[UP]
[1][TOP] >UniRef100_Q54WT3 Putative uncharacterized protein n=1 Tax=Dictyostelium discoideum RepID=Q54WT3_DICDI Length = 864 Score = 89.4 bits (220), Expect = 2e-16 Identities = 67/187 (35%), Positives = 92/187 (49%), Gaps = 13/187 (6%) Frame = +2 Query: 14 CSATKA--CCSKLNTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPD 187 CSA+ C N DNC F L +GDGS +G LVIDN+T G T P FG I K+S Sbjct: 232 CSASVCNNSCQNKNHDNCPFMLKYGDGSFIAGSLVIDNVTIG-QFTVPAKFGNIQKESLS 290 Query: 188 FERSTV----------DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITGTGG 337 F + T DGILGL++ +L +P + F +V I N+FSMC+ GG Sbjct: 291 FSQLTCPSNARSQAVRDGILGLSFQEL--DPYNGDDIFSKIVSSYGIPNVFSMCLGKDGG 348 Query: 338 KLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELP-PLRKGIVDSG 514 L +GG + + P + P++ YY V + + + P IVDSG Sbjct: 349 ILTIGGINERVNIETPKYTPII---DFHYYSIHVLN-IYVENESLKFTPNDFISSIVDSG 404 Query: 515 TTLIVFS 535 TTL+ F+ Sbjct: 405 TTLLYFN 411 [2][TOP] >UniRef100_Q4T859 Chromosome undetermined SCAF7887, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T859_TETNG Length = 472 Score = 68.9 bits (167), Expect = 2e-10 Identities = 60/164 (36%), Positives = 81/164 (49%), Gaps = 22/164 (13%) Frame = +2 Query: 101 GELVID--NLTWGNNITFPVVFGGILKDS----PDFERSTVDGILGLAWPKLACNPSCVE 262 GEL +D ++ G N T P+ IL PD GILGLA+P LA S V Sbjct: 91 GELGVDLVSMPTGPNGTVPINIAAILSSDGFFLPDIHWQ---GILGLAYPLLARPDSSVT 147 Query: 263 PTFDAMVRHLKIDNIFSMCITGT------------GGKLVLGGHDTTLAKADPVWVPMVL 406 P FD++VR L I ++FS+ + G GG L++GG + TL + PVW ++ Sbjct: 148 PFFDSLVRQLGIPDVFSLQMCGAGLSAGAAAAAALGGSLIMGGTEPTLHRG-PVWYTPIV 206 Query: 407 RSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLI 526 YY +V L +GD+ D E K IVDSGTTL+ Sbjct: 207 EE--WYYQVEVL-KLEVGDQNLDLDCREY-NTDKAIVDSGTTLL 246 [3][TOP] >UniRef100_UPI0000F2CC7E PREDICTED: similar to aspartic-like protease n=1 Tax=Monodelphis domestica RepID=UPI0000F2CC7E Length = 534 Score = 67.0 bits (162), Expect = 9e-10 Identities = 64/180 (35%), Positives = 94/180 (52%), Gaps = 18/180 (10%) Frame = +2 Query: 38 SKLNTDNCGFHLSFGDGS--GASGELVIDNLTWGNNITFPVVFGGILKDSPDF--ERSTV 205 S + N ++ + GS G+ GE ++ + G N TF V I+ +S DF ++ Sbjct: 152 STYRSKNLNINVKYTQGSWTGSVGEDMV-TIPKGFNSTFLVNIA-IIFESKDFFLPKTKW 209 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFS--MCITG--------TGGKLVLGG 355 DGILGLA+ LA S +E FD++V+ +KI NIFS MC G +GG LV+GG Sbjct: 210 DGILGLAYAMLAKPSSSLETFFDSLVKQVKIPNIFSIQMCGAGLPRDKTGTSGGSLVMGG 269 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L + D +W + + YY ++ L IG + D E + K IVDSGTTL Sbjct: 270 IEPSLYEGD-IWYTSIKKE--WYYQIEIL-KLEIGGQSLNLDCIEY-NVDKAIVDSGTTL 324 [4][TOP] >UniRef100_UPI00016E3722 UPI00016E3722 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E3722 Length = 406 Score = 66.2 bits (160), Expect = 2e-09 Identities = 60/169 (35%), Positives = 84/169 (49%), Gaps = 18/169 (10%) Frame = +2 Query: 98 SGELVID--NLTWGNNITFPVVFGGILKDSPDFERS-TVDGILGLAWPKLACNPSCVEPT 268 +GEL +D ++ G N TFP+ IL F GILGLA+P LA V P Sbjct: 96 NGELGMDLVSIPEGPNGTFPINIAAILSSEGFFLPDINWQGILGLAYPLLARPDPSVTPF 155 Query: 269 FDAMVRHLKIDNIFS--MC---------ITGTGGKLVLGGHDTTLAKADPVWVPMVLRSP 415 FD++V+ L I +IFS MC + GG L++GG ++TL PVW ++ Sbjct: 156 FDSLVQQLGIPDIFSLQMCGAGLSASSTVDAAGGSLIMGGTESTL-YTGPVWYTPIVEE- 213 Query: 416 PSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQHYWN 550 YY +V L +G++ D E K IVDSGTTL+ + +N Sbjct: 214 -WYYQVEVL-KLEVGNQNLELDCKEY-NTDKAIVDSGTTLLRLPVNVFN 259 [5][TOP] >UniRef100_UPI00016E3721 UPI00016E3721 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E3721 Length = 505 Score = 66.2 bits (160), Expect = 2e-09 Identities = 60/169 (35%), Positives = 84/169 (49%), Gaps = 18/169 (10%) Frame = +2 Query: 98 SGELVID--NLTWGNNITFPVVFGGILKDSPDFERS-TVDGILGLAWPKLACNPSCVEPT 268 +GEL +D ++ G N TFP+ IL F GILGLA+P LA V P Sbjct: 145 NGELGMDLVSIPEGPNGTFPINIAAILSSEGFFLPDINWQGILGLAYPLLARPDPSVTPF 204 Query: 269 FDAMVRHLKIDNIFS--MC---------ITGTGGKLVLGGHDTTLAKADPVWVPMVLRSP 415 FD++V+ L I +IFS MC + GG L++GG ++TL PVW ++ Sbjct: 205 FDSLVQQLGIPDIFSLQMCGAGLSASSTVDAAGGSLIMGGTESTL-YTGPVWYTPIVEE- 262 Query: 416 PSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQHYWN 550 YY +V L +G++ D E K IVDSGTTL+ + +N Sbjct: 263 -WYYQVEVL-KLEVGNQNLELDCKEY-NTDKAIVDSGTTLLRLPVNVFN 308 [6][TOP] >UniRef100_UPI00016E3720 UPI00016E3720 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E3720 Length = 504 Score = 66.2 bits (160), Expect = 2e-09 Identities = 60/169 (35%), Positives = 84/169 (49%), Gaps = 18/169 (10%) Frame = +2 Query: 98 SGELVID--NLTWGNNITFPVVFGGILKDSPDFERS-TVDGILGLAWPKLACNPSCVEPT 268 +GEL +D ++ G N TFP+ IL F GILGLA+P LA V P Sbjct: 144 NGELGMDLVSIPEGPNGTFPINIAAILSSEGFFLPDINWQGILGLAYPLLARPDPSVTPF 203 Query: 269 FDAMVRHLKIDNIFS--MC---------ITGTGGKLVLGGHDTTLAKADPVWVPMVLRSP 415 FD++V+ L I +IFS MC + GG L++GG ++TL PVW ++ Sbjct: 204 FDSLVQQLGIPDIFSLQMCGAGLSASSTVDAAGGSLIMGGTESTL-YTGPVWYTPIVEE- 261 Query: 416 PSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQHYWN 550 YY +V L +G++ D E K IVDSGTTL+ + +N Sbjct: 262 -WYYQVEVL-KLEVGNQNLELDCKEY-NTDKAIVDSGTTLLRLPVNVFN 307 [7][TOP] >UniRef100_B8YJG0 Syncephapepsin n=1 Tax=Syncephalastrum racemosum RepID=B8YJG0_SYNRA Length = 394 Score = 63.5 bits (153), Expect = 1e-08 Identities = 50/183 (27%), Positives = 81/183 (44%), Gaps = 4/183 (2%) Frame = +2 Query: 2 SCGKCSATKACCSKLNTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS 181 SCG S S + +S+GDGS ASG DN+ G ++S Sbjct: 121 SCGSKSFDPTKSSTYKKVGKSWQISYGDGSSASGITATDNVELGGLTITGQTIELATRES 180 Query: 182 PDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGGKLVL 349 F +DGILGL + +A P + + ++L IF + + G GG+ V Sbjct: 181 SSFSTGAIDGILGLGFDTIATVAGTKTPVDNLISQNLISKPIFGVWLGKQSEGGGGEYVF 240 Query: 350 GGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 GG++T D + + + +Y V+G L++G + GI+D+GTTL++ Sbjct: 241 GGYNTD--HIDGSLTTVKVDNSQGWYGVTVSG-LKVGSKSVAS---SFDGILDTGTTLLI 294 Query: 530 FSQ 538 F + Sbjct: 295 FDR 297 [8][TOP] >UniRef100_P81214 Syncephapepsin n=1 Tax=Syncephalastrum racemosum RepID=CARP_SYNRA Length = 395 Score = 63.2 bits (152), Expect = 1e-08 Identities = 50/183 (27%), Positives = 81/183 (44%), Gaps = 4/183 (2%) Frame = +2 Query: 2 SCGKCSATKACCSKLNTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS 181 SCG S S + +S+GDGS ASG DN+ G ++S Sbjct: 122 SCGSKSFDPTKSSTYKKVGKSWQISYGDGSSASGITATDNVELGGLKITGQTIELATRES 181 Query: 182 PDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGGKLVL 349 F +DGILGL + ++ P + + ++L IF + + G GG+ V Sbjct: 182 SSFSSGAIDGILGLGFDTISTVAGTKTPVDNLISQNLISKPIFGVWLGKQSEGGGGEYVF 241 Query: 350 GGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 GG++T D + + + +Y V+G L++G + GI+D+GTTL++ Sbjct: 242 GGYNTD--HIDGSLTTVKVDNSQGWYGVTVSG-LKVGSKSVAS---SFDGILDTGTTLLI 295 Query: 530 FSQ 538 F Q Sbjct: 296 FDQ 298 [9][TOP] >UniRef100_UPI0000EBC1E1 PREDICTED: similar to beta-site APP-cleaving enzyme 2 isoform C preproprotein isoform 1 n=1 Tax=Bos taurus RepID=UPI0000EBC1E1 Length = 464 Score = 62.0 bits (149), Expect = 3e-08 Identities = 62/169 (36%), Positives = 82/169 (48%), Gaps = 16/169 (9%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTV--DGILGLAWPKLACNPS 253 G +G GE V+ + G N +F V I +S +F + +GILGLA+ LA S Sbjct: 148 GSWTGFVGEDVV-TIPKGFNSSFLVNIATIF-ESENFFLPGIRWNGILGLAYATLAKPSS 205 Query: 254 CVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGHDTTLAKADPVWVPMV 403 +E FD++V KI NIFSM + G GG LVLGG + TL K D + P+ Sbjct: 206 SLETFFDSLVAQAKIPNIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPTLYKGDIWYTPI- 264 Query: 404 LRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQ 538 YY ++ L IG + D E K IVDSGTTL+ Q Sbjct: 265 --KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTLLRLPQ 309 [10][TOP] >UniRef100_UPI0000EBC1E0 PREDICTED: similar to beta-site APP-cleaving enzyme 2 isoform C preproprotein isoform 2 n=2 Tax=Bos taurus RepID=UPI0000EBC1E0 Length = 514 Score = 62.0 bits (149), Expect = 3e-08 Identities = 62/169 (36%), Positives = 82/169 (48%), Gaps = 16/169 (9%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTV--DGILGLAWPKLACNPS 253 G +G GE V+ + G N +F V I +S +F + +GILGLA+ LA S Sbjct: 148 GSWTGFVGEDVV-TIPKGFNSSFLVNIATIF-ESENFFLPGIRWNGILGLAYATLAKPSS 205 Query: 254 CVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGHDTTLAKADPVWVPMV 403 +E FD++V KI NIFSM + G GG LVLGG + TL K D + P+ Sbjct: 206 SLETFFDSLVAQAKIPNIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPTLYKGDIWYTPI- 264 Query: 404 LRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQ 538 YY ++ L IG + D E K IVDSGTTL+ Q Sbjct: 265 --KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTLLRLPQ 309 [11][TOP] >UniRef100_O60020 Aspartic protease n=1 Tax=Xanthophyllomyces dendrorhous RepID=O60020_PHARH Length = 405 Score = 62.0 bits (149), Expect = 3e-08 Identities = 44/154 (28%), Positives = 69/154 (44%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTVDGILGLAWPKLAC 244 F +S+GDGS ASG + DN+ VFG + +S F DGI GL WP LA Sbjct: 150 FSISYGDGSSASGPVYKDNVVASGLQATSQVFGAVTSESSSFSSDPSDGISGLGWPALA- 208 Query: 245 NPSCVEPTFDAMVRHLKIDNIFSMCITGTGGKLVLGGHDTTLAKADPVWVPMVLRSPPSY 424 S + + + +FS + T +L LGG ++ + P+ + +Y Sbjct: 209 QLSGTSYFWSLINQGTVTSPVFSFRLATTNSELYLGGINSAHYTGAITYTPVTQK---AY 265 Query: 425 YPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 + + G + A P + I+D+GTTL+ Sbjct: 266 WTIALGG---VSVNGAAINPSVSSAIIDTGTTLV 296 [12][TOP] >UniRef100_B3MSE4 GF19752 n=1 Tax=Drosophila ananassae RepID=B3MSE4_DROAN Length = 405 Score = 61.6 bits (148), Expect = 4e-08 Identities = 52/175 (29%), Positives = 91/175 (52%), Gaps = 8/175 (4%) Frame = +2 Query: 38 SKLNTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGI 214 S ++ F++++G GS SG + D +T + +FG + +S +F+ + DGI Sbjct: 123 STYQSNGTAFNITYGTGS-VSGFMSQDVVTVAGLSSTNQIFGEVTTESGSNFQSAYFDGI 181 Query: 215 LGLAWPKLACNPSCVEPTFDAMVRHLKIDN-IFSM------CITGTGGKLVLGGHDTTLA 373 LG+A+P LA + V P F ++ + +++ +FS I GG+L+LGG D +L Sbjct: 182 LGMAFPSLAAD--LVTPFFQNLISNGEVEQPVFSFYLRDNGSIVNYGGELILGGSDPSLY 239 Query: 374 KADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQ 538 + +VP+ S P Y+ F T + +G+ T + I D+GT+L+V Q Sbjct: 240 SGELTYVPV---SYPQYWQF-YTDAILLGN---TLISMGDVAIADTGTSLLVAPQ 287 [13][TOP] >UniRef100_Q9DEX3 Cathepsin D n=1 Tax=Clupea harengus RepID=CATD_CLUHA Length = 396 Score = 61.2 bits (147), Expect = 5e-08 Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 7/161 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKD-SPDFERSTVDGILGLAWPKLA 241 F + +G GS SG L D+ T G+ + +FG +K F + DGILG+A+P+++ Sbjct: 135 FAIQYGSGS-LSGYLSQDSCTIGDIVVEKQLFGEAIKQPGVAFIAAKFDGILGMAYPRIS 193 Query: 242 CNPSCVEPTFDAMVRHLKID-NIFSMCI-----TGTGGKLVLGGHDTTLAKADPVWVPMV 403 + V P FD M+ K++ N+FS + T GG+L+LGG D D +VP+ Sbjct: 194 VDG--VPPVFDMMMSQKKVEQNVFSFYLNRNPDTEPGGELLLGGTDPKYYTGDFNYVPVT 251 Query: 404 LRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 + +Y+ + G + IG + T + IVD+GT+LI Sbjct: 252 RQ---AYWQIHMDG-MSIGSQ-LTLCKDGCEAIVDTGTSLI 287 [14][TOP] >UniRef100_UPI00005A53E5 PREDICTED: similar to beta-site APP-cleaving enzyme 2 isoform A preproprotein n=1 Tax=Canis lupus familiaris RepID=UPI00005A53E5 Length = 422 Score = 60.8 bits (146), Expect = 6e-08 Identities = 49/129 (37%), Positives = 65/129 (50%), Gaps = 14/129 (10%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V KI N+FSM + G GG LVLGG Sbjct: 98 NGILGLAYAALAKPSSSLETFFDSLVAQAKIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 157 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 158 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 212 Query: 524 IVFSQHYWN 550 + Q +N Sbjct: 213 LRLPQKVFN 221 [15][TOP] >UniRef100_UPI0000EB06B9 Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Aspartic-like protease 56 kDa) (Down region aspartic protease). n=1 Tax=Canis lupus familiaris RepID=UPI0000EB06B9 Length = 312 Score = 60.8 bits (146), Expect = 6e-08 Identities = 49/129 (37%), Positives = 65/129 (50%), Gaps = 14/129 (10%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V KI N+FSM + G GG LVLGG Sbjct: 73 NGILGLAYAALAKPSSSLETFFDSLVAQAKIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 132 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 133 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 187 Query: 524 IVFSQHYWN 550 + Q +N Sbjct: 188 LRLPQKVFN 196 [16][TOP] >UniRef100_UPI0000EB06B8 Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Aspartic-like protease 56 kDa) (Down region aspartic protease). n=1 Tax=Canis lupus familiaris RepID=UPI0000EB06B8 Length = 365 Score = 60.8 bits (146), Expect = 6e-08 Identities = 49/129 (37%), Positives = 65/129 (50%), Gaps = 14/129 (10%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V KI N+FSM + G GG LVLGG Sbjct: 91 NGILGLAYAALAKPSSSLETFFDSLVAQAKIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 150 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 151 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 205 Query: 524 IVFSQHYWN 550 + Q +N Sbjct: 206 LRLPQKVFN 214 [17][TOP] >UniRef100_UPI0000EB06B7 Beta-secretase 2 precursor (EC 3.4.23.45) (Beta-site APP-cleaving enzyme 2) (Aspartyl protease 1) (Asp 1) (ASP1) (Membrane-associated aspartic protease 1) (Memapsin-1) (Aspartic-like protease 56 kDa) (Down region aspartic protease). n=1 Tax=Canis lupus familiaris RepID=UPI0000EB06B7 Length = 423 Score = 60.8 bits (146), Expect = 6e-08 Identities = 49/129 (37%), Positives = 65/129 (50%), Gaps = 14/129 (10%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V KI N+FSM + G GG LVLGG Sbjct: 99 NGILGLAYAALAKPSSSLETFFDSLVAQAKIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 158 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 159 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 213 Query: 524 IVFSQHYWN 550 + Q +N Sbjct: 214 LRLPQKVFN 222 [18][TOP] >UniRef100_Q6PB20 MGC68482 protein n=1 Tax=Xenopus laevis RepID=Q6PB20_XENLA Length = 499 Score = 60.8 bits (146), Expect = 6e-08 Identities = 56/171 (32%), Positives = 82/171 (47%), Gaps = 14/171 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSC 256 G +G G+ V+ ++ G N TF + IL+ F GILGLA+ L+ S Sbjct: 135 GSWTGLLGKDVV-SMPKGVNGTFLINIASILQSDNFFLPNINWQGILGLAYSTLSKPSSS 193 Query: 257 VEPTFDAMVRHLKIDNIFSMCITGTG----------GKLVLGGHDTTLAKADPVWVPMVL 406 VEP FD++V+ I +IFSM + G G G LVLGG + +L K D + P+ Sbjct: 194 VEPFFDSLVQQRNIPDIFSMQMCGAGQPTPGNGINAGSLVLGGIEPSLYKGDIWYTPI-- 251 Query: 407 RSPPSYYPFKVTGPLRIGDRDAT---ELPPLRKGIVDSGTTLIVFSQHYWN 550 + YY +V +G ++ + K IVDSGTTL+ +N Sbjct: 252 -TEEWYYQVEVL-KFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFN 300 [19][TOP] >UniRef100_Q5XJ89 Zgc:103530 n=1 Tax=Danio rerio RepID=Q5XJ89_DANRE Length = 372 Score = 60.8 bits (146), Expect = 6e-08 Identities = 47/121 (38%), Positives = 64/121 (52%), Gaps = 15/121 (12%) Frame = +2 Query: 209 GILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG-----------TGGKLVLGG 355 GILGLA+P LA VEP F+++VR I ++FS+ + G GG L++GG Sbjct: 183 GILGLAYPLLARPDPSVEPFFNSVVRQTGIPDVFSLQMCGAGVPASTTGDPAGGSLIMGG 242 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + TL + P+W VL YY +V L +GD+ D E K IVDSGTTL Sbjct: 243 VEPTLHRG-PIWYTPVLEE--WYYQVEVL-KLEVGDQNLNLDCKEYNS-DKAIVDSGTTL 297 Query: 524 I 526 + Sbjct: 298 L 298 [20][TOP] >UniRef100_B4F734 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana) tropicalis RepID=B4F734_XENTR Length = 499 Score = 60.8 bits (146), Expect = 6e-08 Identities = 57/171 (33%), Positives = 81/171 (47%), Gaps = 14/171 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSC 256 G +G G+ VI ++ G N TF + I + F GILGLA+ LA S Sbjct: 135 GSWTGLLGKDVI-SMPKGVNGTFLINIASIFQSENFFLPNINWQGILGLAYSTLAKPSSS 193 Query: 257 VEPTFDAMVRHLKIDNIFSMCITGTG----------GKLVLGGHDTTLAKADPVWVPMVL 406 VEP FD++V+ I NIFSM + G G G LVLGG + +L + D + P+ Sbjct: 194 VEPFFDSLVQQENIPNIFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQGDIWYTPI-- 251 Query: 407 RSPPSYYPFKVTGPLRIGDRDAT---ELPPLRKGIVDSGTTLIVFSQHYWN 550 + YY +V +G ++ + K IVDSGTTL+ +N Sbjct: 252 -TEEWYYQVEVL-KFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFN 300 [21][TOP] >UniRef100_B7SCP9 Pepsinogen A1 n=2 Tax=Epinephelus coioides RepID=B7SCP9_EPICO Length = 376 Score = 60.1 bits (144), Expect = 1e-07 Identities = 51/157 (32%), Positives = 78/157 (49%), Gaps = 4/157 (2%) Frame = +2 Query: 71 LSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTVDGILGLAWPKLACNP 250 + +G GS +G L IDN+ G VFG ++P T DGILGLA+ +A + Sbjct: 128 IQYGTGS-MTGHLAIDNVEVGGITVQNQVFGISRTEAPFMAHMTADGILGLAFQTIAADN 186 Query: 251 SCVEPTFDAMVRH-LKIDNIFSMCITG---TGGKLVLGGHDTTLAKADPVWVPMVLRSPP 418 V P FD MV+ L +FS+ ++ G ++V GG D++ WVP+ + Sbjct: 187 --VVPVFDNMVKQGLVSQPLFSVYLSSHGEQGSEVVFGGIDSSHYTGQVTWVPL---TSA 241 Query: 419 SYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 +Y+ K+ G G A + I+D+GT+LIV Sbjct: 242 TYWQIKMDGVKINGQTVA--CAGGCQAIIDTGTSLIV 276 [22][TOP] >UniRef100_B8YJG7 Rhizopuspepsin-like protein n=1 Tax=Rhizopus oryzae RepID=B8YJG7_RHIOR Length = 390 Score = 59.7 bits (143), Expect = 1e-07 Identities = 53/182 (29%), Positives = 83/182 (45%), Gaps = 7/182 (3%) Frame = +2 Query: 5 CGKCSATKACCSKLNT---DNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILK 175 CG + TK SK +T D + +S+GDGS ASG L DN+ G + + Sbjct: 117 CGG-TQTKYNPSKSSTYAPDGRAWSISYGDGSTASGVLATDNVNLGGLLIKKQTIELAKR 175 Query: 176 DSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGGKL 343 +S F R DG+LGL + + P + + + L IF + + G GG+ Sbjct: 176 ESSSFSRGPNDGLLGLGFNTITTVRGIKTPMDNLISQGLISKPIFGVYLGKQKNGGGGEY 235 Query: 344 VLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTL 523 + GG+D++ K V VP + + +Y V G R + GI+D+GTTL Sbjct: 236 IFGGYDSSKFKGSLVTVP--VDNSNGWYSITVKQATVGGSRVSGSF----DGILDTGTTL 289 Query: 524 IV 529 ++ Sbjct: 290 LI 291 [23][TOP] >UniRef100_B3MSE3 GF20814 n=1 Tax=Drosophila ananassae RepID=B3MSE3_DROAN Length = 405 Score = 59.3 bits (142), Expect = 2e-07 Identities = 53/166 (31%), Positives = 87/166 (52%), Gaps = 8/166 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F++++G GS SG + D ++ + FG + +S +F ++ DGILGLA+P LA Sbjct: 133 FNITYGTGS-VSGFMSQDVVSVAGLVIRNQTFGEVTSESGSNFLNASFDGILGLAFPMLA 191 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSMCI--TGT----GGKLVLGGHDTTLAKADPVWVPM 400 N V P F ++ + +FS + GT GG+L+LGG D L + +VP+ Sbjct: 192 VN--LVTPFFQNLISQKVVQQPVFSFYLRNNGTTVTYGGELILGGSDPKLYRGKLTYVPV 249 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQ 538 S P+Y+ F T +++G+ T + I D+GT+L+V Q Sbjct: 250 ---SYPAYWQF-YTDSIQMGN---TLISTGDAAIADTGTSLLVAPQ 288 [24][TOP] >UniRef100_UPI000155C55A PREDICTED: similar to CDA13 n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155C55A Length = 553 Score = 58.5 bits (140), Expect = 3e-07 Identities = 46/125 (36%), Positives = 64/125 (51%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V+ KI NIFSM + G GG LV+GG Sbjct: 229 NGILGLAYAALAKPSSSLETFFDSLVKQAKIPNIFSMQMCGAGLPVAGTGINGGSLVMGG 288 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 +++L D + P+ YY ++ L +G + D E K IVDSGTTL Sbjct: 289 IESSLYTGDIWYTPI---KEEWYYQIEIL-KLEVGGQNLNLDCREY-NANKAIVDSGTTL 343 Query: 524 IVFSQ 538 + Q Sbjct: 344 LRLPQ 348 [25][TOP] >UniRef100_B3MJW5 GF19728 n=1 Tax=Drosophila ananassae RepID=B3MJW5_DROAN Length = 390 Score = 58.5 bits (140), Expect = 3e-07 Identities = 57/191 (29%), Positives = 86/191 (45%), Gaps = 18/191 (9%) Frame = +2 Query: 11 KCSATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNL-TWGNNITFPV 154 KCSA+ C K N + G F + +G GS SG L D + G I Sbjct: 105 KCSASNKACQKHNKYHSGESSTYVANGESFSIEYGTGS-LSGFLSTDTVEVAGIQIKSQT 163 Query: 155 VFGGILKDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDN---IFSMCIT 325 + F + GILGLA+ +A + V P +D M+ +D F + + Sbjct: 164 FAEATNEPGSTFTDAKFAGILGLAFKSIAVDG--VTPPWDNMIEQKLLDEPVISFYLKLK 221 Query: 326 GT---GGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRK 496 GT GG+++LGG D++L K WVP+ + +Y+ FK+T G + + Sbjct: 222 GTAVQGGEMILGGIDSSLYKGSLTWVPV---TKAAYWQFKLTAIKTKG----VFISRNTQ 274 Query: 497 GIVDSGTTLIV 529 I D+GT+LIV Sbjct: 275 AIADTGTSLIV 285 [26][TOP] >UniRef100_Q7T0Y2 Bace2-prov protein n=1 Tax=Xenopus laevis RepID=Q7T0Y2_XENLA Length = 500 Score = 58.2 bits (139), Expect = 4e-07 Identities = 57/172 (33%), Positives = 83/172 (48%), Gaps = 15/172 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSC 256 G +G G+ V+ ++ G N TF + I + F GILGLA+ LA S Sbjct: 136 GSWTGLLGKDVV-SIPKGVNGTFLINIASIFQSESFFLPNINWQGILGLAYSTLAKPSSS 194 Query: 257 VEPTFDAMVRHLKIDNIFSMCITGTG----------GKLVLGGHDTTLAKADPVWVPMVL 406 VEP FD++V+ I ++FSM + G G G LVLGG + +L K + + P+ Sbjct: 195 VEPFFDSLVQQENIPDVFSMQMCGAGQSSPGNGINAGSLVLGGVEPSLYKGNIWYTPI-- 252 Query: 407 RSPPSYYPFKV----TGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQHYWN 550 + YY +V G R+ + D T + K IVDSGTTL+ +N Sbjct: 253 -TEEWYYQVEVLKFEVGGQRL-NLDCT-VYNSDKAIVDSGTTLLRLPDKVFN 301 [27][TOP] >UniRef100_O93458 Cathepsin D n=1 Tax=Podarcis siculus RepID=O93458_PODSI Length = 399 Score = 57.8 bits (138), Expect = 5e-07 Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 7/161 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSP-DFERSTVDGILGLAWPKLA 241 F + +G GS SG L D++T G+ I +FG +K F + DGILGLA+PK++ Sbjct: 135 FAIHYGTGS-LSGFLSQDHVTIGDLIVQNQLFGEAVKQPGITFIAAKFDGILGLAYPKIS 193 Query: 242 CNPSCVEPTFD-AMVRHLKIDNIFSMCIT-----GTGGKLVLGGHDTTLAKADPVWVPMV 403 + V P FD AM + L N+FS + TGG+L+ GG D D WV + Sbjct: 194 VDK--VLPFFDNAMKQALMEKNLFSFYLNRDPKGATGGELLFGGVDPQYYTGDFTWVNVT 251 Query: 404 LRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 ++ + KV D T + IVD+GT+LI Sbjct: 252 RKAYWQIHMEKVD-----VDNGLTVCKDGCEAIVDTGTSLI 287 [28][TOP] >UniRef100_Q9W5G3 Pepsinogen-like n=1 Tax=Drosophila melanogaster RepID=Q9W5G3_DROME Length = 407 Score = 57.8 bits (138), Expect = 5e-07 Identities = 49/166 (29%), Positives = 85/166 (51%), Gaps = 8/166 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F +++G GS SG L +D + + FG + + +F + DGILG+ +P LA Sbjct: 134 FSITYGTGS-VSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSLA 192 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSM------CITGTGGKLVLGGHDTTLAKADPVWVPM 400 + V PTF M++ + + +FS +T GG+L+LGG D +L +V + Sbjct: 193 VDG--VTPTFQNMMQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNV 250 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQ 538 V +Y+ F+ T +++G +T + + I D+GT+LI+ Q Sbjct: 251 V---QAAYWKFQ-TDYIKVG---STSISTFAQAIADTGTSLIIAPQ 289 [29][TOP] >UniRef100_Q5BIE7 RE41891p (Fragment) n=1 Tax=Drosophila melanogaster RepID=Q5BIE7_DROME Length = 418 Score = 57.8 bits (138), Expect = 5e-07 Identities = 49/166 (29%), Positives = 85/166 (51%), Gaps = 8/166 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F +++G GS SG L +D + + FG + + +F + DGILG+ +P LA Sbjct: 145 FSITYGTGS-VSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSLA 203 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSM------CITGTGGKLVLGGHDTTLAKADPVWVPM 400 + V PTF M++ + + +FS +T GG+L+LGG D +L +V + Sbjct: 204 VDG--VTPTFQNMMQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNV 261 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQ 538 V +Y+ F+ T +++G +T + + I D+GT+LI+ Q Sbjct: 262 V---QAAYWKFQ-TDYIKVG---STSISTFAQAIADTGTSLIIAPQ 300 [30][TOP] >UniRef100_O76921 EG:EG0001.1 protein (Fbgn0011822;pcl protein) n=1 Tax=Drosophila melanogaster RepID=O76921_DROME Length = 407 Score = 57.8 bits (138), Expect = 5e-07 Identities = 49/166 (29%), Positives = 85/166 (51%), Gaps = 8/166 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F +++G GS SG L +D + + FG + + +F + DGILG+ +P LA Sbjct: 134 FSITYGTGS-VSGYLSVDCVGFAGLTIQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSLA 192 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSM------CITGTGGKLVLGGHDTTLAKADPVWVPM 400 + V PTF M++ + + +FS +T GG+L+LGG D +L +V + Sbjct: 193 VDG--VTPTFQNMMQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNV 250 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQ 538 V +Y+ F+ T +++G +T + + I D+GT+LI+ Q Sbjct: 251 V---QAAYWKFQ-TDYIKVG---STSISTFAQAIADTGTSLIIAPQ 289 [31][TOP] >UniRef100_B4N9T8 GK11645 n=1 Tax=Drosophila willistoni RepID=B4N9T8_DROWI Length = 388 Score = 57.8 bits (138), Expect = 5e-07 Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 7/162 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPD-FERSTVDGILGLAWPKLA 241 F +++G GS SG L D +T G + FG + D F + GI+GLA+ K+A Sbjct: 133 FAIAYGTGS-LSGRLAEDTVTIGQMVVRNQTFGVAEHEPGDTFIDTNFAGIVGLAFRKIA 191 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSMCITG-----TGGKLVLGGHDTTLAKADPVWVPMV 403 V P F +M +D +FS + +GG+L+ GG D+T +VP+ Sbjct: 192 --EQHVTPLFQSMCDQKLVDQCVFSFYLKRNGSERSGGELLFGGTDSTKFTGQLTYVPL- 248 Query: 404 LRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 S P Y+ F++ G G R A R+ I D+GT+L+V Sbjct: 249 --SNPGYWQFEMQGIEIDGQRIAEH----RQAIADTGTSLLV 284 [32][TOP] >UniRef100_UPI0000E7FA91 PREDICTED: similar to beta-site APP cleaving enzyme 2 n=1 Tax=Gallus gallus RepID=UPI0000E7FA91 Length = 500 Score = 57.4 bits (137), Expect = 7e-07 Identities = 47/124 (37%), Positives = 63/124 (50%), Gaps = 14/124 (11%) Frame = +2 Query: 209 GILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGH 358 GILGLA+ LA S VE FD++V+ KI NIFS+ + G GG LVLGG Sbjct: 177 GILGLAYDTLAKPSSSVETFFDSLVKQAKIPNIFSLQMCGAGLPVSGSGTNGGSLVLGGI 236 Query: 359 DTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIG----DRDATELPPLRKGIVDSGTTLI 526 + +L K + + P+ YY ++ L +G + D E K IVDSGTTL+ Sbjct: 237 EPSLYKGNIWYTPI---KEEWYYQVEIL-KLEVGGQNLELDCREY-NADKAIVDSGTTLL 291 Query: 527 VFSQ 538 Q Sbjct: 292 RLPQ 295 [33][TOP] >UniRef100_UPI0001A2C8D7 cathepsin D n=1 Tax=Danio rerio RepID=UPI0001A2C8D7 Length = 397 Score = 57.4 bits (137), Expect = 7e-07 Identities = 62/193 (32%), Positives = 90/193 (46%), Gaps = 22/193 (11%) Frame = +2 Query: 14 CSATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNLTWGNNITFPVVF 160 CS T C + N G F + +G GS SG L D T G+ +F Sbjct: 106 CSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGSGS-LSGYLSQDTCTIGDIAVEKQIF 164 Query: 161 GGILKD-SPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKID-NIFSMCI---- 322 G +K F + DGILG+A+P++A + V P FD M+ K++ N+FS + Sbjct: 165 GEAIKQPGVAFIAAKFDGILGMAYPRIAVDG--VPPVFDMMMSQKKVEKNVFSFYLNRNP 222 Query: 323 -TGTGGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG 499 T GG+L+LGG D D +V + S +Y+ + G + IG + L KG Sbjct: 223 DTQPGGELLLGGTDPKYYTGDFNYVDI---SRQAYWQIHMDG-MSIGSGLS-----LCKG 273 Query: 500 ----IVDSGTTLI 526 IVD+GT+LI Sbjct: 274 GCEAIVDTGTSLI 286 [34][TOP] >UniRef100_UPI00017B4955 UPI00017B4955 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B4955 Length = 467 Score = 57.4 bits (137), Expect = 7e-07 Identities = 57/170 (33%), Positives = 78/170 (45%), Gaps = 28/170 (16%) Frame = +2 Query: 101 GELVID--NLTWGNNITFPVVFGGILKDS----PDFERSTVDGILGLAWPKLACNPSCVE 262 GEL +D ++ G N T P+ IL PD GILGLA+P LA S V Sbjct: 129 GELGVDLVSMPTGPNGTVPINIAAILSSDGFFLPDIHWQ---GILGLAYPLLARPDSSVT 185 Query: 263 PTFDAMVRHLKIDNIFSM------------------CITGTGGKLVLGGHDTTLAKADPV 388 P FD++VR L I ++FS+ C+ ++GG + TL + PV Sbjct: 186 PFFDSLVRQLGIPDVFSLQRLAAWMSCDPQMDWICVCVCSQ----IMGGTEPTLHRG-PV 240 Query: 389 WVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLI 526 W ++ YY +V L +GD+ D E K IVDSGTTL+ Sbjct: 241 WYTPIVEE--WYYQVEVL-KLEVGDQNLDLDCREY-NTDKAIVDSGTTLL 286 [35][TOP] >UniRef100_UPI00001612A9 beta-site APP-cleaving enzyme 2 isoform B preproprotein n=1 Tax=Homo sapiens RepID=UPI00001612A9 Length = 396 Score = 57.4 bits (137), Expect = 7e-07 Identities = 57/168 (33%), Positives = 78/168 (46%), Gaps = 15/168 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTV-DGILGLAWPKLACNPSC 256 G +G GE ++ + G N +F V I + F +GILGLA+ LA S Sbjct: 152 GSWTGFVGEDLV-TIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSS 210 Query: 257 VEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGHDTTLAKADPVWVPMVL 406 +E FD++V I N+FSM + G GG LVLGG + +L K D + P+ Sbjct: 211 LETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPI-- 268 Query: 407 RSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQ 538 YY ++ L IG + D E K IVDSGTTL+ Q Sbjct: 269 -KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTLLRLPQ 313 [36][TOP] >UniRef100_UPI000060E4EE Beta-site APP cleaving enzyme 2 n=2 Tax=Gallus gallus RepID=UPI000060E4EE Length = 416 Score = 57.4 bits (137), Expect = 7e-07 Identities = 47/124 (37%), Positives = 63/124 (50%), Gaps = 14/124 (11%) Frame = +2 Query: 209 GILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGH 358 GILGLA+ LA S VE FD++V+ KI NIFS+ + G GG LVLGG Sbjct: 93 GILGLAYDTLAKPSSSVETFFDSLVKQAKIPNIFSLQMCGAGLPVSGSGTNGGSLVLGGI 152 Query: 359 DTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIG----DRDATELPPLRKGIVDSGTTLI 526 + +L K + + P+ YY ++ L +G + D E K IVDSGTTL+ Sbjct: 153 EPSLYKGNIWYTPI---KEEWYYQVEIL-KLEVGGQNLELDCREY-NADKAIVDSGTTLL 207 Query: 527 VFSQ 538 Q Sbjct: 208 RLPQ 211 [37][TOP] >UniRef100_Q8JH28 Cathepsin D n=1 Tax=Danio rerio RepID=Q8JH28_DANRE Length = 398 Score = 57.4 bits (137), Expect = 7e-07 Identities = 62/193 (32%), Positives = 90/193 (46%), Gaps = 22/193 (11%) Frame = +2 Query: 14 CSATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNLTWGNNITFPVVF 160 CS T C + N G F + +G GS SG L D T G+ +F Sbjct: 107 CSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGSGS-LSGYLSQDTCTIGDIAVEKQIF 165 Query: 161 GGILKD-SPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKID-NIFSMCI---- 322 G +K F + DGILG+A+P++A + V P FD M+ K++ N+FS + Sbjct: 166 GEAIKQPGVAFIAAKFDGILGMAYPRIAVDG--VPPVFDMMMSQKKVEKNVFSFYLNRNP 223 Query: 323 -TGTGGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG 499 T GG+L+LGG D D +V + S +Y+ + G + IG + L KG Sbjct: 224 DTQPGGELLLGGTDPKYYTGDFNYVDI---SRQAYWQIHMDG-MSIGSGLS-----LCKG 274 Query: 500 ----IVDSGTTLI 526 IVD+GT+LI Sbjct: 275 GCEAIVDTGTSLI 287 [38][TOP] >UniRef100_Q8AWD9 Ctsd protein n=1 Tax=Danio rerio RepID=Q8AWD9_DANRE Length = 398 Score = 57.4 bits (137), Expect = 7e-07 Identities = 62/193 (32%), Positives = 90/193 (46%), Gaps = 22/193 (11%) Frame = +2 Query: 14 CSATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNLTWGNNITFPVVF 160 CS T C + N G F + +G GS SG L D T G+ +F Sbjct: 107 CSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGSGS-LSGYLSQDTCTIGDIAVEKQIF 165 Query: 161 GGILKD-SPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKID-NIFSMCI---- 322 G +K F + DGILG+A+P++A + V P FD M+ K++ N+FS + Sbjct: 166 GEAIKQPGVAFIAAKFDGILGMAYPRIAVDG--VPPVFDMMMSQKKVEKNVFSFYLNRNP 223 Query: 323 -TGTGGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG 499 T GG+L+LGG D D +V + S +Y+ + G + IG + L KG Sbjct: 224 DTQPGGELLLGGTDPKYYTGDFNYVDI---SRQAYWQIHMDG-MSIGSGLS-----LCKG 274 Query: 500 ----IVDSGTTLI 526 IVD+GT+LI Sbjct: 275 GCEAIVDTGTSLI 287 [39][TOP] >UniRef100_Q5QHS0 Beta-site APP cleaving enzyme 2 (Fragment) n=1 Tax=Gallus gallus RepID=Q5QHS0_CHICK Length = 392 Score = 57.4 bits (137), Expect = 7e-07 Identities = 47/124 (37%), Positives = 63/124 (50%), Gaps = 14/124 (11%) Frame = +2 Query: 209 GILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGH 358 GILGLA+ LA S VE FD++V+ KI NIFS+ + G GG LVLGG Sbjct: 69 GILGLAYDTLAKPSSSVETFFDSLVKQAKIPNIFSLQMCGAGLPVSGSGTNGGSLVLGGI 128 Query: 359 DTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIG----DRDATELPPLRKGIVDSGTTLI 526 + +L K + + P+ YY ++ L +G + D E K IVDSGTTL+ Sbjct: 129 EPSLYKGNIWYTPI---KEEWYYQVEIL-KLEVGGQNLELDCREY-NADKAIVDSGTTLL 183 Query: 527 VFSQ 538 Q Sbjct: 184 RLPQ 187 [40][TOP] >UniRef100_O00083 Extracellular aspartic proteinase n=1 Tax=Rhizopus microsporus RepID=O00083_9FUNG Length = 388 Score = 57.4 bits (137), Expect = 7e-07 Identities = 52/184 (28%), Positives = 84/184 (45%), Gaps = 9/184 (4%) Frame = +2 Query: 5 CGKCSA--TKACCSKLNT---DNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGI 169 C CS TK +K +T D + +S+GDGS ASG L D + G G Sbjct: 112 CSTCSNSHTKYNPNKSSTYKADGRPWSISYGDGSSASGILAKDTVNLGGLAIKDQTIGLA 171 Query: 170 LKDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGG 337 ++S F +DG+LGLA+ + P + + + L IF + + G GG Sbjct: 172 KRESSAFAEDVIDGLLGLAFNSITTVRGVKTPMDNLISQGLISRPIFGVYLGKASNGGGG 231 Query: 338 KLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGT 517 + + GG+D+T K VP + + ++ V G +IG + + I+D+GT Sbjct: 232 EYIFGGYDSTKFKGSFTTVP--IDNSEGFWGVTVKG-TKIGSK---SIGGSFSAILDTGT 285 Query: 518 TLIV 529 TL++ Sbjct: 286 TLLL 289 [41][TOP] >UniRef100_Q6IE75 Beta-secretase 2 n=1 Tax=Rattus norvegicus RepID=BACE2_RAT Length = 514 Score = 57.4 bits (137), Expect = 7e-07 Identities = 48/125 (38%), Positives = 63/125 (50%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V KI +IFSM + G GG LVLGG Sbjct: 190 NGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGG 249 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 250 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 304 Query: 524 IVFSQ 538 + Q Sbjct: 305 LRLPQ 309 [42][TOP] >UniRef100_Q9JL18 Beta-secretase 2 n=1 Tax=Mus musculus RepID=BACE2_MOUSE Length = 514 Score = 57.4 bits (137), Expect = 7e-07 Identities = 48/125 (38%), Positives = 63/125 (50%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V KI +IFSM + G GG LVLGG Sbjct: 190 NGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGG 249 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 250 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQNLNLDCREY-NADKAIVDSGTTL 304 Query: 524 IVFSQ 538 + Q Sbjct: 305 LRLPQ 309 [43][TOP] >UniRef100_Q9Y5Z0-2 Isoform 2 of Beta-secretase 2 n=1 Tax=Homo sapiens RepID=Q9Y5Z0-2 Length = 468 Score = 57.4 bits (137), Expect = 7e-07 Identities = 57/168 (33%), Positives = 78/168 (46%), Gaps = 15/168 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTV-DGILGLAWPKLACNPSC 256 G +G GE ++ + G N +F V I + F +GILGLA+ LA S Sbjct: 152 GSWTGFVGEDLV-TIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSS 210 Query: 257 VEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGHDTTLAKADPVWVPMVL 406 +E FD++V I N+FSM + G GG LVLGG + +L K D + P+ Sbjct: 211 LETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPI-- 268 Query: 407 RSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQ 538 YY ++ L IG + D E K IVDSGTTL+ Q Sbjct: 269 -KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTLLRLPQ 313 [44][TOP] >UniRef100_Q9Y5Z0-3 Isoform 3 of Beta-secretase 2 n=1 Tax=Homo sapiens RepID=Q9Y5Z0-3 Length = 396 Score = 57.4 bits (137), Expect = 7e-07 Identities = 57/168 (33%), Positives = 78/168 (46%), Gaps = 15/168 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTV-DGILGLAWPKLACNPSC 256 G +G GE ++ + G N +F V I + F +GILGLA+ LA S Sbjct: 152 GSWTGFVGEDLV-TIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSS 210 Query: 257 VEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGHDTTLAKADPVWVPMVL 406 +E FD++V I N+FSM + G GG LVLGG + +L K D + P+ Sbjct: 211 LETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPI-- 268 Query: 407 RSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQ 538 YY ++ L IG + D E K IVDSGTTL+ Q Sbjct: 269 -KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTLLRLPQ 313 [45][TOP] >UniRef100_Q9Y5Z0 Beta-secretase 2 n=3 Tax=Homo sapiens RepID=BACE2_HUMAN Length = 518 Score = 57.4 bits (137), Expect = 7e-07 Identities = 57/168 (33%), Positives = 78/168 (46%), Gaps = 15/168 (8%) Frame = +2 Query: 80 GDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTV-DGILGLAWPKLACNPSC 256 G +G GE ++ + G N +F V I + F +GILGLA+ LA S Sbjct: 152 GSWTGFVGEDLV-TIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSS 210 Query: 257 VEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGHDTTLAKADPVWVPMVL 406 +E FD++V I N+FSM + G GG LVLGG + +L K D + P+ Sbjct: 211 LETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPI-- 268 Query: 407 RSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLIVFSQ 538 YY ++ L IG + D E K IVDSGTTL+ Q Sbjct: 269 -KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTLLRLPQ 313 [46][TOP] >UniRef100_UPI000194DD88 PREDICTED: beta-site APP-cleaving enzyme 1 n=1 Tax=Taeniopygia guttata RepID=UPI000194DD88 Length = 531 Score = 57.0 bits (136), Expect = 9e-07 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 19/159 (11%) Frame = +2 Query: 101 GELVIDNLT--WGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSCVEPTF 271 GEL D +T G N+T I + F S +GILGLA+ ++A +EP F Sbjct: 169 GELGTDLVTIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFF 228 Query: 272 DAMVRHLKIDNIFSMCITGT-------------GGKLVLGGHDTTLAKADPVWVPMVLRS 412 D++V+ ++ NIFS+ + GT GG +++GG D +L D +W + + Sbjct: 229 DSLVKQTRVPNIFSLQLCGTGFSPNETEAVASVGGSMIIGGIDRSLYVGD-IWYTPIRK- 286 Query: 413 PPSYYPFKVTGPLRIGDRDAT---ELPPLRKGIVDSGTT 520 +Y + L + +D + K IVDSGTT Sbjct: 287 --EWYYEVIIVKLEVNGQDLNMDCKEYNYDKSIVDSGTT 323 [47][TOP] >UniRef100_UPI000194B743 PREDICTED: beta-site APP-cleaving enzyme 2 n=1 Tax=Taeniopygia guttata RepID=UPI000194B743 Length = 441 Score = 57.0 bits (136), Expect = 9e-07 Identities = 46/120 (38%), Positives = 61/120 (50%), Gaps = 14/120 (11%) Frame = +2 Query: 209 GILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGGH 358 GILGLA+ LA S VE FD++V+ KI NIFS+ + G GG LVLGG Sbjct: 168 GILGLAYDALAKPSSSVETFFDSLVKQAKIPNIFSLQMCGAGLPVSGSGTNGGSLVLGGI 227 Query: 359 DTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTLI 526 + +L D + P+ YY ++ L +G + D E K IVDSGTTL+ Sbjct: 228 EPSLYSGDIWYTPI---KEEWYYQVEIL-KLEVGGQNLQLDCREY-NADKAIVDSGTTLL 282 [48][TOP] >UniRef100_UPI0000E258A2 PREDICTED: beta-site APP-cleaving enzyme 2 isoform 3 n=1 Tax=Pan troglodytes RepID=UPI0000E258A2 Length = 392 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 68 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 127 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 128 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 182 Query: 524 IVFSQ 538 + Q Sbjct: 183 LRLPQ 187 [49][TOP] >UniRef100_UPI0000E258A0 PREDICTED: beta-site APP-cleaving enzyme 2 isoform 1 n=1 Tax=Pan troglodytes RepID=UPI0000E258A0 Length = 396 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 194 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 253 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 254 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 308 Query: 524 IVFSQ 538 + Q Sbjct: 309 LRLPQ 313 [50][TOP] >UniRef100_UPI0000E2589F PREDICTED: beta-site APP-cleaving enzyme 2 isoform 2 n=1 Tax=Pan troglodytes RepID=UPI0000E2589F Length = 468 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 194 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 253 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 254 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 308 Query: 524 IVFSQ 538 + Q Sbjct: 309 LRLPQ 313 [51][TOP] >UniRef100_UPI0000E2589E PREDICTED: beta-site APP-cleaving enzyme 2 isoform 5 n=2 Tax=Pan troglodytes RepID=UPI0000E2589E Length = 518 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 194 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 253 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 254 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 308 Query: 524 IVFSQ 538 + Q Sbjct: 309 LRLPQ 313 [52][TOP] >UniRef100_UPI0000D9A5BE PREDICTED: similar to beta-site APP-cleaving enzyme 2 isoform C preproprotein isoform 1 n=1 Tax=Macaca mulatta RepID=UPI0000D9A5BE Length = 388 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 194 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 253 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 254 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 308 Query: 524 IVFSQ 538 + Q Sbjct: 309 LRLPQ 313 [53][TOP] >UniRef100_UPI0000D9A5BD PREDICTED: similar to beta-site APP-cleaving enzyme 2 isoform A preproprotein isoform 2 n=1 Tax=Macaca mulatta RepID=UPI0000D9A5BD Length = 438 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 194 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 253 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 254 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 308 Query: 524 IVFSQ 538 + Q Sbjct: 309 LRLPQ 313 [54][TOP] >UniRef100_C3ZMY0 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3ZMY0_BRAFL Length = 493 Score = 57.0 bits (136), Expect = 9e-07 Identities = 53/149 (35%), Positives = 71/149 (47%), Gaps = 15/149 (10%) Frame = +2 Query: 119 NLTWGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLK 295 +L G N+T I S F S +GILGLA+ ++A S VEP FD+MV+ + Sbjct: 145 SLPSGPNVTVRANIASITSSSNFFINGSHWEGILGLAYSEIARPDSTVEPFFDSMVKEGR 204 Query: 296 IDNIFSMCITGT-----------GGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVT 442 + NIFSM + GT GG +V+GG D L + P+ + R YY +T Sbjct: 205 VSNIFSMQLCGTIDQGNTTDISVGGTMVVGGIDADLYEG-PILYSSLRRE--WYYEVVIT 261 Query: 443 GPLRIGD---RDATELPPLRKGIVDSGTT 520 G+ D E K IVDSGTT Sbjct: 262 KVEVDGEDLGMDCKEY-NFDKTIVDSGTT 289 [55][TOP] >UniRef100_B9X0K9 Aspartic proteinase n=1 Tax=Sitophilus zeamais RepID=B9X0K9_SITZE Length = 389 Score = 57.0 bits (136), Expect = 9e-07 Identities = 57/183 (31%), Positives = 93/183 (50%), Gaps = 11/183 (6%) Frame = +2 Query: 11 KCSATKACCSKLNTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSP-D 187 K ATK+ K N F +++G GS SG L D+L+ G+ FG +K+ Sbjct: 111 KYDATKSSTYKENGTE--FAITYGSGS-LSGYLSTDSLSVGSVQVKDQTFGEAIKEPGLT 167 Query: 188 FERSTVDGILGLAWPKLACNPSCVEPTFDAMV-RHLKIDNIFSMCITG-----TGGKLVL 349 F + DGILG+A+P+++ + V P F M+ ++L IFS + TGG+++L Sbjct: 168 FIAAKFDGILGMAYPRISVDG--VTPVFYNMIDQNLVAAPIFSFYLNRDPNAQTGGEIIL 225 Query: 350 GGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG----IVDSGT 517 GG D + D ++P+ +Y+ FK+ +++ D+ L KG I D+GT Sbjct: 226 GGSDPNYYEGDFTYLPV---DRQAYWQFKMDS-VQVADQS------LCKGGCEAIADTGT 275 Query: 518 TLI 526 +LI Sbjct: 276 SLI 278 [56][TOP] >UniRef100_B3P961 GG12763 n=1 Tax=Drosophila erecta RepID=B3P961_DROER Length = 407 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/166 (28%), Positives = 83/166 (50%), Gaps = 8/166 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F +++G GS SG L +DN+ + FG + + +F + DGILG+ +P LA Sbjct: 134 FSITYGTGS-VSGYLSVDNVGFAGLTVQKQTFGEVTTEQGTNFVDAYFDGILGMGFPSLA 192 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSMCITGTG------GKLVLGGHDTTLAKADPVWVPM 400 + V PTF M+ + + +FS + G G+L+LGG D +L +V + Sbjct: 193 VDG--VTPTFQNMISQGLVQSPVFSFFLRDNGSVIFYGGELILGGSDPSLYSGSLTYVDV 250 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQ 538 + +Y+ F+ T +++G + + + I D+GT+LI+ Q Sbjct: 251 I---QTAYWKFQ-TDYIKVG---SALISTFAEAIADTGTSLIIAPQ 289 [57][TOP] >UniRef100_B3KNE8 cDNA FLJ14470 fis, clone MAMMA1001008, highly similar to Beta-secretase 2 n=1 Tax=Homo sapiens RepID=B3KNE8_HUMAN Length = 355 Score = 57.0 bits (136), Expect = 9e-07 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 14/125 (11%) Frame = +2 Query: 206 DGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG----------TGGKLVLGG 355 +GILGLA+ LA S +E FD++V I N+FSM + G GG LVLGG Sbjct: 31 NGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGG 90 Query: 356 HDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDR----DATELPPLRKGIVDSGTTL 523 + +L K D + P+ YY ++ L IG + D E K IVDSGTTL Sbjct: 91 IEPSLYKGDIWYTPI---KEEWYYQIEIL-KLEIGGQSLNLDCREY-NADKAIVDSGTTL 145 Query: 524 IVFSQ 538 + Q Sbjct: 146 LRLPQ 150 [58][TOP] >UniRef100_B8YJG1 Rhizopuspepsin 6 n=1 Tax=Rhizopus oryzae RepID=B8YJG1_RHIOR Length = 392 Score = 57.0 bits (136), Expect = 9e-07 Identities = 52/183 (28%), Positives = 83/183 (45%), Gaps = 7/183 (3%) Frame = +2 Query: 2 SCGKCSATKACCSKLNT---DNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGIL 172 SCG S T SK +T D + + +GDGS +SG L D + G Sbjct: 116 SCGS-SQTLYDSSKSSTYEKDGRPWSIRYGDGSTSSGILAYDTVNLGGLTIKKQTIELAK 174 Query: 173 KDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGGK 340 +S F +DG+LGLA+ +A P + + + L IF + + G GG+ Sbjct: 175 TESDAFVSGAIDGLLGLAFDSIASVKGVKTPVDNLISQGLISKPIFGVHLGKASNGGGGE 234 Query: 341 LVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTT 520 + GG+D + K D V + + ++ V ++GD+ AT+ I+D+GTT Sbjct: 235 YIFGGYDASKIKGDLTTVK--IDNSQGFWGITVDN-TKVGDKSATD---SFSAILDTGTT 288 Query: 521 LIV 529 L+V Sbjct: 289 LLV 291 [59][TOP] >UniRef100_B8P604 Putative uncharacterized protein n=1 Tax=Postia placenta Mad-698-R RepID=B8P604_POSPM Length = 407 Score = 57.0 bits (136), Expect = 9e-07 Identities = 48/180 (26%), Positives = 79/180 (43%), Gaps = 5/180 (2%) Frame = +2 Query: 2 SCGKCSAT---KACCSKLNTDNCG-FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGI 169 SC C A+ KA S + G F + +GDGS ASG + D ++ + Sbjct: 130 SCSGCKASSSYKASSSSSSKKKSGTFQIEYGDGSEASGPIYADTVSVAAVKVTGQTLSAV 189 Query: 170 LKDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKI-DNIFSMCITGTGGKLV 346 +S D DG+LG+ +P A + +P F V + + +F+ + +G +L Sbjct: 190 TSESGDLVGDAADGLLGMGFP--AISSLNADPFFQTAVEQGAVSEGVFAFKLASSGSELY 247 Query: 347 LGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 LGG D++L + L S Y+ + G+ A+ + I+DSGTTL+ Sbjct: 248 LGGTDSSLYSGSIEY--HALSSSVGYWQIGGASAIVNGETAASGF----QTIIDSGTTLM 301 [60][TOP] >UniRef100_Q86KL6 Putative uncharacterized protein n=1 Tax=Dictyostelium discoideum RepID=Q86KL6_DICDI Length = 492 Score = 56.6 bits (135), Expect = 1e-06 Identities = 60/188 (31%), Positives = 92/188 (48%), Gaps = 6/188 (3%) Frame = +2 Query: 8 GKCSATKACCSKLNTDN-CGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSP 184 G SA+ +C N + C F + +GDGS G++ D +T + ++ + FG +++ Sbjct: 157 GSGSASPSCKLHQNAKSTCDFIILYGDGSKIKGKVFSDEIT-VSGVSSTIYFGANVEEVG 215 Query: 185 DFERSTVDGILGLAWPKLACNPSCVEPTFDAMVR-HLKIDNIFSMCITGTG-GKLVLGGH 358 FE DGI+GL + + N + V FD+MVR + I NIF + + G G L LG Sbjct: 216 AFEYPRADGIMGLG--RTSNNKNLVPTIFDSMVRSNSSIKNIFGIYLDYHGQGYLSLGKI 273 Query: 359 DTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG--IVDSGTT-LIV 529 + + P+ P +Y K T R+ D T P G IVDSGT+ LI+ Sbjct: 274 NHHYYIGSIQYTPIQPAGP--FYAIKPTS-FRV---DNTSFPANSMGQVIVDSGTSDLIL 327 Query: 530 FSQHYWNL 553 S+ Y +L Sbjct: 328 TSRVYDHL 335 [61][TOP] >UniRef100_B4MAU6 GJ15982 n=1 Tax=Drosophila virilis RepID=B4MAU6_DROVI Length = 374 Score = 56.6 bits (135), Expect = 1e-06 Identities = 48/169 (28%), Positives = 81/169 (47%), Gaps = 6/169 (3%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKD-SPDFERSTVDGILGLAWPKLA 241 F + +G GS SG L D + + F + F + DGILG+A+ LA Sbjct: 128 FSIQYGSGS-LSGFLSTDTVDVNGLVIKSQTFAEATSEPGTSFNNAKFDGILGMAYQSLA 186 Query: 242 CNPSCVEPTFDAMVRHLKIDNIFSMCIT--GT---GGKLVLGGHDTTLAKADPVWVPMVL 406 + + V P ++ + + L ++FS + GT GG+L+ GG D++L D +VP+ Sbjct: 187 VD-NVVPPFYNMVSQGLVDQSVFSFYLARDGTSSQGGELIFGGSDSSLYSGDLTYVPI-- 243 Query: 407 RSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQHYWNL 553 S Y+ F + G D L + I D+GT+L+V S+ +++ Sbjct: 244 -SEQGYWQFTMAG----ASIDGQSLCDNCQAIADTGTSLLVVSEAAYDI 287 [62][TOP] >UniRef100_Q1L9E4 Cathepsin D n=1 Tax=Danio rerio RepID=Q1L9E4_DANRE Length = 398 Score = 56.2 bits (134), Expect = 2e-06 Identities = 61/193 (31%), Positives = 90/193 (46%), Gaps = 22/193 (11%) Frame = +2 Query: 14 CSATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNLTWGNNITFPVVF 160 CS T C + N G F + +G GS SG L D T G+ +F Sbjct: 107 CSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGSGS-LSGYLSQDTCTIGDIAVEKQIF 165 Query: 161 GGILKD-SPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKID-NIFSMCI---- 322 G +K F + DGILG+A+P+++ + V P FD M+ K++ N+FS + Sbjct: 166 GEAIKQPGVAFIAAKFDGILGMAYPRISVDG--VPPVFDMMMSQKKVEKNVFSFYLNRNP 223 Query: 323 -TGTGGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG 499 T GG+L+LGG D D +V + S +Y+ + G + IG + L KG Sbjct: 224 DTQPGGELLLGGTDPKYYTGDFNYVDI---SRQAYWQIHMDG-MSIGSGLS-----LCKG 274 Query: 500 ----IVDSGTTLI 526 IVD+GT+LI Sbjct: 275 GCEAIVDTGTSLI 287 [63][TOP] >UniRef100_B4I916 GM19043 n=1 Tax=Drosophila sechellia RepID=B4I916_DROSE Length = 407 Score = 56.2 bits (134), Expect = 2e-06 Identities = 47/163 (28%), Positives = 84/163 (51%), Gaps = 8/163 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F +++G GS SG L D +++ FG + + +F + DGILG+ +P LA Sbjct: 134 FSITYGTGS-VSGYLSADYVSFAGLTVQNQTFGEVTTEQGTNFVDAYFDGILGMGFPSLA 192 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSM------CITGTGGKLVLGGHDTTLAKADPVWVPM 400 + V PTF M++ + + +FS +T GG+L+LGG D +L +V + Sbjct: 193 VDG--VTPTFQNMIQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNV 250 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 + +Y+ F+ T +++G +T + + I D+GT+LI+ Sbjct: 251 I---QAAYWKFQ-TDYIKVG---STFISTFAQAIADTGTSLII 286 [64][TOP] >UniRef100_Q3SCM8 Pepsinogen A (Fragment) n=1 Tax=Melanogrammus aeglefinus RepID=Q3SCM8_MELAE Length = 269 Score = 55.8 bits (133), Expect = 2e-06 Identities = 47/157 (29%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +2 Query: 71 LSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTVDGILGLAWPKLACNP 250 + +G GS +G L +D + G VFG ++P DGILGLA+ +A + Sbjct: 43 IQYGTGS-MTGHLAVDTVEVGGITVANQVFGISQTEAPFMSHMVADGILGLAFQSIASDN 101 Query: 251 SCVEPTFDAMV-RHLKIDNIFSMCIT---GTGGKLVLGGHDTTLAKADPVWVPMVLRSPP 418 V P FD MV ++L +FS+ ++ G +V GG D +L W+P+ + Sbjct: 102 --VVPVFDMMVEQNLVAQQMFSVYLSRGGQEGSVVVFGGVDESLMSGQITWIPL---TSA 156 Query: 419 SYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 +Y+ K+ G+ A + I+D+GT+LIV Sbjct: 157 TYWQIKMDSVTINGNPVACN--GGCQAIIDTGTSLIV 191 [65][TOP] >UniRef100_A1YZ22 Aspartic protease n=1 Tax=Musca domestica RepID=A1YZ22_MUSDO Length = 379 Score = 55.5 bits (132), Expect = 3e-06 Identities = 52/166 (31%), Positives = 81/166 (48%), Gaps = 6/166 (3%) Frame = +2 Query: 71 LSFGDGSGASGELVIDNLTW-GNNITFPVVFGGILKDSPDFERSTVDGILGLAWPKLACN 247 +S+G GS SG L D++T G I V + + F + DGI G+A+ LA Sbjct: 130 ISYGSGS-MSGFLSQDDVTVEGLTIKNQVFAEAMNEPGNSFTDANFDGIFGMAYQSLA-E 187 Query: 248 PSCVEPTFDAMVRHLKIDNIFSMCIT--GT---GGKLVLGGHDTTLAKADPVWVPMVLRS 412 + V P ++ + L N+FS + GT GG+++LGG D++L D +VP+ S Sbjct: 188 DNVVPPFYNMFAQGLVDANMFSFLLNRDGTSTDGGQMILGGVDSSLYTGDITYVPV---S 244 Query: 413 PPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIVFSQHYWN 550 Y+ F+VT G + + I D+GT+LIV +N Sbjct: 245 SQGYWQFEVTS----GAIKGQSICDNCQAIADTGTSLIVAPSDAYN 286 [66][TOP] >UniRef100_UPI000185FD11 hypothetical protein BRAFLDRAFT_202616 n=1 Tax=Branchiostoma floridae RepID=UPI000185FD11 Length = 439 Score = 55.1 bits (131), Expect = 3e-06 Identities = 53/149 (35%), Positives = 70/149 (46%), Gaps = 15/149 (10%) Frame = +2 Query: 119 NLTWGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLK 295 +L G N+T I S F S +GILGLA+ ++A S VEP FD+MV+ Sbjct: 83 SLPSGPNVTVRANIASITSSSNFFINGSHWEGILGLAYSEIARPDSTVEPFFDSMVKEGH 142 Query: 296 IDNIFSMCITGT-----------GGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVT 442 + NIFSM + GT GG +V+GG D L + P+ + R YY +T Sbjct: 143 VPNIFSMQLCGTIDQGNTTDISVGGTMVVGGIDADLYEG-PILYSSLRRE--WYYEVIIT 199 Query: 443 GPLRIGD---RDATELPPLRKGIVDSGTT 520 G+ D E K IVDSGTT Sbjct: 200 KVEVDGEDLGMDCKEY-NFDKTIVDSGTT 227 [67][TOP] >UniRef100_B6AJA9 Eukaryotic aspartyl protease family protein n=1 Tax=Cryptosporidium muris RN66 RepID=B6AJA9_9CRYT Length = 788 Score = 55.1 bits (131), Expect = 3e-06 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 13/119 (10%) Frame = +2 Query: 47 NTDNCGFHLSFGDGSGASGELVID-----NLTWGNNITFP------VVFGGILKDSPDFE 193 N + C + +++ +GS SG D N GN+++ P VFGGI +++ F Sbjct: 105 NGNQCAYDITYMEGSHLSGRYFEDFVSVRNENHGNSVSIPYAIGLSTVFGGITRETSLFY 164 Query: 194 RSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLK-IDN-IFSMCITGTGGKLVLGGHDT 364 GILGLA+ K+ +P F + R K I N I SMC + GG L GG+++ Sbjct: 165 SQAASGILGLAYSKITKGR---DPFFQSWSRRSKWIGNPILSMCFSTEGGMLAFGGYNS 220 [68][TOP] >UniRef100_UPI0000ECA24E Beta-site APP cleaving enzyme n=1 Tax=Gallus gallus RepID=UPI0000ECA24E Length = 304 Score = 54.7 bits (130), Expect = 5e-06 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 19/159 (11%) Frame = +2 Query: 101 GELVIDNLT--WGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSCVEPTF 271 GEL D +T G N+T I + F S +GILGLA+ ++A +EP F Sbjct: 64 GELGTDLVTIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFF 123 Query: 272 DAMVRHLKIDNIFSMCITG-------------TGGKLVLGGHDTTLAKADPVWVPMVLRS 412 D++V+ ++ NIFS+ + G GG +++GG D +L D +W + + Sbjct: 124 DSLVKQTQVPNIFSLQLCGAGFSPNETETLASVGGSMIIGGIDRSLYVGD-IWYTPIRK- 181 Query: 413 PPSYYPFKVTGPLRIGDRDAT---ELPPLRKGIVDSGTT 520 +Y + L + +D + K IVDSGTT Sbjct: 182 --EWYYEVIIVKLEVNGQDLNMDCKEYNYDKSIVDSGTT 218 [69][TOP] >UniRef100_UPI0000ECA24D Beta-site APP cleaving enzyme n=2 Tax=Gallus gallus RepID=UPI0000ECA24D Length = 426 Score = 54.7 bits (130), Expect = 5e-06 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 19/159 (11%) Frame = +2 Query: 101 GELVIDNLT--WGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSCVEPTF 271 GEL D +T G N+T I + F S +GILGLA+ ++A +EP F Sbjct: 64 GELGTDLVTIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFF 123 Query: 272 DAMVRHLKIDNIFSMCITG-------------TGGKLVLGGHDTTLAKADPVWVPMVLRS 412 D++V+ ++ NIFS+ + G GG +++GG D +L D +W + + Sbjct: 124 DSLVKQTQVPNIFSLQLCGAGFSPNETETLASVGGSMIIGGIDRSLYVGD-IWYTPIRK- 181 Query: 413 PPSYYPFKVTGPLRIGDRDAT---ELPPLRKGIVDSGTT 520 +Y + L + +D + K IVDSGTT Sbjct: 182 --EWYYEVIIVKLEVNGQDLNMDCKEYNYDKSIVDSGTT 218 [70][TOP] >UniRef100_Q5QHS1 Beta-site APP cleaving enzyme (Fragment) n=1 Tax=Gallus gallus RepID=Q5QHS1_CHICK Length = 334 Score = 54.7 bits (130), Expect = 5e-06 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 19/159 (11%) Frame = +2 Query: 101 GELVIDNLT--WGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLACNPSCVEPTF 271 GEL D +T G N+T I + F S +GILGLA+ ++A +EP F Sbjct: 64 GELGTDLVTIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFF 123 Query: 272 DAMVRHLKIDNIFSMCITG-------------TGGKLVLGGHDTTLAKADPVWVPMVLRS 412 D++V+ ++ NIFS+ + G GG +++GG D +L D +W + + Sbjct: 124 DSLVKQTQVPNIFSLQLCGAGFSPNETETLASVGGSMIIGGIDRSLYVGD-IWYTPIRK- 181 Query: 413 PPSYYPFKVTGPLRIGDRDAT---ELPPLRKGIVDSGTT 520 +Y + L + +D + K IVDSGTT Sbjct: 182 --EWYYEVIIVKLEVNGQDLNMDCKEYNYDKSIVDSGTT 218 [71][TOP] >UniRef100_C1E8U4 Predicted protein n=1 Tax=Micromonas sp. RCC299 RepID=C1E8U4_9CHLO Length = 649 Score = 54.7 bits (130), Expect = 5e-06 Identities = 49/168 (29%), Positives = 74/168 (44%), Gaps = 12/168 (7%) Frame = +2 Query: 53 DNCGFHLSFGDGSGASGELVIDNLTWGNNI------TFPVVFGGILKDSPDFERSTVDGI 214 + C + ++ +GSG SG+LV D + +G +I T VVFG +S DG+ Sbjct: 188 NRCTYSRTYAEGSGVSGDLVRDKMHFGGDIAPATNGTLDVVFGCTNAESGTIHDQEADGL 247 Query: 215 LGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITG--TGGKLVLGGHDTTLAKADPV 388 +GL + A P+ + T + +FS+C GG L G T V Sbjct: 248 IGLGNNQFASIPNQLADTHG-------LPRVFSLCFGSFEGGGALSFGRLPATPHTPPLV 300 Query: 389 WVPM-VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG---IVDSGTT 520 + M V + P+YY T ++IGD L G ++DSGTT Sbjct: 301 YTDMRVNEAHPAYYVVS-TAAMKIGDVAVATPSDLAVGYGTVMDSGTT 347 [72][TOP] >UniRef100_B4PWZ4 GE16588 n=1 Tax=Drosophila yakuba RepID=B4PWZ4_DROYA Length = 408 Score = 54.7 bits (130), Expect = 5e-06 Identities = 47/163 (28%), Positives = 82/163 (50%), Gaps = 8/163 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDS-PDFERSTVDGILGLAWPKLA 241 F + +G GS SG L +D++ + FG + + +F + DGILG+ +P LA Sbjct: 134 FSILYGTGS-VSGYLSVDSVGFAGLTVQSQTFGEVTTEQGTNFVDAYFDGILGMGFPSLA 192 Query: 242 CNPSCVEPTFDAMVRHLKIDN-IFSM------CITGTGGKLVLGGHDTTLAKADPVWVPM 400 + V PTF M++ + + +FS +T GG+L+LGG D++L + + Sbjct: 193 VDG--VTPTFQNMIQQGLVQSPVFSFFLRDNGSVTFYGGELILGGSDSSLYSGYLTYTDV 250 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 + +Y+ F+ T ++IG T + I D+GT+LI+ Sbjct: 251 I---ETAYWKFQ-TDYIKIG---TTFISTFAAAIADTGTSLII 286 [73][TOP] >UniRef100_C5NN35 Putative aspartic protease n=1 Tax=Lentinula edodes RepID=C5NN35_LENED Length = 423 Score = 54.7 bits (130), Expect = 5e-06 Identities = 36/127 (28%), Positives = 55/127 (43%), Gaps = 11/127 (8%) Frame = +2 Query: 17 SATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNLTWGNNITFPVVFG 163 S + CS + N G F + +GDGS SG + D +T Sbjct: 142 SCKSSVCSSKHKYNAGSSSTSKKLSGTFSIQYGDGSSVSGPIYDDTVTVAGITVTEQTLS 201 Query: 164 GILKDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITGTGGKL 343 G+ + S DFE DG+ G A+PK++ N +A ++ N FS+ + G +L Sbjct: 202 GVTELSSDFENDPTDGVFGFAYPKIS-NLQANTFFVNAFLQDAVSSNEFSLFLASFGSEL 260 Query: 344 VLGGHDT 364 LGG +T Sbjct: 261 FLGGTNT 267 [74][TOP] >UniRef100_B8P867 Predicted protein (Fragment) n=1 Tax=Postia placenta Mad-698-R RepID=B8P867_POSPM Length = 306 Score = 54.7 bits (130), Expect = 5e-06 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 5/180 (2%) Frame = +2 Query: 2 SCGKCSATKA---CCSKLNTDNCG-FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGI 169 SC C A + S +++ G F +S+GDGS ASG + D ++ + Sbjct: 49 SCSGCQAKHSYDPSSSSTSSEQSGTFQISYGDGSQASGPIFTDTVSVSGVTVTGQYLSAV 108 Query: 170 LKDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDN-IFSMCITGTGGKLV 346 +S + DG++G+A+P A + P F + V +D+ +F ++ +G +L Sbjct: 109 TSESGNLVGGPNDGLMGMAFP--AISQLGHNPFFQSAVSEKAVDSGVFGFKLSSSGAQLN 166 Query: 347 LGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 LGG D++L + L S Y+ L G +++ + I+DSGTTL+ Sbjct: 167 LGGTDSSLYSGSIEYHD--LASTAGYWQIGGASALVNGKAVVSDI----QTIIDSGTTLM 220 [75][TOP] >UniRef100_Q800A0 Cathepsin E n=1 Tax=Rana catesbeiana RepID=CATE_RANCA Length = 397 Score = 54.7 bits (130), Expect = 5e-06 Identities = 49/161 (30%), Positives = 79/161 (49%), Gaps = 7/161 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLT-WGNNITFPVVFGGILKDSPDFERSTVDGILGLAWPKLA 241 F + +G G+ +G L ID +T G + + + F+ S DGILGLA+P LA Sbjct: 131 FFIQYGTGN-LTGILGIDQVTVQGITVQSQTFAESVSEPGSTFQDSNFDGILGLAYPNLA 189 Query: 242 CNPSCVEPTFDAMVRHLKID-NIFSMCI-----TGTGGKLVLGGHDTTLAKADPVWVPMV 403 + +C+ P FD M+ ++ +F + + + GG+LVLGG DT+ WVP+ Sbjct: 190 VD-NCI-PVFDNMIAQNLVELPLFGVYMNRDPNSADGGELVLGGFDTSRFSGQLNWVPIT 247 Query: 404 LRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 ++ Y+ +V G + IVD+GT+LI Sbjct: 248 VQ---GYWQIQVDSIQVAG--QVIFCSDGCQAIVDTGTSLI 283 [76][TOP] >UniRef100_O93428 Cathepsin D n=1 Tax=Chionodraco hamatus RepID=CATD_CHIHA Length = 396 Score = 54.7 bits (130), Expect = 5e-06 Identities = 51/161 (31%), Positives = 83/161 (51%), Gaps = 7/161 (4%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKD-SPDFERSTVDGILGLAWPKLA 241 F + +G GS SG L D T G+ +FG +K F + DGILG+A+P+++ Sbjct: 135 FAIQYGSGS-LSGYLSQDTCTIGDLAIDSQLFGEAIKQPGVAFIAAKFDGILGMAYPRIS 193 Query: 242 CNPSCVEPTFDAMVRHLKID-NIFSMCI-----TGTGGKLVLGGHDTTLAKADPVWVPMV 403 + V P FD ++ K++ N+FS + T GG+L+LGG D D +V + Sbjct: 194 VDG--VAPVFDNIMSQKKVEQNVFSFYLNRNPDTEPGGELLLGGTDPKYYTGDFNYVNVT 251 Query: 404 LRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 + +Y+ +V + +GD+ + + IVDSGT+LI Sbjct: 252 RQ---AYWQIRVDS-MAVGDQ-LSLCTGGCEAIVDSGTSLI 287 [77][TOP] >UniRef100_UPI000069E2EB Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2). n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E2EB Length = 397 Score = 54.3 bits (129), Expect = 6e-06 Identities = 53/182 (29%), Positives = 82/182 (45%), Gaps = 20/182 (10%) Frame = +2 Query: 35 CSKLNTD-NCGFHLSFGDGSGASGELVIDNLT--WGNNITFPVVFGGILKDSPDF-ERST 202 CS+ D G ++ + G GEL D +T G N+T I F S Sbjct: 13 CSRTYRDVRRGVYVPYTQGKW-EGELGTDLVTIPHGPNVTVTANIAAITDSDKFFINGSN 71 Query: 203 VDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITGT-------------GGKL 343 +GILGLA+ ++A +EP FD++V+ ++ NIFS+ + GT GG + Sbjct: 72 WEGILGLAYAEIARPDDTLEPFFDSLVKQTRVPNIFSLQLCGTGFHFNESDTSASVGGSM 131 Query: 344 VLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDA---TELPPLRKGIVDSG 514 V+GG D +L +W + + +Y + + I +D + K IVDSG Sbjct: 132 VIGGIDPSL-YIGSIWYTPIRK---EWYYEVIIVKIEINGQDLHMDCKEYNYDKSIVDSG 187 Query: 515 TT 520 TT Sbjct: 188 TT 189 [78][TOP] >UniRef100_Q9JJX2 Pepsinogen F protein n=1 Tax=Rattus norvegicus RepID=Q9JJX2_RAT Length = 387 Score = 54.3 bits (129), Expect = 6e-06 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 5/158 (3%) Frame = +2 Query: 68 HLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDF-ERSTVDGILGLAWPKLAC 244 ++++G G SG L D + G+ FG L++ F E + DGILGL +P L Sbjct: 132 NVAYGSGE-MSGFLAYDTVKIGDLTVVAQAFGLSLEEPGRFMEHAVFDGILGLGYPNLGL 190 Query: 245 NPSCVEPTFDAM-VRHLKIDNIFSMCITG---TGGKLVLGGHDTTLAKADPVWVPMVLRS 412 V P FD + ++ L N+F+ ++ G L+LGG D + + WVP+ S Sbjct: 191 QG--VTPVFDNLWIQGLIPQNLFAFYLSSKDEKGSVLMLGGVDPSYYHGELHWVPV---S 245 Query: 413 PPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 PSY+ V G+ A + +GI+D+GT+L+ Sbjct: 246 KPSYWQLAVDSISMNGEIIACD--GGCQGIMDTGTSLV 281 [79][TOP] >UniRef100_Q9GK11 Chymosin n=1 Tax=Camelus dromedarius RepID=Q9GK11_CAMDR Length = 381 Score = 54.3 bits (129), Expect = 6e-06 Identities = 50/134 (37%), Positives = 66/134 (49%), Gaps = 6/134 (4%) Frame = +2 Query: 56 NCGFHLSFGDGSGA-SGELVIDNLTWGNNITFPVVFGGILKDSPD--FERSTVDGILGLA 226 N G LS G+G+ G L D +T +NI P G+ + P F S DGILGLA Sbjct: 126 NLGKPLSIHYGTGSMEGFLGYDTVTV-SNIVDPNQTVGLSTEQPGEVFTYSEFDGILGLA 184 Query: 227 WPKLACNPSCVEPTFDAMV-RHLKIDNIFSMCI--TGTGGKLVLGGHDTTLAKADPVWVP 397 +P LA S P FD M+ RHL ++FS+ + G G L LG D + WVP Sbjct: 185 YPSLASEYSV--PVFDNMMDRHLVARDLFSVYMDRNGQGSMLTLGAIDPSYYTGSLHWVP 242 Query: 398 MVLRSPPSYYPFKV 439 + L+ Y+ F V Sbjct: 243 VTLQ---QYWQFTV 253 [80][TOP] >UniRef100_A3F4M4 Preprochymosin n=1 Tax=Capra hircus RepID=A3F4M4_CAPHI Length = 381 Score = 54.3 bits (129), Expect = 6e-06 Identities = 54/163 (33%), Positives = 77/163 (47%), Gaps = 5/163 (3%) Frame = +2 Query: 56 NCGFHLSFGDGSGA-SGELVIDNLTWGNNITFPVVFGGILKDSPD-FERSTVDGILGLAW 229 N G LS G+G+ G L D +T N + G ++ D F + DGILG+A+ Sbjct: 126 NLGKPLSIRYGTGSMQGILGYDTVTVSNIVDTQQTVGLSTQEPGDVFTYAEFDGILGMAY 185 Query: 230 PKLACNPSCVEPTFDAMV-RHLKIDNIFSMCI--TGTGGKLVLGGHDTTLAKADPVWVPM 400 P LA S P FD M+ RHL ++FS+ + G G L LG D + WVP+ Sbjct: 186 PSLASEYSV--PVFDNMMDRHLVAQDLFSVYMDRNGQGSMLTLGAIDPSYYTGSLHWVPV 243 Query: 401 VLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLIV 529 L+ Y+ F V G A E + I+D+GT+ +V Sbjct: 244 TLQ---KYWQFTVDSVTISGAVVACE--GGCQAILDTGTSKLV 281 [81][TOP] >UniRef100_C3XQC3 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3XQC3_BRAFL Length = 392 Score = 54.3 bits (129), Expect = 6e-06 Identities = 52/175 (29%), Positives = 85/175 (48%), Gaps = 7/175 (4%) Frame = +2 Query: 23 TKACCSKLNTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPD-FERS 199 +K+C K D +++G GS SG L D + G+ + FG + F Sbjct: 119 SKSCTYK--ADGRPLKITYGSGS-LSGFLSQDVVMIGSIVIKNQTFGEATNEPGSAFATG 175 Query: 200 TVDGILGLAWPKLACNPSCVEPTFDAMVRHLKID-NIFSMCI-----TGTGGKLVLGGHD 361 DGILGLA+P++A + + P FD ++ +D N+FS + GG+L+LGG D Sbjct: 176 KFDGILGLAYPQIAVDH--IRPVFDMIMDQKLVDKNVFSFYLDRDPSRAPGGELLLGGTD 233 Query: 362 TTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTTLI 526 T + ++P+ S Y+ + G + +GD+ + IVD+GT+LI Sbjct: 234 PTYYTGNFTYIPV---SYQGYWQLNMDG-VHVGDQKL--CAGGCQAIVDTGTSLI 282 [82][TOP] >UniRef100_O74665 SAP2 (Fragment) n=1 Tax=Rhizopus oryzae RepID=O74665_RHIOR Length = 280 Score = 54.3 bits (129), Expect = 6e-06 Identities = 47/183 (25%), Positives = 84/183 (45%), Gaps = 7/183 (3%) Frame = +2 Query: 2 SCGKCSATKACCSKLNT---DNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGIL 172 +CG S TK ++ +T D + +S+GDGS ASG L D +T G Sbjct: 19 NCGS-SQTKYNPNESSTYARDGRTWSISYGDGSSASGILGTDTVTLGGLTITHQTIELAR 77 Query: 173 KDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGGK 340 +++ F+ DG+LGL + + P + + + L + +F + + G GG+ Sbjct: 78 REASQFQSGPSDGLLGLGFDSITTVRGVTTPVDNLISQGLISNPVFGVYLGKENNGGGGE 137 Query: 341 LVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGTT 520 + GG+D++ K +P + + +Y V G G R ++ I+D+GT+ Sbjct: 138 YIFGGYDSSKFKGSLTTIP--VDNSNGWYGITVRGASIGGSRVSSSF----DAILDTGTS 191 Query: 521 LIV 529 L+V Sbjct: 192 LLV 194 [83][TOP] >UniRef100_Q4UHM4 Pepsinogen, putative n=1 Tax=Theileria annulata RepID=Q4UHM4_THEAN Length = 519 Score = 53.9 bits (128), Expect = 8e-06 Identities = 38/120 (31%), Positives = 60/120 (50%), Gaps = 1/120 (0%) Frame = +2 Query: 47 NTDNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPD-FERSTVDGILGL 223 N N G + FG G G L IDN+T GN+I +FG + +++ + F GI+GL Sbjct: 218 NPINEGLKIKFGTGI-IKGVLGIDNITIGNDIIKQQIFGLVNEENSNIFNVIKFQGIIGL 276 Query: 224 AWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCITGTGGKLVLGGHDTTLAKADPVWVPMV 403 +PKLA + +D + + D IFS+ + L++GG D K D +P++ Sbjct: 277 GFPKLAFDHHT--SLYDNYSKQINADLIFSLYFSNQYSYLMMGGIDKRFYKGDLYMLPVI 334 [84][TOP] >UniRef100_B4P123 GE18491 n=1 Tax=Drosophila yakuba RepID=B4P123_DROYA Length = 392 Score = 53.9 bits (128), Expect = 8e-06 Identities = 61/190 (32%), Positives = 83/190 (43%), Gaps = 18/190 (9%) Frame = +2 Query: 14 CSATKACCSKLNTDNCG-----------FHLSFGDGSGASGELVIDNLTWGNNITFPVVF 160 C A+ C K N N F + +G GS SG L D +T F Sbjct: 107 CPASNIACKKHNKYNSAASSTYVANGEEFAIEYGTGS-LSGILSTDTVTIAGISIQDQTF 165 Query: 161 GGILKD-SPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDN---IFSMCITG 328 G L + F + GILGLA+ +A + V P FD MV +D F + G Sbjct: 166 GEALNEPGTTFVDAPFAGILGLAFSAIAVDG--VTPPFDNMVSQGLLDEPVISFYLKRQG 223 Query: 329 T---GGKLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKG 499 T GG+L+LGG D++L K +VP+ S P+Y+ F V G L + Sbjct: 224 TAVRGGELILGGIDSSLYKGSLTYVPV---SVPAYWQFAVNTIKTNG----IVLCNGCQA 276 Query: 500 IVDSGTTLIV 529 I D+GT+LIV Sbjct: 277 IADTGTSLIV 286 [85][TOP] >UniRef100_A8XXJ9 C. briggsae CBR-ASP-1 protein n=1 Tax=Caenorhabditis briggsae AF16 RepID=A8XXJ9_CAEBR Length = 393 Score = 53.9 bits (128), Expect = 8e-06 Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 5/132 (3%) Frame = +2 Query: 65 FHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGILKDSPDFERSTVDGILGLAWPKLAC 244 F + +G GS +G L D +T+G FG + F VDGILGL WP LA Sbjct: 132 FSIQYGSGS-CNGYLGTDTITFGGLTIKSQEFGVATHLAEVFGYQPVDGILGLGWPALAV 190 Query: 245 NP-----SCVEPTFDAMVRHLKIDNIFSMCITGTGGKLVLGGHDTTLAKADPVWVPMVLR 409 + V P DA + + +D ++ G+GG + G DTT + +VP+ + Sbjct: 191 DKVVPPMQNVLPQLDAPLFTVWLDRKLTISQGGSGGLITYGAVDTTNCDSQITYVPLTAK 250 Query: 410 SPPSYYPFKVTG 445 +Y+ F + G Sbjct: 251 ---TYWQFALDG 259 [86][TOP] >UniRef100_P10602 Rhizopuspepsin-1 n=2 Tax=Rhizopus RepID=CARP1_RHINI Length = 389 Score = 53.9 bits (128), Expect = 8e-06 Identities = 50/184 (27%), Positives = 82/184 (44%), Gaps = 9/184 (4%) Frame = +2 Query: 5 CGKCSA--TKACCSKLNT---DNCGFHLSFGDGSGASGELVIDNLTWGNNITFPVVFGGI 169 C CS TK K +T D + +S+GDGS ASG L DN+ G + Sbjct: 113 CSSCSNSHTKYDPKKSSTYAADGRTWSISYGDGSSASGILATDNVNLGGLLIKKQTIELA 172 Query: 170 LKDSPDFERSTVDGILGLAWPKLACNPSCVEPTFDAMVRHLKIDNIFSMCI----TGTGG 337 ++S F +DG+LGL + + P + + + L IF + + G GG Sbjct: 173 KRESSAFATDVIDGLLGLGFNTITTVRGVKTPVDNLISQGLISRPIFGVYLGKQSNGGGG 232 Query: 338 KLVLGGHDTTLAKADPVWVPMVLRSPPSYYPFKVTGPLRIGDRDATELPPLRKGIVDSGT 517 + + GG+D++ K VP + + ++ V +IG T + I+D+GT Sbjct: 233 EYIFGGYDSSKFKGSLTTVP--IDNSEGFWGVTVKS-TKIG---GTTVSASFDAILDTGT 286 Query: 518 TLIV 529 TL++ Sbjct: 287 TLLL 290