEPKLHYSDEG 257

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRVYIGSCTGGKTEDFMAAA 533
           A +    + DV+KL+P++A P  P N    RE    D+ I++ +IGSCT G+  D   AA
Sbjct: 258 ANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVKDDIAIDQAFIGSCTNGRLSDLRIAA 317

Query: 534 KVFLASGGKKVKVPTFL 584
           ++     G+KV   T L
Sbjct: 318 EIL---KGRKVARKTRL 331

[139][TOP]
>UniRef100_A6Q5L6 3-isopropylmalate dehydratase large subunit n=1 Tax=Nitratiruptor
           sp. SB155-2 RepID=LEUC_NITSB
          Length = 421

 Score =  154 bits (388), Expect = 6e-36
 Identities = 80/191 (41%), Positives = 121/191 (63%), Gaps = 3/191 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  + +  GK   KVPP+++ +  G++ +++  KDLIL++I  I V GA YK+
Sbjct: 135 ATGMGSTDLAYGMITGKNWFKVPPSIKVIYTGKLGEHVYGKDLILELIRRIGVDGALYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESV-YSDQQ 359
           +EF G T+E+L+M+ R +LCNM +EAG KNG+I  D VT  +L  K       + YSD+ 
Sbjct: 195 LEFTGDTIENLDMDGRFSLCNMAIEAGAKNGIIAVDEVTKAFLADKPLAREPKIHYSDED 254

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINRVYIGSCTGGKTEDFMAAA 533
           A +      DV  LEP++A PH P N R ++   K D+K+++V+IGSCT G+  D   AA
Sbjct: 255 AEYEQVIEIDVNNLEPVIAFPHLPSNGRPISEAAKMDLKVDQVFIGSCTNGRLSDIAIAA 314

Query: 534 KVFLASGGKKV 566
           ++     G+KV
Sbjct: 315 EIL---KGRKV 322

[140][TOP]
>UniRef100_C6RH21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           showae RM3277 RepID=C6RH21_9PROT
          Length = 424

 Score =  153 bits (387), Expect = 8e-36
 Identities = 81/197 (41%), Positives = 122/197 (61%), Gaps = 3/197 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  + +  GK   KVPPT++ +  G++  ++  KDLIL+II  I V GA YK+
Sbjct: 138 ATGMGSTDLAYAMITGKNWFKVPPTIKVIFRGKLDRHVYGKDLILEIIRRIGVDGALYKA 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESV-YSDQQ 359
           +EF G T+E+L+M+ R ++CNM +EAGGK+G+I  D  T ++L+GK       + YSD+ 
Sbjct: 198 LEFTGETIENLDMDGRFSMCNMAIEAGGKSGIIAVDETTKEFLKGKNLRAEPKLHYSDEG 257

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRVYIGSCTGGKTEDFMAAA 533
           A +      DV+KL+P++A P  P N    RE    D+ I++ +IGSCT G+  D   AA
Sbjct: 258 ANYEQILEIDVSKLDPVIAYPFLPSNGKSVREAVRDDIAIDQAFIGSCTNGRLSDLRIAA 317

Query: 534 KVFLASGGKKVKVPTFL 584
           ++     G+KV   T L
Sbjct: 318 EIL---KGRKVARKTRL 331

[141][TOP]
>UniRef100_B1QZX5 3-isopropylmalate dehydratase, large subunit n=2 Tax=Clostridium
           butyricum RepID=B1QZX5_CLOBU
          Length = 419

 Score =  153 bits (387), Expect = 8e-36
 Identities = 80/188 (42%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  L+FV+  +   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGKCWFKVPSALKFVLKNKPAKWISGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL+      ++   +D+ A
Sbjct: 196 MEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDEKTEEYLKDHAKREWKKYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++   Y  D++ L P V+ PH PDN        DVKI++V IGSCT G+  D   A  + 
Sbjct: 256 QYDEVYEIDLSTLRPTVSFPHLPDNTRTIDNTGDVKIDQVVIGSCTNGRISDLRVARDIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[142][TOP]
>UniRef100_B5IEF0 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IEF0_9EURY
          Length = 418

 Score =  153 bits (387), Expect = 8e-36
 Identities = 69/179 (38%), Positives = 112/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A GIG ++   +   GK+ L+VP +   +++GEMP  + AKDL L IIG+IT +GA YK+
Sbjct: 134 AAGIGRSEVAAIWATGKIWLRVPESYEIIVEGEMPKGVFAKDLALHIIGDITASGAVYKA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G T+ ++++  R+ L NM  E G KNG+I  D  T  YL+ +   PYE ++ D+ A
Sbjct: 194 VEFKGETIRNMSIASRIVLTNMSAEMGAKNGIIEADEKTEAYLKTRARAPYEIMHPDEDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y +D + L P +A PH+ DN     + + +++N+V++G+CT G+ ED   AA++
Sbjct: 254 EYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGIEVNQVFLGTCTNGRVEDLEVAARI 312

[143][TOP]
>UniRef100_B9MLV4 3-isopropylmalate dehydratase large subunit n=1 Tax=Anaerocellum
           thermophilum DSM 6725 RepID=LEUC_ANATD
          Length = 429

 Score =  153 bits (387), Expect = 8e-36
 Identities = 77/190 (40%), Positives = 117/190 (61%), Gaps = 1/190 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  ++F++ G+   +   KD+IL IIG I V GA YKS
Sbjct: 138 STGIGSTDMACAMATGKCWFKVPEAIKFILYGKKTGWTSGKDIILHIIGMIGVDGALYKS 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  ++SL+M++R T+ NM +EAG KNG+   D  T +Y++  ++ PY+   +D+ A
Sbjct: 198 MEYTGEGLKSLSMDDRFTIANMAIEAGAKNGIFEVDEKTIEYVKQHSTKPYKIFKADEDA 257

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYIGSCTGGKTEDFMAAAKV 539
            +   +  D++K+ P VA PH P+N     E  + + I++V IGSCT G+ ED   AAK+
Sbjct: 258 EYSQVFEIDISKIRPTVAFPHLPENTKTIDEITEKIYIDQVVIGSCTNGRIEDLRIAAKI 317

Query: 540 FLASGGKKVK 569
                G+KVK
Sbjct: 318 L---KGRKVK 324

[144][TOP]
>UniRef100_O27439 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanothermobacter thermautotrophicus str. Delta H
           RepID=LEUC1_METTH
          Length = 419

 Score =  153 bits (387), Expect = 8e-36
 Identities = 76/179 (42%), Positives = 109/179 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   GKL  +VP TLRF + G++ +++ AKD+IL IIG +   GATY +
Sbjct: 135 ATGIGSTDMAMVFATGKLWFRVPETLRFDVRGKLREHVYAKDVILNIIGRVGADGATYMA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            EF G TV  +++ +RM L NM +E GGK G++ PD  T  Y+  ++  P+    +D  A
Sbjct: 195 CEFAGETVAEMSVSDRMVLSNMAIEMGGKTGIVEPDEKTLNYVRRRSGKPWRVFKTDPDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
             LS    DV+ LEP VA PH+ DN     E +  +I++V++GSCT G+  D   AA +
Sbjct: 255 PSLSVMEVDVSDLEPQVACPHNVDNVKPVTEVEGTEIDQVFLGSCTNGRLSDLRDAAAI 313

[145][TOP]
>UniRef100_UPI0001966774 hypothetical protein METSMIF1_00490 n=1 Tax=Methanobrevibacter
           smithii DSM 2374 RepID=UPI0001966774
          Length = 415

 Score =  153 bits (386), Expect = 1e-35
 Identities = 82/188 (43%), Positives = 116/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD   V   G L  KVP T RF + GE+ + + AKD+IL IIG++ V G+TYK+
Sbjct: 135 STGIGSTDMAMVFAEGNLWFKVPETNRFEITGELKNNVYAKDVILNIIGQVGVDGSTYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            EF G TV ++++ +RM L NM +E GGK G++ PD  T  Y+E +++  Y+   +D  A
Sbjct: 195 CEFAGETVSNMSISDRMVLTNMAIEMGGKTGLVEPDKKTIDYVESRSNKAYKVFKTDLDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
             L+    DV+ LEP VA PH  DN     E  D +I++V++GSCT G+  D   AAK+ 
Sbjct: 255 PSLNIIDIDVSDLEPQVACPHHVDNVKAVSEV-DQEIDQVFLGSCTNGRISDLRDAAKIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[146][TOP]
>UniRef100_A5FS15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FS15_DEHSB
          Length = 431

 Score =  153 bits (386), Expect = 1e-35
 Identities = 77/181 (42%), Positives = 110/181 (60%), Gaps = 1/181 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G++D       GK   +VP T++ V+ G     L AKDLIL +IG I   GATYK+
Sbjct: 146 ATGMGSSDIAVAFALGKTWFRVPETIKVVVSGRFKHGLYAKDLILHLIGLIGADGATYKA 205

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG-KTSVPYESVYSDQQ 359
           +EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL        Y+ + +D  
Sbjct: 206 LEFSGNVVNNMTVAERLTIANMAVEAGAKVGLFPSDRQTLEYLRSVGREADYQPLAADAD 265

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +      D T LEP ++KPH+ DN A ARE K  K+++V+IG+CTGG+ +D   AA +
Sbjct: 266 AVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFIGTCTGGRLDDLAVAAAI 325

Query: 540 F 542
           F
Sbjct: 326 F 326

[147][TOP]
>UniRef100_C8SBC1 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SBC1_FERPL
          Length = 427

 Score =  153 bits (386), Expect = 1e-35
 Identities = 78/189 (41%), Positives = 116/189 (61%), Gaps = 1/189 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  GK   +VP + + V++GE    + AKDLIL IIGE+ V GATYK+
Sbjct: 142 ATGMGSTDIAIAMALGKNWFRVPESFKIVVEGEFQKGVFAKDLILWIIGELGVDGATYKA 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL-EGKTSVPYESVYSDQQ 359
           +EF G T++ L+M+ R+T+ NM +E G K G+   D VT K+L E      +  +  D+ 
Sbjct: 202 LEFHGETIDKLDMDSRLTIANMAIECGAKAGLFKSDEVTKKFLMERGRGDKFREIKPDED 261

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +  E  FDV+ L P+VAKPH  DN A   E + VK+++V++G+CT G+  D    A++
Sbjct: 262 AEYEKEMYFDVSDLTPIVAKPHQVDNIARIDEVEGVKVDQVFVGTCTNGRLSDLEVVARI 321

Query: 540 FLASGGKKV 566
                G+KV
Sbjct: 322 L---KGRKV 327

[148][TOP]
>UniRef100_A6LPX4 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           beijerinckii NCIMB 8052 RepID=LEUC_CLOB8
          Length = 419

 Score =  153 bits (386), Expect = 1e-35
 Identities = 80/189 (42%), Positives = 113/189 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  L+FV+  +   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGKCWFKVPSALKFVLKNKPAKWISGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D  T +YL+   S  ++   +D+ A
Sbjct: 196 MEFVGDGLQYLSMDDRFTMANMAIEAGGKNGIFPVDDKTEEYLKDHASREWKVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   +  D+++L P V+ PH PDN        DV I++V IGSCT G+  D   A  + 
Sbjct: 256 EYDKVFEIDLSELRPTVSFPHLPDNTRTIDNTGDVAIDQVVIGSCTNGRISDLRMARDIL 315

Query: 543 LASGGKKVK 569
               GKKVK
Sbjct: 316 ---KGKKVK 321

[149][TOP]
>UniRef100_Q97EE0 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           acetobutylicum RepID=LEUC_CLOAB
          Length = 422

 Score =  153 bits (386), Expect = 1e-35
 Identities = 75/189 (39%), Positives = 115/189 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++FV+ G+   ++  KD+IL IIG I V GA YKS
Sbjct: 138 STGVGSTDMAVGMATGKAWFKVPEAIKFVLKGKPAKWVSGKDIILHIIGMIGVDGALYKS 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  +E L+M++R T+ NM +EAG KNG+ P D  T +Y++G++    +   +D+ A
Sbjct: 198 MEYTGDGLEYLSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYMKGRSDRELKKFDADEDA 257

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++ L+P VA PH P+N     +  +V +++V IGSCT G+ ED   AA + 
Sbjct: 258 EYSRVIEIDLSTLKPTVAFPHLPENTKTIDQVGEVNVDQVVIGSCTNGRMEDLRIAASIL 317

Query: 543 LASGGKKVK 569
               GKK+K
Sbjct: 318 ---KGKKIK 323

[150][TOP]
>UniRef100_B9E370 Putative uncharacterized protein n=1 Tax=Clostridium kluyveri NBRC
           12016 RepID=B9E370_CLOK1
          Length = 426

 Score =  152 bits (385), Expect = 1e-35
 Identities = 76/188 (40%), Positives = 115/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  ++FV++G++  ++  KD+IL IIG I V GA Y S
Sbjct: 142 STGVGSTDMAAGMATGEAWFKVPEAIKFVLNGKLSPWVSGKDIILHIIGMIGVDGALYNS 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V  L+M++R T+ NM +EAG KNG+ P D  T +Y++  ++  Y    +D+ A
Sbjct: 202 MEFTGEGVGELSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYVKEHSNRSYTVYEADEDA 261

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++     D++K+ P VA PH P+N     E  ++KI++V IGSCT G+  D   AAKV 
Sbjct: 262 EYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEIKIDQVVIGSCTNGRIGDLRVAAKVL 321

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 322 ---KGRKV 326

[151][TOP]
>UniRef100_A6DDD6 3-ISOPROPYLMALATE DEHYDRATASE, LARGE SUBUNIT n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDD6_9PROT
          Length = 425

 Score =  152 bits (385), Expect = 1e-35
 Identities = 84/195 (43%), Positives = 119/195 (61%), Gaps = 7/195 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  F +  GK   KVP +++ V  G+  +++  KDLIL++I  I V GA YK+
Sbjct: 135 STGMGSTDIAFSMITGKSWFKVPESIKVVFTGQRGEHVYGKDLILELIRRIGVDGALYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG-KTSVPYESV----Y 347
           +EF G T+E+L M++RM+LCNMV+EAG KNG+I  D +T  +LE  K   P  S     Y
Sbjct: 195 LEFTGDTIENLPMDDRMSLCNMVIEAGAKNGIIAYDKITESFLEEVKKHNPLRSTPKIHY 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRVYIGSCTGGKTEDF 521
           SD  A+++     DV  LEP+VA P+ P N     E    D++I++VYIGSCT G   D 
Sbjct: 255 SDPDAKYVKIIEIDVDNLEPMVAYPYLPSNGKPISEAVKDDIEIHQVYIGSCTNGTLSDL 314

Query: 522 MAAAKVFLASGGKKV 566
             AA +     GK+V
Sbjct: 315 RTAANIL---KGKRV 326

[152][TOP]
>UniRef100_A5MZ75 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           kluyveri DSM 555 RepID=LEUC_CLOK5
          Length = 420

 Score =  152 bits (385), Expect = 1e-35
 Identities = 76/188 (40%), Positives = 115/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  ++FV++G++  ++  KD+IL IIG I V GA Y S
Sbjct: 136 STGVGSTDMAAGMATGEAWFKVPEAIKFVLNGKLSPWVSGKDIILHIIGMIGVDGALYNS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V  L+M++R T+ NM +EAG KNG+ P D  T +Y++  ++  Y    +D+ A
Sbjct: 196 MEFTGEGVGELSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYVKEHSNRSYTVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++     D++K+ P VA PH P+N     E  ++KI++V IGSCT G+  D   AAKV 
Sbjct: 256 EYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEIKIDQVVIGSCTNGRIGDLRVAAKVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[153][TOP]
>UniRef100_Q3Z894 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z894_DEHE1
          Length = 416

 Score =  152 bits (384), Expect = 2e-35
 Identities = 73/178 (41%), Positives = 110/178 (61%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD    +  G++ +KVPPT++F   G++P ++  KDLIL  IG+I V GA Y +M
Sbjct: 134 TGMGSTDIAAAMATGEVWMKVPPTIKFNYSGKLPKWIGGKDLILFTIGQIGVDGALYSAM 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
            F G  +++L+ME R T+ NM +EAGGK G+   D  T +Y+  +    Y    +D  A 
Sbjct: 194 YFCGEAIDALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQYTVYDNDADAS 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           +   Y FD++KLEP V+ PHSP N     +   +K+++V IGSCT G+ ED   +AK+
Sbjct: 254 YAKTYNFDISKLEPQVSLPHSPANARPISQIGKIKVDQVIIGSCTNGRLEDLAISAKL 311

[154][TOP]
>UniRef100_C6PQI2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           carboxidivorans P7 RepID=C6PQI2_9CLOT
          Length = 421

 Score =  152 bits (384), Expect = 2e-35
 Identities = 75/180 (41%), Positives = 112/180 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD G  +  G+   KVP  ++FV+ G+M  ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMGAGMATGEAWFKVPEAIKFVLKGKMAPWVSGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  +++L+M++R T+ NM +EAG KNG+   D  T +Y++  ++  Y    +D+ A
Sbjct: 196 MEYTGEGLKNLSMDDRFTMANMAIEAGAKNGIFEVDDKTIEYVKEHSNREYTVYTADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++ + P VA PH P+N     E  +V I++  IGSCT G+ ED  AAAKVF
Sbjct: 256 EYSKVIEIDLSSIRPTVAFPHLPENTRTIDEVGEVFIDQAVIGSCTNGRIEDLRAAAKVF 315

[155][TOP]
>UniRef100_B0A9M7 Putative uncharacterized protein n=1 Tax=Clostridium bartlettii DSM
           16795 RepID=B0A9M7_9CLOT
          Length = 429

 Score =  152 bits (384), Expect = 2e-35
 Identities = 84/193 (43%), Positives = 119/193 (61%), Gaps = 5/193 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  ++FV+  +   ++  KD+IL IIGEI V GA Y S
Sbjct: 136 STGIGSTDMAAGMATGKAWFKVPGAIKFVLKNKPAKWISGKDIILHIIGEIGVDGARYMS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG---KTSVPYESVY-S 350
           MEF G  V+ L+M++R T+CNM +EAG KNG+ P D  T +Y+E    KT     +VY +
Sbjct: 196 MEFAGDGVQYLSMDDRFTICNMAIEAGAKNGIFPVDEKTKEYMEAHPCKTIEKNPTVYEA 255

Query: 351 DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE-CKDVKINRVYIGSCTGGKTEDFMA 527
           D+ A +      D+++L+P VA PH P+N     E  +D+KI++V IGSCT G+ ED   
Sbjct: 256 DEDAEYDRVIEIDLSELKPTVAFPHLPENTKTTDEITEDIKIDQVVIGSCTNGRIEDMRI 315

Query: 528 AAKVFLASGGKKV 566
           AA++     GKKV
Sbjct: 316 AAEIM---RGKKV 325

[156][TOP]
>UniRef100_A8RZ58 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RZ58_9CLOT
          Length = 420

 Score =  152 bits (384), Expect = 2e-35
 Identities = 75/195 (38%), Positives = 119/195 (61%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F + G+   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMVTGKAWFKVPSAIKFQLVGKPAKWVSGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  + +L+M++R T+CNM +EAGGKNG+ P D +  +Y++  +   +    +D+ A
Sbjct: 196 MEFVGEGIRNLSMDDRFTICNMAIEAGGKNGIFPVDELAVEYMKEHSKREFTVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  D+++L+P V+ PH P N     +  +VK+++  IGSCT G+ ED   AA+V 
Sbjct: 256 EYDETYVIDLSELKPTVSFPHLPSNTRTIDQVGEVKVDQAVIGSCTNGRIEDMRIAAEVL 315

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 316 KGRKIAKGVRCIVIP 330

[157][TOP]
>UniRef100_A8CU07 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           VS RepID=A8CU07_9CHLR
          Length = 417

 Score =  152 bits (384), Expect = 2e-35
 Identities = 76/181 (41%), Positives = 112/181 (61%), Gaps = 1/181 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G++D       GK   +VP T++ V++G     + AKDLIL +IG I   GATYK+
Sbjct: 132 STGMGSSDIAVAFALGKTWFRVPETIKVVVNGRFKHGIYAKDLILHLIGLIGADGATYKA 191

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG-KTSVPYESVYSDQQ 359
           +EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL        Y+ + +D+ 
Sbjct: 192 LEFSGNVVNNMMIAERLTIANMAVEAGAKVGLFPSDRQTLEYLRSVGREADYQPLAADEN 251

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +      D T LEP V+KPH+ DN A ARE K  K+++V+IG+CTGG+ +D   AA +
Sbjct: 252 AVYERVIEIDATALEPTVSKPHTVDNTATARELKGTKLDQVFIGTCTGGRLDDLAVAAAI 311

Query: 540 F 542
           F
Sbjct: 312 F 312

[158][TOP]
>UniRef100_A2SR25 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanocorpusculum labreanum Z RepID=A2SR25_METLZ
          Length = 392

 Score =  152 bits (384), Expect = 2e-35
 Identities = 73/179 (40%), Positives = 112/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD  +VL  G+L  +VP T+R   +G+  + +  KDLIL + G+I   GATY++
Sbjct: 109 STGIGSTDMAYVLKFGELYFRVPETIRINANGKFQNRVGPKDLILTLAGDIGADGATYRA 168

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G+    +++  RMT  NM +E G K G++PPD  T++Y+ G+T V   S+ SD+ A
Sbjct: 169 LEFCGNAFSEMDIPGRMTCANMAIEMGAKAGIVPPDEKTWEYMRGRTEVTPFSLASDEDA 228

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            F     +D+ K+ P +A PH+ DN     E     +++V+IGSCT G+ EDF  AA+V
Sbjct: 229 VFFETRNYDIAKINPKIAVPHNVDNVVDVTEVAGKPVDQVFIGSCTNGRYEDFAEAAEV 287

[159][TOP]
>UniRef100_C0EDN6 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EDN6_9CLOT
          Length = 421

 Score =  152 bits (383), Expect = 2e-35
 Identities = 75/179 (41%), Positives = 111/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  +RF + G+   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGEAWFKVPSAIRFNLTGKPRKWVSGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L M++R+ + NM +EAGGKNG+   D VT  Y++ K + PY +   D  A
Sbjct: 196 MEFGGEGLKNLTMDDRLCMANMAIEAGGKNGIFEVDEVTIAYMKDKVNRPYTAYAPDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            + + Y  D+++++  V+ PH PDN     E  DVKI++V IGSCT G+  D   AAK+
Sbjct: 256 EYDAVYDIDLSQIKSTVSFPHLPDNTRTIDEVGDVKIDQVVIGSCTNGRLSDIAVAAKI 314

[160][TOP]
>UniRef100_A8CP51 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. VS RepID=A8CP51_9CHLR
          Length = 416

 Score =  152 bits (383), Expect = 2e-35
 Identities = 73/178 (41%), Positives = 110/178 (61%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD    +  G++ +KVPPT++F   G++P ++  KDLIL  IG+I V GA Y +M
Sbjct: 134 TGMGSTDIAAAMATGEVWMKVPPTIKFNYTGKLPKWIGGKDLILFTIGQIGVDGALYSAM 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
            F G  +++L+ME R T+ NM +EAGGK G+   D  T +Y+  +    Y    +D  A 
Sbjct: 194 YFCGEAIDALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQYTVYDNDADAS 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           +   Y FD++KLEP V+ PHSP N     +   +K+++V IGSCT G+ ED   +AK+
Sbjct: 254 YAKTYNFDISKLEPQVSLPHSPANARPISQIGKIKVDQVIIGSCTNGRLEDLAISAKL 311

[161][TOP]
>UniRef100_B5IER5 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IER5_9EURY
          Length = 418

 Score =  152 bits (383), Expect = 2e-35
 Identities = 70/188 (37%), Positives = 115/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A GIG ++   +   GK+ L+VP +   +++G++P  + AKDL L I+G++T +GA YK+
Sbjct: 134 AAGIGRSEVAAIWATGKIWLRVPESYEIIVNGKLPKGVFAKDLALHIVGDVTASGAVYKA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G T++ + +  RM L NM  E G KNG+I  D  T  YL+ +   PYE ++ D+ A
Sbjct: 194 VEFKGETIKDMTIASRMVLTNMSAEMGAKNGIIEADEKTEAYLKTRARAPYEIMHPDEDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y +D + L P +A PH+ DN     + + +++N+V++G+CT G+ ED   AA++ 
Sbjct: 254 EYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGIEVNQVFLGTCTNGRVEDLEIAARIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[162][TOP]
>UniRef100_Q18AJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile 630 RepID=LEUC_CLOD6
          Length = 425

 Score =  152 bits (383), Expect = 2e-35
 Identities = 83/193 (43%), Positives = 116/193 (60%), Gaps = 5/193 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD G  +  GK   KVP  ++FV+  +   ++  KD+IL IIGEI V GA YKS
Sbjct: 136 STGVGSTDMGAGMATGKCWFKVPGAIKFVLKNKPNKWISGKDIILHIIGEIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG---KTSVPYESVY-S 350
           MEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+      T     ++Y +
Sbjct: 196 MEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYINSHKCSTMTKDVNIYEA 255

Query: 351 DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFMA 527
           D+ A +   Y  D+ KL+  VA PH P+N     E  KD+KI++V IGSCT G+  D   
Sbjct: 256 DEDAVYDEVYEIDLAKLKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLEV 315

Query: 528 AAKVFLASGGKKV 566
            A++     GKKV
Sbjct: 316 VAEIM---KGKKV 325

[163][TOP]
>UniRef100_Q3ZZK0 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           CBDB1 RepID=Q3ZZK0_DEHSC
          Length = 417

 Score =  151 bits (382), Expect = 3e-35
 Identities = 77/181 (42%), Positives = 110/181 (60%), Gaps = 1/181 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G++D       GK   +VP T++ V+ G     L AKDLIL +IG I   GATYK+
Sbjct: 132 ATGMGSSDIAVAFALGKTWFRVPETIKVVVSGRFKHGLYAKDLILHLIGLIGADGATYKA 191

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL-EGKTSVPYESVYSDQQ 359
           +EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL        Y+ + +D  
Sbjct: 192 LEFSGNVVNNMTVAERLTIANMAVEAGAKVGLFPSDRQTLEYLCSVGREADYQPLAADVD 251

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +      D T LEP ++KPH+ DN A ARE K  K+++V+IG+CTGG+ +D   AA +
Sbjct: 252 AVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFIGTCTGGRLDDLAVAAAI 311

Query: 540 F 542
           F
Sbjct: 312 F 312

[164][TOP]
>UniRef100_C9KJM7 3-isopropylmalate dehydratase, large subunit n=2 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KJM7_9FIRM
          Length = 420

 Score =  151 bits (382), Expect = 3e-35
 Identities = 74/180 (41%), Positives = 113/180 (62%), Gaps = 1/180 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD G  +  GK   KVP  ++  + GE    +  KD+IL +IG I V GA YKS
Sbjct: 135 STGVGSTDLGAAMATGKAWFKVPEAIKVNLTGEKSADITGKDVILTLIGMIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V++L M +R+T+ NM +EAGGK G+ P D +T  Y++ + + PYE V +D  A
Sbjct: 195 LEFAGPGVKALTMTDRLTISNMAIEAGGKAGIFPFDEITKAYVDARVTKPYEPVAADDDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYIGSCTGGKTEDFMAAAKV 539
            +  E   ++++L+P+VA PH P N     + K+ ++I++V IGSCT G+ ED   AA +
Sbjct: 255 EYCREVDINLSELKPVVAFPHLPGNTKRVEDIKEPIEIDQVIIGSCTNGRLEDMEIAASI 314

[165][TOP]
>UniRef100_C1I927 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium sp.
           7_2_43FAA RepID=C1I927_9CLOT
          Length = 424

 Score =  151 bits (382), Expect = 3e-35
 Identities = 78/189 (41%), Positives = 113/189 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  ++FV+  +   ++  KD+IL IIG I V GA Y+S
Sbjct: 136 STGIGSTDMAAGMATGKCWFKVPSAIKFVLKNKPSKWVSGKDVILHIIGMIGVDGALYRS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG+ ++ L++++R T+ NM +EAGGKNG+ P D VT +YL       ++   +D+ A
Sbjct: 196 MEFVGNGLKYLSIDDRFTMANMAIEAGGKNGIFPVDDVTIRYLVDHAQREWKVYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  D++KL P VA PH PDN     E  +V +++V IGSCT G+  D   A  + 
Sbjct: 256 EYDEVYEIDLSKLRPTVAFPHLPDNTRTIDEVGEVAVDQVVIGSCTNGRISDLRVARDIL 315

Query: 543 LASGGKKVK 569
                KKVK
Sbjct: 316 ---KNKKVK 321

[166][TOP]
>UniRef100_C0R088 3-isopropylmalate dehydratase large subunit n=1 Tax=Brachyspira
           hyodysenteriae WA1 RepID=C0R088_BRAHW
          Length = 415

 Score =  150 bits (380), Expect = 5e-35
 Identities = 78/188 (41%), Positives = 112/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G++  KVP  ++F + G++   +  KD+IL IIG I V GA YKS
Sbjct: 134 STGVGSTDMAAAMATGQVWFKVPSAIKFNLKGKLKPNVSGKDVILHIIGMIGVDGALYKS 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V SL M++R  + NM +EAG KNG+   D  T +YL+      Y    +D  A
Sbjct: 194 MEFRGEGVSSLTMDDRACIANMAIEAGAKNGIFEVDDQTIEYLKDIVKRDYTVFKADDDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  EY  D++ +EP VA PH P+N   A+E K++K+++V IGSCT G+  D   AA + 
Sbjct: 254 VYDKEYDIDLSLIEPTVACPHLPENTKEAKELKNIKVDQVVIGSCTNGRLSDMATAANIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[167][TOP]
>UniRef100_C0UYG1 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermobaculum
           terrenum ATCC BAA-798 RepID=C0UYG1_9BACT
          Length = 380

 Score =  150 bits (380), Expect = 5e-35
 Identities = 77/191 (40%), Positives = 117/191 (61%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD    L  GK  L+VP T+RF + GE+  ++ AKDL L ++G I V GATY ++
Sbjct: 131 TGMGSTDIAVALATGKTWLRVPETIRFEVKGELGHHVYAKDLALAMVGTIGVDGATYMAV 190

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           E+ G  V  +++ ERMTL NM VE GGK G++ PD    +YL G+   PYE + + +   
Sbjct: 191 EYGGPAVRRMSISERMTLANMAVEMGGKTGLVEPDDTVDEYLRGRARDPYERI-TPRDPV 249

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           +      D + +EP+VA P  P++ A A E + VKI++V+IG+CT G+ +D   AA++  
Sbjct: 250 YSRVVEIDASSIEPMVAVPPDPEHLAPAAEMRKVKIDQVFIGTCTNGRLDDIEIAARIL- 308

Query: 546 ASGGKKVKVPT 578
              G+K+   T
Sbjct: 309 --KGRKIHPST 317

[168][TOP]
>UniRef100_C0D3T2 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0D3T2_9CLOT
          Length = 446

 Score =  150 bits (380), Expect = 5e-35
 Identities = 77/188 (40%), Positives = 114/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++F + G+   ++  KD+IL IIG I V GA YKS
Sbjct: 162 STGVGSTDMAAAMVTGKAWFKVPSAIKFELVGKPGKWVSGKDVILHIIGMIGVDGALYKS 221

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V++L M++R T+CNM +EAGGKNG+ P D  T  YL+  +   ++   +D  A
Sbjct: 222 MEFTGEGVKNLTMDDRFTICNMAIEAGGKNGIFPVDEQTVAYLKEHSKRDFKVYEADPDA 281

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + + Y  D+++L+P V+ PH P N        DVKI++  IGSCT G+ +D   AA++ 
Sbjct: 282 EYDATYVIDLSELKPTVSFPHLPSNTRTIDNVGDVKIDQSVIGSCTNGRIDDMRVAAEIL 341

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 342 ---KGRKV 346

[169][TOP]
>UniRef100_Q0W0U0 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W0U0_UNCMA
          Length = 418

 Score =  150 bits (380), Expect = 5e-35
 Identities = 79/194 (40%), Positives = 120/194 (61%), Gaps = 1/194 (0%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD G ++  G   L+VP   +F ++GE+P Y+ +KD+ L I+ EIT  GATY SM
Sbjct: 135 TGMGSTDVGAIMAYGTTWLRVPEAFKFDINGELPKYVTSKDVFLHIVREITADGATYMSM 194

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL-EGKTSVPYESVYSDQQA 362
           EF+G TV+++++E R+ + NM +EAGGK G+   D    ++L +      Y+ + +D  A
Sbjct: 195 EFMGDTVKNMSVESRLVMSNMAIEAGGKVGLCAADEKVRQFLAKYGREHEYKPLAADPDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + +E + D TKLEPL+A PH  DN     E   +++++V IGSCT G+ ED   AA++ 
Sbjct: 255 HYANELQVDATKLEPLIAYPHRVDNVKPVSEFAGMELDQVCIGSCTNGRLEDLKVAAEIL 314

Query: 543 LASGGKKVKVPTFL 584
               GKKV   T L
Sbjct: 315 ---KGKKVHKDTRL 325

[170][TOP]
>UniRef100_B9AFU3 Putative uncharacterized protein n=1 Tax=Methanobrevibacter smithii
           DSM 2375 RepID=B9AFU3_METSM
          Length = 414

 Score =  150 bits (380), Expect = 5e-35
 Identities = 80/195 (41%), Positives = 118/195 (60%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD   V   G L  KVP T RF + G++ D + AKD+IL IIG++   G+TYK+
Sbjct: 135 STGIGSTDMAMVFAEGNLWFKVPETNRFEITGKLKDNVYAKDVILNIIGQMGADGSTYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            EF G TV  +++ +RM L NM +E GGK G++  D  T  Y+E +++ PY+   +D  A
Sbjct: 195 CEFAGETVSDMSISDRMVLTNMAIEMGGKTGLVEVDKKTIDYVESRSNKPYKVFKTDLDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
             L+    DV+ LEP VA PH+ DN     E  D +I++V++GSCT G+  D   AAK+ 
Sbjct: 255 PSLNIIDIDVSDLEPQVACPHNVDNVKPVSEV-DEEIDQVFLGSCTNGRLSDLRDAAKIL 313

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 314 KGKKIAKGTRMLVIP 328

[171][TOP]
>UniRef100_Q8PUG1 3-isopropylmalate dehydratase large subunit 2 n=1
           Tax=Methanosarcina mazei RepID=LEUC2_METMA
          Length = 420

 Score =  150 bits (380), Expect = 5e-35
 Identities = 78/183 (42%), Positives = 115/183 (62%), Gaps = 4/183 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD   V   GKL  +VP T RF ++G++P+ + +KDLIL +IG++ V G  Y +
Sbjct: 135 STGIGSTDMAAVFATGKLWFRVPETFRFEVEGKLPERVYSKDLILHLIGDVGVEGVRYMA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE----GKTSVPYESVYS 350
            E+ GST+ SL++ ERMT+ NM +E GGK G+I  D VT  YL+    G    PY    S
Sbjct: 195 AEYAGSTIRSLSIPERMTMSNMAIEMGGKAGIIEADEVTEAYLKERIPGFKLDPYWK--S 252

Query: 351 DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAA 530
           D+ A++L    +DV+ LEP VA PH+ DN     E +  K++++++GSCT G+ ED    
Sbjct: 253 DEGAKYLDIRYYDVSDLEPQVACPHNVDNVKPVSEVEGTKLDQIFMGSCTNGRFEDIKIM 312

Query: 531 AKV 539
           A +
Sbjct: 313 ADI 315

[172][TOP]
>UniRef100_C7LW15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LW15_DESBD
          Length = 420

 Score =  150 bits (379), Expect = 7e-35
 Identities = 75/195 (38%), Positives = 114/195 (58%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVP T+R    G++P+++  KDL+L  IG+  VAGA YK+
Sbjct: 136 ATGLGSTDIAAAMALGETWFKVPETIRVNFTGKLPEHVGGKDLVLFTIGQTGVAGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  +E L++E RMT+ NM +EAGGK G+   D  T  Y +    +    + +D+ A
Sbjct: 196 LEFGGEIIEGLSVEARMTMANMAIEAGGKAGLFAADEKTLAYCQAHGRMGDSPIAADEGA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  E  FDV+   P +A PH PDN     E  DV++++V +GSCT G+  D   AAK+ 
Sbjct: 256 HYWKEMTFDVSSFSPQIACPHLPDNVRPVEEVSDVRVDQVVLGSCTNGRISDLREAAKII 315

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 316 KGRKVAKGVRFIVIP 330

[173][TOP]
>UniRef100_A1VAE7 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           vulgaris DP4 RepID=LEUC_DESVV
          Length = 419

 Score =  150 bits (379), Expect = 7e-35
 Identities = 82/188 (43%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVPPT+R    G +P Y+ AKDLIL +IG I V GA Y++
Sbjct: 136 ATGLGSTDVAGAMALGETWFKVPPTIRATFTGTLPAYVGAKDLILTLIGAIGVDGALYRA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G+ +E+L++E RMT+ NM +EAGGK G+   D+ T  Y          +  +D  A
Sbjct: 196 LEFDGAAIEALDVEGRMTMANMAIEAGGKAGLFAADAKTLTYCTAAGRTGDAAFSADAGA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  E  FDVT + P+VA PH PDN     E KDV + +V IGSCT G+  D   AA V 
Sbjct: 256 VYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDVTVQQVVIGSCTNGRIGDLREAAAVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---RGRKV 320

[174][TOP]
>UniRef100_O28084 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Archaeoglobus
           fulgidus RepID=LEUC2_ARCFU
          Length = 416

 Score =  150 bits (379), Expect = 7e-35
 Identities = 77/190 (40%), Positives = 117/190 (61%), Gaps = 1/190 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   +VP + R  +DG +P  + AKD+IL++IG++ V GATYK+
Sbjct: 131 STGMGSTDVAVAIALGKNWFRVPESFRVQLDGSLPKGVFAKDVILKLIGDLGVDGATYKA 190

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL-EGKTSVPYESVYSDQQ 359
           +EF G   E++ +EER+T+ NM VE G K G+   D  T K+L E      +  V +D+ 
Sbjct: 191 LEFHGECAENMTVEERLTIANMAVECGAKAGIFESDENTRKFLAELGREGDFREVKADED 250

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A +  E   DV+ L P+V+KPH+ DN A   E +  ++N+VYIG+CT G+  D   AA++
Sbjct: 251 AEYEKEIYMDVSSLVPVVSKPHNVDNVAEISEVEGTEVNQVYIGTCTNGRLSDLEVAARI 310

Query: 540 FLASGGKKVK 569
                G+KVK
Sbjct: 311 L---KGRKVK 317

[175][TOP]
>UniRef100_UPI00016C5FE1 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile QCD-97b34 RepID=UPI00016C5FE1
          Length = 425

 Score =  150 bits (378), Expect = 9e-35
 Identities = 82/193 (42%), Positives = 116/193 (60%), Gaps = 5/193 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD G  +  GK   KVP  ++FV+  +   ++  KD+IL IIGEI V GA YKS
Sbjct: 136 STGVGSTDMGAGMATGKCWFKVPGAIKFVLKNKPNKWISGKDIILHIIGEIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG---KTSVPYESVY-S 350
           MEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+      T     ++Y +
Sbjct: 196 MEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYINSHKCSTITKDVNIYEA 255

Query: 351 DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFMA 527
           D+ A +   Y  D+ +L+  VA PH P+N     E  KD+KI++V IGSCT G+  D   
Sbjct: 256 DEDAVYDEVYEIDLAELKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLEV 315

Query: 528 AAKVFLASGGKKV 566
            A++     GKKV
Sbjct: 316 VAEIM---KGKKV 325

[176][TOP]
>UniRef100_C1DUH4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium azorense Az-Fu1
           RepID=C1DUH4_SULAA
          Length = 431

 Score =  150 bits (378), Expect = 9e-35
 Identities = 73/188 (38%), Positives = 116/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  ++   G+  L+VP T++F   G+   ++  KD +L +IG+I V GA YK+
Sbjct: 136 STGVGSTDIAYIWATGETWLRVPETMKFTFYGKPQKWVGGKDFVLTVIGKIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  +++L+++ R+T+ NM +EAGGKN VI  D  T +++  +T+  ++   SD  A
Sbjct: 196 MEYHGEAIKALDIDNRLTIANMAIEAGGKNAVIEADEKTIEWVRKRTNREFKIYKSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++  EY FD  K+EP+VA P+ P N     E     I++V+IGSCT G+  D   AA + 
Sbjct: 256 KYCCEYEFDANKIEPVVACPNLPSNVKPVSEVAGTHIDQVFIGSCTNGRLSDLRIAAAIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[177][TOP]
>UniRef100_C9XME3 3-isopropylmalate dehydratase large subunit n=2 Tax=Clostridium
           difficile RepID=C9XME3_CLODI
          Length = 364

 Score =  150 bits (378), Expect = 9e-35
 Identities = 82/193 (42%), Positives = 116/193 (60%), Gaps = 5/193 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD G  +  GK   KVP  ++FV+  +   ++  KD+IL IIGEI V GA YKS
Sbjct: 75  STGVGSTDMGAGMATGKCWFKVPGAIKFVLKNKPNKWISGKDIILHIIGEIGVDGALYKS 134

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG---KTSVPYESVY-S 350
           MEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+      T     ++Y +
Sbjct: 135 MEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYINSHKCSTITKDVNIYEA 194

Query: 351 DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFMA 527
           D+ A +   Y  D+ +L+  VA PH P+N     E  KD+KI++V IGSCT G+  D   
Sbjct: 195 DEDAVYDEVYEIDLAELKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLEV 254

Query: 528 AAKVFLASGGKKV 566
            A++     GKKV
Sbjct: 255 VAEIM---KGKKV 264

[178][TOP]
>UniRef100_C4FI11 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium yellowstonense SS-5
           RepID=C4FI11_9AQUI
          Length = 431

 Score =  150 bits (378), Expect = 9e-35
 Identities = 72/188 (38%), Positives = 117/188 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  ++   G+  L+VP +++FV   +   ++  KD +L +IG+I V GA YK+
Sbjct: 136 STGVGSTDIAYIWATGETWLRVPESMKFVFYNKPQKWVGGKDFVLTVIGKIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  +++L+++ R+T+ NM +EAGGK+G+I PD  T +++  +T   ++   SD  A
Sbjct: 196 MEYHGEAIKALDIDNRLTIANMAIEAGGKSGIIEPDEKTVEWVRKRTDREFKLYKSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++  EY FD +K+EP+VA P  P N     E     I++V+IGSCT G+  D   AA + 
Sbjct: 256 KYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTHIDQVFIGSCTNGRLSDLRIAAAIL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[179][TOP]
>UniRef100_A0B7V1 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosaeta
           thermophila PT RepID=A0B7V1_METTP
          Length = 423

 Score =  150 bits (378), Expect = 9e-35
 Identities = 85/195 (43%), Positives = 116/195 (59%), Gaps = 4/195 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD   V   GKL   VP TLR V+DG +   + +KD+IL+IIG+I   GA Y +
Sbjct: 143 ATGIGSTDMASVFATGKLWFMVPQTLRLVIDGRLRRRVTSKDVILRIIGDIGADGANYLA 202

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            EF GS VE +++ ERMT+ NM +E G K G++ PD VT  YL  K  +  E +  D+ A
Sbjct: 203 CEFAGSAVERMSIAERMTMTNMSIEMGAKAGLVEPDRVTMTYL--KEWLTEEPIRGDEDA 260

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            F  E  +DV  LEP VA PH  DN         VKI+++++GSCT G+ ED   AA+V 
Sbjct: 261 IF-EEKHWDVNDLEPQVAMPHRVDNVVPVSRLPHVKIDQIFLGSCTNGRFEDLKLAAEVM 319

Query: 543 ----LASGGKKVKVP 575
               +A G + + +P
Sbjct: 320 GDEPVARGVRMIVIP 334

[180][TOP]
>UniRef100_A5FR41 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FR41_DEHSB
          Length = 416

 Score =  149 bits (377), Expect = 1e-34
 Identities = 72/178 (40%), Positives = 108/178 (60%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD    +  G++ +KVP T++F   G++P ++  KDLIL  IG+  V GA Y +M
Sbjct: 134 TGMGSTDIAAAMATGEVWMKVPQTIKFNYSGKLPKWIGGKDLILYTIGQTGVDGALYSAM 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
            F G  +E+L+ME R T+ NM +EAGGK G+   D  T +Y+  +    Y    +D  A 
Sbjct: 194 FFCGEAIEALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQYTVYDNDADAS 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           +   Y FD++KLEP V+ PHSP N     +   +K+++V IGSCT G+ ED   +AK+
Sbjct: 254 YAKTYNFDISKLEPQVSLPHSPANARPVSQIGKIKVDQVIIGSCTNGRLEDLAVSAKL 311

[181][TOP]
>UniRef100_C6PJB4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacter italicus Ab9 RepID=C6PJB4_9THEO
          Length = 418

 Score =  149 bits (377), Expect = 1e-34
 Identities = 76/188 (40%), Positives = 114/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++FV+ G +  ++  KD+IL IIG+I V GA YKS
Sbjct: 135 STGVGSTDMAAAMATGKAWFKVPEAIKFVLKGNLQKWVSGKDIILYIIGKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G+ +++L+M++R T+ NM +EAG KNG+   D +T  Y++G+    Y+    D+ A
Sbjct: 195 MEFTGN-IKTLSMDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKREYKVFERDEDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  ++ ++ P VA PH P+N     E   VKI++V IGSCT G+  D   A K+ 
Sbjct: 254 EYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKVKIDQVVIGSCTNGRLSDMEIAYKIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[182][TOP]
>UniRef100_C6PDK3 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571
           RepID=C6PDK3_CLOTS
          Length = 418

 Score =  149 bits (377), Expect = 1e-34
 Identities = 77/188 (40%), Positives = 116/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  +RF + G++  ++  KD+IL IIG I V GA YKS
Sbjct: 135 STGIGSTDMACAMATGKAWFKVPEAIRFNLKGKLNKWVSGKDVILYIIGMIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + SL++++R T+ NM +EAG KNG+   D +T  Y++G+ +  Y+   +D+ A
Sbjct: 195 MEFTGD-ISSLSIDDRFTIANMAIEAGAKNGIFDYDEITETYVKGRANRKYKVFKADKDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++  Y  D++K++P VA PH P+N     E  ++KI++V IGSCT G+  D     +V 
Sbjct: 254 DYVESYDIDLSKIKPQVAFPHLPENTKPIDEVGNIKIDQVVIGSCTNGRISDMEVTYEVL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[183][TOP]
>UniRef100_C0B4W1 Putative uncharacterized protein n=1 Tax=Coprococcus comes ATCC
           27758 RepID=C0B4W1_9FIRM
          Length = 417

 Score =  149 bits (377), Expect = 1e-34
 Identities = 76/187 (40%), Positives = 114/187 (60%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD  + +  G   + VP T++F + G++P+ + A+DLIL IIGE+   G  Y+ M
Sbjct: 135 TGVGCTDFLYGMVTGTSWVMVPETVKFNLVGKLPEGVYARDLILTIIGEVGANGCNYQVM 194

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G   ++L + +R+ LCNM VEAG K G+   D V  +YL+     P    +SD  A 
Sbjct: 195 EFTGEGAKTLTISDRIALCNMAVEAGAKTGIFEVDDVAMEYLKEHGREPKAVYHSDPDAH 254

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           ++ EY FD++K+EP+VAKP   DN A A++ + +KI+  ++GSC  G+ ED    A+V  
Sbjct: 255 YVREYTFDLSKVEPVVAKPDFVDNLAPAKDVRGIKIDEAFLGSCNNGRIEDLRVGAQVI- 313

Query: 546 ASGGKKV 566
              GKKV
Sbjct: 314 --KGKKV 318

[184][TOP]
>UniRef100_A1HRB9 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HRB9_9FIRM
          Length = 420

 Score =  149 bits (377), Expect = 1e-34
 Identities = 81/189 (42%), Positives = 118/189 (62%), Gaps = 1/189 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A+G+G+T+   +L  GK  L+VP T++    G +PD ++AKD+ L+ IG I  AGATYK+
Sbjct: 135 ASGVGSTEMLGILLTGKTWLRVPETIKVEWTGRLPDGVMAKDMSLKTIGTIGHAGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGK-TSVPYESVYSDQQ 359
           +E+VG  + +L ++ERM + NM VE G K G++ PD+   +YL+ +  +  Y    SD  
Sbjct: 195 VEYVGDAITNLCLDERMAITNMAVEMGAKAGLMAPDTKVVEYLKARGITEGYTLFASDSD 254

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           A F + YRFD ++LEP+VA PH  DN       K   I++ YIGSCTGG+  D  AAA+V
Sbjct: 255 AVFCATYRFDASELEPVVACPHEVDNVTELSNVKGQVIHQAYIGSCTGGRYNDLAAAARV 314

Query: 540 FLASGGKKV 566
                G+KV
Sbjct: 315 L---KGRKV 320

[185][TOP]
>UniRef100_Q726X4 3-isopropylmalate dehydratase large subunit n=2 Tax=Desulfovibrio
           vulgaris RepID=LEUC_DESVH
          Length = 419

 Score =  149 bits (377), Expect = 1e-34
 Identities = 82/188 (43%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVPPT+R    G +P Y+ AKDLIL +IG I V GA Y++
Sbjct: 136 ATGLGSTDVAGAMALGETWFKVPPTIRATFTGTLPAYVGAKDLILTLIGAIGVDGALYRA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G+ +E+L++E RMT+ NM +EAGGK G+   D+ T  Y          +  +D  A
Sbjct: 196 LEFDGAAIEALDVEGRMTMANMAIEAGGKAGLFAADAKTLTYCTTAGRTGDTAFSADAGA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  E  FDVT + P+VA PH PDN     E KDV + +V IGSCT G+  D   AA V 
Sbjct: 256 VYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDVTVQQVVIGSCTNGRIGDLREAAAVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---RGRKV 320

[186][TOP]
>UniRef100_C6BSG9 3-isopropylmalate dehydratase, large subunit n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG9_DESAD
          Length = 419

 Score =  149 bits (376), Expect = 2e-34
 Identities = 77/179 (43%), Positives = 112/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVPPT++  ++G    Y+ AKD IL +IG I V+GA YK+
Sbjct: 136 ATGMGSTDIAGGMALGETWFKVPPTIKVEIEGTPGKYMGAKDYILNLIGTIGVSGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GS VE+L++E RMT+ NM +EAGGK G+ P D+ T +Y +         + +D+ A
Sbjct: 196 LEFSGSVVENLSIEGRMTIANMAIEAGGKVGLFPVDAKTLEYCKAAGRTGDVEMRADEGA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +    + DVT ++P VA PH PDN     E KD++I++  IGSCT G+ ED   AA +
Sbjct: 256 SYERVVKIDVTGMKPQVACPHLPDNVKPVDEVKDMRIHQAVIGSCTNGRIEDLREAAAI 314

[187][TOP]
>UniRef100_A9BGP4 3-isopropylmalate dehydratase, large subunit n=1 Tax=Petrotoga
           mobilis SJ95 RepID=A9BGP4_PETMO
          Length = 419

 Score =  149 bits (376), Expect = 2e-34
 Identities = 76/178 (42%), Positives = 107/178 (60%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD    +  G L  +VP +++ V  G++  ++  KDLIL  IG+I V GA YKS+
Sbjct: 135 TGVGSTDMAAAMATGYLWFRVPESIKIVYKGKLNPWVSGKDLILYTIGDIGVDGALYKSI 194

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G T+E L+M+ RMT+ NM +EAG K G+   D  T +YL+ +    Y  V SD  A 
Sbjct: 195 EFTGETIEDLSMDSRMTMANMAIEAGAKCGLFEYDEKTKEYLKERAVRDYTPVSSDPDAS 254

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           +     +DV+ +EP VA PH P+N     E K +KI++  IGSCT G+ ED   AA V
Sbjct: 255 YEEVIEYDVSNIEPQVAFPHLPENTKPVTEAKRIKIDQSVIGSCTNGRIEDLRIAAHV 312

[188][TOP]
>UniRef100_A5KNQ3 Putative uncharacterized protein n=1 Tax=Ruminococcus torques ATCC
           27756 RepID=A5KNQ3_9FIRM
          Length = 451

 Score =  149 bits (376), Expect = 2e-34
 Identities = 75/182 (41%), Positives = 109/182 (59%), Gaps = 3/182 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G++  KVP  ++FV+ G+   Y+  KD+I+ IIG+I V GA YKS
Sbjct: 142 STGMGTTDVATGMATGEIWFKVPSAIKFVLTGKPGKYVSGKDIIIHIIGKIGVDGALYKS 201

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + +L+M++R T+ NM +EAG KNG+ P D  T +YL+     PY    +D+ A
Sbjct: 202 MEFTGDGIGNLSMDDRFTMANMAIEAGAKNGIFPVDEKTVEYLDAHCEKPYTVYEADEDA 261

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALAREC---KDVKINRVYIGSCTGGKTEDFMAAA 533
            +      D++K+ P VA PH P N     E    + VKI++V IGSCT G+ ED   AA
Sbjct: 262 VYDDVVEIDLSKVRPTVAFPHLPGNAKTIDEIEAEEQVKIDQVVIGSCTNGRMEDMRKAA 321

Query: 534 KV 539
            +
Sbjct: 322 AI 323

[189][TOP]
>UniRef100_Q0W5L6 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W5L6_UNCMA
          Length = 421

 Score =  149 bits (376), Expect = 2e-34
 Identities = 74/197 (37%), Positives = 124/197 (62%), Gaps = 6/197 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD       GKL  KVP T+RF ++G + D + +KD+IL++IG++   GA YK+
Sbjct: 136 ATGIGSTDMAAAFALGKLWFKVPETIRFEVNGRLDDRVSSKDVILKLIGDVGADGARYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTS--VPYESVYSDQ 356
            E+ G  +ESL++ +RMT+ NM +E GGK G++ PD  T +Y++ +       +++ SD+
Sbjct: 196 CEYAGEVIESLDISQRMTISNMAIEMGGKAGIVEPDKKTEEYVKARVKGYKLDKNMKSDE 255

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A++     +D++++ P VA PH+ DN     E +  KI++V++GSCT G+ ED   AA+
Sbjct: 256 GAKYADVREYDLSEMPPQVACPHNVDNVVDISEVEGKKIDQVFLGSCTNGRFEDLKIAAE 315

Query: 537 VF----LASGGKKVKVP 575
           +     +A G + + +P
Sbjct: 316 IMGSKPVARGVRMIVIP 332

[190][TOP]
>UniRef100_B9L6Y8 3-isopropylmalate dehydratase large subunit n=1 Tax=Nautilia
           profundicola AmH RepID=LEUC_NAUPA
          Length = 425

 Score =  149 bits (376), Expect = 2e-34
 Identities = 83/195 (42%), Positives = 120/195 (61%), Gaps = 7/195 (3%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  F +  GK   K+P +++ V  GE  +++  KDLIL++I  I V GA YK+
Sbjct: 135 STGMGSTDIAFCMITGKSWFKIPESIKVVFKGERGEHVYGKDLILELIRRIGVDGALYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEG-KTSVPYESV----Y 347
           +EF G  +E+L M++RM+LCNM +EAG KNG++  D +T  +LE  K   P  S     Y
Sbjct: 195 LEFTGEVIENLPMDDRMSLCNMAIEAGAKNGIVAYDKITEAFLEEVKKYNPLRSEPKIHY 254

Query: 348 SDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINRVYIGSCTGGKTEDF 521
           SD  A +      DV KLEPLVA P  P N + +++  K D++I++VYIGSCT G   D 
Sbjct: 255 SDPDANYSQVIEIDVNKLEPLVAYPFLPSNGKPISQAVKDDIEIDQVYIGSCTNGTLSDL 314

Query: 522 MAAAKVFLASGGKKV 566
             AA++     GK+V
Sbjct: 315 RIAAEIL---KGKRV 326

[191][TOP]
>UniRef100_B8DM92 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=LEUC_DESVM
          Length = 418

 Score =  149 bits (376), Expect = 2e-34
 Identities = 82/190 (43%), Positives = 117/190 (61%), Gaps = 2/190 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG G+TD    +  G+   KVPPT+R    G +P ++ AKDLIL++IGEI V GA Y++
Sbjct: 136 ATGFGSTDVAGAMALGETWFKVPPTIRATFTGTLPKWVGAKDLILRLIGEIGVDGALYRA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKY--LEGKTSVPYESVYSDQ 356
           +EF G+ +E+L++E RMT+ NM +EAGGK G+   D+ T  Y    G+   P   + +D 
Sbjct: 196 LEFDGAAIEALSVEGRMTIANMAIEAGGKAGLFAADAKTLAYTAARGRKDAP---LSADP 252

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A +  E  FDV+ +EPLVA PH P+N     E + V +++V IGSCT G+  D   AA+
Sbjct: 253 GATYERELTFDVSGMEPLVACPHLPENVKPVGEVRGVTLDQVVIGSCTNGRISDMREAAE 312

Query: 537 VFLASGGKKV 566
           V     G+KV
Sbjct: 313 VL---KGRKV 319

[192][TOP]
>UniRef100_Q3ZXI5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. CBDB1 RepID=Q3ZXI5_DEHSC
          Length = 416

 Score =  149 bits (375), Expect = 2e-34
 Identities = 71/178 (39%), Positives = 108/178 (60%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD    +  G++ +KVP T++F   G++P ++  KDLIL  IG+  V GA Y +M
Sbjct: 134 TGMGSTDIAAAMATGEVWMKVPQTIKFNYSGKLPKWIGGKDLILYTIGQTGVDGALYSAM 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
            F G  +E+L+ME R T+ NM +EAGGK G+   D  T +Y+  +    Y    +D  A 
Sbjct: 194 FFCGEAIEALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYVTPRAKRQYTVYDNDADAS 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           +   Y FD++K+EP V+ PHSP N     +   +K+++V IGSCT G+ ED   +AK+
Sbjct: 254 YAKTYNFDISKIEPQVSLPHSPANARPVSQIGKIKVDQVIIGSCTNGRLEDLAVSAKL 311

[193][TOP]
>UniRef100_A4J6Z5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum reducens MI-1 RepID=A4J6Z5_DESRM
          Length = 418

 Score =  149 bits (375), Expect = 2e-34
 Identities = 75/188 (39%), Positives = 113/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    L +GK+  KVP T++FV +G +P  + AKDLIL +IG++T  G TY +
Sbjct: 133 STGVGSTDLAGGLISGKMWFKVPETIKFVCNGVLPSGVYAKDLILYLIGQVTADGCTYMA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            E+ G  + +L+ME R T+ NM +E G K G++  D  T+ +L+  T   + +V +D  A
Sbjct: 193 AEYTGEAIAALSMEGRFTISNMAIEMGAKAGLMEADDKTFAWLKQYTERQFTAVSADANA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      DV+ LEP VAKPH  DN +   E K + I + ++G+CT G+ ED   AA + 
Sbjct: 253 NYYKVLELDVSNLEPQVAKPHRVDNVSPLSEVKGLPIQQAFLGTCTNGRLEDLRIAASIL 312

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 313 ---AGKKV 317

[194][TOP]
>UniRef100_A0ZF76 3-isopropylmalate dehydratase, LeuC subunit n=1 Tax=Nodularia
           spumigena CCY9414 RepID=A0ZF76_NODSP
          Length = 574

 Score =  149 bits (375), Expect = 2e-34
 Identities = 71/179 (39%), Positives = 108/179 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           + G+G TD   +   G + ++VP TL F + G +P ++ AKD+IL I+G+I  AGAT K 
Sbjct: 292 SAGVGTTDMANIYAMGDMWIRVPSTLVFELSGTLPPHISAKDIILFILGQIGCAGATSKV 351

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF GS +E +  +ER+TL NM +E G   G+I PD  T  Y+  ++   +E + +D  A
Sbjct: 352 MEFRGSILEQMPFDERLTLANMAIECGAICGLIVPDETTRNYVRSRSDQEFEELIADPDA 411

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y+FD++ LEP +A+P  PD      + ++  I + +IGSCTGGK  D   AA+V
Sbjct: 412 EYEKVYKFDISNLEPQIARPPKPDQVVPISQIEETPITKAFIGSCTGGKLYDLAQAAEV 470

[195][TOP]
>UniRef100_B1H0A6 3-isopropylmalate dehydratase large subunit n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=LEUC_UNCTG
          Length = 420

 Score =  149 bits (375), Expect = 2e-34
 Identities = 75/188 (39%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG G+TD    +  GK+  KVP +++F+++ ++  ++  KD+IL IIG I V GA Y S
Sbjct: 136 STGGGSTDIAAAMATGKIWFKVPNSIKFILNRKLNKWVSGKDIILYIIGLIGVDGALYNS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G   + L M +R T+ NM +EAGGKNG+  PD +T  Y+  +    Y+   SD+ A
Sbjct: 196 MEFDGPLCKKLTMADRFTITNMAIEAGGKNGIFTPDEITENYVAKRAQRKYKFYISDKDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
           ++L  Y  D +K+ P V+ P  P N    ++ K   I++V IGSCT G+ ED   AA + 
Sbjct: 256 KYLKIYEIDCSKILPQVSMPFLPSNTKAVKDIKKTYIDQVVIGSCTNGRIEDLRVAASII 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 --KKGKKV 321

[196][TOP]
>UniRef100_C8PKG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           gracilis RM3268 RepID=C8PKG7_9PROT
          Length = 421

 Score =  148 bits (374), Expect = 3e-34
 Identities = 79/197 (40%), Positives = 120/197 (60%), Gaps = 3/197 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD  F +  GK   KVPPT++ +  G+   ++  KDLIL++I  I V GA YK+
Sbjct: 135 ATGMGSTDLAFAMITGKNWFKVPPTIKVIFHGKPAPHIYGKDLILEVIRLIGVDGARYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKT-SVPYESVYSDQQ 359
           +EF G  +E L+M+ R +LCNM +EAGGK+G++  D +T ++L  K      +  YSD+ 
Sbjct: 195 LEFCGDALEYLDMDSRFSLCNMAIEAGGKSGIVAVDEITKEFLADKNLRAEPKFHYSDEG 254

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRVYIGSCTGGKTEDFMAAA 533
           A +    + DV+KL+P++A P  P N    RE    D+ +++V+IGSCT G+  D   AA
Sbjct: 255 ANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVRDDIAVDQVFIGSCTNGRLSDLRIAA 314

Query: 534 KVFLASGGKKVKVPTFL 584
           ++     G+KV   T L
Sbjct: 315 QIL---KGRKVARKTRL 328

[197][TOP]
>UniRef100_C0FIT9 Putative uncharacterized protein n=1 Tax=Clostridium sp. M62/1
           RepID=C0FIT9_9CLOT
          Length = 278

 Score =  148 bits (374), Expect = 3e-34
 Identities = 77/181 (42%), Positives = 112/181 (61%)
 Frame = +3

Query: 27  AGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSMEFVGSTV 206
           AG V   GK   KVP  ++FV+ G+   ++  KD+IL IIG I V GA YKSMEF G  +
Sbjct: 3   AGMV--TGKAWFKVPSAIKFVLTGKPGKWVSGKDVILHIIGMIGVDGALYKSMEFTGDGI 60

Query: 207 ESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQARFLSEYRF 386
            +L+M++R T+CNM +EAGGKNG+ P D    +Y++  +   ++   +D+ A + + Y  
Sbjct: 61  RNLSMDDRFTICNMAIEAGGKNGIFPVDEKAVQYMKEHSKREFQIHEADEDAEYEAVYTI 120

Query: 387 DVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV 566
           D++ L+P VA PH P+N     E  DV I++V IGSCT G+ ED   AA++     G+KV
Sbjct: 121 DLSALKPTVAFPHLPENTKTIDEAGDVAIDQVVIGSCTNGRLEDMRIAAEIL---KGRKV 177

Query: 567 K 569
           K
Sbjct: 178 K 178

[198][TOP]
>UniRef100_A1HUD1 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HUD1_9FIRM
          Length = 419

 Score =  148 bits (374), Expect = 3e-34
 Identities = 79/187 (42%), Positives = 115/187 (61%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TGIG+T+   VL +G++ L+VP T+ FV  G++   + AKD+IL+ I EI  AGATYK M
Sbjct: 136 TGIGSTEMLGVLVSGQIWLRVPETMLFVWHGKLQQGVYAKDIILRTIKEIGQAGATYKVM 195

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF GS +E+L+++ERMT+ NM VEAG K G++ PD   + YLE   +     +YSD  A 
Sbjct: 196 EFAGSCIENLSVDERMTIANMAVEAGAKTGLMAPDDKVFAYLESIGAPKGTPLYSDPDAE 255

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           +  ++ F+   L P +A PH  D      E +   I++ Y+GSCT G+  D + AAK+  
Sbjct: 256 YAQKFEFNADTLVPQIALPHEVDKVVDITEAEGEVIHQAYLGSCTNGRYPDLVEAAKIL- 314

Query: 546 ASGGKKV 566
              G+KV
Sbjct: 315 --KGRKV 319

[199][TOP]
>UniRef100_UPI000196B289 hypothetical protein CATMIT_00953 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196B289
          Length = 425

 Score =  148 bits (373), Expect = 3e-34
 Identities = 78/191 (40%), Positives = 110/191 (57%), Gaps = 3/191 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+L  KVP  ++F + G++P Y+  KD+IL IIG I V GA YKS
Sbjct: 135 STGVGTTDIATGMATGQLWFKVPSAIKFNLHGKLPKYVSGKDVILHIIGRIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V+ L+M +R T+CNM +EAG KNG+ P D    +YL+      Y+   +D+ A
Sbjct: 195 MEFTGEGVKELSMADRFTICNMAIEAGAKNGIFPVDEAAIEYLDKHAKRDYKIYEADKDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECK---DVKINRVYIGSCTGGKTEDFMAAA 533
            +      D++ + P VA PH P N     E +    + I++V IGSCT G+ ED   AA
Sbjct: 255 EYEEIVDVDLSAIRPTVAFPHLPGNAKTVDEIEAMDKIYIDQVVIGSCTNGRMEDLRKAA 314

Query: 534 KVFLASGGKKV 566
            +     GKKV
Sbjct: 315 AIL---KGKKV 322

[200][TOP]
>UniRef100_B2V844 3-isopropylmalate dehydratase large subunit n=1
           Tax=Sulfurihydrogenibium sp. YO3AOP1 RepID=LEUC_SULSY
          Length = 431

 Score =  148 bits (373), Expect = 3e-34
 Identities = 68/179 (37%), Positives = 112/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  ++   G+  L+VP +++FV   +   ++  KD +L +IG+I V GA YK+
Sbjct: 136 STGVGSTDIAYIWATGETWLRVPESMKFVFYNKPQKWVGGKDFVLTVIGKIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           ME+ G  + +L+++ R+T+ NM +EAGGK+G+I PD  T  ++  +T+  ++   SD  A
Sbjct: 196 MEYQGEAIRALDIDNRLTIANMAIEAGGKSGIIEPDEKTVDWVRKRTNREFKLYKSDPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           ++  EY FD +K+EP+VA P  P N     E     I++V+IGSCT G+  D   AA +
Sbjct: 256 KYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTHIDQVFIGSCTNGRLSDLRIAAAI 314

[201][TOP]
>UniRef100_C7II84 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           papyrosolvens DSM 2782 RepID=C7II84_9CLOT
          Length = 419

 Score =  147 bits (372), Expect = 5e-34
 Identities = 72/179 (40%), Positives = 111/179 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  G+   KVP  ++FV+ G+   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGEAWFKVPEAIKFVLKGKPQKWVGGKDVILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V +L+M++R ++ NM +EAG KNG+   D  T +Y++  +   Y    +D+ A
Sbjct: 196 MEFTGDGVNALSMDDRFSMANMAIEAGAKNGIFEVDEKTVEYVKEHSIRSYTVYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           ++   Y  D+ +++P VA PH P+N     +  D+KI++V IGSCT G+ ED   AA++
Sbjct: 256 QYSEVYEIDLAEIKPTVAFPHLPENARTIDKVGDIKIDQVVIGSCTNGRIEDMRIAAQI 314

[202][TOP]
>UniRef100_B1C4Q4 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C4Q4_9FIRM
          Length = 424

 Score =  147 bits (372), Expect = 5e-34
 Identities = 77/191 (40%), Positives = 111/191 (58%), Gaps = 3/191 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+L  KVP  ++F++ G+   Y+  KD+IL II +I V GA YKS
Sbjct: 135 STGVGTTDIATGMATGELWFKVPEAIKFILTGKPSKYVSGKDIILHIINKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  ++ L M++R T+CNM +EAG KNG+ P D  T  Y+E  +   Y+   +D+ A
Sbjct: 195 MEFVGDGIQYLTMDDRFTICNMAIEAGAKNGIFPVDDQTIAYMEEHSKKDYKVYTADEDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRVYIGSCTGGKTEDFMAAA 533
            +      D++K+ P VA PH P N     E    + + I++V IGSCT G+  D   AA
Sbjct: 255 EYERVIEIDLSKVRPTVAFPHLPGNGHTIDEIEAMEPIYIDQVVIGSCTNGRISDLRKAA 314

Query: 534 KVFLASGGKKV 566
            +     GKKV
Sbjct: 315 AIL---KGKKV 322

[203][TOP]
>UniRef100_A6BFK8 Putative uncharacterized protein n=1 Tax=Dorea longicatena DSM
           13814 RepID=A6BFK8_9FIRM
          Length = 424

 Score =  147 bits (372), Expect = 5e-34
 Identities = 75/182 (41%), Positives = 110/182 (60%), Gaps = 3/182 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+L  KVP  ++FV+ G+   Y+  KD+I+ IIG+I V GA YKS
Sbjct: 135 STGVGTTDIATGMAMGELWFKVPSAIKFVLTGKPGKYVSGKDIIIHIIGKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L+M +R T+ NM +EAG KNG+ P D  T +YL+  T   Y+   +D  A
Sbjct: 195 MEFTGDGIKNLSMADRFTMANMAIEAGAKNGIFPVDEKTEEYLKEHTKKEYKVYEADGDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRVYIGSCTGGKTEDFMAAA 533
            + S    D++++ P VA PH P N     E    + +KI++V IGSCT G+ ED   AA
Sbjct: 255 EYESVVEIDLSEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTNGRMEDMRKAA 314

Query: 534 KV 539
            +
Sbjct: 315 AI 316

[204][TOP]
>UniRef100_B0K0Y2 3-isopropylmalate dehydratase large subunit n=4
           Tax=Thermoanaerobacter RepID=LEUC_THEPX
          Length = 418

 Score =  147 bits (372), Expect = 5e-34
 Identities = 75/188 (39%), Positives = 114/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++FV+ G +  ++  KD+IL IIG+I V GA YKS
Sbjct: 135 STGVGSTDMAAAMATGKAWFKVPEAIKFVLKGNLQKWVSGKDVILYIIGKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G+ +++L++++R T+ NM +EAG KNG+   D +T  Y++G+    Y+    D+ A
Sbjct: 195 MEFTGN-IKALSIDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKREYKVFERDEDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  ++ ++ P VA PH P+N     E   VKI++V IGSCT G+  D   A K+ 
Sbjct: 254 EYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKVKIDQVVIGSCTNGRLSDMEIAYKIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[205][TOP]
>UniRef100_B8I4G0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I4G0_CLOCE
          Length = 419

 Score =  147 bits (371), Expect = 6e-34
 Identities = 77/188 (40%), Positives = 112/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  GK   KVP  ++FV+ G+   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGKAWFKVPEAIKFVLRGKPQKWVGGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V +L+M++R ++ NM +EAG KNG+   D  T +Y++  +   Y    +D+ A
Sbjct: 196 MEFTGDGVNALSMDDRFSMANMAIEAGAKNGIFEVDEKTVEYVKEHSIRHYTVYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y  D+ +++P VA PH P+N        D+KI++V IGSCT G+ ED   AA V 
Sbjct: 256 EYSEVYEIDLAEVKPTVAFPHLPENARTIDNVGDIKIDQVVIGSCTNGRIEDMRIAAGVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[206][TOP]
>UniRef100_A1HRB1 3-isopropylmalate dehydratase n=1 Tax=Thermosinus carboxydivorans
           Nor1 RepID=A1HRB1_9FIRM
          Length = 417

 Score =  147 bits (371), Expect = 6e-34
 Identities = 74/187 (39%), Positives = 112/187 (59%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD   ++  G L  +VP  +R  ++GE+P  + AKD+IL++IG +    A YK++
Sbjct: 133 TGVGATDLATIMITGHLWFRVPEIVRINLEGELPKGVYAKDIILKVIGTLGADYAVYKAV 192

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  ++ L++ ERM LCNM  E G K   I PD +T +YL+ K    YE  ++D   +
Sbjct: 193 EFTGPVLKQLSVSERMALCNMTTEMGAKTSYIQPDEITLEYLKDKVKGDYEIFHTDPGYQ 252

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           + +E+ FDV+ L+P VA PHS DN     E     + + ++G+CTGG+ +D   AAK+  
Sbjct: 253 YAAEHTFDVSGLKPQVAAPHSVDNVHDITEYIGRPVQQAFLGTCTGGRVQDLAVAAKIL- 311

Query: 546 ASGGKKV 566
              GKKV
Sbjct: 312 --KGKKV 316

[207][TOP]
>UniRef100_B1L3C3 Homoaconitate hydratase family protein n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L3C3_KORCO
          Length = 384

 Score =  147 bits (371), Expect = 6e-34
 Identities = 83/189 (43%), Positives = 114/189 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           + GIG T+    L  GKL  +VP T+   +DG +P+ + AKD+IL++I  I V GA YK+
Sbjct: 102 SVGIGATEMAAALIMGKLWFRVPETILVKLDGSLPEMVFAKDIILKLISMIGVDGANYKA 161

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GS ++ + M+ER  L NM VEAG K  +IP D VT  YL G+        YSD  +
Sbjct: 162 LEFNGSILKVMEMDERFVLTNMSVEAGAKTAIIPVDDVTLSYLNGRLRRAPRPEYSDDGS 221

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
               E   DV+ LEPLVA PHSP N   A E  D +I++ +IGSCTGG+ +D   AA++ 
Sbjct: 222 H-SDEISIDVSSLEPLVAIPHSPANVKPASEV-DAEIDQAFIGSCTGGRLKDLEVAARIL 279

Query: 543 LASGGKKVK 569
               G++VK
Sbjct: 280 ---RGRRVK 285

[208][TOP]
>UniRef100_A3DHI4 3-isopropylmalate dehydratase large subunit n=3 Tax=Clostridium
           thermocellum RepID=LEUC_CLOTH
          Length = 419

 Score =  147 bits (371), Expect = 6e-34
 Identities = 74/188 (39%), Positives = 115/188 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  G+   KVP  ++FV+ G+   ++  KD+IL IIG I V GA Y+S
Sbjct: 136 STGIGSTDMAAGMATGEAWFKVPEAMKFVLKGKPGKWVSGKDIILHIIGMIGVDGALYRS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  V  L+M++R  + NM +EAG KNG+   D  T +Y++  ++  Y+   +D+ A
Sbjct: 196 MEFTGDGVAHLSMDDRFAMANMAIEAGAKNGIFEVDEKTIEYVKEHSTRQYKVYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +++ Y  D+++++P VA PH P N        ++KI++V IGSCT G+ ED   AA+V 
Sbjct: 256 EYVATYEIDLSQVKPTVAFPHLPSNTRTIDNVGNIKIDQVVIGSCTNGRIEDLRVAAEVL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[209][TOP]
>UniRef100_C9LTJ0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Selenomonas
           sputigena ATCC 35185 RepID=C9LTJ0_9FIRM
          Length = 420

 Score =  147 bits (370), Expect = 8e-34
 Identities = 75/178 (42%), Positives = 106/178 (59%), Gaps = 1/178 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+   KVP T+   + GE P  +  KD+IL +IG I V GA YKS
Sbjct: 135 STGVGTTDLAVGMATGRAWFKVPETIEVHLTGEKPADVNGKDVILTLIGMIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V +L M +R+T+ NM +EAG KNG+ P D  T +Y+EG+    YE V SD  A
Sbjct: 195 LEFTGEGVAALTMTDRLTIANMAIEAGAKNGIFPFDEKTKEYVEGRVKGAYEPVTSDADA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARE-CKDVKINRVYIGSCTGGKTEDFMAAA 533
           ++      D++ L P+VA PH P N     +  + +KI++V IGSCT G+ ED   +A
Sbjct: 255 KYCRTVEIDLSSLRPVVAFPHLPGNTKRVMDIAEPIKIDQVVIGSCTNGRLEDLEISA 312

[210][TOP]
>UniRef100_C9L6F6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Blautia
           hansenii DSM 20583 RepID=C9L6F6_RUMHA
          Length = 425

 Score =  147 bits (370), Expect = 8e-34
 Identities = 74/180 (41%), Positives = 110/180 (61%), Gaps = 1/180 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  +R  + G+   ++  KD+IL +IG+I V GA YKS
Sbjct: 139 STGVGSTDMAAAMVTGKAWFKVPSAIRINLIGKPSKWVSGKDVILHLIGKIGVDGALYKS 198

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V++L+M++R T+ NM +EAG KNG+ P D  T +Y++  +  PY+    D+ A
Sbjct: 199 LEFTGEGVKNLSMDDRFTIANMAIEAGAKNGIFPVDEKTEEYMKEHSKRPYKRYEPDEDA 258

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-DVKINRVYIGSCTGGKTEDFMAAAKV 539
            +  EY  D++KL P VA PH P N     E + DV I +  IGSCT G+ +D   AA++
Sbjct: 259 VYDEEYTIDLSKLRPTVAFPHLPSNTKTIDEIQDDVIIQQSVIGSCTNGRIDDLRCAAQI 318

[211][TOP]
>UniRef100_C0C2K0 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0C2K0_9CLOT
          Length = 417

 Score =  147 bits (370), Expect = 8e-34
 Identities = 80/188 (42%), Positives = 110/188 (58%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           A+G+G+T+   +L  GK  LKVP T+R + +GE+   ++AKD+ L+ IG +  AGATY S
Sbjct: 135 ASGVGSTEMLGILVTGKTWLKVPETVRVLWEGELSANVMAKDISLRTIGTVGHAGATYMS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +E+ G T+  L ++ERM + NM VE G K G++P D +T  YL+      YE   SD  A
Sbjct: 195 VEYDGQTIRGLPVDERMAITNMAVEMGAKAGLMPFDDITEAYLDSIGVKDYEPYQSDADA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            F   Y+F   +L P VA PH  D    A   +DVKI + Y+GSCTGG+  D   AA   
Sbjct: 255 SFYRTYQFRAEELRPQVACPHEVDRVTEADNVRDVKIQQAYLGSCTGGRLHDLKTAAAYL 314

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 315 ---KGKKV 319

[212][TOP]
>UniRef100_B0G7V2 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G7V2_9FIRM
          Length = 425

 Score =  147 bits (370), Expect = 8e-34
 Identities = 74/182 (40%), Positives = 107/182 (58%), Gaps = 3/182 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+L  KVP  ++FV+ G+   Y+  KD+I+ IIG+I V GA YKS
Sbjct: 135 STGVGTTDIATGMAMGELWFKVPAAIKFVLTGKPGKYVSGKDIIIHIIGKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  + +L+M++R T+ NM +EAG KNG+ P D  T +YL   T   Y    +D+ A
Sbjct: 195 MEFTGDGIANLSMDDRFTMANMAIEAGAKNGIFPVDDKTIQYLNEHTKKEYTVYEADEDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRVYIGSCTGGKTEDFMAAA 533
            +      D+ ++ P VA PH P N     E    + +KI++V IGSCT G+ ED   AA
Sbjct: 255 EYEQVVEIDLAEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTNGRMEDMRKAA 314

Query: 534 KV 539
            +
Sbjct: 315 AI 316

[213][TOP]
>UniRef100_A3CWX5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanoculleus
           marisnigri JR1 RepID=A3CWX5_METMJ
          Length = 417

 Score =  147 bits (370), Expect = 8e-34
 Identities = 76/196 (38%), Positives = 112/196 (57%), Gaps = 5/196 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATGIG+TD GFVL  G L  +VP ++R  ++G     + AKDLIL + G+I   GATY +
Sbjct: 133 ATGIGSTDMGFVLKFGALYFRVPESIRIEVEGAFGRRVGAKDLILSLAGDIGADGATYMA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  + ++NM  RMT  NM +E G K G++ PD+ T+ Y+  +  +    +  D  A
Sbjct: 193 LEFTGDAMHTMNMAGRMTCANMAIEMGAKAGIVTPDAATWDYVAARRDIEPFDLAGDPDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +     +DVT L P VA PH+ DN     +    K+++V+IGSCT G+ ED   AA+V 
Sbjct: 253 EYRERRHYDVTDLAPQVAVPHNVDNVVDVGKVAGTKVDQVFIGSCTNGRYEDLAEAAEVL 312

Query: 543 -----LASGGKKVKVP 575
                 A G + + +P
Sbjct: 313 GNADRFADGVRVIVIP 328

[214][TOP]
>UniRef100_B0KAH5 3-isopropylmalate dehydratase large subunit n=3
           Tax=Thermoanaerobacter RepID=LEUC_THEP3
          Length = 417

 Score =  147 bits (370), Expect = 8e-34
 Identities = 76/188 (40%), Positives = 112/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  GK   KVP  ++FV+ G +  ++  KD+IL IIG+I V GA YKS
Sbjct: 135 STGVGSTDMAAAMATGKAWFKVPEAIKFVLKGNLQKWVSGKDVILYIIGKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G+ +++L+M++R T+ NM +EAG KNG+   D +T  Y++G+    Y+    D  A
Sbjct: 195 MEFTGN-IKALSMDDRFTIANMAIEAGAKNGIFDFDEITEAYVKGRAKREYKVFERDVDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +   Y   + ++ P VA PH P+N     E   VKI++V IGSCT G+  D   A K+ 
Sbjct: 254 EYSEVYEISLDEIRPQVAFPHLPENTRNIDEVGKVKIDQVVIGSCTNGRISDMEIAYKIL 313

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 314 ---KGKKV 318

[215][TOP]
>UniRef100_B2TIQ9 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum B str. Eklund 17B RepID=LEUC_CLOBB
          Length = 419

 Score =  147 bits (370), Expect = 8e-34
 Identities = 76/189 (40%), Positives = 109/189 (57%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  G+   KVP  ++F++  +   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGQTWFKVPSAIKFILKNKPAKWVSGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL+  T   +E   +D+ A
Sbjct: 196 MEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDDKTVEYLKEHTKKEWEVYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      ++  L P V+ PH PDN        D+ I++V IGSCT G+  D   A  + 
Sbjct: 256 EYDEVIEIELNTLRPTVSFPHLPDNTRTIDNVGDIDIDQVVIGSCTNGRISDLRIARDIL 315

Query: 543 LASGGKKVK 569
               GKKVK
Sbjct: 316 ---KGKKVK 321

[216][TOP]
>UniRef100_C9KK15 Homoaconitate hydratase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KK15_9FIRM
          Length = 423

 Score =  146 bits (369), Expect = 1e-33
 Identities = 72/194 (37%), Positives = 115/194 (59%), Gaps = 4/194 (2%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD   +L  G+L  KVP  +R  + G++P  + AKD++L IIG++    A YK++
Sbjct: 133 TGVGATDLAVILATGRLWFKVPEVIRINLTGKIPAGVYAKDIVLSIIGKLKADYAVYKAV 192

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  ++ L++ ERM LCNM  E G K   I PD++T ++L+ +    +    +D    
Sbjct: 193 EFAGPALQQLSISERMALCNMTTEMGAKTSYIQPDAITLQFLKERGRQDFTVYETDADYV 252

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF- 542
           + ++  FDV+++EP +A P S DN         + +++ Y+GSCTGG+TEDF  AAK+  
Sbjct: 253 YAADLTFDVSEVEPQLAAPFSVDNVQALSAYAGMHVDQAYLGSCTGGRTEDFAVAAKILA 312

Query: 543 ---LASGGKKVKVP 575
              + +G + V VP
Sbjct: 313 GQHIPAGTRMVMVP 326

[217][TOP]
>UniRef100_B0NXK3 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1
           RepID=B0NXK3_9CLOT
          Length = 413

 Score =  146 bits (369), Expect = 1e-33
 Identities = 72/188 (38%), Positives = 121/188 (64%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ++GIG T+   +LG G++ ++VP T++ V+DG++P+ + +KD+IL++IG++T AGATYK+
Sbjct: 134 SSGIGYTEMAAILGTGEMWVRVPETIKVVIDGKLPENVSSKDIILRLIGDLTAAGATYKA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GSTV+ +++  RMT+ NM +EAG K  +  PD  T +Y +   +   + +Y D+ A
Sbjct: 194 LEFSGSTVDEMSVAARMTMSNMAIEAGAKAALFAPDEKTAEYSKVDLA-DVDWLYGDEDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +     +    L P+VA P   D     +E +  ++++V+IGSCT G+ ED  AAA++ 
Sbjct: 253 EYCQTITYKAEDLVPVVACPSQVDKIRAVKEVEGTELDQVFIGSCTNGRLEDLKAAAEIL 312

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 313 ---KGKKV 317

[218][TOP]
>UniRef100_Q12UW0 Homoaconitase large subunit n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=Q12UW0_METBU
          Length = 428

 Score =  146 bits (369), Expect = 1e-33
 Identities = 72/181 (39%), Positives = 112/181 (61%), Gaps = 2/181 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD   V  +GKL  +VP T+RF  +G++P ++ +KDLIL +IG++   GA Y +
Sbjct: 143 STGVGSTDMSAVFASGKLWFRVPETIRFEANGKLPKHVYSKDLILHMIGDVGAEGARYMA 202

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVY--SDQ 356
            E+ GS +E L + ERMT+ NM +E GGK G+I  D  T  YL+ +        Y  SD+
Sbjct: 203 AEYAGSAIEGLTISERMTISNMAIEMGGKAGIIEADKTTEAYLKERIPDYEFDPYWKSDE 262

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A +   + ++V+ LEP VA PH+ DN     E +  K+++V++GSCT G+ ED    A+
Sbjct: 263 DAEYAEFHDYNVSDLEPQVACPHNVDNVKPVSEVEGTKVDQVFVGSCTNGRFEDIKIVAE 322

Query: 537 V 539
           +
Sbjct: 323 M 323

[219][TOP]
>UniRef100_B9LMV9 3-isopropylmalate dehydratase n=1 Tax=Halorubrum lacusprofundi ATCC
           49239 RepID=B9LMV9_HALLT
          Length = 437

 Score =  146 bits (369), Expect = 1e-33
 Identities = 77/197 (39%), Positives = 117/197 (59%), Gaps = 7/197 (3%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD G  L  G+L  +VP TLRF ++G++PD + AKDLIL+ IG++   G TYK+ 
Sbjct: 137 TGVGSTDLGTTLATGELWFRVPETLRFEVEGDLPDGVYAKDLILKFIGDVGFDGCTYKTA 196

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSV-PYESVYS--DQ 356
           E+ GS VE+L + ER+ L NM +E GGK G++PPD  T  +LE +T   P    Y+  D 
Sbjct: 197 EYGGSAVEALPIHERLVLSNMAIEMGGKAGIVPPDERTLDFLEAQTGERPEIPAYTQPDD 256

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAK 536
            A + + + +    L P V+ P +P+N     E    +I+++++G+CT G+ ED    A 
Sbjct: 257 DADYEAVHTYQAESLSPQVSTPSNPENAVPVDEVVGTEIDQLFVGTCTNGRYEDIRIVAD 316

Query: 537 VF----LASGGKKVKVP 575
           +     LA   + V VP
Sbjct: 317 IIEGEQLAPDTRMVVVP 333

[220][TOP]
>UniRef100_A5ZNE1 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC
           29174 RepID=A5ZNE1_9FIRM
          Length = 416

 Score =  146 bits (368), Expect = 1e-33
 Identities = 74/187 (39%), Positives = 112/187 (59%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD  + +  G   + VP +++F + G++P+ + A+DLIL IIGE+   G  Y+ M
Sbjct: 134 TGVGCTDFLYGMVTGTSWVLVPESVKFNLTGKLPEGVTARDLILTIIGEVGANGCNYQVM 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G   ++L++ +RMTLCNM VEAG K G+   D    +YL+     P    +SD  A+
Sbjct: 194 EFTGEGAKTLSISDRMTLCNMAVEAGAKTGIFEADEKAMEYLKEHGREPKAVFHSDPDAK 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           ++ EY FD++K+ P+VAKP   DN   A E   ++IN  ++GSC  G+ ED    A++  
Sbjct: 254 YVREYTFDLSKVRPVVAKPDFVDNVVPAEEACGIEINEAFLGSCNNGRIEDLRVGAEII- 312

Query: 546 ASGGKKV 566
              GKKV
Sbjct: 313 --KGKKV 317

[221][TOP]
>UniRef100_B1L5I9 3-isopropylmalate dehydratase n=1 Tax=Candidatus Korarchaeum
           cryptofilum OPF8 RepID=B1L5I9_KORCO
          Length = 413

 Score =  146 bits (368), Expect = 1e-33
 Identities = 71/189 (37%), Positives = 125/189 (66%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TDA   +  GK+ LKVP ++   +DG + +++ AKD+IL++IG +   GA YK+
Sbjct: 129 ATGVGSTDAAIAMLTGKIWLKVPESIAVKVDGTLKNHVTAKDVILEVIGRLGSDGANYKA 188

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF+GS VE+++++ +M L NM VE G K  +IP D  T ++L+ +    +E ++ D++A
Sbjct: 189 VEFLGSAVEAMSLDSKMVLANMSVEMGAKVAMIPTDGRTSEWLKERVG-HFEGIWPDEEA 247

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + + Y F   +++P V+ P+S D  A   E +  +++ V+IGSC+GG+ EDF+ A+++ 
Sbjct: 248 NYSAFYEFPAEEIKPNVSLPNSVDRVAPVEEVEGEEVDLVFIGSCSGGRFEDFLLASRIM 307

Query: 543 LASGGKKVK 569
               G+K+K
Sbjct: 308 ---RGRKLK 313

[222][TOP]
>UniRef100_B2UYH6 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum E3 str. Alaska E43 RepID=LEUC_CLOBA
          Length = 419

 Score =  146 bits (368), Expect = 1e-33
 Identities = 76/189 (40%), Positives = 110/189 (58%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  G+   KVP  ++F++  +   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGQTWFKVPSAIKFILKNKPAKWVSGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL+  T   ++   +D+ A
Sbjct: 196 MEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDDKTVEYLKEHTEKEWKIYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++ L+P V+ PH PDN         V I++V IGSCT G+  D   A  + 
Sbjct: 256 EYDEVIEIDLSTLKPTVSFPHLPDNTRTIDNANRVNIDQVVIGSCTNGRISDLRIARGIL 315

Query: 543 LASGGKKVK 569
               GKKVK
Sbjct: 316 ---KGKKVK 321

[223][TOP]
>UniRef100_A0RMG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           fetus subsp. fetus 82-40 RepID=LEUC_CAMFF
          Length = 421

 Score =  146 bits (368), Expect = 1e-33
 Identities = 81/198 (40%), Positives = 122/198 (61%), Gaps = 4/198 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  + +  GK   KVP T++    G+   ++  KDLIL++I +I V GA YK+
Sbjct: 135 STGMGSTDLAYAMITGKNWFKVPATIKVEFVGKPAKHIYGKDLILEVIRQIGVDGALYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKT--SVPYESVYSDQ 356
           +EF G  ++ L+M+ R +LCNM +EAGGK+G+I  D +T ++LE K   S P +  YSD+
Sbjct: 195 LEFCGDAMKYLDMDSRFSLCNMAIEAGGKSGIIAVDDITKEFLESKNLRSKP-KFHYSDE 253

Query: 357 QARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRVYIGSCTGGKTEDFMAA 530
            A +    R DV+KL+P++A P  P N     E    D+KI++V+IGSCT G+  D   A
Sbjct: 254 GANYEQVLRIDVSKLDPVIAYPFLPSNGKSINEALKDDLKIDQVFIGSCTNGRLSDLRIA 313

Query: 531 AKVFLASGGKKVKVPTFL 584
           A++     GK+V   T L
Sbjct: 314 ARIL---KGKRVAKHTRL 328

[224][TOP]
>UniRef100_B0MIU0 Putative uncharacterized protein n=1 Tax=Anaerostipes caccae DSM
           14662 RepID=B0MIU0_9FIRM
          Length = 414

 Score =  145 bits (367), Expect = 2e-33
 Identities = 73/188 (38%), Positives = 119/188 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ++GIG T+   +LG G++ ++VP T++ V+DG++PD + +KD+IL++IG++   GATYK+
Sbjct: 134 SSGIGYTEMASILGTGEMWVRVPETIKVVIDGKLPDNVSSKDIILRLIGDLGADGATYKA 193

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF GSTVE +++  RMT+ NM +EAG K  +  PD  T +Y E + S   + +Y D+ A
Sbjct: 194 LEFSGSTVEEMSVASRMTISNMAIEAGAKAALFAPDEKTAEYSEVELS-DVDWIYGDEDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +     +    L P+VA P   D      E +  ++++++IGSCT G+ ED  AAA++ 
Sbjct: 253 EYCRTVVYKAEDLVPVVACPSQVDKIKPVSEVEGTELDQIFIGSCTNGRLEDLKAAAEIL 312

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 313 ---DGKKV 317

[225][TOP]
>UniRef100_A6NUW5 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6NUW5_9BACE
          Length = 422

 Score =  145 bits (367), Expect = 2e-33
 Identities = 74/188 (39%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G    KVP  ++  + G+   Y+  KD++L +IG+I V GA YKS
Sbjct: 136 STGVGSTDMAAGMATGLAWFKVPSAIKVTLKGKFQPYVSGKDVMLHLIGQIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V+ L M++R T+ NM +EAGGKNG+ P D VT  YL G+ +  +E+  +D  A
Sbjct: 196 LEFGGEGVKELAMDDRFTISNMAIEAGGKNGIFPVDDVTRAYLNGRVTREWEAFEADPDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +  E   D+ +L P VA PH P N     + + + I +V IGSCT G+ +D   AA++ 
Sbjct: 256 VYEREVVIDLDQLRPTVALPHLPSNTRTVDQVEGMPIQQVVIGSCTNGRLKDIKEAAEIL 315

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 316 ---KGRKV 320

[226][TOP]
>UniRef100_A7H0L8 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           curvus 525.92 RepID=LEUC_CAMC5
          Length = 421

 Score =  145 bits (367), Expect = 2e-33
 Identities = 78/197 (39%), Positives = 120/197 (60%), Gaps = 3/197 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  + +  GK   KVPPT++ V  G++  ++  KDLIL+II +I V GA YK+
Sbjct: 135 STGMGSTDLAYAMITGKNWFKVPPTIKVVFRGKLGRHVYGKDLILEIIRQIGVDGARYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKT-SVPYESVYSDQQ 359
           +EF G T+++L+M+ R ++CNM +EAGGK+G+I  D  T ++L+GK      +  YSD+ 
Sbjct: 195 LEFCGETIDALDMDGRFSMCNMAIEAGGKSGIIAVDETTREFLKGKNLRAEPKFFYSDEG 254

Query: 360 ARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRVYIGSCTGGKTEDFMAAA 533
           A +         KL+P++A P  P N    RE    D+ I++ +IGSCT G+  D   AA
Sbjct: 255 AGYERVLEIYADKLDPVIAYPFLPSNGKSVREAVKDDIAIDQAFIGSCTNGRLSDLRIAA 314

Query: 534 KVFLASGGKKVKVPTFL 584
           ++     G+KV   T L
Sbjct: 315 EIL---KGRKVSRKTRL 328

[227][TOP]
>UniRef100_C5UT24 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           botulinum E1 str. 'BoNT E Beluga' RepID=C5UT24_CLOBO
          Length = 419

 Score =  145 bits (366), Expect = 2e-33
 Identities = 76/189 (40%), Positives = 109/189 (57%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TGIG+TD    +  G+   KVP  ++F++  +   ++  KD+IL IIG I V GA YKS
Sbjct: 136 STGIGSTDMAAGMATGQTWFKVPSAIKFILKNKPAKWVSGKDIILHIIGMIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  +  L+M++R T+ NM +EAGGKNG+ P D+ T KYL+  T   ++   +D+ A
Sbjct: 196 MEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDNKTVKYLKEHTVKEWKVYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      ++  L P V+ PH PDN         V I++V IGSCT G+  D   A  + 
Sbjct: 256 EYDEVIEIELNTLRPTVSFPHLPDNTRTIDNANGVDIDQVVIGSCTNGRISDLRIARDIL 315

Query: 543 LASGGKKVK 569
               GKKVK
Sbjct: 316 ---KGKKVK 321

[228][TOP]
>UniRef100_Q30WD3 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           desulfuricans subsp. desulfuricans str. G20
           RepID=LEUC_DESDG
          Length = 418

 Score =  145 bits (366), Expect = 2e-33
 Identities = 79/188 (42%), Positives = 113/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVPP++R    G MP ++ AKDL+LQ+IG I V GA YK+
Sbjct: 136 ATGLGSTDVAGAMALGETWFKVPPSIRVSYRGTMPAHVGAKDLVLQLIGHIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V+++++E RMT+ NM +EAGGK G+ P D +T  Y   +     E + +DQ A
Sbjct: 196 LEFDGPVVDAMSVEGRMTIANMAIEAGGKCGLFPSDDLTLAYTAARGRND-EKLSADQDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +     FDV+ L P +A PH P+N     E + V+I++  IGSCT G+  D   AA V 
Sbjct: 255 VYERSLSFDVSDLAPQIACPHLPENVRPVTEVQGVQIHQAVIGSCTNGRISDLREAAAVL 314

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 315 ---RGRKV 319

[229][TOP]
>UniRef100_A9BIA6 Homoaconitate hydratase family protein n=1 Tax=Petrotoga mobilis
           SJ95 RepID=A9BIA6_PETMO
          Length = 419

 Score =  145 bits (365), Expect = 3e-33
 Identities = 68/179 (37%), Positives = 114/179 (63%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    + +GKL  KVP +++ V++G +   + +KD+ L +I  +T  GATYK+
Sbjct: 135 STGVGSTDLAIAMASGKLWFKVPQSIKIVLEGSLSKGIYSKDVALYVIKNMTANGATYKA 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  +++L++E R T+ NM VE G K G++  D     +++ +T  P++S  SD+ A
Sbjct: 195 VEFEGPVIDNLSVEARFTISNMSVEMGAKVGLMKLDEKAENWIKERTDKPFKSYESDEGA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   Y+FDV+ LEP VAKPH+ DN +   E + + I++  +G+CT G+ ED   AA +
Sbjct: 255 NYEKIYKFDVSDLEPQVAKPHAVDNVSPISEVEGIPIHQGLLGTCTNGRIEDLRIAANI 313

[230][TOP]
>UniRef100_A6TSE5 3-isopropylmalate dehydratase n=1 Tax=Alkaliphilus metalliredigens
           QYMF RepID=A6TSE5_ALKMQ
          Length = 425

 Score =  144 bits (364), Expect = 4e-33
 Identities = 67/178 (37%), Positives = 110/178 (61%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD   ++  G+L  KVP  ++  ++G++   ++AKD+IL I+ ++    A YK++
Sbjct: 133 TGVGATDLATIMLTGELWFKVPEVIKIEINGKLKSGVMAKDVILHILSKLGTDAAVYKAI 192

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           E+ G TV  +++ ERM +CNM VE G K   I PD     Y++ +T   +E + +D    
Sbjct: 193 EYTGETVAEMSIAERMVICNMAVEMGAKTSYIQPDEKIIAYVKERTGKTFEILKTDDDYE 252

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           + + Y F+V  L+P VA PHS DN     + K+VK+++V+IG+CTGG+ ED   AA++
Sbjct: 253 YAASYTFNVEDLKPQVALPHSVDNGVDIDKIKEVKVDQVFIGTCTGGRLEDIEVAARI 310

[231][TOP]
>UniRef100_C2KW91 3-isopropylmalate dehydratase n=1 Tax=Oribacterium sinus F0268
           RepID=C2KW91_9FIRM
          Length = 421

 Score =  144 bits (364), Expect = 4e-33
 Identities = 70/188 (37%), Positives = 113/188 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+L  KVP  ++ V+ G++  ++  KDLIL +IG I V GA Y+S
Sbjct: 136 STGVGSTDMAAAMATGELWFKVPTAIKVVLKGKLQKHVSGKDLILHLIGMIGVDGALYES 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V SL+M++R  +CNM +EAGGKNG+ P D  T +Y++  ++  Y    +D+ A
Sbjct: 196 IEFTGEGVASLSMDDRFAICNMAIEAGGKNGIFPVDEKTLEYIKAHSNKEYHIYEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D++ L+  VA PH P+N       + + I++  IGSCT G+  D   AA++ 
Sbjct: 256 EYDRVIEIDLSSLKSTVAFPHLPENTHEIGSFEKISIDQAVIGSCTNGRLSDIKVAAEI- 314

Query: 543 LASGGKKV 566
             + G+K+
Sbjct: 315 --ARGRKI 320

[232][TOP]
>UniRef100_B6FST2 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM
           1787 RepID=B6FST2_9CLOT
          Length = 438

 Score =  144 bits (364), Expect = 4e-33
 Identities = 74/182 (40%), Positives = 108/182 (59%), Gaps = 3/182 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+L  KVP  ++FV+ G+   Y+  KD+IL IIG+I V GA YKS
Sbjct: 149 STGVGTTDIATGMATGELWFKVPSAIKFVLTGKPGKYVSGKDIILHIIGKIGVDGALYKS 208

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEFVG  + +L+M++R T+ NM +EAG KNG+   D     Y++  +   Y+   +D+ A
Sbjct: 209 MEFVGDGIANLSMDDRFTMANMAIEAGAKNGIFIVDEKAEAYMKEHSEKEYKVYTADEDA 268

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRAL---ARECKDVKINRVYIGSCTGGKTEDFMAAA 533
            +      D++K+ P VA PH P N        E + +KI++V IGSCT G+ ED   AA
Sbjct: 269 EYDEVVEIDLSKVRPTVAFPHLPGNAKTIDEVEEMEPIKIDQVVIGSCTNGRMEDMRRAA 328

Query: 534 KV 539
            V
Sbjct: 329 AV 330

[233][TOP]
>UniRef100_C4V4K3 3-isopropylmalate dehydratase n=1 Tax=Selenomonas flueggei ATCC
           43531 RepID=C4V4K3_9FIRM
          Length = 420

 Score =  144 bits (363), Expect = 5e-33
 Identities = 72/180 (40%), Positives = 106/180 (58%), Gaps = 1/180 (0%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G+   KVP  +   + G+ P  +  KD+IL +IG I V GA YKS
Sbjct: 135 STGVGTTDLAVGIATGEAWFKVPEAINVHLTGKKPQDISGKDVILTLIGMIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  V SL+M +R+T+ NM +EAG KNG+ P D V   Y+EG+ + P+  V +D  A
Sbjct: 195 LEFTGEGVASLSMTDRLTIANMAIEAGAKNGIFPYDDVCRAYVEGRMTKPFAPVAADADA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFMAAAKV 539
           R+      D++ L P+V+ PH P+N     +    + I++V IGSCT G+ ED   AA +
Sbjct: 255 RYAQTVEIDLSALRPVVSFPHLPENTKRVMDIGAPIAIDQVVIGSCTNGRLEDMEIAASI 314

[234][TOP]
>UniRef100_C0B4V9 Putative uncharacterized protein n=1 Tax=Coprococcus comes ATCC
           27758 RepID=C0B4V9_9FIRM
          Length = 414

 Score =  144 bits (363), Expect = 5e-33
 Identities = 70/188 (37%), Positives = 117/188 (62%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ++GIG T+   +LG G + +KVP T++ V+DGE+P+ +++KD+IL++IG++   GATY++
Sbjct: 133 SSGIGYTEMASILGTGTMWIKVPETIKVVIDGELPENVMSKDIILRLIGDLRADGATYRA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G+T+E++ +  RMT+ NM +EAG K  +  PD  T +Y   + +   +S+  D  A
Sbjct: 193 LEFAGNTIENMTVASRMTMANMAIEAGAKCALFTPDEKTAEYCNIELNDYQKSLVGDPDA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            ++    +      P++A P   D      E +  +I++V+IGSCT G+ ED  AAA+V 
Sbjct: 253 TYMRTITYKAEDFVPVMALPSQVDKIRNVSEVEGTEIDQVFIGSCTNGRLEDLQAAAEVL 312

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 313 ---KGKKV 317

[235][TOP]
>UniRef100_A7B6Z9 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC
           29149 RepID=A7B6Z9_RUMGN
          Length = 425

 Score =  144 bits (363), Expect = 5e-33
 Identities = 73/182 (40%), Positives = 108/182 (59%), Gaps = 3/182 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G++  KVP  ++FV+ G+   Y+  KD+I+ IIG+I V GA YKS
Sbjct: 135 STGMGTTDIATGMATGEIWFKVPAAIQFVLTGKPGKYVSGKDIIIHIIGKIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +  L+M++R T+ NM +EAG KNG+ P D  T  YLE  +   Y+   +D+ A
Sbjct: 195 MEFTGDGIAHLSMDDRFTMANMAIEAGAKNGIFPVDEQTKAYLEEHSKKEYQIFEADEDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRVYIGSCTGGKTEDFMAAA 533
            +      D++++ P VA PH P N     E    + +KI++V IGSCT G+ ED   AA
Sbjct: 255 DYEQVVTIDLSEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQVVIGSCTNGRMEDMRKAA 314

Query: 534 KV 539
            +
Sbjct: 315 AI 316

[236][TOP]
>UniRef100_Q0AZY9 3-isopropylmalate dehydratase, large subunit n=1 Tax=Syntrophomonas
           wolfei subsp. wolfei str. Goettingen RepID=Q0AZY9_SYNWW
          Length = 416

 Score =  144 bits (362), Expect = 7e-33
 Identities = 74/189 (39%), Positives = 115/189 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    L +GKL  KVP T +FV++G++P  + +KDLIL +IG++T  GATY +
Sbjct: 133 STGVGSTDLAAGLISGKLWFKVPETFKFVLNGQLPAGVYSKDLILHLIGDVTADGATYMA 192

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
            E+VG  +  L++E R T+ NM +E G K G++  D  T  +++  ++  +  V +D  A
Sbjct: 193 AEYVGEAIAGLSVEARFTISNMAIEMGAKAGLMDADQKTLDWVKEHSTKSFTPVKADADA 252

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +     +DV++LEP VA+PH+ DN A   E     I +  IG+CT G+ ED   AA + 
Sbjct: 253 VYARVKEYDVSRLEPQVARPHTVDNVAPIGEVAGTPIQQGVIGTCTNGRMEDLRIAASIL 312

Query: 543 LASGGKKVK 569
               G+KVK
Sbjct: 313 ---KGRKVK 318

[237][TOP]
>UniRef100_C4EWE6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermanaerovibrio acidaminovorans DSM 6589
           RepID=C4EWE6_9BACT
          Length = 417

 Score =  144 bits (362), Expect = 7e-33
 Identities = 75/178 (42%), Positives = 106/178 (59%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G+TD   +   G   +KVPPT+R  ++G    ++  KD +L IIG + V GA Y+++
Sbjct: 134 TGMGSTDLAAIWALGHTWMKVPPTVRVHLEGSFKPFVGGKDAMLHIIGTLGVDGARYRAL 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  V SL+M+ RMT+ NM +E G K  +  PD  T  Y+  +    +E VY D  A 
Sbjct: 194 EFHGDGVRSLSMDGRMTMANMGIECGAKAALFVPDEATLAYVAPRARRSFEPVYPDPGAA 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           +  E    +  L PLVA P+ P N   ARE +DV+I++V+IGSCT G+ ED   AAKV
Sbjct: 254 YERELTVRLDSLPPLVACPNLPSNVRPARELRDVEIHQVFIGSCTNGRIEDLRQAAKV 311

[238][TOP]
>UniRef100_C0WAT0 3-isopropylmalate dehydratase n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WAT0_9FIRM
          Length = 418

 Score =  144 bits (362), Expect = 7e-33
 Identities = 73/179 (40%), Positives = 104/179 (58%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD G  +  G    KVP  ++ ++ G+ P  +  KD++L +IG I V GA Y+S
Sbjct: 135 ATGVGSTDLGAAMATGTCWFKVPEAIKVIITGKKPADITGKDVMLTLIGMIGVDGALYQS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G  +  L+M +R T+ NM +EAG KNG+ P D  T  Y +G+    YE V +D  A
Sbjct: 195 LEFTGDGIAELSMTDRFTMANMAIEAGAKNGIFPVDEKTKAYEQGRVE-DYEIVTADSDA 253

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +      D+T L P+VA PH P N        D+ I++V IGSCT G+ ED   AAK+
Sbjct: 254 VYKRTVTIDLTALTPVVAFPHLPGNTKAIGTFGDIPIDQVVIGSCTNGRLEDLAIAAKI 312

[239][TOP]
>UniRef100_A0B7A3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosaeta
           thermophila PT RepID=A0B7A3_METTP
          Length = 382

 Score =  144 bits (362), Expect = 7e-33
 Identities = 73/193 (37%), Positives = 114/193 (59%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD   +   G+L  +VP T+   ++G + D + AKDL L ++ E+   GA Y S+
Sbjct: 104 TGVGATDMAEIYSRGRLWFRVPETICMRLEGTLGDMVSAKDLALFVVKEMGADGANYMSV 163

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EFVG  VE L++  RMTLCNM VE G K  ++PPD     YL  +   PY  ++SD    
Sbjct: 164 EFVGGAVERLSISGRMTLCNMGVEMGAKAAIVPPDESVDAYLARRARRPYTHIHSD-PGS 222

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           +  E  +DV+ + P++A P+  DN    R+   +++++V+IG+CT G+ ED   AA++  
Sbjct: 223 YYREIEYDVSDIPPMIAAPYRVDNVHPVRDLAGIEVDQVFIGTCTNGRLEDLEMAARIV- 281

Query: 546 ASGGKKVKVPTFL 584
              GK+VK+ T +
Sbjct: 282 --KGKRVKIRTLV 292

[240][TOP]
>UniRef100_C8X2U8 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfohalobium retbaense DSM 5692
           RepID=C8X2U8_9DELT
          Length = 419

 Score =  143 bits (361), Expect = 9e-33
 Identities = 75/188 (39%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG+G+TD    +  G+   KVPPT+R  ++G++  ++  KD+IL +IG I V GA YK+
Sbjct: 136 ATGLGSTDVAGAMALGETWFKVPPTIRVDVNGDLGRFVGGKDIILHLIGTIGVDGALYKA 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           +EF G TV  L++E R+T+ NM +EAGGK G+ P D  T  YL+         + +D+ A
Sbjct: 196 LEFGGGTVRDLDLEARLTIANMAIEAGGKVGLFPADQTTLDYLQAHGRSGDTFLEADEGA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            +      D   L+P VA PH P+N    R+  D+ +++V IGSCT G+  D   AA++ 
Sbjct: 256 GYERRVAIDAASLQPQVACPHLPENVHPVRDVGDIPLDQVVIGSCTNGRISDLREAAELL 315

Query: 543 LASGGKKV 566
               GKKV
Sbjct: 316 ---KGKKV 320

[241][TOP]
>UniRef100_B7APF9 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus
           ATCC 43243 RepID=B7APF9_9BACE
          Length = 415

 Score =  143 bits (361), Expect = 9e-33
 Identities = 75/191 (39%), Positives = 119/191 (62%), Gaps = 3/191 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ++GIG T+   VLG G++ +KVP T++ V++GE+P+ + AKD+IL+++G++   GATYK+
Sbjct: 138 SSGIGYTEMAAVLGTGEMWIKVPETIKVVINGELPEGVYAKDIILRLLGDLRSDGATYKA 197

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESV---YSD 353
           +EF GSTV+++ +  RMT+ NM +EAG K  +  PD  T ++    + V Y+ V    +D
Sbjct: 198 LEFSGSTVDNMTVASRMTIANMAIEAGAKAALFAPDEKTAEF----SGVNYDDVAWLKAD 253

Query: 354 QQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAA 533
             A +     +D + L P++A P   DN     E K  KI++V+IGSCT G+ ED   AA
Sbjct: 254 ADAEYCRVMEYDASTLVPVLACPSQVDNIHPVSELKGTKIDQVFIGSCTNGRLEDIKVAA 313

Query: 534 KVFLASGGKKV 566
            +     GKK+
Sbjct: 314 DIL---RGKKI 321

[242][TOP]
>UniRef100_C6JHQ9 Putative uncharacterized protein n=1 Tax=Ruminococcus sp.
           5_1_39BFAA RepID=C6JHQ9_9FIRM
          Length = 416

 Score =  143 bits (360), Expect = 1e-32
 Identities = 74/187 (39%), Positives = 110/187 (58%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD  + +  G   + VP +++F + G++P+ + A+DLIL IIGEI   G  Y++M
Sbjct: 134 TGVGCTDFLYGMVTGTSWVLVPESVKFNLTGKLPEGVYARDLILTIIGEIGANGCNYQAM 193

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G   ++L++ +RM LCNM VEAG K G+   D    +YL+     P    +SD  A 
Sbjct: 194 EFTGEGAKTLSISDRMALCNMAVEAGAKTGIFEADEKAIEYLKEHGREPKAVYHSDPDAV 253

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           +  EY FD++K+ P+VAKP   DN   A E   ++IN  ++GSC  G+ ED    A++  
Sbjct: 254 YAREYTFDLSKVRPVVAKPDFVDNVVPAEEACGIEINEAFLGSCNNGRIEDLRVGAEII- 312

Query: 546 ASGGKKV 566
              GKKV
Sbjct: 313 --KGKKV 317

[243][TOP]
>UniRef100_C5F2A2 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           pullorum MIT 98-5489 RepID=C5F2A2_9HELI
          Length = 422

 Score =  143 bits (360), Expect = 1e-32
 Identities = 74/193 (38%), Positives = 123/193 (63%), Gaps = 5/193 (2%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD  + +  GK   K+P  ++    G+   ++  KDLIL++I +I V GA Y++
Sbjct: 135 STGMGSTDLAYAMITGKNWFKIPSAIKVEFIGKPAKHIYGKDLILEVIRQIGVDGALYQT 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSV---PYESVYSD 353
           +EF G  ++ L M++R +LCNM +EAG KNG+I PD +T ++L+ +  +   P E  YSD
Sbjct: 195 LEFCGEGIKYLGMDDRFSLCNMAIEAGAKNGIIAPDEITREFLKSRPFLRANPRE-FYSD 253

Query: 354 QQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINRVYIGSCTGGKTEDFMA 527
             A +    + D++KLEP++A P  P N +++++  K D+KI++V+IGSCT G+  D   
Sbjct: 254 ADANYTQTIQIDISKLEPVIAYPFLPSNGKSISQALKDDLKIDQVFIGSCTNGRLSDLKI 313

Query: 528 AAKVFLASGGKKV 566
           A+++     GKKV
Sbjct: 314 ASEIL---KGKKV 323

[244][TOP]
>UniRef100_C4GAI7 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4GAI7_9FIRM
          Length = 434

 Score =  143 bits (360), Expect = 1e-32
 Identities = 73/188 (38%), Positives = 111/188 (59%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  +RF + G+   Y+  KD+IL IIG I V GA Y+S
Sbjct: 150 STGVGSTDMAAGMATGQAWFKVPEAIRFKLVGKPGPYISGKDIILHIIGLIGVDGARYQS 209

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  ++ L+M++R T+ NM +E G KNG+ P D  T  Y++           +D  A
Sbjct: 210 MEFDGEGIQYLSMDDRFTIANMAIEGGAKNGIFPVDDQTLAYIKEHADRKPLVYEADADA 269

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 542
            + +EY  D++ L+P V+ PH P+N     + +D+ I++V IGSCT G+  D  AAA++ 
Sbjct: 270 DYAAEYTIDLSSLKPTVSFPHLPENTRTIDQIEDIAIDQVVIGSCTNGRLSDLKAAAEIL 329

Query: 543 LASGGKKV 566
               G+KV
Sbjct: 330 ---KGRKV 334

[245][TOP]
>UniRef100_B1C9W1 Putative uncharacterized protein n=1 Tax=Anaerofustis
           stercorihominis DSM 17244 RepID=B1C9W1_9FIRM
          Length = 424

 Score =  143 bits (360), Expect = 1e-32
 Identities = 68/179 (37%), Positives = 108/179 (60%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  ++FV+  +   ++  KD+IL IIG+I V GA Y+S
Sbjct: 136 STGVGSTDMAIGMATGEAWFKVPSAIKFVLKNKPAKWISGKDIILHIIGKIGVDGALYRS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  ++ L+M++R ++ NM +EAG KNG+ P D  T +Y +  ++  +E   +D+ A
Sbjct: 196 MEFTGDGIKYLSMDDRFSMANMAIEAGAKNGIFPVDDKTIEYAKEHSTKTFEVFEADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
           ++      D++KL P V+ PH P+N     E   V I++  IGSCT G+ ED   AA +
Sbjct: 256 QYDEVIEIDLSKLRPTVSFPHLPENTKTVDEAGKVYIDQAVIGSCTNGRLEDIKMAADI 314

[246][TOP]
>UniRef100_UPI0001979722 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI0001979722
          Length = 420

 Score =  142 bits (359), Expect = 1e-32
 Identities = 66/179 (36%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  ++F + G++  Y+  KD+IL IIG+I V GA YKS
Sbjct: 136 STGVGSTDMAVGMATGEAWFKVPKAMKFNLKGKLRPYVSGKDVILHIIGKIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L +++R+ + NM +EAG KNG+   D +T +Y +G+TS  +    +D+ A
Sbjct: 196 MEFSGEGLKNLTIDDRLCIANMAIEAGAKNGIFEVDDITIEYAKGRTSKEFRIYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   +  ++  ++  VA PH P+N     +  ++KI++V IGSCT G+  D   AA +
Sbjct: 256 EYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEIKIDQVVIGSCTNGRLSDMEVAANI 314

[247][TOP]
>UniRef100_C4Z1K2 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit n=1
           Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K2_EUBE2
          Length = 586

 Score =  142 bits (359), Expect = 1e-32
 Identities = 77/187 (41%), Positives = 109/187 (58%)
 Frame = +3

Query: 6   TGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKSM 185
           TG+G TD  + +  G   + VP TLRF + G++ D + A+DLIL IIG+I   GA YK+M
Sbjct: 304 TGVGCTDYLYAMVTGTSWVMVPGTLRFNLKGKLNDGVYARDLILSIIGKIGANGANYKAM 363

Query: 186 EFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQAR 365
           EF G  + SL+M +R+++CN+ VEAG K  ++  D V   YL+     P     SD  A 
Sbjct: 364 EFAGEGLHSLSMADRISICNLCVEAGAKTALMEVDDVAMDYLKEHGREPKACFTSDDDAV 423

Query: 366 FLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFL 545
           F   Y  D++ ++P+VAKPH  DN   A+E   VKI+  ++GSC  G+ ED    A +  
Sbjct: 424 FEQVYDIDLSTIQPIVAKPHFVDNVVPAKESLGVKIDEAFLGSCNNGRIEDLRVGAAII- 482

Query: 546 ASGGKKV 566
              GKKV
Sbjct: 483 --KGKKV 487

[248][TOP]
>UniRef100_C3XG48 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XG48_9HELI
          Length = 420

 Score =  142 bits (359), Expect = 1e-32
 Identities = 66/179 (36%), Positives = 110/179 (61%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G+TD    +  G+   KVP  ++F + G++  Y+  KD+IL IIG+I V GA YKS
Sbjct: 136 STGVGSTDMAVGMATGEAWFKVPKAMKFNLKGKLRPYVSGKDVILHIIGKIGVDGALYKS 195

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +++L +++R+ + NM +EAG KNG+   D +T +Y +G+TS  +    +D+ A
Sbjct: 196 MEFSGEGLKNLTIDDRLCIANMAIEAGAKNGIFEVDDITIEYAKGRTSKEFRIYKADEDA 255

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKV 539
            +   +  ++  ++  VA PH P+N     +  ++KI++V IGSCT G+  D   AA +
Sbjct: 256 EYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEIKIDQVVIGSCTNGRLSDMEVAANI 314

[249][TOP]
>UniRef100_B5CQV8 Putative uncharacterized protein n=1 Tax=Ruminococcus lactaris ATCC
           29176 RepID=B5CQV8_9FIRM
          Length = 424

 Score =  142 bits (359), Expect = 1e-32
 Identities = 73/182 (40%), Positives = 105/182 (57%), Gaps = 3/182 (1%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           +TG+G TD    +  G++  KVP  ++FV+ G+   Y+  KD+I+ IIG+I V GA YKS
Sbjct: 135 STGMGTTDVATGMATGEIWFKVPSAIKFVLTGKPSKYVSGKDIIIHIIGQIGVDGALYKS 194

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 362
           MEF G  +  L+M++R T+ NM +EAG KNG+ P D  T  YL       Y    +D+ A
Sbjct: 195 MEFTGDGIACLSMDDRFTMANMAIEAGAKNGIFPVDEKTKAYLAEHCKKEYTVYEADEDA 254

Query: 363 RFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRVYIGSCTGGKTEDFMAAA 533
            +      D++K+ P VA PH P N     E    + +KI++V IGSCT G+ ED   AA
Sbjct: 255 VYDEVIEIDLSKVRPTVAFPHLPGNAKTIDEVEAMEPIKIDQVVIGSCTNGRMEDLRKAA 314

Query: 534 KV 539
            +
Sbjct: 315 AI 316

[250][TOP]
>UniRef100_C7P908 3-isopropylmalate dehydratase n=1 Tax=Methanocaldococcus fervens
           AG86 RepID=C7P908_METFA
          Length = 420

 Score =  142 bits (359), Expect = 1e-32
 Identities = 76/195 (38%), Positives = 112/195 (57%), Gaps = 9/195 (4%)
 Frame = +3

Query: 3   ATGIGNTDAGFVLGAGKLLLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEITVAGATYKS 182
           ATG G TD  ++   G+  +KVP T+R  + G+  + + AKD++L++  EI   GATY +
Sbjct: 130 ATGFGATDMAYIYATGEAWIKVPKTIRVDIVGKNEN-ISAKDIVLRVCKEIGRRGATYMA 188

Query: 183 MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESV------ 344
           +E+ G  V+ +NM+ R+TLCNM +E GGK GVI  D +TY YL+ +  +  E +      
Sbjct: 189 IEYGGEVVKRMNMDGRLTLCNMAIEMGGKTGVIEADEITYNYLKNERGLSDEKIAELKKE 248

Query: 345 ---YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTE 515
               +  +A +  E   D+T +E  VA PH PDN     E +  +IN+V+IGSCT G+  
Sbjct: 249 RITVNKDEANYYREIEIDITDMEEQVAVPHHPDNVKPVSEVEGTEINQVFIGSCTNGRLS 308

Query: 516 DFMAAAKVFLASGGK 560
           D   AAK     GGK
Sbjct: 309 DLREAAKYL--KGGK 321