[UP]

[1][TOP]
>UniRef100_B9SQS5 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS5_RICCO
          Length = 510

 Score =  357 bits (916), Expect = 4e-97
 Identities = 177/192 (92%), Positives = 186/192 (96%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVG+TVESLNMEERMTLCNMVVEAGGKNGVIP DS T+KYL
Sbjct: 256 ILQIIGEISVSGATYKSMEFVGTTVESLNMEERMTLCNMVVEAGGKNGVIPSDSTTFKYL 315

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KTSVP+E VYSD++ARFLSEYRFDV+KLEPLVAKPHSPDN ALARECKDVKI+RVYIG
Sbjct: 316 EDKTSVPFEPVYSDEKARFLSEYRFDVSKLEPLVAKPHSPDNCALARECKDVKIDRVYIG 375

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDFMAAAKVFLAS GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE
Sbjct: 376 SCTGGKTEDFMAAAKVFLAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 434

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 435 EAGCDTPASPSC 446

[2][TOP]
>UniRef100_UPI0001983BAD PREDICTED: similar to Os02g0125100 n=1 Tax=Vitis vinifera
           RepID=UPI0001983BAD
          Length = 508

 Score =  354 bits (908), Expect = 3e-96
 Identities = 175/192 (91%), Positives = 183/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P DS T+KYL
Sbjct: 254 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYL 313

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KT VPYE VYSD+QARFLSEYRFDV+KLEPLVAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 314 EDKTDVPYEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIG 373

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVF AS GKKVKVPTFLVPATQKVWMDVYSLPVPG GGKTCSQIFE
Sbjct: 374 SCTGGKTEDFLAAAKVFHAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGCGGKTCSQIFE 432

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 433 EAGCDTPASPSC 444

[3][TOP]
>UniRef100_B9HSU8 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HSU8_POPTR
          Length = 462

 Score =  354 bits (908), Expect = 3e-96
 Identities = 173/192 (90%), Positives = 184/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+VAGATYKSMEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P DS T+KYL
Sbjct: 208 ILQIIGEISVAGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTFKYL 267

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KT++PYE VYSD QARFLSEYRFD++KLEPLVAKPHSPDNRALAREC+DVKI+RVYIG
Sbjct: 268 EDKTTLPYEPVYSDAQARFLSEYRFDISKLEPLVAKPHSPDNRALARECRDVKIDRVYIG 327

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDFMA AKVFLAS GKKVKVPTFLVPATQKVWMDVY+LPVPGSGGKTC+QIFE
Sbjct: 328 SCTGGKTEDFMAVAKVFLAS-GKKVKVPTFLVPATQKVWMDVYTLPVPGSGGKTCAQIFE 386

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 387 EAGCDTPASPSC 398

[4][TOP]
>UniRef100_A7QRJ3 Chromosome chr8 scaffold_150, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7QRJ3_VITVI
          Length = 424

 Score =  354 bits (908), Expect = 3e-96
 Identities = 175/192 (91%), Positives = 183/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P DS T+KYL
Sbjct: 208 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYL 267

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KT VPYE VYSD+QARFLSEYRFDV+KLEPLVAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 268 EDKTDVPYEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNRALARECKDVKIDRVYIG 327

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVF AS GKKVKVPTFLVPATQKVWMDVYSLPVPG GGKTCSQIFE
Sbjct: 328 SCTGGKTEDFLAAAKVFHAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGCGGKTCSQIFE 386

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 387 EAGCDTPASPSC 398

[5][TOP]
>UniRef100_C5XT62 Putative uncharacterized protein Sb04g002120 n=1 Tax=Sorghum
           bicolor RepID=C5XT62_SORBI
          Length = 507

 Score =  353 bits (905), Expect = 7e-96
 Identities = 172/192 (89%), Positives = 183/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMV+EAGGKNGV+P D  T+KYL
Sbjct: 253 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYL 312

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTSV YE VYSD QARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVK++RVYIG
Sbjct: 313 EGKTSVDYEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKVDRVYIG 372

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVFLAS GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE
Sbjct: 373 SCTGGKTEDFLAAAKVFLAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 431

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 432 EAGCDTPASPSC 443

[6][TOP]
>UniRef100_B9HKV5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9HKV5_POPTR
          Length = 443

 Score =  352 bits (904), Expect = 9e-96
 Identities = 171/192 (89%), Positives = 184/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+VAGATYKSMEF G+TVESL MEERMTLCNMV+EAGGKNGV+PPDS T+KYL
Sbjct: 189 ILQIIGEISVAGATYKSMEFAGTTVESLTMEERMTLCNMVIEAGGKNGVVPPDSTTFKYL 248

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KTS+PYE VYSD QARFL+EYRFDVTKLEPLVAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 249 EDKTSLPYEPVYSDAQARFLTEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIDRVYIG 308

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDFMAAAKVFLAS GKKV+VPTFLVPAT KVWMD+Y+LPVPGSGGKTCSQIFE
Sbjct: 309 SCTGGKTEDFMAAAKVFLAS-GKKVRVPTFLVPATGKVWMDLYTLPVPGSGGKTCSQIFE 367

Query: 543 EAGCDTPASPSC 578
           EAGCDTPA+P+C
Sbjct: 368 EAGCDTPANPTC 379

[7][TOP]
>UniRef100_Q6Z702 Os02g0125100 protein n=2 Tax=Oryza sativa RepID=Q6Z702_ORYSJ
          Length = 514

 Score =  350 bits (899), Expect = 3e-95
 Identities = 169/192 (88%), Positives = 183/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESLNMEERMTLCNMV+EAGGKNGV+P D  T+ YL
Sbjct: 260 ILQIIGEISVSGATYKSMEFVGSTVESLNMEERMTLCNMVIEAGGKNGVVPADQTTFNYL 319

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTSV YE VYSD QARF+S+YRFDV+KLEP++AKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 320 EGKTSVEYEPVYSDAQARFVSDYRFDVSKLEPVIAKPHSPDNRALARECKDVKIDRVYIG 379

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF AAAKVFLAS GKKVKVPTFLVPATQKVWMD+YS+PVPG+GGKTCSQIFE
Sbjct: 380 SCTGGKTEDFFAAAKVFLAS-GKKVKVPTFLVPATQKVWMDIYSIPVPGAGGKTCSQIFE 438

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 439 EAGCDTPASPSC 450

[8][TOP]
>UniRef100_C4JBG7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4JBG7_MAIZE
          Length = 505

 Score =  348 bits (892), Expect = 2e-94
 Identities = 169/192 (88%), Positives = 183/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P D  T+KYL
Sbjct: 251 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYL 310

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+TSV Y+ VYSD +ARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 311 EGRTSVDYQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIG 370

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVFLAS GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC+QIFE
Sbjct: 371 SCTGGKTEDFLAAAKVFLAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCAQIFE 429

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 430 EAGCDTPASPNC 441

[9][TOP]
>UniRef100_B6TYJ6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6TYJ6_MAIZE
          Length = 492

 Score =  348 bits (892), Expect = 2e-94
 Identities = 169/192 (88%), Positives = 183/192 (95%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P D  T+KYL
Sbjct: 251 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYL 310

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+TSV Y+ VYSD +ARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 311 EGRTSVDYQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIG 370

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVFLAS GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC+QIFE
Sbjct: 371 SCTGGKTEDFLAAAKVFLAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCAQIFE 429

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 430 EAGCDTPASPNC 441

[10][TOP]
>UniRef100_B4FG11 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B4FG11_MAIZE
          Length = 505

 Score =  348 bits (892), Expect = 2e-94
 Identities = 169/192 (88%), Positives = 182/192 (94%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMV+EAGGKNGV+P D  T+KYL
Sbjct: 251 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYL 310

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTSV YE VYSD QARF S+YRFDV+KLEP+VAKPHSPDNRA ARECKDVKI+RVYIG
Sbjct: 311 EGKTSVDYEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDVKIDRVYIG 370

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVFLAS GKKVKVPTFLVPATQKVW+D+YSLPVPGSGGKTCSQIFE
Sbjct: 371 SCTGGKTEDFLAAAKVFLAS-GKKVKVPTFLVPATQKVWLDIYSLPVPGSGGKTCSQIFE 429

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 430 EAGCDTPASPNC 441

[11][TOP]
>UniRef100_B6U6T6 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Zea mays
           RepID=B6U6T6_MAIZE
          Length = 504

 Score =  347 bits (890), Expect = 4e-94
 Identities = 169/192 (88%), Positives = 182/192 (94%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMV+EAGGKNGV+P D  T+KYL
Sbjct: 250 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVIEAGGKNGVVPADETTFKYL 309

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTSV YE VYSD QARF S+YRFDV+KLEP+VAKPHSPDNRA ARECKDVKI+RVYIG
Sbjct: 310 EGKTSVDYEPVYSDAQARFFSDYRFDVSKLEPVVAKPHSPDNRAPARECKDVKIDRVYIG 369

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAK+FLAS GKKVKVPTFLVPATQKVW+DVYSLPVPGSGGKTCSQIFE
Sbjct: 370 SCTGGKTEDFLAAAKLFLAS-GKKVKVPTFLVPATQKVWLDVYSLPVPGSGGKTCSQIFE 428

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 429 EAGCDTPASPNC 440

[12][TOP]
>UniRef100_C4IZQ5 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=C4IZQ5_MAIZE
          Length = 505

 Score =  346 bits (888), Expect = 6e-94
 Identities = 168/192 (87%), Positives = 182/192 (94%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVGSTVESL MEERMTLCNMVVEAGGKNGV+P D  T+KYL
Sbjct: 251 ILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADETTFKYL 310

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+TSV Y+ VYSD +ARF S+YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 311 EGRTSVDYQPVYSDAEARFFSDYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIG 370

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AA KVFLAS GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC+QIFE
Sbjct: 371 SCTGGKTEDFLAAVKVFLAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCAQIFE 429

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 430 EAGCDTPASPNC 441

[13][TOP]
>UniRef100_UPI0001983576 PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI0001983576
          Length = 508

 Score =  346 bits (887), Expect = 8e-94
 Identities = 169/192 (88%), Positives = 182/192 (94%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVG+TVESL MEERMTLCNMV+EAGGKNGV+P DS T+KYL
Sbjct: 254 ILQIIGEISVSGATYKSMEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYL 313

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KTS+PYE VYSD+QARFLSEYRFD++KLEPLVAKPHSPD  ALARECKDVKI+RVYIG
Sbjct: 314 EDKTSLPYEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDKCALARECKDVKIDRVYIG 373

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVF AS GKKVKVPTFLVPATQKVWMDVYSLPVPG GGKTCSQIFE
Sbjct: 374 SCTGGKTEDFLAAAKVFHAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGCGGKTCSQIFE 432

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 433 EAGCDTPASPTC 444

[14][TOP]
>UniRef100_A7NXJ3 Chromosome chr5 scaffold_2, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7NXJ3_VITVI
          Length = 507

 Score =  346 bits (887), Expect = 8e-94
 Identities = 169/192 (88%), Positives = 182/192 (94%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+V+GATYKSMEFVG+TVESL MEERMTLCNMV+EAGGKNGV+P DS T+KYL
Sbjct: 271 ILQIIGEISVSGATYKSMEFVGTTVESLTMEERMTLCNMVIEAGGKNGVVPADSTTHKYL 330

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E KTS+PYE VYSD+QARFLSEYRFD++KLEPLVAKPHSPD  ALARECKDVKI+RVYIG
Sbjct: 331 EDKTSLPYEPVYSDEQARFLSEYRFDISKLEPLVAKPHSPDKCALARECKDVKIDRVYIG 390

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAAKVF AS GKKVKVPTFLVPATQKVWMDVYSLPVPG GGKTCSQIFE
Sbjct: 391 SCTGGKTEDFLAAAKVFHAS-GKKVKVPTFLVPATQKVWMDVYSLPVPGCGGKTCSQIFE 449

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 450 EAGCDTPASPTC 461

[15][TOP]
>UniRef100_Q94AR8 3-isopropylmalate dehydratase n=1 Tax=Arabidopsis thaliana
           RepID=LEUC_ARATH
          Length = 509

 Score =  333 bits (855), Expect = 4e-90
 Identities = 160/192 (83%), Positives = 181/192 (94%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+VAGATYK+MEF G+T+ESL+MEERMTLCNMVVEAGGKNGVIPPD+ T  Y+
Sbjct: 255 ILQIIGEISVAGATYKTMEFSGTTIESLSMEERMTLCNMVVEAGGKNGVIPPDATTLNYV 314

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +TSVP+E VYSD  A F+++YRFDV+KLEP+VAKPHSPDNRALARECKDVKI+RVYIG
Sbjct: 315 ENRTSVPFEPVYSDGNASFVADYRFDVSKLEPVVAKPHSPDNRALARECKDVKIDRVYIG 374

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDFMAAAK+F A+ G+KVKVPTFLVPATQKVWMDVY+LPVPG+GGKTC+QIFE
Sbjct: 375 SCTGGKTEDFMAAAKLFHAA-GRKVKVPTFLVPATQKVWMDVYALPVPGAGGKTCAQIFE 433

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASPSC
Sbjct: 434 EAGCDTPASPSC 445

[16][TOP]
>UniRef100_B8LQ24 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQ24_PICSI
          Length = 516

 Score =  321 bits (823), Expect = 2e-86
 Identities = 152/192 (79%), Positives = 176/192 (91%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEITV+GATY++MEF GSTV+SL ME+RMTLCNMVVEAGGKNGV+  D +T+ YL
Sbjct: 263 ILQIIGEITVSGATYRAMEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVDADQITFDYL 322

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTS  +E++YSD+ AR+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +KI+RVYIG
Sbjct: 323 EGKTSSSFEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIG 382

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDFMAAAK+ + S G+KVKVPTFLVPATQKVWMD+Y+LPVPG  GKTCSQIFE
Sbjct: 383 SCTGGKTEDFMAAAKIMI-SAGQKVKVPTFLVPATQKVWMDLYTLPVPGGNGKTCSQIFE 441

Query: 543 EAGCDTPASPSC 578
           EAGCDTPA+P+C
Sbjct: 442 EAGCDTPANPNC 453

[17][TOP]
>UniRef100_B8LQY6 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=B8LQY6_PICSI
          Length = 515

 Score =  319 bits (817), Expect = 1e-85
 Identities = 152/192 (79%), Positives = 174/192 (90%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEITV+G TY++MEF GSTV+SL ME+RMTLCNMVVEAGGKNGV+  D  T+ YL
Sbjct: 262 ILQIIGEITVSGGTYRAMEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVAADQTTFDYL 321

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTS  +E++YSD+ AR+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +KI+RVYIG
Sbjct: 322 EGKTSSSFEALYSDEAARYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIG 381

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDFMAAAK+ L S G+KVKVPTFLVPATQKVWMD+Y+LPVPG  GKTC+QIFE
Sbjct: 382 SCTGGKTEDFMAAAKI-LISAGQKVKVPTFLVPATQKVWMDLYTLPVPGGNGKTCAQIFE 440

Query: 543 EAGCDTPASPSC 578
           EAGCDTPASP+C
Sbjct: 441 EAGCDTPASPNC 452

[18][TOP]
>UniRef100_A9TGU1 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9TGU1_PHYPA
          Length = 518

 Score =  315 bits (807), Expect = 2e-84
 Identities = 151/192 (78%), Positives = 174/192 (90%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+VAGATY++MEFVG+ V+++ ME+RMTLCNMVVEAGGKNGV+P D+ T KYL
Sbjct: 265 ILQIIGEISVAGATYRAMEFVGTAVDAMTMEDRMTLCNMVVEAGGKNGVVPADATTAKYL 324

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EGKTS PY+   SD  A FL EYRFDV+KLEPLVAKPHSPDNR LARECKDVKI+RVYIG
Sbjct: 325 EGKTSKPYQVFTSDGNASFLQEYRFDVSKLEPLVAKPHSPDNRGLARECKDVKIDRVYIG 384

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF+AAA++ LA  G+KVKVPTFLVPATQKVWMD+YSLPVPG+ GKTC++IF+
Sbjct: 385 SCTGGKTEDFLAAAEL-LAISGQKVKVPTFLVPATQKVWMDLYSLPVPGTDGKTCAEIFQ 443

Query: 543 EAGCDTPASPSC 578
           +AGCDTPASPSC
Sbjct: 444 QAGCDTPASPSC 455

[19][TOP]
>UniRef100_B9SQS6 3-isopropylmalate dehydratase, putative n=1 Tax=Ricinus communis
           RepID=B9SQS6_RICCO
          Length = 621

 Score =  308 bits (790), Expect = 1e-82
 Identities = 149/165 (90%), Positives = 157/165 (95%)
 Frame = +3

Query: 84  LNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQARFLSEYRFDV 263
           L MEERMTLCNMV+EAGGKNGVIP DS T+KYLE KTSVPYE VYSD+QARFLSEYRFD+
Sbjct: 394 LQMEERMTLCNMVIEAGGKNGVIPADSTTFKYLEDKTSVPYEPVYSDEQARFLSEYRFDI 453

Query: 264 TKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKV 443
           +KLEPLVAKPHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF AAAKVFLAS GKKVKV
Sbjct: 454 SKLEPLVAKPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFTAAAKVFLAS-GKKVKV 512

Query: 444 PTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTPASPSC 578
           PTFLVPATQKVWMDVYS+PVPGSGGKTCS+IFEEAGCDTPASP C
Sbjct: 513 PTFLVPATQKVWMDVYSIPVPGSGGKTCSRIFEEAGCDTPASPGC 557

[20][TOP]
>UniRef100_C0PRG9 Putative uncharacterized protein n=1 Tax=Picea sitchensis
           RepID=C0PRG9_PICSI
          Length = 237

 Score =  293 bits (750), Expect = 7e-78
 Identities = 139/175 (79%), Positives = 158/175 (90%)
 Frame = +3

Query: 54  MEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLEGKTSVPYESVYSDQQA 233
           MEF GSTV+SL ME+RMTLCNMVVEAGGKNGV+  D  T+ YLEGKTS  +E++YSD+ A
Sbjct: 1   MEFSGSTVKSLTMEDRMTLCNMVVEAGGKNGVVAADQTTFDYLEGKTSSSFEALYSDEAA 60

Query: 234 RFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVF 413
           R+L EYRFDV+KLEPLVAKPHSPDNRALAREC+ +KI+RVYIGSCTGGKTEDFMAAAK+ 
Sbjct: 61  RYLQEYRFDVSKLEPLVAKPHSPDNRALARECRHIKIDRVYIGSCTGGKTEDFMAAAKI- 119

Query: 414 LASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTPASPSC 578
           L S G+KVKVPTFLVPATQKVWMD+Y+LPVPG  GKTC+QIFEEAGCDTPASP+C
Sbjct: 120 LISAGQKVKVPTFLVPATQKVWMDLYTLPVPGGNGKTCAQIFEEAGCDTPASPNC 174

[21][TOP]
>UniRef100_A8JG03 Isopropylmalate dehydratase, large subunit n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8JG03_CHLRE
          Length = 487

 Score =  283 bits (723), Expect = 9e-75
 Identities = 132/192 (68%), Positives = 164/192 (85%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIGEI+VAGATYK+MEF GS +E +NM+ERMT+CNMVVEAGGKNGVI PD  T+ Y+
Sbjct: 234 ILQIIGEISVAGATYKAMEFAGSAIEGMNMDERMTICNMVVEAGGKNGVIAPDQTTFDYV 293

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +T   +E VYSD  A ++++Y++DV+KLEPLVA PHSPDNR  AREC DVKI+RVYIG
Sbjct: 294 KARTQEAFEPVYSDGAASYIADYKWDVSKLEPLVAAPHSPDNRKTARECSDVKIDRVYIG 353

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF++AAK+F  +  ++VKVPT+LVPATQKVW DVY++PVPG  GKT ++IFE
Sbjct: 354 SCTGGKTEDFISAAKLFYRA-KRQVKVPTYLVPATQKVWADVYTMPVPGCDGKTAAEIFE 412

Query: 543 EAGCDTPASPSC 578
           E+GC TPA+PSC
Sbjct: 413 ESGCITPAAPSC 424

[22][TOP]
>UniRef100_Q111B2 Homoaconitate hydratase family protein n=1 Tax=Trichodesmium
           erythraeum IMS101 RepID=Q111B2_TRIEI
          Length = 439

 Score =  251 bits (640), Expect = 4e-65
 Identities = 123/192 (64%), Positives = 153/192 (79%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQIIG+I+V+GATY++MEF G TV  + MEERMTLCNMV+EAGGKNGVI PD +T++YL
Sbjct: 191 ILQIIGDISVSGATYRTMEFAGETVGQMTMEERMTLCNMVIEAGGKNGVIAPDEMTFEYL 250

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+T  P+ES YSD+ A F S+  +DVTKLEP+VAKPHSPDN+ LAR C+DVKI+RVYIG
Sbjct: 251 RGRTDKPFESFYSDKNAEFYSDRSYDVTKLEPVVAKPHSPDNKELARNCQDVKIDRVYIG 310

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKT DF+ AAK+       +VKVPT+LVPATQKV+ D++ +      GKT S+IF 
Sbjct: 311 SCTGGKTSDFLHAAKLI---KDHQVKVPTYLVPATQKVYEDLFIIK---HDGKTLSEIFL 364

Query: 543 EAGCDTPASPSC 578
           +AGC  PA+PSC
Sbjct: 365 DAGCIEPAAPSC 376

[23][TOP]
>UniRef100_A5AN38 Putative uncharacterized protein n=1 Tax=Vitis vinifera
           RepID=A5AN38_VITVI
          Length = 252

 Score =  215 bits (547), Expect = 2e-54
 Identities = 117/160 (73%), Positives = 124/160 (77%), Gaps = 17/160 (10%)
 Frame = +3

Query: 150 IPPDSVTYKYLEGKTSVPYE--SVYSDQQARFLSEYRFDVTKLEPLVAK----------- 290
           +PP   +   LEGK   P+   S+  D   RFLSEYRFDV+KLEPLVAK           
Sbjct: 1   MPPSGAS---LEGKRR-PFTKASLRRDSVHRFLSEYRFDVSKLEPLVAKVRDFYMALSEI 56

Query: 291 ----PHSPDNRALARECKDVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV 458
               PHSPDNRALARECKDVKI+RVYIGSCTGGKTEDF+AAAKVF  SG KKVKVPTFLV
Sbjct: 57  IFIFPHSPDNRALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVFHVSG-KKVKVPTFLV 115

Query: 459 PATQKVWMDVYSLPVPGSGGKTCSQIFEEAGCDTPASPSC 578
           PATQKVWMDVYSLPVPG GGKTCSQIFEEAGCDTPASPSC
Sbjct: 116 PATQKVWMDVYSLPVPGCGGKTCSQIFEEAGCDTPASPSC 155

[24][TOP]
>UniRef100_C4C1N1 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Sebaldella termitidis
           ATCC 33386 RepID=C4C1N1_9FUSO
          Length = 435

 Score =  196 bits (498), Expect = 1e-48
 Identities = 95/192 (49%), Positives = 134/192 (69%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L++IG+I   GATYK M+F G  +   NMEERMT+CNM +EAGGK G+I PD +T +Y+
Sbjct: 184 VLKVIGDIGFDGATYKCMQFDGDAIHGFNMEERMTICNMAIEAGGKCGIIEPDEITVEYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             KT  P+E +YSD+ A + +EY+++  ++EP+VAKP +P N  LA+   DVK++R YIG
Sbjct: 244 TEKTDKPFELIYSDKDADYSAEYKYNANEMEPIVAKPFNPGNTDLAKNLGDVKLDRAYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKT DF+AAAK+     G+KV + TF+VP+T KV   +  + +    G+TC +IFE
Sbjct: 304 SCTGGKTTDFVAAAKIL---KGRKVAIETFIVPSTVKVEEALSKIII---DGETCMEIFE 357

Query: 543 EAGCDTPASPSC 578
           +AGC     PSC
Sbjct: 358 KAGCKI-GPPSC 368

[25][TOP]
>UniRef100_Q3APC5 3-isopropylmalate dehydratase n=1 Tax=Chlorobium chlorochromatii
           CaD3 RepID=Q3APC5_CHLCH
          Length = 431

 Score =  192 bits (487), Expect = 2e-47
 Identities = 103/192 (53%), Positives = 128/192 (66%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+IT  GATY++MEF G  + SL MEERMTL NM +EAGG NG+I  D++  +Y+
Sbjct: 184 ILQILGDITTDGATYRAMEFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADNIAEEYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +T  PYE   SD  A++ S YR++V  LEP+VA+PHSPDNRA  R     KI + YIG
Sbjct: 244 KARTKKPYEIFQSDPDAKYHSTYRYNVRDLEPVVAQPHSPDNRATVRSVAGTKITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DFM AAK+     G+KV V T +VPAT  V     SL      GK+  QIFE
Sbjct: 304 SCTGGKLSDFMMAAKIL---KGQKVTVTTTIVPATTLV---ARSLETEQYDGKSLKQIFE 357

Query: 543 EAGCDTPASPSC 578
           EAGC+  A PSC
Sbjct: 358 EAGCNV-ALPSC 368

[26][TOP]
>UniRef100_B4SDL0 Homoaconitate hydratase family protein n=1 Tax=Pelodictyon
           phaeoclathratiforme BU-1 RepID=B4SDL0_PELPB
          Length = 431

 Score =  191 bits (486), Expect = 3e-47
 Identities = 105/192 (54%), Positives = 128/192 (66%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+IT  GATY +MEF G  + SL MEERMTL NM +EAGG NG+I  DS+   Y+
Sbjct: 184 ILQILGDITTDGATYCAMEFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADSIAENYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + ++  PYE   SD  AR+ S+YR+DV  LEP+VA+PHSPDNRA  R  +  KI + YIG
Sbjct: 244 KARSQKPYELFQSDPDARYHSKYRYDVRTLEPVVAQPHSPDNRATVRSVQGTKITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DFM AAK+     G KV V T +VPAT KV  D   L      G++  QIFE
Sbjct: 304 SCTGGKLTDFMMAAKIL---KGHKVSVTTNIVPATVKVARD---LECELYDGQSLKQIFE 357

Query: 543 EAGCDTPASPSC 578
           +AGC T A PSC
Sbjct: 358 DAGC-TIALPSC 368

[27][TOP]
>UniRef100_A1BES2 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides DSM 266 RepID=A1BES2_CHLPD
          Length = 431

 Score =  191 bits (486), Expect = 3e-47
 Identities = 104/192 (54%), Positives = 126/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL I+G+I   GATY++MEF G  V SL +EERMTL NM +EAGG NG+I  D++T  Y+
Sbjct: 184 ILHILGDIGTDGATYRAMEFDGEAVFSLPIEERMTLTNMAIEAGGMNGIIAADAITEAYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T  PYE   SD  AR+ S Y ++V +LEP+VA PHSPDNRA  R  +   I R YIG
Sbjct: 244 NARTQKPYELFRSDPDARYHSSYTYNVRELEPVVACPHSPDNRATVRSVQGTAITRSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DFM AAK+     GKKV VPT +VPAT KV  D   L +    G+T  QIFE
Sbjct: 304 SCTGGKLSDFMMAAKIL---NGKKVSVPTNIVPATVKVAAD---LAIEQYEGRTLKQIFE 357

Query: 543 EAGCDTPASPSC 578
           +AGC   A PSC
Sbjct: 358 DAGCSI-ALPSC 368

[28][TOP]
>UniRef100_A4SFC8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeovibrioides DSM 265 RepID=A4SFC8_PROVI
          Length = 431

 Score =  187 bits (476), Expect = 4e-46
 Identities = 99/192 (51%), Positives = 126/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+I   GATY++MEF G  + SL MEERMTL NM +E GG NG+I  D +T  ++
Sbjct: 184 ILQILGDIGTDGATYRAMEFNGEAIHSLPMEERMTLTNMAIEGGGMNGIIAVDEITEAFV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + KTS PYE   SD  A + S+ R++ +++EP+VAKPHSPDNRA  +  K  KI + YIG
Sbjct: 244 KSKTSKPYEIFTSDPGAAYFSKTRYNASEMEPVVAKPHSPDNRATVQSMKGTKITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF  AAK+     GK+V VPT +VPAT KV    + L      GK+   IFE
Sbjct: 304 SCTGGKLADFKLAAKIL---SGKRVSVPTNIVPATVKV---AHDLETELYNGKSLKSIFE 357

Query: 543 EAGCDTPASPSC 578
           +AGC   A PSC
Sbjct: 358 DAGCSI-ALPSC 368

[29][TOP]
>UniRef100_Q8KER8 3-isopropylmalate dehydratase, large subunit, putative n=1
           Tax=Chlorobaculum tepidum RepID=Q8KER8_CHLTE
          Length = 431

 Score =  187 bits (474), Expect = 7e-46
 Identities = 102/192 (53%), Positives = 126/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+IT  GATY++MEF G  V SL ++ERMTLCNM +EAGG NG+I  D+VT  ++
Sbjct: 184 ILQILGDITTDGATYRAMEFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVTEAFV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +TS PYE   SD  A++ S YR++V K+EP+VAKPHSPDNRA         I + YIG
Sbjct: 244 KARTSKPYEIFTSDPDAQYHSMYRYNVEKMEPIVAKPHSPDNRATVHSVAGTPITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF  AAK+     GKKV V T +VPAT  V      L      G+T   IFE
Sbjct: 304 SCTGGKLTDFKLAAKIL---KGKKVAVTTNIVPATVLV---ASQLETEMYDGQTLRHIFE 357

Query: 543 EAGCDTPASPSC 578
           EAGC+  A PSC
Sbjct: 358 EAGCNI-ALPSC 368

[30][TOP]
>UniRef100_Q0YQD5 Homoaconitate hydratase family protein:3-isopropylmalate
           dehydratase, prokaryotic n=1 Tax=Chlorobium ferrooxidans
           DSM 13031 RepID=Q0YQD5_9CHLB
          Length = 431

 Score =  186 bits (473), Expect = 9e-46
 Identities = 102/192 (53%), Positives = 125/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+IT  GATYK+MEF G  + SL MEERMTL NM +EAGG NG+I  DSV   Y+
Sbjct: 184 ILQILGDITTDGATYKAMEFDGEAIFSLPMEERMTLTNMAIEAGGMNGIIAADSVAESYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             ++  PYE   SD  A++ S Y ++V +LEP+VA+PHSPDNRA  R  +  KI + YIG
Sbjct: 244 RARSQKPYEIFRSDPDAKYHSRYHYNVRELEPVVAQPHSPDNRATVRSVQGTKITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF+ AAK+     GKKV V T +VPAT  V     +L      G T  QIFE
Sbjct: 304 SCTGGKLTDFVMAAKIL---KGKKVSVTTNIVPATVLV---ARALETERFEGVTLKQIFE 357

Query: 543 EAGCDTPASPSC 578
           +AGC   A PSC
Sbjct: 358 DAGCSI-ALPSC 368

[31][TOP]
>UniRef100_B3EHN8 Homoaconitate hydratase family protein n=1 Tax=Chlorobium limicola
           DSM 245 RepID=B3EHN8_CHLL2
          Length = 431

 Score =  186 bits (472), Expect = 1e-45
 Identities = 102/192 (53%), Positives = 127/192 (66%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+I   GATY++MEF G  V SL ++ERMTLCNM +EAGG NG+I  D+VT  Y+
Sbjct: 184 ILQILGDIGTDGATYRAMEFDGEAVYSLPVDERMTLCNMAIEAGGMNGIIAADAVTEAYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +S PYE   SD  A + S YR++  +LEP+VAKPHSPDNRA  R  +  KI + YIG
Sbjct: 244 KAHSSKPYEIFQSDPDADYHSVYRYNARELEPVVAKPHSPDNRATVRSMQGTKITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DFM AAK+     GK+V VPT +VPAT  V     +L      G T  +IFE
Sbjct: 304 SCTGGKLTDFMLAAKIL---KGKQVTVPTNIVPATVLV---ARALECETWEGVTLKKIFE 357

Query: 543 EAGCDTPASPSC 578
           +AGC   A PSC
Sbjct: 358 DAGCSI-ALPSC 368

[32][TOP]
>UniRef100_B3QM97 Homoaconitate hydratase family protein n=1 Tax=Chlorobaculum parvum
           NCIB 8327 RepID=B3QM97_CHLP8
          Length = 431

 Score =  184 bits (467), Expect = 4e-45
 Identities = 102/192 (53%), Positives = 126/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+I   GATY++MEF G  V SL ++ERMTLCNM +EAGG NG+I  D+VT  ++
Sbjct: 184 ILQILGDIGTDGATYRAMEFDGEAVYSLPIDERMTLCNMAIEAGGMNGIIAADAVTEAFV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +TS PYE   SD  A++ S YR++V KLEP+VA+PHSPDNRA  R      I + YIG
Sbjct: 244 KARTSKPYEIFQSDPDAQYHSMYRYNVEKLEPVVAQPHSPDNRATVRSVAGTPITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF  AAK+     GKKV V T +VPAT  V      L      G+T   IFE
Sbjct: 304 SCTGGKITDFRLAAKIL---KGKKVAVTTNIVPATVLV---ASQLENEMYDGQTLRHIFE 357

Query: 543 EAGCDTPASPSC 578
           EAGC+  A PSC
Sbjct: 358 EAGCNI-ALPSC 368

[33][TOP]
>UniRef100_Q3B597 3-isopropylmalate dehydratase n=1 Tax=Chlorobium luteolum DSM 273
           RepID=Q3B597_PELLD
          Length = 431

 Score =  183 bits (465), Expect = 7e-45
 Identities = 99/192 (51%), Positives = 126/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+I   GATY+++EF G  + SL MEERMTL NM +EAGG NG+I  D +T  ++
Sbjct: 184 ILQILGDIGTDGATYRALEFDGDAIHSLPMEERMTLTNMAIEAGGMNGIIAVDEITEAFV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +T+  YE  +SD  A++ S YR+D +KLEP+VAKPHSPDNRA  R      I + YIG
Sbjct: 244 KARTTKSYEIFHSDPDAKYHSLYRYDASKLEPVVAKPHSPDNRATVRSVAGTPITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF  AA++     G+KV V T +VPAT +V  D   L      GKT  QIF 
Sbjct: 304 SCTGGKLTDFKMAARIL---NGRKVAVTTNIVPATVQVARD---LEQEMHEGKTLKQIFM 357

Query: 543 EAGCDTPASPSC 578
           EAGC+  A PSC
Sbjct: 358 EAGCNI-ALPSC 368

[34][TOP]
>UniRef100_C1ZRL8 Homoaconitate hydratase family protein/3-isopropylmalate
           dehydratase, large subunit n=1 Tax=Rhodothermus marinus
           DSM 4252 RepID=C1ZRL8_RHOMR
          Length = 432

 Score =  183 bits (464), Expect = 9e-45
 Identities = 93/184 (50%), Positives = 125/184 (67%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I + GATY++MEF G  V  L++EERMTL NM +EAGGK+G+I PD  T  Y+
Sbjct: 184 ILAIIGDIGIDGATYRAMEFDGEAVYDLSIEERMTLTNMAIEAGGKSGIIAPDEKTIAYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T  P+E  +SD  AR+ SEY +DV+KLEP+VAKPH PDNRA   E    K++R YIG
Sbjct: 244 RERTDAPFEIYHSDPDARYHSEYVYDVSKLEPVVAKPHRPDNRATVTEVAGTKLDRAYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK EDF+AAA++     G++V++ TF+VPA+  V   ++   +    G +   IF 
Sbjct: 304 SCTGGKLEDFIAAARIL---KGQEVRIDTFVVPASTYVEQQLHHYKI---DGVSLYDIFV 357

Query: 543 EAGC 554
            AGC
Sbjct: 358 NAGC 361

[35][TOP]
>UniRef100_B4S6N0 Homoaconitate hydratase family protein n=1 Tax=Prosthecochloris
           aestuarii DSM 271 RepID=B4S6N0_PROA2
          Length = 432

 Score =  180 bits (457), Expect = 6e-44
 Identities = 97/192 (50%), Positives = 127/192 (66%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+I   GATY++MEF GS V  L +EERMTL NM +EAGG NG+I  D VT  Y+
Sbjct: 184 ILQILGDIGTDGATYRAMEFDGSAVYQLPVEERMTLTNMAIEAGGMNGIIAADEVTEAYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +TS PYE  +SD  A + S Y ++V +LEP+VA+PHSPDNRA  R  +  +I + YIG
Sbjct: 244 KARTSKPYEIFHSDPDAIYHSIYHYNVEELEPVVAQPHSPDNRATVRSVQGTRITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF  AAK+     G++V + T +VPAT +V     SL      GK+  ++ E
Sbjct: 304 SCTGGKLSDFKMAAKIL---NGQQVSIQTNIVPATVEV---AKSLETEQYEGKSIRKVLE 357

Query: 543 EAGCDTPASPSC 578
           +AGC T A PSC
Sbjct: 358 DAGC-TIAQPSC 368

[36][TOP]
>UniRef100_B3QSN7 Homoaconitate hydratase family protein n=1 Tax=Chloroherpeton
           thalassium ATCC 35110 RepID=B3QSN7_CHLT3
          Length = 431

 Score =  179 bits (455), Expect = 1e-43
 Identities = 90/184 (48%), Positives = 122/184 (66%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+IT  GATY++MEF G  + SL ++ERMTL NM +EAGG +G+I  D +T  ++
Sbjct: 184 ILQILGDITTDGATYRAMEFAGEAIHSLPIDERMTLTNMAIEAGGMSGIIAADEITEAFV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +TS PYE  +SD  A++ S Y ++V +LEP+VAKPHSPDNR   R     K+ + Y+G
Sbjct: 244 KARTSAPYEIFHSDPDAKYFSTYHYNVEELEPVVAKPHSPDNRDTVRNVAGTKLTKCYLG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF  AAKV     G+ VKVPTF+VP +  V   +    +    G T  +IFE
Sbjct: 304 SCTGGKLTDFEFAAKVL---HGQTVKVPTFVVPGSTLVAKQLTEKTI---DGMTYMEIFE 357

Query: 543 EAGC 554
           +AGC
Sbjct: 358 KAGC 361

[37][TOP]
>UniRef100_UPI00016C35D3 homoaconitate hydratase family protein n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C35D3
          Length = 435

 Score =  178 bits (452), Expect = 2e-43
 Identities = 96/185 (51%), Positives = 124/185 (67%), Gaps = 2/185 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG+I V GATY++MEF G  V +LN+EERMTLCNM +EAGGKNG+I  D VT  Y+
Sbjct: 185 ILAVIGDIGVDGATYRAMEFDGDGVYALNIEERMTLCNMAIEAGGKNGIIAADQVTLDYV 244

Query: 183 EGKTSV--PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVY 356
             + +   PY  V SD  A+F+ E  +DV+KLEP++AKPHSPDN+A   + K  K++R Y
Sbjct: 245 NKRNAGNRPYTVVKSDPGAQFVFEKVYDVSKLEPVIAKPHSPDNKAFVSQVKGTKLDRAY 304

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           IGSCTGGK  DF AAA++     GK VK+ TF+VPAT +V      L     GG++   I
Sbjct: 305 IGSCTGGKLTDFKAAAQLL---NGKTVKIDTFVVPATTEV---ARGLDTETIGGRSLRDI 358

Query: 537 FEEAG 551
           F  AG
Sbjct: 359 FLSAG 363

[38][TOP]
>UniRef100_B3EKV4 Homoaconitate hydratase family protein n=1 Tax=Chlorobium
           phaeobacteroides BS1 RepID=B3EKV4_CHLPB
          Length = 432

 Score =  175 bits (443), Expect = 3e-42
 Identities = 99/192 (51%), Positives = 124/192 (64%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           ILQI+G+I+  GATY++MEF GS V SL MEERMTL NM +EAGG +G+I  DS+T  Y+
Sbjct: 184 ILQILGDISTDGATYRAMEFDGSAVFSLPMEERMTLTNMAIEAGGMSGIIAADSITEAYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + ++  PYE   SD  A + S +R+   +LEP+VA PHSPDNRA  R  +  KI + YIG
Sbjct: 244 KERSDKPYEIFTSDPDALYHSIHRYKTEELEPVVAMPHSPDNRATVRSVQGTKITKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF+ AAKV     G  V VPT +VPAT +V     SL      G+    I +
Sbjct: 304 SCTGGKLIDFVMAAKVL---KGNTVSVPTNIVPATVEV---AQSLTTEEFDGQPIITILK 357

Query: 543 EAGCDTPASPSC 578
           EAGC T A PSC
Sbjct: 358 EAGC-TIAPPSC 368

[39][TOP]
>UniRef100_B2VKF3 3-isopropylmalate dehydratase large subunit n=1 Tax=Erwinia
           tasmaniensis RepID=B2VKF3_ERWT9
          Length = 436

 Score =  169 bits (427), Expect = 2e-40
 Identities = 86/192 (44%), Positives = 126/192 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL ++  +TV GATY+++EF GS ++++++EERMT+CNMVVE G KNG++ P+  T  YL
Sbjct: 184 ILGLLARLTVDGATYEAIEFGGSVIDAMSVEERMTICNMVVECGAKNGIMVPNQATLDYL 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T +P+  V  D  AR+      +VT+++PLVAKPHSPDN       K+V I++ YIG
Sbjct: 244 ATRTDIPFSVVEPDADARYSQVLDINVTEMQPLVAKPHSPDNVVAIDTLKNVAISQAYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGK  DF+AAA+V     G+KV VPTF VPAT++V+  + S  +    G++  +I  
Sbjct: 304 SCTGGKLADFIAAARVI---KGRKVVVPTFAVPATKEVFHGLISTDI---DGQSVYRILC 357

Query: 543 EAGCDTPASPSC 578
           +AG    +   C
Sbjct: 358 DAGVQLSSESGC 369

[40][TOP]
>UniRef100_A6DRT0 3-isopropylmalate dehydratase n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DRT0_9BACT
          Length = 433

 Score =  161 bits (407), Expect = 4e-38
 Identities = 87/184 (47%), Positives = 116/184 (63%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IGEI  +GATY +MEF G  ++ L++EERMT+CNM +EAGGKNGVI  D+    Y+
Sbjct: 184 ILHMIGEIGFSGATYCAMEFEGPVIDELSIEERMTICNMAIEAGGKNGVIAADAKVEAYV 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +T VPY    +D  A +   Y  + ++LEP VA P +PD R    E     + R YIG
Sbjct: 244 KERTDVPYTLFKADADADYKDVYEINCSELEPTVAIPSAPDKRKGVSEIAGTDLTRAYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTGGKTEDF AAA++     G+KV + TF+VP+T  V  D+ +L       KT  +IF 
Sbjct: 304 SCTGGKTEDFAAAAEIMY---GQKVAMDTFVVPSTTFVEKDLNTLKFK---DKTYMEIFL 357

Query: 543 EAGC 554
           EAGC
Sbjct: 358 EAGC 361

[41][TOP]
>UniRef100_Q6B920 3-isopropylmalate dehydratase large subunit n=1 Tax=Gracilaria
           tenuistipitata var. liui RepID=Q6B920_GRATL
          Length = 439

 Score =  160 bits (406), Expect = 5e-38
 Identities = 80/193 (41%), Positives = 123/193 (63%), Gaps = 1/193 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL ++ ++T  GATY+S+EF G T++++++E+RMTLCNMV+EAG KNG+I P++ T +Y+
Sbjct: 188 ILLLLKDLTTQGATYQSIEFTGETIDNMSIEDRMTLCNMVIEAGAKNGIIIPNNSTIEYI 247

Query: 183 EGKTSV-PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
             ++ +  ++ +  DQ A +     +DVT ++P +AKPHSPDN       +  KI+R YI
Sbjct: 248 NARSDIKDFDIIVPDQSAHYTKVLEYDVTNIQPQIAKPHSPDNVDSIDNVEGEKIDRAYI 307

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIF 539
           GSCTGGK+ DF AAAK+       KV + TF VPAT++V+ D+ +  +      +  +I 
Sbjct: 308 GSCTGGKSSDFYAAAKIL---KNHKVSIDTFGVPATREVFYDIINQKIDDI---SVYEIL 361

Query: 540 EEAGCDTPASPSC 578
             AG      PSC
Sbjct: 362 VNAGVHMTTEPSC 374

[42][TOP]
>UniRef100_B3E0P6 3-isopropylmalate dehydratase large subunit n=1
           Tax=Methylacidiphilum infernorum V4 RepID=B3E0P6_METI4
          Length = 455

 Score =  149 bits (375), Expect = 2e-34
 Identities = 83/197 (42%), Positives = 113/197 (57%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTY--- 173
           IL IIGEI   GATY +M+F G  V +L +E+RMT+ NM +EAG KNG+ P D  T    
Sbjct: 202 ILHIIGEIGFDGATYMAMQFEGPGVSTLEIEDRMTVANMAIEAGAKNGIFPADQKTIDFV 261

Query: 174 --KYLEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
             K L+  T   +E V  D+   F + Y  D++ +EP VA PH+P NR  A+E   VKI+
Sbjct: 262 RQKVLKNGTKKEFEVVDPDKDQHFFASYFIDLSLVEPTVAAPHNPGNRMKAKELGSVKID 321

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           R Y+GSCTGGK  DF+A A +      + V V TF VP+T +V   ++ + +    GK+ 
Sbjct: 322 RAYLGSCTGGKLSDFIAFASIL---KNRTVSVETFAVPSTPEVVDQLHKIEIE---GKSI 375

Query: 528 SQIFEEAGCDTPASPSC 578
                EAG     +PSC
Sbjct: 376 WDTLREAGVQITENPSC 392

[43][TOP]
>UniRef100_C9RAX0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ammonifex
           degensii KC4 RepID=C9RAX0_9THEO
          Length = 421

 Score =  148 bits (373), Expect = 3e-34
 Identities = 85/194 (43%), Positives = 113/194 (58%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y +MEF G  +E L+M+ R T+CNM VEAG KNG+I PD  T  YL
Sbjct: 178 ILYTIGQIGVEGALYCAMEFTGPVIEELSMDGRFTMCNMAVEAGAKNGIIAPDEKTAAYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+   PY+   SD  AR+ + Y FDV++LEP VA PHSP N     E   + I++V IG
Sbjct: 238 EGRARRPYKFFQSDPDARYQAVYEFDVSRLEPQVALPHSPANTRPVTEVTHITIDQVVIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AA+V     GKKV   V   ++P TQ+++             +   +I
Sbjct: 298 SCTNGRLEDLRVAAQVL---KGKKVHPYVRLIVIPGTQEIYRQALR--------EGLIEI 346

Query: 537 FEEAGCDTPASPSC 578
           F EAG    ++P+C
Sbjct: 347 FLEAG-GAVSTPTC 359

[44][TOP]
>UniRef100_A4J182 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum reducens MI-1 RepID=A4J182_DESRM
          Length = 418

 Score =  147 bits (372), Expect = 4e-34
 Identities = 74/161 (45%), Positives = 102/161 (63%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YK+MEF G  +  L+M+ R T+CNM +EAGGKNG+I PD +T +Y+
Sbjct: 177 ILHTIGQIGVDGALYKAMEFCGEAISQLSMDGRFTMCNMAIEAGGKNGIIQPDEITRQYV 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+T  PY    SD  A++   Y FDV K+EP VA PH P+N     +   V I++  IG
Sbjct: 237 EGRTKRPYTFYTSDPDAQYSKVYEFDVNKIEPQVAFPHLPENARPVSQAGHVDIDQAVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA++     GKKV  +V   ++P TQ+++
Sbjct: 297 SCTNGRMEDLRLAAEIL---KGKKVHQQVRLIVIPGTQEIY 334

[45][TOP]
>UniRef100_C0Z3H8 AT4G13430 protein n=1 Tax=Arabidopsis thaliana RepID=C0Z3H8_ARATH
          Length = 175

 Score =  147 bits (370), Expect = 8e-34
 Identities = 69/78 (88%), Positives = 76/78 (97%)
 Frame = +3

Query: 345 NRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKT 524
           +RVYIGSCTGGKTEDFMAAAK+F A+G +KVKVPTFLVPATQKVWMDVY+LPVPG+GGKT
Sbjct: 35  DRVYIGSCTGGKTEDFMAAAKLFHAAG-RKVKVPTFLVPATQKVWMDVYALPVPGAGGKT 93

Query: 525 CSQIFEEAGCDTPASPSC 578
           C+QIFEEAGCDTPASPSC
Sbjct: 94  CAQIFEEAGCDTPASPSC 111

[46][TOP]
>UniRef100_B0TCR2 3-isopropylmalate dehydratase large subunit n=1 Tax=Heliobacterium
           modesticaldum Ice1 RepID=LEUC_HELMI
          Length = 420

 Score =  147 bits (370), Expect = 8e-34
 Identities = 76/161 (47%), Positives = 103/161 (63%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y+SMEF GS ++ L+M+ RMT+CNM +EAGGKNG+I PD  T  Y+
Sbjct: 179 ILHTIGDIGVDGALYQSMEFTGSAIDDLSMDGRMTMCNMAIEAGGKNGIIAPDKKTIAYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E + + PY+   SD  A++    ++DV KLEP+VA PH P+N     E   V+I++V IG
Sbjct: 239 EERATRPYKVYTSDPDAKYARVIKYDVEKLEPVVAFPHLPENTRPVSEAGHVEIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AAK+     GKKV   V   + P TQ ++
Sbjct: 299 SCTNGRIEDLRMAAKIL---QGKKVHKNVRCIIFPGTQAIY 336

[47][TOP]
>UniRef100_B3T8D2 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG5E24 RepID=B3T8D2_9ARCH
          Length = 423

 Score =  145 bits (367), Expect = 2e-33
 Identities = 77/192 (40%), Positives = 113/192 (58%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG+IT  G    +M+F G+ +  +++E R+TL NM  EAG KNG+I PD   + YL
Sbjct: 185 ILKIIGDITTEGGAGHAMQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYL 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y++VY D  A++   Y +DVT+LEPLVAKP SP N ++ +E   +++++ YIG
Sbjct: 245 SERGVTEYDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIG 304

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTG K ED  A AK+     GKKVK+ T ++PA   ++                +QIF 
Sbjct: 305 SCTGAKYEDLEAVAKIL---KGKKVKIRTEILPAAISIYKKATE--------NGLTQIFI 353

Query: 543 EAGCDTPASPSC 578
           +AG      P+C
Sbjct: 354 DAGA-VVGPPTC 364

[48][TOP]
>UniRef100_A5D4W1 3-isopropylmalate dehydratase large subunit n=1 Tax=Pelotomaculum
           thermopropionicum SI RepID=A5D4W1_PELTS
          Length = 420

 Score =  145 bits (366), Expect = 2e-33
 Identities = 75/162 (46%), Positives = 101/162 (62%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YK+MEF G  VE L+M+ R T+CNM VEAGGKNG+I PD  T  Y+
Sbjct: 179 ILHTIGDIGVDGALYKAMEFTGPAVEKLSMDGRFTMCNMAVEAGGKNGIIAPDETTRVYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+   PY    SD  A++   YR+D  ++EP VA PH P+N     E  +++I++V IG
Sbjct: 239 EGRCKRPYRFYRSDPDAKYEKIYRYDAAQIEPQVAFPHLPENSRPVSEAGNIEIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SCT G+ ED   AA+V     G+KV   V   + P T K+++
Sbjct: 299 SCTNGRMEDLREAARVL---KGRKVHKNVRLIIFPGTPKIYL 337

[49][TOP]
>UniRef100_B3TAM8 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8G2 RepID=B3TAM8_9ARCH
          Length = 423

 Score =  145 bits (366), Expect = 2e-33
 Identities = 77/192 (40%), Positives = 113/192 (58%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG+IT  G    +M+F G+ +  +++E R+TL NM  EAG KNG+I PD   + YL
Sbjct: 185 ILKIIGDITTEGGAGYAMQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYL 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y++VY D  A++   Y +DVT+LEPLVAKP SP N ++ +E   +++++ YIG
Sbjct: 245 SERGVTEYDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIG 304

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTG K ED  A AK+     GKKVK+ T ++PA   ++                +QIF 
Sbjct: 305 SCTGAKYEDLEAVAKIL---KGKKVKIRTEILPAAISIYKKATE--------NGLTQIFI 353

Query: 543 EAGCDTPASPSC 578
           +AG      P+C
Sbjct: 354 DAGA-VVGPPTC 364

[50][TOP]
>UniRef100_B3T9D1 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG6J21 RepID=B3T9D1_9ARCH
          Length = 423

 Score =  145 bits (366), Expect = 2e-33
 Identities = 77/192 (40%), Positives = 113/192 (58%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG+IT  G    +M+F G+ +  +++E R+TL NM  EAG KNG+I PD   + YL
Sbjct: 185 ILKIIGDITTEGGAGYAMQFGGNGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYL 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y++VY D  A++   Y +DVT+LEPLVAKP SP N ++ +E   +++++ YIG
Sbjct: 245 SERGVTEYDAVYDDDDAQYKKTYEYDVTELEPLVAKPFSPQNVSVVQETTGIELDKSYIG 304

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTG K ED  A AK+     GKKVK+ T ++PA   ++                +QIF 
Sbjct: 305 SCTGAKYEDLEAVAKIL---KGKKVKIRTEILPAAISIYKKATE--------NGLTQIFI 353

Query: 543 EAGCDTPASPSC 578
           +AG      P+C
Sbjct: 354 DAGA-VVGPPTC 364

[51][TOP]
>UniRef100_B4D0Q5 Aconitate hydratase domain protein n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D0Q5_9BACT
          Length = 456

 Score =  144 bits (364), Expect = 4e-33
 Identities = 85/197 (43%), Positives = 114/197 (57%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG+I   GATY++M++ G  V  ++M++RMT+ NM +EAGGKNG+ P D  T  Y+
Sbjct: 202 ILHVIGDIGFDGATYRAMQWEGPGVYGMSMDDRMTIANMAIEAGGKNGIFPFDEKTDAYV 261

Query: 183 -----EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
                E  T   +E    DQ  +F+ +  FD++KLEP VA    P  R  A+E   V ++
Sbjct: 262 KDRVQENGTKSTFEPAEIDQDQKFIYDKVFDLSKLEPTVACHPDPGQRKTAKELAGVSLD 321

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           R YIGSCTGGKT DF+A A+V     GK VK+ TF VPAT KV   V  L      G++ 
Sbjct: 322 RAYIGSCTGGKTSDFLAFARVV---KGKSVKIDTFGVPATTKV---VQELKDTQWDGQSV 375

Query: 528 SQIFEEAGCDTPASPSC 578
             I E AG     + SC
Sbjct: 376 WNILESAGVRMTENASC 392

[52][TOP]
>UniRef100_B3TBB7 Putative aconitase family (Aconitate hydratase) n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG8O8 RepID=B3TBB7_9ARCH
          Length = 423

 Score =  144 bits (363), Expect = 5e-33
 Identities = 70/159 (44%), Positives = 104/159 (65%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG+IT  G    +M+F G  +  +++E R+TL NM  EAG KNG+I PD   + YL
Sbjct: 185 ILKIIGDITTEGGAGCAMQFGGDGISDMSVESRLTLTNMTTEAGAKNGIIEPDQKVFDYL 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y++VY D+ A++   Y +DV++LEPLVAKP SP N ++ +E   ++I++ YIG
Sbjct: 245 AERGVTEYDAVYDDEDAQYAKTYEYDVSELEPLVAKPFSPQNVSVVQETTGIEIDKSYIG 304

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVW 479
           SCTG K ED +A A++     G+KVKV T +VPA   ++
Sbjct: 305 SCTGAKYEDLVAVARIL---KGRKVKVRTEVVPAAISIY 340

[53][TOP]
>UniRef100_Q8PZT3 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina mazei RepID=LEUC1_METMA
          Length = 391

 Score =  143 bits (361), Expect = 8e-33
 Identities = 68/155 (43%), Positives = 98/155 (63%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L +IG+  +AGATYK++EF G  +  L++  RMTLCNM +E G K G++PPD  T+ +L+
Sbjct: 155 LYLIGKTGIAGATYKAVEFYGQAISELSVAGRMTLCNMAIEMGAKTGIVPPDEKTFDFLK 214

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
            +   PYE VYSD  A +L E+ +D   +EP VA PH  DN     E +   +++V+IG+
Sbjct: 215 NRAVAPYEPVYSDPDASYLKEFVYDAGDIEPQVACPHQVDNVKPVGEVEGTHVDQVFIGT 274

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQ 470
           CT G+ ED   AA V     GKKV V T ++PA++
Sbjct: 275 CTNGRLEDLEVAASVL---KGKKVTVRTIIIPASR 306

[54][TOP]
>UniRef100_B9XBH0 Aconitate hydratase domain protein n=1 Tax=bacterium Ellin514
           RepID=B9XBH0_9BACT
          Length = 455

 Score =  143 bits (360), Expect = 1e-32
 Identities = 85/197 (43%), Positives = 117/197 (59%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IGEI   GATY++M+F GS V SL+M++RMT+ NM +EAGGKNG+   D+ T  ++
Sbjct: 202 ILHCIGEIGFDGATYRAMQFDGSGVASLSMDDRMTIANMAIEAGGKNGIFEFDAQTKAFV 261

Query: 183 EGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           + +     T   Y+ V  D   +F+ +   D++KLEP VA    P  R  A+E  DVK++
Sbjct: 262 DYRCKLNGTKATYQPVERDANEKFVYDMVVDLSKLEPTVACHPDPGQRKKAKE-MDVKLD 320

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           R YIGSCTGGKT DF+  A+V     GK+V + TF VPAT ++   V+ L     G KT 
Sbjct: 321 RAYIGSCTGGKTSDFLEFARVL---KGKRVMIDTFGVPATPEI---VHDLQTARWGEKTV 374

Query: 528 SQIFEEAGCDTPASPSC 578
            QI  +AG     +  C
Sbjct: 375 WQILVDAGVQMTENAGC 391

[55][TOP]
>UniRef100_UPI0001966B48 hypothetical protein SUBVAR_01587 n=1 Tax=Subdoligranulum variabile
           DSM 15176 RepID=UPI0001966B48
          Length = 419

 Score =  142 bits (359), Expect = 1e-32
 Identities = 77/194 (39%), Positives = 116/194 (59%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IGEI V+GA YKS+EF G  V+SL ME+R+ +CNM +EAG KNG+ P D +   YL
Sbjct: 179 ILHLIGEIGVSGALYKSLEFTGDGVKSLTMEDRLCICNMAIEAGAKNGIFPVDEICEAYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G++  P+    +D  A +      D+  LEP V+ PH P+N  LA+E KD+KI+++ IG
Sbjct: 239 KGRSQRPWVKYEADPDAEYERTVIIDLDTLEPTVSYPHLPENTHLAKEGKDIKIDQIVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED  AA ++     GK +   V   ++PAT  V+ +           +  ++ 
Sbjct: 299 SCTNGRIEDMQAAYEIL---KGKHIAKGVRGIIIPATMAVYKECIL--------RGYTEA 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FIDAGC-IVSTPTC 360

[56][TOP]
>UniRef100_UPI00019E5A8A 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=UPI00019E5A8A
          Length = 310

 Score =  142 bits (358), Expect = 2e-32
 Identities = 72/161 (44%), Positives = 103/161 (63%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YK+MEF G  +E L+M+ R+T+ NM +EAGGKNG++ PD +T  Y+
Sbjct: 69  ILHIIGDIGVDGALYKAMEFAGPAIEKLSMDGRLTMANMAIEAGGKNGIVAPDEITRAYV 128

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+   PY    SD  A +    R+D +K+EPLVA PH P+N     +   V++++V IG
Sbjct: 129 EGRVKKPYTFYKSDADAVYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGLVELDQVVIG 188

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA V     GKKV  ++   ++P TQ+++
Sbjct: 189 SCTNGRMEDLRLAAGVL---KGKKVSDRIRLIVIPGTQQIY 226

[57][TOP]
>UniRef100_C8W661 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfotomaculum acetoxidans DSM 771
           RepID=C8W661_9FIRM
          Length = 420

 Score =  142 bits (358), Expect = 2e-32
 Identities = 72/161 (44%), Positives = 103/161 (63%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YK+MEF G  +E L+M+ R+T+ NM +EAGGKNG++ PD +T  Y+
Sbjct: 179 ILHIIGDIGVDGALYKAMEFAGPAIEKLSMDGRLTMANMAIEAGGKNGIVAPDEITRAYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           EG+   PY    SD  A +    R+D +K+EPLVA PH P+N     +   V++++V IG
Sbjct: 239 EGRVKKPYTFYKSDADAVYSDIRRYDASKIEPLVAFPHLPENTRPVSQAGLVELDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA V     GKKV  ++   ++P TQ+++
Sbjct: 299 SCTNGRMEDLRLAAGVL---KGKKVSDRIRLIVIPGTQQIY 336

[58][TOP]
>UniRef100_C7GFH7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Roseburia
           intestinalis L1-82 RepID=C7GFH7_9FIRM
          Length = 420

 Score =  142 bits (358), Expect = 2e-32
 Identities = 72/163 (44%), Positives = 103/163 (63%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D++  +Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGISFLSMDDRFTIANMAIEAGGKNGIFPVDNLAKEYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E  +  PY    +D+ A +   Y  D++ L+P VA PH P+N     E  D+KI++V IG
Sbjct: 239 EAHSKRPYVVYEADEDAEYEETYTIDLSTLKPTVAFPHLPENTKTIDEVGDIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           SCT G+ +D   AA +     GKKV   +   ++PATQK+++D
Sbjct: 299 SCTNGRMDDLRVAASIL---KGKKVAKGLRVIVIPATQKIYLD 338

[59][TOP]
>UniRef100_C0FYL9 Putative uncharacterized protein n=1 Tax=Roseburia inulinivorans
           DSM 16841 RepID=C0FYL9_9FIRM
          Length = 436

 Score =  142 bits (358), Expect = 2e-32
 Identities = 74/162 (45%), Positives = 103/162 (63%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +  L M++R T+ NM +EAGGKNG+ P D +  +Y+
Sbjct: 195 ILHIIGMIGVDGALYKSMEFVGDGIRYLTMDDRFTIANMAIEAGGKNGIFPVDDLAKQYM 254

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E  +  PY    +D+ A + +EY  D++ L+P V+ PH P+N     E  DVKI++V IG
Sbjct: 255 EEHSKRPYVVYEADEDAEYDAEYTIDLSTLKPTVSFPHLPENTRTIDEVGDVKIDQVVIG 314

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+ +D   AA V     GKKVK  +   ++PATQK+++
Sbjct: 315 SCTNGRMDDLRIAASVL---KGKKVKKGLRVIVIPATQKIYL 353

[60][TOP]
>UniRef100_A6TTR7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Alkaliphilus
           metalliredigens QYMF RepID=A6TTR7_ALKMQ
          Length = 420

 Score =  142 bits (357), Expect = 2e-32
 Identities = 76/163 (46%), Positives = 102/163 (62%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  ++ L M++R T+ NM +EAGGKNG+ P D +T +Y+
Sbjct: 179 ILHIIGTIGVDGALYKSMEFVGEGIKHLTMDDRFTMANMAIEAGGKNGIFPVDELTLEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
              +  PY    +D+ A +   Y  D+++L P VA PH PDN     E  DVKI++V IG
Sbjct: 239 RVHSKRPYTVYRADEDAVYEETYEIDLSRLLPTVAFPHIPDNIRTIDEVGDVKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           SCT G+ +D   AAKV     GK+V   V   + PATQK+++D
Sbjct: 299 SCTNGRIQDLRMAAKVM---EGKQVAKGVRVIVFPATQKIYLD 338

[61][TOP]
>UniRef100_B8E2X0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           turgidum DSM 6724 RepID=B8E2X0_DICTD
          Length = 424

 Score =  141 bits (356), Expect = 3e-32
 Identities = 82/196 (41%), Positives = 114/196 (58%), Gaps = 4/196 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YK+MEF G  + +L+M +R+T+CNM +EAG KNG+I PD +T +Y+
Sbjct: 179 ILYTIGQIGVDGARYKAMEFTGEVIRNLSMSDRLTICNMAIEAGAKNGIIEPDEITLEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYI 359
             +    ++   SD+ A +   Y +DVT LEP+VA PH P N + ++   KD+ I++VYI
Sbjct: 239 RNRAKRNFKVYKSDEDAHYKEIYEWDVTNLEPIVAFPHLPSNIKKISDIGKDIYIDQVYI 298

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AAK+     G KV   V   + PAT  V+M            +   +
Sbjct: 299 GSCTNGRIEDLRLAAKIL---KGHKVHKDVRLIVTPATPNVYMQALK--------EGLIE 347

Query: 534 IFEEAGCD-TPASPSC 578
           IF E G   TP  PSC
Sbjct: 348 IFLEVGASITP--PSC 361

[62][TOP]
>UniRef100_B5YEF5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Dictyoglomus
           thermophilum H-6-12 RepID=B5YEF5_DICT6
          Length = 424

 Score =  141 bits (355), Expect = 4e-32
 Identities = 81/196 (41%), Positives = 113/196 (57%), Gaps = 4/196 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG I V GA YK+MEF G  + +L M +R+T+CNM +EAG KNG+I PD +T  Y+
Sbjct: 179 ILYTIGNIGVDGARYKAMEFTGEVIRNLPMSDRLTICNMAIEAGAKNGIIEPDEITLDYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYI 359
             +    ++   SD+ A++   Y +DV+ LEP+VA PH P N + ++   KD+ I++VYI
Sbjct: 239 RNRAKRDFKIYKSDEDAQYKEVYEWDVSDLEPIVAFPHLPSNIKKISEISKDIYIDQVYI 298

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AAK+     G KV   V   + PAT  ++M            +   +
Sbjct: 299 GSCTNGRIEDLRIAAKIL---KGHKVHKDVRLIITPATPNIYMQALK--------EGLIE 347

Query: 534 IFEEAGCD-TPASPSC 578
           IF EAG   TP  PSC
Sbjct: 348 IFLEAGASITP--PSC 361

[63][TOP]
>UniRef100_Q12TV2 Homoaconitase large subunit n=1 Tax=Methanococcoides burtonii DSM
           6242 RepID=Q12TV2_METBU
          Length = 413

 Score =  140 bits (353), Expect = 7e-32
 Identities = 65/160 (40%), Positives = 102/160 (63%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L++IG +  +GATYK+ EF G T+  L++  RMTL NM +E G K G++PPD  T+ +LE
Sbjct: 177 LKVIGTVGASGATYKAAEFYGDTITDLSISGRMTLSNMAIEMGAKAGIVPPDQKTFDFLE 236

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
           G+    YE VY+D+ A + +EY  D   LEP +A PH  DN     E +  K+++V+IG+
Sbjct: 237 GRAVEGYEPVYADEDAEYCAEYDIDGANLEPQIALPHQVDNVCDVSEIEGKKVDQVFIGT 296

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           CT G+ ED   AA++     G++V V T ++PA++ + ++
Sbjct: 297 CTNGRLEDLEVAAEIL---KGEQVAVRTIVIPASRSIMLE 333

[64][TOP]
>UniRef100_C4ZBK5 3-isopropylmalate dehydratase, large subunit n=1 Tax=Eubacterium
           rectale ATCC 33656 RepID=C4ZBK5_EUBR3
          Length = 420

 Score =  139 bits (351), Expect = 1e-31
 Identities = 72/162 (44%), Positives = 103/162 (63%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D +T +Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGLKYLSMDDRFTIANMAIEAGGKNGIFPVDDLTREYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +  P+    +D  A +  EY  D++ L+  V+ PH PDN     E  DVKI++V IG
Sbjct: 239 KEHSKRPFTEYEADSDAEYDEEYTIDLSTLKSTVSFPHLPDNTRTIDEVGDVKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+ +D   AAK+     GKKV   +   ++PATQK+++
Sbjct: 299 SCTNGRMDDLRIAAKIL---EGKKVADGIRVIVIPATQKIYL 337

[65][TOP]
>UniRef100_B5ICW8 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5ICW8_9EURY
          Length = 419

 Score =  139 bits (351), Expect = 1e-31
 Identities = 76/165 (46%), Positives = 104/165 (63%), Gaps = 5/165 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I   GATYKSMEF G T++ ++ME R T+ NM +EAGGK G+I PD+ T KYL
Sbjct: 175 ILHIIGTIGADGATYKSMEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYL 234

Query: 183 EGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK--DVKINRV 353
           E       Y  + SD  A F  EY F+V +LEP V+ PH+ DN     E K  +++I++V
Sbjct: 235 EEMGRGEKYREIKSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKMNIRIDQV 294

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           YIG+CT G+ ED   AAK+     G KV  K    ++PA+++V++
Sbjct: 295 YIGTCTNGRIEDLRVAAKIL---DGNKVNKKTRLIVIPASRRVYI 336

[66][TOP]
>UniRef100_B5IBC4 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IBC4_9EURY
          Length = 419

 Score =  139 bits (350), Expect = 2e-31
 Identities = 76/165 (46%), Positives = 104/165 (63%), Gaps = 5/165 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I   GATYKSMEF G T++ ++ME R T+ NM +EAGGK G+I PD+ T KYL
Sbjct: 175 ILHIIGTIGADGATYKSMEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYL 234

Query: 183 EGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK--DVKINRV 353
           E       Y  + SD  A F  EY F+V +LEP V+ PH+ DN     E K  +++I++V
Sbjct: 235 EEMGRGDKYREIKSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKMNIRIDQV 294

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           YIG+CT G+ ED   AAK+     G KV  K    ++PA+++V++
Sbjct: 295 YIGTCTNGRIEDLRVAAKIL---DGNKVNKKTRLIVIPASRRVYI 336

[67][TOP]
>UniRef100_Q8TLF1 3-isopropylmalate dehydratase large subunit 1 n=1
           Tax=Methanosarcina acetivorans RepID=LEUC1_METAC
          Length = 424

 Score =  139 bits (349), Expect = 2e-31
 Identities = 65/155 (41%), Positives = 98/155 (63%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L +IG+  +AGATYK++EF G  +  L +  RMTLCNM +E G K G++PPD  T+++L+
Sbjct: 188 LYLIGKTGIAGATYKAVEFYGQAIRELTVAGRMTLCNMAIEMGAKTGIVPPDEKTFEFLK 247

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
            + +  YE VY+D  A +L E+ +D   +EP VA PH  DN     E +   +++V+IG+
Sbjct: 248 NRAAATYEPVYADPDAVYLEEFTYDADDIEPQVACPHQVDNVKPVGEVEGTHVDQVFIGT 307

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQ 470
           CT G+ ED   AA V     GK+V V T ++PA++
Sbjct: 308 CTNGRLEDLEVAAAVL---KGKQVAVRTIVIPASR 339

[68][TOP]
>UniRef100_O67078 3-isopropylmalate dehydratase large subunit n=1 Tax=Aquifex
           aeolicus RepID=LEUC_AQUAE
          Length = 432

 Score =  138 bits (347), Expect = 3e-31
 Identities = 76/188 (40%), Positives = 112/188 (59%), Gaps = 4/188 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y++MEF G T+ +L+ME+R T+ NM +EAGGK+G+I PD  T +Y+
Sbjct: 178 ILYTIGQIGVDGALYRAMEFDGETIRNLSMEQRFTIANMAIEAGGKSGIISPDEKTIEYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +   P++   SD  A + S Y +D +++EPLVA P+ P N     E   + I++ +IG
Sbjct: 238 KQRAKRPWKVYQSDPDAEYHSVYEWDASQIEPLVAWPYLPSNVHPVSESTHITIDQAFIG 297

Query: 363 SCTGGKTEDFMAAAKVFLAS--GGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCS 530
           SCT G+ ED   AAKVF A+   GKKV   V   ++PA++ ++             +   
Sbjct: 298 SCTNGRIEDLRVAAKVFEAALKQGKKVHPYVRCIVIPASKAIYKQALK--------EGLI 349

Query: 531 QIFEEAGC 554
            IF EAGC
Sbjct: 350 DIFMEAGC 357

[69][TOP]
>UniRef100_C0EDN6 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EDN6_9CLOT
          Length = 421

 Score =  137 bits (345), Expect = 6e-31
 Identities = 77/194 (39%), Positives = 114/194 (58%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  +++L M++R+ + NM +EAGGKNG+   D VT  Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFGGEGLKNLTMDDRLCMANMAIEAGGKNGIFEVDEVTIAYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + K + PY +   D  A + + Y  D+++++  V+ PH PDN     E  DVKI++V IG
Sbjct: 239 KDKVNRPYTAYAPDPDAEYDAVYDIDLSQIKSTVSFPHLPDNTRTIDEVGDVKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AAK+     GK+V   V   ++PATQK++++   L           + 
Sbjct: 299 SCTNGRLSDIAVAAKIL---EGKQVAKHVRAIVIPATQKIYLEALKLGY--------LET 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FVKAGC-VVSTPTC 360

[70][TOP]
>UniRef100_C4FRW1 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC
           17748 RepID=C4FRW1_9FIRM
          Length = 419

 Score =  137 bits (344), Expect = 8e-31
 Identities = 79/195 (40%), Positives = 117/195 (60%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG+I V GA Y ++EF G  V+ + M +R+T+CNM +EAGGK GV P D+VT +Y+
Sbjct: 178 ILDLIGQIGVDGARYMALEFAGDGVQHMTMADRLTICNMAIEAGGKCGVFPYDAVTEEYI 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYI 359
           +G+ + P E +  D  A +      D++KL+P+VA PH P N     E  KD+KI++V I
Sbjct: 238 KGRVNRPVEPIAPDADAVYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKDIKIDQVII 297

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED +AAA++F    G+KV   V   ++P +Q    DVY   +          
Sbjct: 298 GSCTNGRYEDLVAAAEIF---KGRKVAPFVRCIVIPGSQ----DVYDQAMKDG----LLD 346

Query: 534 IFEEAGCDTPASPSC 578
           IF +A C   ++P+C
Sbjct: 347 IFIQADC-AVSTPTC 360

[71][TOP]
>UniRef100_A8UWH6 3-isopropylmalate dehydratase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1
           RepID=A8UWH6_9AQUI
          Length = 432

 Score =  137 bits (344), Expect = 8e-31
 Identities = 76/193 (39%), Positives = 112/193 (58%), Gaps = 4/193 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IGEI V GA Y++MEF G  +  L++E+R+T+ NM +EAGGK+G+I PD  T +Y+
Sbjct: 178 ILHTIGEIGVDGALYRAMEFEGEAIRELSVEQRLTITNMAIEAGGKSGIIAPDDKTIEYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +    ++   SD  A + S Y +D +K+EPLVA P+ P N     E   + +++ +IG
Sbjct: 238 KERAQKEWKVYESDPDAEYHSVYEWDASKIEPLVAWPYLPSNVHPVSESTHINVDQAFIG 297

Query: 363 SCTGGKTEDFMAAAKVFLAS--GGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCS 530
           SCT G+ ED   AAKVF ++   GKKV   V   ++PA++ V+M            +   
Sbjct: 298 SCTNGRIEDLRIAAKVFESALKQGKKVHPYVRCIVIPASKNVYMQAMK--------EGLI 349

Query: 531 QIFEEAGCDTPAS 569
            IF EAGC    S
Sbjct: 350 DIFMEAGCAVSTS 362

[72][TOP]
>UniRef100_B8CX22 3-isopropylmalate dehydratase large subunit n=1 Tax=Halothermothrix
           orenii H 168 RepID=LEUC_HALOH
          Length = 420

 Score =  137 bits (344), Expect = 8e-31
 Identities = 77/192 (40%), Positives = 108/192 (56%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y++MEF G T+E+L+M+ RMT+ NM +EAGGK G+I PD  T+KYL
Sbjct: 179 ILYTIGDIGVDGALYRAMEFTGETIENLSMDNRMTISNMAIEAGGKCGLIAPDEKTFKYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +    Y   YSD  A +     +DV+ +EP VA PH P+N     E  D+KI++  IG
Sbjct: 239 ENRAQRDYTPCYSDDDAEYEKVIEYDVSDIEPQVAFPHLPENTRPISEEGDIKIDQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCT G+ ED   AA + L        V   ++P TQ ++             +   +IF 
Sbjct: 299 SCTNGRMEDLRIAAGI-LKEKQVHHDVRCIVIPGTQDIYKQALK--------EGLIEIFI 349

Query: 543 EAGCDTPASPSC 578
           EAG    ++P+C
Sbjct: 350 EAGA-AVSTPTC 360

[73][TOP]
>UniRef100_C0V4R3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Veillonella
           parvula DSM 2008 RepID=C0V4R3_9FIRM
          Length = 419

 Score =  136 bits (343), Expect = 1e-30
 Identities = 78/195 (40%), Positives = 117/195 (60%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG+I V GA Y ++EF G  V+ + M +R+T+CNM +EAGGK GV P D++T +Y+
Sbjct: 178 ILDLIGQIGVDGARYMALEFAGEGVQHMTMADRLTICNMAIEAGGKCGVFPYDAITEEYI 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYI 359
           +G+ + P E +  D  A +      D++KL+P+VA PH P N     E  KD+KI++V I
Sbjct: 238 KGRVNRPVEPIAPDADAVYAQTITIDLSKLQPVVAFPHLPSNTHYINEIDKDIKIDQVII 297

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED +AAA++F    G+KV   V   ++P +Q    DVY   +          
Sbjct: 298 GSCTNGRYEDLVAAAEIF---KGRKVAPFVRCIVIPGSQ----DVYDQAMKDG----LLD 346

Query: 534 IFEEAGCDTPASPSC 578
           IF +A C   ++P+C
Sbjct: 347 IFIQADC-AVSTPTC 360

[74][TOP]
>UniRef100_Q24XT4 3-isopropylmalate dehydratase large subunit n=2
           Tax=Desulfitobacterium hafniense RepID=LEUC_DESHY
          Length = 421

 Score =  136 bits (342), Expect = 1e-30
 Identities = 70/161 (43%), Positives = 100/161 (62%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y+SMEF G  + +L+M+ R+T+CNM VEAG KNG+IPPD  T  Y+
Sbjct: 180 ILYTIGKIGVDGARYRSMEFTGEGIAALSMDGRLTMCNMAVEAGAKNGIIPPDEKTLAYV 239

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +   PY+  +SD  A+++  Y +DV  +   VA PH P+N     E K +KI++V IG
Sbjct: 240 NERAKRPYKVYHSDPDAQYVEVYEWDVADIPLQVAFPHLPENAKPVSEGKGIKIDQVVIG 299

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA++     G+KV   V   ++P TQ ++
Sbjct: 300 SCTNGRLEDMQVAAQIL---KGQKVHGDVRLIVIPGTQDIY 337

[75][TOP]
>UniRef100_A9A5B7 3-isopropylmalate dehydratase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A5B7_NITMS
          Length = 422

 Score =  136 bits (342), Expect = 1e-30
 Identities = 65/159 (40%), Positives = 102/159 (64%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG+I   G  Y++M+F G+ ++ +++E R+TLCNM  EAG KNG+   D     YL
Sbjct: 184 ILKIIGDIGTDGGNYRTMQFGGTGIDEMSVESRLTLCNMTTEAGAKNGIAEADQKVVDYL 243

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             + +   +    D  A++ + Y ++ +++EPLVAKP SP+N A+ RE   V++++ YIG
Sbjct: 244 SSRGATNAQVFKGDDDAQYANVYEYEASEMEPLVAKPFSPENIAVVREAPSVELDKSYIG 303

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVW 479
           SCTG K ED  AAAK+     GK VK+ T ++PA+  ++
Sbjct: 304 SCTGAKYEDLEAAAKIL---KGKTVKIRTEILPASISIY 339

[76][TOP]
>UniRef100_Q46B45 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosarcina
           barkeri str. Fusaro RepID=Q46B45_METBF
          Length = 413

 Score =  135 bits (341), Expect = 2e-30
 Identities = 64/155 (41%), Positives = 97/155 (62%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L +IG+  + GATYK++EF G  +  L++  RMTLCNM +E G K G++PPD  T+ +L+
Sbjct: 177 LYLIGKTGIDGATYKAVEFYGQAISELSVSGRMTLCNMAIEMGAKTGIVPPDEKTFAFLK 236

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
            + + PY+ VY+DQ A ++ E  +    +EP VA PH  DN     E +   I++V+IG+
Sbjct: 237 NRAAAPYDPVYADQDAVYVKEPVYSAEDIEPQVACPHQVDNVKPVGEVEGTHIDQVFIGT 296

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQ 470
           CT G+ ED   AA +     GKKV V T ++PA++
Sbjct: 297 CTNGRLEDLEVAAAIL---KGKKVAVRTIVIPASR 328

[77][TOP]
>UniRef100_B5YKE0 3-isopropylmalate dehydratase large subunit n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=LEUC_THEYD
          Length = 421

 Score =  135 bits (341), Expect = 2e-30
 Identities = 68/162 (41%), Positives = 103/162 (63%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA+Y +MEF+G  ++++ M  R ++CNM +EAG K G+I PD +T +Y+
Sbjct: 179 ILYTIGDIGVDGASYMAMEFIGEVIDNMPMSGRFSMCNMAIEAGAKAGIIVPDKITEEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +   PY+   SDQ A++     +D +++ P+VA PH P N   A E   +KI++V IG
Sbjct: 239 KLRAKRPYKIYNSDQDAKYFEIKEYDCSRIPPVVACPHLPSNVKPANELSHIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SCT G+ ED   AA V     G+KV  +V   ++PATQK++M
Sbjct: 299 SCTNGRLEDLREAAMVL---KGRKVHPEVRMIIIPATQKIYM 337

[78][TOP]
>UniRef100_C8WM14 3-isopropylmalate dehydratase, large subunit n=2 Tax=Eggerthella
           lenta DSM 2243 RepID=C8WM14_9ACTN
          Length = 422

 Score =  135 bits (340), Expect = 2e-30
 Identities = 76/192 (39%), Positives = 106/192 (55%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y++MEF GS + +++M+ERM++ NM +EAGGK G+I  D VT  YL
Sbjct: 181 ILHIIGMIGVDGALYQAMEFTGSAIRAMDMDERMSISNMAIEAGGKAGLIEVDDVTRAYL 240

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+T  PY   +SD  A +   Y  D   + P V+ PH P N   A E +DVKI++  IG
Sbjct: 241 DGRTERPYTEYHSDADATYAKVYEIDAASIVPTVSFPHLPSNTRPAAEARDVKIDQAVIG 300

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCT G+  D   AA V L        V   ++PATQ V+             +    +F 
Sbjct: 301 SCTNGRIADMRQAADV-LRGRTVHPDVRCIVIPATQAVYRQCME--------EGLMDVFL 351

Query: 543 EAGCDTPASPSC 578
           +A C   ++P+C
Sbjct: 352 DANC-AVSTPTC 362

[79][TOP]
>UniRef100_C4G1B4 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1B4_ABIDE
          Length = 421

 Score =  135 bits (340), Expect = 2e-30
 Identities = 76/194 (39%), Positives = 115/194 (59%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEF G  +++L M++R T+ NM +EAG KNG+ P D +T  Y+
Sbjct: 179 ILHIIGKIGVDGALYKSMEFTGDGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTLNYI 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++ PY+   +D+ A +      ++++LEP VA PH P+N     E  D+KI++V IG
Sbjct: 239 KEHSTKPYKVYEADEDAVYDEVIEINLSELEPTVAFPHLPENTRTIGETGDIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AA+V     GKKV   +   ++PATQ+V++         S  +     
Sbjct: 299 SCTNGRISDIRVAAEVM---KGKKVAPGIRVIVIPATQEVYLT--------SLKEGLITT 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FVQAGC-IVSTPTC 360

[80][TOP]
>UniRef100_Q2RG98 3-isopropylmalate dehydratase large subunit n=1 Tax=Moorella
           thermoacetica ATCC 39073 RepID=LEUC_MOOTA
          Length = 421

 Score =  135 bits (340), Expect = 2e-30
 Identities = 69/161 (42%), Positives = 98/161 (60%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG I V GA Y +MEF G  + +L+ME R T+ NM +EAGGKNG+ P D  T +Y+
Sbjct: 179 ILYTIGRIGVDGARYMAMEFTGEAITNLSMEGRFTMANMAIEAGGKNGIFPVDEKTVEYI 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+    Y    SD  AR+  E   D +K+EP VA PH P+N    +E  ++KI++V IG
Sbjct: 239 RGRLQRDYRIYQSDPDARYNQEIDIDASKIEPQVALPHLPENARSVKEIGEIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA++     G+KV  +V   ++P TQ+++
Sbjct: 299 SCTNGRLEDLRVAAQIL---KGQKVHPEVRLIVIPGTQQIY 336

[81][TOP]
>UniRef100_C0R088 3-isopropylmalate dehydratase large subunit n=1 Tax=Brachyspira
           hyodysenteriae WA1 RepID=C0R088_BRAHW
          Length = 415

 Score =  135 bits (339), Expect = 3e-30
 Identities = 80/194 (41%), Positives = 109/194 (56%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V SL M++R  + NM +EAG KNG+   D  T +YL
Sbjct: 177 ILHIIGMIGVDGALYKSMEFRGEGVSSLTMDDRACIANMAIEAGAKNGIFEVDDQTIEYL 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +      Y    +D  A +  EY  D++ +EP VA PH P+N   A+E K++K+++V IG
Sbjct: 237 KDIVKRDYTVFKADDDAVYDKEYDIDLSLIEPTVACPHLPENTKEAKELKNIKVDQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AA +     GKKV   V   ++PATQKV+ +   L            I
Sbjct: 297 SCTNGRLSDMATAANIL---KGKKVAKGVRCIVIPATQKVYKECIKLGY--------MDI 345

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 346 FIDAGC-AVSTPTC 358

[82][TOP]
>UniRef100_C6LJ75 3-isopropylmalate dehydratase, large subunit n=1 Tax=Bryantella
           formatexigens DSM 14469 RepID=C6LJ75_9FIRM
          Length = 422

 Score =  135 bits (339), Expect = 3e-30
 Identities = 71/163 (43%), Positives = 105/163 (64%), Gaps = 3/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEF G  V++L+M++R T+ NM +EAGGKNG+ P D +   Y+
Sbjct: 179 ILHIIGMIGVDGALYRSMEFTGEGVKNLSMDDRFTIANMAIEAGGKNGIFPVDDLAIAYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYI 359
           +  +  PY+   +D+ A +  EY  D++ L+P VA PH P+N + +    +DV I++  I
Sbjct: 239 KEHSQRPYKIYEADEDAVYDEEYTIDLSALKPTVAFPHLPENTKTIDEITEDVVIDQAVI 298

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           GSCT G+ +D   AAK+     G+KVK  V   ++PATQKV++
Sbjct: 299 GSCTNGRIDDLRCAAKIL---EGRKVKKGVRCIVIPATQKVYL 338

[83][TOP]
>UniRef100_C0FIT9 Putative uncharacterized protein n=1 Tax=Clostridium sp. M62/1
           RepID=C0FIT9_9CLOT
          Length = 278

 Score =  135 bits (339), Expect = 3e-30
 Identities = 69/162 (42%), Positives = 102/162 (62%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  + +L+M++R T+CNM +EAGGKNG+ P D    +Y+
Sbjct: 36  ILHIIGMIGVDGALYKSMEFTGDGIRNLSMDDRFTICNMAIEAGGKNGIFPVDEKAVQYM 95

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +   ++   +D+ A + + Y  D++ L+P VA PH P+N     E  DV I++V IG
Sbjct: 96  KEHSKREFQIHEADEDAEYEAVYTIDLSALKPTVAFPHLPENTKTIDEAGDVAIDQVVIG 155

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+ ED   AA++     G+KVK  V   ++PATQ +++
Sbjct: 156 SCTNGRLEDMRIAAEIL---KGRKVKKGVRCIVIPATQAIYL 194

[84][TOP]
>UniRef100_B1I1Y2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Candidatus
           Desulforudis audaxviator MP104C RepID=B1I1Y2_DESAP
          Length = 420

 Score =  134 bits (338), Expect = 4e-30
 Identities = 70/159 (44%), Positives = 99/159 (62%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y++MEF G  + +L+M+ R T+ NM +EAG KNG+I PD  T +Y+
Sbjct: 179 ILYTIGDIGVEGALYQAMEFTGPAIANLSMDGRFTMANMAIEAGAKNGIIAPDIRTLEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+T  P+E   SD  A +     +DV+K+EP VA PHSPDN     E   V+I++V IG
Sbjct: 239 QGRTIRPFELFASDPDAVYARTITYDVSKIEPQVAFPHSPDNTRPVTEAGRVEIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVW 479
           SCT G+ ED   AA+V L        V   ++P TQ+++
Sbjct: 299 SCTNGRMEDLRLAARV-LERRRVHAGVRLIVIPGTQEIY 336

[85][TOP]
>UniRef100_C7H4B6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Faecalibacterium prausnitzii A2-165
           RepID=C7H4B6_9FIRM
          Length = 419

 Score =  134 bits (338), Expect = 4e-30
 Identities = 83/197 (42%), Positives = 112/197 (56%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V SL ME+R+ +CNM +EAG KNG+ P D VT  YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFTGPGVASLTMEDRLCVCNMAIEAGAKNGIFPVDEVTRAYL 238

Query: 183 EG---KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRV 353
            G   +T V YE   +D  A +      D+ KLEP V+ PH P+N   A E KD++I++V
Sbjct: 239 NGRSQRTPVYYE---ADPDAEYEKTIEIDLDKLEPTVSYPHLPENTHPASEGKDIRIDQV 295

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+ ED  AA  +     GK +   V   ++PAT  V+ +           +  
Sbjct: 296 VIGSCTNGRLEDMEAAYNIL---KGKHIAKGVRGIIIPATMAVYKECIL--------RGW 344

Query: 528 SQIFEEAGCDTPASPSC 578
           ++ F +AGC   ++P+C
Sbjct: 345 TEAFIDAGC-IVSTPTC 360

[86][TOP]
>UniRef100_A5ZAM9 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum
           ATCC 27560 RepID=A5ZAM9_9FIRM
          Length = 421

 Score =  134 bits (337), Expect = 5e-30
 Identities = 76/194 (39%), Positives = 112/194 (57%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEFVG  ++ L+M++R  + NM +EAGGKNG+ P D +T +Y+
Sbjct: 179 ILHIIGLIGVDGALYRSMEFVGDGIKYLSMDDRFAMTNMAIEAGGKNGIFPVDDLTIEYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y    +D+ A +  EY  D++ L P VA PH P+N     E  DVKI++V IG
Sbjct: 239 KEHSTKEYTVYEADEDAEYDEEYTIDLSTLRPTVAFPHLPENTRTIDEVGDVKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AAK+     G++V   V   + PATQ +++            +     
Sbjct: 299 SCTNGRIEDMRTAAKIL---EGREVAKGVRCIVFPATQAIYLQCIE--------EGIMTT 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FIKAGC-AVSTPTC 360

[87][TOP]
>UniRef100_A0RXN9 3-isopropylmalate dehydratase large subunit n=1 Tax=Cenarchaeum
           symbiosum RepID=A0RXN9_CENSY
          Length = 429

 Score =  134 bits (337), Expect = 5e-30
 Identities = 70/192 (36%), Positives = 113/192 (58%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG++   G  Y++M+F G+ +  +++E R+TL NM  EAG KNG+I  D  T  YL
Sbjct: 190 ILRIIGDMGTDGGAYRTMQFAGTGITEMSVEGRLTLANMTTEAGAKNGIIEADKKTAGYL 249

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             + +   + V  D  A +   + ++ +++EPLVAKP+SP+N ++ RE   V++++ YIG
Sbjct: 250 SSRGATGIKPVIGDDDAEYSEVFEYEGSEMEPLVAKPYSPENVSIVREAPSVELDKAYIG 309

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCTG K ED  AAA++     G+KV++ T ++PA   ++       + G        IF 
Sbjct: 310 SCTGAKMEDLEAAARIL---KGRKVRIRTEVLPAAISIYRKAVERGLVG--------IFL 358

Query: 543 EAGCDTPASPSC 578
           +AG  T   P+C
Sbjct: 359 DAGA-TVGPPTC 369

[88][TOP]
>UniRef100_Q2LWJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Syntrophus
           aciditrophicus SB RepID=LEUC_SYNAS
          Length = 420

 Score =  134 bits (337), Expect = 5e-30
 Identities = 71/161 (44%), Positives = 96/161 (59%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YK+MEF G T+ SL M +R T+ NM +EAGGKNG+  PD +T  Y+
Sbjct: 179 ILYIIGKIGVDGALYKAMEFTGDTIASLTMADRFTIANMAIEAGGKNGIFTPDEITEAYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +   PY    SD  A +      DV ++EP VA PH P N     E   V +++V IG
Sbjct: 239 KPRAKRPYTFYASDPDAAYAQVIEIDVNRIEPQVAFPHLPSNTKGISEVGQVPLDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED  AAA V     G+K   +V   ++PATQ+++
Sbjct: 299 SCTNGRIEDLRAAAAVL---KGRKADPRVRLIVIPATQEIY 336

[89][TOP]
>UniRef100_A8SZ55 Putative uncharacterized protein n=1 Tax=Coprococcus eutactus ATCC
           27759 RepID=A8SZ55_9FIRM
          Length = 461

 Score =  133 bits (335), Expect = 9e-30
 Identities = 68/162 (41%), Positives = 102/162 (62%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +++L M++R T+ NM +EAG KNG+ P D +T +Y+
Sbjct: 219 ILHIIGMIGVDGALYKSMEFVGEGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTEEYM 278

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y    +D+ A + +EY  D+++L+P VA PH P+N     E  D+KI++V IG
Sbjct: 279 KEHSTKSYTKYEADEDAVYDAEYTIDLSQLKPTVAFPHLPENTKTIDEVGDIKIDQVVIG 338

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   AA +     G+KV   V   ++P TQ +++
Sbjct: 339 SCTNGRISDMRIAADII---KGRKVADGVRVIVIPGTQDIYL 377

[90][TOP]
>UniRef100_A9KT79 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           phytofermentans ISDg RepID=LEUC_CLOPH
          Length = 421

 Score =  133 bits (335), Expect = 9e-30
 Identities = 75/194 (38%), Positives = 113/194 (58%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG+ +++L M++R T+ NM +EAG KNG+ P D +T  Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGAGIKNLTMDDRFTIANMAIEAGAKNGIFPVDDLTISYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +   + PY    +D+ A +      ++++LEP VA PH P+N    +E  +V+I++V IG
Sbjct: 239 KEHGAKPYTIYEADEDAEYEQIITINLSELEPTVAFPHLPENTKTVKEAGEVRIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AAKV     G+KV   +   + PATQ +++            +   Q 
Sbjct: 299 SCTNGRIGDLRIAAKVL---EGRKVAKGMRAIVFPATQAIYLQAIE--------EGLIQT 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FIKAGC-VVSTPTC 360

[91][TOP]
>UniRef100_A8S7H1 Putative uncharacterized protein n=1 Tax=Faecalibacterium
           prausnitzii M21/2 RepID=A8S7H1_9FIRM
          Length = 419

 Score =  133 bits (334), Expect = 1e-29
 Identities = 78/194 (40%), Positives = 109/194 (56%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V  L M++R+ +CNM +EAG KNG+ P D VT  YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFTGPGVAGLTMDDRLCICNMAIEAGAKNGIFPVDEVTKAYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G++  P     +D  A +      D++ LEP V+ PH P+N  +A E KD+KI++V IG
Sbjct: 239 AGRSQRPPVFYEADPDAVYEKTIEIDLSALEPTVSYPHLPENTHVASEGKDIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED  AA  +     GK +   V   ++PAT  V+ +           +  +  
Sbjct: 299 SCTNGRLEDMEAAYNIL---KGKHIAKGVRGIIIPATMAVYKECIL--------RGWTTA 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FIDAGC-IVSTPTC 360

[92][TOP]
>UniRef100_UPI00016C08CB 3-isopropylmalate dehydratase, large subunit n=1 Tax=Epulopiscium
           sp. 'N.t. morphotype B' RepID=UPI00016C08CB
          Length = 421

 Score =  132 bits (333), Expect = 1e-29
 Identities = 71/163 (43%), Positives = 99/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  ++ L+M+ R T+ NM +EAG KNG+   D +T +YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGIQHLSMDSRFTMANMAIEAGAKNGIFEVDFITREYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+T   Y    SD  A +      D++K+ P V+ PHSPDN     E  ++KI++V IG
Sbjct: 239 KGRTDREYIVYTSDADAIYDEVITIDLSKVRPTVSCPHSPDNTXTLDELPEIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           SCT G+ ED   A+ +     GKKV   V   + P TQ++++D
Sbjct: 299 SCTNGRLEDLRMASDIL---KGKKVAKGVRAIVFPGTQQIYLD 338

[93][TOP]
>UniRef100_B4U7U5 3-isopropylmalate dehydratase large subunit n=1
           Tax=Hydrogenobaculum sp. Y04AAS1 RepID=LEUC_HYDS0
          Length = 424

 Score =  132 bits (333), Expect = 1e-29
 Identities = 72/191 (37%), Positives = 109/191 (57%), Gaps = 2/191 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y++MEF G  + SL++ +R+T+ NM +EAGGK+G+I PD  T +Y+
Sbjct: 178 ILYTIGQIGVDGALYRAMEFDGEAIRSLDVSQRLTIANMAIEAGGKSGIISPDEKTIEYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +   PY+   SD+ A ++  Y +D + +EP+VA P+ P N     E   + I++ +IG
Sbjct: 238 EKRAKKPYKIYQSDKDAHYVEVYEWDASSIEPMVAWPYLPSNVHPVSESTHITIDQAFIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AA +     GKKV   T   ++PA++ V++            +    I
Sbjct: 298 SCTNGRIEDLRIAASIL---KGKKVHPYTRCVVIPASKNVYLQALH--------EGLVDI 346

Query: 537 FEEAGCDTPAS 569
           F EAGC    S
Sbjct: 347 FIEAGCAVSTS 357

[94][TOP]
>UniRef100_Q3AEQ4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AEQ4_CARHZ
          Length = 421

 Score =  132 bits (332), Expect = 2e-29
 Identities = 75/194 (38%), Positives = 112/194 (57%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YK+MEF GS ++ +++E R+T+ NM +EAG KNG+ P D +T +Y+
Sbjct: 180 ILFIIGQIGVDGALYKAMEFAGSALKLISVEGRLTMANMAIEAGAKNGIFPVDELTLEYV 239

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    ++   SD  AR+ + Y  +V ++EP VA PH P+N    +E     I++V IG
Sbjct: 240 KGRAKREFKVFASDPDARYEAVYEINVEEIEPQVALPHLPENAVPVKEVSGKDIDQVVIG 299

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AA +     GKKVK  V   ++P +Q V+             +    I
Sbjct: 300 SCTNGRIEDLRVAAAIL---KGKKVKDYVRCIIIPGSQSVYRQALK--------EGLIDI 348

Query: 537 FEEAGCDTPASPSC 578
           F EAG    ++P+C
Sbjct: 349 FLEAGA-AVSTPTC 361

[95][TOP]
>UniRef100_C1TNL5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dethiosulfovibrio peptidovorans DSM 11002
           RepID=C1TNL5_9BACT
          Length = 419

 Score =  132 bits (332), Expect = 2e-29
 Identities = 71/161 (44%), Positives = 96/161 (59%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL ++ EI+V GA Y ++EF G  + S++M+ R T+ NM VEAGGK G+  PD  T  Y 
Sbjct: 177 ILAVLREISVQGARYMALEFGGDALASMSMDHRFTVANMAVEAGGKAGLFVPDETTLAYA 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E + S P+ + Y D+   +      DV KL PLVA PHSPDN   A    D +I +V+IG
Sbjct: 237 EARASRPFTARYPDEGCEYAKRVEIDVEKLTPLVAAPHSPDNVRPASTFGDTEIQQVFIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED  AAA V     GKKV   V   ++PA+ +V+
Sbjct: 297 SCTNGRLEDMAAAASVL---EGKKVHPSVRCIVIPASYEVY 334

[96][TOP]
>UniRef100_A8RZ58 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8RZ58_9CLOT
          Length = 420

 Score =  132 bits (332), Expect = 2e-29
 Identities = 72/194 (37%), Positives = 113/194 (58%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  + +L+M++R T+CNM +EAGGKNG+ P D +  +Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGEGIRNLSMDDRFTICNMAIEAGGKNGIFPVDELAVEYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +   +    +D+ A +   Y  D+++L+P V+ PH P N     +  +VK+++  IG
Sbjct: 239 KEHSKREFTVYEADEDAEYDETYVIDLSELKPTVSFPHLPSNTRTIDQVGEVKVDQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AA+V     G+K+   V   ++PATQ +++            +   +I
Sbjct: 299 SCTNGRIEDMRIAAEVL---KGRKIAKGVRCIVIPATQSIYLQAMK--------EGLLEI 347

Query: 537 FEEAGCDTPASPSC 578
           F EAG    ++P+C
Sbjct: 348 FIEAGA-VVSTPTC 360

[97][TOP]
>UniRef100_C8SB74 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SB74_FERPL
          Length = 419

 Score =  132 bits (332), Expect = 2e-29
 Identities = 76/160 (47%), Positives = 101/160 (63%), Gaps = 4/160 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG +   GA YK+ EFVGST+E + M ER+T+ NM +E GGK G+IPPD VT  YL
Sbjct: 178 ILKIIGTVGANGANYKACEFVGSTIEKMEMSERLTMTNMAIEMGGKTGIIPPDKVTEDYL 237

Query: 183 EGKTSVPYES---VYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRV 353
           +    V YE    +YSD+ A +  E   DV+ LEP VA PHS DN     E + VKI++V
Sbjct: 238 K-SIGVDYEIPEWLYSDEDA-YWKEVSLDVSNLEPQVACPHSVDNVKPVSEVEGVKIDQV 295

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVK-VPTFLVPATQ 470
           +IGSCT G+ ED   AA++    G K  K V   ++PA++
Sbjct: 296 FIGSCTNGRYEDLKVAAEIL--KGEKVAKGVRLIVIPASR 333

[98][TOP]
>UniRef100_Q2FSZ6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanospirillum hungatei JF-1 RepID=Q2FSZ6_METHJ
          Length = 417

 Score =  132 bits (331), Expect = 3e-29
 Identities = 72/162 (44%), Positives = 100/162 (61%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL II +ITV GATYK++EF G T+ESLNM  RMT CNM +E GGK G++PPD VT +YL
Sbjct: 176 ILNIIKDITVDGATYKTVEFTGDTIESLNMAGRMTCCNMAIEMGGKAGIVPPDQVTKEYL 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+ +   E++ SD  A + S   +DV+ L P VA PH+ D      E     +++V+IG
Sbjct: 236 SGRGTWREENLASDPDAVYASWRDYDVSDLVPQVAVPHNVDQVVDVTEIAGTHVDQVFIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+ ED   AA   L  G +K    V   ++PA++  ++
Sbjct: 296 SCTNGRFEDLKEAA---LVLGDRKFSDDVRVLVIPASKTEYL 334

[99][TOP]
>UniRef100_Q0W1Q4 3-isopropylmalate dehydratase, large subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W1Q4_UNCMA
          Length = 414

 Score =  132 bits (331), Expect = 3e-29
 Identities = 65/161 (40%), Positives = 98/161 (60%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+I  E+   GATYK+MEF G  ++ +++  RMTLCNM +E GGK G++PPD  T+ +L
Sbjct: 176 ILRIAKEVGSDGATYKAMEFYGPVIDHMSIAGRMTLCNMAIEMGGKAGIVPPDEKTFAFL 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    Y  VY+ + A +  E   DV+KL P V+ P   DN     E +   +++V IG
Sbjct: 236 KGRAVEEYRPVYASRDAVYCDELHLDVSKLHPQVSCPPDVDNVKDVGEVEGTHVDQVLIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           SCT G+ ED   AA +     G+KV+  T ++PA++ V +D
Sbjct: 296 SCTNGRYEDLAGAAAIL---KGRKVRCRTLIIPASRSVMLD 333

[100][TOP]
>UniRef100_C9L6F6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Blautia
           hansenii DSM 20583 RepID=C9L6F6_RUMHA
          Length = 425

 Score =  131 bits (329), Expect = 4e-29
 Identities = 75/193 (38%), Positives = 112/193 (58%), Gaps = 1/193 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG+I V GA YKS+EF G  V++L+M++R T+ NM +EAG KNG+ P D  T +Y+
Sbjct: 182 ILHLIGKIGVDGALYKSLEFTGEGVKNLSMDDRFTIANMAIEAGAKNGIFPVDEKTEEYM 241

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK-DVKINRVYI 359
           +  +  PY+    D+ A +  EY  D++KL P VA PH P N     E + DV I +  I
Sbjct: 242 KEHSKRPYKRYEPDEDAVYDEEYTIDLSKLRPTVAFPHLPSNTKTIDEIQDDVIIQQSVI 301

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIF 539
           GSCT G+ +D   AA++ L +   K  V   ++PATQK+++            +   +IF
Sbjct: 302 GSCTNGRIDDLRCAAQI-LKNRKVKKGVRCIIIPATQKIYLQALE--------EGLLKIF 352

Query: 540 EEAGCDTPASPSC 578
            EAG    ++P+C
Sbjct: 353 IEAGA-VVSTPTC 364

[101][TOP]
>UniRef100_C0D3T2 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0D3T2_9CLOT
          Length = 446

 Score =  131 bits (329), Expect = 4e-29
 Identities = 75/194 (38%), Positives = 111/194 (57%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V++L M++R T+CNM +EAGGKNG+ P D  T  YL
Sbjct: 205 ILHIIGMIGVDGALYKSMEFTGEGVKNLTMDDRFTICNMAIEAGGKNGIFPVDEQTVAYL 264

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +   ++   +D  A + + Y  D+++L+P V+ PH P N        DVKI++  IG
Sbjct: 265 KEHSKRDFKVYEADPDAEYDATYVIDLSELKPTVSFPHLPSNTRTIDNVGDVKIDQSVIG 324

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ +D   AA++     G+KV   V   ++PATQ +++            +   +I
Sbjct: 325 SCTNGRIDDMRVAAEIL---KGRKVAKNVRCIVIPATQAIYLQAMR--------EGLLEI 373

Query: 537 FEEAGCDTPASPSC 578
           F EAG    ++P+C
Sbjct: 374 FVEAGA-IVSTPTC 386

[102][TOP]
>UniRef100_A4XJ48 3-isopropylmalate dehydratase large subunit n=1
           Tax=Caldicellulosiruptor saccharolyticus DSM 8903
           RepID=LEUC_CALS8
          Length = 429

 Score =  131 bits (329), Expect = 4e-29
 Identities = 74/195 (37%), Positives = 113/195 (57%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSME+ G  ++SL+M++R T+ NM +EAG KNG+   D  T +Y+
Sbjct: 181 ILHIIGMIGVDGALYKSMEYTGEGLKSLSMDDRFTIANMAIEAGAKNGIFEVDEKTIEYV 240

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYI 359
           +  ++ PY+   +D+ A +   Y  D++K+ P VA PH P+N     E  + + I++V I
Sbjct: 241 KQHSTKPYKIFKADEDAEYSEVYEIDISKIRPTVAFPHLPENTKTIDEITEKIYIDQVVI 300

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AAK+     G+KVK  +   + PATQ ++             +   +
Sbjct: 301 GSCTNGRIEDLRIAAKIL---KGRKVKKGLRCIIFPATQNIYKQALK--------EGLIE 349

Query: 534 IFEEAGCDTPASPSC 578
           IF +AGC   ++P+C
Sbjct: 350 IFIDAGC-VVSTPTC 363

[103][TOP]
>UniRef100_B0PBC0 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis
           DSM 17241 RepID=B0PBC0_9FIRM
          Length = 419

 Score =  130 bits (328), Expect = 6e-29
 Identities = 74/194 (38%), Positives = 109/194 (56%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEF G  +  L+M++R+T+ NM +EAGGKNG+   D VT  Y+
Sbjct: 179 ILHIIGMIGVDGALYQSMEFGGEGLRHLSMDDRLTMANMAIEAGGKNGIFEVDEVTRAYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+ +  YE+   D  A +      D++ + P VA PH P+N     E  DV+I++V IG
Sbjct: 239 QGRVNRTYETFMPDDGAAYARVIEIDLSSIRPTVAFPHLPENTRTVDEAGDVRIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D  AAA++     GKKV   V   ++P TQ+++ +                 
Sbjct: 299 SCTNGRIGDLAAAARLM---SGKKVADGVRCIVIPGTQQIYREAIHAGY--------IDT 347

Query: 537 FEEAGCDTPASPSC 578
           F +AGC   ++P+C
Sbjct: 348 FLDAGC-AVSTPTC 360

[104][TOP]
>UniRef100_C7II84 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           papyrosolvens DSM 2782 RepID=C7II84_9CLOT
          Length = 419

 Score =  130 bits (327), Expect = 7e-29
 Identities = 67/161 (41%), Positives = 99/161 (61%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V +L+M++R ++ NM +EAG KNG+   D  T +Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFTGDGVNALSMDDRFSMANMAIEAGAKNGIFEVDEKTVEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +   Y    +D+ A++   Y  D+ +++P VA PH P+N     +  D+KI++V IG
Sbjct: 239 KEHSIRSYTVYKADEDAQYSEVYEIDLAEIKPTVAFPHLPENARTIDKVGDIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA++     G+KV   V   ++PATQK+W
Sbjct: 299 SCTNGRIEDMRIAAQIL---KGQKVSDNVRCIIIPATQKIW 336

[105][TOP]
>UniRef100_C0CLF7 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CLF7_9FIRM
          Length = 422

 Score =  130 bits (327), Expect = 7e-29
 Identities = 74/195 (37%), Positives = 114/195 (58%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D +   Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGIQHLSMDDRFTIANMAIEAGGKNGIFPVDDLAVAYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKDVKINRVYI 359
              +   ++   +D+ A +  EY  D+++L+P +A PH P+N R +     DV I++  I
Sbjct: 239 REHSKREFKIYEADEDAVYEEEYTIDLSQLKPTIAFPHLPENTRTIDEITADVVIDQSVI 298

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AA++     G+KVK  +   ++PATQ +++            +   +
Sbjct: 299 GSCTNGRMEDLRIAAEIL---KGRKVKKGIRCIVIPATQAIYLQAMK--------EGLLE 347

Query: 534 IFEEAGCDTPASPSC 578
           IF EAG    ++P+C
Sbjct: 348 IFIEAGA-VVSTPTC 361

[106][TOP]
>UniRef100_B1C4Q4 Putative uncharacterized protein n=1 Tax=Clostridium spiroforme DSM
           1552 RepID=B1C4Q4_9FIRM
          Length = 424

 Score =  130 bits (327), Expect = 7e-29
 Identities = 80/199 (40%), Positives = 111/199 (55%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL II +I V GA YKSMEFVG  ++ L M++R T+CNM +EAG KNG+ P D  T  Y+
Sbjct: 178 ILHIINKIGVDGALYKSMEFVGDGIQYLTMDDRFTICNMAIEAGAKNGIFPVDDQTIAYM 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
           E  +   Y+   +D+ A +      D++K+ P VA PH P N     E    + + I++V
Sbjct: 238 EEHSKKDYKVYTADEDAEYERVIEIDLSKVRPTVAFPHLPGNGHTIDEIEAMEPIYIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+  D   AA +     GKKV   V   +VPATQK+++      V G      
Sbjct: 298 VIGSCTNGRISDLRKAAAIL---KGKKVARNVRVMVVPATQKIFLQCI---VEG-----L 346

Query: 528 SQIFEEAGC--DTPASPSC 578
           ++IF EAGC  +TP+   C
Sbjct: 347 AEIFVEAGCAFNTPSCGPC 365

[107][TOP]
>UniRef100_A7VIP8 Putative uncharacterized protein n=1 Tax=Clostridium sp. L2-50
           RepID=A7VIP8_9CLOT
          Length = 441

 Score =  130 bits (327), Expect = 7e-29
 Identities = 68/162 (41%), Positives = 99/162 (61%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +++L M++R T+ NM +EAG KNG+ P D +T  Y+
Sbjct: 199 ILHIIGMIGVDGALYKSMEFVGDGIKNLTMDDRFTIANMAIEAGAKNGIFPVDELTEAYM 258

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y+   +D  A +  EY  D++ L P VA PH P+N     E  D+KI++V IG
Sbjct: 259 KEHSTKAYKKYEADADAVYDEEYTIDLSTLRPTVAFPHLPENTKTIDEVGDIKIDQVVIG 318

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   AA +     G++V   V   ++P TQ+V++
Sbjct: 319 SCTNGRISDMRIAADII---KGRQVAPGVRVIVIPGTQEVYL 357

[108][TOP]
>UniRef100_Q6LY44 3-isopropylmalate dehydratase n=1 Tax=Methanococcus maripaludis
           RepID=Q6LY44_METMP
          Length = 424

 Score =  130 bits (327), Expect = 7e-29
 Identities = 65/166 (39%), Positives = 98/166 (59%), Gaps = 5/166 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +   GATYK+ +F G+TV+++ +  RMT+ NM +E GGK G+I PD  T  Y+
Sbjct: 178 ILSIIGMVGADGATYKAAQFAGNTVDNMTIASRMTMSNMAIEMGGKAGLIAPDDKTINYV 237

Query: 183 EG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T+ P+E V  D+ A F  ++  DV+ LEP++A PH+ DN    RE     I+
Sbjct: 238 KNAMEANNTAKPFELVLGDKNAEFEEKFEIDVSNLEPVMACPHNVDNVKAVREVAGTPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           +V+IGSCT G+ ED  AA  V    GG    +   + PA++ + ++
Sbjct: 298 QVFIGSCTNGRLEDLRAALNVIEKHGGISKDIRVVVTPASRSIMLE 343

[109][TOP]
>UniRef100_A4FX22 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanococcus
           maripaludis C5 RepID=A4FX22_METM5
          Length = 424

 Score =  130 bits (327), Expect = 7e-29
 Identities = 64/166 (38%), Positives = 99/166 (59%), Gaps = 5/166 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +   GATYK+ +F G+TV+++ +  RMT+ NM +E GGK G+I PD  T  Y+
Sbjct: 178 ILSIIGMVGADGATYKAAQFAGNTVDNMTIASRMTMSNMAIEMGGKAGLIAPDDKTINYV 237

Query: 183 EG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T+ P+E +  D+ A F  ++  DV+ LEP++A PH+ DN    RE     I+
Sbjct: 238 KNAMEMNNTAKPFEFILGDKDAEFEKKFEIDVSNLEPVMACPHNVDNVKAVREVAGTPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           +V+IGSCT G+ ED  AA +V    GG    +   + PA++ + ++
Sbjct: 298 QVFIGSCTNGRLEDLRAALEVIEKHGGISKDIRVVVTPASRSIMLE 343

[110][TOP]
>UniRef100_B1C9W1 Putative uncharacterized protein n=1 Tax=Anaerofustis
           stercorihominis DSM 17244 RepID=B1C9W1_9FIRM
          Length = 424

 Score =  130 bits (326), Expect = 1e-28
 Identities = 68/167 (40%), Positives = 102/167 (61%), Gaps = 2/167 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA Y+SMEF G  ++ L+M++R ++ NM +EAG KNG+ P D  T +Y 
Sbjct: 179 ILHIIGKIGVDGALYRSMEFTGDGIKYLSMDDRFSMANMAIEAGAKNGIFPVDDKTIEYA 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  +E   +D+ A++      D++KL P V+ PH P+N     E   V I++  IG
Sbjct: 239 KEHSTKTFEVFEADEDAQYDEVIEIDLSKLRPTVSFPHLPENTKTVDEAGKVYIDQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL 497
           SCT G+ ED   AA +     GK+V  KV T ++PATQK+++D   L
Sbjct: 299 SCTNGRLEDIKMAADIL---RGKQVDKKVRTIVIPATQKIYLDSIKL 342

[111][TOP]
>UniRef100_A8AB09 3-isopropylmalate dehydratase, large subunit n=1 Tax=Ignicoccus
           hospitalis KIN4/I RepID=A8AB09_IGNH4
          Length = 419

 Score =  130 bits (326), Expect = 1e-28
 Identities = 76/186 (40%), Positives = 108/186 (58%), Gaps = 2/186 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +TV GATYK++E+ G T++ +N+ +RMTL NM VE G K G++P D VT K+ 
Sbjct: 179 ILHIIGTVTVDGATYKAVEYHGDTIKRMNIADRMTLANMSVEMGAKAGMVPADEVTVKFF 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +  +  +    D  A++   + FDV+KLEP VA PHS DN     E +   I++ +IG
Sbjct: 239 E-EAGISVKPFGPDPGAQYEDVWEFDVSKLEPQVAVPHSVDNVVAVGEVEGTPIDQAFIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ EDF+ AAK+     G+KV   V    +PA+ K +M +          +    I
Sbjct: 298 SCTNGRYEDFVEAAKIL---KGRKVAPGVRCIAIPASLKQYMRLLK--------EGIIDI 346

Query: 537 FEEAGC 554
             EAGC
Sbjct: 347 LTEAGC 352

[112][TOP]
>UniRef100_Q3Z9A7 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides
           ethenogenes 195 RepID=Q3Z9A7_DEHE1
          Length = 417

 Score =  129 bits (325), Expect = 1e-28
 Identities = 68/166 (40%), Positives = 101/166 (60%), Gaps = 1/166 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I   GATYK++EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL
Sbjct: 175 ILYLIGLIGADGATYKALEFSGNVVNNMTIAERLTIANMAVEAGAKVGLFPSDRQTLEYL 234

Query: 183 EGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
                   Y+ + +D+ A +      D T LEP+VAKPH+ DN A ARE K  K+++V+I
Sbjct: 235 RSVGREADYQPLAADEDAVYERVIEIDATALEPMVAKPHTVDNTATARELKGTKLDQVFI 294

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSL 497
           G+CTGG+ +D   AA +F  +     +    + PA+QKV+++   L
Sbjct: 295 GTCTGGRLDDLAVAAAIF-KNRRHHPQTRLIVTPASQKVYLEAIRL 339

[113][TOP]
>UniRef100_B9E370 Putative uncharacterized protein n=1 Tax=Clostridium kluyveri NBRC
           12016 RepID=B9E370_CLOK1
          Length = 426

 Score =  129 bits (324), Expect = 2e-28
 Identities = 74/194 (38%), Positives = 109/194 (56%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y SMEF G  V  L+M++R T+ NM +EAG KNG+ P D  T +Y+
Sbjct: 185 ILHIIGMIGVDGALYNSMEFTGEGVGELSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYV 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y    +D+ A ++     D++K+ P VA PH P+N     E  ++KI++V IG
Sbjct: 245 KEHSNRSYTVYEADEDAEYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEIKIDQVVIG 304

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AAKV     G+KV   V T + PATQ +++            +   +I
Sbjct: 305 SCTNGRIGDLRVAAKVL---KGRKVNSNVRTIIFPATQSIYLQAMK--------EGLLEI 353

Query: 537 FEEAGCDTPASPSC 578
           F E+G    ++P+C
Sbjct: 354 FIESGA-VVSTPTC 366

[114][TOP]
>UniRef100_B1QZX5 3-isopropylmalate dehydratase, large subunit n=2 Tax=Clostridium
           butyricum RepID=B1QZX5_CLOBU
          Length = 419

 Score =  129 bits (324), Expect = 2e-28
 Identities = 68/162 (41%), Positives = 96/162 (59%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDEKTEEYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +      ++   +D+ A++   Y  D++ L P V+ PH PDN        DVKI++V IG
Sbjct: 239 KDHAKREWKKYEADEDAQYDEVYEIDLSTLRPTVSFPHLPDNTRTIDNTGDVKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SCT G+  D   A  +     GKKV   +   ++P TQK+++
Sbjct: 299 SCTNGRISDLRVARDIL---KGKKVDKTIRCIVIPGTQKIYL 337

[115][TOP]
>UniRef100_A5MZ75 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           kluyveri DSM 555 RepID=LEUC_CLOK5
          Length = 420

 Score =  129 bits (324), Expect = 2e-28
 Identities = 74/194 (38%), Positives = 109/194 (56%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y SMEF G  V  L+M++R T+ NM +EAG KNG+ P D  T +Y+
Sbjct: 179 ILHIIGMIGVDGALYNSMEFTGEGVGELSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y    +D+ A ++     D++K+ P VA PH P+N     E  ++KI++V IG
Sbjct: 239 KEHSNRSYTVYEADEDAEYVKTIEIDLSKIPPTVAFPHIPENTRTIDEVGEIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AAKV     G+KV   V T + PATQ +++            +   +I
Sbjct: 299 SCTNGRIGDLRVAAKVL---KGRKVNSNVRTIIFPATQSIYLQAMK--------EGLLEI 347

Query: 537 FEEAGCDTPASPSC 578
           F E+G    ++P+C
Sbjct: 348 FIESGA-VVSTPTC 360

[116][TOP]
>UniRef100_A6LPX4 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           beijerinckii NCIMB 8052 RepID=LEUC_CLOB8
          Length = 419

 Score =  129 bits (324), Expect = 2e-28
 Identities = 68/162 (41%), Positives = 98/162 (60%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  ++ L+M++R T+ NM +EAGGKNG+ P D  T +YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGLQYLSMDDRFTMANMAIEAGGKNGIFPVDDKTEEYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +   S  ++   +D+ A +   +  D+++L P V+ PH PDN        DV I++V IG
Sbjct: 239 KDHASREWKVYEADEDAEYDKVFEIDLSELRPTVSFPHLPDNTRTIDNTGDVAIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   A  +     GKKVK  +   ++P TQK+++
Sbjct: 299 SCTNGRISDLRMARDIL---KGKKVKKGIRCIVIPGTQKIYL 337

[117][TOP]
>UniRef100_B9MLV4 3-isopropylmalate dehydratase large subunit n=1 Tax=Anaerocellum
           thermophilum DSM 6725 RepID=LEUC_ANATD
          Length = 429

 Score =  129 bits (324), Expect = 2e-28
 Identities = 73/195 (37%), Positives = 113/195 (57%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSME+ G  ++SL+M++R T+ NM +EAG KNG+   D  T +Y+
Sbjct: 181 ILHIIGMIGVDGALYKSMEYTGEGLKSLSMDDRFTIANMAIEAGAKNGIFEVDEKTIEYV 240

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYI 359
           +  ++ PY+   +D+ A +   +  D++K+ P VA PH P+N     E  + + I++V I
Sbjct: 241 KQHSTKPYKIFKADEDAEYSQVFEIDISKIRPTVAFPHLPENTKTIDEITEKIYIDQVVI 300

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AAK+     G+KVK  +   + PATQ ++             +   +
Sbjct: 301 GSCTNGRIEDLRIAAKIL---KGRKVKKGLRCIIFPATQNIYKQALK--------EGFIE 349

Query: 534 IFEEAGCDTPASPSC 578
           IF +AGC   ++P+C
Sbjct: 350 IFIDAGC-VVSTPTC 363

[118][TOP]
>UniRef100_B8GJ01 Homoaconitate hydratase family protein n=1 Tax=Methanosphaerula
           palustris E1-9c RepID=B8GJ01_METPE
          Length = 419

 Score =  129 bits (323), Expect = 2e-28
 Identities = 67/160 (41%), Positives = 96/160 (60%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I   GATYK++EF GST+  + M  RMTL NM +E GGK G++PPD VT+ YL
Sbjct: 179 ILSIIGDIGADGATYKAVEFAGSTIRGMEMPGRMTLSNMAIEMGGKAGIVPPDQVTWDYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +  V    + SD+ A F  + R+DVT L P VA PH+ D+     E     +++V+IG
Sbjct: 239 KSRRQVTPFELDSDEDATFADQRRYDVTNLVPKVAVPHNVDHVVDVTEVAGTHLDQVFIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
           SCT G+ ED   AA V L        +   ++PA++  ++
Sbjct: 299 SCTNGRFEDLAEAAAV-LGDRNFSEDLRVLVIPASRDEYL 337

[119][TOP]
>UniRef100_A3DHI4 3-isopropylmalate dehydratase large subunit n=3 Tax=Clostridium
           thermocellum RepID=LEUC_CLOTH
          Length = 419

 Score =  129 bits (323), Expect = 2e-28
 Identities = 66/161 (40%), Positives = 99/161 (61%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEF G  V  L+M++R  + NM +EAG KNG+   D  T +Y+
Sbjct: 179 ILHIIGMIGVDGALYRSMEFTGDGVAHLSMDDRFAMANMAIEAGAKNGIFEVDEKTIEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y+   +D+ A +++ Y  D+++++P VA PH P N        ++KI++V IG
Sbjct: 239 KEHSTRQYKVYKADEDAEYVATYEIDLSQVKPTVAFPHLPSNTRTIDNVGNIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA+V     G+KV   V   ++PATQK+W
Sbjct: 299 SCTNGRIEDLRVAAEVL---KGRKVHKDVRCIIIPATQKIW 336

[120][TOP]
>UniRef100_Q0AV21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Syntrophomonas
           wolfei subsp. wolfei str. Goettingen RepID=Q0AV21_SYNWW
          Length = 419

 Score =  128 bits (322), Expect = 3e-28
 Identities = 64/163 (39%), Positives = 98/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y SMEF G  +++L+M+ R T+ NM +EAGGKNG+   D +T  Y+
Sbjct: 179 ILHTIGDIGVDGARYMSMEFTGEVIQNLSMDNRFTMANMAIEAGGKNGIFAADEITLDYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +   P+E   SD  A +     +DV+KLEP+VA PH P+N     E   V +++V IG
Sbjct: 239 KKRVKRPFELYQSDPDAVYFDIKEYDVSKLEPVVAFPHLPENTRPVTEATHVSLDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+ ED    A +     G+KV  ++   + P T++++++
Sbjct: 299 SCTNGRIEDMEITASLL---KGQKVHPEIRVIIFPGTREIYLE 338

[121][TOP]
>UniRef100_B8I4G0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I4G0_CLOCE
          Length = 419

 Score =  128 bits (322), Expect = 3e-28
 Identities = 68/161 (42%), Positives = 96/161 (59%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V +L+M++R ++ NM +EAG KNG+   D  T +Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEFTGDGVNALSMDDRFSMANMAIEAGAKNGIFEVDEKTVEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  +   Y    +D+ A +   Y  D+ +++P VA PH P+N        D+KI++V IG
Sbjct: 239 KEHSIRHYTVYKADEDAEYSEVYEIDLAEVKPTVAFPHLPENARTIDNVGDIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA V     G+KV   V   ++PATQK+W
Sbjct: 299 SCTNGRIEDMRIAAGVL---KGRKVSDNVRCIIIPATQKIW 336

[122][TOP]
>UniRef100_A0LMK9 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMK9_SYNFM
          Length = 419

 Score =  128 bits (322), Expect = 3e-28
 Identities = 74/194 (38%), Positives = 105/194 (54%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y++MEF G  ++ L M +R ++CNM +EAG K G+I PD VT +Y+
Sbjct: 179 ILYTIGQIGVDGARYRAMEFTGEVIDRLPMSDRFSMCNMAIEAGAKAGIIAPDPVTEEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    YE   SD  A F S + +DV+  EP+VA PHSP N           I++V IG
Sbjct: 239 KGRAKRSYEFYRSDPDAAFESVHEWDVSAFEPMVALPHSPANVRPVSRIPRTVIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AA +     G+KV   V   ++PAT++++            G   + +
Sbjct: 299 SCTNGRYEDLETAAAIL---KGRKVAPGVRCMIIPATREIYRQAL------RNGLLETFV 349

Query: 537 FEEAGCDTPASPSC 578
             EA   TP    C
Sbjct: 350 DAEAAVSTPTCGPC 363

[123][TOP]
>UniRef100_C6PQI2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           carboxidivorans P7 RepID=C6PQI2_9CLOT
          Length = 421

 Score =  128 bits (322), Expect = 3e-28
 Identities = 72/192 (37%), Positives = 110/192 (57%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSME+ G  +++L+M++R T+ NM +EAG KNG+   D  T +Y+
Sbjct: 179 ILHIIGMIGVDGALYKSMEYTGEGLKNLSMDDRFTMANMAIEAGAKNGIFEVDDKTIEYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y    +D+ A +      D++ + P VA PH P+N     E  +V I++  IG
Sbjct: 239 KEHSNREYTVYTADEDAEYSKVIEIDLSSIRPTVAFPHLPENTRTIDEVGEVFIDQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCT G+ ED  AAAKVF  +   K +V   + PATQK++++           +   +IF 
Sbjct: 299 SCTNGRIEDLRAAAKVFKGNKVNK-RVRAIIFPATQKIYLEALR--------EGLLEIFI 349

Query: 543 EAGCDTPASPSC 578
           EAG    ++P+C
Sbjct: 350 EAGA-VVSTPTC 360

[124][TOP]
>UniRef100_C0B4W1 Putative uncharacterized protein n=1 Tax=Coprococcus comes ATCC
           27758 RepID=C0B4W1_9FIRM
          Length = 417

 Score =  128 bits (322), Expect = 3e-28
 Identities = 67/161 (41%), Positives = 97/161 (60%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+   G  Y+ MEF G   ++L + +R+ LCNM VEAG K G+   D V  +YL
Sbjct: 177 ILTIIGEVGANGCNYQVMEFTGEGAKTLTISDRIALCNMAVEAGAKTGIFEVDDVAMEYL 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +     P    +SD  A ++ EY FD++K+EP+VAKP   DN A A++ + +KI+  ++G
Sbjct: 237 KEHGREPKAVYHSDPDAHYVREYTFDLSKVEPVVAKPDFVDNLAPAKDVRGIKIDEAFLG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SC  G+ ED    A+V     GKKV  KV   +VPA+Q ++
Sbjct: 297 SCNNGRIEDLRVGAQVI---KGKKVSEKVRFLVVPASQTIY 334

[125][TOP]
>UniRef100_Q2NE97 LeuC1 n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NE97_METST
          Length = 418

 Score =  128 bits (322), Expect = 3e-28
 Identities = 67/161 (41%), Positives = 102/161 (63%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I   GA YK+ E+ G TV++++M +RM L NM +E GGK G++P D +T +YL
Sbjct: 178 ILNIIGQIGQDGARYKACEYTGETVQNMDMSDRMVLSNMAIECGGKTGIVPADKITDEYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +T+  Y    +D+ A  L     DV+ LEP VA P+  DN   A E +DV+I++V+IG
Sbjct: 238 KNRTTKQYTKFTTDKDAASLEVMDIDVSDLEPQVACPNYVDNVKPASEVEDVEIDQVFIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVW 479
           SCT G+ +D   AA+V     G K+   V T ++PA++ ++
Sbjct: 298 SCTNGRLKDLEQAARVL---KGNKINPGVRTLVIPASRTIY 335

[126][TOP]
>UniRef100_A6VG92 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C7 RepID=A6VG92_METM7
          Length = 424

 Score =  128 bits (322), Expect = 3e-28
 Identities = 64/166 (38%), Positives = 98/166 (59%), Gaps = 5/166 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +   GATYK+ +F G+TV+++ +  RM++ NM +E GGK G+I PD  T  Y+
Sbjct: 178 ILSIIGMVGADGATYKAAQFAGNTVDNMTIASRMSMSNMAIEMGGKAGLIAPDDKTINYV 237

Query: 183 EG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T+ P+E +  D+ A F  ++  +V  LEP++A PH+ DN    RE     I+
Sbjct: 238 KNAMETNNTAKPFEFILGDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKTVREVAGTPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           +V+IGSCT G+ ED  AA KV    GG    +   + PA++ V ++
Sbjct: 298 QVFIGSCTNGRIEDLRAALKVIEKHGGISKDIRVVVTPASRSVMLE 343

[127][TOP]
>UniRef100_P81291 Isopropylmalate/citramalate isomerase large subunit n=1
           Tax=Methanocaldococcus jannaschii RepID=LEUC_METJA
          Length = 424

 Score =  128 bits (322), Expect = 3e-28
 Identities = 66/165 (40%), Positives = 97/165 (58%), Gaps = 5/165 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+ V GATYK+ +F G TV+ +++  RMT+ NM +E GGK G+I PD  T +Y+
Sbjct: 178 ILSIIGEVGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYV 237

Query: 183 EGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T  P+E +  D+ A F   Y  +  K+EP+ A PH+ DN   ARE     I+
Sbjct: 238 KEAMKKHGTERPFEVIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKQAREVAGKPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
           +V+IGSCT G+ ED   A K+    GG    V   + PA+++ ++
Sbjct: 298 QVFIGSCTNGRLEDLRMAIKIIEKHGGIADDVRVVVTPASREEYL 342

[128][TOP]
>UniRef100_C1I927 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium sp.
           7_2_43FAA RepID=C1I927_9CLOT
          Length = 424

 Score =  128 bits (321), Expect = 4e-28
 Identities = 68/162 (41%), Positives = 97/162 (59%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEFVG+ ++ L++++R T+ NM +EAGGKNG+ P D VT +YL
Sbjct: 179 ILHIIGMIGVDGALYRSMEFVGNGLKYLSIDDRFTMANMAIEAGGKNGIFPVDDVTIRYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
                  ++   +D+ A +   Y  D++KL P VA PH PDN     E  +V +++V IG
Sbjct: 239 VDHAQREWKVYEADEDAEYDEVYEIDLSKLRPTVAFPHLPDNTRTIDEVGEVAVDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   A  +      KKVK  V   + P TQK+++
Sbjct: 299 SCTNGRISDLRVARDIL---KNKKVKKGVRCIVFPGTQKIYL 337

[129][TOP]
>UniRef100_Q18AJ2 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile 630 RepID=LEUC_CLOD6
          Length = 425

 Score =  128 bits (321), Expect = 4e-28
 Identities = 74/168 (44%), Positives = 100/168 (59%), Gaps = 7/168 (4%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGEI V GA YKSMEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+
Sbjct: 179 ILHIIGEIGVDGALYKSMEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYI 238

Query: 183 EG---KTSVPYESVY-SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKIN 347
                 T     ++Y +D+ A +   Y  D+ KL+  VA PH P+N     E  KD+KI+
Sbjct: 239 NSHKCSTMTKDVNIYEADEDAVYDEVYEIDLAKLKETVAFPHLPENTRTVDEIDKDIKID 298

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           +V IGSCT G+  D    A++     GKKV   V   + P TQKV+++
Sbjct: 299 QVVIGSCTNGRISDLEVVAEIM---KGKKVADGVRVMIFPGTQKVYLE 343

[130][TOP]
>UniRef100_B4WHZ3 3-isopropylmalate dehydratase, large subunit subfamily n=1
           Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ3_9SYNE
          Length = 567

 Score =  127 bits (320), Expect = 5e-28
 Identities = 72/160 (45%), Positives = 97/160 (60%), Gaps = 2/160 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L I+G+I   GAT   +EF GS VE L M+ERMTL NMV+E G   G++P D  T +Y+
Sbjct: 328 MLFILGQIGCHGATGTVVEFAGSVVEQLPMDERMTLANMVIECGAMCGLMPVDQTTREYV 387

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  T+ P+  V +D  A++   YRFD+++L P VA P +PD      E   V I R +IG
Sbjct: 388 KAHTNQPFTEVTADLDAQYEQSYRFDLSQLTPQVAAPPTPDRVVPVHELDGVAITRAFIG 447

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKV 476
           SCTGGK  D  AAA    A  G++V   V  F+VPA+Q V
Sbjct: 448 SCTGGKLHDLAAAA---AAIKGQRVNPAVSLFVVPASQAV 484

[131][TOP]
>UniRef100_A6NUW5 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6NUW5_9BACE
          Length = 422

 Score =  127 bits (320), Expect = 5e-28
 Identities = 74/194 (38%), Positives = 109/194 (56%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IG+I V GA YKS+EF G  V+ L M++R T+ NM +EAGGKNG+ P D VT  YL
Sbjct: 179 MLHLIGQIGVDGALYKSLEFGGEGVKELAMDDRFTISNMAIEAGGKNGIFPVDDVTRAYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+ +  +E+  +D  A +  E   D+ +L P VA PH P N     + + + I +V IG
Sbjct: 239 NGRVTREWEAFEADPDAVYEREVVIDLDQLRPTVALPHLPSNTRTVDQVEGMPIQQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ +D   AA++     G+KV   V   + PATQ++ +D  +            Q 
Sbjct: 299 SCTNGRLKDIKEAAEIL---KGRKVAKGVRCIVFPATQQIMLDAMAAGY--------IQT 347

Query: 537 FEEAGCDTPASPSC 578
             EAGC   ++P+C
Sbjct: 348 LVEAGC-AVSTPTC 360

[132][TOP]
>UniRef100_C9RGT8 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           vulcanius M7 RepID=C9RGT8_9EURY
          Length = 422

 Score =  127 bits (320), Expect = 5e-28
 Identities = 65/165 (39%), Positives = 98/165 (59%), Gaps = 5/165 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+ V GATYK+ +F G TV+++++  RMT+ NM +E GGK G+I PD  T +Y+
Sbjct: 176 ILSIIGEVGVDGATYKACQFGGETVKNMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYV 235

Query: 183 EGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T  P+E +  D+ A F   Y  +  K+EP+ A PH+ DN   ARE     I+
Sbjct: 236 KEAMKKHGTERPFEIIKGDEDAEFEEVYEIEADKIEPVFACPHNVDNVKQAREVAGRPID 295

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
           +V+IGSCT G+ ED   A +V    GG    +   + PA+++ ++
Sbjct: 296 QVFIGSCTNGRVEDLRMAIEVIEKHGGIADNIRVIITPASREEYL 340

[133][TOP]
>UniRef100_C7MMM0 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Cryptobacterium curtum DSM 15641 RepID=C7MMM0_CRYCD
          Length = 423

 Score =  127 bits (319), Expect = 6e-28
 Identities = 76/194 (39%), Positives = 104/194 (53%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y++MEF G  +E L++E RMT+ NM +EAGGK G+ P D+ T  YL
Sbjct: 182 ILHIIGRIGVDGALYQAMEFHGGAIEGLSIEGRMTMANMAIEAGGKAGLFPVDTTTRAYL 241

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +T  PY     D+ A +      D   + P VA PH P N     E +DV I++  IG
Sbjct: 242 DARTERPYTVYNPDEGAVYARTITIDAADIVPTVAFPHLPSNTRPVAEARDVAIDQAVIG 301

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED  AAA V     G+ V  +V   ++PATQ V+             +  + I
Sbjct: 302 SCTNGRIEDMRAAAHVL---NGRTVHPRVRCIVIPATQAVFKQCID--------EGLTDI 350

Query: 537 FEEAGCDTPASPSC 578
           F  A C   ++P+C
Sbjct: 351 FVNAHC-VVSTPTC 363

[134][TOP]
>UniRef100_B0A9M7 Putative uncharacterized protein n=1 Tax=Clostridium bartlettii DSM
           16795 RepID=B0A9M7_9CLOT
          Length = 429

 Score =  127 bits (319), Expect = 6e-28
 Identities = 78/199 (39%), Positives = 109/199 (54%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGEI V GA Y SMEF G  V+ L+M++R T+CNM +EAG KNG+ P D  T +Y+
Sbjct: 179 ILHIIGEIGVDGARYMSMEFAGDGVQYLSMDDRFTICNMAIEAGAKNGIFPVDEKTKEYM 238

Query: 183 EG---KTSVPYESVY-SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE-CKDVKIN 347
           E    KT     +VY +D+ A +      D+++L+P VA PH P+N     E  +D+KI+
Sbjct: 239 EAHPCKTIEKNPTVYEADEDAEYDRVIEIDLSELKPTVAFPHLPENTKTTDEITEDIKID 298

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGK 521
           +V IGSCT G+ ED   AA++     GKKV   V   + P TQ ++++          G 
Sbjct: 299 QVVIGSCTNGRIEDMRIAAEIM---RGKKVADDVRCIVFPGTQAIYLEAI------EKGY 349

Query: 522 TCSQIFEEAGCDTPASPSC 578
               +   A   TP    C
Sbjct: 350 ITDMVLAGAAISTPTCGPC 368

[135][TOP]
>UniRef100_A6DDD6 3-ISOPROPYLMALATE DEHYDRATASE, LARGE SUBUNIT n=1 Tax=Caminibacter
           mediatlanticus TB-2 RepID=A6DDD6_9PROT
          Length = 425

 Score =  127 bits (319), Expect = 6e-28
 Identities = 73/168 (43%), Positives = 102/168 (60%), Gaps = 9/168 (5%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I  I V GA YK++EF G T+E+L M++RM+LCNMV+EAG KNG+I  D +T  +L
Sbjct: 178 ILELIRRIGVDGALYKALEFTGDTIENLPMDDRMSLCNMVIEAGAKNGIIAYDKITESFL 237

Query: 183 EG-KTSVPYESV----YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVK 341
           E  K   P  S     YSD  A+++     DV  LEP+VA P+ P N     E    D++
Sbjct: 238 EEVKKHNPLRSTPKIHYSDPDAKYVKIIEIDVDNLEPMVAYPYLPSNGKPISEAVKDDIE 297

Query: 342 INRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           I++VYIGSCT G   D   AA +     GK+V  +V   + PATQ+++
Sbjct: 298 IHQVYIGSCTNGTLSDLRTAANIL---KGKRVHKRVRLIVTPATQRIY 342

[136][TOP]
>UniRef100_A5KNQ3 Putative uncharacterized protein n=1 Tax=Ruminococcus torques ATCC
           27756 RepID=A5KNQ3_9FIRM
          Length = 451

 Score =  127 bits (319), Expect = 6e-28
 Identities = 76/197 (38%), Positives = 106/197 (53%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG+I V GA YKSMEF G  + +L+M++R T+ NM +EAG KNG+ P D  T +YL
Sbjct: 185 IIHIIGKIGVDGALYKSMEFTGDGIGNLSMDDRFTMANMAIEAGAKNGIFPVDEKTVEYL 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC---KDVKINRV 353
           +     PY    +D+ A +      D++K+ P VA PH P N     E    + VKI++V
Sbjct: 245 DAHCEKPYTVYEADEDAVYDDVVEIDLSKVRPTVAFPHLPGNAKTIDEIEAEEQVKIDQV 304

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
            IGSCT G+ ED   AA + L        V   +VPATQK++             +    
Sbjct: 305 VIGSCTNGRMEDMRKAAAI-LKGHTVHPDVRVMVVPATQKIYKQCIK--------EGLLD 355

Query: 534 IFEEAGC--DTPASPSC 578
           IF +AGC  +TP+   C
Sbjct: 356 IFVDAGCAVNTPSCGPC 372

[137][TOP]
>UniRef100_A6UTQ6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           aeolicus Nankai-3 RepID=A6UTQ6_META3
          Length = 425

 Score =  127 bits (319), Expect = 6e-28
 Identities = 74/197 (37%), Positives = 109/197 (55%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIGE+   GATYK+ ++ G TVE +++  RMT+ NM +E G K G+I PD  T  ++
Sbjct: 179 ILKIIGEVGFDGATYKAAQYGGETVEEMSISSRMTMSNMAIEMGAKAGLIEPDVKTTYFI 238

Query: 183 EGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T+ PY ++  D+ A+F   Y  +V  LEPL A PH+ DN   ARE     I+
Sbjct: 239 KRAMQKHGTTRPYTALKGDEDAKFEETYEIEVNDLEPLFACPHAVDNVKTAREVAGRPID 298

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           +V+IGSCT G+ ED  AA  +    GG    V   + PA+++V ++  +        +  
Sbjct: 299 QVFIGSCTNGRVEDLRAAINIIDQHGGIADDVRVVVTPASREVMLEAIN--------EGI 350

Query: 528 SQIFEEAGCDTPASPSC 578
            Q F E GC    +PSC
Sbjct: 351 IQKFYEYGC-VVTNPSC 366

[138][TOP]
>UniRef100_A5FS15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FS15_DEHSB
          Length = 431

 Score =  127 bits (318), Expect = 8e-28
 Identities = 65/166 (39%), Positives = 100/166 (60%), Gaps = 1/166 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I   GATYK++EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL
Sbjct: 189 ILHLIGLIGADGATYKALEFSGNVVNNMTVAERLTIANMAVEAGAKVGLFPSDRQTLEYL 248

Query: 183 EGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
                   Y+ + +D  A +      D T LEP ++KPH+ DN A ARE K  K+++V+I
Sbjct: 249 RSVGREADYQPLAADADAVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFI 308

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSL 497
           G+CTGG+ +D   AA +F  +  +  +    + PA+QK++++   L
Sbjct: 309 GTCTGGRLDDLAVAAAIF-KNRKRHPQTRLIVTPASQKIYLEAIRL 353

[139][TOP]
>UniRef100_Q1Q122 Similar to 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q122_9BACT
          Length = 437

 Score =  127 bits (318), Expect = 8e-28
 Identities = 63/161 (39%), Positives = 96/161 (59%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YK+MEF G+ +  L M++R T+CNM +EAG K+G+I PD +T  Y+
Sbjct: 186 ILYTIGKIGVDGALYKAMEFTGTAISDLPMDDRFTICNMAIEAGAKSGIIAPDKITENYV 245

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+    Y + +SD  + +   Y F+  ++ P VA P  P+N     +   +KI++V IG
Sbjct: 246 AGRVKREYVAYHSDPDSHYSKVYEFNAEEIVPQVALPSLPENTKSVYDVCGIKIDQVVIG 305

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+  D   AAK+     GKK    +   ++PATQ+++
Sbjct: 306 SCTNGRISDLRIAAKIL---KGKKAHPSLRLIIIPATQEIY 343

[140][TOP]
>UniRef100_A8CU07 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           VS RepID=A8CU07_9CHLR
          Length = 417

 Score =  127 bits (318), Expect = 8e-28
 Identities = 67/166 (40%), Positives = 100/166 (60%), Gaps = 1/166 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I   GATYK++EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL
Sbjct: 175 ILHLIGLIGADGATYKALEFSGNVVNNMMIAERLTIANMAVEAGAKVGLFPSDRQTLEYL 234

Query: 183 EGK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
                   Y+ + +D+ A +      D T LEP V+KPH+ DN A ARE K  K+++V+I
Sbjct: 235 RSVGREADYQPLAADENAVYERVIEIDATALEPTVSKPHTVDNTATARELKGTKLDQVFI 294

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSL 497
           G+CTGG+ +D   AA +F  +     +    + PA+QKV+++   L
Sbjct: 295 GTCTGGRLDDLAVAAAIF-KNRRHHPQTRLIVTPASQKVYLEAIRL 339

[141][TOP]
>UniRef100_B8FMM4 3-isopropylmalate dehydratase large subunit n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=LEUC_DESAA
          Length = 419

 Score =  127 bits (318), Expect = 8e-28
 Identities = 65/159 (40%), Positives = 96/159 (60%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y +MEF G  +++L M ER+T+ NM +EAGGK G+I PD+ T +Y 
Sbjct: 179 ILHTIGDIGVDGALYMAMEFTGEVIDALPMAERLTMANMAIEAGGKAGIIAPDAKTKEYA 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+         SD  A++     +DVT LEP VA PH P+N     +  +V I++V IG
Sbjct: 239 DGRVIRKPVFYASDPDAKYAKVIEYDVTDLEPQVAFPHLPENTRPISQVGEVPIHQVIIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVW 479
           SCT G+ ED  +AA++   +   K  V   ++PAT +++
Sbjct: 299 SCTNGRIEDMRSAARILTGNKADK-NVRLIIIPATPQIY 336

[142][TOP]
>UniRef100_Q8U2A1 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           furiosus RepID=LEUC1_PYRFU
          Length = 424

 Score =  127 bits (318), Expect = 8e-28
 Identities = 69/163 (42%), Positives = 103/163 (63%), Gaps = 4/163 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YK MEF G  +E L++E+RMT+ NM +EAG K G+I PD  T +Y+
Sbjct: 180 ILYTIGDIGVNGALYKVMEFSGEVIEKLSVEQRMTMTNMAIEAGAKTGIIEPDKKTIEYV 239

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRA-LARECK-DVKINRVY 356
           +G+    Y+   SD+ A++     +DV+K+EP VA PH P+N   +++  K ++KI++V 
Sbjct: 240 KGRAKREYKIYKSDEDAKYYKVIEYDVSKIEPQVAFPHLPENTVPISKAAKMNIKIDQVV 299

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVW 479
           IGSCT G+ ED   AA+V     G+KV   V   ++P +  V+
Sbjct: 300 IGSCTNGRLEDLRMAAEVL---EGQKVAPWVRLIILPCSPTVY 339

[143][TOP]
>UniRef100_C4FI11 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium yellowstonense SS-5
           RepID=C4FI11_9AQUI
          Length = 431

 Score =  126 bits (317), Expect = 1e-27
 Identities = 67/186 (36%), Positives = 108/186 (58%), Gaps = 2/186 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IG+I V GA YK+ME+ G  +++L+++ R+T+ NM +EAGGK+G+I PD  T +++
Sbjct: 179 VLTVIGKIGVDGALYKAMEYHGEAIKALDIDNRLTIANMAIEAGGKSGIIEPDEKTVEWV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T   ++   SD  A++  EY FD +K+EP+VA P  P N     E     I++V+IG
Sbjct: 239 RKRTDREFKLYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTHIDQVFIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AA +     GKKV  +V   ++PA+ +++             +   +I
Sbjct: 299 SCTNGRLSDLRIAAAIL---KGKKVHPEVRCIVIPASDQIYKQALH--------EGIIEI 347

Query: 537 FEEAGC 554
             EAGC
Sbjct: 348 LAEAGC 353

[144][TOP]
>UniRef100_B9D2G7 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           rectus RM3267 RepID=B9D2G7_WOLRE
          Length = 424

 Score =  126 bits (317), Expect = 1e-27
 Identities = 75/197 (38%), Positives = 113/197 (57%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II  I V GA YK++EF G T+E+L+M+ R ++CNM +EAGGK+G+I  D  T ++L
Sbjct: 181 ILEIIRHIGVDGALYKALEFTGETIENLDMDGRFSMCNMAIEAGGKSGIIAVDETTKEFL 240

Query: 183 EGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRV 353
           +GK       + YSD+ A +    + DV+KL+P++A P  P N    RE    D+ I++ 
Sbjct: 241 KGKNLRAEPKLHYSDEGANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVKDDIAIDQA 300

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           +IGSCT G+  D   AA++     G+KV  K    + PATQK+ +            +  
Sbjct: 301 FIGSCTNGRLSDLRIAAEIL---KGRKVARKTRLIITPATQKIALQAQK--------EGL 349

Query: 528 SQIFEEAGCDTPASPSC 578
             IF EAG    ++P+C
Sbjct: 350 MDIFAEAGA-VVSNPTC 365

[145][TOP]
>UniRef100_A9AAG0 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           maripaludis C6 RepID=A9AAG0_METM6
          Length = 424

 Score =  126 bits (317), Expect = 1e-27
 Identities = 63/166 (37%), Positives = 97/166 (58%), Gaps = 5/166 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +   GATYK+ +F G+TV+++ +  RM++ NM +E GGK G+I PD  T  Y+
Sbjct: 178 ILSIIGMVGADGATYKAAQFAGNTVDNMTIASRMSMSNMAIEMGGKAGLIAPDDKTINYV 237

Query: 183 EG-----KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T+ P+E +  D+ A F  ++  +V  LEP++A PH+ DN    RE     I+
Sbjct: 238 KNAMETNNTAKPFEFILGDKNAEFEEKFEIEVDNLEPVMACPHNVDNVKAVREVAGTPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           +V+IGSCT G+ ED  AA  V    GG    +   + PA++ V ++
Sbjct: 298 QVFIGSCTNGRIEDLRAALNVIEKHGGISKDIRVVVTPASRSVMLE 343

[146][TOP]
>UniRef100_B1H0A6 3-isopropylmalate dehydratase large subunit n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=LEUC_UNCTG
          Length = 420

 Score =  126 bits (317), Expect = 1e-27
 Identities = 68/161 (42%), Positives = 93/161 (57%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y SMEF G   + L M +R T+ NM +EAGGKNG+  PD +T  Y+
Sbjct: 179 ILYIIGLIGVDGALYNSMEFDGPLCKKLTMADRFTITNMAIEAGGKNGIFTPDEITENYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y+   SD+ A++L  Y  D +K+ P V+ P  P N    ++ K   I++V IG
Sbjct: 239 AKRAQRKYKFYISDKDAKYLKIYEIDCSKILPQVSMPFLPSNTKAVKDIKKTYIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA +     GKKV   V T ++PAT +V+
Sbjct: 299 SCTNGRIEDLRVAASII--KKGKKVNSNVRTLIIPATPEVY 337

[147][TOP]
>UniRef100_O27668 3-isopropylmalate dehydratase large subunit 2 n=1
           Tax=Methanothermobacter thermautotrophicus str. Delta H
           RepID=LEUC2_METTH
          Length = 428

 Score =  126 bits (317), Expect = 1e-27
 Identities = 65/162 (40%), Positives = 100/162 (61%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGEI V GATY+S+EF G T+ES+++  RMT+CNM VE G KNG++ P+  T  Y+
Sbjct: 183 ILHIIGEIGVDGATYRSVEFTGDTIESMDVSGRMTICNMAVEMGAKNGIMEPNRQTLDYV 242

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T   +    SD+ +++L ++ FDV+ LEP VA P   DN       +   I+  ++G
Sbjct: 243 RARTGREFRVYSSDEDSQYLEDHHFDVSDLEPQVACPDDVDNVYPVHRVEGTHIDEAFLG 302

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SCT G+ ED   AA+V    G ++V   V   + PA++++++
Sbjct: 303 SCTNGRYEDLKIAAEVI---GDRRVHEDVRFIVSPASREIYL 341

[148][TOP]
>UniRef100_UPI00016C5FE1 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           difficile QCD-97b34 RepID=UPI00016C5FE1
          Length = 425

 Score =  126 bits (316), Expect = 1e-27
 Identities = 73/168 (43%), Positives = 100/168 (59%), Gaps = 7/168 (4%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGEI V GA YKSMEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+
Sbjct: 179 ILHIIGEIGVDGALYKSMEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYI 238

Query: 183 EG---KTSVPYESVY-SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKIN 347
                 T     ++Y +D+ A +   Y  D+ +L+  VA PH P+N     E  KD+KI+
Sbjct: 239 NSHKCSTITKDVNIYEADEDAVYDEVYEIDLAELKETVAFPHLPENTRTVDEIDKDIKID 298

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           +V IGSCT G+  D    A++     GKKV   V   + P TQKV+++
Sbjct: 299 QVVIGSCTNGRISDLEVVAEIM---KGKKVADGVRVMIFPGTQKVYLE 343

[149][TOP]
>UniRef100_C0QS35 3-isopropylmalate dehydratase, large subunit n=1 Tax=Persephonella
           marina EX-H1 RepID=C0QS35_PERMH
          Length = 428

 Score =  126 bits (316), Expect = 1e-27
 Identities = 62/161 (38%), Positives = 99/161 (61%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IGEI V GA Y++ME+ G  +++L++E R+T+ NM +EAGGKN ++  D    ++L
Sbjct: 179 VLTVIGEIGVDGALYRAMEYHGEAIQALDVENRLTIANMAIEAGGKNAIMEADEKVLEWL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + KT  P   + +D  A++  EY FD +K+EP+VA P+ P N     E     IN+V+IG
Sbjct: 239 KDKTDRPLRMLKADPDAKYCCEYEFDASKIEPVVAAPNLPSNVKPVTEVAGKPINQVFIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+  D   AA +     G+KV   V   ++PA+ +++
Sbjct: 299 SCTNGRMSDLRIAAHIL---KGRKVHPDVRCIVIPASDRIY 336

[150][TOP]
>UniRef100_A9BGP4 3-isopropylmalate dehydratase, large subunit n=1 Tax=Petrotoga
           mobilis SJ95 RepID=A9BGP4_PETMO
          Length = 419

 Score =  126 bits (316), Expect = 1e-27
 Identities = 77/194 (39%), Positives = 105/194 (54%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YKS+EF G T+E L+M+ RMT+ NM +EAG K G+   D  T +YL
Sbjct: 177 ILYTIGDIGVDGALYKSIEFTGETIEDLSMDSRMTMANMAIEAGAKCGLFEYDEKTKEYL 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +    Y  V SD  A +     +DV+ +EP VA PH P+N     E K +KI++  IG
Sbjct: 237 KERAVRDYTPVSSDPDASYEEVIEYDVSNIEPQVAFPHLPENTKPVTEAKRIKIDQSVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+ ED   AA V     G KV   V   + P TQ ++M            +   +I
Sbjct: 297 SCTNGRIEDLRIAAHVL---KGHKVNSDVRCIIFPGTQDIYMQALK--------EGLIEI 345

Query: 537 FEEAGCDTPASPSC 578
           F EAG    ++P+C
Sbjct: 346 FIEAGA-AVSTPTC 358

[151][TOP]
>UniRef100_C9XME3 3-isopropylmalate dehydratase large subunit n=2 Tax=Clostridium
           difficile RepID=C9XME3_CLODI
          Length = 364

 Score =  126 bits (316), Expect = 1e-27
 Identities = 73/168 (43%), Positives = 100/168 (59%), Gaps = 7/168 (4%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGEI V GA YKSMEF G  VE L+M++R T+CNM +EAG KNG+ P D  T +Y+
Sbjct: 118 ILHIIGEIGVDGALYKSMEFCGDGVEYLSMDDRFTICNMAIEAGAKNGIFPVDDKTMEYI 177

Query: 183 EG---KTSVPYESVY-SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKIN 347
                 T     ++Y +D+ A +   Y  D+ +L+  VA PH P+N     E  KD+KI+
Sbjct: 178 NSHKCSTITKDVNIYEADEDAVYDEVYEIDLAELKETVAFPHLPENTRTVDEIDKDIKID 237

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           +V IGSCT G+  D    A++     GKKV   V   + P TQKV+++
Sbjct: 238 QVVIGSCTNGRISDLEVVAEIM---KGKKVADGVRVMIFPGTQKVYLE 282

[152][TOP]
>UniRef100_C6RH21 3-isopropylmalate dehydratase, large subunit n=1 Tax=Campylobacter
           showae RM3277 RepID=C6RH21_9PROT
          Length = 424

 Score =  126 bits (316), Expect = 1e-27
 Identities = 75/197 (38%), Positives = 112/197 (56%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II  I V GA YK++EF G T+E+L+M+ R ++CNM +EAGGK+G+I  D  T ++L
Sbjct: 181 ILEIIRRIGVDGALYKALEFTGETIENLDMDGRFSMCNMAIEAGGKSGIIAVDETTKEFL 240

Query: 183 EGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRV 353
           +GK       + YSD+ A +      DV+KL+P++A P  P N    RE    D+ I++ 
Sbjct: 241 KGKNLRAEPKLHYSDEGANYEQILEIDVSKLDPVIAYPFLPSNGKSVREAVRDDIAIDQA 300

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           +IGSCT G+  D   AA++     G+KV  K    + PATQK+ +            +  
Sbjct: 301 FIGSCTNGRLSDLRIAAEIL---KGRKVARKTRLIITPATQKIALQAQK--------EGL 349

Query: 528 SQIFEEAGCDTPASPSC 578
             IF EAG    ++P+C
Sbjct: 350 MDIFAEAGA-VVSNPTC 365

[153][TOP]
>UniRef100_C4GAI7 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4GAI7_9FIRM
          Length = 434

 Score =  126 bits (316), Expect = 1e-27
 Identities = 65/163 (39%), Positives = 100/163 (61%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEF G  ++ L+M++R T+ NM +E G KNG+ P D  T  Y+
Sbjct: 193 ILHIIGLIGVDGARYQSMEFDGEGIQYLSMDDRFTIANMAIEGGAKNGIFPVDDQTLAYI 252

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +           +D  A + +EY  D++ L+P V+ PH P+N     + +D+ I++V IG
Sbjct: 253 KEHADRKPLVYEADADADYAAEYTIDLSSLKPTVSFPHLPENTRTIDQIEDIAIDQVVIG 312

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D  AAA++     G+KV  +V T ++PATQ++++D
Sbjct: 313 SCTNGRLSDLKAAAEIL---KGRKVADRVRTIIIPATQQIYLD 352

[154][TOP]
>UniRef100_A5ZNE1 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC
           29174 RepID=A5ZNE1_9FIRM
          Length = 416

 Score =  126 bits (316), Expect = 1e-27
 Identities = 66/161 (40%), Positives = 95/161 (59%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+   G  Y+ MEF G   ++L++ +RMTLCNM VEAG K G+   D    +YL
Sbjct: 176 ILTIIGEVGANGCNYQVMEFTGEGAKTLSISDRMTLCNMAVEAGAKTGIFEADEKAMEYL 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +     P    +SD  A+++ EY FD++K+ P+VAKP   DN   A E   ++IN  ++G
Sbjct: 236 KEHGREPKAVFHSDPDAKYVREYTFDLSKVRPVVAKPDFVDNVVPAEEACGIEINEAFLG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SC  G+ ED    A++     GKKV  KV   +VPA+Q ++
Sbjct: 296 SCNNGRIEDLRVGAEII---KGKKVSDKVRFLVVPASQTIY 333

[155][TOP]
>UniRef100_Q7M9Z9 3-isopropylmalate dehydratase large subunit n=1 Tax=Wolinella
           succinogenes RepID=LEUC_WOLSU
          Length = 422

 Score =  126 bits (316), Expect = 1e-27
 Identities = 69/169 (40%), Positives = 107/169 (63%), Gaps = 6/169 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II +I V GA YK++EF G T+E L+M++R +LCNM +EAG KNG+I  DS+T ++L
Sbjct: 178 ILEIIRQIGVDGALYKALEFQGDTIEQLSMDDRFSLCNMAIEAGAKNGIIAADSITKEFL 237

Query: 183 EGKTSVPYESVY--SDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINR 350
             + S+  E  Y  +D  A +      DV KLEP++A P  P N +++++  K D+KI++
Sbjct: 238 ASRKSLRAEPKYYQADADALYEQTIEIDVEKLEPVIAYPFLPSNGKSISQAVKDDLKIDQ 297

Query: 351 VYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVY 491
            +IGSCT G+  D   AA++     GK+V   V   + P TQ+++ D +
Sbjct: 298 AFIGSCTNGRLSDLRIAAQIL---KGKRVHPDVRLIITPGTQQIYKDAH 343

[156][TOP]
>UniRef100_UPI000196B289 hypothetical protein CATMIT_00953 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196B289
          Length = 425

 Score =  125 bits (315), Expect = 2e-27
 Identities = 77/199 (38%), Positives = 106/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  V+ L+M +R T+CNM +EAG KNG+ P D    +YL
Sbjct: 178 ILHIIGRIGVDGALYKSMEFTGEGVKELSMADRFTICNMAIEAGAKNGIFPVDEAAIEYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK---DVKINRV 353
           +      Y+   +D+ A +      D++ + P VA PH P N     E +    + I++V
Sbjct: 238 DKHAKRDYKIYEADKDAEYEEIVDVDLSAIRPTVAFPHLPGNAKTVDEIEAMDKIYIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+ ED   AA +     GKKV   V   +VPATQK+++            +  
Sbjct: 298 VIGSCTNGRMEDLRKAAAIL---KGKKVADNVRVMVVPATQKIYLQCIL--------EGI 346

Query: 528 SQIFEEAGC--DTPASPSC 578
            + F EAGC  +TP+   C
Sbjct: 347 LETFVEAGCAVNTPSCGPC 365

[157][TOP]
>UniRef100_C7P7J9 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           fervens AG86 RepID=C7P7J9_METFA
          Length = 424

 Score =  125 bits (315), Expect = 2e-27
 Identities = 65/165 (39%), Positives = 97/165 (58%), Gaps = 5/165 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+ V GATYK+ +F G TV+ +++  RMT+ NM +E GGK G+I PD  T +Y+
Sbjct: 178 ILSIIGEVGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTVQYV 237

Query: 183 EGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T  P+E +  D+ A F   Y  +  K+EP+ A PH+ DN   ARE     I+
Sbjct: 238 KEAMKKHGTERPFEIIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKPAREVAGRPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
           +V+IGSCT G+ ED   A ++    GG    V   + PA+++ ++
Sbjct: 298 QVFIGSCTNGRFEDLKMAIEIIDKHGGIADNVRVVVTPASREEYL 342

[158][TOP]
>UniRef100_Q3ZZK0 Homoaconitate hydratase family protein n=1 Tax=Dehalococcoides sp.
           CBDB1 RepID=Q3ZZK0_DEHSC
          Length = 417

 Score =  125 bits (314), Expect = 2e-27
 Identities = 65/166 (39%), Positives = 100/166 (60%), Gaps = 1/166 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I   GATYK++EF G+ V ++ + ER+T+ NM VEAG K G+ P D  T +YL
Sbjct: 175 ILHLIGLIGADGATYKALEFSGNVVNNMTVAERLTIANMAVEAGAKVGLFPSDRQTLEYL 234

Query: 183 -EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
                   Y+ + +D  A +      D T LEP ++KPH+ DN A ARE K  K+++V+I
Sbjct: 235 CSVGREADYQPLAADVDAVYERVIEIDATALEPTISKPHTVDNTATARELKGTKLDQVFI 294

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSL 497
           G+CTGG+ +D   AA +F  +  +  +    + PA+QK++++   L
Sbjct: 295 GTCTGGRLDDLAVAAAIF-KNRKRHPQTRLIVTPASQKIYLEAIRL 339

[159][TOP]
>UniRef100_C3RJS7 Putative uncharacterized protein n=1 Tax=Mollicutes bacterium D7
           RepID=C3RJS7_9MOLU
          Length = 422

 Score =  125 bits (314), Expect = 2e-27
 Identities = 77/199 (38%), Positives = 107/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL II  I V GA YKSMEFVG  ++ L M++R T+CNM +EAG KNG+ P D  T  Y+
Sbjct: 176 ILDIITRIGVDGARYKSMEFVGEGIQHLTMDDRFTICNMAIEAGAKNGIFPVDEQTIAYM 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK---DVKINRV 353
           E  +   Y    +D+ A +      D+ K+ P VA PH P N     E +    + I++V
Sbjct: 236 EKHSVKEYAVYEADEDAEYDEVIEIDLGKVRPTVAFPHLPGNGHTIDEIEAMDKIMIDQV 295

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+  D   AA +     GK+V   V   +VPATQK+++            +  
Sbjct: 296 VIGSCTNGRLSDLRKAAAIL---KGKQVAKNVRVMVVPATQKIFVQCIH--------EGL 344

Query: 528 SQIFEEAGC--DTPASPSC 578
           ++IF EAGC  +TP+   C
Sbjct: 345 AEIFVEAGCAFNTPSCGPC 363

[160][TOP]
>UniRef100_B0N943 Putative uncharacterized protein n=1 Tax=Clostridium ramosum DSM
           1402 RepID=B0N943_9FIRM
          Length = 424

 Score =  125 bits (314), Expect = 2e-27
 Identities = 77/199 (38%), Positives = 107/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL II  I V GA YKSMEFVG  ++ L M++R T+CNM +EAG KNG+ P D  T  Y+
Sbjct: 178 ILDIITRIGVDGARYKSMEFVGEGIQHLTMDDRFTICNMAIEAGAKNGIFPVDEQTIAYM 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK---DVKINRV 353
           E  +   Y    +D+ A +      D+ K+ P VA PH P N     E +    + I++V
Sbjct: 238 EKHSVKEYAVYEADEDAEYDEVIEIDLGKVRPTVAFPHLPGNGHTIDEIEAMDKIMIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+  D   AA +     GK+V   V   +VPATQK+++            +  
Sbjct: 298 VIGSCTNGRLSDLRKAAAIL---KGKQVAKNVRVMVVPATQKIFVQCIH--------EGL 346

Query: 528 SQIFEEAGC--DTPASPSC 578
           ++IF EAGC  +TP+   C
Sbjct: 347 AEIFVEAGCAFNTPSCGPC 365

[161][TOP]
>UniRef100_A6BFK8 Putative uncharacterized protein n=1 Tax=Dorea longicatena DSM
           13814 RepID=A6BFK8_9FIRM
          Length = 424

 Score =  125 bits (314), Expect = 2e-27
 Identities = 75/197 (38%), Positives = 108/197 (54%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG+I V GA YKSMEF G  +++L+M +R T+ NM +EAG KNG+ P D  T +YL
Sbjct: 178 IIHIIGKIGVDGALYKSMEFTGDGIKNLSMADRFTMANMAIEAGAKNGIFPVDEKTEEYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
           +  T   Y+   +D  A + S    D++++ P VA PH P N     E    + +KI++V
Sbjct: 238 KEHTKKEYKVYEADGDAEYESVVEIDLSEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
            IGSCT G+ ED   AA + L        V   +VPATQK++             +   +
Sbjct: 298 VIGSCTNGRMEDMRKAAAI-LQGHTVHPDVRVMVVPATQKIYKQCIR--------EGLLE 348

Query: 534 IFEEAGC--DTPASPSC 578
           IF +AGC  +TP+   C
Sbjct: 349 IFVDAGCAVNTPSCGPC 365

[162][TOP]
>UniRef100_A1HLS2 3-isopropylmalate dehydratase, large subunit n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HLS2_9FIRM
          Length = 420

 Score =  125 bits (314), Expect = 2e-27
 Identities = 65/163 (39%), Positives = 98/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IG I V GA Y+S+EF G  V +L M +R+T+ NM +EAG KNG+ P D  T +YL
Sbjct: 178 VLTLIGMIGVDGARYQSLEFCGEGVAALTMADRLTIANMAIEAGAKNGIFPVDDATIRYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    YE+V  D  A ++     ++  LEP+VA PH P+N   A + +D+ I++V IG
Sbjct: 238 STRVERDYEAVSPDADASYVRTVVINLDDLEPVVALPHLPENVRPAAQVRDIAIDQVVIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+ ED   AA +     GK V  +V   ++P +Q V+++
Sbjct: 298 SCTNGRLEDLAQAAAIL---EGKTVHPRVRAIVIPGSQAVYLE 337

[163][TOP]
>UniRef100_A6Q5L6 3-isopropylmalate dehydratase large subunit n=1 Tax=Nitratiruptor
           sp. SB155-2 RepID=LEUC_NITSB
          Length = 421

 Score =  125 bits (314), Expect = 2e-27
 Identities = 70/163 (42%), Positives = 101/163 (61%), Gaps = 5/163 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I  I V GA YK++EF G T+E+L+M+ R +LCNM +EAG KNG+I  D VT  +L
Sbjct: 178 ILELIRRIGVDGALYKALEFTGDTIENLDMDGRFSLCNMAIEAGAKNGIIAVDEVTKAFL 237

Query: 183 EGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINRV 353
             K       + YSD+ A +      DV  LEP++A PH P N R ++   K D+K+++V
Sbjct: 238 ADKPLAREPKIHYSDEDAEYEQVIEIDVNNLEPVIAFPHLPSNGRPISEAAKMDLKVDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKV 476
           +IGSCT G+  D   AA++     G+KV   T ++  PATQK+
Sbjct: 298 FIGSCTNGRLSDIAIAAEIL---KGRKVARHTRMIVTPATQKI 337

[164][TOP]
>UniRef100_A7IA28 3-isopropylmalate dehydratase large subunit n=1 Tax=Candidatus
           Methanoregula boonei 6A8 RepID=LEUC_METB6
          Length = 416

 Score =  125 bits (314), Expect = 2e-27
 Identities = 63/162 (38%), Positives = 100/162 (61%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL I  +I   GATY+++EF G T+  ++M  RMT CNM +E G K G++PPD VT++Y+
Sbjct: 176 ILSIAADIGADGATYQAIEFTGKTISKMDMAGRMTCCNMAIEMGAKAGIVPPDKVTWEYM 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+  +   ++ SD  A+F  +  ++V  LEP VA PH+ D      + +   I++V+IG
Sbjct: 236 KGRRKITPFALASDDDAKFAEKRTYNVADLEPQVAVPHNVDQGIPVGKVEGTHIDQVFIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SCT G+ ED + AA+V    G KK   KV   ++PA++  ++
Sbjct: 296 SCTNGRYEDLVEAAEVL---GKKKFDPKVRVLVIPASRDEYL 334

[165][TOP]
>UniRef100_B2UYH6 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum E3 str. Alaska E43 RepID=LEUC_CLOBA
          Length = 419

 Score =  125 bits (314), Expect = 2e-27
 Identities = 67/162 (41%), Positives = 95/162 (58%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDDKTVEYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  T   ++   +D+ A +      D++ L+P V+ PH PDN         V I++V IG
Sbjct: 239 KEHTEKEWKIYEADEDAEYDEVIEIDLSTLKPTVSFPHLPDNTRTIDNANRVNIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   A  +     GKKVK  +   ++P TQK+++
Sbjct: 299 SCTNGRISDLRIARGIL---KGKKVKKGIRCIVIPGTQKIYL 337

[166][TOP]
>UniRef100_Q97EE0 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           acetobutylicum RepID=LEUC_CLOAB
          Length = 422

 Score =  125 bits (314), Expect = 2e-27
 Identities = 63/163 (38%), Positives = 98/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSME+ G  +E L+M++R T+ NM +EAG KNG+ P D  T +Y+
Sbjct: 181 ILHIIGMIGVDGALYKSMEYTGDGLEYLSMDDRFTIANMAIEAGAKNGIFPVDEKTIEYM 240

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G++    +   +D+ A +      D++ L+P VA PH P+N     +  +V +++V IG
Sbjct: 241 KGRSDRELKKFDADEDAEYSRVIEIDLSTLKPTVAFPHLPENTKTIDQVGEVNVDQVVIG 300

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           SCT G+ ED   AA +     GKK+K  +   + P TQ ++++
Sbjct: 301 SCTNGRMEDLRIAASIL---KGKKIKKGIRLIVFPGTQNIYLE 340

[167][TOP]
>UniRef100_A0RMG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           fetus subsp. fetus 82-40 RepID=LEUC_CAMFF
          Length = 421

 Score =  125 bits (314), Expect = 2e-27
 Identities = 80/198 (40%), Positives = 117/198 (59%), Gaps = 6/198 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I +I V GA YK++EF G  ++ L+M+ R +LCNM +EAGGK+G+I  D +T ++L
Sbjct: 178 ILEVIRQIGVDGALYKALEFCGDAMKYLDMDSRFSLCNMAIEAGGKSGIIAVDDITKEFL 237

Query: 183 EGKT--SVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINR 350
           E K   S P +  YSD+ A +    R DV+KL+P++A P  P N     E    D+KI++
Sbjct: 238 ESKNLRSKP-KFHYSDEGANYEQVLRIDVSKLDPVIAYPFLPSNGKSINEALKDDLKIDQ 296

Query: 351 VYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPVPGSGGKT 524
           V+IGSCT G+  D   AA++     GK+V   T L+  PATQK+     +L     G   
Sbjct: 297 VFIGSCTNGRLSDLRIAARIL---KGKRVAKHTRLIITPATQKI-----ALAAQKEG--- 345

Query: 525 CSQIFEEAGCDTPASPSC 578
              IF EAG    ++P+C
Sbjct: 346 LMDIFVEAGA-VVSNPTC 362

[168][TOP]
>UniRef100_B9L0Y1 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0Y1_THERP
          Length = 422

 Score =  125 bits (313), Expect = 3e-27
 Identities = 68/160 (42%), Positives = 96/160 (60%), Gaps = 2/160 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y  MEF G  ++ L M++R+T+ NM +EAG K G+   D  T ++L
Sbjct: 181 ILYTIGQIGVDGALYACMEFTGPVIDQLPMDDRITMANMAIEAGAKTGIFACDDKTREWL 240

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
              T+ PYE V SD  AR+     FDV+ L PLVA PH P N   A E +D+ I++V IG
Sbjct: 241 AKVTTEPYEPVDSDPDARYAQIIEFDVSNLRPLVALPHLPSNVRPADEVRDLPIDQVVIG 300

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKV 476
           SCT G+  D   AA++     G++V  +V   ++P +Q+V
Sbjct: 301 SCTNGRLSDLRIAAEIL---KGRQVHPRVRCIVIPGSQEV 337

[169][TOP]
>UniRef100_C9LTJ0 3-isopropylmalate dehydratase, large subunit n=1 Tax=Selenomonas
           sputigena ATCC 35185 RepID=C9LTJ0_9FIRM
          Length = 420

 Score =  125 bits (313), Expect = 3e-27
 Identities = 73/193 (37%), Positives = 106/193 (54%), Gaps = 1/193 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA YKS+EF G  V +L M +R+T+ NM +EAG KNG+ P D  T +Y+
Sbjct: 178 ILTLIGMIGVDGALYKSLEFTGEGVAALTMTDRLTIANMAIEAGAKNGIFPFDEKTKEYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE-CKDVKINRVYI 359
           EG+    YE V SD  A++      D++ L P+VA PH P N     +  + +KI++V I
Sbjct: 238 EGRVKGAYEPVTSDADAKYCRTVEIDLSSLRPVVAFPHLPGNTKRVMDIAEPIKIDQVVI 297

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIF 539
           GSCT G+ ED   +A + L        V   ++P +Q V+ +   L            +F
Sbjct: 298 GSCTNGRLEDLEISAGL-LKGHEVHPDVRCIVIPGSQAVYQEAMHLGY--------IDVF 348

Query: 540 EEAGCDTPASPSC 578
            +AGC   A+P+C
Sbjct: 349 IDAGC-AVAAPTC 360

[170][TOP]
>UniRef100_B0G7V2 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G7V2_9FIRM
          Length = 425

 Score =  125 bits (313), Expect = 3e-27
 Identities = 75/199 (37%), Positives = 106/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG+I V GA YKSMEF G  + +L+M++R T+ NM +EAG KNG+ P D  T +YL
Sbjct: 178 IIHIIGKIGVDGALYKSMEFTGDGIANLSMDDRFTMANMAIEAGAKNGIFPVDDKTIQYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
              T   Y    +D+ A +      D+ ++ P VA PH P N     E    + +KI++V
Sbjct: 238 NEHTKKEYTVYEADEDAEYEQVVEIDLAEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+ ED   AA +     G KV   V   ++PATQK++             +  
Sbjct: 298 VIGSCTNGRMEDMRKAAAIL---KGHKVHEDVRVMVIPATQKIYKQCIH--------EGL 346

Query: 528 SQIFEEAGC--DTPASPSC 578
             IF +AGC  +TP+   C
Sbjct: 347 MDIFVDAGCAVNTPSCGPC 365

[171][TOP]
>UniRef100_A6UPF6 Homoaconitate hydratase family protein n=1 Tax=Methanococcus
           vannielii SB RepID=A6UPF6_METVS
          Length = 424

 Score =  125 bits (313), Expect = 3e-27
 Identities = 69/197 (35%), Positives = 105/197 (53%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +   GATYK+ +F G TV+ + +  RMT+ NM +E GGK G+I PD  T +Y+
Sbjct: 178 ILSIIGMVGADGATYKAAQFAGETVKEMTIASRMTMSNMAIEMGGKAGLIEPDRKTVEYV 237

Query: 183 E-----GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T+ P++ +  D+ A +  ++  +V  LEP++A PH+ DN    RE     I+
Sbjct: 238 KTAMEKNNTARPFDIIIGDKNAEYEEKFEIEVNDLEPVMACPHNVDNVKTVREVSGTPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           +V+IGSCT G+ ED  AA  V    GG    +   + PA++ V +            +  
Sbjct: 298 QVFIGSCTNGRIEDLRAALNVIEKHGGISKDIRVIVTPASRSVMLKALD--------EGL 349

Query: 528 SQIFEEAGCDTPASPSC 578
            Q F + GC    +PSC
Sbjct: 350 IQKFYKYGC-VVTNPSC 365

[172][TOP]
>UniRef100_Q8TVF2 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Methanopyrus
           kandleri RepID=LEUC1_METKA
          Length = 418

 Score =  125 bits (313), Expect = 3e-27
 Identities = 64/161 (39%), Positives = 99/161 (61%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L++ GEI   GATY ++E+ G  V  +++ +RM LCNM +E G K G++PPD  T +Y+
Sbjct: 177 VLKVTGEIGADGATYMAIEYHGEVVREMSVSDRMCLCNMAIEMGAKTGMVPPDEKTLEYV 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +       V  D  AR+ +E   DV+ LEP VAKP SPDN     E + + I++V+IG
Sbjct: 237 KKRAGTEGRPVEPDPDARYEAELTLDVSDLEPQVAKPFSPDNVVPVGEVEGIAIDQVFIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+ ED   AA+V     G++V   V   ++PA+++V+
Sbjct: 297 SCTNGRYEDLKVAAEVL---EGEEVHDDVRLIVIPASREVY 334

[173][TOP]
>UniRef100_C6BSG9 3-isopropylmalate dehydratase, large subunit n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG9_DESAD
          Length = 419

 Score =  124 bits (312), Expect = 4e-27
 Identities = 66/159 (41%), Positives = 95/159 (59%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V+GA YK++EF GS VE+L++E RMT+ NM +EAGGK G+ P D+ T +Y 
Sbjct: 179 ILNLIGTIGVSGALYKALEFSGSVVENLSIEGRMTIANMAIEAGGKVGLFPVDAKTLEYC 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +         + +D+ A +    + DVT ++P VA PH PDN     E KD++I++  IG
Sbjct: 239 KAAGRTGDVEMRADEGASYERVVKIDVTGMKPQVACPHLPDNVKPVDEVKDMRIHQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVW 479
           SCT G+ ED   AA +       K  V   ++PAT  +W
Sbjct: 299 SCTNGRIEDLREAAAILKGRKADK-NVRLIVLPATPNIW 336

[174][TOP]
>UniRef100_C5UT24 3-isopropylmalate dehydratase, large subunit n=1 Tax=Clostridium
           botulinum E1 str. 'BoNT E Beluga' RepID=C5UT24_CLOBO
          Length = 419

 Score =  124 bits (312), Expect = 4e-27
 Identities = 67/162 (41%), Positives = 94/162 (58%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D+ T KYL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDNKTVKYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  T   ++   +D+ A +      ++  L P V+ PH PDN         V I++V IG
Sbjct: 239 KEHTVKEWKVYKADEDAEYDEVIEIELNTLRPTVSFPHLPDNTRTIDNANGVDIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   A  +     GKKVK  +   ++P TQK+++
Sbjct: 299 SCTNGRISDLRIARDIL---KGKKVKKGIRCIVIPGTQKIYL 337

[175][TOP]
>UniRef100_Q9UZ07 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Pyrococcus
           abyssi RepID=LEUC1_PYRAB
          Length = 423

 Score =  124 bits (312), Expect = 4e-27
 Identities = 67/162 (41%), Positives = 101/162 (62%), Gaps = 3/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA YK MEF GS +E L++E+RMT+ NM +EAG K G+I PD  T  Y+
Sbjct: 179 ILHTIGDIGVNGALYKVMEFSGSVIEELSVEQRMTMSNMAIEAGAKTGIIEPDKKTLDYV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRA-LARECK-DVKINRVY 356
           + +    ++   SD+ A++     +DVT  EP+VA PH P+N   +++  K ++KI++V+
Sbjct: 239 KERAKRKFKVYKSDEDAKYYKVIEYDVTNWEPVVAFPHLPENTVPISKAAKMNIKIDQVF 298

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVK-VPTFLVPATQKVW 479
           IGSCT G+ ED   AA++    G K  K V   ++P +  V+
Sbjct: 299 IGSCTNGRIEDLRMAAEIL--EGQKVAKWVRLIVIPCSPTVY 338

[176][TOP]
>UniRef100_C9KJM7 3-isopropylmalate dehydratase, large subunit n=2 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KJM7_9FIRM
          Length = 420

 Score =  124 bits (311), Expect = 5e-27
 Identities = 71/195 (36%), Positives = 113/195 (57%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA YKS+EF G  V++L M +R+T+ NM +EAGGK G+ P D +T  Y+
Sbjct: 178 ILTLIGMIGVDGALYKSLEFAGPGVKALTMTDRLTISNMAIEAGGKAGIFPFDEITKAYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYI 359
           + + + PYE V +D  A +  E   ++++L+P+VA PH P N     + K+ ++I++V I
Sbjct: 238 DARVTKPYEPVAADDDAEYCREVDINLSELKPVVAFPHLPGNTKRVEDIKEPIEIDQVII 297

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AA +     G KV  +V   ++P +  ++ +        S  +    
Sbjct: 298 GSCTNGRLEDMEIAASIL---KGHKVADRVRCIVIPGSPAIYKE--------SMKRGYID 346

Query: 534 IFEEAGCDTPASPSC 578
            F +AGC   ++P+C
Sbjct: 347 TFIDAGC-AVSTPTC 360

[177][TOP]
>UniRef100_B5IER5 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IER5_9EURY
          Length = 418

 Score =  124 bits (311), Expect = 5e-27
 Identities = 60/162 (37%), Positives = 96/162 (59%), Gaps = 2/162 (1%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L I+G++T +GA YK++EF G T++ + +  RM L NM  E G KNG+I  D  T  YL+
Sbjct: 178 LHIVGDVTASGAVYKAVEFKGETIKDMTIASRMVLTNMSAEMGAKNGIIEADEKTEAYLK 237

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
            +   PYE ++ D+ A +   Y +D + L P +A PH+ DN     + + +++N+V++G+
Sbjct: 238 TRARAPYEIMHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGIEVNQVFLGT 297

Query: 366 CTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           CT G+ ED   AA++     GKKV   V   + PA+  VW +
Sbjct: 298 CTNGRVEDLEIAARIL---KGKKVNKNVRMLVFPASWDVWRE 336

[178][TOP]
>UniRef100_B2TIQ9 3-isopropylmalate dehydratase large subunit n=1 Tax=Clostridium
           botulinum B str. Eklund 17B RepID=LEUC_CLOBB
          Length = 419

 Score =  124 bits (311), Expect = 5e-27
 Identities = 66/162 (40%), Positives = 93/162 (57%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEFVG  +  L+M++R T+ NM +EAGGKNG+ P D  T +YL
Sbjct: 179 ILHIIGMIGVDGALYKSMEFVGDGLNYLSMDDRFTMANMAIEAGGKNGIFPVDDKTVEYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  T   +E   +D+ A +      ++  L P V+ PH PDN        D+ I++V IG
Sbjct: 239 KEHTKKEWEVYKADEDAEYDEVIEIELNTLRPTVSFPHLPDNTRTIDNVGDIDIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SCT G+  D   A  +     GKKVK  +   ++P TQ +++
Sbjct: 299 SCTNGRISDLRIARDIL---KGKKVKKGIRCIVIPGTQNIYL 337

[179][TOP]
>UniRef100_B2J8P2 Homoaconitate hydratase family protein n=1 Tax=Nostoc punctiforme
           PCC 73102 RepID=B2J8P2_NOSP7
          Length = 569

 Score =  124 bits (310), Expect = 7e-27
 Identities = 75/187 (40%), Positives = 103/187 (55%), Gaps = 4/187 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL I+G+I  AGAT K MEF GS +  L  +ER+TL NM VE G   G+I PD VT +YL
Sbjct: 330 ILFILGQIGCAGATSKVMEFRGSILAQLPFDERLTLANMAVECGAICGLIVPDEVTREYL 389

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + + S  ++ +  D  A +   Y+FD++ LEP VA+P  PD      + +++ I + +IG
Sbjct: 390 KNRVSEEFQEIIGDADAEYERVYQFDLSSLEPQVARPPKPDRVVAISQLENIPITKAFIG 449

Query: 363 SCTGGKTEDFMAAAKVF----LASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCS 530
           SCTGGK  D   AA+V     LA G     V  F+VPAT ++      L           
Sbjct: 450 SCTGGKLYDLAQAAEVLKGRQLADG-----VNLFIVPATIEIREQAQELGY--------I 496

Query: 531 QIFEEAG 551
            IFE+AG
Sbjct: 497 DIFEQAG 503

[180][TOP]
>UniRef100_O28084 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Archaeoglobus
           fulgidus RepID=LEUC2_ARCFU
          Length = 416

 Score =  124 bits (310), Expect = 7e-27
 Identities = 71/186 (38%), Positives = 109/186 (58%), Gaps = 3/186 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++IG++ V GATYK++EF G   E++ +EER+T+ NM VE G K G+   D  T K+L
Sbjct: 174 ILKLIGDLGVDGATYKALEFHGECAENMTVEERLTIANMAVECGAKAGIFESDENTRKFL 233

Query: 183 -EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
            E      +  V +D+ A +  E   DV+ L P+V+KPH+ DN A   E +  ++N+VYI
Sbjct: 234 AELGREGDFREVKADEDAEYEKEIYMDVSSLVPVVSKPHNVDNVAEISEVEGTEVNQVYI 293

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           G+CT G+  D   AA++     G+KVK  V   +VPA+++V++            K   +
Sbjct: 294 GTCTNGRLSDLEVAARIL---KGRKVKEGVRLIVVPASRRVYLQALD--------KGLIR 342

Query: 534 IFEEAG 551
           +F EAG
Sbjct: 343 VFVEAG 348

[181][TOP]
>UniRef100_C1DUH4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Sulfurihydrogenibium azorense Az-Fu1
           RepID=C1DUH4_SULAA
          Length = 431

 Score =  123 bits (308), Expect = 1e-26
 Identities = 62/161 (38%), Positives = 100/161 (62%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IG+I V GA YK+ME+ G  +++L+++ R+T+ NM +EAGGKN VI  D  T +++
Sbjct: 179 VLTVIGKIGVDGALYKAMEYHGEAIKALDIDNRLTIANMAIEAGGKNAVIEADEKTIEWV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T+  ++   SD  A++  EY FD  K+EP+VA P+ P N     E     I++V+IG
Sbjct: 239 RKRTNREFKIYKSDPDAKYCCEYEFDANKIEPVVACPNLPSNVKPVSEVAGTHIDQVFIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+  D   AA +     GKKV  +V   ++PA+ +++
Sbjct: 299 SCTNGRLSDLRIAAAIL---KGKKVHPEVRCIVIPASDQIY 336

[182][TOP]
>UniRef100_C6PDK3 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571
           RepID=C6PDK3_CLOTS
          Length = 418

 Score =  123 bits (308), Expect = 1e-26
 Identities = 66/163 (40%), Positives = 100/163 (61%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA YKSMEF G  + SL++++R T+ NM +EAG KNG+   D +T  Y+
Sbjct: 178 ILYIIGMIGVDGALYKSMEFTGD-ISSLSIDDRFTIANMAIEAGAKNGIFDYDEITETYV 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+ +  Y+   +D+ A ++  Y  D++K++P VA PH P+N     E  ++KI++V IG
Sbjct: 237 KGRANRKYKVFKADKDADYVESYDIDLSKIKPQVAFPHLPENTKPIDEVGNIKIDQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D     +V     GKKV   V   + PATQ ++++
Sbjct: 297 SCTNGRISDMEVTYEVL---KGKKVHPDVRLIIFPATQDIYLE 336

[183][TOP]
>UniRef100_C5F2A2 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           pullorum MIT 98-5489 RepID=C5F2A2_9HELI
          Length = 422

 Score =  123 bits (308), Expect = 1e-26
 Identities = 66/172 (38%), Positives = 109/172 (63%), Gaps = 7/172 (4%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I +I V GA Y+++EF G  ++ L M++R +LCNM +EAG KNG+I PD +T ++L
Sbjct: 178 ILEVIRQIGVDGALYQTLEFCGEGIKYLGMDDRFSLCNMAIEAGAKNGIIAPDEITREFL 237

Query: 183 EGKTSV---PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKIN 347
           + +  +   P E  YSD  A +    + D++KLEP++A P  P N +++++  K D+KI+
Sbjct: 238 KSRPFLRANPRE-FYSDADANYTQTIQIDISKLEPVIAYPFLPSNGKSISQALKDDLKID 296

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL 497
           +V+IGSCT G+  D   A+++     GKKV   V   + P TQ ++ + + L
Sbjct: 297 QVFIGSCTNGRLSDLKIASEIL---KGKKVHQDVRLIITPGTQNIYKEAHKL 345

[184][TOP]
>UniRef100_A2SR25 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Methanocorpusculum labreanum Z RepID=A2SR25_METLZ
          Length = 392

 Score =  123 bits (308), Expect = 1e-26
 Identities = 62/162 (38%), Positives = 95/162 (58%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL + G+I   GATY+++EF G+    +++  RMT  NM +E G K G++PPD  T++Y+
Sbjct: 152 ILTLAGDIGADGATYRALEFCGNAFSEMDIPGRMTCANMAIEMGAKAGIVPPDEKTWEYM 211

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+T V   S+ SD+ A F     +D+ K+ P +A PH+ DN     E     +++V+IG
Sbjct: 212 RGRTEVTPFSLASDEDAVFFETRNYDIAKINPKIAVPHNVDNVVDVTEVAGKPVDQVFIG 271

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDV 488
           SCT G+ EDF  AA+V L        V   +VPA++  +M V
Sbjct: 272 SCTNGRYEDFAEAAEV-LGDNVFSEDVRVIMVPASKAEYMKV 312

[185][TOP]
>UniRef100_C8SBC1 Homoaconitate hydratase family protein n=1 Tax=Ferroglobus placidus
           DSM 10642 RepID=C8SBC1_FERPL
          Length = 427

 Score =  123 bits (308), Expect = 1e-26
 Identities = 66/163 (40%), Positives = 100/163 (61%), Gaps = 3/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+ V GATYK++EF G T++ L+M+ R+T+ NM +E G K G+   D VT K+L
Sbjct: 185 ILWIIGELGVDGATYKALEFHGETIDKLDMDSRLTIANMAIECGAKAGLFKSDEVTKKFL 244

Query: 183 -EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
            E      +  +  D+ A +  E  FDV+ L P+VAKPH  DN A   E + VK+++V++
Sbjct: 245 MERGRGDKFREIKPDEDAEYEKEMYFDVSDLTPIVAKPHQVDNIARIDEVEGVKVDQVFV 304

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           G+CT G+  D    A++     G+KV   V   + PA+++V+M
Sbjct: 305 GTCTNGRLSDLEVVARIL---KGRKVHKDVRLLVGPASREVYM 344

[186][TOP]
>UniRef100_C7P908 3-isopropylmalate dehydratase n=1 Tax=Methanocaldococcus fervens
           AG86 RepID=C7P908_METFA
          Length = 420

 Score =  123 bits (308), Expect = 1e-26
 Identities = 64/169 (37%), Positives = 97/169 (57%), Gaps = 9/169 (5%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L++  EI   GATY ++E+ G  V+ +NM+ R+TLCNM +E GGK GVI  D +TY YL
Sbjct: 172 VLRVCKEIGRRGATYMAIEYGGEVVKRMNMDGRLTLCNMAIEMGGKTGVIEADEITYNYL 231

Query: 183 EGKTSVPYESV---------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 335
           + +  +  E +          +  +A +  E   D+T +E  VA PH PDN     E + 
Sbjct: 232 KNERGLSDEKIAELKKERITVNKDEANYYREIEIDITDMEEQVAVPHHPDNVKPVSEVEG 291

Query: 336 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
            +IN+V+IGSCT G+  D   AAK +L  G     V   ++PA++KV++
Sbjct: 292 TEINQVFIGSCTNGRLSDLREAAK-YLKGGKVHKDVKLIVIPASKKVFL 339

[187][TOP]
>UniRef100_B2V844 3-isopropylmalate dehydratase large subunit n=1
           Tax=Sulfurihydrogenibium sp. YO3AOP1 RepID=LEUC_SULSY
          Length = 431

 Score =  123 bits (308), Expect = 1e-26
 Identities = 60/159 (37%), Positives = 98/159 (61%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IG+I V GA YK+ME+ G  + +L+++ R+T+ NM +EAGGK+G+I PD  T  ++
Sbjct: 179 VLTVIGKIGVDGALYKAMEYQGEAIRALDIDNRLTIANMAIEAGGKSGIIEPDEKTVDWV 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +T+  ++   SD  A++  EY FD +K+EP+VA P  P N     E     I++V+IG
Sbjct: 239 RKRTNREFKLYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTHIDQVFIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVW 479
           SCT G+  D   AA + L S     +V   ++PA+ +++
Sbjct: 299 SCTNGRLSDLRIAAAI-LKSKKVHPEVRCIVIPASDQIY 336

[188][TOP]
>UniRef100_C5CJ10 Homoaconitate hydratase family protein n=1 Tax=Kosmotoga olearia
           TBF 19.5.1 RepID=C5CJ10_KOSOT
          Length = 417

 Score =  122 bits (307), Expect = 2e-26
 Identities = 74/194 (38%), Positives = 106/194 (54%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I   GA YK MEF G  +E ++ E R T+ NM +EAG K+G+I PD  T  +L
Sbjct: 174 ILHIIGLIGADGANYKVMEFEGEVIEQISQEARFTITNMAIEAGAKSGIIAPDEKTRAFL 233

Query: 183 E--GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVY 356
              G+ S  Y  + SD  A +   Y  DV+ LEP VA PH+ DN     E + +KI++V+
Sbjct: 234 RAYGRES-DYREIKSDPDAVYEKIYEIDVSNLEPAVALPHTVDNTKSISEVEGIKIDQVF 292

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           IG+CT G+ ED   AA + L    K   V   ++PA+++V++            +   +I
Sbjct: 293 IGTCTNGRLEDLRVAASI-LKGREKHPDVRLIVIPASKEVYLKALE--------EGLIKI 343

Query: 537 FEEAGCDTPASPSC 578
           F E+G  T  +P C
Sbjct: 344 FVESGA-TVLAPGC 356

[189][TOP]
>UniRef100_A7B6Z9 Putative uncharacterized protein n=1 Tax=Ruminococcus gnavus ATCC
           29149 RepID=A7B6Z9_RUMGN
          Length = 425

 Score =  122 bits (307), Expect = 2e-26
 Identities = 73/197 (37%), Positives = 105/197 (53%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG+I V GA YKSMEF G  +  L+M++R T+ NM +EAG KNG+ P D  T  YL
Sbjct: 178 IIHIIGKIGVDGALYKSMEFTGDGIAHLSMDDRFTMANMAIEAGAKNGIFPVDEQTKAYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
           E  +   Y+   +D+ A +      D++++ P VA PH P N     E    + +KI++V
Sbjct: 238 EEHSKKEYQIFEADEDADYEQVVTIDLSEVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
            IGSCT G+ ED   AA + L        V   ++PATQK++             +    
Sbjct: 298 VIGSCTNGRMEDMRKAAAI-LKGHTVHPDVRVMVIPATQKIYKQCIK--------EGLLD 348

Query: 534 IFEEAGC--DTPASPSC 578
           IF +AGC  +TP+   C
Sbjct: 349 IFVDAGCAVNTPSCGPC 365

[190][TOP]
>UniRef100_B5IEF0 Homoaconitate hydratase family protein n=1 Tax=Aciduliprofundum
           boonei T469 RepID=B5IEF0_9EURY
          Length = 418

 Score =  122 bits (307), Expect = 2e-26
 Identities = 58/160 (36%), Positives = 95/160 (59%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L IIG+IT +GA YK++EF G T+ ++++  R+ L NM  E G KNG+I  D  T  YL+
Sbjct: 178 LHIIGDITASGAVYKAVEFKGETIRNMSIASRIVLTNMSAEMGAKNGIIEADEKTEAYLK 237

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
            +   PYE ++ D+ A +   Y +D + L P +A PH+ DN     + + +++N+V++G+
Sbjct: 238 TRARAPYEIMHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDIDKAEGIEVNQVFLGT 297

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           CT G+ ED   AA++   +   K  V   + PA+  VW +
Sbjct: 298 CTNGRVEDLEVAARILKGNKVNK-NVRMLVFPASWDVWRE 336

[191][TOP]
>UniRef100_B9L6Y8 3-isopropylmalate dehydratase large subunit n=1 Tax=Nautilia
           profundicola AmH RepID=LEUC_NAUPA
          Length = 425

 Score =  122 bits (307), Expect = 2e-26
 Identities = 72/168 (42%), Positives = 103/168 (61%), Gaps = 9/168 (5%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I  I V GA YK++EF G  +E+L M++RM+LCNM +EAG KNG++  D +T  +L
Sbjct: 178 ILELIRRIGVDGALYKALEFTGEVIENLPMDDRMSLCNMAIEAGAKNGIVAYDKITEAFL 237

Query: 183 EG-KTSVPYESV----YSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVK 341
           E  K   P  S     YSD  A +      DV KLEPLVA P  P N + +++  K D++
Sbjct: 238 EEVKKYNPLRSEPKIHYSDPDANYSQVIEIDVNKLEPLVAYPFLPSNGKPISQAVKDDIE 297

Query: 342 INRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           I++VYIGSCT G   D   AA++     GK+V  +V   + PATQ+++
Sbjct: 298 IDQVYIGSCTNGTLSDLRIAAEIL---KGKRVHRRVRLIVTPATQRIY 342

[192][TOP]
>UniRef100_C6PJB4 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermoanaerobacter italicus Ab9 RepID=C6PJB4_9THEO
          Length = 418

 Score =  122 bits (306), Expect = 2e-26
 Identities = 66/163 (40%), Positives = 99/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEF G+ +++L+M++R T+ NM +EAG KNG+   D +T  Y+
Sbjct: 178 ILYIIGKIGVDGALYKSMEFTGN-IKTLSMDDRFTIANMAIEAGAKNGIFDFDEITEAYV 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    Y+    D+ A +   Y  ++ ++ P VA PH P+N     E   VKI++V IG
Sbjct: 237 KGRAKREYKVFERDEDAEYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKVKIDQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D   A K+     GKKV   V   + PATQ+++++
Sbjct: 297 SCTNGRLSDMEIAYKIL---KGKKVHPDVRLLIFPATQEIYLE 336

[193][TOP]
>UniRef100_C4ETQ1 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermanaerovibrio acidaminovorans DSM 6589
           RepID=C4ETQ1_9BACT
          Length = 420

 Score =  122 bits (306), Expect = 2e-26
 Identities = 70/193 (36%), Positives = 110/193 (56%), Gaps = 1/193 (0%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG+I   GA Y S+EF G  +  +++ ERMTLCNM +E G KN V PPD     ++
Sbjct: 180 ILKIIGDIGADGADYMSVEFHGEGILQMSLSERMTLCNMGIEMGAKNAVCPPDQKVLDHV 239

Query: 183 EG-KTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
                S  +E++++DQ A +  E  + +++L P VAKPH+ DN A   + K  +I++ +I
Sbjct: 240 RDIAKSDQWEAIWADQGATYAKELSYCLSELVPGVAKPHTVDNYAPVDQVKGAQIHQAFI 299

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIF 539
           GSCT G+ ED   AA +     G++V V T ++PA+ +V+             +   + F
Sbjct: 300 GSCTNGRIEDLREAATIL---KGRQVAVRTIVIPASWRVYRQAME--------EGLLETF 348

Query: 540 EEAGCDTPASPSC 578
            +AGC   ++P C
Sbjct: 349 LDAGC-VISNPGC 360

[194][TOP]
>UniRef100_C3XJX6 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           winghamensis ATCC BAA-430 RepID=C3XJX6_9HELI
          Length = 422

 Score =  122 bits (306), Expect = 2e-26
 Identities = 66/171 (38%), Positives = 108/171 (63%), Gaps = 6/171 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II +I V GA Y+++EF G  +  L+M++R +LCNM +EAG KNG+I PDS+T ++L
Sbjct: 178 ILEIIRQIGVDGALYQALEFCGEGISYLSMDDRFSLCNMAIEAGAKNGIIAPDSITREFL 237

Query: 183 EGKTSV--PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKD-VKINR 350
             ++++    +  +SD  A +      D++KLEP+VA P  P N + +++  KD +KI++
Sbjct: 238 ASRSNLRAKPKEFFSDIDANYTRTLTIDISKLEPVVAYPFLPSNGKNISQAVKDNLKIDQ 297

Query: 351 VYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL 497
            +IGSCT G+  D   A+++     GKKV   V   + P TQ+++ D + L
Sbjct: 298 AFIGSCTNGRLSDLKIASEIL---KGKKVHKDVRLIITPGTQQIYKDAHKL 345

[195][TOP]
>UniRef100_B6BGP4 3-isopropylmalate dehydratase large subunit n=1
           Tax=Campylobacterales bacterium GD 1 RepID=B6BGP4_9PROT
          Length = 419

 Score =  122 bits (306), Expect = 2e-26
 Identities = 68/170 (40%), Positives = 103/170 (60%), Gaps = 5/170 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II  I V GA YK++EF GST+E LNM++R ++CNM +EAG K+G++  D +T ++L
Sbjct: 178 ILEIIRMIGVDGALYKTLEFTGSTIEHLNMDDRFSMCNMAIEAGAKSGIVAYDDITKEFL 237

Query: 183 EGKTSVPYESV-YSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKD-VKINRV 353
             K       + YSD  A ++     +V +LEP++A P  P N  ++ +  KD +KI++ 
Sbjct: 238 ADKDLAREPKIHYSDADAAYVQVLDINVAELEPVIAYPFLPSNGHSITQAVKDKIKIDQA 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL 497
           +IGSCT G+  D   AA++     GKKV   V   + P TQK+  + Y L
Sbjct: 298 FIGSCTNGRLGDLKTAAEIL---DGKKVHEDVRLIVTPGTQKILKEAYRL 344

[196][TOP]
>UniRef100_A8ABG2 3-isopropylmalate dehydratase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8ABG2_IGNH4
          Length = 429

 Score =  122 bits (306), Expect = 2e-26
 Identities = 68/188 (36%), Positives = 111/188 (59%), Gaps = 4/188 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+IIG++   GATY S EFVG  ++ + ++ R+T+ NMVVE G K G++P D    +++
Sbjct: 177 ILKIIGDLKEDGATYMSAEFVGDGLKDMRIDSRLTVSNMVVEMGAKVGLMPADEEVMRFV 236

Query: 183 EGKT-SVPY-ESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVY 356
           EG+   VP  E  + D  A +  E+ +D++++EP+VAKP+SP N     E + +++++V+
Sbjct: 237 EGRARGVPKPELTFPDPGAHYKDEFTYDLSEIEPMVAKPYSPANSVPVSEVEGIEVDQVF 296

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVPGSGGKTCS 530
           IGSCT G+ ED   AA++     GKKV   T   ++ A++ V++            K   
Sbjct: 297 IGSCTNGRLEDVAVAARIL---KGKKVAPNTRCIVITASRNVYLQALK--------KGYV 345

Query: 531 QIFEEAGC 554
            +  EAGC
Sbjct: 346 DVLTEAGC 353

[197][TOP]
>UniRef100_A0B7A3 3-isopropylmalate dehydratase, large subunit n=1 Tax=Methanosaeta
           thermophila PT RepID=A0B7A3_METTP
          Length = 382

 Score =  122 bits (306), Expect = 2e-26
 Identities = 59/159 (37%), Positives = 98/159 (61%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L ++ E+   GA Y S+EFVG  VE L++  RMTLCNM VE G K  ++PPD     YL 
Sbjct: 147 LFVVKEMGADGANYMSVEFVGGAVERLSISGRMTLCNMGVEMGAKAAIVPPDESVDAYLA 206

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
            +   PY  ++SD    +  E  +DV+ + P++A P+  DN    R+   +++++V+IG+
Sbjct: 207 RRARRPYTHIHSD-PGSYYREIEYDVSDIPPMIAAPYRVDNVHPVRDLAGIEVDQVFIGT 265

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
           CT G+ ED   AA++     GK+VK+ T ++PA++++++
Sbjct: 266 CTNGRLEDLEMAARIV---KGKRVKIRTLVIPASREIYL 301

[198][TOP]
>UniRef100_Q3Z894 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z894_DEHE1
          Length = 416

 Score =  122 bits (305), Expect = 3e-26
 Identities = 64/163 (39%), Positives = 96/163 (58%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y +M F G  +++L+ME R T+ NM +EAGGK G+   D  T +Y+
Sbjct: 176 ILFTIGQIGVDGALYSAMYFCGEAIDALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y    +D  A +   Y FD++KLEP V+ PHSP N     +   +K+++V IG
Sbjct: 236 TPRAKRQYTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPISQIGKIKVDQVIIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           SCT G+ ED   +AK+     G KV   + T ++P +Q+V++D
Sbjct: 296 SCTNGRLEDLAISAKLL---EGNKVSPDLRTIVIPGSQQVYLD 335

[199][TOP]
>UniRef100_C2KW91 3-isopropylmalate dehydratase n=1 Tax=Oribacterium sinus F0268
           RepID=C2KW91_9FIRM
          Length = 421

 Score =  121 bits (304), Expect = 3e-26
 Identities = 61/163 (37%), Positives = 98/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA Y+S+EF G  V SL+M++R  +CNM +EAGGKNG+ P D  T +Y+
Sbjct: 179 ILHLIGMIGVDGALYESIEFTGEGVASLSMDDRFAICNMAIEAGGKNGIFPVDEKTLEYI 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +  ++  Y    +D+ A +      D++ L+  VA PH P+N       + + I++  IG
Sbjct: 239 KAHSNKEYHIYEADEDAEYDRVIEIDLSSLKSTVAFPHLPENTHEIGSFEKISIDQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D   AA++   + G+K+   V   ++PATQK++++
Sbjct: 299 SCTNGRLSDIKVAAEI---ARGRKIAENVRCIVIPATQKIYLE 338

[200][TOP]
>UniRef100_B8I2I1 Homoaconitate hydratase family protein n=1 Tax=Clostridium
           cellulolyticum H10 RepID=B8I2I1_CLOCE
          Length = 418

 Score =  121 bits (303), Expect = 4e-26
 Identities = 64/158 (40%), Positives = 97/158 (61%), Gaps = 1/158 (0%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L +IG++ + GA Y  +EF G  +++L++  R+TLCNMV+E G K G+I  D+VT KY  
Sbjct: 179 LYLIGQLGINGANYDMLEFDGELIKNLDISSRLTLCNMVIEMGAKAGIINADAVTQKYFR 238

Query: 186 GKTSVPYESVY-SDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            K     +  + SD  AR+      DV+K+EP++A P+SP N   A+E  D+KI++V IG
Sbjct: 239 EKNLKTEDIDFNSDNGARYKKIIEIDVSKIEPVIACPYSPGNIKTAKELVDLKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKV 476
           SCT G+ EDF  A K +L       +V   ++P +Q+V
Sbjct: 299 SCTNGRIEDFRVAHK-YLKDNEVHHEVKLIVIPGSQEV 335

[201][TOP]
>UniRef100_A1HRB9 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HRB9_9FIRM
          Length = 420

 Score =  121 bits (303), Expect = 4e-26
 Identities = 68/161 (42%), Positives = 97/161 (60%), Gaps = 3/161 (1%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L+ IG I  AGATYK++E+VG  + +L ++ERM + NM VE G K G++ PD+   +YL+
Sbjct: 179 LKTIGTIGHAGATYKAVEYVGDAITNLCLDERMAITNMAVEMGAKAGLMAPDTKVVEYLK 238

Query: 186 GK-TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            +  +  Y    SD  A F + YRFD ++LEP+VA PH  DN       K   I++ YIG
Sbjct: 239 ARGITEGYTLFASDSDAVFCATYRFDASELEPVVACPHEVDNVTELSNVKGQVIHQAYIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVW 479
           SCTGG+  D  AAA+V     G+KV   V   + PA+ ++W
Sbjct: 299 SCTGGRYNDLAAAARVL---KGRKVANGVRLLVSPASHEIW 336

[202][TOP]
>UniRef100_A8EQZ0 3-isopropylmalate dehydratase large subunit n=1 Tax=Arcobacter
           butzleri RM4018 RepID=LEUC_ARCB4
          Length = 426

 Score =  121 bits (303), Expect = 4e-26
 Identities = 67/175 (38%), Positives = 105/175 (60%), Gaps = 10/175 (5%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II  + V GA YK++EF G T++ L+M++R +LCNM +EAG KNG++  D +T ++L
Sbjct: 178 ILEIIRILGVDGALYKALEFTGDTIQYLSMDDRFSLCNMAIEAGAKNGIVAYDEITKEFL 237

Query: 183 E------GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECKD-V 338
           +      G      +  YSD+ A +      DV KLEP++A P+ P N  ++++   D +
Sbjct: 238 DKVGEANGGLRAEPKIHYSDEDANYCQVIEIDVAKLEPVIAYPYLPSNGHSVSQAVSDNI 297

Query: 339 KINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL 497
           K+++V+IGSCT G+  DF  AA++     G+KV   V   L P TQK+  +   L
Sbjct: 298 KVDQVFIGSCTNGRLSDFKIAAEIL---AGQKVARHVRLILTPGTQKILREATKL 349

[203][TOP]
>UniRef100_A5FR41 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. BAV1 RepID=A5FR41_DEHSB
          Length = 416

 Score =  120 bits (302), Expect = 6e-26
 Identities = 62/161 (38%), Positives = 93/161 (57%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+  V GA Y +M F G  +E+L+ME R T+ NM +EAGGK G+   D  T +Y+
Sbjct: 176 ILYTIGQTGVDGALYSAMFFCGEAIEALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y    +D  A +   Y FD++KLEP V+ PHSP N     +   +K+++V IG
Sbjct: 236 TPRAKRQYTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPVSQIGKIKVDQVIIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           SCT G+ ED   +AK+ L        + T ++P +Q+V++D
Sbjct: 296 SCTNGRLEDLAVSAKL-LKGNVVHPDLRTIVIPGSQQVYLD 335

[204][TOP]
>UniRef100_Q0QLE2 2,3-dimethylmalate dehydratase large subunit n=1 Tax=Eubacterium
           barkeri RepID=Q0QLE2_EUBBA
          Length = 420

 Score =  120 bits (302), Expect = 6e-26
 Identities = 69/164 (42%), Positives = 97/164 (59%), Gaps = 3/164 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEF G  V  L+M++R T+ NM +EAGGKNG+ P D  T  Y+
Sbjct: 179 ILHIIGMIGVDGALYRSMEFTGPGVACLSMDDRFTISNMAIEAGGKNGIFPVDDQTISYM 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD-VKINRVYI 359
           E   S  Y+   +D  A +   +  D+++L+  VA PH P+N       ++ V I++V I
Sbjct: 239 EEHGSGDYKVYAADADAVYEKTFDIDLSQLKSTVAFPHLPENTKTVDAIEEPVTIDQVVI 298

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           GSCT G+ ED   AA +     GK VK  V   ++PAT K+++D
Sbjct: 299 GSCTNGRFEDLKRAADIL---RGKHVKKGVRMLVIPATHKIYLD 339

[205][TOP]
>UniRef100_C6JHQ9 Putative uncharacterized protein n=1 Tax=Ruminococcus sp.
           5_1_39BFAA RepID=C6JHQ9_9FIRM
          Length = 416

 Score =  120 bits (302), Expect = 6e-26
 Identities = 65/161 (40%), Positives = 92/161 (57%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGEI   G  Y++MEF G   ++L++ +RM LCNM VEAG K G+   D    +YL
Sbjct: 176 ILTIIGEIGANGCNYQAMEFTGEGAKTLSISDRMALCNMAVEAGAKTGIFEADEKAIEYL 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +     P    +SD  A +  EY FD++K+ P+VAKP   DN   A E   ++IN  ++G
Sbjct: 236 KEHGREPKAVYHSDPDAVYAREYTFDLSKVRPVVAKPDFVDNVVPAEEACGIEINEAFLG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVW 479
           SC  G+ ED    A++     GKKV   V   +VPA+Q ++
Sbjct: 296 SCNNGRIEDLRVGAEII---KGKKVAEGVRFLVVPASQTIY 333

[206][TOP]
>UniRef100_B6FST2 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM
           1787 RepID=B6FST2_9CLOT
          Length = 438

 Score =  120 bits (302), Expect = 6e-26
 Identities = 74/199 (37%), Positives = 107/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEFVG  + +L+M++R T+ NM +EAG KNG+   D     Y+
Sbjct: 192 ILHIIGKIGVDGALYKSMEFVGDGIANLSMDDRFTMANMAIEAGAKNGIFIVDEKAEAYM 251

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRAL---ARECKDVKINRV 353
           +  +   Y+   +D+ A +      D++K+ P VA PH P N        E + +KI++V
Sbjct: 252 KEHSEKEYKVYTADEDAEYDEVVEIDLSKVRPTVAFPHLPGNAKTIDEVEEMEPIKIDQV 311

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+ ED   AA V     G KV   V   ++PATQK+++            +  
Sbjct: 312 VIGSCTNGRMEDMRRAAAVL---KGHKVHPDVRVMVIPATQKIYLQCIE--------EGL 360

Query: 528 SQIFEEAGC--DTPASPSC 578
              F E+GC  +TP+   C
Sbjct: 361 VTTFIESGCAFNTPSCGPC 379

[207][TOP]
>UniRef100_B5CQV8 Putative uncharacterized protein n=1 Tax=Ruminococcus lactaris ATCC
           29176 RepID=B5CQV8_9FIRM
          Length = 424

 Score =  120 bits (302), Expect = 6e-26
 Identities = 73/197 (37%), Positives = 103/197 (52%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG+I V GA YKSMEF G  +  L+M++R T+ NM +EAG KNG+ P D  T  YL
Sbjct: 178 IIHIIGQIGVDGALYKSMEFTGDGIACLSMDDRFTMANMAIEAGAKNGIFPVDEKTKAYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
                  Y    +D+ A +      D++K+ P VA PH P N     E    + +KI++V
Sbjct: 238 AEHCKKEYTVYEADEDAVYDEVIEIDLSKVRPTVAFPHLPGNAKTIDEVEAMEPIKIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
            IGSCT G+ ED   AA + L        V   ++PATQK++ +           +    
Sbjct: 298 VIGSCTNGRMEDLRKAAAI-LKGHTVHPDVRVMVIPATQKIYKECIK--------EGLLD 348

Query: 534 IFEEAGC--DTPASPSC 578
           IF +AGC  +TP+   C
Sbjct: 349 IFVDAGCAVNTPSCGPC 365

[208][TOP]
>UniRef100_A5UMS7 3-isopropylmalate dehydratase, large subunit, LeuC n=1
           Tax=Methanobrevibacter smithii ATCC 35061
           RepID=A5UMS7_METS3
          Length = 415

 Score =  120 bits (302), Expect = 6e-26
 Identities = 66/161 (40%), Positives = 100/161 (62%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG++ V G+TYK+ EF G TV ++++ +RM L NM +E GGK G++ PD  T  Y+
Sbjct: 178 ILNIIGQVGVDGSTYKACEFAGETVSNMSISDRMVLTNMAIEMGGKTGLVEPDKKTIDYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +++  Y+   +D  A  L+    DV++LEP VA PH  DN     E  D +I++V++G
Sbjct: 238 ESRSNKAYKVFKTDLDAPSLNIIDIDVSELEPQVACPHHVDNVKAVSEV-DQEIDQVFLG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVW 479
           SCT G+  D   AAK+     GKKV   T   ++PA+++V+
Sbjct: 297 SCTNGRISDLRDAAKIL---KGKKVAKGTRMLVIPASKEVY 334

[209][TOP]
>UniRef100_C5U763 Homoaconitate hydratase family protein n=1 Tax=Methanocaldococcus
           infernus ME RepID=C5U763_9EURY
          Length = 424

 Score =  120 bits (302), Expect = 6e-26
 Identities = 63/165 (38%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIGE+ V GATYK+ +F G TV+++++  RMT+ NM +E GGK G+I PD  T  Y+
Sbjct: 178 ILSIIGEVGVDGATYKACQFGGETVKNMSIASRMTMTNMAIEMGGKTGIIEPDEKTINYV 237

Query: 183 EGK-----TSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKIN 347
           +       T   ++ +  D+ A F   Y  +  K+EP+ A PH+ DN    RE     I+
Sbjct: 238 KEAMEKHGTLREFKPIKGDEDAEFSEVYEIEADKIEPVFACPHNVDNVKQCREVAGKPID 297

Query: 348 RVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
           +V+IGSCT G+ ED   A  V    GG    V   + PA+++ ++
Sbjct: 298 QVFIGSCTNGRLEDLRMAINVIEKHGGIAEDVRVIVTPASREEYL 342

[210][TOP]
>UniRef100_B0K0Y2 3-isopropylmalate dehydratase large subunit n=4
           Tax=Thermoanaerobacter RepID=LEUC_THEPX
          Length = 418

 Score =  120 bits (302), Expect = 6e-26
 Identities = 65/163 (39%), Positives = 99/163 (60%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEF G+ +++L++++R T+ NM +EAG KNG+   D +T  Y+
Sbjct: 178 ILYIIGKIGVDGALYKSMEFTGN-IKALSIDDRFTIANMAIEAGAKNGIFDFDEITEAYV 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    Y+    D+ A +   Y  ++ ++ P VA PH P+N     E   VKI++V IG
Sbjct: 237 KGRAKREYKVFERDEDAEYSEVYEINLDEIRPQVAFPHLPENTRSIDEVGKVKIDQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D   A K+     GKKV   V   + PATQ+++++
Sbjct: 297 SCTNGRLSDMEIAYKIL---KGKKVHPDVRLLIFPATQEIYLE 336

[211][TOP]
>UniRef100_C5ZZ28 3-isopropylmalate dehydratase, large subunit n=1 Tax=Helicobacter
           canadensis MIT 98-5491 RepID=C5ZZ28_9HELI
          Length = 421

 Score =  120 bits (301), Expect = 8e-26
 Identities = 63/171 (36%), Positives = 108/171 (63%), Gaps = 6/171 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I +I V GA Y+++EF G  ++ L+M++R +LCNM +EAG KNG+I  D +T ++L
Sbjct: 178 ILEVIRQIGVDGALYQTLEFCGDGIQYLSMDDRFSLCNMAIEAGAKNGIIASDEITREFL 237

Query: 183 EGKTSV--PYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDN-RALARECK-DVKINR 350
             +  +    +  YSD+ A +    + D++ LEP++A P  P N +++++  K D+KI++
Sbjct: 238 ASRKELRAKPKEFYSDKDANYTRVLKIDISTLEPVIAYPFLPSNGKSISQALKDDLKIDQ 297

Query: 351 VYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSL 497
           V+IGSCT G+  D   A+++     GKKV   V   + P TQ+++ + Y L
Sbjct: 298 VFIGSCTNGRLADLKIASEIL---KGKKVHKDVRLIVTPGTQQIYKEAYQL 345

[212][TOP]
>UniRef100_A8CP51 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. VS RepID=A8CP51_9CHLR
          Length = 416

 Score =  120 bits (301), Expect = 8e-26
 Identities = 62/161 (38%), Positives = 94/161 (58%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y +M F G  +++L+ME R T+ NM +EAGGK G+   D  T +Y+
Sbjct: 176 ILFTIGQIGVDGALYSAMYFCGEAIDALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y    +D  A +   Y FD++KLEP V+ PHSP N     +   +K+++V IG
Sbjct: 236 TPRAKRQYTVYDNDADASYAKTYNFDISKLEPQVSLPHSPANARPISQIGKIKVDQVIIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           SCT G+ ED   +AK+ L        + T ++P +Q+V++D
Sbjct: 296 SCTNGRLEDLAISAKL-LEVNKVNPDLRTIVIPGSQQVYLD 335

[213][TOP]
>UniRef100_A1HRB1 3-isopropylmalate dehydratase n=1 Tax=Thermosinus carboxydivorans
           Nor1 RepID=A1HRB1_9FIRM
          Length = 417

 Score =  120 bits (301), Expect = 8e-26
 Identities = 71/194 (36%), Positives = 106/194 (54%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++IG +    A YK++EF G  ++ L++ ERM LCNM  E G K   I PD +T +YL
Sbjct: 175 ILKVIGTLGADYAVYKAVEFTGPVLKQLSVSERMALCNMTTEMGAKTSYIQPDEITLEYL 234

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + K    YE  ++D   ++ +E+ FDV+ L+P VA PHS DN     E     + + ++G
Sbjct: 235 KDKVKGDYEIFHTDPGYQYAAEHTFDVSGLKPQVAAPHSVDNVHDITEYIGRPVQQAFLG 294

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           +CTGG+ +D   AAK+     GKKV   T   +VPA++ V+++           K   Q 
Sbjct: 295 TCTGGRVQDLAVAAKIL---KGKKVHPRTRFIVVPASKAVFLEAME--------KGYIQT 343

Query: 537 FEEAGCDTPASPSC 578
             EAG  T  +P C
Sbjct: 344 LVEAGA-TFVTPGC 356

[214][TOP]
>UniRef100_UPI0001966774 hypothetical protein METSMIF1_00490 n=1 Tax=Methanobrevibacter
           smithii DSM 2374 RepID=UPI0001966774
          Length = 415

 Score =  120 bits (300), Expect = 1e-25
 Identities = 66/161 (40%), Positives = 99/161 (61%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG++ V G+TYK+ EF G TV ++++ +RM L NM +E GGK G++ PD  T  Y+
Sbjct: 178 ILNIIGQVGVDGSTYKACEFAGETVSNMSISDRMVLTNMAIEMGGKTGLVEPDKKTIDYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +++  Y+   +D  A  L+    DV+ LEP VA PH  DN     E  D +I++V++G
Sbjct: 238 ESRSNKAYKVFKTDLDAPSLNIIDIDVSDLEPQVACPHHVDNVKAVSEV-DQEIDQVFLG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVW 479
           SCT G+  D   AAK+     GKKV   T   ++PA+++V+
Sbjct: 297 SCTNGRISDLRDAAKIL---KGKKVAKGTRMLVIPASKEVY 334

[215][TOP]
>UniRef100_Q3ZXI5 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Dehalococcoides sp. CBDB1 RepID=Q3ZXI5_DEHSC
          Length = 416

 Score =  120 bits (300), Expect = 1e-25
 Identities = 61/161 (37%), Positives = 93/161 (57%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+  V GA Y +M F G  +E+L+ME R T+ NM +EAGGK G+   D  T +Y+
Sbjct: 176 ILYTIGQTGVDGALYSAMFFCGEAIEALSMENRFTMSNMAIEAGGKAGLFRVDEKTLEYV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    Y    +D  A +   Y FD++K+EP V+ PHSP N     +   +K+++V IG
Sbjct: 236 TPRAKRQYTVYDNDADASYAKTYNFDISKIEPQVSLPHSPANARPVSQIGKIKVDQVIIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           SCT G+ ED   +AK+ L        + T ++P +Q+V++D
Sbjct: 296 SCTNGRLEDLAVSAKL-LKGNVVHPDLRTIVIPGSQQVYLD 335

[216][TOP]
>UniRef100_B0NJ74 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC
           35704 RepID=B0NJ74_EUBSP
          Length = 424

 Score =  120 bits (300), Expect = 1e-25
 Identities = 75/199 (37%), Positives = 106/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG I V GA YKSMEFVG  + SL M++R T+ NM +EAG KNG+   D    +Y+
Sbjct: 178 IIHIIGRIGVDGALYKSMEFVGDGIASLTMDDRFTMANMAIEAGAKNGIFLVDEKAEEYM 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
           +  +   Y+   +D  A + +    D+ K+ P VA PH P N     E    + +KI++V
Sbjct: 238 KEHSDKEYKIYEADADADYDAVVEVDLAKVRPTVAFPHLPGNAKTIDEIEAMEPIKIDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+ ED   AA V     G+KV   V   ++PATQK++             +  
Sbjct: 298 VIGSCTNGRMEDMRRAAAVL---KGRKVHPDVRVMVIPATQKIYKQCIK--------EGL 346

Query: 528 SQIFEEAGC--DTPASPSC 578
             IF +AGC  +TP+   C
Sbjct: 347 VDIFIDAGCAFNTPSCGPC 365

[217][TOP]
>UniRef100_B1L3C3 Homoaconitate hydratase family protein n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L3C3_KORCO
          Length = 384

 Score =  120 bits (300), Expect = 1e-25
 Identities = 69/163 (42%), Positives = 100/163 (61%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I  I V GA YK++EF GS ++ + M+ER  L NM VEAG K  +IP D VT  YL
Sbjct: 145 ILKLISMIGVDGANYKALEFNGSILKVMEMDERFVLTNMSVEAGAKTAIIPVDDVTLSYL 204

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+        YSD  +    E   DV+ LEPLVA PHSP N   A E  D +I++ +IG
Sbjct: 205 NGRLRRAPRPEYSDDGSH-SDEISIDVSSLEPLVAIPHSPANVKPASEV-DAEIDQAFIG 262

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           SCTGG+ +D   AA++     G++VK  V   ++PA+++++++
Sbjct: 263 SCTGGRLKDLEVAARIL---RGRRVKEGVRLIVIPASRRIYLE 302

[218][TOP]
>UniRef100_B0KAH5 3-isopropylmalate dehydratase large subunit n=3
           Tax=Thermoanaerobacter RepID=LEUC_THEP3
          Length = 417

 Score =  120 bits (300), Expect = 1e-25
 Identities = 66/163 (40%), Positives = 97/163 (59%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEF G+ +++L+M++R T+ NM +EAG KNG+   D +T  Y+
Sbjct: 178 ILYIIGKIGVDGALYKSMEFTGN-IKALSMDDRFTIANMAIEAGAKNGIFDFDEITEAYV 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    Y+    D  A +   Y   + ++ P VA PH P+N     E   VKI++V IG
Sbjct: 237 KGRAKREYKVFERDVDAEYSEVYEISLDEIRPQVAFPHLPENTRNIDEVGKVKIDQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D   A K+     GKKV   V   + PATQ+++++
Sbjct: 297 SCTNGRISDMEIAYKIL---KGKKVHPDVRLLIFPATQEIYLE 336

[219][TOP]
>UniRef100_C4Z1K2 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit n=1
           Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K2_EUBE2
          Length = 586

 Score =  119 bits (299), Expect = 1e-25
 Identities = 66/162 (40%), Positives = 94/162 (58%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I   GA YK+MEF G  + SL+M +R+++CN+ VEAG K  ++  D V   YL
Sbjct: 346 ILSIIGKIGANGANYKAMEFAGEGLHSLSMADRISICNLCVEAGAKTALMEVDDVAMDYL 405

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +     P     SD  A F   Y  D++ ++P+VAKPH  DN   A+E   VKI+  ++G
Sbjct: 406 KEHGREPKACFTSDDDAVFEQVYDIDLSTIQPIVAKPHFVDNVVPAKESLGVKIDEAFLG 465

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SC  G+ ED    A +     GKKV  KV   +VPA++ V++
Sbjct: 466 SCNNGRIEDLRVGAAII---KGKKVAPKVRFLVVPASRSVYL 504

[220][TOP]
>UniRef100_C4V4K3 3-isopropylmalate dehydratase n=1 Tax=Selenomonas flueggei ATCC
           43531 RepID=C4V4K3_9FIRM
          Length = 420

 Score =  119 bits (299), Expect = 1e-25
 Identities = 73/195 (37%), Positives = 108/195 (55%), Gaps = 3/195 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA YKS+EF G  V SL+M +R+T+ NM +EAG KNG+ P D V   Y+
Sbjct: 178 ILTLIGMIGVDGALYKSLEFTGEGVASLSMTDRLTIANMAIEAGAKNGIFPYDDVCRAYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC-KDVKINRVYI 359
           EG+ + P+  V +D  AR+      D++ L P+V+ PH P+N     +    + I++V I
Sbjct: 238 EGRMTKPFAPVAADADARYAQTVEIDLSALRPVVSFPHLPENTKRVMDIGAPIAIDQVVI 297

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQ 533
           GSCT G+ ED   AA +     G KV  +V   ++P +  V+ +        S  +    
Sbjct: 298 GSCTNGRLEDMEIAASIL---KGHKVHERVRCIVIPGSPYVYEE--------SMKRGYLA 346

Query: 534 IFEEAGCDTPASPSC 578
           IF EAG    ++P+C
Sbjct: 347 IFMEAGA-AISTPTC 360

[221][TOP]
>UniRef100_C4CHB6 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CHB6_9CHLR
          Length = 418

 Score =  119 bits (299), Expect = 1e-25
 Identities = 66/160 (41%), Positives = 93/160 (58%), Gaps = 2/160 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL  IG+I V GA Y  MEF G  +++L+M+ R+ + NM +EAG K G+   D  T ++L
Sbjct: 177 ILYTIGQIGVDGALYAVMEFTGEVIDALDMDGRIAMANMAIEAGAKTGIFACDDKTREWL 236

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
              T  PYE V SD  A +L    FDV+ L+P+VA PH P N   A E  D+ I++V IG
Sbjct: 237 ARVTDRPYEPVESDPDAEYLKVIEFDVSNLKPVVALPHLPSNVYPADEVGDMPIHQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKV 476
           SCT G+  D    AK+     G++V   V   ++P +Q+V
Sbjct: 297 SCTNGRISDLREVAKIL---KGRQVHPNVRCIVIPGSQEV 333

[222][TOP]
>UniRef100_Q1AVC5 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Rubrobacter
           xylanophilus DSM 9941 RepID=LEUC2_RUBXD
          Length = 424

 Score =  119 bits (299), Expect = 1e-25
 Identities = 68/194 (35%), Positives = 101/194 (52%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +I +I V G     +EFVG    SL++++R+ + NM VEAG + G+ P D VT +YL
Sbjct: 178 ILAVIADIGVGGGANAVLEFVGEGAASLSLDDRLAVANMAVEAGAETGIFPADEVTARYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           + +    +    SD  A ++ + + D+  LEPLVA PHSP N     E +  KI++VYIG
Sbjct: 238 DRRADREWHPERSDPDASYVRKVKIDLNSLEPLVALPHSPGNVVAVSEARGTKIDQVYIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           +C+ G   D    A++ L        V   +VPA+QKV+    S        +    +F 
Sbjct: 298 NCSNGTITDLRQTAEI-LRGNRVHPDVRAIIVPASQKVYRQAIS--------EGLIDVFV 348

Query: 543 EAGC--DTPASPSC 578
           EAG    TP   +C
Sbjct: 349 EAGAVVSTPTCGAC 362

[223][TOP]
>UniRef100_B9M5E2 Homoaconitate hydratase family protein n=1 Tax=Geobacter sp. FRC-32
           RepID=B9M5E2_GEOSF
          Length = 427

 Score =  119 bits (298), Expect = 2e-25
 Identities = 70/173 (40%), Positives = 96/173 (55%), Gaps = 12/173 (6%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG +TV GAT + MEF G+ V+S+ ME RMTLCNM +EAGG +G+  PDSVT  YL
Sbjct: 177 ILHVIGRLTVNGATDRVMEFRGAVVDSMTMESRMTLCNMAIEAGGTSGICMPDSVTVDYL 236

Query: 183 EGKTSVPYES----------VYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 332
               +  Y S           +SD+ A +      DV+ LEP+V   + PD      +  
Sbjct: 237 WPFINKEYASREAALADFKKWWSDEDATYDQVVDIDVSSLEPVVTFGYKPDQVKTIGDIA 296

Query: 333 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
              +++VY+GSCT G+ ED   AA +     GKK+   V   L PAT K++ D
Sbjct: 297 GTPVDQVYLGSCTNGRLEDLRIAAAIL---KGKKIASSVRAILSPATPKIYSD 346

[224][TOP]
>UniRef100_B8DM92 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           vulgaris str. 'Miyazaki F' RepID=LEUC_DESVM
          Length = 418

 Score =  119 bits (298), Expect = 2e-25
 Identities = 73/188 (38%), Positives = 107/188 (56%), Gaps = 4/188 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKY- 179
           IL++IGEI V GA Y+++EF G+ +E+L++E RMT+ NM +EAGGK G+   D+ T  Y 
Sbjct: 179 ILRLIGEIGVDGALYRALEFDGAAIEALSVEGRMTIANMAIEAGGKAGLFAADAKTLAYT 238

Query: 180 -LEGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVY 356
              G+   P   + +D  A +  E  FDV+ +EPLVA PH P+N     E + V +++V 
Sbjct: 239 AARGRKDAP---LSADPGATYERELTFDVSGMEPLVACPHLPENVKPVGEVRGVTLDQVV 295

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCS 530
           IGSCT G+  D   AA+V     G+KV   V   ++PAT  VW +           +   
Sbjct: 296 IGSCTNGRISDMREAAEVL---KGRKVAKGVRCIVLPATPGVWKEALK--------EGLI 344

Query: 531 QIFEEAGC 554
           + F E+GC
Sbjct: 345 ETFMESGC 352

[225][TOP]
>UniRef100_C8PKG7 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           gracilis RM3268 RepID=C8PKG7_9PROT
          Length = 421

 Score =  119 bits (297), Expect = 2e-25
 Identities = 74/197 (37%), Positives = 112/197 (56%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL++I  I V GA YK++EF G  +E L+M+ R +LCNM +EAGGK+G++  D +T ++L
Sbjct: 178 ILEVIRLIGVDGARYKALEFCGDALEYLDMDSRFSLCNMAIEAGGKSGIVAVDEITKEFL 237

Query: 183 EGKT-SVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRV 353
             K      +  YSD+ A +    + DV+KL+P++A P  P N    RE    D+ +++V
Sbjct: 238 ADKNLRAEPKFHYSDEGANYEQILQIDVSKLDPVIAYPFLPSNGKSVREAVRDDIAVDQV 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
           +IGSCT G+  D   AA++     G+KV  K    + PATQK+     +L     G    
Sbjct: 298 FIGSCTNGRLSDLRIAAQIL---KGRKVARKTRLIITPATQKI-----ALAAQKEG---L 346

Query: 528 SQIFEEAGCDTPASPSC 578
             IF EAG    ++P+C
Sbjct: 347 WDIFVEAGA-VVSNPTC 362

[226][TOP]
>UniRef100_A7VNU8 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753
           RepID=A7VNU8_9CLOT
          Length = 428

 Score =  119 bits (297), Expect = 2e-25
 Identities = 66/163 (40%), Positives = 92/163 (56%), Gaps = 2/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG I V GA Y+SMEF G  ++ L++++R+ + NM +EAG KNG+ P D VT  Y 
Sbjct: 179 ILHIIGMIGVDGALYQSMEFAGDGLQYLSIDDRLCIANMAIEAGAKNGIFPVDDVTRAYC 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+         +D+ A +  EY  D++ L P VA PH P+N         VKI++V IG
Sbjct: 239 NGRFQGTPVEYAADEDAVYEKEYVIDLSALRPTVAFPHLPENTRTIDNVGQVKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMD 485
           SCT G+  D   AA +     GKKV   V   + P TQ +++D
Sbjct: 299 SCTNGRLSDLRIAANLL---KGKKVAKNVRCIVFPGTQTIYLD 338

[227][TOP]
>UniRef100_Q74BX5 3-isopropylmalate dehydratase large subunit n=1 Tax=Geobacter
           sulfurreducens RepID=LEUC_GEOSL
          Length = 427

 Score =  119 bits (297), Expect = 2e-25
 Identities = 80/205 (39%), Positives = 107/205 (52%), Gaps = 13/205 (6%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GAT + MEF GS V+++ ME RMTLCNM +EAGG +G+  PD VT  YL
Sbjct: 177 ILHVIGRIGVNGATDRVMEFRGSVVDTMTMESRMTLCNMAIEAGGTSGICMPDMVTVDYL 236

Query: 183 EGKTSVPYES----------VYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 332
                  Y+S            SD+ A +     FDV+ LEP+V   + PD      E  
Sbjct: 237 WPFLKDEYQSREAALAAFSLWRSDEDAVYEQVLDFDVSSLEPIVTFGYKPDQVKPVSEIA 296

Query: 333 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVP 506
              +++VY+GSCT G+ ED   AA++     GKK+   V   L PAT K++ D       
Sbjct: 297 GTPVDQVYLGSCTNGRLEDLRIAARIL---KGKKIAPTVRGILSPATPKIYQDAMR---- 349

Query: 507 GSGGKTCSQIFEEAG-CDTPASPSC 578
               +    IF EAG C T  +P+C
Sbjct: 350 ----EGLIDIFMEAGFCVT--NPTC 368

[228][TOP]
>UniRef100_A7H0L8 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           curvus 525.92 RepID=LEUC_CAMC5
          Length = 421

 Score =  119 bits (297), Expect = 2e-25
 Identities = 75/197 (38%), Positives = 112/197 (56%), Gaps = 5/197 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II +I V GA YK++EF G T+++L+M+ R ++CNM +EAGGK+G+I  D  T ++L
Sbjct: 178 ILEIIRQIGVDGARYKALEFCGETIDALDMDGRFSMCNMAIEAGGKSGIIAVDETTREFL 237

Query: 183 EGKT-SVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRV 353
           +GK      +  YSD+ A +         KL+P++A P  P N    RE    D+ I++ 
Sbjct: 238 KGKNLRAEPKFFYSDEGAGYERVLEIYADKLDPVIAYPFLPSNGKSVREAVKDDIAIDQA 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPVPGSGGKTC 527
           +IGSCT G+  D   AA++     G+KV   T L+  PATQK+     +L     G    
Sbjct: 298 FIGSCTNGRLSDLRIAAEIL---KGRKVSRKTRLIITPATQKI-----ALAAQKEG---L 346

Query: 528 SQIFEEAGCDTPASPSC 578
             IF EAG    ++P+C
Sbjct: 347 MDIFVEAGA-VVSNPTC 362

[229][TOP]
>UniRef100_C5EVL2 Putative uncharacterized protein n=1 Tax=Clostridiales bacterium
           1_7_47FAA RepID=C5EVL2_9FIRM
          Length = 417

 Score =  118 bits (296), Expect = 3e-25
 Identities = 64/161 (39%), Positives = 93/161 (57%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA YKS+EF G  + SLNM++R ++CNMV+E+G KNG+ P D  T  YL
Sbjct: 179 ILTLIGMIGVDGARYKSIEFSGDGLHSLNMDDRFSICNMVIESGAKNGIFPVDEQTLDYL 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+   P+     D  A +  E   D+++L P+ A P  P N     E   ++I++  IG
Sbjct: 239 DGRVRRPFTIAAPDPDAVYSQEIVIDLSRLTPVAAGPSLPSNVKPVAEYYGIEIHQAVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SC+ G+  D  AAA V     G+KV   V   ++PAT  ++
Sbjct: 299 SCSNGRISDLRAAAAVM---KGEKVHPSVRCIIIPATPTIY 336

[230][TOP]
>UniRef100_C0C2K0 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0C2K0_9CLOT
          Length = 417

 Score =  118 bits (296), Expect = 3e-25
 Identities = 66/162 (40%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
 Frame = +3

Query: 6   LQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYLE 185
           L+ IG +  AGATY S+E+ G T+  L ++ERM + NM VE G K G++P D +T  YL+
Sbjct: 179 LRTIGTVGHAGATYMSVEYDGQTIRGLPVDERMAITNMAVEMGAKAGLMPFDDITEAYLD 238

Query: 186 GKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIGS 365
                 YE   SD  A F   Y+F   +L P VA PH  D    A   +DVKI + Y+GS
Sbjct: 239 SIGVKDYEPYQSDADASFYRTYQFRAEELRPQVACPHEVDRVTEADNVRDVKIQQAYLGS 298

Query: 366 CTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMD 485
           CTGG+  D   AA       GKKV   V   + PA++ +W +
Sbjct: 299 CTGGRLHDLKTAAAYL---KGKKVAPGVRLLISPASRSIWRE 337

[231][TOP]
>UniRef100_A0ZF76 3-isopropylmalate dehydratase, LeuC subunit n=1 Tax=Nodularia
           spumigena CCY9414 RepID=A0ZF76_NODSP
          Length = 574

 Score =  118 bits (296), Expect = 3e-25
 Identities = 65/176 (36%), Positives = 100/176 (56%), Gaps = 12/176 (6%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL I+G+I  AGAT K MEF GS +E +  +ER+TL NM +E G   G+I PD  T  Y+
Sbjct: 335 ILFILGQIGCAGATSKVMEFRGSILEQMPFDERLTLANMAIECGAICGLIVPDETTRNYV 394

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             ++   +E + +D  A +   Y+FD++ LEP +A+P  PD      + ++  I + +IG
Sbjct: 395 RSRSDQEFEELIADPDAEYEKVYKFDISNLEPQIARPPKPDQVVPISQIEETPITKAFIG 454

Query: 363 SCTGGKTEDFMAAAKVF----LASGGKKVKVPTFLVPATQKV--------WMDVYS 494
           SCTGGK  D   AA+V     +A G     V  F+VPA+ ++        +MD+++
Sbjct: 455 SCTGGKLYDLAQAAEVLQDRQVADG-----VNLFIVPASVEIREKAEALGYMDIFA 505

[232][TOP]
>UniRef100_C4CQ67 3-isopropylmalate dehydratase, large subunit n=1 Tax=Sphaerobacter
           thermophilus DSM 20745 RepID=C4CQ67_9CHLR
          Length = 424

 Score =  118 bits (295), Expect = 4e-25
 Identities = 65/161 (40%), Positives = 88/161 (54%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +I  I V G T   +EFVG    +L ++ER+ + NM VEAG + G+ P D VT  YL
Sbjct: 178 ILAVIDAIGVGGGTNTVLEFVGPGAAALTIDERLAVANMAVEAGAETGLFPADEVTAAYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
            G+T  P++   SD  A F    R D+  + PL+A PHSP N     E    KI++VYIG
Sbjct: 238 AGRTDRPWQPERSDPDASFARRVRIDLDGVPPLIALPHSPGNVVPVAEAAGRKIDQVYIG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           +C  G   D   AA + LA       V   +VPA+QKV+ +
Sbjct: 298 NCANGTMTDLRQAASI-LAGNRVHPDVRAIIVPASQKVYRE 337

[233][TOP]
>UniRef100_C0BZF9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM
           15053 RepID=C0BZF9_9CLOT
          Length = 431

 Score =  118 bits (295), Expect = 4e-25
 Identities = 74/199 (37%), Positives = 106/199 (53%), Gaps = 7/199 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           I+ IIG+I V GA YKSMEF G  + +L+M++R T+ NM +EAG KNG+   D     Y+
Sbjct: 185 IIHIIGKIGVDGALYKSMEFTGKGISNLSMDDRFTMANMAIEAGAKNGIFIVDEQAETYM 244

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARE---CKDVKINRV 353
           +  +   Y    +D+ A +      D++K+ P VA PH P N     E    + V+I++V
Sbjct: 245 KEHSDKSYTIYEADEDAVYDEVVEIDLSKVRPTVAFPHLPGNAKTIDEIEAMEPVRIDQV 304

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVPGSGGKTC 527
            IGSCT G+ ED   AA V     G KV   V   ++PATQK++    S        +  
Sbjct: 305 VIGSCTNGRMEDMRRAAAVL---KGHKVHPDVRAMIIPATQKIYKQCIS--------EGL 353

Query: 528 SQIFEEAGC--DTPASPSC 578
             IF +AGC  +TP+   C
Sbjct: 354 VDIFIDAGCAFNTPSCGPC 372

[234][TOP]
>UniRef100_B0NXK1 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1
           RepID=B0NXK1_9CLOT
          Length = 423

 Score =  118 bits (295), Expect = 4e-25
 Identities = 61/162 (37%), Positives = 94/162 (58%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L IIG +   G  YK MEF G    +L+++ER+ LCN+ VEAG K G++ PD    +Y+
Sbjct: 183 MLSIIGMVGANGCNYKIMEFAGEGAHNLDIDERLVLCNLAVEAGAKTGIVEPDEKVVEYV 242

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +         SD  A F   Y  ++ +++P+VA+PH  D+   A+E KDVKI+  ++G
Sbjct: 243 ESRGRKAENLFKSDDDAVFEKVYDINLDEIKPVVARPHQIDDVVDAKEVKDVKIDEAFLG 302

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWM 482
           SC  G+ E+   AA++     GKKV   V   + PA+ +V+M
Sbjct: 303 SCNNGRIEELRVAAEIL---KGKKVSDSVRFLIAPASNEVYM 341

[235][TOP]
>UniRef100_A1VAE7 3-isopropylmalate dehydratase large subunit n=1 Tax=Desulfovibrio
           vulgaris DP4 RepID=LEUC_DESVV
          Length = 419

 Score =  118 bits (295), Expect = 4e-25
 Identities = 72/186 (38%), Positives = 99/186 (53%), Gaps = 2/186 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA Y+++EF G+ +E+L++E RMT+ NM +EAGGK G+   D+ T  Y 
Sbjct: 179 ILTLIGAIGVDGALYRALEFDGAAIEALDVEGRMTMANMAIEAGGKAGLFAADAKTLTYC 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
                    +  +D  A +  E  FDVT + P+VA PH PDN     E KDV + +V IG
Sbjct: 239 TAAGRTGDAAFSADAGAVYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDVTVQQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AA V     G+KV   V   ++PAT  +W             +   + 
Sbjct: 299 SCTNGRIGDLREAAAVL---RGRKVSRDVRCIVLPATPGIWRQALR--------EGLIET 347

Query: 537 FEEAGC 554
           F EAGC
Sbjct: 348 FMEAGC 353

[236][TOP]
>UniRef100_A1HUD1 Homoaconitate hydratase family protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HUD1_9FIRM
          Length = 419

 Score =  117 bits (293), Expect = 6e-25
 Identities = 64/161 (39%), Positives = 94/161 (58%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+ I EI  AGATYK MEF GS +E+L+++ERMT+ NM VEAG K G++ PD   + YL
Sbjct: 178 ILRTIKEIGQAGATYKVMEFAGSCIENLSVDERMTIANMAVEAGAKTGLMAPDDKVFAYL 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E   +     +YSD  A +  ++ F+   L P +A PH  D      E +   I++ Y+G
Sbjct: 238 ESIGAPKGTPLYSDPDAEYAQKFEFNADTLVPQIALPHEVDKVVDITEAEGEVIHQAYLG 297

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVW 479
           SCT G+  D + AAK+     G+KV   V   + PA++ ++
Sbjct: 298 SCTNGRYPDLVEAAKIL---KGRKVHPDVRLLVSPASRSIY 335

[237][TOP]
>UniRef100_B2KBD7 3-isopropylmalate dehydratase large subunit n=1 Tax=Elusimicrobium
           minutum Pei191 RepID=LEUC_ELUMP
          Length = 418

 Score =  117 bits (293), Expect = 6e-25
 Identities = 66/163 (40%), Positives = 96/163 (58%), Gaps = 3/163 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I   GATYK++EF GST+ ++ M +R TL NM VEAG K G+   D  T  YL
Sbjct: 175 ILHLIGVIGADGATYKALEFHGSTIRNMEMADRFTLANMAVEAGAKAGLFFTDEKTRAYL 234

Query: 183 -EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYI 359
            E      ++ + +D+ A +    + D + LEP V+ PH+ DN     E KD+K+N+V+I
Sbjct: 235 AERGRGDNFKLISADEGADYEKVIKIDASSLEPTVSCPHTVDNTKTVGELKDIKVNQVFI 294

Query: 360 GSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           G+CT G+ ED   AA++      KKV     TF+ PA++ V +
Sbjct: 295 GTCTNGRIEDLRIAAEIL---KDKKVNPGTRTFITPASRDVML 334

[238][TOP]
>UniRef100_Q726X4 3-isopropylmalate dehydratase large subunit n=2 Tax=Desulfovibrio
           vulgaris RepID=LEUC_DESVH
          Length = 419

 Score =  117 bits (293), Expect = 6e-25
 Identities = 72/186 (38%), Positives = 99/186 (53%), Gaps = 2/186 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG I V GA Y+++EF G+ +E+L++E RMT+ NM +EAGGK G+   D+ T  Y 
Sbjct: 179 ILTLIGAIGVDGALYRALEFDGAAIEALDVEGRMTMANMAIEAGGKAGLFAADAKTLTYC 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
                    +  +D  A +  E  FDVT + P+VA PH PDN     E KDV + +V IG
Sbjct: 239 TTAGRTGDTAFSADAGAVYERELSFDVTGMTPVVACPHLPDNVKPVSEVKDVTVQQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCSQI 536
           SCT G+  D   AA V     G+KV   V   ++PAT  +W             +   + 
Sbjct: 299 SCTNGRIGDLREAAAVL---RGRKVSRDVRCIVLPATPGIWRQALR--------EGLIET 347

Query: 537 FEEAGC 554
           F EAGC
Sbjct: 348 FMEAGC 353

[239][TOP]
>UniRef100_UPI0001979722 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI0001979722
          Length = 420

 Score =  117 bits (292), Expect = 8e-25
 Identities = 57/161 (35%), Positives = 95/161 (59%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEF G  +++L +++R+ + NM +EAG KNG+   D +T +Y 
Sbjct: 179 ILHIIGKIGVDGALYKSMEFSGEGLKNLTIDDRLCIANMAIEAGAKNGIFEVDDITIEYA 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+TS  +    +D+ A +   +  ++  ++  VA PH P+N     +  ++KI++V IG
Sbjct: 239 KGRTSKEFRIYKADEDAEYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           SCT G+  D   AA +       K      ++PATQ ++++
Sbjct: 299 SCTNGRLSDMEVAANILKDKTIAK-NTRCIIIPATQNIYLE 338

[240][TOP]
>UniRef100_Q3AD33 3-isopropylmalate dehydratase, large subunit family protein n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AD33_CARHZ
          Length = 417

 Score =  117 bits (292), Expect = 8e-25
 Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 2/194 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG++T  GATY + E+ G  +  L+M+ R T+ NM +E G K G++  D  T+ ++
Sbjct: 176 ILYLIGDVTADGATYMAAEYTGEAISDLSMDGRFTIANMAIEMGAKAGLMEADEKTFAFV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +      +  V++D  A +     +DV++LEP+VAKPH+ DN A   E     I++  +G
Sbjct: 236 KEHGGKDFTPVFADPDAVYAKVLEYDVSELEPMVAKPHTVDNTARVTEVAGTPIHQAVLG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV--PATQKVWMDVYSLPVPGSGGKTCSQI 536
           +CT G+ ED   AAK+     G+K+   T L+  PA++K+++            +   +I
Sbjct: 296 TCTNGRLEDLRIAAKIL---EGRKIHPRTRLIVAPASRKIFLKAME--------EGLIKI 344

Query: 537 FEEAGCDTPASPSC 578
           F EAG     +P C
Sbjct: 345 FVEAGA-AVVTPGC 357

[241][TOP]
>UniRef100_C3XG48 3-isopropylmalate dehydratase large subunit n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XG48_9HELI
          Length = 420

 Score =  117 bits (292), Expect = 8e-25
 Identities = 57/161 (35%), Positives = 95/161 (59%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG+I V GA YKSMEF G  +++L +++R+ + NM +EAG KNG+   D +T +Y 
Sbjct: 179 ILHIIGKIGVDGALYKSMEFSGEGLKNLTIDDRLCIANMAIEAGAKNGIFEVDDITIEYA 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+TS  +    +D+ A +   +  ++  ++  VA PH P+N     +  ++KI++V IG
Sbjct: 239 KGRTSKEFRIYKADEDAEYEEVFDIELDSIDHTVAFPHLPENTKEREQWGEIKIDQVVIG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMD 485
           SCT G+  D   AA +       K      ++PATQ ++++
Sbjct: 299 SCTNGRLSDMEVAANILKDKTIAK-NTRCIIIPATQNIYLE 338

[242][TOP]
>UniRef100_A5G7U4 3-isopropylmalate dehydratase large subunit n=1 Tax=Geobacter
           uraniireducens Rf4 RepID=LEUC_GEOUR
          Length = 427

 Score =  117 bits (292), Expect = 8e-25
 Identities = 76/205 (37%), Positives = 109/205 (53%), Gaps = 13/205 (6%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL +IG + V GAT + +EF G+ V+++ ME RMTLCNM +EAGG +G+  PDSVT  YL
Sbjct: 177 ILHVIGRLGVNGATDRVIEFRGAVVDAMTMESRMTLCNMAIEAGGTSGICMPDSVTVDYL 236

Query: 183 ----------EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECK 332
                     +    V ++  +SD+ A +      D++ LEP+V   + PD      E  
Sbjct: 237 WPFISEDYASKEAALVEFKKWWSDEDAVYERVLDLDISGLEPVVTFGYKPDQVKTITEMA 296

Query: 333 DVKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKVWMDVYSLPVP 506
              +++VY+GSCT G+ ED   AA++     GKK+   V   L PAT KV+ D       
Sbjct: 297 GTPVDQVYLGSCTNGRLEDLRVAAEIL---KGKKIAPTVRAILSPATPKVYSDALH---- 349

Query: 507 GSGGKTCSQIFEEAG-CDTPASPSC 578
               +    IF EAG C T  +P+C
Sbjct: 350 ----EGLIDIFMEAGFCVT--NPTC 368

[243][TOP]
>UniRef100_A7ZFP0 3-isopropylmalate dehydratase large subunit n=1 Tax=Campylobacter
           concisus 13826 RepID=LEUC_CAMC1
          Length = 421

 Score =  117 bits (292), Expect = 8e-25
 Identities = 64/163 (39%), Positives = 99/163 (60%), Gaps = 5/163 (3%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL+II +I V GA YK++EF G  ++ L+M++R ++CNM +EAG K+G+I  D +T ++L
Sbjct: 178 ILEIIRQIGVDGALYKALEFSGEVIDGLSMDDRFSMCNMAIEAGAKSGIIAVDEITKEFL 237

Query: 183 EGKT-SVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALAREC--KDVKINRV 353
           + K      +  YSD+ A++      DVT L+P++A P  P N    R+    D+ I++ 
Sbjct: 238 KDKNLRDKPKFFYSDEGAKYDKILEIDVTNLDPVIAYPFLPSNGKSVRQAVRDDLAIDQA 297

Query: 354 YIGSCTGGKTEDFMAAAKVFLASGGKKV--KVPTFLVPATQKV 476
           +IGSCT G+  D   AA++     GKKV  K    + PATQK+
Sbjct: 298 FIGSCTNGRLSDLRIAAQIL---KGKKVARKTRLIITPATQKI 337

[244][TOP]
>UniRef100_C0WAT0 3-isopropylmalate dehydratase n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WAT0_9FIRM
          Length = 418

 Score =  116 bits (291), Expect = 1e-24
 Identities = 70/192 (36%), Positives = 101/192 (52%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L +IG I V GA Y+S+EF G  +  L+M +R T+ NM +EAG KNG+ P D  T  Y 
Sbjct: 178 MLTLIGMIGVDGALYQSLEFTGDGIAELSMTDRFTMANMAIEAGAKNGIFPVDEKTKAYE 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +G+    YE V +D  A +      D+T L P+VA PH P N        D+ I++V IG
Sbjct: 238 QGRVE-DYEIVTADSDAVYKRTVTIDLTALTPVVAFPHLPGNTKAIGTFGDIPIDQVVIG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCT G+ ED   AAK+ L        V   ++P +Q+V+ +           K     F 
Sbjct: 297 SCTNGRLEDLAIAAKI-LEGRTVHPDVRCIVIPGSQEVYKEAMK--------KGYIDTFI 347

Query: 543 EAGCDTPASPSC 578
           +AGC   ++P+C
Sbjct: 348 DAGC-VVSTPTC 358

[245][TOP]
>UniRef100_B0MIT8 Putative uncharacterized protein n=1 Tax=Anaerostipes caccae DSM
           14662 RepID=B0MIT8_9FIRM
          Length = 413

 Score =  116 bits (291), Expect = 1e-24
 Identities = 60/162 (37%), Positives = 92/162 (56%), Gaps = 2/162 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG +   G  YK MEF G    +L++ ER+ LCN+ VEAG K G++ PD    +Y+
Sbjct: 176 ILSIIGMVGANGCNYKIMEFAGEGAHNLSINERLVLCNLAVEAGAKTGIVEPDEKVVEYV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +         SD+ ARF   Y  ++ ++EP+VA+PH  D+     E  DVKI+  ++G
Sbjct: 236 ESRGRKAENLFVSDEDARFEKVYHINLDEIEPVVARPHLIDDVVPVEEAGDVKIDEAFLG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWM 482
           SC  G+ ++   AA++     GKKV   V   + PA+ +V++
Sbjct: 296 SCNNGRIDELRLAAEIL---KGKKVHEGVRFLIAPASNEVYV 334

[246][TOP]
>UniRef100_B9AFU3 Putative uncharacterized protein n=1 Tax=Methanobrevibacter smithii
           DSM 2375 RepID=B9AFU3_METSM
          Length = 414

 Score =  116 bits (291), Expect = 1e-24
 Identities = 64/161 (39%), Positives = 98/161 (60%), Gaps = 2/161 (1%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           IL IIG++   G+TYK+ EF G TV  +++ +RM L NM +E GGK G++  D  T  Y+
Sbjct: 178 ILNIIGQMGADGSTYKACEFAGETVSDMSISDRMVLTNMAIEMGGKTGLVEVDKKTIDYV 237

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           E +++ PY+   +D  A  L+    DV+ LEP VA PH+ DN     E  D +I++V++G
Sbjct: 238 ESRSNKPYKVFKTDLDAPSLNIIDIDVSDLEPQVACPHNVDNVKPVSEV-DEEIDQVFLG 296

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPT--FLVPATQKVW 479
           SCT G+  D   AAK+     GKK+   T   ++PA+++V+
Sbjct: 297 SCTNGRLSDLRDAAKIL---KGKKIAKGTRMLVIPASKEVY 334

[247][TOP]
>UniRef100_Q1IZK5 3-isopropylmalate dehydratase large subunit n=1 Tax=Deinococcus
           geothermalis DSM 11300 RepID=Q1IZK5_DEIGD
          Length = 431

 Score =  116 bits (290), Expect = 1e-24
 Identities = 72/196 (36%), Positives = 102/196 (52%), Gaps = 4/196 (2%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L++I  I   GA Y  ME+VG T+E ++ME R TL NM +EAGGK G++  D  T  Y+
Sbjct: 179 VLEVIRRIGADGANYLVMEWVGDTIERMDMEGRFTLTNMAIEAGGKTGIVAVDDTTRAYM 238

Query: 183 --EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVY 356
              G T   Y    SD  AR+      D +K+EP VA PH P N  +A + + + I   Y
Sbjct: 239 AARGVTPDQYTEYTSDPDARYKVVIDLDASKVEPTVAYPHIPSNGRVAGQDR-IPITHAY 297

Query: 357 IGSCTGGKTEDFMAAAKVFLASGGKKVK--VPTFLVPATQKVWMDVYSLPVPGSGGKTCS 530
           +GSCT G+  D    A++     G++V   V   +VPATQ +W          +  +   
Sbjct: 298 VGSCTNGRIGDLRDVARIL---KGRRVADGVQMIVVPATQAIWKQ--------AAQEGLL 346

Query: 531 QIFEEAGCDTPASPSC 578
           +IF EAG    + PSC
Sbjct: 347 EIFVEAGASV-SYPSC 361

[248][TOP]
>UniRef100_C7LW15 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LW15_DESBD
          Length = 420

 Score =  116 bits (290), Expect = 1e-24
 Identities = 60/152 (39%), Positives = 86/152 (56%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L  IG+  VAGA YK++EF G  +E L++E RMT+ NM +EAGGK G+   D  T  Y 
Sbjct: 179 VLFTIGQTGVAGALYKALEFGGEIIEGLSVEARMTMANMAIEAGGKAGLFAADEKTLAYC 238

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
           +    +    + +D+ A +  E  FDV+   P +A PH PDN     E  DV++++V +G
Sbjct: 239 QAHGRMGDSPIAADEGAHYWKEMTFDVSSFSPQIACPHLPDNVRPVEEVSDVRVDQVVLG 298

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLV 458
           SCT G+  D   AAK+    G K  K   F+V
Sbjct: 299 SCTNGRISDLREAAKII--KGRKVAKGVRFIV 328

[249][TOP]
>UniRef100_C4EWE6 3-isopropylmalate dehydratase, large subunit n=1
           Tax=Thermanaerovibrio acidaminovorans DSM 6589
           RepID=C4EWE6_9BACT
          Length = 417

 Score =  116 bits (290), Expect = 1e-24
 Identities = 74/192 (38%), Positives = 105/192 (54%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L IIG + V GA Y+++EF G  V SL+M+ RMT+ NM +E G K  +  PD  T  Y+
Sbjct: 176 MLHIIGTLGVDGARYRALEFHGDGVRSLSMDGRMTMANMGIECGAKAALFVPDEATLAYV 235

Query: 183 EGKTSVPYESVYSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKDVKINRVYIG 362
             +    +E VY D  A +  E    +  L PLVA P+ P N   ARE +DV+I++V+IG
Sbjct: 236 APRARRSFEPVYPDPGAAYERELTVRLDSLPPLVACPNLPSNVRPARELRDVEIHQVFIG 295

Query: 363 SCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWMDVYSLPVPGSGGKTCSQIFE 542
           SCT G+ ED   AAKV L        V   L+PA+++   D+ +    G       ++F 
Sbjct: 296 SCTNGRIEDLRQAAKV-LKGRRLHPSVRGVLIPASRR---DMAAAMQEG-----LMEVFM 346

Query: 543 EAGCDTPASPSC 578
           EAG     +PSC
Sbjct: 347 EAGFSI-CTPSC 357

[250][TOP]
>UniRef100_Q58409 Homoaconitase large subunit n=1 Tax=Methanocaldococcus jannaschii
           RepID=HACA_METJA
          Length = 420

 Score =  116 bits (290), Expect = 1e-24
 Identities = 61/169 (36%), Positives = 97/169 (57%), Gaps = 9/169 (5%)
 Frame = +3

Query: 3   ILQIIGEITVAGATYKSMEFVGSTVESLNMEERMTLCNMVVEAGGKNGVIPPDSVTYKYL 182
           +L++  EI   GATY ++E+ G  V++++M+ R+TLCNM +E GGK GVI  D +TY YL
Sbjct: 172 VLRVCKEIGRRGATYMAIEYGGEVVKNMDMDGRLTLCNMAIEMGGKTGVIEADEITYDYL 231

Query: 183 EGKTSVPYESV---------YSDQQARFLSEYRFDVTKLEPLVAKPHSPDNRALARECKD 335
           + +  +  E +          +  +A +  E   D+T +E  VA PH PDN     + + 
Sbjct: 232 KKERGLSDEDIAKLKKERITVNRDEANYYKEIEIDITDMEEQVAVPHHPDNVKPISDVEG 291

Query: 336 VKINRVYIGSCTGGKTEDFMAAAKVFLASGGKKVKVPTFLVPATQKVWM 482
            +IN+V+IGSCT G+  D   AAK +L        V   ++PA++KV++
Sbjct: 292 TEINQVFIGSCTNGRLSDLREAAK-YLKGREVHKDVKLIVIPASKKVFL 339