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[1][TOP]
>UniRef100_B9SQS5 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS5_RICCO
          Length = 510

 Score =  362 bits (930), Expect = 9e-99
 Identities = 175/190 (92%), Positives = 183/190 (96%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KTSVP+E VYSD++ARFLSEYRFDV+KLEPLVAKPHSPDN ALARECKDV
Sbjct: 308 DSTTFKYLEDKTSVPFEPVYSDEKARFLSEYRFDVSKLEPLVAKPHSPDNCALARECKDV 367

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDFMAAAKVFLASG KKVKVPTFLVPATQKVWMDVYSLPVPGSGG
Sbjct: 368 KIDRVYIGSCTGGKTEDFMAAAKVFLASG-KKVKVPTFLVPATQKVWMDVYSLPVPGSGG 426

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 427 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPMVCVSTTNRNFPGRMGHKEGQIY 486

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 487 LASPYTAAAS 496

[2][TOP]
>UniRef100_UPI0001983BAD PREDICTED: similar to Os02g0125100 n=1 Tax=Vitis vinifera
           RepID=UPI0001983BAD
          Length = 508

 Score =  362 bits (928), Expect = 1e-98
 Identities = 174/190 (91%), Positives = 182/190 (95%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KT VPYE VYSD+QARFLSEYRFDV+KLEPLVAKPHSPDNRALARECKDV
Sbjct: 306 DSTTHKYLEDKTDVPYEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDV 365

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVF ASG KKVKVPTFLVPATQKVWMDVYSLPVPG GG
Sbjct: 366 KIDRVYIGSCTGGKTEDFLAAAKVFHASG-KKVKVPTFLVPATQKVWMDVYSLPVPGCGG 424

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASPSCGACLGGP+DTYARMNEPQVCVSTTNRNFPGRMGH+EG+IY
Sbjct: 425 KTCSQIFEEAGCDTPASPSCGACLGGPRDTYARMNEPQVCVSTTNRNFPGRMGHKEGQIY 484

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 485 LASPYTAAAS 494

[3][TOP]
>UniRef100_C5XT62 Putative uncharacterized protein Sb04g002120 n=1 Tax=Sorghum
           bicolor RepID=C5XT62_SORBI
          Length = 507

 Score =  359 bits (921), Expect = 1e-97
 Identities = 171/190 (90%), Positives = 181/190 (95%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+KYLEGKTSV YE VYSD QARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDV
Sbjct: 305 DETTFKYLEGKTSVDYEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDV 364

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           K++RVYIGSCTGGKTEDF+AAAKVFLASG KKVKVPTFLVPATQKVWMDVYSLPVPGSGG
Sbjct: 365 KVDRVYIGSCTGGKTEDFLAAAKVFLASG-KKVKVPTFLVPATQKVWMDVYSLPVPGSGG 423

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASPSCGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 424 KTCSQIFEEAGCDTPASPSCGACLGGPRDTYARMNEPMVCVSTTNRNFPGRMGHKEGQIY 483

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 484 LASPYTAAAS 493

[4][TOP]
>UniRef100_B9SQS6 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS6_RICCO
          Length = 621

 Score =  358 bits (918), Expect = 2e-97
 Identities = 170/190 (89%), Positives = 181/190 (95%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KTSVPYE VYSD+QARFLSEYRFD++KLEPLVAKPHSPDNRALARECKDV
Sbjct: 419 DSTTFKYLEDKTSVPYEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDNRALARECKDV 478

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF AAAKVFLASG KKVKVPTFLVPATQKVWMDVYS+PVPGSGG
Sbjct: 479 KIDRVYIGSCTGGKTEDFTAAAKVFLASG-KKVKVPTFLVPATQKVWMDVYSIPVPGSGG 537

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCS+IFEEAGCDTPASP C AC+GGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 538 KTCSRIFEEAGCDTPASPGCSACMGGPRDTYARMNEPMVCVSTTNRNFPGRMGHKEGQIY 597

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 598 LASPYTAAAS 607

[5][TOP]
>UniRef100_B9HSU8 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HSU8_POPTR
          Length = 462

 Score =  358 bits (918), Expect = 2e-97
 Identities = 170/190 (89%), Positives = 182/190 (95%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KT++PYE VYSD QARFLSEYRFD++KLEPLVAKPHSPDNRALAREC+DV
Sbjct: 260 DSTTFKYLEDKTTLPYEPVYSDAQARFLSEYRFDISKLEPLVAKPHSPDNRALARECRDV 319

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDFMA AKVFLASG KKVKVPTFLVPATQKVWMDVY+LPVPGSGG
Sbjct: 320 KIDRVYIGSCTGGKTEDFMAVAKVFLASG-KKVKVPTFLVPATQKVWMDVYTLPVPGSGG 378

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC+QIFEEAGCDTPASPSCGACLGGPKDT+ARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 379 KTCAQIFEEAGCDTPASPSCGACLGGPKDTHARMNEPMVCVSTTNRNFPGRMGHKEGQIY 438

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 439 LASPYTAAAS 448

[6][TOP]
>UniRef100_B9HKV5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HKV5_POPTR
          Length = 443

 Score =  357 bits (915), Expect = 5e-97
 Identities = 169/191 (88%), Positives = 183/191 (95%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PDS T+KYLE KTS+PYE VYSD QARFL+EYRFDVTKLEPLVAKPHSPDNRALARECKD
Sbjct: 240 PDSTTFKYLEDKTSLPYEPVYSDAQARFLTEYRFDVTKLEPLVAKPHSPDNRALARECKD 299

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           VKI+RVYIGSCTGGKTEDFMAAAKVFLASG KKV+VPTFLVPAT KVWMD+Y+LPVPGSG
Sbjct: 300 VKIDRVYIGSCTGGKTEDFMAAAKVFLASG-KKVRVPTFLVPATGKVWMDLYTLPVPGSG 358

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           GKTCSQIFEEAGCDTPA+P+CGAC+GGP+DTYARMN+P VCVSTTNRNFPGRMGH+EG+I
Sbjct: 359 GKTCSQIFEEAGCDTPANPTCGACMGGPRDTYARMNKPVVCVSTTNRNFPGRMGHKEGQI 418

Query: 541 YLVSPYTAAAS 573
           YL SPYTAAAS
Sbjct: 419 YLASPYTAAAS 429

[7][TOP]
>UniRef100_B4FG11 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B4FG11_MAIZE
          Length = 505

 Score =  353 bits (907), Expect = 4e-96
 Identities = 168/190 (88%), Positives = 180/190 (94%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+KYLEGKTSV YE VYSD QARF S+YRFDV+KLEP+VAKPHSPDNRA ARECKDV
Sbjct: 303 DETTFKYLEGKTSVDYEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDV 362

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVFLASG KKVKVPTFLVPATQKVW+D+YSLPVPGSGG
Sbjct: 363 KIDRVYIGSCTGGKTEDFLAAAKVFLASG-KKVKVPTFLVPATQKVWLDIYSLPVPGSGG 421

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASP+CGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 422 KTCSQIFEEAGCDTPASPNCGACLGGPRDTYARMNEPTVCVSTTNRNFPGRMGHKEGQIY 481

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 482 LASPYTAAAS 491

[8][TOP]
>UniRef100_C4JBG7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4JBG7_MAIZE
          Length = 505

 Score =  353 bits (906), Expect = 5e-96
 Identities = 167/190 (87%), Positives = 181/190 (95%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+KYLEG+TSV Y+ VYSD +ARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDV
Sbjct: 303 DETTFKYLEGRTSVDYQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDV 362

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVFLASG KKVKVPTFLVPATQKVWMDVYSLPVPGSGG
Sbjct: 363 KIDRVYIGSCTGGKTEDFLAAAKVFLASG-KKVKVPTFLVPATQKVWMDVYSLPVPGSGG 421

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC+QIFEEAGCDTPASP+CGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 422 KTCAQIFEEAGCDTPASPNCGACLGGPRDTYARMNEPTVCVSTTNRNFPGRMGHKEGQIY 481

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 482 LASPYTAAAS 491

[9][TOP]
>UniRef100_B6TYJ6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6TYJ6_MAIZE
          Length = 492

 Score =  353 bits (906), Expect = 5e-96
 Identities = 167/190 (87%), Positives = 181/190 (95%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+KYLEG+TSV Y+ VYSD +ARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDV
Sbjct: 303 DETTFKYLEGRTSVDYQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDV 362

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVFLASG KKVKVPTFLVPATQKVWMDVYSLPVPGSGG
Sbjct: 363 KIDRVYIGSCTGGKTEDFLAAAKVFLASG-KKVKVPTFLVPATQKVWMDVYSLPVPGSGG 421

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC+QIFEEAGCDTPASP+CGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 422 KTCAQIFEEAGCDTPASPNCGACLGGPRDTYARMNEPTVCVSTTNRNFPGRMGHKEGQIY 481

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 482 LASPYTAAAS 491

[10][TOP]
>UniRef100_Q6Z702 Os02g0125100 protein n=2 Tax=Oryza sativa RepID=Q6Z702_ORYSJ
          Length = 514

 Score =  353 bits (905), Expect = 7e-96
 Identities = 166/190 (87%), Positives = 180/190 (94%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+ YLEGKTSV YE VYSD QARF+S+YRFDV+KLEP++AKPHSPDNRALARECKDV
Sbjct: 312 DQTTFNYLEGKTSVEYEPVYSDAQARFVSDYRFDVSKLEPVIAKPHSPDNRALARECKDV 371

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF AAAKVFLASG KKVKVPTFLVPATQKVWMD+YS+PVPG+GG
Sbjct: 372 KIDRVYIGSCTGGKTEDFFAAAKVFLASG-KKVKVPTFLVPATQKVWMDIYSIPVPGAGG 430

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASPSCGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 431 KTCSQIFEEAGCDTPASPSCGACLGGPRDTYARMNEPMVCVSTTNRNFPGRMGHKEGQIY 490

Query: 544 LVSPYTAAAS 573
           L SP+TAAAS
Sbjct: 491 LASPFTAAAS 500

[11][TOP]
>UniRef100_B6U6T6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6U6T6_MAIZE
          Length = 504

 Score =  353 bits (905), Expect = 7e-96
 Identities = 168/190 (88%), Positives = 180/190 (94%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+KYLEGKTSV YE VYSD QARF S+YRFDV+KLEP+VAKPHSPDNRA ARECKDV
Sbjct: 302 DETTFKYLEGKTSVDYEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDV 361

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAK+FLASG KKVKVPTFLVPATQKVW+DVYSLPVPGSGG
Sbjct: 362 KIDRVYIGSCTGGKTEDFLAAAKLFLASG-KKVKVPTFLVPATQKVWLDVYSLPVPGSGG 420

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASP+CGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 421 KTCSQIFEEAGCDTPASPNCGACLGGPRDTYARMNEPTVCVSTTNRNFPGRMGHKEGQIY 480

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 481 LASPYTAAAS 490

[12][TOP]
>UniRef100_UPI0001983576 PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI0001983576
          Length = 508

 Score =  352 bits (903), Expect = 1e-95
 Identities = 168/190 (88%), Positives = 180/190 (94%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KTS+PYE VYSD+QARFLSEYRFD++KLEPLVAKPHSPD  ALARECKDV
Sbjct: 306 DSTTHKYLEDKTSLPYEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDKCALARECKDV 365

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVF ASG KKVKVPTFLVPATQKVWMDVYSLPVPG GG
Sbjct: 366 KIDRVYIGSCTGGKTEDFLAAAKVFHASG-KKVKVPTFLVPATQKVWMDVYSLPVPGCGG 424

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPASP+CGAC+GGP+DTYARMNEPQVCVSTTNRNFPGRMGH+E +IY
Sbjct: 425 KTCSQIFEEAGCDTPASPTCGACMGGPRDTYARMNEPQVCVSTTNRNFPGRMGHKESQIY 484

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 485 LASPYTAAAS 494

[13][TOP]
>UniRef100_C4IZQ5 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4IZQ5_MAIZE
          Length = 505

 Score =  352 bits (902), Expect = 2e-95
 Identities = 166/190 (87%), Positives = 180/190 (94%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+KYLEG+TSV Y+ VYSD +ARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDV
Sbjct: 303 DETTFKYLEGRTSVDYQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDV 362

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AA KVFLASG KKVKVPTFLVPATQKVWMDVYSLPVPGSGG
Sbjct: 363 KIDRVYIGSCTGGKTEDFLAAVKVFLASG-KKVKVPTFLVPATQKVWMDVYSLPVPGSGG 421

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC+QIFEEAGCDTPASP+CGACLGGP+DTYARMNEP VCVSTTNRNFPGRMGH+EG+IY
Sbjct: 422 KTCAQIFEEAGCDTPASPNCGACLGGPRDTYARMNEPTVCVSTTNRNFPGRMGHKEGQIY 481

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 482 LASPYTAAAS 491

[14][TOP]
>UniRef100_Q94AR8 3-isopropylmalate dehydratase n=1 Tax=Arabidopsis thaliana
           RepID=LEUC_ARATH
          Length = 509

 Score =  342 bits (876), Expect = 2e-92
 Identities = 160/191 (83%), Positives = 179/191 (93%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD+ T  Y+E +TSVP+E VYSD  A F+++YRFDV+KLEP+VAKPHSPDNRALARECKD
Sbjct: 306 PDATTLNYVENRTSVPFEPVYSDGNASFVADYRFDVSKLEPVVAKPHSPDNRALARECKD 365

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           VKI+RVYIGSCTGGKTEDFMAAAK+F A+G +KVKVPTFLVPATQKVWMDVY+LPVPG+G
Sbjct: 366 VKIDRVYIGSCTGGKTEDFMAAAKLFHAAG-RKVKVPTFLVPATQKVWMDVYALPVPGAG 424

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           GKTC+QIFEEAGCDTPASPSCGACLGGP DTYAR+NEPQVCVSTTNRNFPGRMGH+EG+I
Sbjct: 425 GKTCAQIFEEAGCDTPASPSCGACLGGPADTYARLNEPQVCVSTTNRNFPGRMGHKEGQI 484

Query: 541 YLVSPYTAAAS 573
           YL SPYTAAAS
Sbjct: 485 YLASPYTAAAS 495

[15][TOP]
>UniRef100_B8LQ24 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQ24_PICSI
          Length = 516

 Score =  335 bits (858), Expect = 2e-90
 Identities = 155/190 (81%), Positives = 176/190 (92%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT+ YLEGKTS  +E++YSD+ AR+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +
Sbjct: 315 DQITFDYLEGKTSSSFEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHI 374

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDFMAAAK+ + S G+KVKVPTFLVPATQKVWMD+Y+LPVPG  G
Sbjct: 375 KIDRVYIGSCTGGKTEDFMAAAKIMI-SAGQKVKVPTFLVPATQKVWMDLYTLPVPGGNG 433

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTCSQIFEEAGCDTPA+P+CGACLGGP+DTYARMN PQVCVSTTN+NFPGRMGH+EG+IY
Sbjct: 434 KTCSQIFEEAGCDTPANPNCGACLGGPRDTYARMNVPQVCVSTTNKNFPGRMGHKEGQIY 493

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 494 LASPYTAAAS 503

[16][TOP]
>UniRef100_C0PRG9 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=C0PRG9_PICSI
          Length = 237

 Score =  334 bits (857), Expect = 3e-90
 Identities = 156/190 (82%), Positives = 175/190 (92%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+ YLEGKTS  +E++YSD+ AR+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +
Sbjct: 36  DQTTFDYLEGKTSSSFEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHI 95

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDFMAAAK+ L S G+KVKVPTFLVPATQKVWMD+Y+LPVPG  G
Sbjct: 96  KIDRVYIGSCTGGKTEDFMAAAKI-LISAGQKVKVPTFLVPATQKVWMDLYTLPVPGGNG 154

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC+QIFEEAGCDTPASP+CGACLGGP+DTYARMN PQVCVSTTNRNFPGRMGH+EG+IY
Sbjct: 155 KTCAQIFEEAGCDTPASPNCGACLGGPRDTYARMNVPQVCVSTTNRNFPGRMGHKEGQIY 214

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 215 LASPYTAAAS 224

[17][TOP]
>UniRef100_B8LQY6 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQY6_PICSI
          Length = 515

 Score =  334 bits (857), Expect = 3e-90
 Identities = 156/190 (82%), Positives = 175/190 (92%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+ YLEGKTS  +E++YSD+ AR+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +
Sbjct: 314 DQTTFDYLEGKTSSSFEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHI 373

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDFMAAAK+ L S G+KVKVPTFLVPATQKVWMD+Y+LPVPG  G
Sbjct: 374 KIDRVYIGSCTGGKTEDFMAAAKI-LISAGQKVKVPTFLVPATQKVWMDLYTLPVPGGNG 432

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC+QIFEEAGCDTPASP+CGACLGGP+DTYARMN PQVCVSTTNRNFPGRMGH+EG+IY
Sbjct: 433 KTCAQIFEEAGCDTPASPNCGACLGGPRDTYARMNVPQVCVSTTNRNFPGRMGHKEGQIY 492

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 493 LASPYTAAAS 502

[18][TOP]
>UniRef100_A9TGU1 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9TGU1_PHYPA
          Length = 518

 Score =  328 bits (840), Expect = 2e-88
 Identities = 155/190 (81%), Positives = 173/190 (91%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+ T KYLEGKTS PY+   SD  A FL EYRFDV+KLEPLVAKPHSPDNR LARECKDV
Sbjct: 317 DATTAKYLEGKTSKPYQVFTSDGNASFLQEYRFDVSKLEPLVAKPHSPDNRGLARECKDV 376

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAA++ LA  G+KVKVPTFLVPATQKVWMD+YSLPVPG+ G
Sbjct: 377 KIDRVYIGSCTGGKTEDFLAAAEL-LAISGQKVKVPTFLVPATQKVWMDLYSLPVPGTDG 435

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KTC++IF++AGCDTPASPSC ACLGGP+DTYARMN+PQVCVSTTNRNFPGRMGH+EG+IY
Sbjct: 436 KTCAEIFQQAGCDTPASPSCAACLGGPRDTYARMNDPQVCVSTTNRNFPGRMGHKEGQIY 495

Query: 544 LVSPYTAAAS 573
           L SPYTAAAS
Sbjct: 496 LASPYTAAAS 505

[19][TOP]
>UniRef100_A7QRJ3 Chromosome chr8 scaffold_150, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7QRJ3_VITVI
          Length = 424

 Score =  301 bits (772), Expect = 2e-80
 Identities = 146/166 (87%), Positives = 154/166 (92%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KT VPYE VYSD+QARFLSEYRFDV+KLEPLVAKPHSPDNRALARECKDV
Sbjct: 260 DSTTHKYLEDKTDVPYEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDV 319

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVF AS GKKVKVPTFLVPATQKVWMDVYSLPVPG GG
Sbjct: 320 KIDRVYIGSCTGGKTEDFLAAAKVFHAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGCGG 378

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNR 501
           KTCSQIFEEAGCDTPASPSCGACLGGP+DTYARMNEPQ  +   N+
Sbjct: 379 KTCSQIFEEAGCDTPASPSCGACLGGPRDTYARMNEPQASMRLYNK 424

[20][TOP]
>UniRef100_A5AN38 Putative uncharacterized protein n=1 Tax=Vitis vinifera
           RepID=A5AN38_VITVI
          Length = 252

 Score =  297 bits (760), Expect = 4e-79
 Identities = 161/233 (69%), Positives = 169/233 (72%), Gaps = 50/233 (21%)
 Frame = +1

Query: 25  LEGKTSVPYE--SVYSDQQARFLSEYRFDVTKLEPLVAK---------------PHSPDN 153
           LEGK   P+   S+  D   RFLSEYRFDV+KLEPLVAK               PHSPDN
Sbjct: 8   LEGKRR-PFTKASLRRDSVHRFLSEYRFDVSKLEPLVAKVRDFYMALSEIIFIFPHSPDN 66

Query: 154 RALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDV 333
           RALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF  SG KKVKVPTFLVPATQKVWMDV
Sbjct: 67  RALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVFHVSG-KKVKVPTFLVPATQKVWMDV 125

Query: 334 YSLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQ------------ 477
           YSLPVPG GGKTCSQIFEEAGCDTPASPSCGACLGGP+DTYARMNEPQ            
Sbjct: 126 YSLPVPGCGGKTCSQIFEEAGCDTPASPSCGACLGGPRDTYARMNEPQATFGCGWIPFFF 185

Query: 478 ---------------------VCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
                                VCVSTTNRNFPGRMGH+EG+IYL SPYTAAAS
Sbjct: 186 GHGGCMINYLMILDLLYLHLKVCVSTTNRNFPGRMGHKEGQIYLASPYTAAAS 238

[21][TOP]
>UniRef100_A8JG03 Isopropylmalate dehydratase, large subunit n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8JG03_CHLRE
          Length = 487

 Score =  293 bits (751), Expect = 5e-78
 Identities = 134/191 (70%), Positives = 165/191 (86%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+ Y++ +T   +E VYSD  A ++++Y++DV+KLEPLVA PHSPDNR  AREC D
Sbjct: 285 PDQTTFDYVKARTQEAFEPVYSDGAASYIADYKWDVSKLEPLVAAPHSPDNRKTARECSD 344

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           VKI+RVYIGSCTGGKTEDF++AAK+F  +  ++VKVPT+LVPATQKVW DVY++PVPG  
Sbjct: 345 VKIDRVYIGSCTGGKTEDFISAAKLFYRAK-RQVKVPTYLVPATQKVWADVYTMPVPGCD 403

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           GKT ++IFEE+GC TPA+PSC ACLGGP+DT+ARMNEP+VCVSTTNRNFPGRMGH+EG+I
Sbjct: 404 GKTAAEIFEESGCITPAAPSCAACLGGPRDTFARMNEPEVCVSTTNRNFPGRMGHKEGQI 463

Query: 541 YLVSPYTAAAS 573
           YL SPYTAAAS
Sbjct: 464 YLASPYTAAAS 474

[22][TOP]
>UniRef100_A7NXJ3 Chromosome chr5 scaffold_2, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7NXJ3_VITVI
          Length = 507

 Score =  293 bits (749), Expect = 8e-78
 Identities = 140/158 (88%), Positives = 150/158 (94%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS T+KYLE KTS+PYE VYSD+QARFLSEYRFD++KLEPLVAKPHSPD  ALARECKDV
Sbjct: 323 DSTTHKYLEDKTSLPYEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDKCALARECKDV 382

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+RVYIGSCTGGKTEDF+AAAKVF AS GKKVKVPTFLVPATQKVWMDVYSLPVPG GG
Sbjct: 383 KIDRVYIGSCTGGKTEDFLAAAKVFHAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGCGG 441

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQ 477
           KTCSQIFEEAGCDTPASP+CGAC+GGP+DTYARMNEPQ
Sbjct: 442 KTCSQIFEEAGCDTPASPTCGACMGGPRDTYARMNEPQ 479

[23][TOP]
>UniRef100_Q111B2 Homoaconitate hydratase family protein n=1 Tax=Trichodesmium
           erythraeum IMS101 RepID=Q111B2_TRIEI
          Length = 439

 Score =  259 bits (663), Expect = 8e-68
 Identities = 122/191 (63%), Positives = 154/191 (80%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD +T++YL G+T  P+ES YSD+ A F S+  +DVTKLEP+VAKPHSPDN+ LAR C+D
Sbjct: 242 PDEMTFEYLRGRTDKPFESFYSDKNAEFYSDRSYDVTKLEPVVAKPHSPDNKELARNCQD 301

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           VKI+RVYIGSCTGGKT DF+ AAK+       +VKVPT+LVPATQKV+ D++ +      
Sbjct: 302 VKIDRVYIGSCTGGKTSDFLHAAKLI---KDHQVKVPTYLVPATQKVYEDLFIIK---HD 355

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           GKT S+IF +AGC  PA+PSC ACLGGPKDT+ R+NEP++CVSTTNRNFPGRMG+++ ++
Sbjct: 356 GKTLSEIFLDAGCIEPAAPSCAACLGGPKDTFGRLNEPEICVSTTNRNFPGRMGNKQAQV 415

Query: 541 YLVSPYTAAAS 573
           YL SPYTAAAS
Sbjct: 416 YLASPYTAAAS 426

[24][TOP]
>UniRef100_C0Z3H8 AT4G13430 protein n=1 Tax=Arabidopsis thaliana RepID=C0Z3H8_ARATH
          Length = 175

 Score =  244 bits (623), Expect = 3e-63
 Identities = 114/128 (89%), Positives = 124/128 (96%)
 Frame = +1

Query: 190 NRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKT 369
           +RVYIGSCTGGKTEDFMAAAK+F A+G +KVKVPTFLVPATQKVWMDVY+LPVPG+GGKT
Sbjct: 35  DRVYIGSCTGGKTEDFMAAAKLFHAAG-RKVKVPTFLVPATQKVWMDVYALPVPGAGGKT 93

Query: 370 CSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLV 549
           C+QIFEEAGCDTPASPSCGACLGGP DTYAR+NEPQVCVSTTNRNFPGRMGH+EG+IYL 
Sbjct: 94  CAQIFEEAGCDTPASPSCGACLGGPADTYARLNEPQVCVSTTNRNFPGRMGHKEGQIYLA 153

Query: 550 SPYTAAAS 573
           SPYTAAAS
Sbjct: 154 SPYTAAAS 161

[25][TOP]
>UniRef100_C4C1N1 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Sebaldella termitidis
           ATCC 33386 RepID=C4C1N1_9FUSO
          Length = 435

 Score =  202 bits (515), Expect = 1e-50
 Identities = 99/191 (51%), Positives = 135/191 (70%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT +Y+  KT  P+E +YSD+ A + +EY+++  ++EP+VAKP +P N  LA+   D
Sbjct: 235 PDEITVEYVTEKTDKPFELIYSDKDADYSAEYKYNANEMEPIVAKPFNPGNTDLAKNLGD 294

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           VK++R YIGSCTGGKT DF+AAAK+     G+KV + TF+VP+T KV   +  + +    
Sbjct: 295 VKLDRAYIGSCTGGKTTDFVAAAKIL---KGRKVAIETFIVPSTVKVEEALSKIII---D 348

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           G+TC +IFE+AGC     PSC ACLGGP DT+ R +  +V +STTNRNFPGRMG  + ++
Sbjct: 349 GETCMEIFEKAGCKI-GPPSCAACLGGPVDTFGRTHANEVVISTTNRNFPGRMGSMDSQV 407

Query: 541 YLVSPYTAAAS 573
           YL SPYTAAAS
Sbjct: 408 YLASPYTAAAS 418

[26][TOP]
>UniRef100_A1BES2 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides DSM 266 RepID=A1BES2_CHLPD
          Length = 431

 Score =  196 bits (499), Expect = 8e-49
 Identities = 106/190 (55%), Positives = 124/190 (65%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+IT  Y+  +T  PYE   SD  AR+ S Y ++V +LEP+VA PHSPDNRA  R  +  
Sbjct: 236 DAITEAYVNARTQKPYELFRSDPDARYHSSYTYNVRELEPVVACPHSPDNRATVRSVQGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            I R YIGSCTGGK  DFM AAK+     GKKV VPT +VPAT KV  D   L +    G
Sbjct: 296 AITRSYIGSCTGGKLSDFMMAAKIL---NGKKVSVPTNIVPATVKVAAD---LAIEQYEG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +T  QIFE+AGC   A PSC ACLGGP DT  R  +  V VSTTNRNFPGRMG ++  +Y
Sbjct: 350 RTLKQIFEDAGCSI-ALPSCAACLGGPSDTVGRSVDNDVVVSTTNRNFPGRMGSKKAGVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[27][TOP]
>UniRef100_A4SFC8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeovibrioides DSM 265 RepID=A4SFC8_PROVI
          Length = 431

 Score =  193 bits (490), Expect = 9e-48
 Identities = 102/190 (53%), Positives = 125/190 (65%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  +++ KTS PYE   SD  A + S+ R++ +++EP+VAKPHSPDNRA  +  K  
Sbjct: 236 DEITEAFVKSKTSKPYEIFTSDPGAAYFSKTRYNASEMEPVVAKPHSPDNRATVQSMKGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI + YIGSCTGGK  DF  AAK+     GK+V VPT +VPAT KV    + L      G
Sbjct: 296 KITKSYIGSCTGGKLADFKLAAKIL---SGKRVSVPTNIVPATVKV---AHDLETELYNG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           K+   IFE+AGC   A PSC ACLGGP DT  R  +  V VSTTNRNFPGRMG ++ E+Y
Sbjct: 350 KSLKSIFEDAGCSI-ALPSCAACLGGPTDTVGRSVDRDVVVSTTNRNFPGRMGSKQAEVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[28][TOP]
>UniRef100_B4SDL0 Homoaconitate hydratase family protein n=1 Tax=Pelodictyon
           phaeoclathratiforme BU-1 RepID=B4SDL0_PELPB
          Length = 431

 Score =  192 bits (487), Expect = 2e-47
 Identities = 105/190 (55%), Positives = 124/190 (65%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DSI   Y++ ++  PYE   SD  AR+ S+YR+DV  LEP+VA+PHSPDNRA  R  +  
Sbjct: 236 DSIAENYVKARSQKPYELFQSDPDARYHSKYRYDVRTLEPVVAQPHSPDNRATVRSVQGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI + YIGSCTGGK  DFM AAK+     G KV V T +VPAT KV  D   L      G
Sbjct: 296 KITKSYIGSCTGGKLTDFMMAAKIL---KGHKVSVTTNIVPATVKVARD---LECELYDG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           ++  QIFE+AGC T A PSC ACLGGP DT  R  +  V VSTTNRNFPGRMG +   +Y
Sbjct: 350 QSLKQIFEDAGC-TIALPSCAACLGGPADTVGRSVDNDVVVSTTNRNFPGRMGSKHAGVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[29][TOP]
>UniRef100_Q3APC5 3-isopropylmalate dehydratase n=1 Tax=Chlorobium chlorochromatii
           CaD3 RepID=Q3APC5_CHLCH
          Length = 431

 Score =  189 bits (480), Expect = 1e-46
 Identities = 102/190 (53%), Positives = 123/190 (64%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+I  +Y++ +T  PYE   SD  A++ S YR++V  LEP+VA+PHSPDNRA  R     
Sbjct: 236 DNIAEEYVKARTKKPYEIFQSDPDAKYHSTYRYNVRDLEPVVAQPHSPDNRATVRSVAGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI + YIGSCTGGK  DFM AAK+     G+KV V T +VPAT  V     SL      G
Sbjct: 296 KITKSYIGSCTGGKLSDFMMAAKIL---KGQKVTVTTTIVPATTLV---ARSLETEQYDG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           K+  QIFEEAGC+  A PSC ACLGGP DT  R  +  + VSTTNRNFPGRMG +   +Y
Sbjct: 350 KSLKQIFEEAGCNV-ALPSCAACLGGPADTVGRSVDNDLVVSTTNRNFPGRMGSKHAGVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[30][TOP]
>UniRef100_C1ZRL8 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Rhodothermus marinus
           DSM 4252 RepID=C1ZRL8_RHOMR
          Length = 432

 Score =  187 bits (476), Expect = 4e-46
 Identities = 95/191 (49%), Positives = 125/191 (65%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y+  +T  P+E  +SD  AR+ SEY +DV+KLEP+VAKPH PDNRA   E   
Sbjct: 235 PDEKTIAYVRERTDAPFEIYHSDPDARYHSEYVYDVSKLEPVVAKPHRPDNRATVTEVAG 294

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
            K++R YIGSCTGGK EDF+AAA++     G++V++ TF+VPA+  V   ++   +    
Sbjct: 295 TKLDRAYIGSCTGGKLEDFIAAARIL---KGQEVRIDTFVVPASTYVEQQLHHYKI---D 348

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           G +   IF  AGC      SCGACLGGP DT+ R +  +V +STTNRNFPGRMG ++  +
Sbjct: 349 GVSLYDIFVNAGCKI-GHASCGACLGGPPDTFGRTHGTEVVISTTNRNFPGRMGSKQASV 407

Query: 541 YLVSPYTAAAS 573
           YL SP T AAS
Sbjct: 408 YLASPLTVAAS 418

[31][TOP]
>UniRef100_Q3B597 3-isopropylmalate dehydratase n=1 Tax=Chlorobium luteolum DSM 273
           RepID=Q3B597_PELLD
          Length = 431

 Score =  187 bits (475), Expect = 5e-46
 Identities = 101/190 (53%), Positives = 123/190 (64%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  +++ +T+  YE  +SD  A++ S YR+D +KLEP+VAKPHSPDNRA  R     
Sbjct: 236 DEITEAFVKARTTKSYEIFHSDPDAKYHSLYRYDASKLEPVVAKPHSPDNRATVRSVAGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            I + YIGSCTGGK  DF  AA++     G+KV V T +VPAT +V  D   L      G
Sbjct: 296 PITKSYIGSCTGGKLTDFKMAARIL---NGRKVAVTTNIVPATVQVARD---LEQEMHEG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KT  QIF EAGC+  A PSC ACLGGP DT  R  +  + VSTTNRNFPGRMG +  E+Y
Sbjct: 350 KTLKQIFMEAGCNI-ALPSCAACLGGPADTVGRSVDRDIVVSTTNRNFPGRMGSKNAEVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[32][TOP]
>UniRef100_B3EHN8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium limicola
           DSM 245 RepID=B3EHN8_CHLL2
          Length = 431

 Score =  187 bits (475), Expect = 5e-46
 Identities = 101/190 (53%), Positives = 124/190 (65%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D++T  Y++  +S PYE   SD  A + S YR++  +LEP+VAKPHSPDNRA  R  +  
Sbjct: 236 DAVTEAYVKAHSSKPYEIFQSDPDADYHSVYRYNARELEPVVAKPHSPDNRATVRSMQGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI + YIGSCTGGK  DFM AAK+     GK+V VPT +VPAT  V     +L      G
Sbjct: 296 KITKSYIGSCTGGKLTDFMLAAKIL---KGKQVTVPTNIVPATVLV---ARALECETWEG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
            T  +IFE+AGC   A PSC ACLGGP DT  R  +  V VSTTNRNFPGRMG ++ ++Y
Sbjct: 350 VTLKKIFEDAGCSI-ALPSCAACLGGPADTVGRSADQDVVVSTTNRNFPGRMGSKKADVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[33][TOP]
>UniRef100_UPI00016C35D3 homoaconitate hydratase family protein n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C35D3
          Length = 435

 Score =  183 bits (465), Expect = 7e-45
 Identities = 95/192 (49%), Positives = 124/192 (64%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSV--PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 177
           D +T  Y+  + +   PY  V SD  A+F+ E  +DV+KLEP++AKPHSPDN+A   + K
Sbjct: 237 DQVTLDYVNKRNAGNRPYTVVKSDPGAQFVFEKVYDVSKLEPVIAKPHSPDNKAFVSQVK 296

Query: 178 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGS 357
             K++R YIGSCTGGK  DF AAA++     GK VK+ TF+VPAT +V      L     
Sbjct: 297 GTKLDRAYIGSCTGGKLTDFKAAAQLL---NGKTVKIDTFVVPATTEV---ARGLDTETI 350

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
           GG++   IF  AG       SC ACLGGP DT+ R+N P  C+STTNRNFPGRMGH++ +
Sbjct: 351 GGRSLRDIFLSAGAKI-GDASCAACLGGPSDTFGRLNAPISCISTTNRNFPGRMGHKDAQ 409

Query: 538 IYLVSPYTAAAS 573
           ++L SP T AAS
Sbjct: 410 VFLASPLTVAAS 421

[34][TOP]
>UniRef100_B4S6N0 Homoaconitate hydratase family protein n=1 Tax=Prosthecochloris
           aestuarii DSM 271 RepID=B4S6N0_PROA2
          Length = 432

 Score =  183 bits (465), Expect = 7e-45
 Identities = 95/190 (50%), Positives = 125/190 (65%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y++ +TS PYE  +SD  A + S Y ++V +LEP+VA+PHSPDNRA  R  +  
Sbjct: 236 DEVTEAYVKARTSKPYEIFHSDPDAIYHSIYHYNVEELEPVVAQPHSPDNRATVRSVQGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           +I + YIGSCTGGK  DF  AAK+     G++V + T +VPAT +V     SL      G
Sbjct: 296 RITKSYIGSCTGGKLSDFKMAAKIL---NGQQVSIQTNIVPATVEV---AKSLETEQYEG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           K+  ++ E+AGC T A PSC ACLGGP DT+ R  +  + VSTTNRNFPGRMG ++  +Y
Sbjct: 350 KSIRKVLEDAGC-TIAQPSCAACLGGPADTFGRSEDNDLVVSTTNRNFPGRMGSKKAGVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[35][TOP]
>UniRef100_Q8KER8 3-isopropylmalate dehydratase, large subunit, putative n=1
           Tax=Chlorobaculum tepidum RepID=Q8KER8_CHLTE
          Length = 431

 Score =  182 bits (463), Expect = 1e-44
 Identities = 100/190 (52%), Positives = 120/190 (63%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D++T  +++ +TS PYE   SD  A++ S YR++V K+EP+VAKPHSPDNRA        
Sbjct: 236 DAVTEAFVKARTSKPYEIFTSDPDAQYHSMYRYNVEKMEPIVAKPHSPDNRATVHSVAGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            I + YIGSCTGGK  DF  AAK+     GKKV V T +VPAT  V      L      G
Sbjct: 296 PITKSYIGSCTGGKLTDFKLAAKIL---KGKKVAVTTNIVPATVLV---ASQLETEMYDG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +T   IFEEAGC+  A PSC ACLGGP DT  R  +  V VSTTNRNFPGRMG +   +Y
Sbjct: 350 QTLRHIFEEAGCNI-ALPSCAACLGGPSDTVGRSVDNDVVVSTTNRNFPGRMGSKFASVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[36][TOP]
>UniRef100_B3QM97 Homoaconitate hydratase family protein n=1 Tax=Chlorobaculum parvum
           NCIB 8327 RepID=B3QM97_CHLP8
          Length = 431

 Score =  182 bits (462), Expect = 2e-44
 Identities = 101/190 (53%), Positives = 121/190 (63%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D++T  +++ +TS PYE   SD  A++ S YR++V KLEP+VA+PHSPDNRA  R     
Sbjct: 236 DAVTEAFVKARTSKPYEIFQSDPDAQYHSMYRYNVEKLEPVVAQPHSPDNRATVRSVAGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            I + YIGSCTGGK  DF  AAK+     GKKV V T +VPAT  V      L      G
Sbjct: 296 PITKSYIGSCTGGKITDFRLAAKIL---KGKKVAVTTNIVPATVLV---ASQLENEMYDG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +T   IFEEAGC+  A PSC ACLGGP DT  R  +  V VSTTNRNFPGRMG +   +Y
Sbjct: 350 QTLRHIFEEAGCNI-ALPSCAACLGGPSDTVGRSVDNDVVVSTTNRNFPGRMGSKMAGVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[37][TOP]
>UniRef100_Q0YQD5 Homoaconitate hydratase family protein:3-isopropylmalate
           dehydratase, prokaryotic n=1 Tax=Chlorobium ferrooxidans
           DSM 13031 RepID=Q0YQD5_9CHLB
          Length = 431

 Score =  182 bits (462), Expect = 2e-44
 Identities = 98/190 (51%), Positives = 120/190 (63%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DS+   Y+  ++  PYE   SD  A++ S Y ++V +LEP+VA+PHSPDNRA  R  +  
Sbjct: 236 DSVAESYVRARSQKPYEIFRSDPDAKYHSRYHYNVRELEPVVAQPHSPDNRATVRSVQGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI + YIGSCTGGK  DF+ AAK+     GKKV V T +VPAT  V     +L      G
Sbjct: 296 KITKSYIGSCTGGKLTDFVMAAKIL---KGKKVSVTTNIVPATVLV---ARALETERFEG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
            T  QIFE+AGC   A PSC ACLGGP DT  R  +  + VSTTNRNFPGRMG +   +Y
Sbjct: 350 VTLKQIFEDAGCSI-ALPSCAACLGGPSDTVGRSVDNDLVVSTTNRNFPGRMGSKHAGVY 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[38][TOP]
>UniRef100_B3QSN7 Homoaconitate hydratase family protein n=1 Tax=Chloroherpeton
           thalassium ATCC 35110 RepID=B3QSN7_CHLT3
          Length = 431

 Score =  181 bits (460), Expect = 3e-44
 Identities = 94/190 (49%), Positives = 121/190 (63%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  +++ +TS PYE  +SD  A++ S Y ++V +LEP+VAKPHSPDNR   R     
Sbjct: 236 DEITEAFVKARTSAPYEIFHSDPDAKYFSTYHYNVEELEPVVAKPHSPDNRDTVRNVAGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           K+ + Y+GSCTGGK  DF  AAKV     G+ VKVPTF+VP +  V   +    +    G
Sbjct: 296 KLTKCYLGSCTGGKLTDFEFAAKVL---HGQTVKVPTFVVPGSTLVAKQLTEKTI---DG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
            T  +IFE+AGC   A  SC ACLGGP DT  R ++    +STTNRNFPGRMG ++ E+Y
Sbjct: 350 MTYMEIFEKAGC-IIAESSCAACLGGPADTVGRSSDGDTVISTTNRNFPGRMGSKKSEVY 408

Query: 544 LVSPYTAAAS 573
           L SP T AAS
Sbjct: 409 LASPLTVAAS 418

[39][TOP]
>UniRef100_B2VKF3 3-isopropylmalate dehydratase large subunit n=1 Tax=Erwinia
           tasmaniensis RepID=B2VKF3_ERWT9
          Length = 436

 Score =  174 bits (440), Expect = 6e-42
 Identities = 89/191 (46%), Positives = 120/191 (62%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           P+  T  YL  +T +P+  V  D  AR+      +VT+++PLVAKPHSPDN       K+
Sbjct: 235 PNQATLDYLATRTDIPFSVVEPDADARYSQVLDINVTEMQPLVAKPHSPDNVVAIDTLKN 294

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V I++ YIGSCTGGK  DF+AAA+V     G+KV VPTF VPAT++V+  + S  +    
Sbjct: 295 VAISQAYIGSCTGGKLADFIAAARVI---KGRKVVVPTFAVPATKEVFHGLISTDI---D 348

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
           G++  +I  +AG    +   C AC GGP DT+ R+N+P   +STTNRNF GRMGH+   I
Sbjct: 349 GQSVYRILCDAGVQLSSESGCAACCGGPADTFGRVNQPISVISTTNRNFVGRMGHKRANI 408

Query: 541 YLVSPYTAAAS 573
           YL SPY  AA+
Sbjct: 409 YLASPYAVAAA 419

[40][TOP]
>UniRef100_B3EKV4 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides BS1 RepID=B3EKV4_CHLPB
          Length = 432

 Score =  172 bits (437), Expect = 1e-41
 Identities = 97/190 (51%), Positives = 119/190 (62%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           DSIT  Y++ ++  PYE   SD  A + S +R+   +LEP+VA PHSPDNRA  R  +  
Sbjct: 236 DSITEAYVKERSDKPYEIFTSDPDALYHSIHRYKTEELEPVVAMPHSPDNRATVRSVQGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI + YIGSCTGGK  DF+ AAKV     G  V VPT +VPAT +V     SL      G
Sbjct: 296 KITKSYIGSCTGGKLIDFVMAAKVL---KGNTVSVPTNIVPATVEV---AQSLTTEEFDG 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +    I +EAGC T A PSC ACLGGP DT+ R  +  + VSTTNRNFPGRMG ++  + 
Sbjct: 350 QPIITILKEAGC-TIAPPSCAACLGGPSDTFGRSVDNDLVVSTTNRNFPGRMGSKKAGVC 408

Query: 544 LVSPYTAAAS 573
           L SP TAAAS
Sbjct: 409 LASPLTAAAS 418

[41][TOP]
>UniRef100_B3E0P6 3-isopropylmalate dehydratase large subunit n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3E0P6_METI4
          Length = 455

 Score =  167 bits (424), Expect = 4e-40
 Identities = 84/190 (44%), Positives = 116/190 (61%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +  K L+  T   +E V  D+   F + Y  D++ +EP VA PH+P NR  A+E   V
Sbjct: 259 DFVRQKVLKNGTKKEFEVVDPDKDQHFFASYFIDLSLVEPTVAAPHNPGNRMKAKELGSV 318

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI+R Y+GSCTGGK  DF+A A +      + V V TF VP+T +V   ++ + + G   
Sbjct: 319 KIDRAYLGSCTGGKLSDFIAFASILK---NRTVSVETFAVPSTPEVVDQLHKIEIEG--- 372

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           K+      EAG     +PSC ACLGGP DT+ R+N+P VC+S+TNRNFPGRMG +  ++Y
Sbjct: 373 KSIWDTLREAGVQITENPSCAACLGGPMDTFGRVNKPLVCISSTNRNFPGRMGDKSSQVY 432

Query: 544 LVSPYTAAAS 573
           L SP T A+S
Sbjct: 433 LASPLTVASS 442

[42][TOP]
>UniRef100_B4D0Q5 Aconitate hydratase domain protein n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0Q5_9BACT
          Length = 456

 Score =  167 bits (423), Expect = 5e-40
 Identities = 90/182 (49%), Positives = 111/182 (60%)
 Frame = +1

Query: 28  EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 207
           E  T   +E    DQ  +F+ +  FD++KLEP VA    P  R  A+E   V ++R YIG
Sbjct: 267 ENGTKSTFEPAEIDQDQKFIYDKVFDLSKLEPTVACHPDPGQRKTAKELAGVSLDRAYIG 326

Query: 208 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 387
           SCTGGKT DF+A A+V     GK VK+ TF VPAT KV   V  L      G++   I E
Sbjct: 327 SCTGGKTSDFLAFARVVK---GKSVKIDTFGVPATTKV---VQELKDTQWDGQSVWNILE 380

Query: 388 EAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAA 567
            AG     + SC ACLGGP DT+ RMN P  C+S TNRNFPGRMGH+E +++L SPYT A
Sbjct: 381 SAGVRMTENASCAACLGGPVDTFGRMNTPLKCISATNRNFPGRMGHKESQVFLASPYTVA 440

Query: 568 AS 573
           AS
Sbjct: 441 AS 442

[43][TOP]
>UniRef100_A9PBQ8 Putative uncharacterized protein n=1 Tax=Populus trichocarpa
           RepID=A9PBQ8_POPTR
          Length = 97

 Score =  165 bits (417), Expect = 3e-39
 Identities = 72/83 (86%), Positives = 81/83 (97%)
 Frame = +1

Query: 325 MDVYSLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRN 504
           MD+Y+LPVPGSGGKTCSQIFEEAGCDTPA+P+CGAC+GGP+DTYARMN+P VCVSTTNRN
Sbjct: 1   MDLYTLPVPGSGGKTCSQIFEEAGCDTPANPTCGACMGGPRDTYARMNKPVVCVSTTNRN 60

Query: 505 FPGRMGHREGEIYLVSPYTAAAS 573
           FPGRMGH+EG+IYL SPYTAAAS
Sbjct: 61  FPGRMGHKEGQIYLASPYTAAAS 83

[44][TOP]
>UniRef100_A6DRT0 3-isopropylmalate dehydratase n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DRT0_9BACT
          Length = 433

 Score =  163 bits (413), Expect = 8e-39
 Identities = 88/190 (46%), Positives = 116/190 (61%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+    Y++ +T VPY    +D  A +   Y  + ++LEP VA P +PD R    E    
Sbjct: 236 DAKVEAYVKERTDVPYTLFKADADADYKDVYEINCSELEPTVAIPSAPDKRKGVSEIAGT 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            + R YIGSCTGGKTEDF AAA++     G+KV + TF+VP+T  V  D+ +L       
Sbjct: 296 DLTRAYIGSCTGGKTEDFAAAAEIMY---GQKVAMDTFVVPSTTFVEKDLNTLKFKD--- 349

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           KT  +IF EAGC     P C ACLGGP+DT+ R +  ++ VSTTNRNFPGRMG  + ++Y
Sbjct: 350 KTYMEIFLEAGCRI-GPPGCAACLGGPEDTFGRTHAEEIVVSTTNRNFPGRMGSMQAKVY 408

Query: 544 LVSPYTAAAS 573
           L SPY AAAS
Sbjct: 409 LASPYVAAAS 418

[45][TOP]
>UniRef100_B9XBH0 Aconitate hydratase domain protein n=1 Tax=bacterium Ellin514
           RepID=B9XBH0_9BACT
          Length = 455

 Score =  161 bits (408), Expect = 3e-38
 Identities = 87/188 (46%), Positives = 113/188 (60%)
 Frame = +1

Query: 10  ITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKI 189
           + Y+     T   Y+ V  D   +F+ +   D++KLEP VA    P  R  A+E  DVK+
Sbjct: 261 VDYRCKLNGTKATYQPVERDANEKFVYDMVVDLSKLEPTVACHPDPGQRKKAKEM-DVKL 319

Query: 190 NRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKT 369
           +R YIGSCTGGKT DF+  A+V     GK+V + TF VPAT ++   V+ L     G KT
Sbjct: 320 DRAYIGSCTGGKTSDFLEFARVLK---GKRVMIDTFGVPATPEI---VHDLQTARWGEKT 373

Query: 370 CSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLV 549
             QI  +AG     +  C ACLGGP DT+ RMN P  C+S TNRNFPGRMGH+E +++L 
Sbjct: 374 VWQILVDAGVQMTENAGCAACLGGPVDTFGRMNTPMKCISATNRNFPGRMGHKESQVFLA 433

Query: 550 SPYTAAAS 573
           SP T AAS
Sbjct: 434 SPATVAAS 441

[46][TOP]
>UniRef100_Q6B920 3-isopropylmalate dehydratase large subunit n=1 Tax=Gracilaria
           tenuistipitata var. liui RepID=Q6B920_GRATL
          Length = 439

 Score =  155 bits (391), Expect = 3e-36
 Identities = 79/192 (41%), Positives = 115/192 (59%), Gaps = 1/192 (0%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVP-YESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 177
           P++ T +Y+  ++ +  ++ +  DQ A +     +DVT ++P +AKPHSPDN       +
Sbjct: 239 PNNSTIEYINARSDIKDFDIIVPDQSAHYTKVLEYDVTNIQPQIAKPHSPDNVDSIDNVE 298

Query: 178 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGS 357
             KI+R YIGSCTGGK+ DF AAAK+       KV + TF VPAT++V+ D+ +  +   
Sbjct: 299 GEKIDRAYIGSCTGGKSSDFYAAAKIL---KNHKVSIDTFGVPATREVFYDIINQKIDDI 355

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
              +  +I   AG      PSC AC GGP DT+ R+N     +STTNRNF GRMG +  +
Sbjct: 356 ---SVYEILVNAGVHMTTEPSCAACCGGPIDTFGRVNNTMSVISTTNRNFSGRMGAKSAQ 412

Query: 538 IYLVSPYTAAAS 573
           IYL SPY+ A++
Sbjct: 413 IYLGSPYSVAST 424

[47][TOP]
>UniRef100_B3TAM8 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8G2 RepID=B3TAM8_9ARCH
          Length = 423

 Score =  151 bits (381), Expect = 4e-35
 Identities = 83/191 (43%), Positives = 111/191 (58%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD   + YL  +    Y++VY D  A++   Y +DVT+LEPLVAKP SP N ++ +E   
Sbjct: 236 PDQKVFDYLSERGVTEYDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTG 295

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           +++++ YIGSCTG K ED  A AK+     GKKVK+ T ++PA   ++            
Sbjct: 296 IELDKSYIGSCTGAKYEDLEAVAKIL---KGKKVKIRTEILPAAISIYKKATE------- 345

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
               +QIF +AG      P+CGAC G      A+    +VCVSTTNRNFPGRMGH E + 
Sbjct: 346 -NGLTQIFIDAGA-VVGPPTCGACCGAHMGVLAK---DEVCVSTTNRNFPGRMGHVESKT 400

Query: 541 YLVSPYTAAAS 573
           YL SP  AAAS
Sbjct: 401 YLTSPLVAAAS 411

[48][TOP]
>UniRef100_B3T9D1 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG6J21 RepID=B3T9D1_9ARCH
          Length = 423

 Score =  151 bits (381), Expect = 4e-35
 Identities = 83/191 (43%), Positives = 111/191 (58%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD   + YL  +    Y++VY D  A++   Y +DVT+LEPLVAKP SP N ++ +E   
Sbjct: 236 PDQKVFDYLSERGVTEYDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTG 295

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           +++++ YIGSCTG K ED  A AK+     GKKVK+ T ++PA   ++            
Sbjct: 296 IELDKSYIGSCTGAKYEDLEAVAKIL---KGKKVKIRTEILPAAISIYKKATE------- 345

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
               +QIF +AG      P+CGAC G      A+    +VCVSTTNRNFPGRMGH E + 
Sbjct: 346 -NGLTQIFIDAGA-VVGPPTCGACCGAHMGVLAK---DEVCVSTTNRNFPGRMGHVESKT 400

Query: 541 YLVSPYTAAAS 573
           YL SP  AAAS
Sbjct: 401 YLTSPLVAAAS 411

[49][TOP]
>UniRef100_B3T8D2 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG5E24 RepID=B3T8D2_9ARCH
          Length = 423

 Score =  151 bits (381), Expect = 4e-35
 Identities = 83/191 (43%), Positives = 111/191 (58%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD   + YL  +    Y++VY D  A++   Y +DVT+LEPLVAKP SP N ++ +E   
Sbjct: 236 PDQKVFDYLSERGVTEYDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTG 295

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           +++++ YIGSCTG K ED  A AK+     GKKVK+ T ++PA   ++            
Sbjct: 296 IELDKSYIGSCTGAKYEDLEAVAKIL---KGKKVKIRTEILPAAISIYKKATE------- 345

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
               +QIF +AG      P+CGAC G      A+    +VCVSTTNRNFPGRMGH E + 
Sbjct: 346 -NGLTQIFIDAGA-VVGPPTCGACCGAHMGVLAK---DEVCVSTTNRNFPGRMGHVESKT 400

Query: 541 YLVSPYTAAAS 573
           YL SP  AAAS
Sbjct: 401 YLTSPLVAAAS 411

[50][TOP]
>UniRef100_B3TBB7 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8O8 RepID=B3TBB7_9ARCH
          Length = 423

 Score =  149 bits (375), Expect = 2e-34
 Identities = 81/191 (42%), Positives = 114/191 (59%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD   + YL  +    Y++VY D+ A++   Y +DV++LEPLVAKP SP N ++ +E   
Sbjct: 236 PDQKVFDYLAERGVTEYDAVYDDEDAQYAKTYEYDVSELEPLVAKPFSPQNVSVVQETTG 295

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           ++I++ YIGSCTG K ED +A A++     G+KVKV T +VPA   ++          + 
Sbjct: 296 IEIDKSYIGSCTGAKYEDLVAVARIL---KGRKVKVRTEVVPAAISIYKK--------AS 344

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +IF +AG     +P+CGAC G      A+    +VCVSTTNRNFPGRMGH + + 
Sbjct: 345 ENGLDKIFLDAGA-VIGAPTCGACCGAHMGVLAK---DEVCVSTTNRNFPGRMGHVDSKT 400

Query: 541 YLVSPYTAAAS 573
           YL SP  AAAS
Sbjct: 401 YLTSPLVAAAS 411

[51][TOP]
>UniRef100_C9RAX0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ammonifex
           degensii KC4 RepID=C9RAX0_9THEO
          Length = 421

 Score =  139 bits (349), Expect = 2e-31
 Identities = 84/193 (43%), Positives = 109/193 (56%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  YLEG+   PY+   SD  AR+ + Y FDV++LEP VA PHSP N     E   
Sbjct: 229 PDEKTAAYLEGRARRPYKFFQSDPDARYQAVYEFDVSRLEPQVALPHSPANTRPVTEVTH 288

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           + I++V IGSCT G+ ED   AA+V     GKKV   V   ++P TQ+++          
Sbjct: 289 ITIDQVVIGSCTNGRLEDLRVAAQVL---KGKKVHPYVRLIVIPGTQEIYRQALR----- 340

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF EAG    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E 
Sbjct: 341 ---EGLIEIFLEAG-GAVSTPTCGPCLGGHMGVLAK---GERAVATTNRNFVGRMGHPES 393

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 394 EVYLASPAVAAAS 406

[52][TOP]
>UniRef100_A4J182 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum reducens MI-1 RepID=A4J182_DESRM
          Length = 418

 Score =  138 bits (347), Expect = 3e-31
 Identities = 79/193 (40%), Positives = 110/193 (56%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT +Y+EG+T  PY    SD  A++   Y FDV K+EP VA PH P+N     +   
Sbjct: 228 PDEITRQYVEGRTKRPYTFYTSDPDAQYSKVYEFDVNKIEPQVAFPHLPENARPVSQAGH 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           V I++  IGSCT G+ ED   AA++     GKKV  +V   ++P TQ+++          
Sbjct: 288 VDIDQAVIGSCTNGRMEDLRLAAEIL---KGKKVHQQVRLIVIPGTQEIYRQAMR----- 339

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AG    ++P+CG CLGG     A+    + C++TTNRNF GRMGH E 
Sbjct: 340 ---EGLFEIFLDAGA-VVSTPTCGPCLGGHMGILAK---GERCIATTNRNFVGRMGHAES 392

Query: 535 EIYLVSPYTAAAS 573
           E+YL +P  AAAS
Sbjct: 393 EVYLANPAVAAAS 405

[53][TOP]
>UniRef100_A9A5B7 3-isopropylmalate dehydratase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A5B7_NITMS
          Length = 422

 Score =  135 bits (341), Expect = 2e-30
 Identities = 78/190 (41%), Positives = 109/190 (57%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D     YL  + +   +    D  A++ + Y ++ +++EPLVAKP SP+N A+ RE   V
Sbjct: 236 DQKVVDYLSSRGATNAQVFKGDDDAQYANVYEYEASEMEPLVAKPFSPENIAVVREAPSV 295

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           ++++ YIGSCTG K ED  AAAK+     GK VK+ T ++PA+    + +Y   +     
Sbjct: 296 ELDKSYIGSCTGAKYEDLEAAAKIL---KGKTVKIRTEILPAS----ISIYKRAMENG-- 346

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
                IF +AG  T   P+CGAC G      A+    ++C+STTNRNFPGRMGH E E Y
Sbjct: 347 --LLTIFLDAGV-TVGPPTCGACCGAHMGVLAK---NEICISTTNRNFPGRMGHVESETY 400

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 401 LSSPMVAAAS 410

[54][TOP]
>UniRef100_C7GFH7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Roseburia
           intestinalis L1-82 RepID=C7GFH7_9FIRM
          Length = 420

 Score =  134 bits (338), Expect = 4e-30
 Identities = 79/192 (41%), Positives = 109/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D++  +Y+E  +  PY    +D+ A +   Y  D++ L+P VA PH P+N     E  D+
Sbjct: 231 DNLAKEYMEAHSKRPYVVYEADEDAEYEETYTIDLSTLKPTVAFPHLPENTKTIDEVGDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ +D   AA +     GKKV   +   ++PATQK+++D         
Sbjct: 291 KIDQVVIGSCTNGRMDDLRVAASIL---KGKKVAKGLRVIVIPATQKIYLDAME------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAG    ++P+CG CLGG     A   E + CVSTTNRNF GRMGH E E
Sbjct: 342 --EGLLKTFIEAGA-VVSTPTCGPCLGGYMGILA---EHERCVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           IYL SP  AAAS
Sbjct: 396 IYLASPAVAAAS 407

[55][TOP]
>UniRef100_C1TNL5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNL5_9BACT
          Length = 419

 Score =  134 bits (337), Expect = 5e-30
 Identities = 83/193 (43%), Positives = 104/193 (53%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y E + S P+ + Y D+   +      DV KL PLVA PHSPDN   A    D
Sbjct: 228 PDETTLAYAEARASRPFTARYPDEGCEYAKRVEIDVEKLTPLVAAPHSPDNVRPASTFGD 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
            +I +V+IGSCT G+ ED  AAA V     GKKV   V   ++PA+ +V+          
Sbjct: 288 TEIQQVFIGSCTNGRLEDMAAAASVL---EGKKVHPSVRCIVIPASYEVYNACLE----- 339

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              K   + F EAG     +P+CG CLGG     A   E + CVST+NRNF GRMGH + 
Sbjct: 340 ---KGYIRTFTEAGA-AVCTPTCGPCLGGHMGILA---EGERCVSTSNRNFVGRMGHPKS 392

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP TAA S
Sbjct: 393 EVYLASPVTAAWS 405

[56][TOP]
>UniRef100_A0RXN9 3-isopropylmalate dehydratase large subunit n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RXN9_CENSY
          Length = 429

 Score =  134 bits (337), Expect = 5e-30
 Identities = 74/190 (38%), Positives = 109/190 (57%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T  YL  + +   + V  D  A +   + ++ +++EPLVAKP+SP+N ++ RE   V
Sbjct: 242 DKKTAGYLSSRGATGIKPVIGDDDAEYSEVFEYEGSEMEPLVAKPYSPENVSIVREAPSV 301

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           ++++ YIGSCTG K ED  AAA++     G+KV++ T ++PA   ++       + G   
Sbjct: 302 ELDKAYIGSCTGAKMEDLEAAARIL---KGRKVRIRTEVLPAAISIYRKAVERGLVG--- 355

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
                IF +AG  T   P+CGAC G        + + +VC+STTNRNFPGRMG  E + Y
Sbjct: 356 -----IFLDAGA-TVGPPTCGACCGAHMGV---LGKGEVCISTTNRNFPGRMGDIESQTY 406

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 407 LASPLVAAAS 416

[57][TOP]
>UniRef100_Q8PZT3 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina mazei RepID=LEUC1_METMA
          Length = 391

 Score =  134 bits (336), Expect = 6e-30
 Identities = 79/191 (41%), Positives = 107/191 (56%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+ +L+ +   PYE VYSD  A +L E+ +D   +EP VA PH  DN     E + 
Sbjct: 205 PDEKTFDFLKNRAVAPYEPVYSDPDASYLKEFVYDAGDIEPQVACPHQVDNVKPVGEVEG 264

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++V+IG+CT G+ ED   AA V     GKKV V T ++PA++   +           
Sbjct: 265 THVDQVFIGTCTNGRLEDLEVAASVL---KGKKVTVRTIIIPASRSTLLAAIK------- 314

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +I  +AG  T A+P CG CLG  +     + E +VCVST NRNF GRMG ++G I
Sbjct: 315 -NGTMEILLKAGV-TLATPGCGPCLGAHQGV---LGEGEVCVSTANRNFKGRMG-KDGFI 368

Query: 541 YLVSPYTAAAS 573
           YL SP TAAAS
Sbjct: 369 YLASPATAAAS 379

[58][TOP]
>UniRef100_A5D4W1 3-isopropylmalate dehydratase large subunit n=1 Tax=Pelotomaculum
           thermopropionicum SI RepID=A5D4W1_PELTS
          Length = 420

 Score =  132 bits (333), Expect = 1e-29
 Identities = 78/193 (40%), Positives = 107/193 (55%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y+EG+   PY    SD  A++   YR+D  ++EP VA PH P+N     E  +
Sbjct: 230 PDETTRVYVEGRCKRPYRFYRSDPDAKYEKIYRYDAAQIEPQVAFPHLPENSRPVSEAGN 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           ++I++V IGSCT G+ ED   AA+V     G+KV   V   + P T K+++         
Sbjct: 290 IEIDQVVIGSCTNGRMEDLREAARVL---KGRKVHKNVRLIIFPGTPKIYLQALR----- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   + F EAG    ++P+CG CLGG     AR    + CV+TTNRNF GRMGH E 
Sbjct: 342 ---EGLIETFVEAG-GVVSTPTCGPCLGGHSGILAR---GERCVATTNRNFVGRMGHPES 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL +P  AAAS
Sbjct: 395 EVYLSNPAVAAAS 407

[59][TOP]
>UniRef100_C0V4R3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Veillonella
           parvula DSM 2008 RepID=C0V4R3_9FIRM
          Length = 419

 Score =  132 bits (333), Expect = 1e-29
 Identities = 82/193 (42%), Positives = 113/193 (58%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KD 180
           D+IT +Y++G+ + P E +  D  A +      D++KL+P+VA PH P N     E  KD
Sbjct: 230 DAITEEYIKGRVNRPVEPIAPDADAVYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKD 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           +KI++V IGSCT G+ ED +AAA++F    G+KV   V   ++P +Q    DVY   +  
Sbjct: 290 IKIDQVIIGSCTNGRYEDLVAAAEIFK---GRKVAPFVRCIVIPGSQ----DVYDQAMKD 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
                   IF +A C   ++P+CG CLGG     A   E +  VSTTNRNF GRMGH + 
Sbjct: 343 G----LLDIFIQADCAV-STPTCGPCLGGYMGIMA---EGERTVSTTNRNFRGRMGHVDS 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL SPY AAAS
Sbjct: 395 EVYLASPYVAAAS 407

[60][TOP]
>UniRef100_C4FRW1 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC
           17748 RepID=C4FRW1_9FIRM
          Length = 419

 Score =  132 bits (332), Expect = 2e-29
 Identities = 81/193 (41%), Positives = 113/193 (58%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KD 180
           D++T +Y++G+ + P E +  D  A +      D++KL+P+VA PH P N     E  KD
Sbjct: 230 DAVTEEYIKGRVNRPVEPIAPDADAVYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKD 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           +KI++V IGSCT G+ ED +AAA++F    G+KV   V   ++P +Q    DVY   +  
Sbjct: 290 IKIDQVIIGSCTNGRYEDLVAAAEIFK---GRKVAPFVRCIVIPGSQ----DVYDQAMKD 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
                   IF +A C   ++P+CG CLGG     A   E +  VSTTNRNF GRMGH + 
Sbjct: 343 G----LLDIFIQADCAV-STPTCGPCLGGYMGIMA---EGERTVSTTNRNFRGRMGHVDS 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL SPY AAAS
Sbjct: 395 EVYLASPYVAAAS 407

[61][TOP]
>UniRef100_Q12TV2 Homoaconitase large subunit n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=Q12TV2_METBU
          Length = 413

 Score =  132 bits (331), Expect = 2e-29
 Identities = 76/191 (39%), Positives = 109/191 (57%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+ +LEG+    YE VY+D+ A + +EY  D   LEP +A PH  DN     E + 
Sbjct: 227 PDQKTFDFLEGRAVEGYEPVYADEDAEYCAEYDIDGANLEPQIALPHQVDNVCDVSEIEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
            K+++V+IG+CT G+ ED   AA++     G++V V T ++PA++ + ++          
Sbjct: 287 KKVDQVFIGTCTNGRLEDLEVAAEIL---KGEQVAVRTIVIPASRSIMLEAVR------- 336

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
               ++   +AG  T  SP CG CLGG       + E +VC+ST NRNF GRMG + G I
Sbjct: 337 -NGTAETLLDAGV-TLGSPGCGPCLGGHMGV---IGEGEVCISTANRNFRGRMG-KGGFI 390

Query: 541 YLVSPYTAAAS 573
           YL SP TAAAS
Sbjct: 391 YLSSPATAAAS 401

[62][TOP]
>UniRef100_C0FYL9 Putative uncharacterized protein n=1 Tax=Roseburia inulinivorans
           DSM 16841 RepID=C0FYL9_9FIRM
          Length = 436

 Score =  131 bits (329), Expect = 4e-29
 Identities = 78/192 (40%), Positives = 109/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +  +Y+E  +  PY    +D+ A + +EY  D++ L+P V+ PH P+N     E  DV
Sbjct: 247 DDLAKQYMEEHSKRPYVVYEADEDAEYDAEYTIDLSTLKPTVSFPHLPENTRTIDEVGDV 306

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ +D   AA V     GKKVK  +   ++PATQK+++          
Sbjct: 307 KIDQVVIGSCTNGRMDDLRIAASVL---KGKKVKKGLRVIVIPATQKIYLQAME------ 357

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAG    ++P+CG CLGG     A     + CVSTTNRNF GRMGH + E
Sbjct: 358 --EGLLRTFIEAGA-VVSTPTCGPCLGGYMGILA---AGERCVSTTNRNFVGRMGHVDSE 411

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 412 VYLASPAVAAAS 423

[63][TOP]
>UniRef100_C4ZBK5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Eubacterium
           rectale ATCC 33656 RepID=C4ZBK5_EUBR3
          Length = 420

 Score =  130 bits (328), Expect = 5e-29
 Identities = 77/192 (40%), Positives = 108/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +Y++  +  P+    +D  A +  EY  D++ L+  V+ PH PDN     E  DV
Sbjct: 231 DDLTREYMKEHSKRPFTEYEADSDAEYDEEYTIDLSTLKSTVSFPHLPDNTRTIDEVGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ +D   AAK+     GKKV   +   ++PATQK+++          
Sbjct: 291 KIDQVVIGSCTNGRMDDLRIAAKIL---EGKKVADGIRVIVIPATQKIYLQAME------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAG    ++P+CG CLGG     A   E + CVSTTNRNF GRMGH + E
Sbjct: 342 --EGLLKTFIEAGA-IVSTPTCGPCLGGYMGVLA---EGERCVSTTNRNFVGRMGHVDSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[64][TOP]
>UniRef100_C0EDN6 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EDN6_9CLOT
          Length = 421

 Score =  130 bits (327), Expect = 7e-29
 Identities = 77/192 (40%), Positives = 108/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y++ K + PY +   D  A + + Y  D+++++  V+ PH PDN     E  DV
Sbjct: 231 DEVTIAYMKDKVNRPYTAYAPDPDAEYDAVYDIDLSQIKSTVSFPHLPDNTRTIDEVGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AAK+     GK+V   V   ++PATQK++++   L     
Sbjct: 291 KIDQVVIGSCTNGRLSDIAVAAKIL---EGKQVAKHVRAIVIPATQKIYLEALKLGY--- 344

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                 + F +AGC   ++P+CG CLGG     A     +  VSTTNRNF GRMGH E E
Sbjct: 345 -----LETFVKAGC-VVSTPTCGPCLGGHMGILA---AGERAVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPEVAAAS 407

[65][TOP]
>UniRef100_Q8TVF2 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Methanopyrus
           kandleri RepID=LEUC1_METKA
          Length = 418

 Score =  130 bits (327), Expect = 7e-29
 Identities = 80/193 (41%), Positives = 109/193 (56%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++ +       V  D  AR+ +E   DV+ LEP VAKP SPDN     E + 
Sbjct: 228 PDEKTLEYVKKRAGTEGRPVEPDPDARYEAELTLDVSDLEPQVAKPFSPDNVVPVGEVEG 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           + I++V+IGSCT G+ ED   AA+V     G++V   V   ++PA+++V+       V  
Sbjct: 288 IAIDQVFIGSCTNGRYEDLKVAAEVL---EGEEVHDDVRLIVIPASREVYHRTLKDGV-- 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
                  ++  EAG      P+CG CLGG     A   E + CV+T+NRNFPGRMGHRE 
Sbjct: 343 ------LEVLHEAGA-LICPPNCGPCLGGHMGVLA---EGERCVATSNRNFPGRMGHRES 392

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP TAAAS
Sbjct: 393 EVYLASPATAAAS 405

[66][TOP]
>UniRef100_UPI0001966B48 hypothetical protein SUBVAR_01587 n=1 Tax=Subdoligranulum variabile
           DSM 15176 RepID=UPI0001966B48
          Length = 419

 Score =  129 bits (325), Expect = 1e-28
 Identities = 77/192 (40%), Positives = 109/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D I   YL+G++  P+    +D  A +      D+  LEP V+ PH P+N  LA+E KD+
Sbjct: 231 DEICEAYLKGRSQRPWVKYEADPDAEYERTVIIDLDTLEPTVSYPHLPENTHLAKEGKDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI+++ IGSCT G+ ED  AA ++     GK +   V   ++PAT  V+ +         
Sbjct: 291 KIDQIVIGSCTNGRIEDMQAAYEIL---KGKHIAKGVRGIIIPATMAVYKECIL------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +  ++ F +AGC   ++P+CG CLGG     A     + CVSTTNRNF GRMGH + E
Sbjct: 342 --RGYTEAFIDAGC-IVSTPTCGPCLGGYMGILA---AGERCVSTTNRNFVGRMGHVDSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP TAAAS
Sbjct: 396 VYLASPATAAAS 407

[67][TOP]
>UniRef100_B5YEF5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           thermophilum H-6-12 RepID=B5YEF5_DICT6
          Length = 424

 Score =  129 bits (325), Expect = 1e-28
 Identities = 81/195 (41%), Positives = 109/195 (55%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK 177
           PD IT  Y+  +    ++   SD+ A++   Y +DV+ LEP+VA PH P N + ++   K
Sbjct: 230 PDEITLDYVRNRAKRDFKIYKSDEDAQYKEVYEWDVSDLEPIVAFPHLPSNIKKISEISK 289

Query: 178 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVP 351
           D+ I++VYIGSCT G+ ED   AAK+     G KV   V   + PAT  ++M        
Sbjct: 290 DIYIDQVYIGSCTNGRIEDLRIAAKIL---KGHKVHKDVRLIITPATPNIYMQALK---- 342

Query: 352 GSGGKTCSQIFEEAGCD-TPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
               +   +IF EAG   TP  PSCG CLGG     A   E +  V+TTNRNF GRMGH 
Sbjct: 343 ----EGLIEIFLEAGASITP--PSCGPCLGGHLGVLA---EGEKAVATTNRNFVGRMGHP 393

Query: 529 EGEIYLVSPYTAAAS 573
           + E+YL +P  AAAS
Sbjct: 394 KSEVYLSNPAVAAAS 408

[68][TOP]
>UniRef100_B1I1Y2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Candidatus
           Desulforudis audaxviator MP104C RepID=B1I1Y2_DESAP
          Length = 420

 Score =  129 bits (324), Expect = 2e-28
 Identities = 78/191 (40%), Positives = 106/191 (55%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++G+T  P+E   SD  A +     +DV+K+EP VA PHSPDN     E   
Sbjct: 230 PDIRTLEYVQGRTIRPFELFASDPDAVYARTITYDVSKIEPQVAFPHSPDNTRPVTEAGR 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V+I++V IGSCT G+ ED   AA+V L        V   ++P TQ+++            
Sbjct: 290 VEIDQVVIGSCTNGRMEDLRLAARV-LERRRVHAGVRLIVIPGTQEIYRQAME------- 341

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +    IF +AG    ++P+CG CLGG     AR    +  V+TTNRNF GRMGH E E+
Sbjct: 342 -EGLLAIFIQAGA-AVSTPTCGPCLGGHMGVLAR---GERAVATTNRNFVGRMGHPESEV 396

Query: 541 YLVSPYTAAAS 573
           YL +P  AAAS
Sbjct: 397 YLTNPAVAAAS 407

[69][TOP]
>UniRef100_C1QEQ6 3-isopropylmalate dehydratase large subunit n=1 Tax=Brachyspira
           murdochii DSM 12563 RepID=C1QEQ6_9SPIR
          Length = 201

 Score =  129 bits (324), Expect = 2e-28
 Identities = 77/192 (40%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+ T +YL+      Y    +D  A +  EY  D++ +EP VA PH P+N   A+E KD+
Sbjct: 15  DNQTIEYLKDIVKRDYTIYKADDDAVYEKEYDIDLSSIEPTVACPHLPENTKDAKELKDI 74

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           K+++V IGSCT G+  D   AA +     GKK+   V   ++PATQKV+ +   L     
Sbjct: 75  KVDQVVIGSCTNGRLSDMATAANIL---KGKKIAKNVRCIIIPATQKVYKECIKLGY--- 128

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                  IF +AGC   ++P+CG CLGG     A     +V V+TTNRNF GRMG +  +
Sbjct: 129 -----MDIFIDAGC-AVSTPTCGPCLGGYMGILA---HDEVAVTTTNRNFVGRMGDKTSK 179

Query: 538 IYLVSPYTAAAS 573
           +YL SP TAA S
Sbjct: 180 VYLASPATAAYS 191

[70][TOP]
>UniRef100_A8UWH6 3-isopropylmalate dehydratase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1
           RepID=A8UWH6_9AQUI
          Length = 432

 Score =  129 bits (324), Expect = 2e-28
 Identities = 77/195 (39%), Positives = 108/195 (55%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++ +    ++   SD  A + S Y +D +K+EPLVA P+ P N     E   
Sbjct: 229 PDDKTIEYVKERAQKEWKVYESDPDAEYHSVYEWDASKIEPLVAWPYLPSNVHPVSESTH 288

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLAS--GGKKVK--VPTFLVPATQKVWMDVYSLPV 348
           + +++ +IGSCT G+ ED   AAKVF ++   GKKV   V   ++PA++ V+M       
Sbjct: 289 INVDQAFIGSCTNGRIEDLRIAAKVFESALKQGKKVHPYVRCIVIPASKNVYMQAMK--- 345

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF EAGC    S +CG CLGG     A   E + C+ST+NRNFPGRMGH 
Sbjct: 346 -----EGLIDIFMEAGCAVSTS-TCGPCLGGHMGVLA---EGERCISTSNRNFPGRMGHP 396

Query: 529 EGEIYLVSPYTAAAS 573
           + E YL +P   AAS
Sbjct: 397 KSESYLANPAVVAAS 411

[71][TOP]
>UniRef100_O67078 3-isopropylmalate dehydratase large subunit n=1 Tax=Aquifex
           aeolicus RepID=LEUC_AQUAE
          Length = 432

 Score =  129 bits (323), Expect = 2e-28
 Identities = 77/195 (39%), Positives = 108/195 (55%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++ +   P++   SD  A + S Y +D +++EPLVA P+ P N     E   
Sbjct: 229 PDEKTIEYVKQRAKRPWKVYQSDPDAEYHSVYEWDASQIEPLVAWPYLPSNVHPVSESTH 288

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLAS--GGKKVK--VPTFLVPATQKVWMDVYSLPV 348
           + I++ +IGSCT G+ ED   AAKVF A+   GKKV   V   ++PA++ ++        
Sbjct: 289 ITIDQAFIGSCTNGRIEDLRVAAKVFEAALKQGKKVHPYVRCIVIPASKAIYKQALK--- 345

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF EAGC    S +CG CLGG     A   E + C+ST+NRNFPGRMGH 
Sbjct: 346 -----EGLIDIFMEAGCVVSTS-TCGPCLGGHMGVLA---EGERCISTSNRNFPGRMGHP 396

Query: 529 EGEIYLVSPYTAAAS 573
           + E YL +P   AAS
Sbjct: 397 KSESYLANPAVVAAS 411

[72][TOP]
>UniRef100_B8E2X0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           turgidum DSM 6724 RepID=B8E2X0_DICTD
          Length = 424

 Score =  128 bits (321), Expect = 4e-28
 Identities = 82/195 (42%), Positives = 108/195 (55%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK 177
           PD IT +Y+  +    ++   SD+ A +   Y +DVT LEP+VA PH P N + ++   K
Sbjct: 230 PDEITLEYVRNRAKRNFKVYKSDEDAHYKEIYEWDVTNLEPIVAFPHLPSNIKKISDIGK 289

Query: 178 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVP 351
           D+ I++VYIGSCT G+ ED   AAK+     G KV   V   + PAT  V+M        
Sbjct: 290 DIYIDQVYIGSCTNGRIEDLRLAAKIL---KGHKVHKDVRLIVTPATPNVYMQALK---- 342

Query: 352 GSGGKTCSQIFEEAGCD-TPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
               +   +IF E G   TP  PSCG CLGG     A   E +  V+TTNRNF GRMGH 
Sbjct: 343 ----EGLIEIFLEVGASITP--PSCGPCLGGHLGVLA---EGEKAVATTNRNFVGRMGHP 393

Query: 529 EGEIYLVSPYTAAAS 573
           + E+YL +P  AAAS
Sbjct: 394 KSEVYLSNPAVAAAS 408

[73][TOP]
>UniRef100_B5YKE0 3-isopropylmalate dehydratase large subunit n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=LEUC_THEYD
          Length = 421

 Score =  127 bits (320), Expect = 5e-28
 Identities = 76/193 (39%), Positives = 109/193 (56%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT +Y++ +   PY+   SDQ A++     +D +++ P+VA PH P N   A E   
Sbjct: 230 PDKITEEYVKLRAKRPYKIYNSDQDAKYFEIKEYDCSRIPPVVACPHLPSNVKPANELSH 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           +KI++V IGSCT G+ ED   AA V     G+KV  +V   ++PATQK++M         
Sbjct: 290 IKIDQVVIGSCTNGRLEDLREAAMVL---KGRKVHPEVRMIIIPATQKIYMQALK----- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +A     + P+CG CLGG     A+    +  ++TTNRNF GRMGH E 
Sbjct: 342 ---EGLIEIFIDAQA-VVSPPTCGPCLGGHMGILAK---GERAIATTNRNFVGRMGHPES 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL +P  AAAS
Sbjct: 395 EVYLSNPAVAAAS 407

[74][TOP]
>UniRef100_A6TTR7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Alkaliphilus
           metalliredigens QYMF RepID=A6TTR7_ALKMQ
          Length = 420

 Score =  127 bits (318), Expect = 8e-28
 Identities = 77/192 (40%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +Y+   +  PY    +D+ A +   Y  D+++L P VA PH PDN     E  DV
Sbjct: 231 DELTLEYVRVHSKRPYTVYRADEDAVYEETYEIDLSRLLPTVAFPHIPDNIRTIDEVGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ +D   AAKV     GK+V   V   + PATQK+++D         
Sbjct: 291 KIDQVVIGSCTNGRIQDLRMAAKVM---EGKQVAKGVRVIVFPATQKIYLDAMK------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F +AG    ++P+CG CLGG     A+    +  ++TTNRNF GRMGH E E
Sbjct: 342 --EGLLETFIKAGA-VVSTPTCGPCLGGHMGVLAK---GERAIATTNRNFVGRMGHPESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[75][TOP]
>UniRef100_B0PBC0 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PBC0_9FIRM
          Length = 419

 Score =  126 bits (317), Expect = 1e-27
 Identities = 74/192 (38%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y++G+ +  YE+   D  A +      D++ + P VA PH P+N     E  DV
Sbjct: 231 DEVTRAYMQGRVNRTYETFMPDDGAAYARVIEIDLSSIRPTVAFPHLPENTRTVDEAGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           +I++V IGSCT G+  D  AAA++     GKKV   V   ++P TQ+++ +         
Sbjct: 291 RIDQVVIGSCTNGRIGDLAAAARLM---SGKKVADGVRCIVIPGTQQIYREAIHAGY--- 344

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                   F +AGC   ++P+CG CLGG     A   E + CV+TTNRNF GRMGH + E
Sbjct: 345 -----IDTFLDAGC-AVSTPTCGPCLGGYMGILA---EGERCVATTNRNFVGRMGHVKSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[76][TOP]
>UniRef100_B0TCR2 3-isopropylmalate dehydratase large subunit n=1 Tax=Heliobacterium
           modesticaldum Ice1 RepID=LEUC_HELMI
          Length = 420

 Score =  126 bits (317), Expect = 1e-27
 Identities = 77/193 (39%), Positives = 105/193 (54%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y+E + + PY+   SD  A++    ++DV KLEP+VA PH P+N     E   
Sbjct: 230 PDKKTIAYVEERATRPYKVYTSDPDAKYARVIKYDVEKLEPVVAFPHLPENTRPVSEAGH 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           V+I++V IGSCT G+ ED   AAK+     GKKV   V   + P TQ ++          
Sbjct: 290 VEIDQVVIGSCTNGRIEDLRMAAKIL---QGKKVHKNVRCIIFPGTQAIYKQAIK----- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF +AG    ++P+CG CLGG     A+    +  ++TTNRNF GRMGH E 
Sbjct: 342 ---EGLIDIFIDAGA-AVSTPTCGPCLGGHMGILAK---GERALATTNRNFVGRMGHPES 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL  P  AAAS
Sbjct: 395 EVYLCGPNVAAAS 407

[77][TOP]
>UniRef100_B8CX22 3-isopropylmalate dehydratase large subunit n=1 Tax=Halothermothrix
           orenii H 168 RepID=LEUC_HALOH
          Length = 420

 Score =  126 bits (317), Expect = 1e-27
 Identities = 75/191 (39%), Positives = 101/191 (52%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+KYLE +    Y   YSD  A +     +DV+ +EP VA PH P+N     E  D
Sbjct: 230 PDEKTFKYLENRAQRDYTPCYSDDDAEYEKVIEYDVSDIEPQVAFPHLPENTRPISEEGD 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           +KI++  IGSCT G+ ED   AA + L        V   ++P TQ ++            
Sbjct: 290 IKIDQAVIGSCTNGRMEDLRIAAGI-LKEKQVHHDVRCIVIPGTQDIYKQALK------- 341

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   +IF EAG    ++P+CG CLGG     AR    +  ++TTNRNF GRMGH E E+
Sbjct: 342 -EGLIEIFIEAGA-AVSTPTCGPCLGGHMGILAR---GEKAIATTNRNFVGRMGHPESEV 396

Query: 541 YLVSPYTAAAS 573
           YL +P  AAAS
Sbjct: 397 YLANPAVAAAS 407

[78][TOP]
>UniRef100_C7H4B6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Faecalibacterium prausnitzii A2-165
           RepID=C7H4B6_9FIRM
          Length = 419

 Score =  126 bits (316), Expect = 1e-27
 Identities = 81/195 (41%), Positives = 109/195 (55%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGK---TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC 174
           D +T  YL G+   T V YE+   D  A +      D+ KLEP V+ PH P+N   A E 
Sbjct: 231 DEVTRAYLNGRSQRTPVYYEA---DPDAEYEKTIEIDLDKLEPTVSYPHLPENTHPASEG 287

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPV 348
           KD++I++V IGSCT G+ ED  AA  +     GK +   V   ++PAT  V+ +      
Sbjct: 288 KDIRIDQVVIGSCTNGRLEDMEAAYNIL---KGKHIAKGVRGIIIPATMAVYKECIL--- 341

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +  ++ F +AGC   ++P+CG CLGG     A   E + CVSTTNRNF GRMGH 
Sbjct: 342 -----RGWTEAFIDAGC-IVSTPTCGPCLGGYMGILA---EGERCVSTTNRNFVGRMGHV 392

Query: 529 EGEIYLVSPYTAAAS 573
           + E+YL SP TAAAS
Sbjct: 393 KSEVYLASPATAAAS 407

[79][TOP]
>UniRef100_B4U7U5 3-isopropylmalate dehydratase large subunit n=1
           Tax=Hydrogenobaculum sp. Y04AAS1 RepID=LEUC_HYDS0
          Length = 424

 Score =  126 bits (316), Expect = 1e-27
 Identities = 73/193 (37%), Positives = 105/193 (54%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y+E +   PY+   SD+ A ++  Y +D + +EP+VA P+ P N     E   
Sbjct: 229 PDEKTIEYVEKRAKKPYKIYQSDKDAHYVEVYEWDASSIEPMVAWPYLPSNVHPVSESTH 288

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVPG 354
           + I++ +IGSCT G+ ED   AA +     GKKV   T   ++PA++ V++         
Sbjct: 289 ITIDQAFIGSCTNGRIEDLRIAASIL---KGKKVHPYTRCVVIPASKNVYLQALH----- 340

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF EAGC    S +CG CLGG     A+    + C+ST+NRNFPGRMGH + 
Sbjct: 341 ---EGLVDIFIEAGCAVSTS-TCGPCLGGHMGILAK---GERCISTSNRNFPGRMGHPQS 393

Query: 535 EIYLVSPYTAAAS 573
           E YL +P   AAS
Sbjct: 394 EAYLANPAVVAAS 406

[80][TOP]
>UniRef100_UPI00016C08CB 3-isopropylmalate dehydratase, large subunit n=1 Tax=Epulopiscium
           sp. 'N.t. morphotype B' RepID=UPI00016C08CB
          Length = 421

 Score =  125 bits (315), Expect = 2e-27
 Identities = 77/192 (40%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT +YL+G+T   Y    SD  A +      D++K+ P V+ PHSPDN     E  ++
Sbjct: 231 DFITREYLKGRTDREYIVYTSDADAIYDEVITIDLSKVRPTVSCPHSPDNTXTLDELPEI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED   A+ +     GKKV   V   + P TQ++++D  +  +  +
Sbjct: 291 KIDQVVIGSCTNGRLEDLRMASDIL---KGKKVAKGVRAIVFPGTQQIYLDALAEGIVTN 347

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                     +AGC   ++P+CG CLGG     A+    +  VSTTNRNF GRMGH E E
Sbjct: 348 --------LVKAGC-VMSTPTCGPCLGGHMGILAK---GEKAVSTTNRNFVGRMGHIESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[81][TOP]
>UniRef100_C0R088 3-isopropylmalate dehydratase large subunit n=1 Tax=Brachyspira
           hyodysenteriae WA1 RepID=C0R088_BRAHW
          Length = 415

 Score =  125 bits (315), Expect = 2e-27
 Identities = 77/192 (40%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL+      Y    +D  A +  EY  D++ +EP VA PH P+N   A+E K++
Sbjct: 229 DDQTIEYLKDIVKRDYTVFKADDDAVYDKEYDIDLSLIEPTVACPHLPENTKEAKELKNI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           K+++V IGSCT G+  D   AA +     GKKV   V   ++PATQKV+ +   L     
Sbjct: 289 KVDQVVIGSCTNGRLSDMATAANIL---KGKKVAKGVRCIVIPATQKVYKECIKLGY--- 342

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                  IF +AGC   ++P+CG CLGG     A     +V V+TTNRNF GRMG +  +
Sbjct: 343 -----MDIFIDAGC-AVSTPTCGPCLGGYMGILA---HDEVAVTTTNRNFVGRMGDKTSK 393

Query: 538 IYLVSPYTAAAS 573
           +YL SP TAA S
Sbjct: 394 VYLASPATAAYS 405

[82][TOP]
>UniRef100_Q46B45 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosarcina
           barkeri str. Fusaro RepID=Q46B45_METBF
          Length = 413

 Score =  125 bits (315), Expect = 2e-27
 Identities = 75/191 (39%), Positives = 106/191 (55%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+ +L+ + + PY+ VY+DQ A ++ E  +    +EP VA PH  DN     E + 
Sbjct: 227 PDEKTFAFLKNRAAAPYDPVYADQDAVYVKEPVYSAEDIEPQVACPHQVDNVKPVGEVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             I++V+IG+CT G+ ED   AA +     GKKV V T ++PA++   +           
Sbjct: 287 THIDQVFIGTCTNGRLEDLEVAAAIL---KGKKVAVRTIVIPASRTTLLAAIE------- 336

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +I  +AG  T A+P CG CLG  +     + E +VC+ST NRNF GRMG + G I
Sbjct: 337 -NGTMEILLKAGI-TLATPGCGPCLGAHQGV---LGEGEVCLSTANRNFKGRMG-KSGFI 390

Query: 541 YLVSPYTAAAS 573
           YL SP TAAAS
Sbjct: 391 YLASPATAAAS 401

[83][TOP]
>UniRef100_Q8TLF1 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina acetivorans RepID=LEUC1_METAC
          Length = 424

 Score =  125 bits (315), Expect = 2e-27
 Identities = 75/191 (39%), Positives = 106/191 (55%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+++L+ + +  YE VY+D  A +L E+ +D   +EP VA PH  DN     E + 
Sbjct: 238 PDEKTFEFLKNRAAATYEPVYADPDAVYLEEFTYDADDIEPQVACPHQVDNVKPVGEVEG 297

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++V+IG+CT G+ ED   AA V     GK+V V T ++PA++   +           
Sbjct: 298 THVDQVFIGTCTNGRLEDLEVAAAVL---KGKQVAVRTIVIPASRTTLLAAIE------- 347

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +   +AG  T A+P CG CLG  +     + E +VCVST NRNF GRMG + G I
Sbjct: 348 -NGTMETLLKAGV-TLATPGCGPCLGAHQGV---LGEGEVCVSTANRNFKGRMG-KGGFI 401

Query: 541 YLVSPYTAAAS 573
           YL SP TAAAS
Sbjct: 402 YLASPATAAAS 412

[84][TOP]
>UniRef100_C6LJ75 3-isopropylmalate dehydratase, large subunit n=1 Tax=Bryantella
           formatexigens DSM 14469 RepID=C6LJ75_9FIRM
          Length = 422

 Score =  125 bits (314), Expect = 2e-27
 Identities = 77/193 (39%), Positives = 108/193 (55%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KD 180
           D +   Y++  +  PY+   +D+ A +  EY  D++ L+P VA PH P+N     E  +D
Sbjct: 231 DDLAIAYMKEHSQRPYKIYEADEDAVYDEEYTIDLSALKPTVAFPHLPENTKTIDEITED 290

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           V I++  IGSCT G+ +D   AAK+     G+KVK  V   ++PATQKV++         
Sbjct: 291 VVIDQAVIGSCTNGRIDDLRCAAKIL---EGRKVKKGVRCIVIPATQKVYLQAME----- 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   + F EAG    ++P+CG CLGG     A   E + C+STTNRNF GRMGH   
Sbjct: 343 ---EGLLKTFIEAGA-VVSTPTCGPCLGGYMGILA---EGERCISTTNRNFVGRMGHVNS 395

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 396 EVYLASPAVAAAS 408

[85][TOP]
>UniRef100_A3DHI4 3-isopropylmalate dehydratase large subunit n=3 Tax=Clostridium
           thermocellum RepID=LEUC_CLOTH
          Length = 419

 Score =  125 bits (314), Expect = 2e-27
 Identities = 74/192 (38%), Positives = 109/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++  ++  Y+   +D+ A +++ Y  D+++++P VA PH P N        ++
Sbjct: 231 DEKTIEYVKEHSTRQYKVYKADEDAEYVATYEIDLSQVKPTVAFPHLPSNTRTIDNVGNI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED   AA+V     G+KV   V   ++PATQK+W    +      
Sbjct: 291 KIDQVVIGSCTNGRIEDLRVAAEVL---KGRKVHKDVRCIIIPATQKIWKQAMN------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E E
Sbjct: 342 --EGLFDIFIDAGA-AVSTPTCGPCLGGHMGILAK---GERAVATTNRNFVGRMGHPESE 395

Query: 538 IYLVSPYTAAAS 573
           IYL SP  AAAS
Sbjct: 396 IYLASPAVAAAS 407

[86][TOP]
>UniRef100_B9L0Y1 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0Y1_THERP
          Length = 422

 Score =  125 bits (313), Expect = 3e-27
 Identities = 81/192 (42%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T ++L   T+ PYE V SD  AR+     FDV+ L PLVA PH P N   A E +D+
Sbjct: 233 DDKTREWLAKVTTEPYEPVDSDPDARYAQIIEFDVSNLRPLVALPHLPSNVRPADEVRDL 292

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+  D   AA++     G++V  +V   ++P +Q+V           +
Sbjct: 293 PIDQVVIGSCTNGRLSDLRIAAEIL---KGRQVHPRVRCIVIPGSQEV--------AKQA 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF EAG     S +CG CLGG     A+    + CVSTTNRNF GRMGHRE E
Sbjct: 342 TREGLVDIFLEAGAVFSVS-TCGPCLGGYMGVLAK---GERCVSTTNRNFRGRMGHRESE 397

Query: 538 IYLVSPYTAAAS 573
           + L SP  AAAS
Sbjct: 398 VILASPAVAAAS 409

[87][TOP]
>UniRef100_C4G1B4 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1B4_ABIDE
          Length = 421

 Score =  125 bits (313), Expect = 3e-27
 Identities = 76/192 (39%), Positives = 108/192 (56%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y++  ++ PY+   +D+ A +      ++++LEP VA PH P+N     E  D+
Sbjct: 231 DELTLNYIKEHSTKPYKVYEADEDAVYDEVIEINLSELEPTVAFPHLPENTRTIGETGDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AA+V     GKKV   +   ++PATQ+V++         S
Sbjct: 291 KIDQVVIGSCTNGRISDIRVAAEVM---KGKKVAPGIRVIVIPATQEVYLT--------S 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +     F +AGC   ++P+CG CLGG     A     +  VSTTNRNF GRMGH E E
Sbjct: 340 LKEGLITTFVQAGC-IVSTPTCGPCLGGHMGVLA---AGERAVSTTNRNFVGRMGHTESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[88][TOP]
>UniRef100_A8S7H1 Putative uncharacterized protein n=1 Tax=Faecalibacterium
           prausnitzii M21/2 RepID=A8S7H1_9FIRM
          Length = 419

 Score =  125 bits (313), Expect = 3e-27
 Identities = 77/192 (40%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  YL G++  P     +D  A +      D++ LEP V+ PH P+N  +A E KD+
Sbjct: 231 DEVTKAYLAGRSQRPPVFYEADPDAVYEKTIEIDLSALEPTVSYPHLPENTHVASEGKDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED  AA  +     GK +   V   ++PAT  V+ +         
Sbjct: 291 KIDQVVIGSCTNGRLEDMEAAYNIL---KGKHIAKGVRGIIIPATMAVYKECIL------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +  +  F +AGC   ++P+CG CLGG     A     + CVSTTNRNF GRMGH + E
Sbjct: 342 --RGWTTAFIDAGC-IVSTPTCGPCLGGYMGILA---AGERCVSTTNRNFVGRMGHVDSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP TAAAS
Sbjct: 396 VYLASPATAAAS 407

[89][TOP]
>UniRef100_Q3Z9A7 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides
           ethenogenes 195 RepID=Q3Z9A7_DEHE1
          Length = 417

 Score =  124 bits (311), Expect = 5e-27
 Identities = 75/191 (39%), Positives = 107/191 (56%), Gaps = 1/191 (0%)
 Frame = +1

Query: 4   DSITYKYLEGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           D  T +YL        Y+ + +D+ A +      D T LEP+VAKPH+ DN A ARE K 
Sbjct: 227 DRQTLEYLRSVGREADYQPLAADEDAVYERVIEIDATALEPMVAKPHTVDNTATARELKG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
            K+++V+IG+CTGG+ +D   AA +F  +     +    + PA+QKV+++   L      
Sbjct: 287 TKLDQVFIGTCTGGRLDDLAVAAAIF-KNRRHHPQTRLIVTPASQKVYLEAIRLGY---- 341

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +I  +AG +    P CGACLG  +     + + +VC+ST NRNF GRMG+ EG I
Sbjct: 342 ----IEILVQAGANV-MPPGCGACLGVHQGV---LGDGEVCLSTANRNFKGRMGNPEGFI 393

Query: 541 YLVSPYTAAAS 573
           YL S  TAAAS
Sbjct: 394 YLASAATAAAS 404

[90][TOP]
>UniRef100_C7II84 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           papyrosolvens DSM 2782 RepID=C7II84_9CLOT
          Length = 419

 Score =  124 bits (310), Expect = 7e-27
 Identities = 73/192 (38%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++  +   Y    +D+ A++   Y  D+ +++P VA PH P+N     +  D+
Sbjct: 231 DEKTVEYVKEHSIRSYTVYKADEDAQYSEVYEIDLAEIKPTVAFPHLPENARTIDKVGDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED   AA++     G+KV   V   ++PATQK+W    +      
Sbjct: 291 KIDQVVIGSCTNGRIEDMRIAAQIL---KGQKVSDNVRCIIIPATQKIWKQAMN------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E E
Sbjct: 342 --EGLFDIFIDAGA-AVSTPTCGPCLGGHMGILAK---GERAVATTNRNFVGRMGHPESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[91][TOP]
>UniRef100_C4EWE6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermanaerovibrio acidaminovorans DSM 6589
           RepID=C4EWE6_9BACT
          Length = 417

 Score =  124 bits (310), Expect = 7e-27
 Identities = 80/191 (41%), Positives = 104/191 (54%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y+  +    +E VY D  A +  E    +  L PLVA P+ P N   ARE +D
Sbjct: 227 PDEATLAYVAPRARRSFEPVYPDPGAAYERELTVRLDSLPPLVACPNLPSNVRPARELRD 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V+I++V+IGSCT G+ ED   AAKV L        V   L+PA+++   D+ +    G  
Sbjct: 287 VEIHQVFIGSCTNGRIEDLRQAAKV-LKGRRLHPSVRGVLIPASRR---DMAAAMQEG-- 340

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                ++F EAG     +PSCG CLGG     A   E +VCVST NRNF GRMGH   ++
Sbjct: 341 ---LMEVFMEAGFSI-CTPSCGPCLGGHLGILA---EGEVCVSTGNRNFTGRMGHPRSQV 393

Query: 541 YLVSPYTAAAS 573
           YL SP  AAAS
Sbjct: 394 YLASPAVAAAS 404

[92][TOP]
>UniRef100_C9L6F6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Blautia
           hansenii DSM 20583 RepID=C9L6F6_RUMHA
          Length = 425

 Score =  123 bits (309), Expect = 9e-27
 Identities = 77/193 (39%), Positives = 107/193 (55%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D  T +Y++  +  PY+    D+ A +  EY  D++KL P VA PH P N     E +D 
Sbjct: 234 DEKTEEYMKEHSKRPYKRYEPDEDAVYDEEYTIDLSKLRPTVAFPHLPSNTKTIDEIQDD 293

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           V I +  IGSCT G+ +D   AA++      +KVK  V   ++PATQK+++         
Sbjct: 294 VIIQQSVIGSCTNGRIDDLRCAAQILK---NRKVKKGVRCIIIPATQKIYLQALE----- 345

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF EAG    ++P+CG CLGG     A   E + C+STTNRNF GRMGH + 
Sbjct: 346 ---EGLLKIFIEAGA-VVSTPTCGPCLGGYMGILA---EGERCISTTNRNFVGRMGHVKS 398

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 399 EVYLASPAVAAAS 411

[93][TOP]
>UniRef100_B1H0A6 3-isopropylmalate dehydratase large subunit n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=LEUC_UNCTG
          Length = 420

 Score =  123 bits (309), Expect = 9e-27
 Identities = 75/193 (38%), Positives = 103/193 (53%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT  Y+  +    Y+   SD+ A++L  Y  D +K+ P V+ P  P N    ++ K 
Sbjct: 230 PDEITENYVAKRAQRKYKFYISDKDAKYLKIYEIDCSKILPQVSMPFLPSNTKAVKDIKK 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
             I++V IGSCT G+ ED   AA +     GKKV   V T ++PAT +V+          
Sbjct: 290 TYIDQVVIGSCTNGRIEDLRVAASII--KKGKKVNSNVRTLIIPATPEVYSQALD----- 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AG    A P+CG CLGG     A     + C STTNRNF GRMGH E 
Sbjct: 343 ---EGLLRIFMDAGAIISA-PTCGPCLGGHMGILA---SGEKCASTTNRNFRGRMGHVES 395

Query: 535 EIYLVSPYTAAAS 573
           +++LV+P  AAAS
Sbjct: 396 QLFLVNPAVAAAS 408

[94][TOP]
>UniRef100_Q2RG98 3-isopropylmalate dehydratase large subunit n=1 Tax=Moorella
           thermoacetica ATCC 39073 RepID=LEUC_MOOTA
          Length = 421

 Score =  122 bits (307), Expect = 1e-26
 Identities = 73/192 (38%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y+ G+    Y    SD  AR+  E   D +K+EP VA PH P+N    +E  ++
Sbjct: 231 DEKTVEYIRGRLQRDYRIYQSDPDARYNQEIDIDASKIEPQVALPHLPENARSVKEIGEI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED   AA++     G+KV  +V   ++P TQ+++    +      
Sbjct: 291 KIDQVVIGSCTNGRLEDLRVAAQIL---KGQKVHPEVRLIVIPGTQQIYAAALA------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +     F EAG    ++P+CG CLGG     A+    +  ++TTNRNF GRMGH E E
Sbjct: 342 --EGLIATFIEAGA-AVSTPTCGPCLGGHMGILAK---GERALATTNRNFVGRMGHPESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL  P  AAAS
Sbjct: 396 VYLAGPAVAAAS 407

[95][TOP]
>UniRef100_UPI00019E5A8A 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=UPI00019E5A8A
          Length = 310

 Score =  122 bits (306), Expect = 2e-26
 Identities = 75/193 (38%), Positives = 107/193 (55%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT  Y+EG+   PY    SD  A +    R+D +K+EPLVA PH P+N     +   
Sbjct: 120 PDEITRAYVEGRVKKPYTFYKSDADAVYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGL 179

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           V++++V IGSCT G+ ED   AA V     GKKV  ++   ++P TQ+++          
Sbjct: 180 VELDQVVIGSCTNGRMEDLRLAAGVL---KGKKVSDRIRLIVIPGTQQIYKQAMR----- 231

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AG    ++P+CG CLGG     A+    +  ++TTNRNF GRMG  E 
Sbjct: 232 ---EGLIEIFIDAG-GAVSTPTCGPCLGGYMGILAK---GERSLATTNRNFVGRMGSPES 284

Query: 535 EIYLVSPYTAAAS 573
           E+YL +P  AAAS
Sbjct: 285 EVYLCNPAVAAAS 297

[96][TOP]
>UniRef100_Q3AEQ4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AEQ4_CARHZ
          Length = 421

 Score =  122 bits (306), Expect = 2e-26
 Identities = 74/192 (38%), Positives = 104/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +Y++G+    ++   SD  AR+ + Y  +V ++EP VA PH P+N    +E    
Sbjct: 232 DELTLEYVKGRAKREFKVFASDPDARYEAVYEINVEEIEPQVALPHLPENAVPVKEVSGK 291

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+ ED   AA +     GKKVK  V   ++P +Q V+           
Sbjct: 292 DIDQVVIGSCTNGRIEDLRVAAAIL---KGKKVKDYVRCIIIPGSQSVYRQALK------ 342

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF EAG    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E E
Sbjct: 343 --EGLIDIFLEAGA-AVSTPTCGPCLGGHMGILAK---GERAVATTNRNFVGRMGHVESE 396

Query: 538 IYLVSPYTAAAS 573
           +YL  P  AAAS
Sbjct: 397 VYLAGPAVAAAS 408

[97][TOP]
>UniRef100_C8W661 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=C8W661_9FIRM
          Length = 420

 Score =  122 bits (306), Expect = 2e-26
 Identities = 75/193 (38%), Positives = 107/193 (55%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT  Y+EG+   PY    SD  A +    R+D +K+EPLVA PH P+N     +   
Sbjct: 230 PDEITRAYVEGRVKKPYTFYKSDADAVYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGL 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           V++++V IGSCT G+ ED   AA V     GKKV  ++   ++P TQ+++          
Sbjct: 290 VELDQVVIGSCTNGRMEDLRLAAGVL---KGKKVSDRIRLIVIPGTQQIYKQAMR----- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AG    ++P+CG CLGG     A+    +  ++TTNRNF GRMG  E 
Sbjct: 342 ---EGLIEIFIDAG-GAVSTPTCGPCLGGYMGILAK---GERSLATTNRNFVGRMGSPES 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL +P  AAAS
Sbjct: 395 EVYLCNPAVAAAS 407

[98][TOP]
>UniRef100_C0QS35 3-isopropylmalate dehydratase, large subunit n=1 Tax=Persephonella
           marina EX-H1 RepID=C0QS35_PERMH
          Length = 428

 Score =  122 bits (305), Expect = 3e-26
 Identities = 73/192 (38%), Positives = 102/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D    ++L+ KT  P   + +D  A++  EY FD +K+EP+VA P+ P N     E    
Sbjct: 231 DEKVLEWLKDKTDRPLRMLKADPDAKYCCEYEFDASKIEPVVAAPNLPSNVKPVTEVAGK 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            IN+V+IGSCT G+  D   AA +     G+KV   V   ++PA+ +++           
Sbjct: 291 PINQVFIGSCTNGRMSDLRIAAHIL---KGRKVHPDVRCIVIPASDRIYKQALH------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +I  +AGC    S +CG CLGG     A   E +VCVST+NRNF GRMGH   E
Sbjct: 342 --EGILEILADAGCLISTS-TCGPCLGGHMGILA---EGEVCVSTSNRNFTGRMGHPNSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL  P  AAAS
Sbjct: 396 VYLAGPAVAAAS 407

[99][TOP]
>UniRef100_C6PQI2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           carboxidivorans P7 RepID=C6PQI2_9CLOT
          Length = 421

 Score =  122 bits (305), Expect = 3e-26
 Identities = 72/190 (37%), Positives = 105/190 (55%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++  ++  Y    +D+ A +      D++ + P VA PH P+N     E  +V
Sbjct: 231 DDKTIEYVKEHSNREYTVYTADEDAEYSKVIEIDLSSIRPTVAFPHLPENTRTIDEVGEV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            I++  IGSCT G+ ED  AAAKVF  +   K +V   + PATQK++++           
Sbjct: 291 FIDQAVIGSCTNGRIEDLRAAAKVFKGNKVNK-RVRAIIFPATQKIYLEALR-------- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +   +IF EAG    ++P+CG CLGG     A+    +  ++TTNRNF GRMGH E E+Y
Sbjct: 342 EGLLEIFIEAGA-VVSTPTCGPCLGGHMGILAK---GERAIATTNRNFVGRMGHPESEVY 397

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 398 LASPAVAAAS 407

[100][TOP]
>UniRef100_C4CHB6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CHB6_9CHLR
          Length = 418

 Score =  122 bits (305), Expect = 3e-26
 Identities = 80/192 (41%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T ++L   T  PYE V SD  A +L    FDV+ L+P+VA PH P N   A E  D+
Sbjct: 229 DDKTREWLARVTDRPYEPVESDPDAEYLKVIEFDVSNLKPVVALPHLPSNVYPADEVGDM 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+  D    AK+     G++V   V   ++P +Q+V           +
Sbjct: 289 PIHQVVIGSCTNGRISDLREVAKIL---KGRQVHPNVRCIVIPGSQEV--------AKQA 337

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +  + IF EAG     S +CG CLGG     A+    + CVSTTNRNF GRMGHRE E
Sbjct: 338 TREGLADIFLEAGAIFSTS-TCGPCLGGYMGVLAK---GERCVSTTNRNFRGRMGHREAE 393

Query: 538 IYLVSPYTAAAS 573
           I L  P  AAAS
Sbjct: 394 IILAGPQVAAAS 405

[101][TOP]
>UniRef100_Q8U2A1 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           furiosus RepID=LEUC1_PYRFU
          Length = 424

 Score =  122 bits (305), Expect = 3e-26
 Identities = 77/195 (39%), Positives = 109/195 (55%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRA-LARECK 177
           PD  T +Y++G+    Y+   SD+ A++     +DV+K+EP VA PH P+N   +++  K
Sbjct: 231 PDKKTIEYVKGRAKREYKIYKSDEDAKYYKVIEYDVSKIEPQVAFPHLPENTVPISKAAK 290

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPV 348
            ++KI++V IGSCT G+ ED   AA+V     G+KV   V   ++P +  V+        
Sbjct: 291 MNIKIDQVVIGSCTNGRLEDLRMAAEVL---EGQKVAPWVRLIILPCSPTVYFKAMK--- 344

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +   +IF EAG      P+CG CLGG     A     +  VSTTNRNF GRMGH 
Sbjct: 345 -----EGLLEIFLEAGA-VIGPPTCGPCLGGHMGILA---SGERAVSTTNRNFVGRMGHP 395

Query: 529 EGEIYLVSPYTAAAS 573
           + E+YL SPY AAAS
Sbjct: 396 KSEVYLASPYVAAAS 410

[102][TOP]
>UniRef100_A8CU07 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           VS RepID=A8CU07_9CHLR
          Length = 417

 Score =  121 bits (304), Expect = 3e-26
 Identities = 74/191 (38%), Positives = 106/191 (55%), Gaps = 1/191 (0%)
 Frame = +1

Query: 4   DSITYKYLEGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           D  T +YL        Y+ + +D+ A +      D T LEP V+KPH+ DN A ARE K 
Sbjct: 227 DRQTLEYLRSVGREADYQPLAADENAVYERVIEIDATALEPTVSKPHTVDNTATARELKG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
            K+++V+IG+CTGG+ +D   AA +F  +     +    + PA+QKV+++   L      
Sbjct: 287 TKLDQVFIGTCTGGRLDDLAVAAAIF-KNRRHHPQTRLIVTPASQKVYLEAIRLGY---- 341

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +I  +AG +    P CGACLG  +     + + +VC+ST NRNF GRMG+ EG I
Sbjct: 342 ----IEILVQAGANI-MPPGCGACLGVHQGV---LGDGEVCLSTANRNFKGRMGNPEGFI 393

Query: 541 YLVSPYTAAAS 573
           YL S  TAAAS
Sbjct: 394 YLASAATAAAS 404

[103][TOP]
>UniRef100_A5ZAM9 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum
           ATCC 27560 RepID=A5ZAM9_9FIRM
          Length = 421

 Score =  121 bits (304), Expect = 3e-26
 Identities = 74/192 (38%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +Y++  ++  Y    +D+ A +  EY  D++ L P VA PH P+N     E  DV
Sbjct: 231 DDLTIEYMKEHSTKEYTVYEADEDAEYDEEYTIDLSTLRPTVAFPHLPENTRTIDEVGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED   AAK+     G++V   V   + PATQ +++          
Sbjct: 291 KIDQVVIGSCTNGRIEDMRTAAKIL---EGREVAKGVRCIVFPATQAIYLQCIE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +     F +AGC   ++P+CG CLGG     A+    +  V+TTNRNF GRMG  E E
Sbjct: 342 --EGIMTTFIKAGC-AVSTPTCGPCLGGHMGILAK---GERAVATTNRNFVGRMGDPESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[104][TOP]
>UniRef100_B9E370 Putative uncharacterized protein n=1 Tax=Clostridium kluyveri NBRC
           12016 RepID=B9E370_CLOK1
          Length = 426

 Score =  121 bits (303), Expect = 4e-26
 Identities = 73/192 (38%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++  ++  Y    +D+ A ++     D++K+ P VA PH P+N     E  ++
Sbjct: 237 DEKTIEYVKEHSNRSYTVYEADEDAEYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEI 296

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AAKV     G+KV   V T + PATQ +++          
Sbjct: 297 KIDQVVIGSCTNGRIGDLRVAAKVL---KGRKVNSNVRTIIFPATQSIYLQAMK------ 347

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +IF E+G    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E E
Sbjct: 348 --EGLLEIFIESGA-VVSTPTCGPCLGGHMGILAK---GERAVATTNRNFTGRMGHVESE 401

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 402 VYLASPAVAAAS 413

[105][TOP]
>UniRef100_A5MZ75 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           kluyveri DSM 555 RepID=LEUC_CLOK5
          Length = 420

 Score =  121 bits (303), Expect = 4e-26
 Identities = 73/192 (38%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++  ++  Y    +D+ A ++     D++K+ P VA PH P+N     E  ++
Sbjct: 231 DEKTIEYVKEHSNRSYTVYEADEDAEYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AAKV     G+KV   V T + PATQ +++          
Sbjct: 291 KIDQVVIGSCTNGRIGDLRVAAKVL---KGRKVNSNVRTIIFPATQSIYLQAMK------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +IF E+G    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E E
Sbjct: 342 --EGLLEIFIESGA-VVSTPTCGPCLGGHMGILAK---GERAVATTNRNFTGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[106][TOP]
>UniRef100_Q0AV21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Syntrophomonas
           wolfei subsp. wolfei str. Goettingen RepID=Q0AV21_SYNWW
          Length = 419

 Score =  120 bits (302), Expect = 6e-26
 Identities = 72/192 (37%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  Y++ +   P+E   SD  A +     +DV+KLEP+VA PH P+N     E   V
Sbjct: 231 DEITLDYVKKRVKRPFELYQSDPDAVYFDIKEYDVSKLEPVVAFPHLPENTRPVTEATHV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            +++V IGSCT G+ ED    A +     G+KV  ++   + P T++++++         
Sbjct: 291 SLDQVVIGSCTNGRIEDMEITASLL---KGQKVHPEIRVIIFPGTREIYLEALR------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAG    ++P+CG CLGG     AR    +  ++TTNRNF GRMGH E E
Sbjct: 342 --RGYIETFIEAGA-VVSTPTCGPCLGGHMGILAR---GEKALATTNRNFVGRMGHPESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[107][TOP]
>UniRef100_A5FS15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FS15_DEHSB
          Length = 431

 Score =  120 bits (302), Expect = 6e-26
 Identities = 72/191 (37%), Positives = 106/191 (55%), Gaps = 1/191 (0%)
 Frame = +1

Query: 4   DSITYKYLEGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           D  T +YL        Y+ + +D  A +      D T LEP ++KPH+ DN A ARE K 
Sbjct: 241 DRQTLEYLRSVGREADYQPLAADADAVYERVIEIDATALEPTISKPHTVDNTATARELKG 300

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
            K+++V+IG+CTGG+ +D   AA +F  +  +  +    + PA+QK++++   L      
Sbjct: 301 TKLDQVFIGTCTGGRLDDLAVAAAIF-KNRKRHPQTRLIVTPASQKIYLEAIRLGY---- 355

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +I  +AG +    P CGACLG  +     + + +VC+ST NRNF GRMG+ EG I
Sbjct: 356 ----IEILVQAGANI-MPPGCGACLGVHQGV---LGDGEVCLSTANRNFKGRMGNPEGFI 407

Query: 541 YLVSPYTAAAS 573
           YL S  TAAAS
Sbjct: 408 YLASAATAAAS 418

[108][TOP]
>UniRef100_C4FI11 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium yellowstonense SS-5
           RepID=C4FI11_9AQUI
          Length = 431

 Score =  120 bits (302), Expect = 6e-26
 Identities = 73/193 (37%), Positives = 105/193 (54%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +++  +T   ++   SD  A++  EY FD +K+EP+VA P  P N     E   
Sbjct: 230 PDEKTVEWVRKRTDREFKLYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAG 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
             I++V+IGSCT G+  D   AA +     GKKV  +V   ++PA+ +++          
Sbjct: 290 THIDQVFIGSCTNGRLSDLRIAAAIL---KGKKVHPEVRCIVIPASDQIYKQALH----- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +I  EAGC    S +CG CLGG     A   E +VC+ST+NRNF GRMGH + 
Sbjct: 342 ---EGIIEILAEAGCLISTS-TCGPCLGGHMGILA---EGEVCLSTSNRNFVGRMGHPKS 394

Query: 535 EIYLVSPYTAAAS 573
           ++YL SP  AAAS
Sbjct: 395 QVYLSSPAVAAAS 407

[109][TOP]
>UniRef100_A4XJ48 3-isopropylmalate dehydratase large subunit n=1
           Tax=Caldicellulosiruptor saccharolyticus DSM 8903
           RepID=LEUC_CALS8
          Length = 429

 Score =  120 bits (302), Expect = 6e-26
 Identities = 73/193 (37%), Positives = 107/193 (55%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D  T +Y++  ++ PY+   +D+ A +   Y  D++K+ P VA PH P+N     E  + 
Sbjct: 233 DEKTIEYVKQHSTKPYKIFKADEDAEYSEVYEIDISKIRPTVAFPHLPENTKTIDEITEK 292

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           + I++V IGSCT G+ ED   AAK+     G+KVK  +   + PATQ ++          
Sbjct: 293 IYIDQVVIGSCTNGRIEDLRIAAKILK---GRKVKKGLRCIIFPATQNIYKQALK----- 344

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AGC   ++P+CG CLGG     A   E +  ++TTNRNF GRMGH   
Sbjct: 345 ---EGLIEIFIDAGC-VVSTPTCGPCLGGHMGILA---EGERALATTNRNFVGRMGHPNS 397

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 398 EVYLSSPAIAAAS 410

[110][TOP]
>UniRef100_B8I4G0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I4G0_CLOCE
          Length = 419

 Score =  120 bits (301), Expect = 7e-26
 Identities = 73/192 (38%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++  +   Y    +D+ A +   Y  D+ +++P VA PH P+N        D+
Sbjct: 231 DEKTVEYVKEHSIRHYTVYKADEDAEYSEVYEIDLAEVKPTVAFPHLPENARTIDNVGDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+ ED   AA V     G+KV   V   ++PATQK+W    +      
Sbjct: 291 KIDQVVIGSCTNGRIEDMRIAAGVL---KGRKVSDNVRCIIIPATQKIWKQAMN------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG    ++P+CG CLGG     A+    +  V+TTNRNF GRMGH E E
Sbjct: 342 --EGLFDIFIDAGA-AVSTPTCGPCLGGHMGILAK---GERAVATTNRNFVGRMGHPESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL  P  AAAS
Sbjct: 396 VYLAGPAVAAAS 407

[111][TOP]
>UniRef100_A8SZ55 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SZ55_9FIRM
          Length = 461

 Score =  120 bits (301), Expect = 7e-26
 Identities = 72/192 (37%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +Y++  ++  Y    +D+ A + +EY  D+++L+P VA PH P+N     E  D+
Sbjct: 271 DELTEEYMKEHSTKSYTKYEADEDAVYDAEYTIDLSQLKPTVAFPHLPENTKTIDEVGDI 330

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AA +     G+KV   V   ++P TQ +++          
Sbjct: 331 KIDQVVIGSCTNGRISDMRIAADII---KGRKVADGVRVIVIPGTQDIYLQCIE------ 381

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG    ++P+CG CLGG       M   +  VSTTNRNF GRMGH + E
Sbjct: 382 --EGLMTIFVKAGA-VVSTPTCGPCLGGHMGV---MAAGERAVSTTNRNFVGRMGHVDSE 435

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 436 VYLASPAVAAAS 447

[112][TOP]
>UniRef100_C6PDK3 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571
           RepID=C6PDK3_CLOTS
          Length = 418

 Score =  120 bits (300), Expect = 1e-25
 Identities = 72/192 (37%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  Y++G+ +  Y+   +D+ A ++  Y  D++K++P VA PH P+N     E  ++
Sbjct: 229 DEITETYVKGRANRKYKVFKADKDADYVESYDIDLSKIKPQVAFPHLPENTKPIDEVGNI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D     +V     GKKV   V   + PATQ ++++         
Sbjct: 289 KIDQVVIGSCTNGRISDMEVTYEVL---KGKKVHPDVRLIIFPATQDIYLECVK------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F +AG    ++P+CG CLGG     A+    +  +STTNRNF GRMGH E E
Sbjct: 340 --RGYIEEFIKAGA-AVSTPTCGPCLGGHMGILAK---DERAISTTNRNFVGRMGHTESE 393

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 394 VYLASPAVAAAS 405

[113][TOP]
>UniRef100_C0FIT9 Putative uncharacterized protein n=1 Tax=Clostridium sp. M62/1
           RepID=C0FIT9_9CLOT
          Length = 278

 Score =  120 bits (300), Expect = 1e-25
 Identities = 73/192 (38%), Positives = 106/192 (55%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D    +Y++  +   ++   +D+ A + + Y  D++ L+P VA PH P+N     E  DV
Sbjct: 88  DEKAVQYMKEHSKREFQIHEADEDAEYEAVYTIDLSALKPTVAFPHLPENTKTIDEAGDV 147

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+ ED   AA++     G+KVK  V   ++PATQ +++          
Sbjct: 148 AIDQVVIGSCTNGRLEDMRIAAEIL---KGRKVKKGVRCIVIPATQAIYLQCIK------ 198

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAG    ++P+CG CLGG     A     + CVSTTNRNF GRMGH + E
Sbjct: 199 --EGLMETFIEAGA-VVSTPTCGPCLGGYMGILA---AGERCVSTTNRNFVGRMGHVDSE 252

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 253 VYLASPAVAAAS 264

[114][TOP]
>UniRef100_C0CLF7 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CLF7_9FIRM
          Length = 422

 Score =  120 bits (300), Expect = 1e-25
 Identities = 72/193 (37%), Positives = 108/193 (55%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKD 180
           D +   Y+   +   ++   +D+ A +  EY  D+++L+P +A PH P+N R +     D
Sbjct: 231 DDLAVAYMREHSKREFKIYEADEDAVYEEEYTIDLSQLKPTIAFPHLPENTRTIDEITAD 290

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           V I++  IGSCT G+ ED   AA++     G+KVK  +   ++PATQ +++         
Sbjct: 291 VVIDQSVIGSCTNGRMEDLRIAAEILK---GRKVKKGIRCIVIPATQAIYLQAMK----- 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF EAG    ++P+CG CLGG     A   E + C+STTNRNF GRMGH + 
Sbjct: 343 ---EGLLEIFIEAGA-VVSTPTCGPCLGGYMGILA---EGERCISTTNRNFVGRMGHVDS 395

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 396 EVYLASPAVAAAS 408

[115][TOP]
>UniRef100_P81291 Isopropylmalate/citramalate isomerase large subunit n=1
           Tax=Methanocaldococcus jannaschii RepID=LEUC_METJA
          Length = 424

 Score =  120 bits (300), Expect = 1e-25
 Identities = 72/195 (36%), Positives = 101/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T +Y++       T  P+E +  D+ A F   Y  +  K+EP+ A PH+ DN   A
Sbjct: 229 PDEKTIQYVKEAMKKHGTERPFEVIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKQA 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED   A K+    GG    V   + PA+++ ++      
Sbjct: 289 REVAGKPIDQVFIGSCTNGRLEDLRMAIKIIEKHGGIADDVRVVVTPASREEYLKALK-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +VCVST+NRNF GR G 
Sbjct: 347 ------EGIIEKFLKYGC-VVTNPSCSACMG---SLYGVLGPGEVCVSTSNRNFRGRQGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E EIYL SP TAAA
Sbjct: 397 LEAEIYLASPITAAA 411

[116][TOP]
>UniRef100_Q3ZZK0 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           CBDB1 RepID=Q3ZZK0_DEHSC
          Length = 417

 Score =  119 bits (299), Expect = 1e-25
 Identities = 68/175 (38%), Positives = 101/175 (57%)
 Frame = +1

Query: 49  YESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKT 228
           Y+ + +D  A +      D T LEP ++KPH+ DN A ARE K  K+++V+IG+CTGG+ 
Sbjct: 243 YQPLAADVDAVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFIGTCTGGRL 302

Query: 229 EDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTP 408
           +D   AA +F  +  +  +    + PA+QK++++   L           +I  +AG +  
Sbjct: 303 DDLAVAAAIF-KNRKRHPQTRLIVTPASQKIYLEAIRLGY--------IEILVQAGANI- 352

Query: 409 ASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
             P CGACLG  +     + + +VC+ST NRNF GRMG+ EG IYL S  TAAAS
Sbjct: 353 MPPGCGACLGVHQGV---LGDGEVCLSTANRNFKGRMGNPEGFIYLASAATAAAS 404

[117][TOP]
>UniRef100_Q24XT4 3-isopropylmalate dehydratase large subunit n=2
           Tax=Desulfitobacterium hafniense RepID=LEUC_DESHY
          Length = 421

 Score =  119 bits (299), Expect = 1e-25
 Identities = 73/193 (37%), Positives = 103/193 (53%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y+  +   PY+  +SD  A+++  Y +DV  +   VA PH P+N     E K 
Sbjct: 231 PDEKTLAYVNERAKRPYKVYHSDPDAQYVEVYEWDVADIPLQVAFPHLPENAKPVSEGKG 290

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           +KI++V IGSCT G+ ED   AA++     G+KV   V   ++P TQ ++          
Sbjct: 291 IKIDQVVIGSCTNGRLEDMQVAAQIL---KGQKVHGDVRLIVIPGTQDIYKQAMQ----- 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF +AG    ++P+CG CLGG     A+    +  +STTNRNF GRMGH E 
Sbjct: 343 ---EGLIDIFIDAGA-VVSTPTCGPCLGGYMGILAK---GERALSTTNRNFVGRMGHPES 395

Query: 535 EIYLVSPYTAAAS 573
           E+YL  P  AAAS
Sbjct: 396 EVYLSGPAVAAAS 408

[118][TOP]
>UniRef100_A9BGP4 3-isopropylmalate dehydratase, large subunit n=1 Tax=Petrotoga
           mobilis SJ95 RepID=A9BGP4_PETMO
          Length = 419

 Score =  119 bits (299), Expect = 1e-25
 Identities = 76/192 (39%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL+ +    Y  V SD  A +     +DV+ +EP VA PH P+N     E K +
Sbjct: 229 DEKTKEYLKERAVRDYTPVSSDPDASYEEVIEYDVSNIEPQVAFPHLPENTKPVTEAKRI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++  IGSCT G+ ED   AA V     G KV   V   + P TQ ++M          
Sbjct: 289 KIDQSVIGSCTNGRIEDLRIAAHVL---KGHKVNSDVRCIIFPGTQDIYMQALK------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +IF EAG    ++P+CG CLGG     A+    +  +STTNRNF GRMGH E E
Sbjct: 340 --EGLIEIFIEAGA-AVSTPTCGPCLGGHMGVLAK---GEKAISTTNRNFVGRMGHPESE 393

Query: 538 IYLVSPYTAAAS 573
           +YL +P  AAAS
Sbjct: 394 VYLSNPAVAAAS 405

[119][TOP]
>UniRef100_C9LTJ0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Selenomonas
           sputigena ATCC 35185 RepID=C9LTJ0_9FIRM
          Length = 420

 Score =  119 bits (298), Expect = 2e-25
 Identities = 72/191 (37%), Positives = 102/191 (53%), Gaps = 1/191 (0%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D  T +Y+EG+    YE V SD  A++      D++ L P+VA PH P N     +  + 
Sbjct: 230 DEKTKEYVEGRVKGAYEPVTSDADAKYCRTVEIDLSSLRPVVAFPHLPGNTKRVMDIAEP 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           +KI++V IGSCT G+ ED   +A + L        V   ++P +Q V+ +   L      
Sbjct: 290 IKIDQVVIGSCTNGRLEDLEISAGL-LKGHEVHPDVRCIVIPGSQAVYQEAMHLGY---- 344

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                 +F +AGC   A+P+CG CLGG       +   + CVSTTNRNF GRMGH + E+
Sbjct: 345 ----IDVFIDAGCAV-AAPTCGPCLGGYMGI---LTAGERCVSTTNRNFRGRMGHVDSEV 396

Query: 541 YLVSPYTAAAS 573
           YL  P+ AAAS
Sbjct: 397 YLAGPHVAAAS 407

[120][TOP]
>UniRef100_C9KJM7 3-isopropylmalate dehydratase, large subunit n=2 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KJM7_9FIRM
          Length = 420

 Score =  119 bits (298), Expect = 2e-25
 Identities = 72/193 (37%), Positives = 106/193 (54%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D IT  Y++ + + PYE V +D  A +  E   ++++L+P+VA PH P N     + K+ 
Sbjct: 230 DEITKAYVDARVTKPYEPVAADDDAEYCREVDINLSELKPVVAFPHLPGNTKRVEDIKEP 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           ++I++V IGSCT G+ ED   AA +     G KV  +V   ++P +  ++ +        
Sbjct: 290 IEIDQVIIGSCTNGRLEDMEIAASILK---GHKVADRVRCIVIPGSPAIYKE-------- 338

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
           S  +     F +AGC   ++P+CG CLGG     A       CVSTTNRNF GRMGH + 
Sbjct: 339 SMKRGYIDTFIDAGCAV-STPTCGPCLGGYMGIMAAGER---CVSTTNRNFRGRMGHVDS 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL  P  AAAS
Sbjct: 395 EVYLAGPQVAAAS 407

[121][TOP]
>UniRef100_A9KT79 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           phytofermentans ISDg RepID=LEUC_CLOPH
          Length = 421

 Score =  119 bits (298), Expect = 2e-25
 Identities = 73/192 (38%), Positives = 104/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y++   + PY    +D+ A +      ++++LEP VA PH P+N    +E  +V
Sbjct: 231 DDLTISYMKEHGAKPYTIYEADEDAEYEQIITINLSELEPTVAFPHLPENTKTVKEAGEV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           +I++V IGSCT G+  D   AAKV     G+KV   +   + PATQ +++          
Sbjct: 291 RIDQVVIGSCTNGRIGDLRIAAKVL---EGRKVAKGMRAIVFPATQAIYLQAIE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   Q F +AGC   ++P+CG CLGG     A     +   STTNRNF GRMGH E E
Sbjct: 342 --EGLIQTFIKAGC-VVSTPTCGPCLGGHMGILA---AGERAASTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLCSPAVAAAS 407

[122][TOP]
>UniRef100_C8WM14 3-isopropylmalate dehydratase, large subunit n=2 Tax=Eggerthella
           lenta DSM 2243 RepID=C8WM14_9ACTN
          Length = 422

 Score =  119 bits (297), Expect = 2e-25
 Identities = 72/190 (37%), Positives = 96/190 (50%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  YL+G+T  PY   +SD  A +   Y  D   + P V+ PH P N   A E +DV
Sbjct: 233 DDVTRAYLDGRTERPYTEYHSDADATYAKVYEIDAASIVPTVSFPHLPSNTRPAAEARDV 292

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI++  IGSCT G+  D   AA V L        V   ++PATQ V+             
Sbjct: 293 KIDQAVIGSCTNGRIADMRQAADV-LRGRTVHPDVRCIVIPATQAVYRQCME-------- 343

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +    +F +A C   ++P+CG CLGG     A     +  ++TTNRNF GRMG    E+Y
Sbjct: 344 EGLMDVFLDANC-AVSTPTCGPCLGGYMGILA---AGERAIATTNRNFVGRMGDPTSEVY 399

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 400 LSSPAIAAAS 409

[123][TOP]
>UniRef100_A6UTQ6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           aeolicus Nankai-3 RepID=A6UTQ6_META3
          Length = 425

 Score =  119 bits (297), Expect = 2e-25
 Identities = 70/178 (39%), Positives = 97/178 (54%)
 Frame = +1

Query: 37  TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCT 216
           T+ PY ++  D+ A+F   Y  +V  LEPL A PH+ DN   ARE     I++V+IGSCT
Sbjct: 247 TTRPYTALKGDEDAKFEETYEIEVNDLEPLFACPHAVDNVKTAREVAGRPIDQVFIGSCT 306

Query: 217 GGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAG 396
            G+ ED  AA  +    GG    V   + PA+++V ++  +        +   Q F E G
Sbjct: 307 NGRVEDLRAAINIIDQHGGIADDVRVVVTPASREVMLEAIN--------EGIIQKFYEYG 358

Query: 397 CDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAA 570
           C    +PSC AC+G     Y  +   +V V+T+NRNF GR G  E E+YL SP TAAA
Sbjct: 359 C-VVTNPSCSACMGA---LYGILGPNEVGVATSNRNFRGREGSLESEVYLASPITAAA 412

[124][TOP]
>UniRef100_C9RGT8 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           vulcanius M7 RepID=C9RGT8_9EURY
          Length = 422

 Score =  119 bits (297), Expect = 2e-25
 Identities = 71/195 (36%), Positives = 101/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T +Y++       T  P+E +  D+ A F   Y  +  K+EP+ A PH+ DN   A
Sbjct: 227 PDEKTIQYVKEAMKKHGTERPFEIIKGDEDAEFEEVYEIEADKIEPVFACPHNVDNVKQA 286

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED   A +V    GG    +   + PA+++ ++      
Sbjct: 287 REVAGRPIDQVFIGSCTNGRVEDLRMAIEVIEKHGGIADNIRVIITPASREEYLKALK-- 344

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +VCVST+NRNF GR G 
Sbjct: 345 ------EGIIEKFLKYGC-VVTNPSCSACMG---SLYGVLGPGEVCVSTSNRNFRGRQGS 394

Query: 526 REGEIYLVSPYTAAA 570
            E EIYL SP TAAA
Sbjct: 395 LEAEIYLASPITAAA 409

[125][TOP]
>UniRef100_Q6LY44 3-isopropylmalate dehydratase n=1 Tax=Methanococcus maripaludis
           RepID=Q6LY44_METMP
          Length = 424

 Score =  118 bits (296), Expect = 3e-25
 Identities = 68/195 (34%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T  Y++       T+ P+E V  D+ A F  ++  DV+ LEP++A PH+ DN    
Sbjct: 229 PDDKTINYVKNAMEANNTAKPFELVLGDKNAEFEEKFEIDVSNLEPVMACPHNVDNVKAV 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED  AA  V    GG    +   + PA++ + ++     
Sbjct: 289 REVAGTPIDQVFIGSCTNGRLEDLRAALNVIEKHGGISKDIRVVVTPASRSIMLEAID-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +V ++T+NRNF GR G 
Sbjct: 347 ------EGLIKKFYQYGC-VVTNPSCSACMGA---LYGLLGPGEVGIATSNRNFRGREGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E ++YL SP TAAA
Sbjct: 397 LESDVYLASPITAAA 411

[126][TOP]
>UniRef100_A4FX22 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanococcus
           maripaludis C5 RepID=A4FX22_METM5
          Length = 424

 Score =  118 bits (296), Expect = 3e-25
 Identities = 67/195 (34%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T  Y++       T+ P+E +  D+ A F  ++  DV+ LEP++A PH+ DN    
Sbjct: 229 PDDKTINYVKNAMEMNNTAKPFEFILGDKDAEFEKKFEIDVSNLEPVMACPHNVDNVKAV 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED  AA +V    GG    +   + PA++ + ++     
Sbjct: 289 REVAGTPIDQVFIGSCTNGRLEDLRAALEVIEKHGGISKDIRVVVTPASRSIMLEAID-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +V ++T+NRNF GR G 
Sbjct: 347 ------EGLIKKFYQYGC-VVTNPSCSACMGA---LYGLLGPGEVGIATSNRNFRGREGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E ++YL SP TAAA
Sbjct: 397 LESDVYLASPITAAA 411

[127][TOP]
>UniRef100_A0B7A3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosaeta
           thermophila PT RepID=A0B7A3_METTP
          Length = 382

 Score =  118 bits (296), Expect = 3e-25
 Identities = 67/191 (35%), Positives = 109/191 (57%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD     YL  +   PY  ++SD  + +  E  +DV+ + P++A P+  DN    R+   
Sbjct: 197 PDESVDAYLARRARRPYTHIHSDPGS-YYREIEYDVSDIPPMIAAPYRVDNVHPVRDLAG 255

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           +++++V+IG+CT G+ ED   AA++     GK+VK+ T ++PA++++++        G+ 
Sbjct: 256 IEVDQVFIGTCTNGRLEDLEMAARIV---KGKRVKIRTLVIPASREIYL--------GAL 304

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +   EAG      P CG CLG        + + +VC+ST+NRNFPGRMG R G++
Sbjct: 305 RSGVIETLVEAGA-MIGPPGCGPCLGAHMGV---LGDGEVCLSTSNRNFPGRMG-RNGKV 359

Query: 541 YLVSPYTAAAS 573
           YL SP TAAA+
Sbjct: 360 YLASPATAAAT 370

[128][TOP]
>UniRef100_A0LMK9 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMK9_SYNFM
          Length = 419

 Score =  118 bits (295), Expect = 4e-25
 Identities = 76/193 (39%), Positives = 102/193 (52%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD +T +Y++G+    YE   SD  A F S + +DV+  EP+VA PHSP N         
Sbjct: 230 PDPVTEEYVKGRAKRSYEFYRSDPDAAFESVHEWDVSAFEPMVALPHSPANVRPVSRIPR 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
             I++V IGSCT G+ ED   AA +     G+KV   V   ++PAT++++          
Sbjct: 290 TVIDQVVIGSCTNGRYEDLETAAAIL---KGRKVAPGVRCMIIPATREIYRQAL------ 340

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
             G   + +  EA   T   P+CG CLGG     A     +  V+TTNRNF GRMGH E 
Sbjct: 341 RNGLLETFVDAEAAVST---PTCGPCLGGHMGILA---AGEKAVATTNRNFLGRMGHAES 394

Query: 535 EIYLVSPYTAAAS 573
           EIYL +P  AAAS
Sbjct: 395 EIYLSNPAVAAAS 407

[129][TOP]
>UniRef100_A6VG92 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C7 RepID=A6VG92_METM7
          Length = 424

 Score =  118 bits (295), Expect = 4e-25
 Identities = 68/195 (34%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T  Y++       T+ P+E +  D+ A F  ++  +V  LEP++A PH+ DN    
Sbjct: 229 PDDKTINYVKNAMETNNTAKPFEFILGDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKTV 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED  AA KV    GG    +   + PA++ V ++     
Sbjct: 289 REVAGTPIDQVFIGSCTNGRIEDLRAALKVIEKHGGISKDIRVVVTPASRSVMLEAID-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +V ++T+NRNF GR G 
Sbjct: 347 ------EGLIKKFYQYGC-VVTNPSCSACMGA---LYGLLGPGEVGIATSNRNFRGREGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E ++YL SP TAAA
Sbjct: 397 LESDVYLASPITAAA 411

[130][TOP]
>UniRef100_C7P7J9 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           fervens AG86 RepID=C7P7J9_METFA
          Length = 424

 Score =  118 bits (295), Expect = 4e-25
 Identities = 71/195 (36%), Positives = 101/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T +Y++       T  P+E +  D+ A F   Y  +  K+EP+ A PH+ DN   A
Sbjct: 229 PDEKTVQYVKEAMKKHGTERPFEIIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKPA 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED   A ++    GG    V   + PA+++ ++      
Sbjct: 289 REVAGRPIDQVFIGSCTNGRFEDLKMAIEIIDKHGGIADNVRVVVTPASREEYLKALKAG 348

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
           +         + F + GC    +PSC AC+G     Y  +   +VCVST+NRNF GR G 
Sbjct: 349 I--------IEKFLKYGC-VVTNPSCSACMG---SLYGVLGPGEVCVSTSNRNFRGRQGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E EIYL SP TAAA
Sbjct: 397 LEAEIYLASPITAAA 411

[131][TOP]
>UniRef100_B9MLV4 3-isopropylmalate dehydratase large subunit n=1 Tax=Anaerocellum
           thermophilum DSM 6725 RepID=LEUC_ANATD
          Length = 429

 Score =  118 bits (295), Expect = 4e-25
 Identities = 71/193 (36%), Positives = 107/193 (55%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D  T +Y++  ++ PY+   +D+ A +   +  D++K+ P VA PH P+N     E  + 
Sbjct: 233 DEKTIEYVKQHSTKPYKIFKADEDAEYSQVFEIDISKIRPTVAFPHLPENTKTIDEITEK 292

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           + I++V IGSCT G+ ED   AAK+     G+KVK  +   + PATQ ++          
Sbjct: 293 IYIDQVVIGSCTNGRIEDLRIAAKILK---GRKVKKGLRCIIFPATQNIYKQALK----- 344

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AGC   ++P+CG CLGG     A   + +  ++TTNRNF GRMGH   
Sbjct: 345 ---EGFIEIFIDAGC-VVSTPTCGPCLGGHMGILA---DGEKALATTNRNFVGRMGHPNS 397

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 398 EVYLSSPAIAAAS 410

[132][TOP]
>UniRef100_C1DUH4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium azorense Az-Fu1
           RepID=C1DUH4_SULAA
          Length = 431

 Score =  117 bits (294), Expect = 5e-25
 Identities = 71/192 (36%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +++  +T+  ++   SD  A++  EY FD  K+EP+VA P+ P N     E    
Sbjct: 231 DEKTIEWVRKRTNREFKIYKSDPDAKYCCEYEFDANKIEPVVACPNLPSNVKPVSEVAGT 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            I++V+IGSCT G+  D   AA +     GKKV  +V   ++PA+ +++           
Sbjct: 291 HIDQVFIGSCTNGRLSDLRIAAAIL---KGKKVHPEVRCIVIPASDQIYKQALH------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +I  +AGC    S +CG CLGG     A   E +VC+ST+NRNF GRMGH + +
Sbjct: 342 --EGIIEILADAGCLISTS-TCGPCLGGHMGILA---EGEVCLSTSNRNFVGRMGHPKSQ 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLSSPAVAAAS 407

[133][TOP]
>UniRef100_B5ICW8 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5ICW8_9EURY
          Length = 419

 Score =  117 bits (294), Expect = 5e-25
 Identities = 78/196 (39%), Positives = 107/196 (54%), Gaps = 5/196 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 177
           PD+ T KYLE       Y  + SD  A F  EY F+V +LEP V+ PH+ DN     E K
Sbjct: 226 PDATTKKYLEEMGRGEKYREIKSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAK 285

Query: 178 --DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLP 345
             +++I++VYIG+CT G+ ED   AAK+     G KV  K    ++PA+++V++      
Sbjct: 286 KMNIRIDQVYIGTCTNGRIEDLRVAAKIL---DGNKVNKKTRLIVIPASRRVYIQALK-- 340

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F EAG     SP CG C+G  K   A   + +  +ST NRNF GRMG+
Sbjct: 341 ------EGLLEKFVEAGA-AIESPGCGPCVGIHKGVLA---DGERVLSTQNRNFKGRMGN 390

Query: 526 REGEIYLVSPYTAAAS 573
              EIYL SP TAAA+
Sbjct: 391 PNAEIYLGSPATAAAT 406

[134][TOP]
>UniRef100_B1QZX5 3-isopropylmalate dehydratase, large subunit n=2 Tax=Clostridium
           butyricum RepID=B1QZX5_CLOBU
          Length = 419

 Score =  117 bits (293), Expect = 6e-25
 Identities = 72/192 (37%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL+      ++   +D+ A++   Y  D++ L P V+ PH PDN        DV
Sbjct: 231 DEKTEEYLKDHAKREWKKYEADEDAQYDEVYEIDLSTLRPTVSFPHLPDNTRTIDNTGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   A  +     GKKV   +   ++P TQK+++          
Sbjct: 291 KIDQVVIGSCTNGRISDLRVARDIL---KGKKVDKTIRCIVIPGTQKIYLQALE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +   EAG    ++P+CG CLGG     A+    + CVSTTNRNF GRMGH E E
Sbjct: 342 --EGIIKDLIEAGA-IVSTPTCGPCLGGHMGILAK---DERCVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[135][TOP]
>UniRef100_A7VIP8 Putative uncharacterized protein n=1 Tax=Clostridium sp. L2-50
           RepID=A7VIP8_9CLOT
          Length = 441

 Score =  117 bits (293), Expect = 6e-25
 Identities = 72/192 (37%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y++  ++  Y+   +D  A +  EY  D++ L P VA PH P+N     E  D+
Sbjct: 251 DELTEAYMKEHSTKAYKKYEADADAVYDEEYTIDLSTLRPTVAFPHLPENTKTIDEVGDI 310

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AA +     G++V   V   ++P TQ+V++          
Sbjct: 311 KIDQVVIGSCTNGRISDMRIAADII---KGRQVAPGVRVIVIPGTQEVYLQCIE------ 361

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG    ++P+CG CLGG       M   +  VSTTNRNF GRMGH + E
Sbjct: 362 --EGLMTIFVKAGA-VVSTPTCGPCLGGHMGV---MAAGERAVSTTNRNFVGRMGHVDSE 415

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 416 VYLASPAVAAAS 427

[136][TOP]
>UniRef100_A8AB09 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ignicoccus
           hospitalis KIN4/I RepID=A8AB09_IGNH4
          Length = 419

 Score =  117 bits (293), Expect = 6e-25
 Identities = 74/192 (38%), Positives = 104/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T K+ E +  +  +    D  A++   + FDV+KLEP VA PHS DN     E +  
Sbjct: 231 DEVTVKFFE-EAGISVKPFGPDPGAQYEDVWEFDVSKLEPQVAVPHSVDNVVAVGEVEGT 289

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++ +IGSCT G+ EDF+ AAK+     G+KV   V    +PA+ K +M +        
Sbjct: 290 PIDQAFIGSCTNGRYEDFVEAAKIL---KGRKVAPGVRCIAIPASLKQYMRLLK------ 340

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    I  EAGC   A  +CG CLGG       +   +V +S++NRNF GRMGH E +
Sbjct: 341 --EGIIDILTEAGCFV-AHSTCGPCLGGHLGV---LGPGEVAISSSNRNFKGRMGHPESK 394

Query: 538 IYLVSPYTAAAS 573
           +YL SP T AAS
Sbjct: 395 VYLASPATVAAS 406

[137][TOP]
>UniRef100_B5IBC4 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IBC4_9EURY
          Length = 419

 Score =  117 bits (293), Expect = 6e-25
 Identities = 78/196 (39%), Positives = 107/196 (54%), Gaps = 5/196 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 177
           PD+ T KYLE       Y  + SD  A F  EY F+V +LEP V+ PH+ DN     E K
Sbjct: 226 PDATTKKYLEEMGRGDKYREIKSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAK 285

Query: 178 --DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLP 345
             +++I++VYIG+CT G+ ED   AAK+     G KV  K    ++PA+++V++      
Sbjct: 286 KMNIRIDQVYIGTCTNGRIEDLRVAAKIL---DGNKVNKKTRLIVIPASRRVYIQALK-- 340

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F EAG     SP CG C+G  K   A   + +  +ST NRNF GRMG+
Sbjct: 341 ------EGLLEKFVEAGA-AIESPGCGPCVGIHKGVLA---DGERVLSTQNRNFKGRMGN 390

Query: 526 REGEIYLVSPYTAAAS 573
              EIYL SP TAAA+
Sbjct: 391 PNAEIYLGSPATAAAT 406

[138][TOP]
>UniRef100_B2V844 3-isopropylmalate dehydratase large subunit n=1
           Tax=Sulfurihydrogenibium sp. YO3AOP1 RepID=LEUC_SULSY
          Length = 431

 Score =  117 bits (293), Expect = 6e-25
 Identities = 70/191 (36%), Positives = 103/191 (53%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  ++  +T+  ++   SD  A++  EY FD +K+EP+VA P  P N     E   
Sbjct: 230 PDEKTVDWVRKRTNREFKLYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAG 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             I++V+IGSCT G+  D   AA + L S     +V   ++PA+ +++            
Sbjct: 290 THIDQVFIGSCTNGRLSDLRIAAAI-LKSKKVHPEVRCIVIPASDQIYKQALH------- 341

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   +I  +AGC    S +CG CLGG     A   E +VC+ST+NRNF GRMGH + ++
Sbjct: 342 -EGIIEILADAGCLISTS-TCGPCLGGHMGILA---EGEVCLSTSNRNFVGRMGHPKSQV 396

Query: 541 YLVSPYTAAAS 573
           YL SP  AAAS
Sbjct: 397 YLSSPAVAAAS 407

[139][TOP]
>UniRef100_C4GAI7 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4GAI7_9FIRM
          Length = 434

 Score =  117 bits (292), Expect = 8e-25
 Identities = 69/172 (40%), Positives = 99/172 (57%), Gaps = 2/172 (1%)
 Frame = +1

Query: 64  SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMA 243
           +D  A + +EY  D++ L+P V+ PH P+N     + +D+ I++V IGSCT G+  D  A
Sbjct: 265 ADADADYAAEYTIDLSSLKPTVSFPHLPENTRTIDQIEDIAIDQVVIGSCTNGRLSDLKA 324

Query: 244 AAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTPASP 417
           AA++     G+KV  +V T ++PATQ++++D               + F EAG    ++P
Sbjct: 325 AAEIL---KGRKVADRVRTIIIPATQQIYLDAMQAGY--------LKTFIEAGA-VVSTP 372

Query: 418 SCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
           +CG CLGG     A     + CVSTTNRNF GRMG    E+YL SP  AAAS
Sbjct: 373 TCGPCLGGYMGILA---AGERCVSTTNRNFVGRMGDVTSEVYLASPAVAAAS 421

[140][TOP]
>UniRef100_A1HRB1 3-isopropylmalate dehydratase n=1 Tax=Thermosinus carboxydivorans
           Nor1 RepID=A1HRB1_9FIRM
          Length = 417

 Score =  117 bits (292), Expect = 8e-25
 Identities = 71/193 (36%), Positives = 106/193 (54%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT +YL+ K    YE  ++D   ++ +E+ FDV+ L+P VA PHS DN     E   
Sbjct: 226 PDEITLEYLKDKVKGDYEIFHTDPGYQYAAEHTFDVSGLKPQVAAPHSVDNVHDITEYIG 285

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVPG 354
             + + ++G+CTGG+ +D   AAK+     GKKV   T   +VPA++ V+++        
Sbjct: 286 RPVQQAFLGTCTGGRVQDLAVAAKIL---KGKKVHPRTRFIVVPASKAVFLEAME----- 337

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              K   Q   EAG  T  +P C ACLG  +   A     + C++ ++RNFPGRMGH + 
Sbjct: 338 ---KGYIQTLVEAGA-TFVTPGCAACLGTHQGMLA---AGETCITASSRNFPGRMGHTKA 390

Query: 535 EIYLVSPYTAAAS 573
           EI++ SP   AA+
Sbjct: 391 EIFIGSPAAVAAA 403

[141][TOP]
>UniRef100_A5IJM1 3-isopropylmalate dehydratase, large subunit n=2 Tax=Thermotogaceae
           RepID=A5IJM1_THEP1
          Length = 417

 Score =  116 bits (291), Expect = 1e-24
 Identities = 73/194 (37%), Positives = 105/194 (54%), Gaps = 4/194 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D IT  Y E +  +  E +Y D+ A+++ E   D+++LEP VA P  P N     E +  
Sbjct: 228 DEITIAY-ERERGIEVEEMYPDEDAKYVREVEMDLSELEPQVAYPFLPSNAKDVSEAEKE 286

Query: 181 -VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVP 351
            +KI++  IGSCT G+ ED   AA++     G+ V   V   ++P +QKV+         
Sbjct: 287 RIKIDQAVIGSCTNGRIEDLRLAAQILK---GRTVSPDVRCIIIPGSQKVYKQALK---- 339

Query: 352 GSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
               +    IF +AGC   ++P+CG CLGG     A   E +V +STTNRNF GRMGH  
Sbjct: 340 ----EGLIDIFIDAGCAV-STPTCGPCLGGHMGVLA---EGEVAISTTNRNFVGRMGHPN 391

Query: 532 GEIYLVSPYTAAAS 573
            +++L SP  AAAS
Sbjct: 392 SKVFLASPAVAAAS 405

[142][TOP]
>UniRef100_Q0W1Q4 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W1Q4_UNCMA
          Length = 414

 Score =  116 bits (291), Expect = 1e-24
 Identities = 71/191 (37%), Positives = 101/191 (52%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+ +L+G+    Y  VY+ + A +  E   DV+KL P V+ P   DN     E + 
Sbjct: 227 PDEKTFAFLKGRAVEEYRPVYASRDAVYCDELHLDVSKLHPQVSCPPDVDNVKDVGEVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++V IGSCT G+ ED   AA +     G+KV+  T ++PA++ V +D     V    
Sbjct: 287 THVDQVLIGSCTNGRYEDLAGAAAIL---KGRKVRCRTLIIPASRSVMLDAVQTGVAAD- 342

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                     AG  T  +P CG CLGG     A   E + C++TTNRNF GRMG +  ++
Sbjct: 343 -------LLAAGA-TICNPGCGPCLGGHMGVLA---EGEACLATTNRNFRGRMG-KGADV 390

Query: 541 YLVSPYTAAAS 573
           YL SP TAAA+
Sbjct: 391 YLGSPLTAAAT 401

[143][TOP]
>UniRef100_A9AAG0 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C6 RepID=A9AAG0_METM6
          Length = 424

 Score =  116 bits (291), Expect = 1e-24
 Identities = 67/195 (34%), Positives = 101/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T  Y++       T+ P+E +  D+ A F  ++  +V  LEP++A PH+ DN    
Sbjct: 229 PDDKTINYVKNAMETNNTAKPFEFILGDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKAV 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED  AA  V    GG    +   + PA++ V ++     
Sbjct: 289 REVAGTPIDQVFIGSCTNGRIEDLRAALNVIEKHGGISKDIRVVVTPASRSVMLEAID-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +V ++T+NRNF GR G 
Sbjct: 347 ------EGLIKKFYQYGC-VVTNPSCSACMGA---LYGLLGSGEVGIATSNRNFRGREGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E ++YL SP TAAA
Sbjct: 397 LESDVYLASPITAAA 411

[144][TOP]
>UniRef100_A2SR25 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanocorpusculum labreanum Z RepID=A2SR25_METLZ
          Length = 392

 Score =  116 bits (291), Expect = 1e-24
 Identities = 72/191 (37%), Positives = 102/191 (53%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T++Y+ G+T V   S+ SD+ A F     +D+ K+ P +A PH+ DN     E   
Sbjct: 203 PDEKTWEYMRGRTEVTPFSLASDEDAVFFETRNYDIAKINPKIAVPHNVDNVVDVTEVAG 262

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++V+IGSCT G+ EDF  AA+V L        V   +VPA++  +M V    +    
Sbjct: 263 KPVDQVFIGSCTNGRYEDFAEAAEV-LGDNVFSEDVRVIMVPASKAEYMKVLKAGL---- 317

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                + F EAG    A P CG C+GG    +  +   +V +ST+NRNF GR G  E  +
Sbjct: 318 ----IEKFVEAGALVEA-PCCGPCMGG---AFGLLAPGEVSLSTSNRNFRGRQGSTESFV 369

Query: 541 YLVSPYTAAAS 573
           YL SP TAAAS
Sbjct: 370 YLSSPATAAAS 380

[145][TOP]
>UniRef100_C8SB74 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SB74_FERPL
          Length = 419

 Score =  116 bits (291), Expect = 1e-24
 Identities = 81/195 (41%), Positives = 107/195 (54%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYES---VYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE 171
           PD +T  YL+    V YE    +YSD+ A +  E   DV+ LEP VA PHS DN     E
Sbjct: 229 PDKVTEDYLKS-IGVDYEIPEWLYSDEDA-YWKEVSLDVSNLEPQVACPHSVDNVKPVSE 286

Query: 172 CKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK-VPTFLVPATQKVWMDVYSLPV 348
            + VKI++V+IGSCT G+ ED   AA++    G K  K V   ++PA++  +        
Sbjct: 287 VEGVKIDQVFIGSCTNGRYEDLKVAAEIL--KGEKVAKGVRLIVIPASRSHYKRALK--- 341

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF EAG      PSCG C+GG   ++  +   +V +ST+NRNF GR G  
Sbjct: 342 -----EGLIDIFVEAGA-IVEFPSCGPCMGG---SFGLIASKEVSLSTSNRNFIGRQGSP 392

Query: 529 EGEIYLVSPYTAAAS 573
           EGEIYL SP TAAAS
Sbjct: 393 EGEIYLCSPATAAAS 407

[146][TOP]
>UniRef100_C7P908 3-isopropylmalate dehydratase n=1 Tax=Methanocaldococcus fervens
           AG86 RepID=C7P908_METFA
          Length = 420

 Score =  116 bits (291), Expect = 1e-24
 Identities = 73/199 (36%), Positives = 101/199 (50%), Gaps = 9/199 (4%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV---------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNR 156
           D ITY YL+ +  +  E +          +  +A +  E   D+T +E  VA PH PDN 
Sbjct: 224 DEITYNYLKNERGLSDEKIAELKKERITVNKDEANYYREIEIDITDMEEQVAVPHHPDNV 283

Query: 157 ALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVY 336
               E +  +IN+V+IGSCT G+  D   AAK +L  G     V   ++PA++KV++   
Sbjct: 284 KPVSEVEGTEINQVFIGSCTNGRLSDLREAAK-YLKGGKVHKDVKLIVIPASKKVFLQAL 342

Query: 337 SLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGR 516
                    +   + F +AG     +P CG CLG  +   A   E +VC+STTNRNF GR
Sbjct: 343 R--------EGLIETFIKAGA-MICTPGCGPCLGAHQGVLA---EGEVCLSTTNRNFRGR 390

Query: 517 MGHREGEIYLVSPYTAAAS 573
           MGH    IYL SP  AA S
Sbjct: 391 MGHINSYIYLASPKVAAIS 409

[147][TOP]
>UniRef100_A1RVH3 3-isopropylmalate dehydratase large subunit n=1 Tax=Pyrobaculum
           islandicum DSM 4184 RepID=LEUC_PYRIL
          Length = 414

 Score =  116 bits (291), Expect = 1e-24
 Identities = 70/191 (36%), Positives = 105/191 (54%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD +T  YL+ +  V Y+     Q  R++ +Y  +++KLEPLVA P+S DN    RE + 
Sbjct: 226 PDVVTVDYLQRERGVSYKPP-DLQPGRYVDKYVVELSKLEPLVAAPYSVDNVKAVREVEG 284

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V++++V+IGSCT G+  DF  AA++       +VK     +PA+  ++     L      
Sbjct: 285 VEVDQVFIGSCTNGRLSDFEIAARILRRG---RVKSRCIAIPASYTIFRKALELGY---- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                 I  +AGC      +CG CLGG    +      +V VST+NRNF GRMGH + ++
Sbjct: 338 ----IDILTKAGC-VVTYGTCGPCLGG---HFGVAGPGEVVVSTSNRNFKGRMGHPDSKV 389

Query: 541 YLVSPYTAAAS 573
           YL +P TAAA+
Sbjct: 390 YLANPATAAAA 400

[148][TOP]
>UniRef100_A0RMG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           fetus subsp. fetus 82-40 RepID=LEUC_CAMFF
          Length = 421

 Score =  116 bits (291), Expect = 1e-24
 Identities = 82/196 (41%), Positives = 109/196 (55%), Gaps = 6/196 (3%)
 Frame = +1

Query: 4   DSITYKYLEGKT--SVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC- 174
           D IT ++LE K   S P +  YSD+ A +    R DV+KL+P++A P  P N     E  
Sbjct: 230 DDITKEFLESKNLRSKP-KFHYSDEGANYEQVLRIDVSKLDPVIAYPFLPSNGKSINEAL 288

Query: 175 -KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLP 345
             D+KI++V+IGSCT G+  D   AA++     GK+V   T L+  PATQK+     +L 
Sbjct: 289 KDDLKIDQVFIGSCTNGRLSDLRIAARILK---GKRVAKHTRLIITPATQKI-----ALA 340

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
               G      IF EAG    ++P+CGACLGG       +   + CVSTTNRNF GRMG 
Sbjct: 341 AQKEG---LMDIFVEAGA-VVSNPTCGACLGGYMGI---LGAGERCVSTTNRNFVGRMGD 393

Query: 526 REGEIYLVSPYTAAAS 573
           R  E+YL +   AAAS
Sbjct: 394 RTSEVYLANSAVAAAS 409

[149][TOP]
>UniRef100_Q9WZ24 3-isopropylmalate dehydratase large subunit 2 n=2 Tax=Thermotoga
           RepID=LEUC2_THEMA
          Length = 417

 Score =  116 bits (291), Expect = 1e-24
 Identities = 73/194 (37%), Positives = 105/194 (54%), Gaps = 4/194 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D IT  Y E +  +  E +Y D+ A+++ E   D+++LEP VA P  P N     E +  
Sbjct: 228 DEITIAY-ERERGIEVEEMYPDEDAKYVREVEMDLSELEPQVAYPFLPSNAKDVSEAEKE 286

Query: 181 -VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVP 351
            +KI++  IGSCT G+ ED   AA++     G+ V   V   ++P +QKV+         
Sbjct: 287 RIKIDQAVIGSCTNGRIEDLRLAAQILK---GRTVSPDVRCIIIPGSQKVYKQALK---- 339

Query: 352 GSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
               +    IF +AGC   ++P+CG CLGG     A   E +V +STTNRNF GRMGH  
Sbjct: 340 ----EGLIDIFIDAGCAV-STPTCGPCLGGHMGVLA---EGEVAISTTNRNFVGRMGHPN 391

Query: 532 GEIYLVSPYTAAAS 573
            +++L SP  AAAS
Sbjct: 392 SKVFLASPAVAAAS 405

[150][TOP]
>UniRef100_O28084 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Archaeoglobus
           fulgidus RepID=LEUC2_ARCFU
          Length = 416

 Score =  116 bits (291), Expect = 1e-24
 Identities = 69/177 (38%), Positives = 102/177 (57%), Gaps = 2/177 (1%)
 Frame = +1

Query: 49  YESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKT 228
           +  V +D+ A +  E   DV+ L P+V+KPH+ DN A   E +  ++N+VYIG+CT G+ 
Sbjct: 242 FREVKADEDAEYEKEIYMDVSSLVPVVSKPHNVDNVAEISEVEGTEVNQVYIGTCTNGRL 301

Query: 229 EDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCD 402
            D   AA++     G+KVK  V   +VPA+++V++            K   ++F EAG  
Sbjct: 302 SDLEVAARIL---KGRKVKEGVRLIVVPASRRVYLQALD--------KGLIRVFVEAG-G 349

Query: 403 TPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
              +P CG C+G  +   A   + +VC+ST NRNF GRMG+   EI+L SP TAAAS
Sbjct: 350 MVLNPGCGPCVGIHQGILA---DGEVCISTQNRNFKGRMGNPNAEIFLASPATAAAS 403

[151][TOP]
>UniRef100_Q9UZ07 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           abyssi RepID=LEUC1_PYRAB
          Length = 423

 Score =  116 bits (291), Expect = 1e-24
 Identities = 73/194 (37%), Positives = 106/194 (54%), Gaps = 3/194 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRA-LARECK 177
           PD  T  Y++ +    ++   SD+ A++     +DVT  EP+VA PH P+N   +++  K
Sbjct: 230 PDKKTLDYVKERAKRKFKVYKSDEDAKYYKVIEYDVTNWEPVVAFPHLPENTVPISKAAK 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK-VPTFLVPATQKVWMDVYSLPVP 351
            ++KI++V+IGSCT G+ ED   AA++    G K  K V   ++P +  V+         
Sbjct: 290 MNIKIDQVFIGSCTNGRIEDLRMAAEIL--EGQKVAKWVRLIVIPCSPTVYWKALK---- 343

Query: 352 GSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
               +   +IF EAG      P+CG CLGG     A     +  VSTTNRNF GRMGH +
Sbjct: 344 ----EGLIEIFLEAGA-VIGPPTCGPCLGGHMGVLA---SGERAVSTTNRNFVGRMGHPK 395

Query: 532 GEIYLVSPYTAAAS 573
            E+YL +PY AAAS
Sbjct: 396 SEVYLANPYVAAAS 409

[152][TOP]
>UniRef100_C7I822 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermotoga
           naphthophila RKU-10 RepID=C7I822_9THEM
          Length = 417

 Score =  116 bits (290), Expect = 1e-24
 Identities = 72/194 (37%), Positives = 105/194 (54%), Gaps = 4/194 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D IT  Y E +  +  E +Y D+ A+++ E   D+++LEP VA P  P N     E +  
Sbjct: 228 DEITIAY-ERERGIEVEEMYPDEDAKYVREVEMDLSELEPQVAYPFLPSNAKDVSEAEKE 286

Query: 181 -VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVP 351
            +KI++  IGSCT G+ ED   AA++     G+ V   V   ++P +QKV+         
Sbjct: 287 RIKIDQAVIGSCTNGRIEDLRLAAQILK---GRTVSPDVRCIIIPGSQKVYKQALK---- 339

Query: 352 GSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
               +    +F +AGC   ++P+CG CLGG     A   E +V +STTNRNF GRMGH  
Sbjct: 340 ----EGLIDVFIDAGCAV-STPTCGPCLGGHMGVLA---EGEVAISTTNRNFVGRMGHPN 391

Query: 532 GEIYLVSPYTAAAS 573
            +++L SP  AAAS
Sbjct: 392 SKVFLASPAVAAAS 405

[153][TOP]
>UniRef100_A8RZ58 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RZ58_9CLOT
          Length = 420

 Score =  116 bits (290), Expect = 1e-24
 Identities = 68/192 (35%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +  +Y++  +   +    +D+ A +   Y  D+++L+P V+ PH P N     +  +V
Sbjct: 231 DELAVEYMKEHSKREFTVYEADEDAEYDETYVIDLSELKPTVSFPHLPSNTRTIDQVGEV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           K+++  IGSCT G+ ED   AA+V     G+K+   V   ++PATQ +++          
Sbjct: 291 KVDQAVIGSCTNGRIEDMRIAAEVL---KGRKIAKGVRCIVIPATQSIYLQAMK------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +IF EAG    ++P+CG CLGG     A     + C+STTNRNF GRMGH + E
Sbjct: 342 --EGLLEIFIEAGA-VVSTPTCGPCLGGYMGILA---AGERCISTTNRNFVGRMGHVDSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[154][TOP]
>UniRef100_A6LPX4 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           beijerinckii NCIMB 8052 RepID=LEUC_CLOB8
          Length = 419

 Score =  116 bits (290), Expect = 1e-24
 Identities = 72/192 (37%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL+   S  ++   +D+ A +   +  D+++L P V+ PH PDN        DV
Sbjct: 231 DDKTEEYLKDHASREWKVYEADEDAEYDKVFEIDLSELRPTVSFPHLPDNTRTIDNTGDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+  D   A  +     GKKVK  +   ++P TQK+++      +   
Sbjct: 291 AIDQVVIGSCTNGRISDLRMARDIL---KGKKVKKGIRCIVIPGTQKIYLQAIKEGIVTD 347

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                     EAG    ++P+CG CLGG     A+    + CVSTTNRNF GRMGH E E
Sbjct: 348 --------LVEAGA-AFSTPTCGPCLGGHMGILAK---GERCVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[155][TOP]
>UniRef100_C0C2K0 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0C2K0_9CLOT
          Length = 417

 Score =  115 bits (289), Expect = 2e-24
 Identities = 75/192 (39%), Positives = 97/192 (50%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  YL+      YE   SD  A F   Y+F   +L P VA PH  D    A   +DV
Sbjct: 230 DDITEAYLDSIGVKDYEPYQSDADASFYRTYQFRAEELRPQVACPHEVDRVTEADNVRDV 289

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           KI + Y+GSCTGG+  D   AA       GKKV   V   + PA++ +W +        +
Sbjct: 290 KIQQAYLGSCTGGRLHDLKTAAAYL---KGKKVAPGVRLLISPASRSIWRE--------A 338

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
           G      I  EAG     +P+CG C+G      A     + C+S++NRNF GRMG +EG+
Sbjct: 339 GRLGYLDILAEAG-GVIMAPTCGVCVGLHSGLIA---AGETCISSSNRNFLGRMGSKEGQ 394

Query: 538 IYLVSPYTAAAS 573
           IYL SP T AAS
Sbjct: 395 IYLGSPLTVAAS 406

[156][TOP]
>UniRef100_A5KNQ3 Putative uncharacterized protein n=1 Tax=Ruminococcus torques ATCC
           27756 RepID=A5KNQ3_9FIRM
          Length = 451

 Score =  115 bits (289), Expect = 2e-24
 Identities = 76/193 (39%), Positives = 98/193 (50%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T +YL+     PY    +D+ A +      D++K+ P VA PH P N     E +  
Sbjct: 237 DEKTVEYLDAHCEKPYTVYEADEDAVYDDVVEIDLSKVRPTVAFPHLPGNAKTIDEIEAE 296

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPG 354
             VKI++V IGSCT G+ ED   AA + L        V   +VPATQK++          
Sbjct: 297 EQVKIDQVVIGSCTNGRMEDMRKAAAI-LKGHTVHPDVRVMVVPATQKIYKQCIK----- 350

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF +AGC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH + 
Sbjct: 351 ---EGLLDIFVDAGCAVN-TPSCGPCMGGHMGVMAAGEK---CVSTTNRNFVGRMGHVDS 403

Query: 535 EIYLVSPYTAAAS 573
            IYL SP  AAAS
Sbjct: 404 LIYLASPEVAAAS 416

[157][TOP]
>UniRef100_C4ETQ1 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermanaerovibrio acidaminovorans DSM 6589
           RepID=C4ETQ1_9BACT
          Length = 420

 Score =  115 bits (288), Expect = 2e-24
 Identities = 64/175 (36%), Positives = 101/175 (57%)
 Frame = +1

Query: 49  YESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKT 228
           +E++++DQ A +  E  + +++L P VAKPH+ DN A   + K  +I++ +IGSCT G+ 
Sbjct: 248 WEAIWADQGATYAKELSYCLSELVPGVAKPHTVDNYAPVDQVKGAQIHQAFIGSCTNGRI 307

Query: 229 EDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTP 408
           ED   AA +     G++V V T ++PA+ +V+             +   + F +AGC   
Sbjct: 308 EDLREAATIL---KGRQVAVRTIVIPASWRVYRQAME--------EGLLETFLDAGC-VI 355

Query: 409 ASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
           ++P CG C+G  +   A     + C+ST NRNF GRMG+++  IYL SP T AAS
Sbjct: 356 SNPGCGPCMGNHQGILA---PGETCISTANRNFKGRMGNKDSFIYLASPLTVAAS 407

[158][TOP]
>UniRef100_C0D3T2 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0D3T2_9CLOT
          Length = 446

 Score =  115 bits (288), Expect = 2e-24
 Identities = 71/192 (36%), Positives = 104/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T  YL+  +   ++   +D  A + + Y  D+++L+P V+ PH P N        DV
Sbjct: 257 DEQTVAYLKEHSKRDFKVYEADPDAEYDATYVIDLSELKPTVSFPHLPSNTRTIDNVGDV 316

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++  IGSCT G+ +D   AA++     G+KV   V   ++PATQ +++          
Sbjct: 317 KIDQSVIGSCTNGRIDDMRVAAEIL---KGRKVAKNVRCIVIPATQAIYLQAMR------ 367

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +IF EAG    ++P+CG CLGG     A     + C+STTNRNF GRMGH + E
Sbjct: 368 --EGLLEIFVEAGA-IVSTPTCGPCLGGYMGILA---AGERCISTTNRNFVGRMGHVDSE 421

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 422 VYLASPAVAAAS 433

[159][TOP]
>UniRef100_C5STD4 3-isopropylmalate dehydratase n=1 Tax=Sulfolobus solfataricus 98/2
           RepID=C5STD4_SULSO
          Length = 415

 Score =  115 bits (288), Expect = 2e-24
 Identities = 70/191 (36%), Positives = 99/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++       E V  D  A+++ EY   + K+EPLVA PHS DN  +  E + 
Sbjct: 228 PDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDKMEPLVAAPHSVDNVKVVNELEG 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++VYIGSCT G+  DF  AAK+     GKKVK     +PA+ +++ +          
Sbjct: 288 TPVDQVYIGSCTNGRLSDFEIAAKIM---KGKKVKSRCIAIPASYRMFKEALE------- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   Q   +AGC      +CG CLGG    +      +  VST++RNF GRMG  E +I
Sbjct: 338 -RGYIQTLVDAGCIVTYG-TCGPCLGG---HFGIAGPGENIVSTSSRNFKGRMGSNEAKI 392

Query: 541 YLVSPYTAAAS 573
           YL  P  AA S
Sbjct: 393 YLSGPAVAAIS 403

[160][TOP]
>UniRef100_C4CQ67 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CQ67_9CHLR
          Length = 424

 Score =  115 bits (287), Expect = 3e-24
 Identities = 71/190 (37%), Positives = 97/190 (51%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  YL G+T  P++   SD  A F    R D+  + PL+A PHSP N     E    
Sbjct: 230 DEVTAAYLAGRTDRPWQPERSDPDASFARRVRIDLDGVPPLIALPHSPGNVVPVAEAAGR 289

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI++VYIG+C  G   D   AA + LA       V   +VPA+QKV+ +  +        
Sbjct: 290 KIDQVYIGNCANGTMTDLRQAASI-LAGNRVHPDVRAIIVPASQKVYREALA-------- 340

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +     F  AG    ++P+CGAC GG     A     +  V+TTNRNF GRMG  + E+Y
Sbjct: 341 EGLIDQFVAAGA-IVSTPTCGACFGGHMGVLA---AGERAVATTNRNFKGRMGSADAEVY 396

Query: 544 LVSPYTAAAS 573
           L + Y AAA+
Sbjct: 397 LANAYVAAAA 406

[161][TOP]
>UniRef100_B1L3C3 Homoaconitate hydratase family protein n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L3C3_KORCO
          Length = 384

 Score =  115 bits (287), Expect = 3e-24
 Identities = 75/192 (39%), Positives = 104/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  YL G+        YSD  +    E   DV+ LEPLVA PHSP N   A E  D 
Sbjct: 197 DDVTLSYLNGRLRRAPRPEYSDDGSHS-DEISIDVSSLEPLVAIPHSPANVKPASEV-DA 254

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           +I++ +IGSCTGG+ +D   AA++     G++VK  V   ++PA+++++++     +   
Sbjct: 255 EIDQAFIGSCTGGRLKDLEVAARILR---GRRVKEGVRLIVIPASRRIYLEALRRGI--- 308

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                  I  E+G  T   PSCG CLG      A   E +V +ST+NRNF GRMGH E  
Sbjct: 309 -----IDILIESGA-TIGPPSCGPCLGAHLGVLA---EGEVAISTSNRNFRGRMGHPESR 359

Query: 538 IYLVSPYTAAAS 573
           +YL S  T AAS
Sbjct: 360 VYLASAATVAAS 371

[162][TOP]
>UniRef100_B5IER5 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IER5_9EURY
          Length = 418

 Score =  115 bits (287), Expect = 3e-24
 Identities = 69/192 (35%), Positives = 102/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T  YL+ +   PYE ++ D+ A +   Y +D + L P +A PH+ DN     + + +
Sbjct: 229 DEKTEAYLKTRARAPYEIMHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           ++N+V++G+CT G+ ED   AA++     GKKV   V   + PA+  VW +        +
Sbjct: 289 EVNQVFLGTCTNGRVEDLEIAARIL---KGKKVNKNVRMLVFPASWDVWRE--------A 337

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             K   +   EAG     +P CG CLG      A   + + C+ST NRNF GRMG+   E
Sbjct: 338 DEKGILRTLAEAGA-VIMNPGCGPCLGAHAGVLA---DGEKCLSTANRNFKGRMGNPNAE 393

Query: 538 IYLVSPYTAAAS 573
           IYL SP TAAA+
Sbjct: 394 IYLGSPATAAAT 405

[163][TOP]
>UniRef100_B0K0Y2 3-isopropylmalate dehydratase large subunit n=4
           Tax=Thermoanaerobacter RepID=LEUC_THEPX
          Length = 418

 Score =  115 bits (287), Expect = 3e-24
 Identities = 72/192 (37%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  Y++G+    Y+    D+ A +   Y  ++ ++ P VA PH P+N     E   V
Sbjct: 229 DEITEAYVKGRAKREYKVFERDEDAEYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKV 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   A K+     GKKV   V   + PATQ+++++         
Sbjct: 289 KIDQVVIGSCTNGRLSDMEIAYKIL---KGKKVHPDVRLLIFPATQEIYLECVK------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F +AG    ++P+CG CLGG     AR    +  ++TTNRNF GRMGH E E
Sbjct: 340 --RGYIEEFIKAGA-AVSTPTCGPCLGGHMGILAR---GERALATTNRNFVGRMGHPESE 393

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 394 VYLSSPAVAAAS 405

[164][TOP]
>UniRef100_Q97EE0 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           acetobutylicum RepID=LEUC_CLOAB
          Length = 422

 Score =  115 bits (287), Expect = 3e-24
 Identities = 68/192 (35%), Positives = 104/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y++G++    +   +D+ A +      D++ L+P VA PH P+N     +  +V
Sbjct: 233 DEKTIEYMKGRSDRELKKFDADEDAEYSRVIEIDLSTLKPTVAFPHLPENTKTIDQVGEV 292

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            +++V IGSCT G+ ED   AA +     GKK+K  +   + P TQ ++++         
Sbjct: 293 NVDQVVIGSCTNGRMEDLRIAASIL---KGKKIKKGIRLIVFPGTQNIYLEAME------ 343

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAG    ++P+CG CLGG     A   E +  +STTNRNF GRMGH + E
Sbjct: 344 --EGLVRTFIEAG-GIVSTPTCGPCLGGHMGILA---EGERAISTTNRNFVGRMGHPKSE 397

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 398 VYLASPAVAAAS 409

[165][TOP]
>UniRef100_A6TSE5 3-isopropylmalate dehydratase n=1 Tax=Alkaliphilus metalliredigens
           QYMF RepID=A6TSE5_ALKMQ
          Length = 425

 Score =  114 bits (286), Expect = 4e-24
 Identities = 72/193 (37%), Positives = 106/193 (54%), Gaps = 3/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD     Y++ +T   +E + +D    + + Y F+V  L+P VA PHS DN     + K+
Sbjct: 226 PDEKIIAYVKERTGKTFEILKTDDDYEYAASYTFNVEDLKPQVALPHSVDNGVDIDKIKE 285

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVPG 354
           VK+++V+IG+CTGG+ ED   AA++       K+   T   ++PA+++V           
Sbjct: 286 VKVDQVFIGTCTGGRLEDIEVAARII---KNNKIHRDTRLLVIPASKEVLEKAIE----- 337

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEP-QVCVSTTNRNFPGRMGHRE 531
              K       +AG  T  SP CG CLG    T+  +  P +VC +T++RNFPGRMG  E
Sbjct: 338 ---KGYMTTLIKAGA-TFTSPGCGPCLG----THQGLLAPGEVCATTSSRNFPGRMGSTE 389

Query: 532 GEIYLVSPYTAAA 570
            +IYLVSP TAAA
Sbjct: 390 ADIYLVSPATAAA 402

[166][TOP]
>UniRef100_Q1Q122 Similar to 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q122_9BACT
          Length = 437

 Score =  114 bits (286), Expect = 4e-24
 Identities = 70/193 (36%), Positives = 102/193 (52%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT  Y+ G+    Y + +SD  + +   Y F+  ++ P VA P  P+N     +   
Sbjct: 237 PDKITENYVAGRVKREYVAYHSDPDSHYSKVYEFNAEEIVPQVALPSLPENTKSVYDVCG 296

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           +KI++V IGSCT G+  D   AAK+     GKK    +   ++PATQ+++          
Sbjct: 297 IKIDQVVIGSCTNGRISDLRIAAKIL---KGKKAHPSLRLIIIPATQEIYKQALK----- 348

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +A     ++P+CG CLGG     A   E +  ++TTNRNF GRMGH + 
Sbjct: 349 ---EGLIEIFIDAEA-VVSTPTCGPCLGGHMGILA---EGERALTTTNRNFVGRMGHPKS 401

Query: 535 EIYLVSPYTAAAS 573
           EIYL SP  AAAS
Sbjct: 402 EIYLCSPAVAAAS 414

[167][TOP]
>UniRef100_C6PJB4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacter italicus Ab9 RepID=C6PJB4_9THEO
          Length = 418

 Score =  114 bits (286), Expect = 4e-24
 Identities = 72/192 (37%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  Y++G+    Y+    D+ A +   Y  ++ ++ P VA PH P+N     E   V
Sbjct: 229 DEITEAYVKGRAKREYKVFERDEDAEYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKV 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   A K+     GKKV   V   + PATQ+++++         
Sbjct: 289 KIDQVVIGSCTNGRLSDMEIAYKIL---KGKKVHPDVRLLIFPATQEIYLECVK------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F +AG    ++P+CG CLGG     AR    +  ++TTNRNF GRMGH E E
Sbjct: 340 --RGYIEEFIKAGA-AISTPTCGPCLGGHMGILAR---GERALATTNRNFVGRMGHPESE 393

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 394 VYLSSPAVAAAS 405

[168][TOP]
>UniRef100_C1I927 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium sp.
           7_2_43FAA RepID=C1I927_9CLOT
          Length = 424

 Score =  114 bits (286), Expect = 4e-24
 Identities = 71/192 (36%), Positives = 99/192 (51%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +YL       ++   +D+ A +   Y  D++KL P VA PH PDN     E  +V
Sbjct: 231 DDVTIRYLVDHAQREWKVYEADEDAEYDEVYEIDLSKLRPTVAFPHLPDNTRTIDEVGEV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            +++V IGSCT G+  D   A  +      KKVK  V   + P TQK+++          
Sbjct: 291 AVDQVVIGSCTNGRISDLRVARDIL---KNKKVKKGVRCIVFPGTQKIYLQALE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +   EAG    ++P+CG CLGG     A+    +  +STTNRNF GRMGH E E
Sbjct: 342 --EGIIKDLVEAGA-VVSTPTCGPCLGGHMGILAK---GERAISTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[169][TOP]
>UniRef100_A6UPF6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           vannielii SB RepID=A6UPF6_METVS
          Length = 424

 Score =  114 bits (286), Expect = 4e-24
 Identities = 66/195 (33%), Positives = 101/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLE-----GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T +Y++       T+ P++ +  D+ A +  ++  +V  LEP++A PH+ DN    
Sbjct: 229 PDRKTVEYVKTAMEKNNTARPFDIIIGDKNAEYEEKFEIEVNDLEPVMACPHNVDNVKTV 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED  AA  V    GG    +   + PA++ V +      
Sbjct: 289 REVSGTPIDQVFIGSCTNGRIEDLRAALNVIEKHGGISKDIRVIVTPASRSVMLKALD-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   Q F + GC    +PSC AC+G     Y  +   +V ++T+NRNF GR G 
Sbjct: 347 ------EGLIQKFYKYGC-VVTNPSCSACMGA---LYGLLGPKEVGIATSNRNFRGREGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E ++YL SP TAAA
Sbjct: 397 LESDVYLASPITAAA 411

[170][TOP]
>UniRef100_B5IBY4 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IBY4_9EURY
          Length = 409

 Score =  114 bits (286), Expect = 4e-24
 Identities = 66/175 (37%), Positives = 101/175 (57%)
 Frame = +1

Query: 49  YESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKT 228
           ++++ +D++A ++ E   DV  LEPL+A P +P N     E + ++I+  +IGSCT G+ 
Sbjct: 242 FKAIEADKEAEYVEEIHIDVNNLEPLMASPPNPCNVHPVSEYEGMEIDGAFIGSCTNGRY 301

Query: 229 EDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTP 408
           ED +AAAK+     GKK+KVP  + P T+++W+ +          +   +IF EAG    
Sbjct: 302 EDLVAAAKIL---KGKKLKVPLTITPTTREIWLRLMK--------EGIWEIFAEAGA-VL 349

Query: 409 ASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
            +P CG C  G           +V +STTNRN+PG+ G   G++YLVSP  AAAS
Sbjct: 350 TNPGCGGCAEGMPGLIG----DEVYLSTTNRNYPGKQG--PGKLYLVSPVIAAAS 398

[171][TOP]
>UniRef100_B1YD98 3-isopropylmalate dehydratase large subunit n=1 Tax=Thermoproteus
           neutrophilus V24Sta RepID=LEUC_THENV
          Length = 415

 Score =  114 bits (286), Expect = 4e-24
 Identities = 68/191 (35%), Positives = 104/191 (54%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD +T  YL+ +  V Y+   S +  R++  Y  ++ +LEPLVA P+S DN   ARE + 
Sbjct: 226 PDEVTADYLQRERGVSYKPP-SLEPGRYVDRYEVELQRLEPLVAAPYSVDNVKAAREVEG 284

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V++++V+IGSCT G+  DF  AA+V       + K     +PA+  V+     L      
Sbjct: 285 VEVDQVFIGSCTNGRLSDFEVAARVLKRG---RAKARCIAIPASYAVFRRAMELGY---- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                 +  +AGC      +CG CLGG    +      +V V+T+NRNF GR+GH + ++
Sbjct: 338 ----IDVLTKAGC-VVTYGTCGPCLGG---HFGVAGPGEVVVTTSNRNFKGRVGHPDSKV 389

Query: 541 YLVSPYTAAAS 573
           YL +P TAAA+
Sbjct: 390 YLANPATAAAA 400

[172][TOP]
>UniRef100_A4WMI6 3-isopropylmalate dehydratase large subunit n=1 Tax=Pyrobaculum
           arsenaticum DSM 13514 RepID=LEUC_PYRAR
          Length = 415

 Score =  114 bits (286), Expect = 4e-24
 Identities = 68/191 (35%), Positives = 104/191 (54%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD++T +YL+    V Y    S +   +  +Y  ++ +LEPLVA PHS DN    RE + 
Sbjct: 226 PDAVTAEYLKTARGVDYTPP-SLEPGNYADKYTVELGRLEPLVAAPHSVDNVKTVREVEG 284

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V++++V+IGSCT G+  D   AA++     G++VK     +PA+ +V+     L      
Sbjct: 285 VEVDQVFIGSCTNGRLRDIATAARIL---KGRRVKTRCIAIPASYEVFKTAMKLGY---- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                 +  EAGC      +CG CLGG    +      +V ++T+NRNF GR+GH E +I
Sbjct: 338 ----IDVLTEAGC-VVTYGTCGPCLGG---HFGVAGPGEVHLTTSNRNFKGRVGHPEAKI 389

Query: 541 YLVSPYTAAAS 573
           YL +P  AAA+
Sbjct: 390 YLANPAVAAAT 400

[173][TOP]
>UniRef100_B1C4Q4 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C4Q4_9FIRM
          Length = 424

 Score =  114 bits (285), Expect = 5e-24
 Identities = 78/195 (40%), Positives = 104/195 (53%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T  Y+E  +   Y+   +D+ A +      D++K+ P VA PH P N     E + +
Sbjct: 230 DDQTIAYMEEHSKKDYKVYTADEDAEYERVIEIDLSKVRPTVAFPHLPGNGHTIDEIEAM 289

Query: 184 K---INRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPV 348
           +   I++V IGSCT G+  D   AA +     GKKV   V   +VPATQK+++      V
Sbjct: 290 EPIYIDQVVIGSCTNGRISDLRKAAAILK---GKKVARNVRVMVVPATQKIFLQCI---V 343

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
            G      ++IF EAGC    +PSCG C+GG     A+  +   CVSTTNRNF GRMG  
Sbjct: 344 EG-----LAEIFVEAGCAFN-TPSCGPCMGGHMGVMAKGEK---CVSTTNRNFVGRMGDT 394

Query: 529 EGEIYLVSPYTAAAS 573
           E  IYL SP  AAAS
Sbjct: 395 EALIYLASPEVAAAS 409

[174][TOP]
>UniRef100_B5IEF0 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IEF0_9EURY
          Length = 418

 Score =  114 bits (285), Expect = 5e-24
 Identities = 66/190 (34%), Positives = 100/190 (52%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T  YL+ +   PYE ++ D+ A +   Y +D + L P +A PH+ DN     + + +
Sbjct: 229 DEKTEAYLKTRARAPYEIMHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           ++N+V++G+CT G+ ED   AA++   +   K  V   + PA+  VW +        +  
Sbjct: 289 EVNQVFLGTCTNGRVEDLEVAARILKGNKVNK-NVRMLVFPASWDVWRE--------ANE 339

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           K   +   EAG     +P CG CLG      A   + + C+ST NRNF GRMG+   EIY
Sbjct: 340 KGILRTLAEAGA-VIMNPGCGPCLGAHAGVLA---DGEKCLSTANRNFKGRMGNPNAEIY 395

Query: 544 LVSPYTAAAS 573
           L SP TAAA+
Sbjct: 396 LGSPATAAAT 405

[175][TOP]
>UniRef100_Q1AVC5 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Rubrobacter
           xylanophilus DSM 9941 RepID=LEUC2_RUBXD
          Length = 424

 Score =  114 bits (285), Expect = 5e-24
 Identities = 68/190 (35%), Positives = 99/190 (52%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T +YL+ +    +    SD  A ++ + + D+  LEPLVA PHSP N     E +  
Sbjct: 230 DEVTARYLDRRADREWHPERSDPDASYVRKVKIDLNSLEPLVALPHSPGNVVAVSEARGT 289

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI++VYIG+C+ G   D    A++ L        V   +VPA+QKV+    S        
Sbjct: 290 KIDQVYIGNCSNGTITDLRQTAEI-LRGNRVHPDVRAIIVPASQKVYRQAIS-------- 340

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +    +F EAG    ++P+CGAC GG     A   E +  ++TTNRNF GRMG    E+ 
Sbjct: 341 EGLIDVFVEAGA-VVSTPTCGACFGGHMGVLA---EGERAITTTNRNFKGRMGSPLAEVC 396

Query: 544 LVSPYTAAAS 573
           L + Y AAA+
Sbjct: 397 LANAYVAAAA 406

[176][TOP]
>UniRef100_Q0QLE2 2,3-dimethylmalate dehydratase large subunit n=1 Tax=Eubacterium
           barkeri RepID=Q0QLE2_EUBBA
          Length = 420

 Score =  114 bits (284), Expect = 7e-24
 Identities = 76/193 (39%), Positives = 104/193 (53%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D  T  Y+E   S  Y+   +D  A +   +  D+++L+  VA PH P+N       ++ 
Sbjct: 231 DDQTISYMEEHGSGDYKVYAADADAVYEKTFDIDLSQLKSTVAFPHLPENTKTVDAIEEP 290

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           V I++V IGSCT G+ ED   AA +     GK VK  V   ++PAT K+++D        
Sbjct: 291 VTIDQVVIGSCTNGRFEDLKRAADILR---GKHVKKGVRMLVIPATHKIYLDAMEAGY-- 345

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
                  + F EAG  T ++P+CG CLGG     A   E + CVSTTNRNF GRMGH + 
Sbjct: 346 ------LREFIEAGA-TISTPTCGPCLGGYMGILA---EGERCVSTTNRNFVGRMGHVDS 395

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 396 EVYLASPEVAAAS 408

[177][TOP]
>UniRef100_B1C9W1 Putative uncharacterized protein n=1 Tax=Anaerofustis
           stercorihominis DSM 17244 RepID=B1C9W1_9FIRM
          Length = 424

 Score =  114 bits (284), Expect = 7e-24
 Identities = 73/196 (37%), Positives = 105/196 (53%), Gaps = 6/196 (3%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y +  ++  +E   +D+ A++      D++KL P V+ PH P+N     E   V
Sbjct: 231 DDKTIEYAKEHSTKTFEVFEADEDAQYDEVIEIDLSKLRPTVSFPHLPENTKTVDEAGKV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL----P 345
            I++  IGSCT G+ ED   AA +     GK+V  KV T ++PATQK+++D   L     
Sbjct: 291 YIDQAVIGSCTNGRLEDIKMAADIL---RGKQVDKKVRTIVIPATQKIYLDSIKLGYVED 347

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
           +  +G      IF        ++P+CG CLGG     A     +  +STTNRNF GRMGH
Sbjct: 348 IVNAGA-----IF--------STPTCGPCLGGHMGILA---AGEKAISTTNRNFVGRMGH 391

Query: 526 REGEIYLVSPYTAAAS 573
            + E+YL SP  AAAS
Sbjct: 392 VDSEVYLSSPAVAAAS 407

[178][TOP]
>UniRef100_A6BFK8 Putative uncharacterized protein n=1 Tax=Dorea longicatena DSM
           13814 RepID=A6BFK8_9FIRM
          Length = 424

 Score =  114 bits (284), Expect = 7e-24
 Identities = 75/193 (38%), Positives = 100/193 (51%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T +YL+  T   Y+   +D  A + S    D++++ P VA PH P N     E +  
Sbjct: 230 DEKTEEYLKEHTKKEYKVYEADGDAEYESVVEIDLSEVRPTVAFPHLPGNAKTIDEIEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPG 354
             +KI++V IGSCT G+ ED   AA + L        V   +VPATQK++          
Sbjct: 290 EPIKIDQVVIGSCTNGRMEDMRKAAAI-LQGHTVHPDVRVMVVPATQKIYKQCIR----- 343

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF +AGC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH + 
Sbjct: 344 ---EGLLEIFVDAGCAVN-TPSCGPCMGGHMGVMAAGEK---CVSTTNRNFVGRMGHVDS 396

Query: 535 EIYLVSPYTAAAS 573
            IYL SP  AAAS
Sbjct: 397 LIYLASPEVAAAS 409

[179][TOP]
>UniRef100_Q4JC09 3-isopropylmalate dehydratase large subunit n=1 Tax=Sulfolobus
           acidocaldarius RepID=LEUC_SULAC
          Length = 414

 Score =  114 bits (284), Expect = 7e-24
 Identities = 66/191 (34%), Positives = 100/191 (52%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T+ Y++       + V  D  A+++ EY  D++KL+PLVA PHS DN     E + 
Sbjct: 227 PDQETFNYIKTARGYEPQMVTPDSDAKYVDEYNIDLSKLDPLVAAPHSVDNVKSVNEVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++V+IGSCT G+  D   AAK+     GKKVK  T ++PA+ +++     L      
Sbjct: 287 TPVDQVFIGSCTNGRISDLEMAAKIL---KGKKVKTRTIVIPASYQLFKKALELGY---- 339

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                Q   +AG       +CG CLGG    +      +  +ST++RNF GRMG  + ++
Sbjct: 340 ----VQTLADAGAIITYG-TCGPCLGG---HFGIAGPGETIISTSSRNFKGRMGSPDAKV 391

Query: 541 YLVSPYTAAAS 573
           YL  P  AAA+
Sbjct: 392 YLSGPAVAAAT 402

[180][TOP]
>UniRef100_UPI0001979722 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI0001979722
          Length = 420

 Score =  113 bits (283), Expect = 9e-24
 Identities = 66/190 (34%), Positives = 101/190 (53%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT +Y +G+TS  +    +D+ A +   +  ++  ++  VA PH P+N     +  ++
Sbjct: 231 DDITIEYAKGRTSKEFRIYKADEDAEYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI++V IGSCT G+  D   AA +       K      ++PATQ ++++  +        
Sbjct: 291 KIDQVVIGSCTNGRLSDMEVAANILKDKTIAK-NTRCIIIPATQNIYLECIN-------- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +   + F +AG    ++P+CG CLGG     A   +   CVSTTNRNF GRMGH   E+Y
Sbjct: 342 RGYLETFIKAGA-VVSTPTCGPCLGGHMGILAANEK---CVSTTNRNFVGRMGHTTSEVY 397

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 398 LSSPEVAAAS 407

[181][TOP]
>UniRef100_B9KB94 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Thermotoga
           neapolitana DSM 4359 RepID=B9KB94_THENN
          Length = 417

 Score =  113 bits (283), Expect = 9e-24
 Identities = 71/192 (36%), Positives = 102/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD- 180
           D  T  Y E +  +  E +Y D+ A ++ E   ++++LEP VA P  P N     E +  
Sbjct: 228 DETTIAY-EKERGIEVEEMYPDEDAEYVKEVEMNLSELEPQVAYPFLPSNTKDISESEKE 286

Query: 181 -VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGS 357
            +KI++V IGSCT G+ ED   AA++ L        V   ++P +QKV+           
Sbjct: 287 RIKIDQVVIGSCTNGRIEDLRLAAQI-LKGRTVSPNVRCIIIPGSQKVYKQALK------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AGC   ++P+CG CLGG     A   E ++ VSTTNRNF GRMGH   +
Sbjct: 340 --EGLIDIFLDAGCAV-STPTCGPCLGGHMGVLA---EGEIAVSTTNRNFVGRMGHPNSK 393

Query: 538 IYLVSPYTAAAS 573
           ++L SP  AAAS
Sbjct: 394 VFLASPAVAAAS 405

[182][TOP]
>UniRef100_C3XG48 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XG48_9HELI
          Length = 420

 Score =  113 bits (283), Expect = 9e-24
 Identities = 66/190 (34%), Positives = 101/190 (53%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT +Y +G+TS  +    +D+ A +   +  ++  ++  VA PH P+N     +  ++
Sbjct: 231 DDITIEYAKGRTSKEFRIYKADEDAEYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI++V IGSCT G+  D   AA +       K      ++PATQ ++++  +        
Sbjct: 291 KIDQVVIGSCTNGRLSDMEVAANILKDKTIAK-NTRCIIIPATQNIYLECIN-------- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +   + F +AG    ++P+CG CLGG     A   +   CVSTTNRNF GRMGH   E+Y
Sbjct: 342 RGYLETFIKAGA-VVSTPTCGPCLGGHMGILAANEK---CVSTTNRNFVGRMGHTTSEVY 397

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 398 LSSPEVAAAS 407

[183][TOP]
>UniRef100_A1HLS2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HLS2_9FIRM
          Length = 420

 Score =  113 bits (283), Expect = 9e-24
 Identities = 70/192 (36%), Positives = 102/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL  +    YE+V  D  A ++     ++  LEP+VA PH P+N   A + +D+
Sbjct: 230 DDATIRYLSTRVERDYEAVSPDADASYVRTVVINLDDLEPVVALPHLPENVRPAAQVRDI 289

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+ ED   AA +     GK V  +V   ++P +Q V+++         
Sbjct: 290 AIDQVVIGSCTNGRLEDLAQAAAIL---EGKTVHPRVRAIVIPGSQAVYLEAMQ------ 340

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F  AG    ++P+CG CLGG     A     +  V+TTNRNF GRMGH + E
Sbjct: 341 --RGYIETFIRAGA-VVSTPTCGPCLGGYMGILA---AGERAVATTNRNFRGRMGHVDSE 394

Query: 538 IYLVSPYTAAAS 573
           +YL  P  AAAS
Sbjct: 395 VYLAGPAVAAAS 406

[184][TOP]
>UniRef100_C4KKU6 3-isopropylmalate dehydratase n=1 Tax=Sulfolobus islandicus M.16.4
           RepID=C4KKU6_SULIK
          Length = 415

 Score =  113 bits (283), Expect = 9e-24
 Identities = 68/191 (35%), Positives = 99/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++       E V  D  A+++ EY   + ++EPLVA PHS DN  +  E + 
Sbjct: 228 PDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDEMEPLVAAPHSVDNVKVVNELEG 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++VYIGSCT G+  DF  AAK+     GKKVK     +PA+ +++ +          
Sbjct: 288 TPVDQVYIGSCTNGRLSDFEIAAKIM---KGKKVKSRCIAIPASYRMFKEALE------- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   Q   +AGC      +CG CLGG    +      +  VST++RNF GRMG  E ++
Sbjct: 338 -RGYIQTLVDAGCIVTYG-TCGPCLGG---HFGIAGPGENIVSTSSRNFKGRMGSNEAKV 392

Query: 541 YLVSPYTAAAS 573
           YL  P  AA S
Sbjct: 393 YLSGPAVAAIS 403

[185][TOP]
>UniRef100_B5I9M1 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5I9M1_9EURY
          Length = 409

 Score =  113 bits (283), Expect = 9e-24
 Identities = 66/175 (37%), Positives = 100/175 (57%)
 Frame = +1

Query: 49  YESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKT 228
           ++ + +D++A ++ E   DV  LEPL+A P +P N     E + ++I+  +IGSCT G+ 
Sbjct: 242 FKVIKADKEAEYVEEIHIDVNNLEPLMASPPNPCNVHPVSEYEGMEIDGAFIGSCTNGRY 301

Query: 229 EDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTP 408
           ED +AAAK+     GKK+KVP  + P T+++W+ +          +   +IF EAG    
Sbjct: 302 EDLVAAAKIL---KGKKLKVPLTITPTTREIWLRLMK--------EGIWEIFAEAGA-VL 349

Query: 409 ASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
            +P CG C  G           +V +STTNRN+PG+ G   G++YLVSP  AAAS
Sbjct: 350 TNPGCGGCAEGMPGLIG----DEVYLSTTNRNYPGKQG--PGKLYLVSPVIAAAS 398

[186][TOP]
>UniRef100_Q97VY2 3-isopropylmalate dehydratase large subunit n=3 Tax=Sulfolobus
           RepID=LEUC_SULSO
          Length = 416

 Score =  113 bits (283), Expect = 9e-24
 Identities = 68/191 (35%), Positives = 99/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++       E V  D  A+++ EY   + ++EPLVA PHS DN  +  E + 
Sbjct: 229 PDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDEMEPLVAAPHSVDNVKVVNELEG 288

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++VYIGSCT G+  DF  AAK+     GKKVK     +PA+ +++ +          
Sbjct: 289 TPVDQVYIGSCTNGRLSDFEIAAKIM---KGKKVKSRCIAIPASYRMFKEALE------- 338

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   Q   +AGC      +CG CLGG    +      +  VST++RNF GRMG  E ++
Sbjct: 339 -RGYIQTLVDAGCIVTYG-TCGPCLGG---HFGIAGPGENIVSTSSRNFKGRMGSNEAKV 393

Query: 541 YLVSPYTAAAS 573
           YL  P  AA S
Sbjct: 394 YLSGPAVAAIS 404

[187][TOP]
>UniRef100_B8FMM4 3-isopropylmalate dehydratase large subunit n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=LEUC_DESAA
          Length = 419

 Score =  113 bits (283), Expect = 9e-24
 Identities = 70/191 (36%), Positives = 99/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD+ T +Y +G+         SD  A++     +DVT LEP VA PH P+N     +  +
Sbjct: 230 PDAKTKEYADGRVIRKPVFYASDPDAKYAKVIEYDVTDLEPQVAFPHLPENTRPISQVGE 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V I++V IGSCT G+ ED  +AA++   +   K  V   ++PAT +++            
Sbjct: 290 VPIHQVIIGSCTNGRIEDMRSAARILTGNKADK-NVRLIIIPATPQIYRQAME------- 341

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +     F  AG    + P+CG CLGG     A     +  V+TTNRNF GRMGH E E+
Sbjct: 342 -EGLFDTFLSAGA-VISPPTCGPCLGGHMGILA---AGERAVATTNRNFVGRMGHVESEV 396

Query: 541 YLVSPYTAAAS 573
           YL +P  AAAS
Sbjct: 397 YLANPAVAAAS 407

[188][TOP]
>UniRef100_B2UYH6 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum E3 str. Alaska E43 RepID=LEUC_CLOBA
          Length = 419

 Score =  113 bits (283), Expect = 9e-24
 Identities = 71/192 (36%), Positives = 100/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL+  T   ++   +D+ A +      D++ L+P V+ PH PDN         V
Sbjct: 231 DDKTVEYLKEHTEKEWKIYEADEDAEYDEVIEIDLSTLKPTVSFPHLPDNTRTIDNANRV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+  D   A  +     GKKVK  +   ++P TQK+++          
Sbjct: 291 NIDQVVIGSCTNGRISDLRIARGIL---KGKKVKKGIRCIVIPGTQKIYLQALE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +   EAG    ++P+CG CLGG     A+    + CVSTTNRNF GRMGH E E
Sbjct: 342 --EGIIKDLIEAGA-VVSTPTCGPCLGGHMGILAK---GERCVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[189][TOP]
>UniRef100_A8MDY8 3-isopropylmalate dehydratase large subunit n=1 Tax=Caldivirga
           maquilingensis IC-167 RepID=LEUC_CALMQ
          Length = 415

 Score =  113 bits (283), Expect = 9e-24
 Identities = 69/191 (36%), Positives = 107/191 (56%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  YL     +  + +  D  A+++ EY  ++ KLEPLVA PHS DN     E + 
Sbjct: 227 PDEETVSYLSRSRGINVKPITPDPDAKYVDEYTIELNKLEPLVAAPHSVDNVKPVSEVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           ++++ V+IGSCT G+  D  AAA++ L +G  KVK    ++PA++    D+++  +    
Sbjct: 287 IEVDYVFIGSCTNGRLSDLEAAARI-LKNG--KVKARCIVIPASR----DLFTKALDAGY 339

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +T +    +AGC      +CG CLGG    +  +   +  VST +RNF GRMG  EG++
Sbjct: 340 VETLT----KAGC-VVTYGTCGPCLGG---HFGVIGPGETAVSTGSRNFKGRMGSPEGKV 391

Query: 541 YLVSPYTAAAS 573
           YL +  TAAA+
Sbjct: 392 YLANAATAAAT 402

[190][TOP]
>UniRef100_C0WAT0 3-isopropylmalate dehydratase n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WAT0_9FIRM
          Length = 418

 Score =  113 bits (282), Expect = 1e-23
 Identities = 73/190 (38%), Positives = 97/190 (51%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T  Y +G+    YE V +D  A +      D+T L P+VA PH P N        D+
Sbjct: 230 DEKTKAYEQGRVE-DYEIVTADSDAVYKRTVTIDLTALTPVVAFPHLPGNTKAIGTFGDI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
            I++V IGSCT G+ ED   AAK+ L        V   ++P +Q+V+ +           
Sbjct: 289 PIDQVVIGSCTNGRLEDLAIAAKI-LEGRTVHPDVRCIVIPGSQEVYKEAMK-------- 339

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           K     F +AGC   ++P+CG CLGG     A     + CVSTTNRNF GRMGH + E+Y
Sbjct: 340 KGYIDTFIDAGC-VVSTPTCGPCLGGYMGILA---AGERCVSTTNRNFRGRMGHVDSEVY 395

Query: 544 LVSPYTAAAS 573
           L  P  AAAS
Sbjct: 396 LAGPQVAAAS 405

[191][TOP]
>UniRef100_B0G7V2 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G7V2_9FIRM
          Length = 425

 Score =  113 bits (282), Expect = 1e-23
 Identities = 75/195 (38%), Positives = 98/195 (50%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T +YL   T   Y    +D+ A +      D+ ++ P VA PH P N     E +  
Sbjct: 230 DDKTIQYLNEHTKKEYTVYEADEDAEYEQVVEIDLAEVRPTVAFPHLPGNAKTIDEIEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPV 348
             +KI++V IGSCT G+ ED   AA +     G KV   V   ++PATQK++        
Sbjct: 290 EPIKIDQVVIGSCTNGRMEDMRKAAAILK---GHKVHEDVRVMVIPATQKIYKQCIH--- 343

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF +AGC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH 
Sbjct: 344 -----EGLMDIFVDAGCAVN-TPSCGPCMGGHMGVMAAGEK---CVSTTNRNFVGRMGHV 394

Query: 529 EGEIYLVSPYTAAAS 573
           +  IYL SP  AAAS
Sbjct: 395 DSLIYLASPEVAAAS 409

[192][TOP]
>UniRef100_Q2NE97 LeuC1 n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NE97_METST
          Length = 418

 Score =  113 bits (282), Expect = 1e-23
 Identities = 72/192 (37%), Positives = 105/192 (54%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT +YL+ +T+  Y    +D+ A  L     DV+ LEP VA P+  DN   A E +DV
Sbjct: 230 DKITDEYLKNRTTKQYTKFTTDKDAASLEVMDIDVSDLEPQVACPNYVDNVKPASEVEDV 289

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           +I++V+IGSCT G+ +D   AA+V     G K+   V T ++PA++ ++           
Sbjct: 290 EIDQVFIGSCTNGRLKDLEQAARVL---KGNKINPGVRTLVIPASRTIYKQALD------ 340

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG     +P CG CLGG       + + +V +ST+NRNF GR G  EG+
Sbjct: 341 --EGLMDIFVDAGA-LICNPCCGPCLGGHVGV---IGDGEVSLSTSNRNFKGRQGSPEGK 394

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AA S
Sbjct: 395 VYLSSPIVAAES 406

[193][TOP]
>UniRef100_Q974R0 3-isopropylmalate dehydratase large subunit n=1 Tax=Sulfolobus
           tokodaii RepID=LEUC_SULTO
          Length = 415

 Score =  113 bits (282), Expect = 1e-23
 Identities = 68/191 (35%), Positives = 97/191 (50%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y++         V  D+ A+++ EY  D+ KLEPLVA PHS DN     E + 
Sbjct: 227 PDEETVNYIKTNRGYEPNIVRPDEGAKYVDEYTIDLGKLEPLVAAPHSVDNVKTVNEVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           + +++V+IGSCT G+  DF  AAK+     GK+VK     +PA+  ++     L      
Sbjct: 287 LDVDQVFIGSCTNGRISDFEIAAKIL---KGKRVKSRCIAIPASYDLFKKAMELGY---- 339

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +    AGC      +CG CLGG    +      +  VST++RNF GRMG  + ++
Sbjct: 340 ----IETLVNAGCIVTYG-TCGPCLGG---HFGVAGPGETIVSTSSRNFKGRMGSNDSKV 391

Query: 541 YLVSPYTAAAS 573
           YL  P  AAAS
Sbjct: 392 YLAGPAVAAAS 402

[194][TOP]
>UniRef100_A7IA28 3-isopropylmalate dehydratase large subunit n=1 Tax=Candidatus
           Methanoregula boonei 6A8 RepID=LEUC_METB6
          Length = 416

 Score =  113 bits (282), Expect = 1e-23
 Identities = 68/193 (35%), Positives = 108/193 (55%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD +T++Y++G+  +   ++ SD  A+F  +  ++V  LEP VA PH+ D      + + 
Sbjct: 227 PDKVTWEYMKGRRKITPFALASDDDAKFAEKRTYNVADLEPQVAVPHNVDQGIPVGKVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
             I++V+IGSCT G+ ED + AA+V    G KK   KV   ++PA++  ++      +  
Sbjct: 287 THIDQVFIGSCTNGRYEDLVEAAEVL---GKKKFDPKVRVLVIPASRDEYLKALEAGL-- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
                  + F  AG    A P CG C+GG   ++  +   +V ++T+NRNF GR G  EG
Sbjct: 342 ------VERFVRAGALVEA-PCCGPCMGG---SFGLIAAGEVSLATSNRNFRGRQGSTEG 391

Query: 535 EIYLVSPYTAAAS 573
           ++YL SP TAAAS
Sbjct: 392 KVYLCSPATAAAS 404

[195][TOP]
>UniRef100_Q3Z894 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z894_DEHE1
          Length = 416

 Score =  112 bits (281), Expect = 2e-23
 Identities = 68/192 (35%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y+  +    Y    +D  A +   Y FD++KLEP V+ PHSP N     +   +
Sbjct: 228 DEKTLEYVTPRAKRQYTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPISQIGKI 287

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
           K+++V IGSCT G+ ED   +AK+     G KV   + T ++P +Q+V++D         
Sbjct: 288 KVDQVIIGSCTNGRLEDLAISAKLL---EGNKVSPDLRTIVIPGSQQVYLDALKAGY--- 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                 + F  AG    ++P+CG CLGG     A     + C++TTNRNF GRMG  + E
Sbjct: 342 -----IETFINAGV-AVSTPTCGPCLGGHMGILA---AGERCLATTNRNFVGRMGSPKSE 392

Query: 538 IYLVSPYTAAAS 573
           +YL  P  AAA+
Sbjct: 393 VYLAGPAVAAAT 404

[196][TOP]
>UniRef100_C5UT24 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           botulinum E1 str. 'BoNT E Beluga' RepID=C5UT24_CLOBO
          Length = 419

 Score =  112 bits (281), Expect = 2e-23
 Identities = 71/192 (36%), Positives = 99/192 (51%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+ T KYL+  T   ++   +D+ A +      ++  L P V+ PH PDN         V
Sbjct: 231 DNKTVKYLKEHTVKEWKVYKADEDAEYDEVIEIELNTLRPTVSFPHLPDNTRTIDNANGV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+  D   A  +     GKKVK  +   ++P TQK+++          
Sbjct: 291 DIDQVVIGSCTNGRISDLRIARDIL---KGKKVKKGIRCIVIPGTQKIYLQALE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +   EAG    ++P+CG CLGG     A+    + CVSTTNRNF GRMGH E E
Sbjct: 342 --EGIIKDLIEAGA-VVSTPTCGPCLGGHMGILAK---GERCVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[197][TOP]
>UniRef100_B9D2G7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           rectus RM3267 RepID=B9D2G7_WOLRE
          Length = 424

 Score =  112 bits (281), Expect = 2e-23
 Identities = 75/195 (38%), Positives = 105/195 (53%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-- 174
           D  T ++L+GK       + YSD+ A +    + DV+KL+P++A P  P N    RE   
Sbjct: 233 DETTKEFLKGKNLRAEPKLHYSDEGANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVK 292

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPV 348
            D+ I++ +IGSCT G+  D   AA++     G+KV   T L+  PATQK+ +       
Sbjct: 293 DDIAIDQAFIGSCTNGRLSDLRIAAEILK---GRKVARKTRLIITPATQKIALQAQK--- 346

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF EAG    ++P+CGACLGG       +   + CVSTTNRNF GRMG R
Sbjct: 347 -----EGLMDIFAEAGA-VVSNPTCGACLGGYMGI---LGVGERCVSTTNRNFVGRMGDR 397

Query: 529 EGEIYLVSPYTAAAS 573
             E+YL +   AAAS
Sbjct: 398 TSEVYLANSAVAAAS 412

[198][TOP]
>UniRef100_C3MUB5 3-isopropylmalate dehydratase n=2 Tax=Sulfolobus islandicus
           RepID=C3MUB5_SULIM
          Length = 415

 Score =  112 bits (281), Expect = 2e-23
 Identities = 68/191 (35%), Positives = 98/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++       E V  D  A+++ EY   + ++EPLVA PHS DN  +  E + 
Sbjct: 228 PDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDEMEPLVAAPHSVDNVKVVNELEG 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++VYIGSCT G+  DF  AAK+     GKKVK     +PA+ +++ +          
Sbjct: 288 TPVDQVYIGSCTNGRLSDFEIAAKIM---KGKKVKSRCIAIPASYRMFKEALE------- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   Q   +AGC      +CG CLGG    +      +  VST++RNF GRMG  E  +
Sbjct: 338 -RGYIQTLVDAGCIITYG-TCGPCLGG---HFGIAGPGENIVSTSSRNFKGRMGSNEARV 392

Query: 541 YLVSPYTAAAS 573
           YL  P  AA S
Sbjct: 393 YLSGPAVAAIS 403

[199][TOP]
>UniRef100_A8ABG2 3-isopropylmalate dehydratase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8ABG2_IGNH4
          Length = 429

 Score =  112 bits (281), Expect = 2e-23
 Identities = 69/194 (35%), Positives = 107/194 (55%), Gaps = 4/194 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKT-SVPY-ESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 177
           D    +++EG+   VP  E  + D  A +  E+ +D++++EP+VAKP+SP N     E +
Sbjct: 229 DEEVMRFVEGRARGVPKPELTFPDPGAHYKDEFTYDLSEIEPMVAKPYSPANSVPVSEVE 288

Query: 178 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVP 351
            +++++V+IGSCT G+ ED   AA++     GKKV   T   ++ A++ V++        
Sbjct: 289 GIEVDQVFIGSCTNGRLEDVAVAARIL---KGKKVAPNTRCIVITASRNVYLQALK---- 341

Query: 352 GSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
               K    +  EAGC      +CG C+G     Y  +   +V + TTNRNF GR GHR 
Sbjct: 342 ----KGYVDVLTEAGC-LVTFGTCGPCVGA---HYGVLGPNEVGLFTTNRNFRGRSGHRT 393

Query: 532 GEIYLVSPYTAAAS 573
            ++YL SP TAAAS
Sbjct: 394 SKVYLASPATAAAS 407

[200][TOP]
>UniRef100_C6RH21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           showae RM3277 RepID=C6RH21_9PROT
          Length = 424

 Score =  112 bits (280), Expect = 2e-23
 Identities = 75/195 (38%), Positives = 104/195 (53%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-- 174
           D  T ++L+GK       + YSD+ A +      DV+KL+P++A P  P N    RE   
Sbjct: 233 DETTKEFLKGKNLRAEPKLHYSDEGANYEQILEIDVSKLDPVIAYPFLPSNGKSVREAVR 292

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPV 348
            D+ I++ +IGSCT G+  D   AA++     G+KV   T L+  PATQK+ +       
Sbjct: 293 DDIAIDQAFIGSCTNGRLSDLRIAAEILK---GRKVARKTRLIITPATQKIALQAQK--- 346

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF EAG    ++P+CGACLGG       +   + CVSTTNRNF GRMG R
Sbjct: 347 -----EGLMDIFAEAGA-VVSNPTCGACLGGYMGI---LGVGERCVSTTNRNFVGRMGDR 397

Query: 529 EGEIYLVSPYTAAAS 573
             E+YL +   AAAS
Sbjct: 398 TSEVYLANSAVAAAS 412

[201][TOP]
>UniRef100_C5F2A2 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           pullorum MIT 98-5489 RepID=C5F2A2_9HELI
          Length = 422

 Score =  112 bits (280), Expect = 2e-23
 Identities = 74/198 (37%), Positives = 111/198 (56%), Gaps = 7/198 (3%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSV---PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALAR 168
           PD IT ++L+ +  +   P E  YSD  A +    + D++KLEP++A P  P N +++++
Sbjct: 229 PDEITREFLKSRPFLRANPRE-FYSDADANYTQTIQIDISKLEPVIAYPFLPSNGKSISQ 287

Query: 169 ECKD-VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYS 339
             KD +KI++V+IGSCT G+  D   A+++     GKKV   V   + P TQ ++ + + 
Sbjct: 288 ALKDDLKIDQVFIGSCTNGRLSDLKIASEILK---GKKVHQDVRLIITPGTQNIYKEAHK 344

Query: 340 LPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRM 519
           L            I  EAG    ++P+CGACLGG       + + + CVSTTNRNF GRM
Sbjct: 345 LGY--------IDILLEAGA-LISNPTCGACLGGYMGI---LGDNERCVSTTNRNFVGRM 392

Query: 520 GHREGEIYLVSPYTAAAS 573
           G R  E+YL +   AA S
Sbjct: 393 GARNSEVYLANSAVAAIS 410

[202][TOP]
>UniRef100_C4V4K3 3-isopropylmalate dehydratase n=1 Tax=Selenomonas flueggei ATCC
           43531 RepID=C4V4K3_9FIRM
          Length = 420

 Score =  112 bits (280), Expect = 2e-23
 Identities = 71/193 (36%), Positives = 102/193 (52%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KD 180
           D +   Y+EG+ + P+  V +D  AR+      D++ L P+V+ PH P+N     +    
Sbjct: 230 DDVCRAYVEGRMTKPFAPVAADADARYAQTVEIDLSALRPVVSFPHLPENTKRVMDIGAP 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           + I++V IGSCT G+ ED   AA +     G KV  +V   ++P +  V+ +        
Sbjct: 290 IAIDQVVIGSCTNGRLEDMEIAASILK---GHKVHERVRCIVIPGSPYVYEE-------- 338

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
           S  +    IF EAG    ++P+CG CLGG     A       CVSTTNRNF GRMGH + 
Sbjct: 339 SMKRGYLAIFMEAGAAI-STPTCGPCLGGYMGILAAGER---CVSTTNRNFRGRMGHVDS 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL  P+ AAAS
Sbjct: 395 EVYLAGPHVAAAS 407

[203][TOP]
>UniRef100_C3MKR7 3-isopropylmalate dehydratase n=1 Tax=Sulfolobus islandicus
           L.S.2.15 RepID=C3MKR7_SULIL
          Length = 415

 Score =  112 bits (280), Expect = 2e-23
 Identities = 68/191 (35%), Positives = 98/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T +Y++       E V  D  A+++ EY   + ++EPLVA PHS DN  +  E   
Sbjct: 228 PDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDEMEPLVAAPHSVDNVKVVNELGG 287

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++VYIGSCT G+  DF  AAK+     GKKVK     +PA+ +++ +          
Sbjct: 288 TPVDQVYIGSCTNGRLSDFEIAAKIM---KGKKVKSRCIAIPASYRMFKEALE------- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
            +   Q   +AGC      +CG CLGG    +      +  VST++RNF GRMG  E ++
Sbjct: 338 -RGYIQTLVDAGCIVTYG-TCGPCLGG---HFGIAGPGENIVSTSSRNFKGRMGSNEAKV 392

Query: 541 YLVSPYTAAAS 573
           YL  P  AA S
Sbjct: 393 YLSGPAVAAIS 403

[204][TOP]
>UniRef100_Q2LWJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Syntrophus
           aciditrophicus SB RepID=LEUC_SYNAS
          Length = 420

 Score =  112 bits (280), Expect = 2e-23
 Identities = 72/193 (37%), Positives = 99/193 (51%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT  Y++ +   PY    SD  A +      DV ++EP VA PH P N     E   
Sbjct: 230 PDEITEAYVKPRAKRPYTFYASDPDAAYAQVIEIDVNRIEPQVAFPHLPSNTKGISEVGQ 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           V +++V IGSCT G+ ED  AAA V     G+K   +V   ++PATQ+++          
Sbjct: 290 VPLDQVVIGSCTNGRIEDLRAAAAVL---KGRKADPRVRLIVIPATQEIYRMAMK----- 341

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF +A     ++P+CG CLGG     A     +  ++TTNRNF GRMGH   
Sbjct: 342 ---EGLFDIFLDANA-AISTPTCGPCLGGHMGILA---AGERALATTNRNFVGRMGHPRS 394

Query: 535 EIYLVSPYTAAAS 573
           E+YL +P  AAAS
Sbjct: 395 EVYLSNPAVAAAS 407

[205][TOP]
>UniRef100_Q58409 Homoaconitase large subunit n=1 Tax=Methanocaldococcus jannaschii
           RepID=HACA_METJA
          Length = 420

 Score =  112 bits (280), Expect = 2e-23
 Identities = 71/199 (35%), Positives = 100/199 (50%), Gaps = 9/199 (4%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV---------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNR 156
           D ITY YL+ +  +  E +          +  +A +  E   D+T +E  VA PH PDN 
Sbjct: 224 DEITYDYLKKERGLSDEDIAKLKKERITVNRDEANYYKEIEIDITDMEEQVAVPHHPDNV 283

Query: 157 ALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVY 336
               + +  +IN+V+IGSCT G+  D   AAK +L        V   ++PA++KV++   
Sbjct: 284 KPISDVEGTEINQVFIGSCTNGRLSDLREAAK-YLKGREVHKDVKLIVIPASKKVFLQAL 342

Query: 337 SLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGR 516
                    +    IF +AG     +P CG CLG  +   A   E ++C+STTNRNF GR
Sbjct: 343 K--------EGIIDIFVKAGA-MICTPGCGPCLGAHQGVLA---EGEICLSTTNRNFKGR 390

Query: 517 MGHREGEIYLVSPYTAAAS 573
           MGH    IYL SP  AA S
Sbjct: 391 MGHINSYIYLASPKIAAIS 409

[206][TOP]
>UniRef100_A5FR41 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FR41_DEHSB
          Length = 416

 Score =  112 bits (279), Expect = 3e-23
 Identities = 66/190 (34%), Positives = 99/190 (52%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y+  +    Y    +D  A +   Y FD++KLEP V+ PHSP N     +   +
Sbjct: 228 DEKTLEYVTPRAKRQYTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPVSQIGKI 287

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           K+++V IGSCT G+ ED   +AK+ L        + T ++P +Q+V++D           
Sbjct: 288 KVDQVIIGSCTNGRLEDLAVSAKL-LKGNVVHPDLRTIVIPGSQQVYLDALKAGY----- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
               + F  AG    ++P+CG CLGG     A     + C++TTNRNF GRMG  + E+Y
Sbjct: 342 ---IETFINAGV-AVSTPTCGPCLGGHMGILA---AGERCLATTNRNFVGRMGSPKSEVY 394

Query: 544 LVSPYTAAAS 573
           L  P  AAA+
Sbjct: 395 LAGPAVAAAT 404

[207][TOP]
>UniRef100_C7MMM0 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Cryptobacterium curtum DSM 15641 RepID=C7MMM0_CRYCD
          Length = 423

 Score =  112 bits (279), Expect = 3e-23
 Identities = 72/192 (37%), Positives = 96/192 (50%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D+ T  YL+ +T  PY     D+ A +      D   + P VA PH P N     E +DV
Sbjct: 234 DTTTRAYLDARTERPYTVYNPDEGAVYARTITIDAADIVPTVAFPHLPSNTRPVAEARDV 293

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            I++  IGSCT G+ ED  AAA V     G+ V  +V   ++PATQ V+           
Sbjct: 294 AIDQAVIGSCTNGRIEDMRAAAHVL---NGRTVHPRVRCIVIPATQAVFKQCID------ 344

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +  + IF  A C   ++P+CG CLGG     A     +  ++TTNRNF GRMG    E
Sbjct: 345 --EGLTDIFVNAHC-VVSTPTCGPCLGGHMGVLA---PGERAIATTNRNFIGRMGDTTSE 398

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 399 VYLASPAVAAAS 410

[208][TOP]
>UniRef100_A1HRB9 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HRB9_9FIRM
          Length = 420

 Score =  112 bits (279), Expect = 3e-23
 Identities = 74/194 (38%), Positives = 100/194 (51%), Gaps = 3/194 (1%)
 Frame = +1

Query: 1   PDSITYKYLEGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 177
           PD+   +YL+ +  +  Y    SD  A F + YRFD ++LEP+VA PH  DN       K
Sbjct: 229 PDTKVVEYLKARGITEGYTLFASDSDAVFCATYRFDASELEPVVACPHEVDNVTELSNVK 288

Query: 178 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVP 351
              I++ YIGSCTGG+  D  AAA+V     G+KV   V   + PA+ ++W         
Sbjct: 289 GQVIHQAYIGSCTGGRYNDLAAAARVL---KGRKVANGVRLLVSPASHEIWRQ------- 338

Query: 352 GSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
            +       I  EAG    A P+CG C+G      A   + + C+S+TNRNF GRMG + 
Sbjct: 339 -AAADGILSILAEAGAIILA-PTCGVCVGLHSGLLA---DGEYCISSTNRNFIGRMGSKN 393

Query: 532 GEIYLVSPYTAAAS 573
             IYL SP   AAS
Sbjct: 394 AGIYLASPMAVAAS 407

[209][TOP]
>UniRef100_C5U763 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           infernus ME RepID=C5U763_9EURY
          Length = 424

 Score =  112 bits (279), Expect = 3e-23
 Identities = 69/195 (35%), Positives = 97/195 (49%), Gaps = 5/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALA 165
           PD  T  Y++       T   ++ +  D+ A F   Y  +  K+EP+ A PH+ DN    
Sbjct: 229 PDEKTINYVKEAMEKHGTLREFKPIKGDEDAEFSEVYEIEADKIEPVFACPHNVDNVKQC 288

Query: 166 RECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLP 345
           RE     I++V+IGSCT G+ ED   A  V    GG    V   + PA+++ ++      
Sbjct: 289 REVAGKPIDQVFIGSCTNGRLEDLRMAINVIEKHGGIAEDVRVIVTPASREEYLKALK-- 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +   + F + GC    +PSC AC+G     Y  +   +VCVST+NRNF GR G 
Sbjct: 347 ------EGIIEKFIKYGC-VVTNPSCSACMG---SLYGVLGPGEVCVSTSNRNFRGRQGS 396

Query: 526 REGEIYLVSPYTAAA 570
            E EIYL SP TAAA
Sbjct: 397 LEAEIYLASPITAAA 411

[210][TOP]
>UniRef100_B2TIQ9 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum B str. Eklund 17B RepID=LEUC_CLOBB
          Length = 419

 Score =  112 bits (279), Expect = 3e-23
 Identities = 70/192 (36%), Positives = 98/192 (51%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL+  T   +E   +D+ A +      ++  L P V+ PH PDN        D+
Sbjct: 231 DDKTVEYLKEHTKKEWEVYKADEDAEYDEVIEIELNTLRPTVSFPHLPDNTRTIDNVGDI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I++V IGSCT G+  D   A  +     GKKVK  +   ++P TQ +++          
Sbjct: 291 DIDQVVIGSCTNGRISDLRIARDIL---KGKKVKKGIRCIVIPGTQNIYLQALE------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   +   EAG    ++P+CG CLGG     A+    + CVSTTNRNF GRMGH E E
Sbjct: 342 --EGIIKDLIEAGV-VVSTPTCGPCLGGHMGILAK---GERCVSTTNRNFVGRMGHVESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[211][TOP]
>UniRef100_Q703X6 3-isopropylmalate dehydratase large subunit n=1 Tax=Thermoproteus
           tenax RepID=Q703X6_THETE
          Length = 415

 Score =  111 bits (278), Expect = 3e-23
 Identities = 68/191 (35%), Positives = 100/191 (52%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PDS TY YLE KT      V      +++ EY  ++ +LEPLVA PHS DN    RE + 
Sbjct: 228 PDSETYAYLE-KTRGAAPRVDFVPGGKYIDEYTVELDRLEPLVAAPHSVDNVKSVREVEG 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V++++V+IGSCT G+  D  AAA++       + K     +PA+  V+            
Sbjct: 287 VEVDQVFIGSCTNGRLSDIEAAARILKRG---RAKARCIAIPASYSVFRQALEAGY---- 339

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                 +  +AGC      +CG C+GG    +  +   +  VST+NRNF GRMG  + ++
Sbjct: 340 ----IDVLTKAGC-VVTYGTCGPCIGG---HFGVLGPGETAVSTSNRNFVGRMGANDSKV 391

Query: 541 YLVSPYTAAAS 573
           YL + YTAAA+
Sbjct: 392 YLANAYTAAAA 402

[212][TOP]
>UniRef100_B0KAH5 3-isopropylmalate dehydratase large subunit n=3
           Tax=Thermoanaerobacter RepID=LEUC_THEP3
          Length = 417

 Score =  111 bits (278), Expect = 3e-23
 Identities = 71/192 (36%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  Y++G+    Y+    D  A +   Y   + ++ P VA PH P+N     E   V
Sbjct: 229 DEITEAYVKGRAKREYKVFERDVDAEYSEVYEISLDEIRPQVAFPHLPENTRNIDEVGKV 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   A K+     GKKV   V   + PATQ+++++         
Sbjct: 289 KIDQVVIGSCTNGRISDMEIAYKIL---KGKKVHPDVRLLIFPATQEIYLECVK------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F +AG    ++P+CG CLGG     A+    +  ++TTNRNF GRMGH E E
Sbjct: 340 --RGYIEEFIKAGA-AVSTPTCGPCLGGHMGILAK---GERALATTNRNFVGRMGHPESE 393

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 394 VYLSSPAVAAAS 405

[213][TOP]
>UniRef100_A4YF03 3-isopropylmalate dehydratase large subunit n=1 Tax=Metallosphaera
           sedula DSM 5348 RepID=LEUC_METS5
          Length = 415

 Score =  111 bits (278), Expect = 3e-23
 Identities = 70/191 (36%), Positives = 99/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD  T  Y++       E V  D  A++L E+  ++ KLEPLVA P+S DN   ARE   
Sbjct: 227 PDVETKDYIKTMRGKEVELVTPDPGAKYLDEHTIELDKLEPLVAAPYSVDNVKTAREESK 286

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V +++VYIGSCT G+  DF  A+++     GKKVK     +P++  ++     +      
Sbjct: 287 VPVDQVYIGSCTNGRLSDFRIASEIL---KGKKVKTRCIAIPSSYTMFKQAMEMGY---- 339

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                +    AGC      +CG CLGG    +      +V VST++RNF GRMG  E ++
Sbjct: 340 ----IEDLVNAGC-VVTYGTCGPCLGG---HFGVAGPGEVIVSTSSRNFRGRMGSNEAKV 391

Query: 541 YLVSPYTAAAS 573
           YL  P  AAAS
Sbjct: 392 YLSGPSVAAAS 402

[214][TOP]
>UniRef100_UPI000196B289 hypothetical protein CATMIT_00953 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196B289
          Length = 425

 Score =  111 bits (277), Expect = 5e-23
 Identities = 75/195 (38%), Positives = 100/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D    +YL+      Y+   +D+ A +      D++ + P VA PH P N     E +  
Sbjct: 230 DEAAIEYLDKHAKRDYKIYEADKDAEYEEIVDVDLSAIRPTVAFPHLPGNAKTVDEIEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPV 348
             + I++V IGSCT G+ ED   AA +     GKKV   V   +VPATQK+++      +
Sbjct: 290 DKIYIDQVVIGSCTNGRMEDLRKAAAILK---GKKVADNVRVMVVPATQKIYLQCILEGI 346

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                    + F EAGC    +PSCG C+GG     A+  +   CVSTTNRNF GRMG  
Sbjct: 347 --------LETFVEAGCAVN-TPSCGPCMGGHMGVLAKGEK---CVSTTNRNFVGRMGDV 394

Query: 529 EGEIYLVSPYTAAAS 573
           E  IYL SP TAAAS
Sbjct: 395 ESLIYLASPETAAAS 409

[215][TOP]
>UniRef100_Q3ZXI5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. CBDB1 RepID=Q3ZXI5_DEHSC
          Length = 416

 Score =  111 bits (277), Expect = 5e-23
 Identities = 65/190 (34%), Positives = 99/190 (52%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y+  +    Y    +D  A +   Y FD++K+EP V+ PHSP N     +   +
Sbjct: 228 DEKTLEYVTPRAKRQYTVYDNDADASYAKTYNFDISKIEPQVSLPHSPANARPVSQIGKI 287

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           K+++V IGSCT G+ ED   +AK+ L        + T ++P +Q+V++D           
Sbjct: 288 KVDQVIIGSCTNGRLEDLAVSAKL-LKGNVVHPDLRTIVIPGSQQVYLDALKAGY----- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
               + F  AG    ++P+CG CLGG     A     + C++TTNRNF GRMG  + E+Y
Sbjct: 342 ---IETFINAGV-AVSTPTCGPCLGGHMGILA---AGERCLATTNRNFVGRMGSPKSEVY 394

Query: 544 LVSPYTAAAS 573
           L  P  AAA+
Sbjct: 395 LAGPAVAAAT 404

[216][TOP]
>UniRef100_A8CP51 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. VS RepID=A8CP51_9CHLR
          Length = 416

 Score =  111 bits (277), Expect = 5e-23
 Identities = 66/190 (34%), Positives = 99/190 (52%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +Y+  +    Y    +D  A +   Y FD++KLEP V+ PHSP N     +   +
Sbjct: 228 DEKTLEYVTPRAKRQYTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPISQIGKI 287

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           K+++V IGSCT G+ ED   +AK+ L        + T ++P +Q+V++D           
Sbjct: 288 KVDQVIIGSCTNGRLEDLAISAKL-LEVNKVNPDLRTIVIPGSQQVYLDALKAGY----- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
               + F  AG    ++P+CG CLGG     A     + C++TTNRNF GRMG  + E+Y
Sbjct: 342 ---IETFINAGV-AVSTPTCGPCLGGHMGILA---AGERCLATTNRNFVGRMGSPKSEVY 394

Query: 544 LVSPYTAAAS 573
           L  P  AAA+
Sbjct: 395 LAGPAVAAAT 404

[217][TOP]
>UniRef100_A7B6Z9 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC
           29149 RepID=A7B6Z9_RUMGN
          Length = 425

 Score =  111 bits (277), Expect = 5e-23
 Identities = 73/193 (37%), Positives = 97/193 (50%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T  YLE  +   Y+   +D+ A +      D++++ P VA PH P N     E +  
Sbjct: 230 DEQTKAYLEEHSKKEYQIFEADEDADYEQVVTIDLSEVRPTVAFPHLPGNAKTIDEIEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPG 354
             +KI++V IGSCT G+ ED   AA + L        V   ++PATQK++          
Sbjct: 290 EPIKIDQVVIGSCTNGRMEDMRKAAAI-LKGHTVHPDVRVMVIPATQKIYKQCIK----- 343

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF +AGC    +PSCG C+GG     A       CVSTTNRNF GRMGH + 
Sbjct: 344 ---EGLLDIFVDAGCAVN-TPSCGPCMGGHMGVMAAGER---CVSTTNRNFVGRMGHVDS 396

Query: 535 EIYLVSPYTAAAS 573
            IYL SP  AAAS
Sbjct: 397 LIYLASPEVAAAS 409

[218][TOP]
>UniRef100_Q8ZW41 3-isopropylmalate dehydratase large subunit n=1 Tax=Pyrobaculum
           aerophilum RepID=LEUC_PYRAE
          Length = 415

 Score =  111 bits (277), Expect = 5e-23
 Identities = 68/191 (35%), Positives = 103/191 (53%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD IT +YL+ +  V Y     +    +  +Y  ++ +LEPLVA P+S DN    RE + 
Sbjct: 226 PDVITAEYLKTERGVDYTPPRIEP-GNYADKYTVELPRLEPLVAAPYSVDNIKSVREVEG 284

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
           V++++V+IGSCT G+  D   AAK+     G++VK     +PA+ +V+     L      
Sbjct: 285 VEVDQVFIGSCTNGRLSDIAVAAKIL---KGRRVKSRCIAIPASYEVFRRAMKLGY---- 337

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                 +  EAGC      +CG CLGG    +      +V V+T+NRNF GR+GH + +I
Sbjct: 338 ----IDVLTEAGC-VVTYGTCGPCLGG---HFGVAGPGEVVVTTSNRNFRGRVGHPDAKI 389

Query: 541 YLVSPYTAAAS 573
           YL +P  AAA+
Sbjct: 390 YLANPAVAAAT 400

[219][TOP]
>UniRef100_A7VNU8 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753
           RepID=A7VNU8_9CLOT
          Length = 428

 Score =  110 bits (276), Expect = 6e-23
 Identities = 72/192 (37%), Positives = 97/192 (50%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  Y  G+         +D+ A +  EY  D++ L P VA PH P+N         V
Sbjct: 231 DDVTRAYCNGRFQGTPVEYAADEDAVYEKEYVIDLSALRPTVAFPHLPENTRTIDNVGQV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++V IGSCT G+  D   AA +     GKKV   V   + P TQ +++D         
Sbjct: 291 KIDQVVIGSCTNGRLSDLRIAANLL---KGKKVAKNVRCIVFPGTQTIYLDAMR------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F +AG    ++P+CG CLGG     A     +  VSTTNRNF GRMGH + E
Sbjct: 342 --EGLVEAFIQAGA-VVSTPTCGPCLGGHMGILA---AGERAVSTTNRNFVGRMGHVDSE 395

Query: 538 IYLVSPYTAAAS 573
           +YL SP  AAAS
Sbjct: 396 VYLASPAVAAAS 407

[220][TOP]
>UniRef100_A6Q5L6 3-isopropylmalate dehydratase large subunit n=1 Tax=Nitratiruptor
           sp. SB155-2 RepID=LEUC_NITSB
          Length = 421

 Score =  110 bits (276), Expect = 6e-23
 Identities = 75/195 (38%), Positives = 105/195 (53%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK 177
           D +T  +L  K       + YSD+ A +      DV  LEP++A PH P N R ++   K
Sbjct: 230 DEVTKAFLADKPLAREPKIHYSDEDAEYEQVIEIDVNNLEPVIAFPHLPSNGRPISEAAK 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPV 348
            D+K+++V+IGSCT G+  D   AA++     G+KV   T ++  PATQK+  +      
Sbjct: 290 MDLKVDQVFIGSCTNGRLSDIAIAAEILK---GRKVARHTRMIVTPATQKILKEAEK--- 343

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    I  +AG    ++P+CGACLGG     A   + + CVSTTNRNF GRMG R
Sbjct: 344 -----RGYIDILIDAGA-VVSNPTCGACLGGYMGILA---DNERCVSTTNRNFVGRMGAR 394

Query: 529 EGEIYLVSPYTAAAS 573
             EIYL +   AAAS
Sbjct: 395 TSEIYLANSAVAAAS 409

[221][TOP]
>UniRef100_C5CJ10 Homoaconitate hydratase family protein n=1 Tax=Kosmotoga olearia
           TBF 19.5.1 RepID=C5CJ10_KOSOT
          Length = 417

 Score =  110 bits (275), Expect = 8e-23
 Identities = 71/193 (36%), Positives = 105/193 (54%), Gaps = 2/193 (1%)
 Frame = +1

Query: 1   PDSITYKYLE--GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC 174
           PD  T  +L   G+ S  Y  + SD  A +   Y  DV+ LEP VA PH+ DN     E 
Sbjct: 225 PDEKTRAFLRAYGRES-DYREIKSDPDAVYEKIYEIDVSNLEPAVALPHTVDNTKSISEV 283

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPG 354
           + +KI++V+IG+CT G+ ED   AA + L    K   V   ++PA+++V++         
Sbjct: 284 EGIKIDQVFIGTCTNGRLEDLRVAASI-LKGREKHPDVRLIVIPASKEVYLKALE----- 337

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +   +IF E+G  T  +P CG C+G  +     + + +  +ST NRNF GRMG+ + 
Sbjct: 338 ---EGLIKIFVESGA-TVLAPGCGPCVGVHQGV---LGDGERVLSTQNRNFKGRMGNPKA 390

Query: 535 EIYLVSPYTAAAS 573
           EI+L SP TAAAS
Sbjct: 391 EIFLASPATAAAS 403

[222][TOP]
>UniRef100_C8PKG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           gracilis RM3268 RepID=C8PKG7_9PROT
          Length = 421

 Score =  110 bits (275), Expect = 8e-23
 Identities = 77/195 (39%), Positives = 106/195 (54%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKT-SVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-- 174
           D IT ++L  K      +  YSD+ A +    + DV+KL+P++A P  P N    RE   
Sbjct: 230 DEITKEFLADKNLRAEPKFHYSDEGANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVR 289

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPV 348
            D+ +++V+IGSCT G+  D   AA++     G+KV   T L+  PATQK+     +L  
Sbjct: 290 DDIAVDQVFIGSCTNGRLSDLRIAAQILK---GRKVARKTRLIITPATQKI-----ALAA 341

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
              G      IF EAG    ++P+CGACLGG       +   + CVSTTNRNF GRMG R
Sbjct: 342 QKEG---LWDIFVEAGA-VVSNPTCGACLGGYMGI---LGVGERCVSTTNRNFVGRMGDR 394

Query: 529 EGEIYLVSPYTAAAS 573
             E+YL +   AAAS
Sbjct: 395 TSEVYLANSAVAAAS 409

[223][TOP]
>UniRef100_A8EQZ0 3-isopropylmalate dehydratase large subunit n=1 Tax=Arcobacter
           butzleri RM4018 RepID=LEUC_ARCB4
          Length = 426

 Score =  110 bits (275), Expect = 8e-23
 Identities = 68/175 (38%), Positives = 99/175 (56%), Gaps = 4/175 (2%)
 Frame = +1

Query: 61  YSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKD-VKINRVYIGSCTGGKTED 234
           YSD+ A +      DV KLEP++A P+ P N  ++++   D +K+++V+IGSCT G+  D
Sbjct: 255 YSDEDANYCQVIEIDVAKLEPVIAYPYLPSNGHSVSQAVSDNIKVDQVFIGSCTNGRLSD 314

Query: 235 FMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTP 408
           F  AA++     G+KV   V   L P TQK+  +   L    +          +AG    
Sbjct: 315 FKIAAEIL---AGQKVARHVRLILTPGTQKILREATKLGYIDT--------LVDAGA-VV 362

Query: 409 ASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
           ++P+CGACLGG       + + +VC+STTNRNF GRMG R  +IYL +   AAAS
Sbjct: 363 SNPTCGACLGGYMGI---LGDNEVCISTTNRNFVGRMGSRSSKIYLANSAVAAAS 414

[224][TOP]
>UniRef100_C3RJS7 Putative uncharacterized protein n=1 Tax=Mollicutes bacterium D7
           RepID=C3RJS7_9MOLU
          Length = 422

 Score =  110 bits (274), Expect = 1e-22
 Identities = 75/195 (38%), Positives = 100/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T  Y+E  +   Y    +D+ A +      D+ K+ P VA PH P N     E +  
Sbjct: 228 DEQTIAYMEKHSVKEYAVYEADEDAEYDEVIEIDLGKVRPTVAFPHLPGNGHTIDEIEAM 287

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPV 348
             + I++V IGSCT G+  D   AA +     GK+V   V   +VPATQK+++       
Sbjct: 288 DKIMIDQVVIGSCTNGRLSDLRKAAAILK---GKQVAKNVRVMVVPATQKIFVQCIH--- 341

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +  ++IF EAGC    +PSCG C+GG     A+  +   CVSTTNRNF GRMG  
Sbjct: 342 -----EGLAEIFVEAGCAFN-TPSCGPCMGGHMGVMAKGEK---CVSTTNRNFVGRMGDT 392

Query: 529 EGEIYLVSPYTAAAS 573
           E  IYL SP  AAAS
Sbjct: 393 EALIYLASPEVAAAS 407

[225][TOP]
>UniRef100_B0N943 Putative uncharacterized protein n=1 Tax=Clostridium ramosum DSM
           1402 RepID=B0N943_9FIRM
          Length = 424

 Score =  110 bits (274), Expect = 1e-22
 Identities = 75/195 (38%), Positives = 100/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T  Y+E  +   Y    +D+ A +      D+ K+ P VA PH P N     E +  
Sbjct: 230 DEQTIAYMEKHSVKEYAVYEADEDAEYDEVIEIDLGKVRPTVAFPHLPGNGHTIDEIEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPV 348
             + I++V IGSCT G+  D   AA +     GK+V   V   +VPATQK+++       
Sbjct: 290 DKIMIDQVVIGSCTNGRLSDLRKAAAILK---GKQVAKNVRVMVVPATQKIFVQCIH--- 343

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +  ++IF EAGC    +PSCG C+GG     A+  +   CVSTTNRNF GRMG  
Sbjct: 344 -----EGLAEIFVEAGCAFN-TPSCGPCMGGHMGVMAKGEK---CVSTTNRNFVGRMGDT 394

Query: 529 EGEIYLVSPYTAAAS 573
           E  IYL SP  AAAS
Sbjct: 395 EALIYLASPEVAAAS 409

[226][TOP]
>UniRef100_A6NUW5 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6NUW5_9BACE
          Length = 422

 Score =  110 bits (274), Expect = 1e-22
 Identities = 70/192 (36%), Positives = 101/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +T  YL G+ +  +E+  +D  A +  E   D+ +L P VA PH P N     + + +
Sbjct: 231 DDVTRAYLNGRVTREWEAFEADPDAVYEREVVIDLDQLRPTVALPHLPSNTRTVDQVEGM 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            I +V IGSCT G+ +D   AA++     G+KV   V   + PATQ++ +D  +      
Sbjct: 291 PIQQVVIGSCTNGRLKDIKEAAEIL---KGRKVAKGVRCIVFPATQQIMLDAMAAGY--- 344

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                 Q   EAGC   ++P+CG CLGG       +++ +  +STTNRNF GRMG    E
Sbjct: 345 -----IQTLVEAGC-AVSTPTCGPCLGGHMGV---LSDGERAISTTNRNFVGRMGPVSSE 395

Query: 538 IYLVSPYTAAAS 573
           I L SP  AAAS
Sbjct: 396 IILSSPAVAAAS 407

[227][TOP]
>UniRef100_C2A003 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurospirillum deleyianum DSM 6946
           RepID=C2A003_SULDE
          Length = 421

 Score =  109 bits (273), Expect = 1e-22
 Identities = 78/195 (40%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-- 174
           D IT  +L  K         YSD  A ++     DV  L+P++A P  P N     E   
Sbjct: 230 DEITKAFLSDKNLAREPKFFYSDDDATYVQVLHIDVANLDPVIAYPFLPSNGKSINEAVK 289

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPV 348
            D+ I++V+IGSCT G+ ED   AA +     G+KV   T L+  PATQK+     SL  
Sbjct: 290 DDLAIDQVFIGSCTNGRLEDLRIAASILK---GRKVARKTRLIITPATQKI-----SLQA 341

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
              G     +IF EAG    ++P+CGACLGG       + + + CV+TTNRNF GRMG R
Sbjct: 342 QKEG---LVEIFIEAGA-VFSNPTCGACLGGYMGI---LGKNERCVATTNRNFVGRMGDR 394

Query: 529 EGEIYLVSPYTAAAS 573
             EIYL +   AAAS
Sbjct: 395 TSEIYLANSAVAAAS 409

[228][TOP]
>UniRef100_B6FST2 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM
           1787 RepID=B6FST2_9CLOT
          Length = 438

 Score =  109 bits (273), Expect = 1e-22
 Identities = 72/189 (38%), Positives = 99/189 (52%), Gaps = 5/189 (2%)
 Frame = +1

Query: 22  YLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD---VKIN 192
           Y++  +   Y+   +D+ A +      D++K+ P VA PH P N     E ++   +KI+
Sbjct: 250 YMKEHSEKEYKVYTADEDAEYDEVVEIDLSKVRPTVAFPHLPGNAKTIDEVEEMEPIKID 309

Query: 193 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGK 366
           +V IGSCT G+ ED   AA V     G KV   V   ++PATQK+++            +
Sbjct: 310 QVVIGSCTNGRMEDMRRAAAVLK---GHKVHPDVRVMVIPATQKIYLQCIE--------E 358

Query: 367 TCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYL 546
                F E+GC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH +  IYL
Sbjct: 359 GLVTTFIESGCAFN-TPSCGPCMGGHMGVMAAGEK---CVSTTNRNFVGRMGHVDSLIYL 414

Query: 547 VSPYTAAAS 573
            SP  AAAS
Sbjct: 415 ASPEVAAAS 423

[229][TOP]
>UniRef100_B0A9M7 Putative uncharacterized protein n=1 Tax=Clostridium bartlettii DSM
           16795 RepID=B0A9M7_9CLOT
          Length = 429

 Score =  109 bits (273), Expect = 1e-22
 Identities = 76/197 (38%), Positives = 102/197 (51%), Gaps = 7/197 (3%)
 Frame = +1

Query: 4   DSITYKYLEG---KTSVPYESVY-SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE 171
           D  T +Y+E    KT     +VY +D+ A +      D+++L+P VA PH P+N     E
Sbjct: 231 DEKTKEYMEAHPCKTIEKNPTVYEADEDAEYDRVIEIDLSELKPTVAFPHLPENTKTTDE 290

Query: 172 C-KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSL 342
             +D+KI++V IGSCT G+ ED   AA++     GKKV   V   + P TQ ++++    
Sbjct: 291 ITEDIKIDQVVIGSCTNGRIEDMRIAAEIMR---GKKVADDVRCIVFPGTQAIYLEAIEK 347

Query: 343 PVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMG 522
                 G     +   A   TP   +CG CLGG     A        VSTTNRNF GRMG
Sbjct: 348 ------GYITDMVLAGAAISTP---TCGPCLGGHMGILAAGER---AVSTTNRNFVGRMG 395

Query: 523 HREGEIYLVSPYTAAAS 573
           H E E+YL SP  AAAS
Sbjct: 396 HTESEVYLASPAVAAAS 412

[230][TOP]
>UniRef100_C8SBC1 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SBC1_FERPL
          Length = 427

 Score =  109 bits (273), Expect = 1e-22
 Identities = 71/193 (36%), Positives = 102/193 (52%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYL-EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           D +T K+L E      +  +  D+ A +  E  FDV+ L P+VAKPH  DN A   E + 
Sbjct: 237 DEVTKKFLMERGRGDKFREIKPDEDAEYEKEMYFDVSDLTPIVAKPHQVDNIARIDEVEG 296

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPG 354
           VK+++V++G+CT G+  D    A++     G+KV   V   + PA+++V+M         
Sbjct: 297 VKVDQVFVGTCTNGRLSDLEVVARIL---KGRKVHKDVRLLVGPASREVYMKALERGY-- 351

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
                  +I +  G   P  P CG C+G      A   + +VC+ST NRNF GRMG+   
Sbjct: 352 -----IQEIIKAGGVILP--PGCGPCVGIHLGILA---DGEVCLSTQNRNFKGRMGNPNA 401

Query: 535 EIYLVSPYTAAAS 573
           EIYL SP TAAAS
Sbjct: 402 EIYLSSPATAAAS 414

[231][TOP]
>UniRef100_C5U5J5 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           infernus ME RepID=C5U5J5_9EURY
          Length = 416

 Score =  109 bits (273), Expect = 1e-22
 Identities = 71/199 (35%), Positives = 103/199 (51%), Gaps = 9/199 (4%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV-------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRAL 162
           D IT+ YL  +  +  E +          ++  ++ E   D+T++E  +A PHSPDN   
Sbjct: 223 DEITFNYLREERGLSEEKINKLKREAIKVEEGNYIKEIFIDITEMEEQIALPHSPDNVKP 282

Query: 163 ARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVY 336
             E + ++I++V+IGSCT G+ ED    AK      GKKV   V   ++PA++KV++   
Sbjct: 283 ISEVEGLEIDQVFIGSCTNGRIEDLRIVAKYL---KGKKVHKDVKLIIIPASKKVYLKAL 339

Query: 337 SLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGR 516
                    +   +IF +AG      P CG CLG  +   A   E +VC+ST+NRNF GR
Sbjct: 340 K--------EGLIEIFIKAGA-MICPPGCGPCLGAHQGVLA---EGEVCLSTSNRNFRGR 387

Query: 517 MGHREGEIYLVSPYTAAAS 573
           MG     IYL SP  AA S
Sbjct: 388 MGDPNSYIYLCSPKIAAIS 406

[232][TOP]
>UniRef100_Q7VH31 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           hepaticus RepID=LEUC_HELHP
          Length = 420

 Score =  109 bits (273), Expect = 1e-22
 Identities = 66/190 (34%), Positives = 98/190 (51%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D IT  Y +G+T   +    +D  A +   +  D+  +   VA PH P+N     +  ++
Sbjct: 231 DDITISYAKGRTKRDFRIYKADVDAEYEQVFDIDLDSINHTVAFPHLPENTKEKDDWGEI 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGG 363
           KI++V IGSCT G+  D   AA++       K      ++PATQ ++++  +        
Sbjct: 291 KIDQVVIGSCTNGRLSDMAVAAEILKDKTIAK-NTRCIIIPATQNIYLECIN-------- 341

Query: 364 KTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIY 543
           +   + F +AG    ++P+CG CLGG     A   +   CVSTTNRNF GRMGH   E+Y
Sbjct: 342 RGYLETFIKAGA-VVSTPTCGPCLGGHMGILAANEK---CVSTTNRNFVGRMGHITSEVY 397

Query: 544 LVSPYTAAAS 573
           L SP  AAAS
Sbjct: 398 LSSPEVAAAS 407

[233][TOP]
>UniRef100_B5CQV8 Putative uncharacterized protein n=1 Tax=Ruminococcus lactaris ATCC
           29176 RepID=B5CQV8_9FIRM
          Length = 424

 Score =  109 bits (272), Expect = 2e-22
 Identities = 73/193 (37%), Positives = 96/193 (49%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D  T  YL       Y    +D+ A +      D++K+ P VA PH P N     E +  
Sbjct: 230 DEKTKAYLAEHCKKEYTVYEADEDAVYDEVIEIDLSKVRPTVAFPHLPGNAKTIDEVEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPG 354
             +KI++V IGSCT G+ ED   AA + L        V   ++PATQK++ +        
Sbjct: 290 EPIKIDQVVIGSCTNGRMEDLRKAAAI-LKGHTVHPDVRVMVIPATQKIYKECIK----- 343

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +    IF +AGC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH + 
Sbjct: 344 ---EGLLDIFVDAGCAVN-TPSCGPCMGGHMGVMAAGEK---CVSTTNRNFVGRMGHVDS 396

Query: 535 EIYLVSPYTAAAS 573
            IYL SP  AAAS
Sbjct: 397 LIYLASPEVAAAS 409

[234][TOP]
>UniRef100_B0NJ74 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC
           35704 RepID=B0NJ74_EUBSP
          Length = 424

 Score =  109 bits (272), Expect = 2e-22
 Identities = 74/195 (37%), Positives = 100/195 (51%), Gaps = 5/195 (2%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-- 177
           D    +Y++  +   Y+   +D  A + +    D+ K+ P VA PH P N     E +  
Sbjct: 230 DEKAEEYMKEHSDKEYKIYEADADADYDAVVEVDLAKVRPTVAFPHLPGNAKTIDEIEAM 289

Query: 178 -DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPV 348
             +KI++V IGSCT G+ ED   AA V     G+KV   V   ++PATQK++        
Sbjct: 290 EPIKIDQVVIGSCTNGRMEDMRRAAAVLK---GRKVHPDVRVMVIPATQKIYKQCIK--- 343

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +    IF +AGC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH 
Sbjct: 344 -----EGLVDIFIDAGCAFN-TPSCGPCMGGHMGVLAAGEK---CVSTTNRNFVGRMGHV 394

Query: 529 EGEIYLVSPYTAAAS 573
           +  IYL SP  AAAS
Sbjct: 395 DSLIYLASPEVAAAS 409

[235][TOP]
>UniRef100_Q7M9Z9 3-isopropylmalate dehydratase large subunit n=1 Tax=Wolinella
           succinogenes RepID=LEUC_WOLSU
          Length = 422

 Score =  109 bits (272), Expect = 2e-22
 Identities = 73/196 (37%), Positives = 108/196 (55%), Gaps = 6/196 (3%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVY--SDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALAREC 174
           DSIT ++L  + S+  E  Y  +D  A +      DV KLEP++A P  P N +++++  
Sbjct: 230 DSITKEFLASRKSLRAEPKYYQADADALYEQTIEIDVEKLEPVIAYPFLPSNGKSISQAV 289

Query: 175 KD-VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLP 345
           KD +KI++ +IGSCT G+  D   AA++     GK+V   V   + P TQ+++ D +   
Sbjct: 290 KDDLKIDQAFIGSCTNGRLSDLRIAAQILK---GKRVHPDVRLIITPGTQQIYKDAHQ-- 344

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                 +       EAG    ++P+CGACLGG       + + + CVSTTNRNF GRMG 
Sbjct: 345 ------EGLIDTLLEAGA-LISNPTCGACLGGYMGI---LGDNERCVSTTNRNFVGRMGA 394

Query: 526 REGEIYLVSPYTAAAS 573
           R  E+YL +   AAAS
Sbjct: 395 RSSEVYLANSAVAAAS 410

[236][TOP]
>UniRef100_C0BZF9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0BZF9_9CLOT
          Length = 431

 Score =  108 bits (271), Expect = 2e-22
 Identities = 74/189 (39%), Positives = 98/189 (51%), Gaps = 5/189 (2%)
 Frame = +1

Query: 22  YLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK---DVKIN 192
           Y++  +   Y    +D+ A +      D++K+ P VA PH P N     E +    V+I+
Sbjct: 243 YMKEHSDKSYTIYEADEDAVYDEVVEIDLSKVRPTVAFPHLPGNAKTIDEIEAMEPVRID 302

Query: 193 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGK 366
           +V IGSCT G+ ED   AA V     G KV   V   ++PATQK++    S        +
Sbjct: 303 QVVIGSCTNGRMEDMRRAAAVLK---GHKVHPDVRAMIIPATQKIYKQCIS--------E 351

Query: 367 TCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYL 546
               IF +AGC    +PSCG C+GG     A   +   CVSTTNRNF GRMGH +  IYL
Sbjct: 352 GLVDIFIDAGCAFN-TPSCGPCMGGHMGVLAAGEK---CVSTTNRNFVGRMGHVDSLIYL 407

Query: 547 VSPYTAAAS 573
            SP  AAAS
Sbjct: 408 ASPEVAAAS 416

[237][TOP]
>UniRef100_C0B4W1 Putative uncharacterized protein n=1 Tax=Coprococcus comes ATCC
           27758 RepID=C0B4W1_9FIRM
          Length = 417

 Score =  108 bits (271), Expect = 2e-22
 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D +  +YL+     P    +SD  A ++ EY FD++K+EP+VAKP   DN A A++ + +
Sbjct: 229 DDVAMEYLKEHGREPKAVYHSDPDAHYVREYTFDLSKVEPVVAKPDFVDNLAPAKDVRGI 288

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI+  ++GSC  G+ ED    A+V     GKKV  KV   +VPA+Q ++           
Sbjct: 289 KIDEAFLGSCNNGRIEDLRVGAQVI---KGKKVSEKVRFLVVPASQTIYRQALE------ 339

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +    IF +AG     +P+C  C G  +     + E +V +ST  RNF GR GH   +
Sbjct: 340 --EGLIDIFMDAGA-IVMNPNCSVCWGSCQGV---IGENEVLISTGTRNFKGRAGHPSSK 393

Query: 538 IYLVSPYTAAAS 573
           +YL S  T  AS
Sbjct: 394 VYLGSAATVTAS 405

[238][TOP]
>UniRef100_A1VAE7 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           vulgaris DP4 RepID=LEUC_DESVV
          Length = 419

 Score =  108 bits (271), Expect = 2e-22
 Identities = 75/192 (39%), Positives = 99/192 (51%), Gaps = 3/192 (1%)
 Frame = +1

Query: 7   SITYKYLEGKTSVPYESVYS-DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           ++TY    G+T    ++ +S D  A +  E  FDVT + P+VA PH PDN     E KDV
Sbjct: 234 TLTYCTAAGRTG---DAAFSADAGAVYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            + +V IGSCT G+  D   AA V     G+KV   V   ++PAT  +W           
Sbjct: 291 TVQQVVIGSCTNGRIGDLREAAAVL---RGRKVSRDVRCIVLPATPGIWRQALR------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAGC      +CG CLGG     A   + +  ++TTNRNF GRMG  E E
Sbjct: 342 --EGLIETFMEAGC-IVGPATCGPCLGGHMGILA---DGERAIATTNRNFKGRMGSLESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL  P TAAAS
Sbjct: 396 VYLSGPATAAAS 407

[239][TOP]
>UniRef100_Q726X4 3-isopropylmalate dehydratase large subunit n=2 Tax=Desulfovibrio
           vulgaris RepID=LEUC_DESVH
          Length = 419

 Score =  108 bits (271), Expect = 2e-22
 Identities = 75/192 (39%), Positives = 99/192 (51%), Gaps = 3/192 (1%)
 Frame = +1

Query: 7   SITYKYLEGKTSVPYESVYS-DQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           ++TY    G+T    ++ +S D  A +  E  FDVT + P+VA PH PDN     E KDV
Sbjct: 234 TLTYCTTAGRTG---DTAFSADAGAVYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDV 290

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGS 357
            + +V IGSCT G+  D   AA V     G+KV   V   ++PAT  +W           
Sbjct: 291 TVQQVVIGSCTNGRIGDLREAAAVL---RGRKVSRDVRCIVLPATPGIWRQALR------ 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
             +   + F EAGC      +CG CLGG     A   + +  ++TTNRNF GRMG  E E
Sbjct: 342 --EGLIETFMEAGC-IVGPATCGPCLGGHMGILA---DGERAIATTNRNFKGRMGSLESE 395

Query: 538 IYLVSPYTAAAS 573
           +YL  P TAAAS
Sbjct: 396 VYLSGPATAAAS 407

[240][TOP]
>UniRef100_O28316 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Archaeoglobus
           fulgidus RepID=LEUC1_ARCFU
          Length = 418

 Score =  108 bits (271), Expect = 2e-22
 Identities = 74/195 (37%), Positives = 106/195 (54%), Gaps = 4/195 (2%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYES--VYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC 174
           PD  T +YL+     PYE   + SD+ A F  E   DVT +EP VA PH  DN     E 
Sbjct: 228 PDKTTLEYLKAMGR-PYEGELLKSDEDAEF-QEVELDVTGMEPQVAAPHRVDNVVGISEV 285

Query: 175 KDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPV 348
           +  ++++V+IGSCT G+ ED   AA++     G+KV   V   ++PA+ + +        
Sbjct: 286 EGTRVDQVFIGSCTNGRYEDLKIAAEIL---KGEKVASNVRLIVIPASHREYRRALK--- 339

Query: 349 PGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHR 528
                +   +IF +AG    A P CG C+GG   ++  +   +V VST+NRNF GR G  
Sbjct: 340 -----EGLIEIFVDAGALVEA-PCCGPCMGG---SFGLIASGEVSVSTSNRNFIGRQGSP 390

Query: 529 EGEIYLVSPYTAAAS 573
           EG+IYLV+P  AAA+
Sbjct: 391 EGKIYLVNPAVAAAT 405

[241][TOP]
>UniRef100_Q1IZK5 3-isopropylmalate dehydratase large subunit n=1 Tax=Deinococcus
           geothermalis DSM 11300 RepID=Q1IZK5_DEIGD
          Length = 431

 Score =  108 bits (270), Expect = 3e-22
 Identities = 73/194 (37%), Positives = 96/194 (49%), Gaps = 8/194 (4%)
 Frame = +1

Query: 16  YKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINR 195
           Y    G T   Y    SD  AR+      D +K+EP VA PH P N  +A + + + I  
Sbjct: 237 YMAARGVTPDQYTEYTSDPDARYKVVIDLDASKVEPTVAYPHIPSNGRVAGQDR-IPITH 295

Query: 196 VYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKT 369
            Y+GSCT G+  D    A++     G++V   V   +VPATQ +W          +  + 
Sbjct: 296 AYVGSCTNGRIGDLRDVARILK---GRRVADGVQMIVVPATQAIWKQ--------AAQEG 344

Query: 370 CSQIFEEAGCDTPASPSCGACLG------GPKDTYARMNEPQVCVSTTNRNFPGRMGHRE 531
             +IF EAG    + PSCGACLG      GP D         VC+S++NRNF GRMG   
Sbjct: 345 LLEIFVEAGASV-SYPSCGACLGMHSGVLGPGD---------VCISSSNRNFVGRMGDPS 394

Query: 532 GEIYLVSPYTAAAS 573
            +IYL SP T AAS
Sbjct: 395 AQIYLASPATVAAS 408

[242][TOP]
>UniRef100_B8GJ01 Homoaconitate hydratase family protein n=1 Tax=Methanosphaerula
           palustris E1-9c RepID=B8GJ01_METPE
          Length = 419

 Score =  108 bits (270), Expect = 3e-22
 Identities = 67/191 (35%), Positives = 99/191 (51%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 180
           PD +T+ YL+ +  V    + SD+ A F  + R+DVT L P VA PH+ D+     E   
Sbjct: 230 PDQVTWDYLKSRRQVTPFELDSDEDATFADQRRYDVTNLVPKVAVPHNVDHVVDVTEVAG 289

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSG 360
             +++V+IGSCT G+ ED   AA V L        +   ++PA++  ++      +    
Sbjct: 290 THLDQVFIGSCTNGRFEDLAEAAAV-LGDRNFSEDLRVLVIPASRDEYLKTLRAGL---- 344

Query: 361 GKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEI 540
                + F EAG    A P CG C+GG   ++  +   +  +ST+NRNF GR G  EG +
Sbjct: 345 ----IERFVEAGAMVEA-PCCGPCMGG---SFGLIGPGEASLSTSNRNFRGRQGSAEGSV 396

Query: 541 YLVSPYTAAAS 573
           YL S  TAAAS
Sbjct: 397 YLASAATAAAS 407

[243][TOP]
>UniRef100_Q18AJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile 630 RepID=LEUC_CLOD6
          Length = 425

 Score =  108 bits (270), Expect = 3e-22
 Identities = 70/173 (40%), Positives = 93/173 (53%), Gaps = 3/173 (1%)
 Frame = +1

Query: 64  SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYIGSCTGGKTEDFM 240
           +D+ A +   Y  D+ KL+  VA PH P+N     E  KD+KI++V IGSCT G+  D  
Sbjct: 255 ADEDAVYDEVYEIDLAKLKETVAFPHLPENTRTVDEIDKDIKIDQVVIGSCTNGRISDLE 314

Query: 241 AAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTPAS 414
             A++     GKKV   V   + P TQKV+++           K     F EAG    ++
Sbjct: 315 VVAEIMK---GKKVADGVRVMIFPGTQKVYLEAIE--------KGYITTFIEAGAAV-ST 362

Query: 415 PSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGEIYLVSPYTAAAS 573
           P+CG CLGG     A   +    +STTNRNF GRMGH + E+YL SP  AAAS
Sbjct: 363 PTCGPCLGGHMGILAAGEKS---ISTTNRNFVGRMGHVDSEVYLASPAVAAAS 412

[244][TOP]
>UniRef100_UPI0001B0C0E1 homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           vulcanius M7 RepID=UPI0001B0C0E1
          Length = 449

 Score =  108 bits (269), Expect = 4e-22
 Identities = 70/199 (35%), Positives = 100/199 (50%), Gaps = 9/199 (4%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV---------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNR 156
           D ITY YL+ +  +  + +          +  +A +  E   D+T +E  +A PH PDN 
Sbjct: 254 DEITYNYLKKERGLSDDDINKLKKERITVNKDEANYHKEVVIDITDMEEQIAVPHHPDNV 313

Query: 157 ALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVY 336
               E     I++V+IGSCT G+ ED   AAK +L        V   ++PA++KV++   
Sbjct: 314 KPVSEVAGKAIDQVFIGSCTNGRLEDLREAAK-YLKGRRVHEDVKLIVIPASKKVFLQAL 372

Query: 337 SLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGR 516
                    +   ++F +AG     +P CG CLG  +   A   E +VC+STTNRNF GR
Sbjct: 373 K--------EGIIEVFIKAGA-MICTPGCGPCLGAHQGVLA---EGEVCLSTTNRNFRGR 420

Query: 517 MGHREGEIYLVSPYTAAAS 573
           MGH    IYL SP  AA S
Sbjct: 421 MGHINSYIYLSSPKIAAIS 439

[245][TOP]
>UniRef100_UPI000038E0FA 3-isopropylmalate dehydratase large subunit n=1 Tax=Ferroplasma
           acidarmanus fer1 RepID=UPI000038E0FA
          Length = 413

 Score =  108 bits (269), Expect = 4e-22
 Identities = 69/192 (35%), Positives = 103/192 (53%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T +YL  + +  Y+ V SD+ A F   +  D+  +EP +A P+SPDN  +A    + 
Sbjct: 226 DEKTIEYLNQRNTGSYKIVKSDENADFSQTFNIDMNNIEPSIAIPNSPDNVRIASAIHE- 284

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
           KI++ YIGSCT G+ ED   AA +     G+KV   V   +VPA+Q+V+       +   
Sbjct: 285 KIDQAYIGSCTNGRIEDIRKAAAIL---KGRKVNRNVRLMVVPASQEVYNQALREGL--- 338

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                + I E  G    +  +CGACLGG       +   +VC+S+TNRNF GRMG +  +
Sbjct: 339 ----INTIVEAGGYF--SGTTCGACLGGYMGV---LGPDEVCISSTNRNFIGRMGDKTSK 389

Query: 538 IYLVSPYTAAAS 573
           +YL +P   A+S
Sbjct: 390 VYLANPSIVASS 401

[246][TOP]
>UniRef100_C5ZZ28 3-isopropylmalate dehydratase, large subunit n=1 Tax=Helicobacter
           canadensis MIT 98-5491 RepID=C5ZZ28_9HELI
          Length = 421

 Score =  108 bits (269), Expect = 4e-22
 Identities = 70/196 (35%), Positives = 109/196 (55%), Gaps = 6/196 (3%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYE--SVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALAREC 174
           D IT ++L  +  +  +    YSD+ A +    + D++ LEP++A P  P N +++++  
Sbjct: 230 DEITREFLASRKELRAKPKEFYSDKDANYTRVLKIDISTLEPVIAYPFLPSNGKSISQAL 289

Query: 175 KD-VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLP 345
           KD +KI++V+IGSCT G+  D   A+++     GKKV   V   + P TQ+++ + Y L 
Sbjct: 290 KDDLKIDQVFIGSCTNGRLADLKIASEILK---GKKVHKDVRLIVTPGTQQIYKEAYQLG 346

Query: 346 VPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGH 525
                      I  E+G    ++P+CGACLGG       + + + CVSTTNRNF GRMG 
Sbjct: 347 Y--------IDILLESGA-LISNPTCGACLGGYMGI---LGDNERCVSTTNRNFVGRMGA 394

Query: 526 REGEIYLVSPYTAAAS 573
           R  E+YL +   AA S
Sbjct: 395 RSSEVYLANSAVAAMS 410

[247][TOP]
>UniRef100_C3XJX6 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           winghamensis ATCC BAA-430 RepID=C3XJX6_9HELI
          Length = 422

 Score =  108 bits (269), Expect = 4e-22
 Identities = 71/197 (36%), Positives = 109/197 (55%), Gaps = 6/197 (3%)
 Frame = +1

Query: 1   PDSITYKYLEGKTSVPYE--SVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARE 171
           PDSIT ++L  ++++  +    +SD  A +      D++KLEP+VA P  P N + +++ 
Sbjct: 229 PDSITREFLASRSNLRAKPKEFFSDIDANYTRTLTIDISKLEPVVAYPFLPSNGKNISQA 288

Query: 172 CKD-VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSL 342
            KD +KI++ +IGSCT G+  D   A+++     GKKV   V   + P TQ+++ D + L
Sbjct: 289 VKDNLKIDQAFIGSCTNGRLSDLKIASEILK---GKKVHKDVRLIITPGTQQIYKDAHKL 345

Query: 343 PVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMG 522
                       I  +AG    ++P+CGACLGG       + + + CVSTTNRNF GRMG
Sbjct: 346 GY--------IDILLDAGA-LISNPTCGACLGGYMGI---LGDNERCVSTTNRNFIGRMG 393

Query: 523 HREGEIYLVSPYTAAAS 573
            R  E+YL +    A S
Sbjct: 394 ARNSEVYLANSAVVAIS 410

[248][TOP]
>UniRef100_B0MLF2 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM
           15702 RepID=B0MLF2_9FIRM
          Length = 418

 Score =  108 bits (269), Expect = 4e-22
 Identities = 67/193 (34%), Positives = 102/193 (52%), Gaps = 3/193 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KD 180
           D IT  Y++ +    ++   +D+ A +      D++ ++  V+ PH P+N     E  +D
Sbjct: 231 DEITMAYMKERADRDFDIFKADEDAVYSRVIDIDLSTVKQTVSFPHLPENTKTVDEITED 290

Query: 181 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPG 354
           +KI++  IGSCT G+  D   AA++     GK +   V   ++P TQKV++         
Sbjct: 291 IKIDQAVIGSCTNGRISDMRIAAEILK---GKHIAKGVRCIVIPGTQKVYLQCIK----- 342

Query: 355 SGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREG 534
              +  ++IF  AGC   ++P+CG CLGG     A        +STTNRNF GRMGH + 
Sbjct: 343 ---EGLAEIFVNAGC-VLSTPTCGPCLGGHMGILAAGER---AISTTNRNFVGRMGHVDS 395

Query: 535 EIYLVSPYTAAAS 573
           E+YL SP  AAAS
Sbjct: 396 EVYLASPAVAAAS 408

[249][TOP]
>UniRef100_C9RHV4 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           vulcanius M7 RepID=C9RHV4_9EURY
          Length = 419

 Score =  108 bits (269), Expect = 4e-22
 Identities = 70/199 (35%), Positives = 100/199 (50%), Gaps = 9/199 (4%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESV---------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNR 156
           D ITY YL+ +  +  + +          +  +A +  E   D+T +E  +A PH PDN 
Sbjct: 224 DEITYNYLKKERGLSDDDINKLKKERITVNKDEANYHKEVVIDITDMEEQIAVPHHPDNV 283

Query: 157 ALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVY 336
               E     I++V+IGSCT G+ ED   AAK +L        V   ++PA++KV++   
Sbjct: 284 KPVSEVAGKAIDQVFIGSCTNGRLEDLREAAK-YLKGRRVHEDVKLIVIPASKKVFLQAL 342

Query: 337 SLPVPGSGGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGR 516
                    +   ++F +AG     +P CG CLG  +   A   E +VC+STTNRNF GR
Sbjct: 343 K--------EGIIEVFIKAGA-MICTPGCGPCLGAHQGVLA---EGEVCLSTTNRNFRGR 390

Query: 517 MGHREGEIYLVSPYTAAAS 573
           MGH    IYL SP  AA S
Sbjct: 391 MGHINSYIYLSSPKIAAIS 409

[250][TOP]
>UniRef100_A4J6Z5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum reducens MI-1 RepID=A4J6Z5_DESRM
          Length = 418

 Score =  107 bits (268), Expect = 5e-22
 Identities = 68/192 (35%), Positives = 98/192 (51%), Gaps = 2/192 (1%)
 Frame = +1

Query: 4   DSITYKYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDV 183
           D  T+ +L+  T   + +V +D  A +      DV+ LEP VAKPH  DN +   E K +
Sbjct: 228 DDKTFAWLKQYTERQFTAVSADANANYYKVLELDVSNLEPQVAKPHRVDNVSPLSEVKGL 287

Query: 184 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGS 357
            I + ++G+CT G+ ED   AA +     GKKV   V   + PA++K++++     V   
Sbjct: 288 PIQQAFLGTCTNGRLEDLRIAASIL---AGKKVHPDVRFIVAPASRKIYLEAMEEGV--- 341

Query: 358 GGKTCSQIFEEAGCDTPASPSCGACLGGPKDTYARMNEPQVCVSTTNRNFPGRMGHREGE 537
                 Q   EAG     +P CG C+G         ++ +  +ST NRNF GRMG+   E
Sbjct: 342 -----IQRLVEAGA-AVVTPGCGPCVGTHNGV---PSDGETVISTANRNFKGRMGNSNAE 392

Query: 538 IYLVSPYTAAAS 573
           IYL SP T AAS
Sbjct: 393 IYLASPATVAAS 404