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[1][TOP]
>UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum
RepID=TOP1_DICDI
Length = 893
Score = 135 bits (340), Expect = 2e-30
Identities = 66/156 (42%), Positives = 96/156 (61%), Gaps = 1/156 (0%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 242
E E +G +WW+ + D KWTTL HNG FPP Y PHG +Y+G + L P EE
Sbjct: 289 EEEEEEGVNKWWDKEDDEDDGTKWTTLIHNGPVFPPAYVPHGIKFMYDGKVVKLTPKQEE 348
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 422
VATFYA+ L+TDHV K+ F+ NFF +F+ LL + +++ ++KCDFS I HL+ +K
Sbjct: 349 VATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKE 407
Query: 423 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDG 527
++KA K E K+A AE +++++ A +DG
Sbjct: 408 QRKARSK-----EEKDAETAEKKKIQEKHGFATIDG 438
[2][TOP]
>UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus
RepID=A5E508_LODEL
Length = 849
Score = 135 bits (339), Expect = 2e-30
Identities = 70/157 (44%), Positives = 97/157 (61%), Gaps = 3/157 (1%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 242
E D G++WWEA ++ DGE+KWT+LEHNGV FPPEYE P L Y+G ++LP AEE
Sbjct: 207 EEEDAGYKWWEAQDEHDGEIKWTSLEHNGVMFPPEYEPLPSHVKLYYDGKPVNLPVEAEE 266
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 419
VA F+ + ++TDH F+ NFF DF+ +L ++ V I EK DFS+I A+ E
Sbjct: 267 VAGFFGAMVETDHAKNPVFQKNFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE--- 323
Query: 420 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK+ EKKA + E+K +E + F L++GR
Sbjct: 324 -KKREEKKAMSREEKKRLKEEKDRIEEPFKTCLLNGR 359
[3][TOP]
>UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa
FA553 RepID=UPI000187E0BD
Length = 265
Score = 132 bits (331), Expect = 2e-29
Identities = 74/178 (41%), Positives = 102/178 (57%), Gaps = 4/178 (2%)
Frame = +3
Query: 9 EDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP-- 182
E+ T SP + G E E + ++WWE N+ D VKWTTLEHNGV FPP YEP
Sbjct: 46 EETTSSPTKGKGKK--RKEDEEQEDVYKWWENNNE-DSSVKWTTLEHNGVIFPPPYEPLP 102
Query: 183 HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAK 356
+ Y+G L+LPP +EEVA FYA+ ++TDH F NFF D+ +L D +
Sbjct: 103 SNVKMKYDGKVLNLPPESEEVAGFYAALIETDHAQDATFNKNFFEDWLKVLQDHPPRNGI 162
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+T +KCDF + + E EKAK KKA + AE+KE ++ + E ++T +DGR
Sbjct: 163 KVTDFDKCDFRPMYEYFEAEKAK----KKAMSAAEKKEIKKQKDEAEAKYTHCFLDGR 216
[4][TOP]
>UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36
RepID=B9WIH6_CANDC
Length = 777
Score = 127 bits (319), Expect = 5e-28
Identities = 72/187 (38%), Positives = 98/187 (52%), Gaps = 11/187 (5%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENG--------DGGFRWWEAGNKTDGEVKWTTLEHNGV 158
K E +T S + P ++ + D G++WWEA +TD +KW TLEHNGV
Sbjct: 105 KKESKTASSTKVKEEPKSQSDSQASVKSETPEEDQGYKWWEANEETDDIIKWQTLEHNGV 164
Query: 159 YFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRAL 332
FPP YE P L Y ++LPP AEEVA FY + L+TDH F+ NFF DF +
Sbjct: 165 IFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDFLEV 224
Query: 333 LADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 509
L + V I EK DFS++ AH E K + EKKA + E+K +E + + F
Sbjct: 225 LKECGGCGVEIKDFEKLDFSKMYAHFE----KLREEKKAMSKEEKKRIKEEKEKEEEPFK 280
Query: 510 VALVDGR 530
++GR
Sbjct: 281 TCYLNGR 287
[5][TOP]
>UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404
RepID=C5M985_CANTT
Length = 777
Score = 125 bits (313), Expect = 2e-27
Identities = 66/154 (42%), Positives = 92/154 (59%), Gaps = 3/154 (1%)
Frame = +3
Query: 78 DGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVAT 251
D G++WWEA +T+G +KW TLEHNGV FPPEYE P L Y+G ++LPP AEEVA
Sbjct: 138 DEGYKWWEATEETEGGIKWETLEHNGVIFPPEYEPLPSHVKLYYDGKPVNLPPEAEEVAG 197
Query: 252 FYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKK 428
FY + L+TDH F+ NFF DF +L + V I EK DFS++ A+ E ++
Sbjct: 198 FYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKEFEKMDFSKMYAYYE----QQ 253
Query: 429 KAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+ EKKA + E+K +E + + ++GR
Sbjct: 254 REEKKALSRDEKKRLKEERDKFEEPYKTCYLNGR 287
[6][TOP]
>UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI
Length = 760
Score = 124 bits (310), Expect = 5e-27
Identities = 72/166 (43%), Positives = 101/166 (60%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLI--YEGMELHLPPAA 236
E E + ++WWE N+ D +KW TLEH GV FPPEYEP ++ Y+G + LP AA
Sbjct: 113 ETEEAEDVYKWWENDNQDDS-IKWETLEHKGVMFPPEYEPLPKSVLMKYDGTPVVLPHAA 171
Query: 237 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI 395
EEVA F+ + L+TDH F+ NFF DF+A+L ++ AK I + KCDFS +
Sbjct: 172 EEVAGFFGAMLETDHAKNPTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDM 231
Query: 396 EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGR 530
AH E K + EKKA + AE+K A +AE +++ + F V L++GR
Sbjct: 232 YAHFE----KMREEKKAMSAAEKK-AIKAERDKIEEPFKVCLLNGR 272
[7][TOP]
>UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983
RepID=C5LJG7_9ALVE
Length = 551
Score = 122 bits (307), Expect = 1e-26
Identities = 65/145 (44%), Positives = 91/145 (62%)
Frame = +3
Query: 90 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 269
RWWE + D KW+ LEH+G+ F P YEPHG ++Y+G + LPP AEEVATF+A L
Sbjct: 83 RWWEK-DPEDNAAKWSYLEHHGMIFTPPYEPHGVKMLYKGEPIDLPPEAEEVATFFAQTL 141
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ K+ KKA+
Sbjct: 142 GTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD----KRSEAKKAR 196
Query: 450 TTAERKEAREAEAERVRQFTVALVD 524
T E++ +EA+ +T +VD
Sbjct: 197 TKEEKEAEKEAKRLNDHPYTHVIVD 221
[8][TOP]
>UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983
RepID=C5L755_9ALVE
Length = 647
Score = 122 bits (307), Expect = 1e-26
Identities = 65/145 (44%), Positives = 91/145 (62%)
Frame = +3
Query: 90 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 269
RWWE + D KW+ LEH+G+ F P YEPHG ++Y+G + LPP AEEVATF+A L
Sbjct: 83 RWWEK-DPEDNAAKWSYLEHHGMIFTPPYEPHGVKMLYKGEPIDLPPEAEEVATFFAQTL 141
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ K+ KKA+
Sbjct: 142 GTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD----KRSEAKKAR 196
Query: 450 TTAERKEAREAEAERVRQFTVALVD 524
T E++ +EA+ +T +VD
Sbjct: 197 TKEEKEAEKEAKRLNDHPYTHVIVD 221
[9][TOP]
>UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe
RepID=TOP1_SCHPO
Length = 814
Score = 122 bits (305), Expect = 2e-26
Identities = 63/156 (40%), Positives = 91/156 (58%), Gaps = 2/156 (1%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 242
E+ D ++WW + N D + KWTTLEHNGV F P YEP LIY+G ++LPP AEE
Sbjct: 175 EDEDEDYKWWTSENIDDTQ-KWTTLEHNGVIFAPPYEPLPKNVKLIYDGNPVNLPPEAEE 233
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 422
VA FYA+ L+TDH F+ NFF DF + + F I KCDF+++ H E
Sbjct: 234 VAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFE---- 289
Query: 423 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+K+ EKK+ ++K ++ + E ++ ++DGR
Sbjct: 290 QKREEKKSMPKEQKKAIKQKKDEEEEKYKWCILDGR 325
[10][TOP]
>UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans
RepID=Q59XR0_CANAL
Length = 780
Score = 121 bits (304), Expect = 3e-26
Identities = 70/181 (38%), Positives = 98/181 (54%), Gaps = 5/181 (2%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTTLEHNGVYFPPEY 176
K E +T S +A+ +E D G++WWE + +G+ +KW TLEHNGV FPP Y
Sbjct: 118 KEESKTQSDSQASVK----SETPEEDQGYKWWEVNQEEEGDGYIKWQTLEHNGVMFPPPY 173
Query: 177 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 350
EP L Y ++LPP AEEVA FY + L+TDH F+ NFF DF +L +
Sbjct: 174 EPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGG 233
Query: 351 AKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
V I EK DFS++ AH E K + EKKA + E+K +E + + + ++G
Sbjct: 234 CGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNG 289
Query: 528 R 530
R
Sbjct: 290 R 290
[11][TOP]
>UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL
Length = 778
Score = 121 bits (304), Expect = 3e-26
Identities = 70/181 (38%), Positives = 98/181 (54%), Gaps = 5/181 (2%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTTLEHNGVYFPPEY 176
K E +T S +A+ +E D G++WWE + +G+ +KW TLEHNGV FPP Y
Sbjct: 116 KEESKTQSDSQASVK----SETPEEDQGYKWWEVNQEEEGDGYIKWQTLEHNGVMFPPPY 171
Query: 177 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 350
EP L Y ++LPP AEEVA FY + L+TDH F+ NFF DF +L +
Sbjct: 172 EPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGG 231
Query: 351 AKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
V I EK DFS++ AH E K + EKKA + E+K +E + + + ++G
Sbjct: 232 CGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNG 287
Query: 528 R 530
R
Sbjct: 288 R 288
[12][TOP]
>UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans
RepID=Q59WV6_CANAL
Length = 780
Score = 120 bits (302), Expect = 5e-26
Identities = 70/181 (38%), Positives = 98/181 (54%), Gaps = 5/181 (2%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTTLEHNGVYFPPEY 176
K E +T S +A+ +E D G++WWE + +G+ +KW TLEHNGV FPP Y
Sbjct: 118 KEESKTQSDSQASVK----SETLEEDQGYKWWEVNQEEEGDGYIKWQTLEHNGVMFPPPY 173
Query: 177 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 350
EP L Y ++LPP AEEVA FY + L+TDH F+ NFF DF +L +
Sbjct: 174 EPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGG 233
Query: 351 AKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
V I EK DFS++ AH E K + EKKA + E+K +E + + + ++G
Sbjct: 234 CGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNG 289
Query: 528 R 530
R
Sbjct: 290 R 290
[13][TOP]
>UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum
RepID=Q0UUB0_PHANO
Length = 887
Score = 120 bits (302), Expect = 5e-26
Identities = 76/168 (45%), Positives = 89/168 (52%), Gaps = 10/168 (5%)
Frame = +3
Query: 57 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 230
AAE E + +RWWE K DG KW TLEHNGV FPPEY P LIY+G+ + L P
Sbjct: 234 AAEDEEEE--YRWWEDTAKGDGSKKWDTLEHNGVVFPPEYVPLPKNVKLIYDGIPVTLQP 291
Query: 231 AAEEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDF 386
AEE ATFY S L + H V F NFF DF A+L T K I EKCDF
Sbjct: 292 EAEEAATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDF 351
Query: 387 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I H E ++A KKA A+ A + E AEAE + + DGR
Sbjct: 352 KPIFEHFEADRAAKKALPAAEKKALKAEKDAAEAE----YMFCMWDGR 395
[14][TOP]
>UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea
okayama7#130 RepID=A8N6Y9_COPC7
Length = 863
Score = 120 bits (302), Expect = 5e-26
Identities = 68/161 (42%), Positives = 91/161 (56%), Gaps = 5/161 (3%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKT-DGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPA 233
E E + F+WWEAG+ DG KW TLEHNGVYFPP YE P + Y G ++ L
Sbjct: 234 EEEEEEEVFKWWEAGDVNGDGTQKWETLEHNGVYFPPPYEALPKHVKMKYNGKDVDLSIE 293
Query: 234 AEEVATFYASKLQTDHVLKEKFRSNFFADFRALLA--DTKFAKVITSLEKCDFSRIEAHL 407
AEEVA FY + L+TDH F NFF DF+ +L + IT+ E CDF + +
Sbjct: 294 AEEVAGFYGALLETDHAKDATFNKNFFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYF 353
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
E EKAK +KA T E+K A++ + E ++ ++DGR
Sbjct: 354 EAEKAK----RKAMTNEEKKAAKKKKDELEEKYKTCVMDGR 390
[15][TOP]
>UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum
RepID=Q94705_PHYPO
Length = 1015
Score = 120 bits (300), Expect = 8e-26
Identities = 68/156 (43%), Positives = 95/156 (60%), Gaps = 1/156 (0%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 242
EGE G+ ++WWE DG+ +WT+L HNGV F Y HG Y+G ++L P AEE
Sbjct: 391 EGE-GEEEWKWWEEEALPDGK-RWTSLVHNGVVFVEPYVAHGVKFYYDGKPINLSPEAEE 448
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 422
VATFYA L+TD+ KE F +NF++DFR L + KVI K DF+ I +L ++K
Sbjct: 449 VATFYAKYLETDYPKKENFNTNFWSDFRTYLTPEQ-KKVIKDFSKADFTHIHKYLVEQK- 506
Query: 423 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDG 527
E KA TAE K+A +AE E++ Q + A+++G
Sbjct: 507 ----ELKANRTAEEKKAEKAEKEKLLQKYGFAMING 538
[16][TOP]
>UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST
Length = 780
Score = 119 bits (298), Expect = 1e-25
Identities = 67/148 (45%), Positives = 88/148 (59%), Gaps = 3/148 (2%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 242
E+ D G++WWEA + DG KW TLEHNGV FPPEYEP L Y+G + L AEE
Sbjct: 137 EDEDEGYKWWEAED-VDGVQKWETLEHNGVLFPPEYEPLPSHVKLYYDGKPVKLSLEAEE 195
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 419
VA FY + L+TDH F+ NFF DF ++ +T + V I EK DFS+I AH E
Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE--- 252
Query: 420 AKKKAEKKAQTTAERKEAREAEAERVRQ 503
K E+K T ++K+A + E ER+ +
Sbjct: 253 --KLREEKKLLTKDQKKAMKEEKERIEE 278
[17][TOP]
>UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275
RepID=B6JVY3_SCHJY
Length = 654
Score = 119 bits (297), Expect = 2e-25
Identities = 68/170 (40%), Positives = 95/170 (55%), Gaps = 4/170 (2%)
Frame = +3
Query: 33 RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYE 206
+ +GS + + E +G F+WWE + DG+ KW TLEHNGV FPPEYEP ++Y
Sbjct: 209 KMSGSIRSSPKTEEENGDFKWWET-DLPDGK-KWNTLEHNGVMFPPEYEPLPSHVKMLYN 266
Query: 207 GMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKC 380
G + LPPAAEEVA F+ + L++DH F+ NFF DF+A+ A K A + C
Sbjct: 267 GKPIDLPPAAEEVAGFFGALLESDHAQNPTFQKNFFRDFQAVCKEAGMKSADIPKEFNSC 326
Query: 381 DFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
DF + + E K KK K E+KE ++ + E +F L+DGR
Sbjct: 327 DFRPMFEYFESLKEAKKNMSK----EEKKELKKKKEEEEEKFKWCLLDGR 372
[18][TOP]
>UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans
RepID=Q5KB99_CRYNE
Length = 881
Score = 118 bits (296), Expect = 2e-25
Identities = 68/161 (42%), Positives = 91/161 (56%), Gaps = 5/161 (3%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 236
E E + ++WWE DG KWT LEHN V FPP Y P + Y+G+ L LPP +
Sbjct: 236 EEEEEEERYKWWEQDALGDGSSKWTVLEHNAVLFPPPYVPLPKNVKMKYDGVSLTLPPES 295
Query: 237 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLE 410
EEVA F+ + L+TD+ KFR NFF DF+A++ K + LEKCDF + + E
Sbjct: 296 EEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFE 355
Query: 411 DEKAKKKAEKKAQTTAERKEAREAEAERVR-QFTVALVDGR 530
EK KKKA T E K+A +AE +++ + A VDGR
Sbjct: 356 KEKEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGR 391
[19][TOP]
>UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans
RepID=O59891_CRYNE
Length = 844
Score = 118 bits (295), Expect = 3e-25
Identities = 68/161 (42%), Positives = 91/161 (56%), Gaps = 5/161 (3%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 236
E E + ++WWE DG KWT LEHN V FPP Y P + Y+G+ L LPP +
Sbjct: 199 EEEEEEEKYKWWEQDALGDGSSKWTVLEHNAVLFPPPYVPLPKDVKMKYDGVSLTLPPES 258
Query: 237 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLE 410
EEVA F+ + L+TD+ KFR NFF DF+A++ K + LEKCDF + + E
Sbjct: 259 EEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFE 318
Query: 411 DEKAKKKAEKKAQTTAERKEAREAEAERVR-QFTVALVDGR 530
EK KKKA T E K+A +AE +++ + A VDGR
Sbjct: 319 KEKEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGR 354
[20][TOP]
>UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224
RepID=B6QNQ2_PENMQ
Length = 860
Score = 116 bits (290), Expect = 1e-24
Identities = 71/181 (39%), Positives = 96/181 (53%), Gaps = 14/181 (7%)
Frame = +3
Query: 30 GRAAGSPLGA----AEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGF 191
G+ +P+ A EG + +RWWE K DG +KW TLEHNGV FPPEYE P
Sbjct: 192 GKGKATPVKAESEDVEGAEEEEEYRWWEDPTKGDGTIKWNTLEHNGVVFPPEYEPLPKNV 251
Query: 192 PLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV--- 359
+ Y+G+ + L P AEEVA F+ + L + H V F+ NFF DF+A+L T AK
Sbjct: 252 KMKYDGVPVVLHPEAEEVAGFFGAMLNSTHNVENPTFQKNFFEDFKAILKKTGGAKTQKG 311
Query: 360 ----ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
I +KCDF I + E ++ +KK A+ A + E EAEA + + DG
Sbjct: 312 EPINIKEFKKCDFKPIFEYYEGKRLEKKNLSAAEKKALKAERDEAEA----PYMYCIWDG 367
Query: 528 R 530
R
Sbjct: 368 R 368
[21][TOP]
>UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143
RepID=C6HAF8_AJECH
Length = 909
Score = 115 bits (288), Expect = 2e-24
Identities = 67/166 (40%), Positives = 91/166 (54%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
EGE+ + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 256 EGEDAEEEYRWWEDPAKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEA 315
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + ++ AK I S +KCDF
Sbjct: 316 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKP 375
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + E + EKK+ +AE+K + + E + + DGR
Sbjct: 376 IFEYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGR 417
[22][TOP]
>UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR
RepID=C0NC53_AJECG
Length = 909
Score = 115 bits (288), Expect = 2e-24
Identities = 67/166 (40%), Positives = 91/166 (54%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
EGE+ + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 256 EGEDAEEEYRWWEDPAKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEA 315
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + ++ AK I S +KCDF
Sbjct: 316 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKP 375
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + E + EKK+ +AE+K + + E + + DGR
Sbjct: 376 IFEYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGR 417
[23][TOP]
>UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP
RepID=B2WCA4_PYRTR
Length = 905
Score = 115 bits (288), Expect = 2e-24
Identities = 71/166 (42%), Positives = 87/166 (52%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E + + +RWW+ K DG KW TLEH GV FPPEYE P L+Y+G+ + L A
Sbjct: 252 EAADEEDEYRWWDDPGKNDGTKKWDTLEHAGVVFPPEYEPLPKHVKLVYDGVPVTLHKDA 311
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVATFY S L + H V F NFF DF A+L T K I EKCDF
Sbjct: 312 EEVATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKP 371
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + E+AKKKA A+ A + E AEA+ + L DGR
Sbjct: 372 IFEWFDAERAKKKALSAAEKKALKAEKEAAEAD----YMYCLWDGR 413
[24][TOP]
>UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
topoisomerase I n=1 Tax=Candida glabrata
RepID=Q6FNH4_CANGA
Length = 744
Score = 115 bits (287), Expect = 2e-24
Identities = 63/153 (41%), Positives = 89/153 (58%), Gaps = 5/153 (3%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE K D +KW +L+HNGV FPPEYEP L Y+G + LPPAAEEVA F+A
Sbjct: 106 YKWWE-NEKNDDTIKWVSLKHNGVLFPPEYEPLPSHVKLYYDGKPVDLPPAAEEVAGFFA 164
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK 431
+ L TDH F+ NFF DF +L + T+ IT +KCDFS++ + E KK
Sbjct: 165 NLLHTDHAKNPVFQKNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFE----LKK 220
Query: 432 AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
EK+ + E+K+ + + + +F +DGR
Sbjct: 221 EEKRNMSREEKKQIKLEKDKFEEKFKFCELDGR 253
[25][TOP]
>UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480
RepID=C5FTA8_NANOT
Length = 896
Score = 115 bits (287), Expect = 2e-24
Identities = 68/167 (40%), Positives = 91/167 (54%), Gaps = 10/167 (5%)
Frame = +3
Query: 60 AEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPA 233
AE E + +RWWE +K DG +KWTTLEHNGV FPP YE P + Y G+ + L P
Sbjct: 242 AEEEEAEEEYRWWEDPSKGDGTIKWTTLEHNGVVFPPPYEPLPKDVKMKYAGVPITLHPD 301
Query: 234 AEEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFS 389
AEEVA+ + + L + H V F+ NFF DF+A++ T AK + KCDF
Sbjct: 302 AEEVASHFGTMLNSTHNVENPVFQKNFFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFV 361
Query: 390 RIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I H E K +A+KKA T AE+K A+ + + + DGR
Sbjct: 362 PIFEHHE----KLRAQKKAMTAAEKKAAKAEKDAAEAPYMYCMWDGR 404
[26][TOP]
>UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis
RepID=B9SSQ1_RICCO
Length = 891
Score = 114 bits (286), Expect = 3e-24
Identities = 62/140 (44%), Positives = 83/140 (59%)
Frame = +3
Query: 108 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 287
+ TDG+ KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A TD++
Sbjct: 340 SSTDGQKKWTTLIHNGVIFPPPYKPHGIKILYKGRPVDLAPEQEEVATMFAVMKDTDYMQ 399
Query: 288 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 467
K KF NF+ D+R LL VI LE CDF+ I E EK K KK +T E+K
Sbjct: 400 KPKFLENFWNDWRKLLGRN---HVIQKLEDCDFTPIYEWHEREKEK----KKQMSTEEKK 452
Query: 468 EAREAEAERVRQFTVALVDG 527
+E + + ++ A+VDG
Sbjct: 453 AQKEEKLRQEEKYMWAIVDG 472
[27][TOP]
>UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR
Length = 881
Score = 114 bits (284), Expect = 6e-24
Identities = 74/195 (37%), Positives = 100/195 (51%), Gaps = 19/195 (9%)
Frame = +3
Query: 3 KTEDRT-----LSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNG 155
KTE ++ + G A +P+ E E + +RWWE K DG +KWTTLEHNG
Sbjct: 199 KTEPKSAQSTPVKKGSAKATPVKKEESEEAEEAEEEEYRWWEDPTKGDGTIKWTTLEHNG 258
Query: 156 VYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQ-TDHVLKEKFRSNFFADFR 326
V FPP YE P + Y+G+ ++L P AEEVA F+ S L T HV F+ NFF DF+
Sbjct: 259 VVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNATQHVENPTFQKNFFMDFK 318
Query: 327 ALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 485
+L D+K KV I KCDF I A+ + K+ EKK AE+K + +
Sbjct: 319 DILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLPPAEKKRLKAEK 374
Query: 486 AERVRQFTVALVDGR 530
+ + DGR
Sbjct: 375 DAEEAPYMYCMWDGR 389
[28][TOP]
>UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis
RepID=Q1DXZ1_COCIM
Length = 905
Score = 114 bits (284), Expect = 6e-24
Identities = 66/158 (41%), Positives = 85/158 (53%), Gaps = 10/158 (6%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+
Sbjct: 260 YRWWEEPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFG 319
Query: 261 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 416
S L + H V F+ NFF DF A++ T AK +I +KCDF I + E
Sbjct: 320 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE-- 377
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
K+ EKKA AERK + + + + DGR
Sbjct: 378 --MKREEKKALPAAERKRLKAEKEAAEAPYMYCMWDGR 413
[29][TOP]
>UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01
RepID=C1H484_PARBA
Length = 900
Score = 114 bits (284), Expect = 6e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E G+ +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 247 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 306
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF
Sbjct: 307 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKP 366
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I E + EKKA AE+K + + E + + DGR
Sbjct: 367 IFEFYE----AARLEKKALPAAEKKRLKAEKDELEAPYMYCMWDGR 408
[30][TOP]
>UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357
RepID=B8MY66_ASPFN
Length = 881
Score = 114 bits (284), Expect = 6e-24
Identities = 74/195 (37%), Positives = 100/195 (51%), Gaps = 19/195 (9%)
Frame = +3
Query: 3 KTEDRT-----LSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNG 155
KTE ++ + G A +P+ E E + +RWWE K DG +KWTTLEHNG
Sbjct: 199 KTEPKSAQSTPVKKGSAKATPVKKEESEEAEEAEEEEYRWWEDPTKGDGTIKWTTLEHNG 258
Query: 156 VYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQ-TDHVLKEKFRSNFFADFR 326
V FPP YE P + Y+G+ ++L P AEEVA F+ S L T HV F+ NFF DF+
Sbjct: 259 VVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNATQHVENPTFQKNFFMDFK 318
Query: 327 ALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 485
+L D+K KV I KCDF I A+ + K+ EKK AE+K + +
Sbjct: 319 DILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLPPAEKKRLKAEK 374
Query: 486 AERVRQFTVALVDGR 530
+ + DGR
Sbjct: 375 DAEEAPYMYCMWDGR 389
[31][TOP]
>UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus
NAm1 RepID=A6R590_AJECN
Length = 651
Score = 114 bits (284), Expect = 6e-24
Identities = 66/166 (39%), Positives = 90/166 (54%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E+ + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 256 EAEDAEEEYRWWEDPAKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEA 315
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + ++ AK + S EKCDF
Sbjct: 316 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKP 375
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + E + EKK+ +AE+K + + E + + DGR
Sbjct: 376 IFEYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGR 417
[32][TOP]
>UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
RepID=A9T3W2_PHYPA
Length = 632
Score = 113 bits (283), Expect = 7e-24
Identities = 59/134 (44%), Positives = 82/134 (61%)
Frame = +3
Query: 126 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 305
VKWTTLEHNGV FPP YEPHG ++Y+G + L PA EE+AT +A L+TD+ KE+F
Sbjct: 89 VKWTTLEHNGVIFPPPYEPHGVKMLYDGKPVDLTPAQEEIATMFAVMLETDYAKKERFIK 148
Query: 306 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 485
NF+ D++ L VI E CDF+ I D A++K KK+ +T E+K +E +
Sbjct: 149 NFWDDWKPYLGKN---HVIKKFELCDFTPI----FDWHAREKERKKSMSTEEKKRLKEEK 201
Query: 486 AERVRQFTVALVDG 527
++ A+VDG
Sbjct: 202 LAVEEKYMWAVVDG 215
[33][TOP]
>UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence
n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI
Length = 857
Score = 113 bits (283), Expect = 7e-24
Identities = 59/133 (44%), Positives = 82/133 (61%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A L TD++ KEKF+ N
Sbjct: 315 KWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMQKEKFKEN 374
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
F AD+R +L VI L+ CDF+ I ++EK K KK +T E+K +E +
Sbjct: 375 FMADWRKILGKN---HVIQRLDDCDFTPIYEWHQEEKEK----KKQMSTEEKKTLKEEKL 427
Query: 489 ERVRQFTVALVDG 527
+ ++ A+VDG
Sbjct: 428 KLEEKYMWAIVDG 440
[34][TOP]
>UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE
Length = 2575
Score = 113 bits (283), Expect = 7e-24
Identities = 65/158 (41%), Positives = 89/158 (56%), Gaps = 2/158 (1%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 236
E E + RWWE DG+ KW TL H G FPP YEP G L+Y+G L P A
Sbjct: 1847 EPEEEEEIHRWWEEEELPDGQ-KWRTLTHRGPLFPPAYEPLPKGVHLLYDGKPYLLKPEA 1905
Query: 237 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 416
EE+A FYA L D+V K+ F NF D+RA + + K +T ++KCDFS I +H +
Sbjct: 1906 EEIAGFYAMMLTRDYVHKDIFNENFMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQR 1964
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+KA K E+++ +EAEA+ ++ AL+DGR
Sbjct: 1965 AEARKAASK----EEKEKRKEAEAKLKEEYGFALMDGR 1998
[35][TOP]
>UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735
delta SOWgp RepID=C5P0Y8_COCP7
Length = 905
Score = 113 bits (283), Expect = 7e-24
Identities = 66/158 (41%), Positives = 85/158 (53%), Gaps = 10/158 (6%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+
Sbjct: 260 YRWWEEPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFG 319
Query: 261 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 416
S L + H V F+ NFF DF A++ T AK +I +KCDF I + E
Sbjct: 320 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE-- 377
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
K+ EKKA AERK + + + + DGR
Sbjct: 378 --MKREEKKALPAAERKRLKVEKEAAEAPYMYCMWDGR 413
[36][TOP]
>UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500
RepID=B8MH68_TALSN
Length = 864
Score = 113 bits (283), Expect = 7e-24
Identities = 70/179 (39%), Positives = 93/179 (51%), Gaps = 10/179 (5%)
Frame = +3
Query: 24 SPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPL 197
+P + + AAE E +RWWE K DG +KWTTLEHNGV FPP YE P +
Sbjct: 201 TPVKEESEDVEAAEEEEE---YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKM 257
Query: 198 IYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV----- 359
Y+G+ + L P AEEVA F+ S L + H V F+ NFF DF+A+L T AK
Sbjct: 258 KYDGIPVVLEPEAEEVAGFFGSMLNSTHNVENPTFQKNFFDDFKAILKKTGGAKTQKGEP 317
Query: 360 --ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I KCDF I + + K+ EKKA + AE+K + + + + DGR
Sbjct: 318 IDIKEFSKCDFKPIFEYYD----AKRLEKKAMSAAEKKALKAEKDAAEAPYMYCMWDGR 372
[37][TOP]
>UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL
Length = 886
Score = 113 bits (283), Expect = 7e-24
Identities = 67/166 (40%), Positives = 88/166 (53%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
EGE + +RWW+ K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 233 EGEEEEEEYRWWDDPTKGDGTIKWTTLEHNGVVFPPPYEPLPQDVKMKYDGIPVTLHPEA 292
Query: 237 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L T HV F+ NFF+DF+ +L T AK I KCDF
Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQS 352
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I A+ + K+ EK+ AE+K + + + L DGR
Sbjct: 353 IFAYYD----AKRIEKRNIPPAEKKRLKAEKDAAEAPYMYCLWDGR 394
[38][TOP]
>UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
RepID=Q2HDT9_CHAGB
Length = 907
Score = 113 bits (282), Expect = 9e-24
Identities = 73/183 (39%), Positives = 95/183 (51%), Gaps = 14/183 (7%)
Frame = +3
Query: 24 SPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PH 185
+P G P+ EN +G +RWW+A K D VKWTTLEH+GV FPPEYE P
Sbjct: 233 TPPDKGGKPVKDESKENSEGEDEEEYRWWDAPKKEDDSVKWTTLEHSGVLFPPEYERLPK 292
Query: 186 GFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-- 356
L+Y+G + L AEEVATF+ S L T +V F+ NFFADF+ +L T AK
Sbjct: 293 NVKLLYDGQPVDLHIEAEEVATFFGSMLHSTQNVENPVFQKNFFADFKDILKKTGGAKDK 352
Query: 357 -----VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALV 521
I +K DF++I H + +KA A+ AE+ E +AE F
Sbjct: 353 QGKPVDIKEFKKLDFTKIFDHYKALGDARKARPAAEKKAEKAEKDKAEG----HFMFCKW 408
Query: 522 DGR 530
DGR
Sbjct: 409 DGR 411
[39][TOP]
>UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC
Length = 998
Score = 113 bits (282), Expect = 9e-24
Identities = 69/168 (41%), Positives = 87/168 (51%), Gaps = 10/168 (5%)
Frame = +3
Query: 57 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 230
A EGE + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P
Sbjct: 343 AEEGEEEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHP 402
Query: 231 AAEEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDF 386
AEEVA F+ S L T HV F+ NFF DF+ +L T AK I KCDF
Sbjct: 403 EAEEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDF 462
Query: 387 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + + K+ EKK AE+K + + + L DGR
Sbjct: 463 RPIFDYYD----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGR 506
[40][TOP]
>UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181
RepID=A1D4R5_NEOFI
Length = 886
Score = 113 bits (282), Expect = 9e-24
Identities = 69/166 (41%), Positives = 86/166 (51%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
EGE + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 233 EGEEEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHPEA 292
Query: 237 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L T HV F+ NFF DF+ +L T AK I KCDF
Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRP 352
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + E K+ EKK AE+K + + + L DGR
Sbjct: 353 IFDYYE----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGR 394
[41][TOP]
>UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO
Length = 910
Score = 112 bits (281), Expect = 1e-23
Identities = 58/134 (43%), Positives = 81/134 (60%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KW LEHNGV FPP Y+PHG ++Y+G + L P EEVAT +A L TD++ K +F+ N
Sbjct: 365 KWNKLEHNGVIFPPPYKPHGIKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMNKPRFKEN 424
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
FF D++ +L VI +LE CDFS I + EK K KK TT E+K +E +
Sbjct: 425 FFGDWKKILGKN---HVIQNLENCDFSPIYEWHQSEKEK----KKQMTTEEKKALKEEKL 477
Query: 489 ERVRQFTVALVDGR 530
++ ++ A VDG+
Sbjct: 478 KQEEKYMWAWVDGK 491
[42][TOP]
>UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA
n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC
Length = 884
Score = 112 bits (281), Expect = 1e-23
Identities = 69/179 (38%), Positives = 92/179 (51%), Gaps = 14/179 (7%)
Frame = +3
Query: 36 AAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPL 197
A +P+ E E + +RWWE K DG +KWTTLEHNGV FPP YE P +
Sbjct: 218 AKSTPVKKEESEEAEDADEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKM 277
Query: 198 IYEGMELHLPPAAEEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK------ 356
Y+G+ + L P AEEVA F+ L T HV F+ NFF DFR +L T AK
Sbjct: 278 KYDGIPVTLHPDAEEVAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNK 337
Query: 357 -VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I KCDF I A+ +++ + EKKA AE+K + + + + + DGR
Sbjct: 338 VDIKDFHKCDFQPIFAYYDNQ----RQEKKALPPAEKKRLKAEKDAQEAPYMFCMWDGR 392
[43][TOP]
>UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC
6260 RepID=UPI000151AE34
Length = 754
Score = 112 bits (280), Expect = 2e-23
Identities = 67/179 (37%), Positives = 99/179 (55%), Gaps = 3/179 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +TL A + L E E + ++WWEA + DGE KW +L HNGV FPPEYEP
Sbjct: 92 KETSQTLDAQLATPTDLIKKEKEEEET-YKWWEAQDM-DGEQKWESLHHNGVMFPPEYEP 149
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
+ Y+G + L PAAEEVA F+A+ L+TDH F+ NF+ DF ++ ++ A
Sbjct: 150 LPSHVKMYYDGKPVDLAPAAEEVAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGAN 209
Query: 357 V-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
V + K DF+++ AH E K +KK + E+K +EA+ + + L++GR
Sbjct: 210 VEMKDFTKADFTKMHAHFE----MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGR 264
[44][TOP]
>UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR
Length = 877
Score = 112 bits (280), Expect = 2e-23
Identities = 59/138 (42%), Positives = 84/138 (60%)
Frame = +3
Query: 114 TDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 293
+DG+ KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A TD+V K
Sbjct: 329 SDGQKKWTTLVHNGVIFPPPYKPHGVKILYKGKPIDLTPEQEEVATMFAVMKDTDYVQKP 388
Query: 294 KFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 473
+FR NF+ D+R LL VI L+ CDF+ I + EK K KK +T E+K
Sbjct: 389 QFRQNFWNDWRKLLGKN---HVIQKLDDCDFNPIYEWHQQEKEK----KKQMSTEEKKVL 441
Query: 474 REAEAERVRQFTVALVDG 527
+E + ++ ++ A+V+G
Sbjct: 442 KEEKLKQEEKYMWAIVNG 459
[45][TOP]
>UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18
RepID=C1GKM6_PARBD
Length = 825
Score = 112 bits (280), Expect = 2e-23
Identities = 67/166 (40%), Positives = 86/166 (51%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E G+ +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 252 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 311
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF
Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I E + EKKA E+K + + E + + DGR
Sbjct: 372 IFEFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGR 413
[46][TOP]
>UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03
RepID=C0SEQ3_PARBP
Length = 905
Score = 112 bits (280), Expect = 2e-23
Identities = 67/166 (40%), Positives = 86/166 (51%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E G+ +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 252 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 311
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF
Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I E + EKKA E+K + + E + + DGR
Sbjct: 372 IFEFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGR 413
[47][TOP]
>UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus
RepID=UPI00017968A4
Length = 655
Score = 112 bits (279), Expect = 2e-23
Identities = 68/168 (40%), Positives = 94/168 (55%), Gaps = 3/168 (1%)
Frame = +3
Query: 33 RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYE 206
R A +P G + E G +RWWE DG VKW LEH G YF P YEP G Y+
Sbjct: 77 RDAEAPKGQEKEEAGQ--WRWWEEEKSQDG-VKWKQLEHKGPYFAPSYEPLPDGVHFYYD 133
Query: 207 GMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDF 386
G + L AAEEVATFY L ++ KE F++NFF+D+R + + K+I L+KCDF
Sbjct: 134 GKPVKLSLAAEEVATFYGKMLDHEYTTKEVFQNNFFSDWRKEMT-AEERKIIKHLDKCDF 192
Query: 387 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDG 527
+ I + D+ A +KA + E K+ + EAE+++Q F +DG
Sbjct: 193 TEIHRYFVDKTAARKA-----LSREEKQKLKEEAEKLQQEFGYCTLDG 235
[48][TOP]
>UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii
RepID=A5DLX4_PICGU
Length = 754
Score = 111 bits (278), Expect = 3e-23
Identities = 60/151 (39%), Positives = 89/151 (58%), Gaps = 3/151 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWEA + DGE KW +L HNGV FPPEYEP + Y+G + L PAAEEVA F+A
Sbjct: 119 YKWWEAQDM-DGEQKWESLHHNGVMFPPEYEPLPSHVKMYYDGKPVDLAPAAEEVAGFFA 177
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 437
+ L+TDH F+ NF+ DF ++ ++ A V + K DF+++ AH E K +
Sbjct: 178 AMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE----MLKEQ 233
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK + E+K +EA+ + + L++GR
Sbjct: 234 KKNMSRDEKKALKEAKEKEEEPYKTCLLNGR 264
[49][TOP]
>UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri
RepID=Q00XV7_OSTTA
Length = 783
Score = 111 bits (277), Expect = 4e-23
Identities = 61/147 (41%), Positives = 83/147 (56%), Gaps = 6/147 (4%)
Frame = +3
Query: 108 NKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 269
N+++G VK W TLEHNGV FPP YEPHG PL Y+G ++ L P EE+A F+A
Sbjct: 223 NRSEGYVKKGAVIMWKTLEHNGVVFPPPYEPHGVPLTYDGQDVKLLPHEEEIAGFFAVMK 282
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
TD+ K F NF F+ LA+ A IT KCDF+++ H AK + EKK
Sbjct: 283 DTDYAQKAVFVKNFMDGFKEALANGPHA-FITDFRKCDFTKMYNHF----AKIREEKKQM 337
Query: 450 TTAERKEAREAEAERVRQFTVALVDGR 530
T+ E+K + + + +T A +DGR
Sbjct: 338 TSEEKKRIKAEKDKAEEMYTWATIDGR 364
[50][TOP]
>UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624
RepID=Q0CUT4_ASPTN
Length = 872
Score = 110 bits (276), Expect = 5e-23
Identities = 69/181 (38%), Positives = 94/181 (51%), Gaps = 14/181 (7%)
Frame = +3
Query: 30 GRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGF 191
G A +P+ E + + +RWWE K+DG +KWTTLEHNGV FPP YE P
Sbjct: 204 GSAKATPVKKEESADAEEAEEEEYRWWEDPTKSDGTIKWTTLEHNGVVFPPPYEPLPKNV 263
Query: 192 PLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFADFRALL------ADTKF 350
+ Y+G+ + L P AEEVA F+ S L T H F+ NFF DF+ +L D K
Sbjct: 264 KMKYDGVPVTLHPDAEEVAGFFGSMLNSTQHTENPTFQKNFFMDFKDILKKTGGATDPKG 323
Query: 351 AKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
KV I +KCDF I + E K+ EK+ AE+K + + E+ + + DG
Sbjct: 324 NKVDIKEFKKCDFQPIFDYYE----AKRIEKRNLPAAEKKRLKAEKDEQEAPYMYCMWDG 379
Query: 528 R 530
R
Sbjct: 380 R 380
[51][TOP]
>UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH
Length = 916
Score = 110 bits (276), Expect = 5e-23
Identities = 60/138 (43%), Positives = 85/138 (61%), Gaps = 1/138 (0%)
Frame = +3
Query: 117 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 296
DG+ KWTTL HNGV FPP Y+PHG ++Y+G + L EEVAT +A +TD+ K +
Sbjct: 366 DGQKKWTTLVHNGVIFPPPYKPHGIKILYKGKPVDLTIEQEEVATMFAVMRETDYYTKPQ 425
Query: 297 FRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEA 473
FR NF+ D+R LL VI L+ CDF+ I E HLE+ K +KK +T E+K
Sbjct: 426 FRENFWNDWRRLLGK---KHVIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKAL 477
Query: 474 REAEAERVRQFTVALVDG 527
+E + ++ ++ A+VDG
Sbjct: 478 KEEKMKQEEKYMWAVVDG 495
[52][TOP]
>UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays
RepID=B7ZWU7_MAIZE
Length = 574
Score = 110 bits (275), Expect = 6e-23
Identities = 60/137 (43%), Positives = 80/137 (58%), Gaps = 1/137 (0%)
Frame = +3
Query: 120 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 299
G KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K F
Sbjct: 28 GGKKWTTLEHNGVIFPPPYKPHGVKMLYNGKPIDLTPEQEEVATMFAVMKDTDYAAKPTF 87
Query: 300 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 476
NFF D+R +L +I + E CDF+ I E HL ++K KK TT E+K R
Sbjct: 88 IDNFFTDWRKVLGKN---HIIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLR 139
Query: 477 EAEAERVRQFTVALVDG 527
E + ++ ++ A+VDG
Sbjct: 140 EDKLKQEEKYMWAVVDG 156
[53][TOP]
>UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732
RepID=C5DTC9_ZYGRC
Length = 843
Score = 110 bits (275), Expect = 6e-23
Identities = 70/179 (39%), Positives = 93/179 (51%), Gaps = 5/179 (2%)
Frame = +3
Query: 9 EDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP-- 182
ED T S A A E ++WWE K D VKWTTL+HNGV FPP YEP
Sbjct: 185 EDSTKSEDAEADVDAEAEEN------YKWWEK-EKDDDTVKWTTLKHNGVIFPPTYEPLP 237
Query: 183 HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFA 353
+ Y G + LPP AEEVA F+A+ LQ+DH F+SNFF DF +L + TK
Sbjct: 238 SHIKMYYNGKPVDLPPQAEEVAGFFAALLQSDHAKNTVFQSNFFNDFIEVLNENGGTKNG 297
Query: 354 KVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I S +KCDF+++ E +K ++K + E+K+ R + F +DGR
Sbjct: 298 INIESFDKCDFTKMFEFFE----MQKEQRKQLSPQEKKQLRMEREKFEEPFKYCELDGR 352
[54][TOP]
>UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340
RepID=C5DEP3_LACTC
Length = 756
Score = 110 bits (275), Expect = 6e-23
Identities = 62/154 (40%), Positives = 89/154 (57%), Gaps = 6/154 (3%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
F+WWE N+ D +KWTTL+HNGV FPP YEP L Y+G + LPP AEEVA F+A
Sbjct: 118 FKWWEKENEDDS-IKWTTLKHNGVIFPPPYEPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 176
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 431
+ L++DH F+ NFF DF +L + K I E CDFS++ + + +K
Sbjct: 177 ALLESDHAQNPVFQKNFFNDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQLQK---- 232
Query: 432 AEKKAQTTAERKEAREAEAERVRQ-FTVALVDGR 530
E+K Q +++ K+ + E E+ + F +DGR
Sbjct: 233 -EQKKQLSSQEKKKLKIEKEQFEEPFKFCFLDGR 265
[55][TOP]
>UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO
Length = 732
Score = 110 bits (274), Expect = 8e-23
Identities = 61/163 (37%), Positives = 89/163 (54%), Gaps = 5/163 (3%)
Frame = +3
Query: 57 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 230
+ +GE F+WWE + D VKW TL HNGV FPPEY P L Y G + LP
Sbjct: 83 SVDGEEDSEEFKWWEREEEKDDSVKWVTLRHNGVMFPPEYTPLPSHVRLYYGGKAVELPA 142
Query: 231 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEA 401
AEEVA F+A+ LQ+DH F+ NFF DF ++L A+ I KCDFS++ A
Sbjct: 143 EAEEVAGFFAALLQSDHAQNPVFQKNFFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHA 202
Query: 402 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+++ +++ + K ++ ERK ++ + + V L+ GR
Sbjct: 203 YIQ----QQRVQMKQLSSHERKLLKQEKGQTEGPVQVLLLTGR 241
[56][TOP]
>UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE
Length = 904
Score = 109 bits (273), Expect = 1e-22
Identities = 60/137 (43%), Positives = 79/137 (57%), Gaps = 1/137 (0%)
Frame = +3
Query: 120 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 299
G KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K F
Sbjct: 358 GGKKWTTLEHNGVIFPPPYKPHGVKMLYNGKPVDLTPEQEEVATMFAVMKDTDYAAKPTF 417
Query: 300 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 476
NFF D+R +L +I + E CDF+ I E HL ++K KK TT E+K R
Sbjct: 418 IDNFFTDWRKVLGKN---HIIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLR 469
Query: 477 EAEAERVRQFTVALVDG 527
E ++ ++ A+VDG
Sbjct: 470 EDNLKQEEKYMWAVVDG 486
[57][TOP]
>UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT
Length = 926
Score = 109 bits (273), Expect = 1e-22
Identities = 57/133 (42%), Positives = 79/133 (59%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV FPP Y+PHG ++Y+ L L P EEVAT +A+ L TD++ K +F+ N
Sbjct: 382 KWTTLVHNGVMFPPPYKPHGVKMLYKRQPLTLTPEQEEVATMFAAMLDTDYMNKPRFKEN 441
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
FF+D++ +L I +LE CDF I + EK K KK TT E+K +E
Sbjct: 442 FFSDWKKILGKN---HTIQNLEDCDFGPIYEWHQQEKEK----KKQMTTEEKKALKEERL 494
Query: 489 ERVRQFTVALVDG 527
+ ++ A+VDG
Sbjct: 495 QLEEKYMWAIVDG 507
[58][TOP]
>UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
42720 RepID=C4XZS7_CLAL4
Length = 764
Score = 109 bits (273), Expect = 1e-22
Identities = 59/151 (39%), Positives = 83/151 (54%), Gaps = 3/151 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +W TLEHNGV FPP Y+P L Y+ ++LP AAEEVA F+A
Sbjct: 128 YKWWEDEKFGEGPDRWQTLEHNGVIFPPPYKPLPSYVKLYYDSKPVNLPLAAEEVAGFFA 187
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 437
L+TDH F+ NFF DF +L + V IT +KCDFS++ AH K + E
Sbjct: 188 EMLETDHAKNPVFQKNFFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF----VKVREE 243
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK + AE+ ++ + L++GR
Sbjct: 244 KKNMSKAEKLRLKQEREALEEPYRTCLLNGR 274
[59][TOP]
>UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG
Length = 763
Score = 109 bits (273), Expect = 1e-22
Identities = 58/151 (38%), Positives = 91/151 (60%), Gaps = 3/151 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE N D E+KW +L+HNGV FPPE+ P L Y+ + LP AEEVA F+
Sbjct: 127 YKWWEENNDND-EIKWHSLKHNGVLFPPEHVPLPSHVKLYYDKKPVDLPIQAEEVACFFG 185
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 437
+ L T+H F++NFF+DF+ ++ + A V I S +KCDFS+I H E +K+
Sbjct: 186 AMLNTEHAQNPAFQNNFFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQKSL---- 241
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK+ T A+++E + + + ++ L++GR
Sbjct: 242 KKSLTAAQKREIKSEKDKFEEKYKYCLLNGR 272
[60][TOP]
>UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora
DSM 70294 RepID=A7TJW1_VANPO
Length = 799
Score = 109 bits (273), Expect = 1e-22
Identities = 59/153 (38%), Positives = 85/153 (55%), Gaps = 5/153 (3%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE N +GE++WTTL HNGV FPP Y P L Y G + LPP AEEVA F+A
Sbjct: 161 YKWWE-DNDDNGEIQWTTLRHNGVMFPPPYVSLPSHIKLYYNGQAVDLPPTAEEVAGFFA 219
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK 431
+ L TDH F+ NFF DF+ +L + T + E CDFS++ + E + +
Sbjct: 220 ALLHTDHAKNTVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEIQ----R 275
Query: 432 AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
++K + E+K+ R + E+ F +DGR
Sbjct: 276 EQRKKLSPQEKKQLRLEKEEQEEPFKFCELDGR 308
[61][TOP]
>UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum
bicolor RepID=C5YGY1_SORBI
Length = 921
Score = 109 bits (272), Expect = 1e-22
Identities = 59/134 (44%), Positives = 79/134 (58%), Gaps = 1/134 (0%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K F N
Sbjct: 378 KWTTLEHNGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYAGKPTFIDN 437
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 485
FF D+R +L +I E CDF+ I E HL ++K +KK TT E+K RE +
Sbjct: 438 FFTDWRKILGKN---HIIKKFELCDFTPIYEWHL-----REKEKKKQMTTEEKKALREEK 489
Query: 486 AERVRQFTVALVDG 527
++ ++ A+VDG
Sbjct: 490 LKQEEKYMWAVVDG 503
[62][TOP]
>UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI
Length = 871
Score = 109 bits (272), Expect = 1e-22
Identities = 64/158 (40%), Positives = 84/158 (53%), Gaps = 10/158 (6%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+
Sbjct: 226 YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285
Query: 261 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 416
S L T H F+ NFFADF+ +L T AK I KCDF I + +
Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYD-- 343
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
++ EKKA AE+K + + + + + DGR
Sbjct: 344 --AQRQEKKALPPAEKKRLKAEKDAQEAPYMYCMWDGR 379
[63][TOP]
>UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2
Tax=Emericella nidulans RepID=C8VUK1_EMENI
Length = 871
Score = 109 bits (272), Expect = 1e-22
Identities = 64/158 (40%), Positives = 84/158 (53%), Gaps = 10/158 (6%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+
Sbjct: 226 YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285
Query: 261 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 416
S L T H F+ NFFADF+ +L T AK I KCDF I + +
Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYD-- 343
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
++ EKKA AE+K + + + + + DGR
Sbjct: 344 --AQRQEKKALPPAEKKRLKAEKDAQEAPYMYCMWDGR 379
[64][TOP]
>UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis
RepID=C5GB81_AJEDR
Length = 911
Score = 109 bits (272), Expect = 1e-22
Identities = 65/166 (39%), Positives = 86/166 (51%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
EGE + +RWWE + DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A
Sbjct: 258 EGEEAEEEYRWWEDPAQGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEA 317
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EEVA F+ S L + H V F+ NFF DF A + + AK I S + CDF
Sbjct: 318 EEVAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKP 377
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + E + EKK AE+K + + E + + DGR
Sbjct: 378 IFEYYE----AARLEKKNLPAAEKKRLKAEKDELEAPYMYCMWDGR 419
[65][TOP]
>UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin
54-1255 RepID=B6H1W4_PENCW
Length = 864
Score = 109 bits (272), Expect = 1e-22
Identities = 64/164 (39%), Positives = 92/164 (56%), Gaps = 10/164 (6%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 242
E + +RWWE +K DG +KWTTLEHNGV FPPEYE P + Y+G+ + L P AEE
Sbjct: 212 EEEEEEYRWWEDQSKGDGTIKWTTLEHNGVVFPPEYELLPQNVKMKYDGIPITLAPEAEE 271
Query: 243 VATFYASKLQTDH-VLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 398
VA+F+ + L + H V F+ NFF+DF+ ++ D+K KV I KCDF I
Sbjct: 272 VASFFGTMLNSTHNVENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIF 331
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+ ++ EK+ AE+K A+ + E+ + + DGR
Sbjct: 332 EFYD----AQREEKRHLPPAEKKAAKALKDEQEAPYQYCIWDGR 371
[66][TOP]
>UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii
CBS767 RepID=UPI00003BE191
Length = 789
Score = 108 bits (271), Expect = 2e-22
Identities = 63/164 (38%), Positives = 90/164 (54%), Gaps = 4/164 (2%)
Frame = +3
Query: 48 PLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELH 221
P E E + ++WWEA + DGE KW +LEHNGV FPP+YEP L Y+G +
Sbjct: 141 PSSTREDEEDEEKYKWWEAED-VDGEQKWESLEHNGVIFPPDYEPLPSHVKLYYDGKPVD 199
Query: 222 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIE 398
LP AEEVA F+ + +TDH F+ NFF DF +L D V I + DFS++
Sbjct: 200 LPLEAEEVAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMH 259
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDG 527
AH E + +KK K + K+A +AE ++ + + L++G
Sbjct: 260 AHFEMLRDQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNG 298
[67][TOP]
>UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA
Length = 789
Score = 108 bits (271), Expect = 2e-22
Identities = 63/164 (38%), Positives = 90/164 (54%), Gaps = 4/164 (2%)
Frame = +3
Query: 48 PLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELH 221
P E E + ++WWEA + DGE KW +LEHNGV FPP+YEP L Y+G +
Sbjct: 141 PSSTREDEEDEEKYKWWEAED-VDGEQKWESLEHNGVIFPPDYEPLPSHVKLYYDGKPVD 199
Query: 222 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIE 398
LP AEEVA F+ + +TDH F+ NFF DF +L D V I + DFS++
Sbjct: 200 LPLEAEEVAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMH 259
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDG 527
AH E + +KK K + K+A +AE ++ + + L++G
Sbjct: 260 AHFEMLRDQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNG 298
[68][TOP]
>UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT
Length = 927
Score = 108 bits (270), Expect = 2e-22
Identities = 56/133 (42%), Positives = 79/133 (59%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV FPP Y PHG ++Y+ + L P EEVAT +A L TD++ K +F+ N
Sbjct: 383 KWTTLVHNGVIFPPPYNPHGVKMLYKRQPITLTPEQEEVATMFAVMLDTDYMNKPRFKEN 442
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
FF+D++ +L I +LE CDF I + EK K KK TT E+K +E +
Sbjct: 443 FFSDWKKMLGKN---HTIQNLEDCDFGPIYEWHQQEKEK----KKQMTTEEKKALKEDKL 495
Query: 489 ERVRQFTVALVDG 527
++ ++ A+VDG
Sbjct: 496 QQEEKYMWAIVDG 508
[69][TOP]
>UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina
RepID=B2AY06_PODAN
Length = 904
Score = 108 bits (270), Expect = 2e-22
Identities = 65/158 (41%), Positives = 86/158 (54%), Gaps = 10/158 (6%)
Frame = +3
Query: 45 SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMEL 218
S +A E + +RWW+A K D +KWTTLEHNGV FPP YE P LIY+G +
Sbjct: 241 SVANSAADEEEEEEYRWWDAPKKEDDSIKWTTLEHNGVLFPPAYEPLPKDVKLIYDGTPV 300
Query: 219 HLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLE 374
+L AEEVATF+ + L T +V F+ NFF DFR +L +T AK I
Sbjct: 301 NLHVDAEEVATFFGAMLHSTQNVENPTFQKNFFKDFRDVLKETGGAKDQNGKPVDIKEFA 360
Query: 375 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
K DF++I + + KKA A+ AE+ E + EA
Sbjct: 361 KLDFTKIFEYYKGLSEAKKARPAAEKKAEKAEKDKFEA 398
[70][TOP]
>UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea
RepID=A4R0K7_MAGGR
Length = 906
Score = 108 bits (270), Expect = 2e-22
Identities = 66/151 (43%), Positives = 79/151 (52%), Gaps = 10/151 (6%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 242
E + +RWW+A K D +KW TLEHNGV FPP+YE P L Y G+ L L P AEE
Sbjct: 250 EEEEEEYRWWDAPKKEDDSIKWNTLEHNGVLFPPDYEPLPKNVKLYYNGIPLQLHPEAEE 309
Query: 243 VATFYASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 398
VATF+ S L T +V F NFF F+ L T AK I EK DF I
Sbjct: 310 VATFFGSMLHSTQNVENPTFIKNFFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIF 369
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAE 491
H + + KKA K + AE KEAR+ E
Sbjct: 370 QHFQAQSEAKKARSKEEKKAE-KEARDKMEE 399
[71][TOP]
>UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis
RepID=UPI000186E5D8
Length = 961
Score = 108 bits (269), Expect = 3e-22
Identities = 61/163 (37%), Positives = 87/163 (53%), Gaps = 2/163 (1%)
Frame = +3
Query: 45 SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMEL 218
SP + E ++WWE + DG+ KW LEH G F P YE P Y+G E+
Sbjct: 393 SPKKVKKEEEQQDVWKWWEEEKREDGK-KWKFLEHKGPLFAPLYERLPKSVKFFYDGKEI 451
Query: 219 HLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE 398
L AEEVATFYA L D+ KEKF +NFF D+R ++ D K KVIT L KC+F +
Sbjct: 452 SLSEEAEEVATFYAKMLTHDYTTKEKFNTNFFNDWRKVMTD-KERKVITDLSKCNFKPMA 510
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+ ++ K E+KA + E+K ++ +++ +DG
Sbjct: 511 LYFQE----KSEERKAMSKEEKKVIKDQNDAIQKEYGFCTIDG 549
[72][TOP]
>UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa
RepID=B9I1A0_POPTR
Length = 860
Score = 108 bits (269), Expect = 3e-22
Identities = 59/139 (42%), Positives = 83/139 (59%), Gaps = 1/139 (0%)
Frame = +3
Query: 114 TDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 293
+DG+ KW TL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A T++V K
Sbjct: 312 SDGQKKWKTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMKDTEYVQKP 371
Query: 294 KFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKE 470
+F NF+ D+R LL VI LE CDF+ I E H K+K +KK +T E+K
Sbjct: 372 QFLQNFWNDWRTLLGKN---HVIQKLEACDFNPIYEWH-----QKEKEKKKQMSTEEKKA 423
Query: 471 AREAEAERVRQFTVALVDG 527
RE + ++ + A+V+G
Sbjct: 424 VREEKLKQEEMYMWAIVNG 442
[73][TOP]
>UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis
RepID=A4HB62_LEIBR
Length = 637
Score = 108 bits (269), Expect = 3e-22
Identities = 66/179 (36%), Positives = 86/179 (48%), Gaps = 3/179 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPE 173
K EDR ++ R + EN + WWE N GE +W TL HNGV FPPE
Sbjct: 2 KVEDRKMAVKREQSH--SNEDEENNEEDLNWWEQENLRIAMKGERRWETLSHNGVLFPPE 59
Query: 174 YEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFA 353
YEPHG + Y+G E + P EEVAT +A + D+ E FR NFF +R +L K
Sbjct: 60 YEPHGISIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEAFRRNFFESWREIL--DKRQ 117
Query: 354 KVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I LE CDF I E+ K K +T E+K +E + + + DGR
Sbjct: 118 HPIRRLELCDFEPIYQWYLAEREK----KLNRTKEEKKSIKEKQDMDAEPYRYCMWDGR 172
[74][TOP]
>UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
RepID=C7YQG7_NECH7
Length = 919
Score = 108 bits (269), Expect = 3e-22
Identities = 68/170 (40%), Positives = 90/170 (52%), Gaps = 12/170 (7%)
Frame = +3
Query: 57 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 230
A E + F WW K D +KW TLEHNGV FPPEYE P LIY+G ++L P
Sbjct: 254 AKESGEEEEEFAWWLEPKKEDDSIKWNTLEHNGVLFPPEYEPMPKHIKLIYDGKPVNLAP 313
Query: 231 AAEEVATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCD 383
EEVATF+ + + + H+ FR NFF DF+ + D KV I SL+KCD
Sbjct: 314 EVEEVATFWVAMMTPASSHHMENPVFRKNFFEDFQEYCKKYGVTDADGKKVQIKSLDKCD 373
Query: 384 FSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVR-QFTVALVDGR 530
F+++ + AK + K T E KEA +A+ E + FT + DGR
Sbjct: 374 FTKLADYW---LAKAEQNKTKNMTKEEKEAAKAKKEALEAPFTHCMWDGR 420
[75][TOP]
>UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1
RepID=UPI000023DEFB
Length = 910
Score = 107 bits (268), Expect = 4e-22
Identities = 64/172 (37%), Positives = 90/172 (52%), Gaps = 15/172 (8%)
Frame = +3
Query: 60 AEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPA 233
A +G+ F WW A K D +KWTTLEHNGV FPP+YE P ++Y+G + L P
Sbjct: 246 ASESDGEEEFEWWNAPKKEDDSIKWTTLEHNGVLFPPDYEPLPKNVKMLYDGQPVTLAPE 305
Query: 234 AEEVATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDF 386
EEVATF+ + + H+ FR NFF DF+ + D + KV I SL+KC+F
Sbjct: 306 VEEVATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDVQGKKVAIKSLDKCNF 365
Query: 387 SRIEAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+I + +E K K +++ + +K+A EA FT DGR
Sbjct: 366 DKINDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEA------PFTHCTWDGR 411
[76][TOP]
>UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum
RepID=Q9Y180_LEIIN
Length = 635
Score = 107 bits (268), Expect = 4e-22
Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
Frame = +3
Query: 69 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E
Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 407
EVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL
Sbjct: 82 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 139
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 500
E + ++ K EKKA KE ++AEAE R
Sbjct: 140 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 165
[77][TOP]
>UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani
RepID=Q9NJG8_LEIDO
Length = 949
Score = 107 bits (268), Expect = 4e-22
Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
Frame = +3
Query: 69 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E
Sbjct: 337 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 396
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 407
EVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL
Sbjct: 397 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 454
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 500
E + ++ K EKKA KE ++AEAE R
Sbjct: 455 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 480
[78][TOP]
>UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN
Length = 635
Score = 107 bits (268), Expect = 4e-22
Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
Frame = +3
Query: 69 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E
Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 407
EVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL
Sbjct: 82 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 139
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 500
E + ++ K EKKA KE ++AEAE R
Sbjct: 140 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 165
[79][TOP]
>UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma
cruzi RepID=Q4DTW1_TRYCR
Length = 664
Score = 107 bits (268), Expect = 4e-22
Identities = 62/138 (44%), Positives = 77/138 (55%), Gaps = 4/138 (2%)
Frame = +3
Query: 93 WWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS 263
WWE N T G+ +W TL HNGV FPPEY+PHG P+ YEG E L P EEVAT +A
Sbjct: 33 WWEQENVQFTTKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAV 92
Query: 264 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEK 440
+ D+ E FR NFF+ +R +L K I LE CDF I + HL ++ EK
Sbjct: 93 MREHDYYRNEIFRRNFFSSWREIL--DKRQHPIRRLELCDFEPIYQWHL------REREK 144
Query: 441 KAQTTAERKEAREAEAER 494
K T E K+ EAE+
Sbjct: 145 KLSRTKEEKKQLRLEAEK 162
[80][TOP]
>UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704
RepID=C4JVV4_UNCRE
Length = 889
Score = 107 bits (268), Expect = 4e-22
Identities = 65/158 (41%), Positives = 83/158 (52%), Gaps = 10/158 (6%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L AEEVA F+
Sbjct: 262 YRWWEDPAKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPITLSLEAEEVAGFFG 321
Query: 261 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 416
S L + H V F+ NFF DF A++ T AK I +KCDF I + E
Sbjct: 322 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIFEYYE-- 379
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
K+ EKKA AERK + + + + DGR
Sbjct: 380 --MKRLEKKALPAAERKRLKAEKDAAEAPYMYCMWDGR 415
[81][TOP]
>UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC
Length = 852
Score = 107 bits (267), Expect = 5e-22
Identities = 56/133 (42%), Positives = 79/133 (59%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT YA L TD++ K +F+ N
Sbjct: 334 KWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMSKLQFKEN 393
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
F D+R +L VI +L+ CDF+ I EK K KK +T ++ RE +
Sbjct: 394 FMNDWRKILGKN---HVIQNLDDCDFTPIYERPSSEKEK----KKQMSTKRKRPLREEKL 446
Query: 489 ERVRQFTVALVDG 527
++ ++ A+VDG
Sbjct: 447 KQEEKYMWAIVDG 459
[82][TOP]
>UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major
RepID=Q4Q2K0_LEIMA
Length = 634
Score = 107 bits (267), Expect = 5e-22
Identities = 62/147 (42%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Frame = +3
Query: 69 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E
Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 419
EVAT +A + D+ E FR NFF +R +L K I LE CDF I ++
Sbjct: 82 EVATMFAVMKEHDYYRMEVFRRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQR 139
Query: 420 AKKKAEKKAQTTAERKEAREAEAERVR 500
KK + K + A KE ++AEAE R
Sbjct: 140 EKKLSRTKEEKKA-IKEKQDAEAEPYR 165
[83][TOP]
>UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
topoisomerase I n=1 Tax=Candida glabrata
RepID=Q6FVE9_CANGA
Length = 717
Score = 107 bits (267), Expect = 5e-22
Identities = 63/153 (41%), Positives = 85/153 (55%), Gaps = 5/153 (3%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +K D +KWTTLEHNGV FPP YE P L YEG + LP AEEVA F+A
Sbjct: 79 YKWWEEQDKDD-TIKWTTLEHNGVLFPPPYEALPSHVKLYYEGNPVDLPLEAEEVAGFFA 137
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK 431
L+T H F+ NFF DF+ +L D T+ I S ++ DFS + D + K
Sbjct: 138 HLLETPHAQNPVFQKNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHDYFVQLK 193
Query: 432 AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
EKK+ T ++KE R + ++ +DGR
Sbjct: 194 EEKKSMTAMQKKEIRLEREKFEEKYKFCELDGR 226
[84][TOP]
>UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA
Length = 785
Score = 107 bits (267), Expect = 5e-22
Identities = 60/153 (39%), Positives = 86/153 (56%), Gaps = 5/153 (3%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
F+WWE G+K D +KWTTL+HNGV FP YE P L Y G + LPP AEEVA F+A
Sbjct: 146 FKWWENGDKEDDTIKWTTLKHNGVIFPSTYEPLPAHVKLYYNGKPVDLPPQAEEVAGFFA 205
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKK 431
+ L++DHV F+ NF DF +L + A+ I K DF++I + + +K
Sbjct: 206 AILESDHVKIPTFQKNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQ----VQK 261
Query: 432 AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+KK + E+K+ R + E + + +DGR
Sbjct: 262 EQKKQLSPQEKKQLRLEKEELEKPYKFCEIDGR 294
[85][TOP]
>UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera
RepID=UPI0000DB758E
Length = 973
Score = 107 bits (266), Expect = 7e-22
Identities = 57/149 (38%), Positives = 82/149 (55%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE K DG KWT LEH G F P YEP Y G E+ L EEVATFYA
Sbjct: 429 WKWWEEEKKNDG-TKWTFLEHKGPVFAPPYEPLPPDVNFYYNGKEMKLSQDTEEVATFYA 487
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ K F SNFF D+R ++ +++ K++ L KC+F I A+ +K E+
Sbjct: 488 RMLDHDYTTKPAFNSNFFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----IQKSEER 542
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
KA T E+++ +E E +++ ++DG
Sbjct: 543 KAMTKEEKQKIKEKNEEIQKEYGYCIIDG 571
[86][TOP]
>UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio
RepID=Q6T721_DANRE
Length = 600
Score = 107 bits (266), Expect = 7e-22
Identities = 60/147 (40%), Positives = 84/147 (57%), Gaps = 3/147 (2%)
Frame = +3
Query: 96 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 269
WE G D VKW++LEH G YF P+YEP Y+G ++ L P EE+ATFYA L
Sbjct: 42 WEEGKSCDA-VKWSSLEHKGPYFAPDYEPLPANICFYYDGQQVKLSPLTEEIATFYAKML 100
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
++ KE F+ NFF D+R + + K+IT+L KCDF+ I + + KAE+K
Sbjct: 101 DHEYTTKEVFQKNFFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE-----KAEEKKN 154
Query: 450 TTAERKEAREAEAER-VRQFTVALVDG 527
T E K+ + EA R + +F L+DG
Sbjct: 155 MTKEEKQVLKDEAARLMEEFGYCLLDG 181
[87][TOP]
>UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR
Length = 664
Score = 107 bits (266), Expect = 7e-22
Identities = 61/138 (44%), Positives = 77/138 (55%), Gaps = 4/138 (2%)
Frame = +3
Query: 93 WWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS 263
WWE N T G+ +W TL HNGV FPPEY+PHG P+ YEG E L P EEVAT +A
Sbjct: 33 WWELENVQFSTKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAV 92
Query: 264 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEK 440
+ D+ E FR NFF+ +R +L + I LE CDF I + HL ++ EK
Sbjct: 93 MREHDYYRNEIFRRNFFSSWREIL--DRRQHPIRRLELCDFEPIYQWHL------REREK 144
Query: 441 KAQTTAERKEAREAEAER 494
K T E K+ EAE+
Sbjct: 145 KLSRTKEEKKQLRLEAEK 162
[88][TOP]
>UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis
RepID=B7Q9Y0_IXOSC
Length = 499
Score = 107 bits (266), Expect = 7e-22
Identities = 65/177 (36%), Positives = 95/177 (53%), Gaps = 3/177 (1%)
Frame = +3
Query: 6 TEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP- 182
TE +T S A+ G A+ E ++WWE DG+ KW TLEH G F P YEP
Sbjct: 190 TEVKTESEPTASKKKKGRAKKEEEVEVWKWWEEEKHDDGK-KWRTLEHKGPVFAPPYEPL 248
Query: 183 -HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV 359
Y+ + L PAAEEVA FY L D+ KE F NFF D+R + K A++
Sbjct: 249 PDNVRFFYDNKVVKLSPAAEEVAGFYGRMLDHDYTSKEAFNKNFFKDWRKTMT-PKEAEL 307
Query: 360 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDG 527
IT L KC+F I+ + K+K+E++ + E K+A +A+ E+ + ++ ++DG
Sbjct: 308 ITDLSKCNFKEIDVYY-----KQKSEERKAMSKEEKQAIKAQNEKLLEEYGFCIIDG 359
[89][TOP]
>UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
RepID=UPI000198447D
Length = 883
Score = 106 bits (265), Expect = 9e-22
Identities = 60/140 (42%), Positives = 79/140 (56%)
Frame = +3
Query: 108 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 287
N +G+ KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+
Sbjct: 334 NSGEGQ-KWTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYAT 392
Query: 288 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 467
K +F NF D+R L VI E CDF+ I E EK K KK TT E+K
Sbjct: 393 KPRFIENFMNDWRVRLGKN---HVIKKFELCDFTPIYEWHEKEKEK----KKQMTTEEKK 445
Query: 468 EAREAEAERVRQFTVALVDG 527
+E + ++ ++ A+VDG
Sbjct: 446 ALKEEKLKQEDKYMWAVVDG 465
[90][TOP]
>UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia
vitripennis RepID=UPI00015B4D8F
Length = 1019
Score = 106 bits (265), Expect = 9e-22
Identities = 60/163 (36%), Positives = 87/163 (53%), Gaps = 2/163 (1%)
Frame = +3
Query: 45 SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMEL 218
SP + E ++WWE K DG KW LEH G F PEYEP Y G E+
Sbjct: 445 SPKKKKKEEEEPEVWKWWEEEKKNDG-TKWHFLEHKGPVFAPEYEPLPPSVKFYYNGKEM 503
Query: 219 HLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE 398
L EEVATFYA L+ D+ K+ F NFF D+R ++ +++ AK IT L+KC+F+ +
Sbjct: 504 KLTQDTEEVATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAK-ITDLKKCNFTEMH 562
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+ K E+KA + E+K +E E +++ + +DG
Sbjct: 563 KYF----IMKSEERKAMSKEEKKAIKEKNDEIQKEYGICTIDG 601
[91][TOP]
>UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1
Tax=Vitis vinifera RepID=A7PX10_VITVI
Length = 789
Score = 106 bits (265), Expect = 9e-22
Identities = 60/140 (42%), Positives = 79/140 (56%)
Frame = +3
Query: 108 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 287
N +G+ KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+
Sbjct: 240 NSGEGQ-KWTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYAT 298
Query: 288 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 467
K +F NF D+R L VI E CDF+ I E EK K KK TT E+K
Sbjct: 299 KPRFIENFMNDWRVRLGKN---HVIKKFELCDFTPIYEWHEKEKEK----KKQMTTEEKK 351
Query: 468 EAREAEAERVRQFTVALVDG 527
+E + ++ ++ A+VDG
Sbjct: 352 ALKEEKLKQEDKYMWAVVDG 371
[92][TOP]
>UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC
Length = 894
Score = 106 bits (264), Expect = 1e-21
Identities = 56/133 (42%), Positives = 78/133 (58%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KW TL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A L TD++ K KF+ N
Sbjct: 351 KWNTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKSKFKEN 410
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
F D+R +L VI +LE CDF+ I + EK K KK T E+K +E
Sbjct: 411 FMDDWRKILGKN---HVIQNLEDCDFTPIYEWHQREKEK----KKKMTAEEKKVLKEERL 463
Query: 489 ERVRQFTVALVDG 527
++ ++ A+V+G
Sbjct: 464 KQEEKYMWAIVNG 476
[93][TOP]
>UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii
RepID=A8IDM1_CHLRE
Length = 586
Score = 106 bits (264), Expect = 1e-21
Identities = 58/145 (40%), Positives = 85/145 (58%), Gaps = 1/145 (0%)
Frame = +3
Query: 99 EAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTD 278
E G+ G+V W TL+H GV FPPEYEPHG +Y+G + L P EEVAT +A +TD
Sbjct: 20 EPGSSKSGQVMWKTLKHAGVLFPPEYEPHGVKPLYDGKPVDLTPDQEEVATMFAVMKETD 79
Query: 279 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTT 455
++ K+ F NF+ F+ +L VI L+KCDF+ I + H+ +AKK K+
Sbjct: 80 YMNKKVFLDNFWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQREAKKGISKE---- 132
Query: 456 AERKEAREAEAERVRQFTVALVDGR 530
E+ ++ + E+ ++ VA VDGR
Sbjct: 133 -EKDRIKKEKDEKEAKYKVAYVDGR 156
[94][TOP]
>UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei
RepID=Q581U8_9TRYP
Length = 661
Score = 106 bits (264), Expect = 1e-21
Identities = 61/163 (37%), Positives = 81/163 (49%), Gaps = 3/163 (1%)
Frame = +3
Query: 51 LGAAEGENGDGGFRWWEAGNKTD---GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELH 221
L EG DG WW G T GE +W TL HNGV FPP Y PHG P++Y +
Sbjct: 44 LANEEGGGNDGETEWWTQGTLTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFE 103
Query: 222 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA 401
+ P EEVAT +A + D+ E FR NFF +R +L K I LE CDFS I
Sbjct: 104 MTPEEEEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYE 161
Query: 402 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+ E K +K++T E+KE + E + + +G+
Sbjct: 162 WHQREVEK----RKSRTREEKKELKRIADEEAEPYKWCIWNGK 200
[95][TOP]
>UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma
brucei RepID=C9ZLY6_TRYBG
Length = 696
Score = 106 bits (264), Expect = 1e-21
Identities = 61/163 (37%), Positives = 81/163 (49%), Gaps = 3/163 (1%)
Frame = +3
Query: 51 LGAAEGENGDGGFRWWEAGNKTD---GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELH 221
L EG DG WW G T GE +W TL HNGV FPP Y PHG P++Y +
Sbjct: 79 LANEEGGGNDGEAEWWTQGTLTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFE 138
Query: 222 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA 401
+ P EEVAT +A + D+ E FR NFF +R +L K I LE CDFS I
Sbjct: 139 MTPEEEEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYE 196
Query: 402 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+ E K +K++T E+KE + E + + +G+
Sbjct: 197 WHQREVEK----RKSRTREEKKELKRIADEEAEPYKWCIWNGK 235
[96][TOP]
>UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66
RepID=B6ABX7_9CRYT
Length = 660
Score = 106 bits (264), Expect = 1e-21
Identities = 54/145 (37%), Positives = 81/145 (55%)
Frame = +3
Query: 90 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 269
+WWE K + ++W LEHNGV F P Y+ H PLIY+G E+ LP +EE+AT++A L
Sbjct: 39 KWWERPAKDESSIQWDYLEHNGVMFAPPYQAHKVPLIYDGKEIELPNESEEIATYWAQIL 98
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
T+ KE+F N F + + + +KCDFS I+ H ++EK +KK K Q
Sbjct: 99 DTEWSSKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEEKERKKNMNKEQ 158
Query: 450 TTAERKEAREAEAERVRQFTVALVD 524
+++ E+E+ + ALVD
Sbjct: 159 KEQQKRIKNESES----PYIYALVD 179
[97][TOP]
>UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU
Length = 909
Score = 106 bits (264), Expect = 1e-21
Identities = 63/169 (37%), Positives = 89/169 (52%), Gaps = 15/169 (8%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 242
E+ + F WW A K D +KWTTLEHNGV FPP+YE P ++Y+G + L P EE
Sbjct: 248 ESDEEEFEWWNAPKKEDDSIKWTTLEHNGVLFPPDYEPLPKNVKMLYDGQPVTLAPEVEE 307
Query: 243 VATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 395
VATF+ + + H+ FR NFF DF+ + D + KV I SL+KC+F +I
Sbjct: 308 VATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKI 367
Query: 396 EAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+ +E K K +++ + +K+A EA FT DGR
Sbjct: 368 NDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEA------PFTHCTWDGR 410
[98][TOP]
>UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio
rerio RepID=UPI0001760D92
Length = 748
Score = 105 bits (263), Expect = 2e-21
Identities = 59/141 (41%), Positives = 81/141 (57%), Gaps = 2/141 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG KW LEH G FPP YEP Y+G + L PAAEEVATFYA
Sbjct: 186 WKWWEEERYTDGS-KWRFLEHKGPVFPPPYEPLPGHIKFYYDGNAMKLSPAAEEVATFYA 244
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L+ ++ E FR NFF D+R + + +K IT L+KCDF+++ E K ++E
Sbjct: 245 KMLEHEYTTNEIFRKNFFKDWRKEMTSEEKSK-ITELKKCDFTQMH-----EYFKAQSEA 298
Query: 441 KAQTTAERKEAREAEAERVRQ 503
+ Q + E K+ + E ER+ Q
Sbjct: 299 RKQMSKEEKQKNKEENERILQ 319
[99][TOP]
>UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI
Length = 871
Score = 105 bits (263), Expect = 2e-21
Identities = 62/158 (39%), Positives = 83/158 (52%), Gaps = 10/158 (6%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+
Sbjct: 226 YKWWEGPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285
Query: 261 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 416
S L T H F+ NFFADF+ +L T AK I KCD I + +
Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIFQYYD-- 343
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
++ EKKA AE+K + + + + + DGR
Sbjct: 344 --AQRQEKKALPPAEKKRLKAEKDAQEAPYMYCMWDGR 379
[100][TOP]
>UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra
magnipapillata RepID=UPI000192545C
Length = 726
Score = 105 bits (262), Expect = 2e-21
Identities = 61/150 (40%), Positives = 82/150 (54%), Gaps = 3/150 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
+RWW+ DG +KW TL H G YFPPEYEP Y+G + L AEEVATFYA
Sbjct: 152 WRWWDEDPHQDG-IKWKTLSHEGPYFPPEYEPMPKNVKFYYDGKPMQLSLEAEEVATFYA 210
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+V K+ F NFF D+R + + +I SL+KCDF + A+ K AE+
Sbjct: 211 KMLDHDYVKKDIFNENFFEDWRKEMT-AEERNIIKSLDKCDFKEMHAYF-----MKCAEE 264
Query: 441 KAQTTAERKEA-REAEAERVRQFTVALVDG 527
K T E K+A +EA + ++ +DG
Sbjct: 265 KRNMTKEEKQAIKEANLKIAEKYGFCEMDG 294
[101][TOP]
>UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group
RepID=Q84ZL5_ORYSJ
Length = 916
Score = 105 bits (262), Expect = 2e-21
Identities = 57/137 (41%), Positives = 80/137 (58%), Gaps = 1/137 (0%)
Frame = +3
Query: 120 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 299
G KWTTL H+GV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K+ F
Sbjct: 370 GGQKWTTLVHSGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTF 429
Query: 300 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 476
NFF D+R +L VI E CDF+ I E HL ++K +KK T+ E+K +
Sbjct: 430 IDNFFTDWRKILGKN---HVIKKFELCDFTPIYEWHL-----REKEKKKQMTSEEKKALK 481
Query: 477 EAEAERVRQFTVALVDG 527
E + ++ ++ A+VDG
Sbjct: 482 EEKLKQEEKYMWAIVDG 498
[102][TOP]
>UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT
Length = 926
Score = 105 bits (262), Expect = 2e-21
Identities = 54/133 (40%), Positives = 78/133 (58%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV F P Y+PHG ++Y+ L L P EEVAT +A L TD++ K +F+ N
Sbjct: 382 KWTTLVHNGVMFLPPYKPHGVKMLYKXQPLTLTPEQEEVATMFAVMLDTDYMTKPRFKEN 441
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
FF+D++ +L + +LE CDF I + EK K +K TT E+K +E
Sbjct: 442 FFSDWKKMLGKN---HTVQNLEDCDFGPIYEWHQQEKEK----RKQMTTEEKKALKEERL 494
Query: 489 ERVRQFTVALVDG 527
++ ++ A+VDG
Sbjct: 495 QQEEKYMWAIVDG 507
[103][TOP]
>UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group
RepID=A2YRB7_ORYSI
Length = 916
Score = 105 bits (262), Expect = 2e-21
Identities = 57/137 (41%), Positives = 80/137 (58%), Gaps = 1/137 (0%)
Frame = +3
Query: 120 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 299
G KWTTL H+GV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K+ F
Sbjct: 370 GGQKWTTLVHSGVIFPPPYKPHGVKILYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTF 429
Query: 300 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 476
NFF D+R +L VI E CDF+ I E HL ++K +KK T+ E+K +
Sbjct: 430 IDNFFTDWRKILGKN---HVIKKFELCDFTPIYEWHL-----REKEKKKQMTSEEKKALK 481
Query: 477 EAEAERVRQFTVALVDG 527
E + ++ ++ A+VDG
Sbjct: 482 EEKLKQEEKYMWAIVDG 498
[104][TOP]
>UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens
RepID=TOP1M_HUMAN
Length = 601
Score = 105 bits (262), Expect = 2e-21
Identities = 66/161 (40%), Positives = 88/161 (54%), Gaps = 3/161 (1%)
Frame = +3
Query: 54 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLP 227
G+ + G G WE DG VKW LEH G YF P YEP G YEG + L
Sbjct: 30 GSRRTQKGSGAR--WEKEKHEDG-VKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLS 86
Query: 228 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 407
AAEEVATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I +
Sbjct: 87 VAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYF 145
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDG 527
D+ A +K + E K+ + EAE+++Q F ++DG
Sbjct: 146 VDKAAARKV-----LSREEKQKLKEEAEKLQQEFGYCILDG 181
[105][TOP]
>UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes
RepID=TOP1M_PANTR
Length = 601
Score = 105 bits (261), Expect = 3e-21
Identities = 66/161 (40%), Positives = 88/161 (54%), Gaps = 3/161 (1%)
Frame = +3
Query: 54 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLP 227
G+ + G G WE DG VKW LEH G YF P YEP G YEG + L
Sbjct: 30 GSRRTQKGSGAR--WEKEKHEDG-VKWRQLEHKGPYFAPPYEPLPDGVRFFYEGKPVRLS 86
Query: 228 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 407
AAEEVATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I +
Sbjct: 87 VAAEEVATFYGRMLGHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYF 145
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDG 527
D+ A +K + E K+ + EAE++ R+F ++DG
Sbjct: 146 VDKAAARKV-----LSREEKQKLKEEAEKLQREFGYCILDG 181
[106][TOP]
>UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
RepID=B5Y3I3_PHATR
Length = 594
Score = 104 bits (259), Expect = 4e-21
Identities = 59/152 (38%), Positives = 84/152 (55%), Gaps = 5/152 (3%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS- 263
F WW A +G +W T+EH+GV FP YEPHG ++Y+G + L P EE ATF+A+
Sbjct: 4 FLWWNAPELPEG-CQWRTMEHSGVSFPETYEPHGVKMMYDGQPVELTPIQEEAATFFAAM 62
Query: 264 KLQTDHVLKEK----FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK 431
+ H+ K F NFFADFR +L ++ +KCDF I HL ++ K
Sbjct: 63 DPEGMHLGNPKTGKIFIKNFFADFREILGK---KHIVKEFKKCDFEPIRKHLNEQ----K 115
Query: 432 AEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+KA T ERK +E ++ + QF ++VDG
Sbjct: 116 IIRKAITDEERKANKEDRSQTLHQFGFSIVDG 147
[107][TOP]
>UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major
RepID=Q7YXA0_LEIMA
Length = 200
Score = 104 bits (259), Expect = 4e-21
Identities = 61/147 (41%), Positives = 77/147 (52%), Gaps = 3/147 (2%)
Frame = +3
Query: 69 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E
Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 419
EVAT +A + D+ E F NFF +R +L K I LE CDF I ++
Sbjct: 82 EVATMFAVMKEHDYYRMEVFWRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQR 139
Query: 420 AKKKAEKKAQTTAERKEAREAEAERVR 500
KK + K + A KE ++AEAE R
Sbjct: 140 EKKLSRTKEEKEA-IKEKQDAEAEPYR 165
[108][TOP]
>UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO
Length = 1043
Score = 104 bits (259), Expect = 4e-21
Identities = 57/150 (38%), Positives = 81/150 (54%), Gaps = 3/150 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE + DG VKWTTLEH G F P YE P Y+G + L EE ATFYA
Sbjct: 483 WRWWEEEKREDG-VKWTTLEHKGPVFAPPYERVPRNVRFFYDGKPMELSEETEEAATFYA 541
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ K+ F +NFF DFR + K ++I KC+F + + + E K+KA
Sbjct: 542 KMLNHDYCTKDVFNNNFFKDFRKTMT-PKEKEIIKDFRKCNFQEMFEYFQAESEKRKA-- 598
Query: 441 KAQTTAERKEAREAEAER-VRQFTVALVDG 527
T E K A++ E+E ++++ ++DG
Sbjct: 599 ---ATKEEKLAKKVESEALIKEYGFCMIDG 625
[109][TOP]
>UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA
Length = 763
Score = 104 bits (259), Expect = 4e-21
Identities = 63/187 (33%), Positives = 96/187 (51%), Gaps = 11/187 (5%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDG--------GFRWWEAGNKTDGEVKWTTLEHNGV 158
KTE + ++ L + E +N + ++WWE + DG +KW TLEHNGV
Sbjct: 92 KTEKKLKKKHKSQEKELNSEELKNEESLRSKEEEEDYKWWEQ-QQGDGTIKWKTLEHNGV 150
Query: 159 YFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE-KFRSNFFADFRA 329
FPP YE P + Y+G + LPP AEEVA F+ + L ++ +K F+ NFF DF+
Sbjct: 151 LFPPPYEPLPSYVKMKYKGEPISLPPEAEEVAGFFGAILSSEQYVKNPTFQKNFFHDFQE 210
Query: 330 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 509
T + E CDF+ + + E KKK EKK ++ E+K+ +E + ++
Sbjct: 211 TCKKTNAPVIPEKFEYCDFTPMFEYFE----KKKEEKKNKSKEEKKKIKEEKDALEEKYK 266
Query: 510 VALVDGR 530
+DGR
Sbjct: 267 YCFLDGR 273
[110][TOP]
>UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1
Tax=Tribolium castaneum RepID=UPI00017582B6
Length = 936
Score = 103 bits (258), Expect = 6e-21
Identities = 58/150 (38%), Positives = 85/150 (56%), Gaps = 3/150 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE K DG+ KW LEH G F P YEP Y+G E+ L P AEEVA+FY+
Sbjct: 376 WKWWEEEKKDDGK-KWKFLEHKGPVFAPPYEPLPDHVKFYYDGKEMKLTPEAEEVASFYS 434
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ KE F +NFF D+R ++++++ KVI L+KC+F + A+ D AEK
Sbjct: 435 KMLDHDYTTKEVFNNNFFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMD-----LAEK 488
Query: 441 KAQTTAERKEA-REAEAERVRQFTVALVDG 527
T E K+A +E ++++ +DG
Sbjct: 489 NRNRTKEEKQALKEKNEALIKEYGFCNIDG 518
[111][TOP]
>UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
1980 UF-70 RepID=A7EXF7_SCLS1
Length = 911
Score = 103 bits (258), Expect = 6e-21
Identities = 62/166 (37%), Positives = 85/166 (51%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E D +RWW+A K D +KW TL+HNGV FPPEYE P L Y+G+ L L +
Sbjct: 254 ESEEADEVYRWWDAPKKEDDSIKWETLQHNGVVFPPEYEPLPKNVKLGYDGIPLTLSLES 313
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EE+A F+ + L + H V F+ NFF DF + T AK I K DF
Sbjct: 314 EEIAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKP 373
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + + K E+KA++ AE+K + A+ E + + DGR
Sbjct: 374 IFEYYDG----KSTERKARSAAEKKAEKAAKDEAEAPYKTCIWDGR 415
[112][TOP]
>UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura
RepID=B5DMS2_DROPS
Length = 1054
Score = 103 bits (257), Expect = 7e-21
Identities = 61/161 (37%), Positives = 87/161 (54%), Gaps = 3/161 (1%)
Frame = +3
Query: 54 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLP 227
GA E E + +RWWE + DG VKW+TLEH G F P YE P Y+G L L
Sbjct: 485 GAKEEE--EEVWRWWEEEKREDG-VKWSTLEHKGPVFAPPYERVPRNVRFFYDGRPLDLS 541
Query: 228 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 407
EE ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + +
Sbjct: 542 EETEEAATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYF 600
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDG 527
+ E +EK+ Q T E K A++ E E ++++ ++DG
Sbjct: 601 QAE-----SEKRKQATKEEKLAKKNENEALIKEYGFCMIDG 636
[113][TOP]
>UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE
Length = 1042
Score = 103 bits (257), Expect = 7e-21
Identities = 61/161 (37%), Positives = 87/161 (54%), Gaps = 3/161 (1%)
Frame = +3
Query: 54 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLP 227
GA E E + +RWWE + DG VKW+TLEH G F P YE P Y+G L L
Sbjct: 473 GAKEEE--EEVWRWWEEEKREDG-VKWSTLEHKGPVFAPPYERVPRNVRFFYDGRPLDLS 529
Query: 228 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 407
EE ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + +
Sbjct: 530 EETEEAATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYF 588
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDG 527
+ E +EK+ Q T E K A++ E E ++++ ++DG
Sbjct: 589 QAE-----SEKRKQATKEEKLAKKNENEALIKEYGFCMIDG 624
[114][TOP]
>UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN
Length = 990
Score = 102 bits (255), Expect = 1e-20
Identities = 55/149 (36%), Positives = 79/149 (53%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE + DG VKW+TLEH G F P YE P Y+G L L EE ATFYA
Sbjct: 444 WRWWEEEKREDG-VKWSTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAATFYA 502
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ K+ F +NFF DFR + +K ++I KC+F + + + E K+KA
Sbjct: 503 KMLNHDYCTKDVFNTNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEKRKAAT 561
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K + A++ E V+++ ++DG
Sbjct: 562 KEEKLAKKNE----NEALVKEYGFCMIDG 586
[115][TOP]
>UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana
B05.10 RepID=A6S3Q9_BOTFB
Length = 912
Score = 102 bits (255), Expect = 1e-20
Identities = 62/166 (37%), Positives = 84/166 (50%), Gaps = 10/166 (6%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E D +RWW+A K D +KW TL+HNGV FPPEYE P L Y+G+ L L +
Sbjct: 255 ESEEADEVYRWWDAPKKEDDSIKWETLQHNGVVFPPEYEPLPKNVKLRYDGIPLTLSLES 314
Query: 237 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 392
EE+A F+ + L + H V F+ NFF DF + T AK I K DF
Sbjct: 315 EEIAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKP 374
Query: 393 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
I + + + ++KA A+ AE+ EAEA + + DGR
Sbjct: 375 IFEYYDGKSTERKARSAAEKKAEKALKDEAEA----PYKTCIWDGR 416
[116][TOP]
>UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster
RepID=Q494M1_DROME
Length = 974
Score = 102 bits (254), Expect = 2e-20
Identities = 60/177 (33%), Positives = 87/177 (49%), Gaps = 2/177 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 179
K + +SPG+ + E E +RWWE + DG VKW+TLEH G F P YE
Sbjct: 404 KEPEPAVSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 458
Query: 180 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
P Y+G L L EE ATFYA L D+ KE F +NFF DFR + + +
Sbjct: 459 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 517
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+I KC+F + + + E K+KA K + ++ E +++F ++DG
Sbjct: 518 IIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNE----NEALMKEFGFCMIDG 570
[117][TOP]
>UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster
RepID=TOP1_DROME
Length = 972
Score = 102 bits (254), Expect = 2e-20
Identities = 60/177 (33%), Positives = 87/177 (49%), Gaps = 2/177 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 179
K + +SPG+ + E E +RWWE + DG VKW+TLEH G F P YE
Sbjct: 402 KEPEPAVSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 456
Query: 180 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
P Y+G L L EE ATFYA L D+ KE F +NFF DFR + + +
Sbjct: 457 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 515
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+I KC+F + + + E K+KA K + ++ E +++F ++DG
Sbjct: 516 IIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNE----NEALMKEFGFCMIDG 568
[118][TOP]
>UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG
Length = 622
Score = 102 bits (253), Expect = 2e-20
Identities = 61/158 (38%), Positives = 84/158 (53%), Gaps = 6/158 (3%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 242
E +RWWE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEE
Sbjct: 23 EEEQSRWRWWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEE 81
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 410
VA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I +A +E
Sbjct: 82 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 140
Query: 411 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
K K EK RK +EA + + ++ L+D
Sbjct: 141 ARKNMSKEEKLVCNIQFRKVLKEANQKILDEYGYCLLD 178
[119][TOP]
>UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH
Length = 917
Score = 101 bits (252), Expect = 3e-20
Identities = 52/138 (37%), Positives = 86/138 (62%), Gaps = 1/138 (0%)
Frame = +3
Query: 117 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 296
DG+ KW TL+HNGV FPP Y+ HG ++++G + L P EEVAT +A +T++ K K
Sbjct: 364 DGQKKWKTLQHNGVIFPPPYKRHGVKILFQGKPVDLTPEQEEVATMFAVMRETEYYKKPK 423
Query: 297 FRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEA 473
FR NF+ D+R LL +I SL+ CDF+ I E ++++++ KK+ T E++
Sbjct: 424 FRENFWNDWRKLLGKN---HMIKSLDDCDFTPIYEWYMQEKETKKQ-----MTAEEKRIV 475
Query: 474 REAEAERVRQFTVALVDG 527
+E + ++ ++ A++DG
Sbjct: 476 KEEKLKQEEKYMWAVLDG 493
[120][TOP]
>UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE
Length = 970
Score = 101 bits (252), Expect = 3e-20
Identities = 60/177 (33%), Positives = 87/177 (49%), Gaps = 2/177 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 179
K + +SPG+ + + E E +RWWE + DG VKW+TLEH G F P YE
Sbjct: 400 KEPEPIVSPGKRQKTKVKEEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 454
Query: 180 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
P Y+G L L EE ATFYA L D+ KE F +NFF DFR + + +
Sbjct: 455 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 513
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+I KC F + + + E K+KA K + ++ E +++F ++DG
Sbjct: 514 IIKDFRKCGFQEMFNYFQAESEKRKAASKEEKLIKKNE----NEALMKEFGFCMIDG 566
[121][TOP]
>UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster
RepID=Q8IR39_DROME
Length = 581
Score = 101 bits (251), Expect = 4e-20
Identities = 59/171 (34%), Positives = 85/171 (49%), Gaps = 2/171 (1%)
Frame = +3
Query: 21 LSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFP 194
+SPG+ + E E +RWWE + DG VKW+TLEH G F P YE P
Sbjct: 17 VSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVR 71
Query: 195 LIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLE 374
Y+G L L EE ATFYA L D+ KE F +NFF DFR + + ++I
Sbjct: 72 FYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFR 130
Query: 375 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
KC+F + + + E K+KA K + ++ E +++F ++DG
Sbjct: 131 KCNFQEMFNYFQAESEKRKAASKEEKLIKKNE----NEALMKEFGFCMIDG 177
[122][TOP]
>UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME
Length = 581
Score = 101 bits (251), Expect = 4e-20
Identities = 59/171 (34%), Positives = 85/171 (49%), Gaps = 2/171 (1%)
Frame = +3
Query: 21 LSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFP 194
+SPG+ + E E +RWWE + DG VKW+TLEH G F P YE P
Sbjct: 17 VSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVR 71
Query: 195 LIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLE 374
Y+G L L EE ATFYA L D+ KE F +NFF DFR + + ++I
Sbjct: 72 FYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFR 130
Query: 375 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
KC+F + + + E K+KA K + ++ E +++F ++DG
Sbjct: 131 KCNFQEMFNYFQAESEKRKAASKEEKLIKKNE----NEALMKEFGFCMIDG 177
[123][TOP]
>UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI
Length = 997
Score = 101 bits (251), Expect = 4e-20
Identities = 60/175 (34%), Positives = 87/175 (49%), Gaps = 2/175 (1%)
Frame = +3
Query: 9 EDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--P 182
+ T+SP + A E E +RWWE + DG VKW+TLEH G F P YE P
Sbjct: 415 KSETVSPTKRARKDKKDEEEEV----WRWWEEEKREDG-VKWSTLEHKGPVFAPPYERVP 469
Query: 183 HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI 362
Y+G L L EE ATFYA L D+ K+ F +NFF DFR + D + ++I
Sbjct: 470 RNVRFFYDGKPLDLTEETEEAATFYAKMLNHDYCTKDVFNTNFFKDFRKTMTDRE-KEII 528
Query: 363 TSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
KC+F + + E ++KA K + A++ E V+++ ++DG
Sbjct: 529 KDFRKCNFQEMFEFFQAESERRKAATKDEKLAKKNE----NEALVKEYGFCMIDG 579
[124][TOP]
>UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia
guttata RepID=UPI000194BDF0
Length = 662
Score = 100 bits (250), Expect = 5e-20
Identities = 56/158 (35%), Positives = 86/158 (54%), Gaps = 3/158 (1%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 236
E + + ++WWE K DG VKW LEH G YF P YEP Y+G L L A
Sbjct: 92 EEKEAENKWKWWEEEKKEDG-VKWMQLEHRGPYFVPPYEPLPEDVQFYYDGKPLKLSLAT 150
Query: 237 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 416
EE+ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + ++
Sbjct: 151 EEIATFYAKMLNHEYTTKEIFQNNFFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEK 209
Query: 417 KAKKKAEKKAQTTAERKEAREAEAERVR-QFTVALVDG 527
+K K E K+ + EA++++ ++ ++DG
Sbjct: 210 NEARKGLPK-----EEKQKLKEEADKIQEEYGYCILDG 242
[125][TOP]
>UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA
Length = 892
Score = 100 bits (250), Expect = 5e-20
Identities = 54/133 (40%), Positives = 77/133 (57%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV FPP Y+PHG ++Y G + L P YA TD++ K++F+ N
Sbjct: 344 KWTTLVHNGVIFPPPYKPHGVKMLYMGRPVDLTPELRRGCYKYAVMRDTDYMQKDRFKEN 403
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 488
F+ D+R LL VI +L+ CDF+ I + EK K KK TT E+K +E +
Sbjct: 404 FWNDWRKLLGRN---HVIQNLKDCDFTPIYDWCQSEKEK----KKQMTTEEKKALKEEKL 456
Query: 489 ERVRQFTVALVDG 527
++ ++T A+VDG
Sbjct: 457 KQEEKYTWAIVDG 469
[126][TOP]
>UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR
Length = 1063
Score = 100 bits (250), Expect = 5e-20
Identities = 55/149 (36%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE + DG VKWTTLEH G F P YE P Y+G L L EE ATFYA
Sbjct: 503 WRWWEEKRRDDG-VKWTTLEHKGPVFAPPYERVPQNVRFFYDGKPLELSEETEEAATFYA 561
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ K+ F +NFF DFR + K ++I KC+F + + E K+KA
Sbjct: 562 KMLNHDYCTKDVFNTNFFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEKRKAAT 620
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K + ++ E V+++ ++DG
Sbjct: 621 KEEKLLKKNE----NEALVKEYGFCMIDG 645
[127][TOP]
>UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2
Length = 745
Score = 100 bits (250), Expect = 5e-20
Identities = 56/151 (37%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE N+ D +KW TL+HNGV FPP Y+P L Y+G + LPP AEEVA F+A
Sbjct: 107 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 165
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE-AHLEDEKAKKKAE 437
+ L++DH F+ NFF DF +L ++ + +E +FSR + + D +K +
Sbjct: 166 ALLESDHAKNPVFQKNFFNDFLQVLKES--GGPLNGIEIKEFSRCDFTKMFDYFQLQKEQ 223
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK T+ E+K+ R + + +DGR
Sbjct: 224 KKQLTSQEKKQIRLEREKFEEDYKFCELDGR 254
[128][TOP]
>UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae
RepID=B3LJ50_YEAS1
Length = 769
Score = 100 bits (250), Expect = 5e-20
Identities = 56/151 (37%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE N+ D +KW TL+HNGV FPP Y+P L Y+G + LPP AEEVA F+A
Sbjct: 131 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 189
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE-AHLEDEKAKKKAE 437
+ L++DH F+ NFF DF +L ++ + +E +FSR + + D +K +
Sbjct: 190 ALLESDHAKNPVFQKNFFNDFLQVLKES--GGPLNGIEIKEFSRCDFTKMFDYFQLQKEQ 247
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK T+ E+K+ R + + +DGR
Sbjct: 248 KKQLTSQEKKQIRLEREKFEEDYKFCELDGR 278
[129][TOP]
>UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae
RepID=TOP1_YEAST
Length = 769
Score = 100 bits (250), Expect = 5e-20
Identities = 56/151 (37%), Positives = 85/151 (56%), Gaps = 3/151 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE N+ D +KW TL+HNGV FPP Y+P L Y+G + LPP AEEVA F+A
Sbjct: 131 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 189
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE-AHLEDEKAKKKAE 437
+ L++DH F+ NFF DF +L ++ + +E +FSR + + D +K +
Sbjct: 190 ALLESDHAKNPVFQKNFFNDFLQVLKES--GGPLNGIEIKEFSRCDFTKMFDYFQLQKEQ 247
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KK T+ E+K+ R + + +DGR
Sbjct: 248 KKQLTSQEKKQIRLEREKFEEDYKFCELDGR 278
[130][TOP]
>UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299
RepID=C1FD86_9CHLO
Length = 635
Score = 100 bits (249), Expect = 6e-20
Identities = 61/162 (37%), Positives = 86/162 (53%), Gaps = 3/162 (1%)
Frame = +3
Query: 54 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPA 233
G+A+ + W A K + W+TLEHNGV FPP Y+ HG PL+Y+G ++ L P
Sbjct: 88 GSAKKKTKRADHEPWRA--KRGAKQMWSTLEHNGVVFPPPYQAHGIPLVYDGHDVKLLPH 145
Query: 234 AEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED 413
EEVATF+A TD+ K+ F NFF F+ L I +KCDF++I
Sbjct: 146 EEEVATFFAVMKDTDYAQKDIFVKNFFDGFKKTLRGGPHG-FIKDFKKCDFTKIYMWNLQ 204
Query: 414 EKAKKK---AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
E+ +KK AE+K + AE+ A E ++ A +DGR
Sbjct: 205 ERERKKSVSAEEKRKVKAEQAAAEE-------KYCWATIDGR 239
[131][TOP]
>UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI
Length = 1045
Score = 100 bits (249), Expect = 6e-20
Identities = 55/149 (36%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE + DG VKWTTLEH G F P YE P Y+G L L EE ATFYA
Sbjct: 485 WRWWEEEKREDG-VKWTTLEHKGPVFAPPYERMPRNVRFYYDGKPLELSEETEEAATFYA 543
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ K+ F +NFF DFR + K ++I KC+F + E K+KA
Sbjct: 544 KMLNHDYCTKDVFNNNFFKDFRKSMT-PKEKEIIKDFRKCNFQEMHQFFLAESEKRKAAT 602
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K + A++ E ++++ ++DG
Sbjct: 603 KEEKLAKKNE----NEALIKEYGFCMIDG 627
[132][TOP]
>UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER
Length = 969
Score = 100 bits (249), Expect = 6e-20
Identities = 60/177 (33%), Positives = 87/177 (49%), Gaps = 2/177 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 179
K E +SP + + + E E +RWWE + DG VKW+TLEH G F P YE
Sbjct: 399 KKEPEVVSPTKRQKAKVKEEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 453
Query: 180 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
P Y+G + L EE ATFYA L D+ KE F +NFF DFR + +K +
Sbjct: 454 VPRNVRFYYDGKPMELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKERE 512
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+I KC F+ + + E K+KA K + ++ E +++F ++DG
Sbjct: 513 IIKDFRKCGFNEMFNFFQAESEKRKAATKEEKLIKKNE----NEALMKEFGFCMIDG 565
[133][TOP]
>UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus
RepID=TOP1M_MOUSE
Length = 593
Score = 100 bits (249), Expect = 6e-20
Identities = 60/147 (40%), Positives = 84/147 (57%), Gaps = 3/147 (2%)
Frame = +3
Query: 96 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 269
WE +K+ VKW LEH G YF P YEP G +Y+G L L AAEEVATFY L
Sbjct: 36 WEETSKSS--VKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKML 93
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
+ KE FR NFF+D+R + + ++IT L+KCDF+ I H ++AE +
Sbjct: 94 HLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHF-----LERAEARRT 147
Query: 450 TTAERKEAREAEAERVRQ-FTVALVDG 527
E+K+ + EAE+++Q F ++DG
Sbjct: 148 LPREQKQKLKEEAEKLQQEFGYCVLDG 174
[134][TOP]
>UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545
RepID=C1MGX0_9CHLO
Length = 685
Score = 99.8 bits (247), Expect = 1e-19
Identities = 51/135 (37%), Positives = 81/135 (60%), Gaps = 1/135 (0%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
+W TLEH+GV FPP YEP+ PL Y+G+++ L P EE A F+A TD+ K+ F N
Sbjct: 163 QWKTLEHHGVVFPPPYEPNKVPLTYDGVDIVLLPHEEEAANFFAVMKDTDYAQKDVFVKN 222
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 485
F+ F+ +L A I +KCDF+++ HL K++ +KKA + ++K+A+ A+
Sbjct: 223 FWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHL-----KEREKKKAISNEDKKKAKAAK 277
Query: 486 AERVRQFTVALVDGR 530
++ A++DGR
Sbjct: 278 DAEEEKYNWAVIDGR 292
[135][TOP]
>UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA
Length = 580
Score = 99.8 bits (247), Expect = 1e-19
Identities = 55/149 (36%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE + DG VKW+TLEH G F P YE P Y+G L L EE ATFYA
Sbjct: 34 WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYA 92
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ KE F +NFF DFR + +K ++I KC F + + E K+KA
Sbjct: 93 KMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEKRKAAT 151
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K + ++ E +++F ++DG
Sbjct: 152 KEEKLIKKNE----NEALMKEFGFCMIDG 176
[136][TOP]
>UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO
Length = 701
Score = 99.8 bits (247), Expect = 1e-19
Identities = 59/159 (37%), Positives = 83/159 (52%), Gaps = 14/159 (8%)
Frame = +3
Query: 90 RWWEAGNKTDGEVK-------------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPP 230
RWWE K D E W LEHNG+ F PEY+PHG P+ ++G + L P
Sbjct: 92 RWWE---KVDNEFDLAKIMEYENQSCHWEYLEHNGMIFTPEYKPHGIPIKFKGEPITLTP 148
Query: 231 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK-FAKVITSLEKCDFSRIEAHL 407
EEVATF+A + T++ E +R NF+ F ++ K +L+ CDFS I AHL
Sbjct: 149 DLEEVATFWAQSIGTNYEESEIYRRNFWNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHL 208
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
+ E+ KKK +K+ K +E A++ + ALVD
Sbjct: 209 DMEREKKKEQKEYY-----KALKEETAKKEHPYCYALVD 242
[137][TOP]
>UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis
RepID=UPI00017B3173
Length = 622
Score = 99.4 bits (246), Expect = 1e-19
Identities = 60/154 (38%), Positives = 85/154 (55%), Gaps = 2/154 (1%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 242
E +RWWE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEE
Sbjct: 47 EEEQSRWRWWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEE 105
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 422
VA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I A KA
Sbjct: 106 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAM---HKA 161
Query: 423 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
K +A +K + E+ +EA + + ++ L+D
Sbjct: 162 KVEA-RKNMSKEEKLVLKEANQKILDEYGYCLLD 194
[138][TOP]
>UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5C65
Length = 755
Score = 99.4 bits (246), Expect = 1e-19
Identities = 58/148 (39%), Positives = 82/148 (55%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G L AEEVATF+A
Sbjct: 193 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFA 251
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA+ +A +
Sbjct: 252 KMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-R 306
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
KA T E+ + +E ++Q+ ++D
Sbjct: 307 KAMTKEEKLKIKEENERLLQQYGFCIMD 334
[139][TOP]
>UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU
Length = 753
Score = 99.4 bits (246), Expect = 1e-19
Identities = 58/148 (39%), Positives = 82/148 (55%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G L AEEVATF+A
Sbjct: 191 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFA 249
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA+ +A +
Sbjct: 250 KMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-R 304
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
KA T E+ + +E ++Q+ ++D
Sbjct: 305 KAMTKEEKLKIKEENERLLQQYGFCIMD 332
[140][TOP]
>UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE
Length = 592
Score = 99.4 bits (246), Expect = 1e-19
Identities = 61/147 (41%), Positives = 85/147 (57%), Gaps = 3/147 (2%)
Frame = +3
Query: 96 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 269
WE +K+ VKW LEH G YF P YEP G +Y+G L L AAEEVATFY L
Sbjct: 36 WEETSKSS--VKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKML 93
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
+ KE FR NFF+D+R + + ++IT L+KCDF+ I H ++AE +
Sbjct: 94 HLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHF-----LERAEARRT 147
Query: 450 TTAERKEAREAEAERVRQ-FTVALVDG 527
E+K+ +E EAE+++Q F ++DG
Sbjct: 148 LPREQKQLKE-EAEKLQQEFGYCVLDG 173
[141][TOP]
>UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis
RepID=UPI00017B27B1
Length = 751
Score = 99.0 bits (245), Expect = 2e-19
Identities = 59/148 (39%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G + L AEEVATF+A
Sbjct: 189 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 247
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA+ +A +
Sbjct: 248 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-R 302
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
KA T E+ + +E ++QF ++D
Sbjct: 303 KAMTKEEKLKIKEENERILQQFGFCIMD 330
[142][TOP]
>UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis
RepID=UPI00017B27B0
Length = 751
Score = 99.0 bits (245), Expect = 2e-19
Identities = 59/148 (39%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G + L AEEVATF+A
Sbjct: 189 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 247
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA+ +A +
Sbjct: 248 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-R 302
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
KA T E+ + +E ++QF ++D
Sbjct: 303 KAMTKEEKLKIKEENERILQQFGFCIMD 330
[143][TOP]
>UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5A48
Length = 632
Score = 99.0 bits (245), Expect = 2e-19
Identities = 62/148 (41%), Positives = 83/148 (56%), Gaps = 3/148 (2%)
Frame = +3
Query: 90 RW-WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
RW WE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEEVA F+A
Sbjct: 69 RWRWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDNVHFYYDGKKVKLSLAAEEVALFFA 127
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + D + +I L KCDF I A KAK +A +
Sbjct: 128 QMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKAKVEA-R 182
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K T E++ +EA + V +F L+D
Sbjct: 183 KNMTKEEKQALKEANQKIVDEFGYCLLD 210
[144][TOP]
>UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE
Length = 469
Score = 99.0 bits (245), Expect = 2e-19
Identities = 56/148 (37%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G + L P AEEVATF++
Sbjct: 196 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFS 254
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + +K IT L KCDFS + + KA+ +A +
Sbjct: 255 KMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-R 309
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
KA T E+ + +E ++++ ++D
Sbjct: 310 KAMTKEEKLKIKEENERILQEYGFCIMD 337
[145][TOP]
>UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE
Length = 758
Score = 99.0 bits (245), Expect = 2e-19
Identities = 56/148 (37%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G + L P AEEVATF++
Sbjct: 196 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFS 254
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + +K IT L KCDFS + + KA+ +A +
Sbjct: 255 KMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-R 309
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
KA T E+ + +E ++++ ++D
Sbjct: 310 KAMTKEEKLKIKEENERILQEYGFCIMD 337
[146][TOP]
>UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR
Length = 767
Score = 99.0 bits (245), Expect = 2e-19
Identities = 52/148 (35%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP G Y+G + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFA 263
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + VIT+L KCDF+++ + +D+ +K
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSEARKQMS 322
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K E+ + +E + ++++ ++D
Sbjct: 323 K----EEKLKIKEENEKLLKEYGFCVMD 346
[147][TOP]
>UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum
RepID=UPI0001792028
Length = 1011
Score = 98.6 bits (244), Expect = 2e-19
Identities = 55/149 (36%), Positives = 77/149 (51%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE K DG VKW LEH G F P YEP Y G ++ L AEEVATFYA
Sbjct: 187 WKWWEEEKKDDG-VKWKFLEHKGPVFAPAYEPLPSNVKFYYNGKQVVLSELAEEVATFYA 245
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L+ D+ KE F NF D+R + K ++IT L C+F + + KK E+
Sbjct: 246 KMLEHDYTTKEVFNKNFLKDWRKTMT-PKEKELITDLSLCNFKEMNVYF----TKKSEER 300
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
KA + E+K+ +E +++ +DG
Sbjct: 301 KAMSKEEKKKIKEENEALQKEYGFCTIDG 329
[148][TOP]
>UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus
RepID=UPI0000ECD01B
Length = 593
Score = 98.2 bits (243), Expect = 3e-19
Identities = 58/154 (37%), Positives = 83/154 (53%), Gaps = 3/154 (1%)
Frame = +3
Query: 75 GDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVA 248
G GG WE DG VKW LEH G YF P YEP Y+G L L A EE+A
Sbjct: 27 GSGGCSRWEEEKTNDG-VKWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIA 85
Query: 249 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK 428
TFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ +
Sbjct: 86 TFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEAR 144
Query: 429 KAEKKAQTTAERKEAREAEAERVR-QFTVALVDG 527
KA K E K+ + EA++++ ++ ++DG
Sbjct: 145 KALSK-----EEKQKLKEEADKIQEEYGYCILDG 173
[149][TOP]
>UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus
RepID=Q6T722_CHICK
Length = 593
Score = 98.2 bits (243), Expect = 3e-19
Identities = 58/154 (37%), Positives = 83/154 (53%), Gaps = 3/154 (1%)
Frame = +3
Query: 75 GDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVA 248
G GG WE DG VKW LEH G YF P YEP Y+G L L A EE+A
Sbjct: 27 GSGGCSRWEEEKTNDG-VKWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIA 85
Query: 249 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK 428
TFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ +
Sbjct: 86 TFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEAR 144
Query: 429 KAEKKAQTTAERKEAREAEAERVR-QFTVALVDG 527
KA K E K+ + EA++++ ++ ++DG
Sbjct: 145 KALSK-----EEKQKLKEEADKIQEEYGYCILDG 173
[150][TOP]
>UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1
Tax=Ornithorhynchus anatinus RepID=UPI0001555600
Length = 689
Score = 97.8 bits (242), Expect = 4e-19
Identities = 56/156 (35%), Positives = 84/156 (53%), Gaps = 3/156 (1%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 242
+ G ++WWE + DG VKW LEH G YF P YEP Y G + L EE
Sbjct: 121 DEGASKWKWWEEEKREDG-VKWKQLEHRGPYFAPLYEPLPDHVHFYYNGKPMKLSLVTEE 179
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 422
+ATFY L ++ K+ F++NFF+D+R + + K I LE+CDF+ I + D+
Sbjct: 180 IATFYGKMLDHEYTTKDIFQNNFFSDWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNE 238
Query: 423 KKKAEKKAQTTAERKEAREAEAERVR-QFTVALVDG 527
+KA K E K+ + EAE+++ +F ++DG
Sbjct: 239 ARKALPK-----EEKQKLKEEAEKLQEEFGYCILDG 269
[151][TOP]
>UniRef100_Q504F2 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q504F2_DANRE
Length = 321
Score = 96.7 bits (239), Expect = 9e-19
Identities = 55/132 (41%), Positives = 76/132 (57%), Gaps = 2/132 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G + L P AEEVATF++
Sbjct: 196 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFS 254
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + +K IT L KCDFS + + KA+ +A +
Sbjct: 255 KMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-R 309
Query: 441 KAQTTAERKEAR 476
KA T E+K+ +
Sbjct: 310 KAMTKEEKKKKK 321
[152][TOP]
>UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16
RepID=A8XXL4_CAEBR
Length = 840
Score = 96.7 bits (239), Expect = 9e-19
Identities = 54/149 (36%), Positives = 84/149 (56%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
+ WW+ K DG VKW TL+H G F P Y P Y G + L PAAEE ATFYA
Sbjct: 264 WEWWKEEKKPDG-VKWNTLQHCGPLFAPAYIPLPDHVHFKYNGHRMKLSPAAEECATFYA 322
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
+ ++ + +F +NF D+R L+ + K IT L KCDF+ H+ + + +++ +
Sbjct: 323 GVVNHEYSSQVQFNTNFMKDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNEQREIR 377
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
KA T E+ + +E +A+ V + +A++DG
Sbjct: 378 KAMTKEEKAKIKEEKAQEVVDYGIAIIDG 406
[153][TOP]
>UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus
RepID=TOP1M_RAT
Length = 593
Score = 96.3 bits (238), Expect = 1e-18
Identities = 57/144 (39%), Positives = 79/144 (54%), Gaps = 3/144 (2%)
Frame = +3
Query: 105 GNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTD 278
G + VKW LEH G F P YEP G Y+G + L AAEEVATFY L +
Sbjct: 37 GETSKSSVKWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLE 96
Query: 279 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 458
KE FR NFF+D++ + + K+IT L+KCDFS I H ++AE +
Sbjct: 97 CTTKEVFRRNFFSDWQKEMT-AEERKLITHLDKCDFSEIHRHF-----MERAEARRTLPR 150
Query: 459 ERKEAREAEAERVRQ-FTVALVDG 527
E+K+ + EAE+++Q F ++DG
Sbjct: 151 EQKQKLKEEAEKLQQEFGYCILDG 174
[154][TOP]
>UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva
RepID=Q4N5U3_THEPA
Length = 1003
Score = 95.9 bits (237), Expect = 2e-18
Identities = 57/158 (36%), Positives = 82/158 (51%), Gaps = 13/158 (8%)
Frame = +3
Query: 90 RWWEAGNKTDGEV-------------KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPP 230
RWWE + DG++ +W LEHNG+ F PEY PH P+ +G +HLPP
Sbjct: 313 RWWE---EIDGDMDYNKGLEFESKSSRWKYLEHNGMIFTPEYVPHNVPIKVKGETIHLPP 369
Query: 231 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLE 410
EE+AT +A + T++ + + NF+ F + F + L DFS I+ HLE
Sbjct: 370 HLEEIATMWAQSIGTNYETSDIYCKNFWQVFVSKFEKDHFIR-RCKLTDVDFSLIKTHLE 428
Query: 411 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
DEK KKK K+ K ++ +A+R +F ALVD
Sbjct: 429 DEKQKKKDNKEFY-----KAKQQEDAKREYRFNYALVD 461
[155][TOP]
>UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA
Length = 790
Score = 95.9 bits (237), Expect = 2e-18
Identities = 54/130 (41%), Positives = 78/130 (60%), Gaps = 1/130 (0%)
Frame = +3
Query: 141 LEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFAD 320
L HNGV FPP Y+PHG ++Y + L P EEVAT +A L+T+++ K KFR NF +D
Sbjct: 220 LVHNGVIFPPLYKPHGVKMLYRENPVDLTPEQEEVATMFAVMLETEYMTKPKFRENFMSD 279
Query: 321 FRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE-RV 497
+R +L + +I +LE CDF+ I + EK K KK +T E+K +E + E R
Sbjct: 280 WRKILGE---KHIIQNLEDCDFTPIYEWHQREKEK----KKQMSTDEKKAIKEGKDETRK 332
Query: 498 RQFTVALVDG 527
++ A+VDG
Sbjct: 333 EKYMWAVVDG 342
[156][TOP]
>UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi
RepID=A8Q2Z1_BRUMA
Length = 751
Score = 95.5 bits (236), Expect = 2e-18
Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 2/155 (1%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 242
E+ + ++WWE K G +KW +L H G F P Y P Y+G + L P EE
Sbjct: 193 EDEEEVWKWWEEEKKPSG-IKWYSLSHKGPIFAPPYVSLPESIHFKYDGKVMKLAPLTEE 251
Query: 243 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 422
VA+FYA L+ ++ K+ F NFF D+R ++ + K IT L KCDF + D
Sbjct: 252 VASFYAKILEHEYTTKDIFNKNFFTDWRKVMTPAEREK-ITDLTKCDF----REMHDHYI 306
Query: 423 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
K + E+++ + E+++ +E + E + + VA +DG
Sbjct: 307 KLREERRSLSKEEKQKLKEIKQEEAKIYGVAYIDG 341
[157][TOP]
>UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus
norvegicus RepID=UPI0001B7BF13
Length = 760
Score = 95.1 bits (235), Expect = 3e-18
Identities = 52/148 (35%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP G Y+G + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLQEGVKFYYDGKVMKLSPKAEEVATFFA 261
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA+ +A +
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEA-R 316
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 317 KQMSKEEKLKIKEENEKLLKEYGFCVMD 344
[158][TOP]
>UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata
RepID=Q4UDP8_THEAN
Length = 999
Score = 95.1 bits (235), Expect = 3e-18
Identities = 55/155 (35%), Positives = 80/155 (51%), Gaps = 10/155 (6%)
Frame = +3
Query: 90 RWWEAGNKT----------DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
RWWE ++ +W LEHNG+ F PEY PH P++ +G +HLPP E
Sbjct: 314 RWWEEIDEDMDYNKGLEFESKSSRWKYLEHNGMIFTPEYVPHNIPIMVKGETIHLPPNLE 373
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 419
E+AT +A + T++ E + NF+ F + F + L DFS I+ HLE+EK
Sbjct: 374 EIATMWAQSMGTNYETSEIYCKNFWQVFVSKFEKDHFIR-RCKLSDADFSLIKNHLEEEK 432
Query: 420 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
KKK K+ K ++ +A+R +F ALVD
Sbjct: 433 QKKKDNKEFY-----KAKQQEDAKREYRFNYALVD 462
[159][TOP]
>UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR
Length = 874
Score = 95.1 bits (235), Expect = 3e-18
Identities = 56/145 (38%), Positives = 79/145 (54%), Gaps = 11/145 (7%)
Frame = +3
Query: 87 FRWWE-AGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFY 257
++WWE + K D +KWTTLEHNGV FP +Y+ P L+Y+G + L AEE ATF+
Sbjct: 224 YKWWEESAKKEDDSIKWTTLEHNGVIFPEDYQRLPKDVKLLYDGTPVELDIEAEEAATFF 283
Query: 258 ASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLED 413
L T +V F+ NFF DF+ +L T AK I EK DFS++ A+ +
Sbjct: 284 GFMLNSTVNVENPTFQKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWAYKDA 343
Query: 414 EKAKKKAEKKAQTTAERKEAREAEA 488
+ K A A+ AE+ E + +A
Sbjct: 344 QTKAKNARSSAEKKAEKAERDKRDA 368
[160][TOP]
>UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT
Length = 767
Score = 95.1 bits (235), Expect = 3e-18
Identities = 52/148 (35%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP G Y+G + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFA 263
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA+ +A +
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEA-R 318
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 319 KQMSKEEKLKIKEENEKLLKEYGFCVMD 346
[161][TOP]
>UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus
caballus RepID=UPI0001797824
Length = 765
Score = 94.7 bits (234), Expect = 3e-18
Identities = 52/148 (35%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 261
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +ITSL KCDF+++ + KA+ +A +
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF---KAQTEA-R 316
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 317 KQMSKEEKLKIKEENEKLLKEYGFCVMD 344
[162][TOP]
>UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus
scrofa RepID=UPI00017EFDA4
Length = 748
Score = 94.4 bits (233), Expect = 5e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 187 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 245
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 246 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEA-R 300
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 301 KQMSKEEKLKIKEENEKLLKEYGFCIMD 328
[163][TOP]
>UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta
RepID=UPI00006D45A8
Length = 767
Score = 94.4 bits (233), Expect = 5e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEA-R 318
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 319 KQMSKEEKLKIKEENEKLLKEYGFCIMD 346
[164][TOP]
>UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus
familiaris RepID=UPI00005A45B7
Length = 1004
Score = 94.0 bits (232), Expect = 6e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 442 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 500
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 501 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEA-R 555
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 556 KQMSKEEKLKIKEENEKLLKEYGFCVMD 583
[165][TOP]
>UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30
Length = 752
Score = 94.0 bits (232), Expect = 6e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 190 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 248
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 249 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEA-R 303
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 304 KQMSKEEKLKIKEENEKLLKEYGFCVMD 331
[166][TOP]
>UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN
Length = 765
Score = 94.0 bits (232), Expect = 6e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 261
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEA-R 316
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 317 KQMSKEEKLKIKEENEKLLKEYGFCIMD 344
[167][TOP]
>UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA
Length = 829
Score = 94.0 bits (232), Expect = 6e-18
Identities = 54/141 (38%), Positives = 77/141 (54%), Gaps = 2/141 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE DG +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 259 WKWWEEERHRDG-IKWKFLEHKGPVFAPPYEPVPDNVKFYYDGNLVKLSPKAEEVATFFA 317
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D++ + T +IT+L KCDF+ + + K+++E
Sbjct: 318 KMLDHEYTTKDIFRKNFFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF-----KEQSEA 371
Query: 441 KAQTTAERKEAREAEAERVRQ 503
+ T E K +AE ER+ Q
Sbjct: 372 RKNMTKEEKLKIKAENERLLQ 392
[168][TOP]
>UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN
Length = 765
Score = 94.0 bits (232), Expect = 6e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 261
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEA-R 316
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 317 KQMSKEEKLKIKEENEKLLKEYGFCIMD 344
[169][TOP]
>UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1
Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294
Length = 786
Score = 93.6 bits (231), Expect = 8e-18
Identities = 54/142 (38%), Positives = 79/142 (55%), Gaps = 3/142 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE DG +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 222 WKWWEEERHADG-IKWKFLEHKGPVFAPPYEPLPDNVKFYYDGNLVKLSPKAEEVATFFA 280
Query: 261 SKLQTDHVLKEKFRSNFFADF-RALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAE 437
L ++ K+ FR NFF D+ + + AD + +IT+L KCDF+ + + K+++E
Sbjct: 281 KMLDHEYTTKDIFRKNFFKDWKKEMTADER--NLITNLGKCDFNAMSQYF-----KEQSE 333
Query: 438 KKAQTTAERKEAREAEAERVRQ 503
+ T E K+ + E ER+ Q
Sbjct: 334 ARKNMTKEEKQKIKEENERLLQ 355
[170][TOP]
>UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus
RepID=UPI00006154BF
Length = 769
Score = 93.6 bits (231), Expect = 8e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 207 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 265
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 266 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEA-R 320
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 321 KQMSKEEKLKIKEENEKLLKEYGFCVMD 348
[171][TOP]
>UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE
Length = 767
Score = 93.6 bits (231), Expect = 8e-18
Identities = 51/148 (34%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPDSVKFYYDGKVMKLSPKAEEVATFFA 263
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEA-R 318
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 319 KQMSKEEKLKIKEENEKLLKEYGFCIMD 346
[172][TOP]
>UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5A49
Length = 692
Score = 93.2 bits (230), Expect = 1e-17
Identities = 59/155 (38%), Positives = 81/155 (52%), Gaps = 10/155 (6%)
Frame = +3
Query: 90 RW-WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
RW WE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEEVA F+A
Sbjct: 68 RWRWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDNVHFYYDGKKVKLSLAAEEVALFFA 126
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAE 437
L ++ K+ FR NFF D+R + D + +I L KCDF I A H +A+K
Sbjct: 127 QMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAMHKAKVEARKNMT 185
Query: 438 KKAQTTAE------RKEAREAEAERVRQFTVALVD 524
K+ + + +EA + V +F L+D
Sbjct: 186 KEEKQVCNIHFIMLKNALKEANQKIVDEFGYCLLD 220
[173][TOP]
>UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG
RepID=B9Q6S5_TOXGO
Length = 953
Score = 93.2 bits (230), Expect = 1e-17
Identities = 58/173 (33%), Positives = 88/173 (50%), Gaps = 21/173 (12%)
Frame = +3
Query: 69 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
EN + RWWE A + + E +W+ LEHNG+ F P YEPHG L Y G + LPP AE
Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQLTYHGKPVSLPPEAE 343
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 374
EVA ++ L++D+ K +F NF+ F +L + FA+ + E
Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403
Query: 375 ---KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD
Sbjct: 404 GFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVD 452
[174][TOP]
>UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0
Length = 758
Score = 92.8 bits (229), Expect = 1e-17
Identities = 51/148 (34%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 196 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 254
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA+ +A +
Sbjct: 255 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEA-R 309
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 310 KQMSKEEKLKIKEENEKLLKEYGFCVMD 337
[175][TOP]
>UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG
Length = 806
Score = 92.8 bits (229), Expect = 1e-17
Identities = 55/124 (44%), Positives = 69/124 (55%), Gaps = 6/124 (4%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE TDG VKW LEH G F P YEP Y+G + L AEEVATF+A
Sbjct: 171 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 229
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKK 428
L ++ K+ FR NFF D+R + + AK IT L+KCDFS + +A E KA
Sbjct: 230 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTEARKAMT 288
Query: 429 KAEK 440
K EK
Sbjct: 289 KEEK 292
[176][TOP]
>UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA
Length = 969
Score = 92.8 bits (229), Expect = 1e-17
Identities = 54/150 (36%), Positives = 83/150 (55%), Gaps = 3/150 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE + DG VKW LEH G F P Y+P +Y+G E+ L AEEVA FYA
Sbjct: 428 WKWWEEEKRDDG-VKWKYLEHKGPVFAPPYDPLPSHVKFMYDGKEMKLSQDAEEVAGFYA 486
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L+ D+ K+ F NFF D+R + + + IT LEKC+F + A+ + AE+
Sbjct: 487 RMLEHDYTSKQAFNDNFFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAE-----IAEQ 540
Query: 441 KAQTTAERKEAREAEAERV-RQFTVALVDG 527
+ E K A +A E++ +++ + ++DG
Sbjct: 541 NRNRSKEEKAALKAANEQLTKEYGICVIDG 570
[177][TOP]
>UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE
Length = 767
Score = 92.8 bits (229), Expect = 1e-17
Identities = 51/148 (34%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA+ +A +
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEA-R 318
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+ + +E + ++++ ++D
Sbjct: 319 KQMSKEEKLKIKEENEKLLKEYGFCVMD 346
[178][TOP]
>UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus
anatinus RepID=UPI000155C8C4
Length = 781
Score = 92.4 bits (228), Expect = 2e-17
Identities = 50/148 (33%), Positives = 84/148 (56%), Gaps = 2/148 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 219 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 277
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + + + IT+L KCDF+ + + KA+ +A +
Sbjct: 278 KMLDHEYTTKDIFRKNFFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF---KAQSEA-R 332
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVD 524
K + E+++ +E + ++++ ++D
Sbjct: 333 KQMSKEEKQKIKEENEQLLKEYGFCVMD 360
[179][TOP]
>UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1
RepID=B9PWF4_TOXGO
Length = 953
Score = 92.4 bits (228), Expect = 2e-17
Identities = 57/173 (32%), Positives = 88/173 (50%), Gaps = 21/173 (12%)
Frame = +3
Query: 69 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
EN + RWWE A + + E +W+ LEHNG+ F P YEPHG + Y G + LPP AE
Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAE 343
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 374
EVA ++ L++D+ K +F NF+ F +L + FA+ + E
Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403
Query: 375 ---KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD
Sbjct: 404 GFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVD 452
[180][TOP]
>UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49
RepID=B6KM03_TOXGO
Length = 953
Score = 92.4 bits (228), Expect = 2e-17
Identities = 57/173 (32%), Positives = 88/173 (50%), Gaps = 21/173 (12%)
Frame = +3
Query: 69 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 239
EN + RWWE A + + E +W+ LEHNG+ F P YEPHG + Y G + LPP AE
Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAE 343
Query: 240 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 374
EVA ++ L++D+ K +F NF+ F +L + FA+ + E
Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403
Query: 375 ---KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD
Sbjct: 404 GFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVD 452
[181][TOP]
>UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata
RepID=UPI000194D872
Length = 775
Score = 92.0 bits (227), Expect = 2e-17
Identities = 52/139 (37%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L AEEVATF+A
Sbjct: 213 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFA 271
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + ITSL KCDF+ + + K ++E
Sbjct: 272 KMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQSEA 325
Query: 441 KAQTTAERKEAREAEAERV 497
+ Q + E K+ + E ER+
Sbjct: 326 RKQMSKEEKQKIKEENERL 344
[182][TOP]
>UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica
RepID=UPI0000F2B3E5
Length = 916
Score = 92.0 bits (227), Expect = 2e-17
Identities = 52/139 (37%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 354 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 412
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ K+ FR NFF D+R + + + IT+L KCDF++I + K ++E
Sbjct: 413 KMLDHEYTTKDIFRKNFFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF-----KAQSEA 466
Query: 441 KAQTTAERKEAREAEAERV 497
+ Q + E K + E ER+
Sbjct: 467 RKQMSKEEKLKIKEENERL 485
[183][TOP]
>UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5F97
Length = 790
Score = 92.0 bits (227), Expect = 2e-17
Identities = 56/169 (33%), Positives = 88/169 (52%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +D+ ++ G+ + + + ++WWE TDG KW LEH G F P YEP
Sbjct: 224 KKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPYEP 273
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K
Sbjct: 274 LPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 333
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 503
IT L KC+F+ + +E K ++E + Q + E K+ + + ER+ Q
Sbjct: 334 -ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDNERILQ 376
[184][TOP]
>UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5F96
Length = 767
Score = 92.0 bits (227), Expect = 2e-17
Identities = 56/169 (33%), Positives = 88/169 (52%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +D+ ++ G+ + + + ++WWE TDG KW LEH G F P YEP
Sbjct: 186 KKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPYEP 235
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K
Sbjct: 236 LPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 295
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 503
IT L KC+F+ + +E K ++E + Q + E K+ + + ER+ Q
Sbjct: 296 -ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDNERILQ 338
[185][TOP]
>UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK
Length = 766
Score = 91.7 bits (226), Expect = 3e-17
Identities = 52/139 (37%), Positives = 73/139 (52%), Gaps = 2/139 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L AEEVATF+A
Sbjct: 204 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFA 262
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE FR NFF D+R + + ITSL KCDF+ + + K + E
Sbjct: 263 KMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQTEA 316
Query: 441 KAQTTAERKEAREAEAERV 497
+ Q + E K+ + E ER+
Sbjct: 317 RKQMSKEEKQKIKEENERL 335
[186][TOP]
>UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU
Length = 767
Score = 91.3 bits (225), Expect = 4e-17
Identities = 55/169 (32%), Positives = 87/169 (51%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +D+ ++ G+ + + + ++WWE TDG KW LEH G F P YEP
Sbjct: 186 KKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPYEP 235
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K
Sbjct: 236 LPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 295
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 503
IT L KC+F+ + + K ++E + Q + E K+ + + ER+ Q
Sbjct: 296 -ITDLNKCNFAGMNDYF-----KAQSEARKQMSKEEKQKIKEDNERILQ 338
[187][TOP]
>UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis
RepID=UPI00017B1DB6
Length = 770
Score = 90.9 bits (224), Expect = 5e-17
Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +D+ ++ G+ + + + ++WWE TDG KW L H G F P YEP
Sbjct: 189 KKKDKNVTEGK---------KSKKDEEKWKWWEEERYTDGS-KWRFLGHKGPVFAPPYEP 238
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K
Sbjct: 239 LPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 298
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 503
IT L KC+F+ + +E K ++E + Q + E K+ + E ER+ Q
Sbjct: 299 -ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEENERILQ 341
[188][TOP]
>UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG
Length = 783
Score = 90.9 bits (224), Expect = 5e-17
Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +D+ ++ G+ + + + ++WWE TDG KW L H G F P YEP
Sbjct: 170 KKKDKNVTEGK---------KSKKDEEKWKWWEEERYTDGS-KWRFLGHKGPVFAPPYEP 219
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K
Sbjct: 220 LPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 279
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 503
IT L KC+F+ + +E K ++E + Q + E K+ + E ER+ Q
Sbjct: 280 -ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEENERILQ 322
[189][TOP]
>UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium
parvum Iowa II RepID=Q5CY81_CRYPV
Length = 653
Score = 90.9 bits (224), Expect = 5e-17
Identities = 50/145 (34%), Positives = 72/145 (49%)
Frame = +3
Query: 90 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 269
+WWE K + ++W LEH GV F P Y+ H PL Y G + LPP AEE+A++++
Sbjct: 43 KWWERPPKEELGIQWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMK 102
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
T+ KEKF +N F + EKC+F I+ + EDEK KK K +
Sbjct: 103 DTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEE 162
Query: 450 TTAERKEAREAEAERVRQFTVALVD 524
++K ++ F ALVD
Sbjct: 163 KELQKK----CRGDQESPFVYALVD 183
[190][TOP]
>UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis
RepID=Q5CN58_CRYHO
Length = 641
Score = 90.9 bits (224), Expect = 5e-17
Identities = 50/145 (34%), Positives = 72/145 (49%)
Frame = +3
Query: 90 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 269
+WWE K + ++W LEH GV F P Y+ H PL Y G + LPP AEE+A++++
Sbjct: 31 KWWERPPKEELGIQWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMK 90
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
T+ KEKF +N F + EKC+F I+ + EDEK KK K +
Sbjct: 91 DTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEE 150
Query: 450 TTAERKEAREAEAERVRQFTVALVD 524
++K ++ F ALVD
Sbjct: 151 KELQKK----CRGDQESPFVYALVD 171
[191][TOP]
>UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum
RepID=Q5C1T3_SCHJA
Length = 330
Score = 90.5 bits (223), Expect = 7e-17
Identities = 58/178 (32%), Positives = 85/178 (47%), Gaps = 3/178 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPL-GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE 179
+T + A SP G + + + +RWWE K DG VKW LEH G F P YE
Sbjct: 87 RTTHEKIKKQNALSSPTKGRKQEKPEEEVWRWWEEQKKDDG-VKWKFLEHKGPLFAPPYE 145
Query: 180 --PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFA 353
P Y+ + L AEEVA FYA L D+ KE F NFF D+ + + +
Sbjct: 146 RLPSSVHFHYDSKPMKLSDHAEEVAGFYARMLDHDYTTKEVFNHNFFHDWVKTMNEEE-R 204
Query: 354 KVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
+ I SL KCDF + + K E+K +T E+++ +E + ++ ++DG
Sbjct: 205 RTIKSLSKCDFQEMHQYF----LKLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDG 258
[192][TOP]
>UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)
(TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD
Length = 620
Score = 90.1 bits (222), Expect = 9e-17
Identities = 55/143 (38%), Positives = 84/143 (58%), Gaps = 4/143 (2%)
Frame = +3
Query: 111 KTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEG--MELHLPPAAEEVATFYASKLQTD 278
K+ G VKWT LEH G +F YE P G P + + + L AAEEVATFY KL +
Sbjct: 1 KSPGGVKWTQLEHRGPWFAAPYEPLPEGVPSTTDRLLLTIKLILAAEEVATFYGKKLDRE 60
Query: 279 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 458
+ KE F++NFF+D+R + + +VI L++CDF+ I H D K A +KA +
Sbjct: 61 YT-KEVFQNNFFSDWRKEMT-AEEGRVIKHLDRCDFTEIHRHSVD----KTASQKALSRE 114
Query: 459 ERKEAREAEAERVRQFTVALVDG 527
E+++ +E E + ++F +++DG
Sbjct: 115 EKQKLKEEEEKLQQEFGCSILDG 137
[193][TOP]
>UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102
RepID=C9SIQ6_9PEZI
Length = 891
Score = 90.1 bits (222), Expect = 9e-17
Identities = 57/162 (35%), Positives = 82/162 (50%), Gaps = 6/162 (3%)
Frame = +3
Query: 63 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 236
E E + WW K D VKWTTLEHNGV +YE P L+Y+G L+LP
Sbjct: 235 EAEEDEAVDEWWNEPKKEDDSVKWTTLEHNGVLMDYKYEPLPKNVKLVYDGKPLNLPLQV 294
Query: 237 EEVATFYASKLQT-DHVLKEKFRSNFFADFRALLADTKFA--KVITSLEKCDFSRIE-AH 404
EE A F+ S + ++V F+ NFF DFR ++ + A K ++ DF +I
Sbjct: 295 EEAAWFFGSMFHSKNNVDNPTFQKNFFEDFREVIKEHGSATDKDGKKVDIKDFHKINWQP 354
Query: 405 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
+ D ++ A +K +T E+K+ +E + R F L DGR
Sbjct: 355 MADYAEQQSAMRKNRTKEEKKQIKEEKDAREEPFKYCLWDGR 396
[194][TOP]
>UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni
RepID=C4Q6C8_SCHMA
Length = 587
Score = 89.4 bits (220), Expect = 1e-16
Identities = 53/149 (35%), Positives = 75/149 (50%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG VKW LEH G F P YE P Y+ + L AEEVA FYA
Sbjct: 124 WRWWEEQKKDDG-VKWKFLEHKGPLFAPPYERLPSSVHFHYDSKPIKLSDHAEEVAGFYA 182
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ KE F NFF D+ + + + + I SL KCDF + + K E+
Sbjct: 183 RMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEER 237
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K +T E+++ +E + ++ ++DG
Sbjct: 238 KNRTKEEKQKIKEENLQIQNEYGYCILDG 266
[195][TOP]
>UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni
RepID=C4Q6C7_SCHMA
Length = 652
Score = 89.4 bits (220), Expect = 1e-16
Identities = 53/149 (35%), Positives = 75/149 (50%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K DG VKW LEH G F P YE P Y+ + L AEEVA FYA
Sbjct: 124 WRWWEEQKKDDG-VKWKFLEHKGPLFAPPYERLPSSVHFHYDSKPIKLSDHAEEVAGFYA 182
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L D+ KE F NFF D+ + + + + I SL KCDF + + K E+
Sbjct: 183 RMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEER 237
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K +T E+++ +E + ++ ++DG
Sbjct: 238 KNRTKEEKQKIKEENLQIQNEYGYCILDG 266
[196][TOP]
>UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax
RepID=A5KB33_PLAVI
Length = 931
Score = 89.4 bits (220), Expect = 1e-16
Identities = 55/159 (34%), Positives = 85/159 (53%), Gaps = 7/159 (4%)
Frame = +3
Query: 69 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 245
EN + RWWE ++TD V+W LEH G+ F P Y H P+ Y+ ++L L AEE+
Sbjct: 170 ENFEPINRWWEKIDHQTD--VQWHYLEHRGLIFSPPYVQHNIPIFYKSIKLQLNEKAEEL 227
Query: 246 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 407
AT++ S + +D+ KEKF NFF F L + + L+K D S + +
Sbjct: 228 ATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDFMPI 287
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
+D K + EK +T E++E ++ +E+ +T ALVD
Sbjct: 288 KDHLVKLREEKLNRTKEEKEEEKKLRSEKELPYTYALVD 326
[197][TOP]
>UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio
RepID=UPI0001A2C88D
Length = 609
Score = 89.0 bits (219), Expect = 2e-16
Identities = 53/149 (35%), Positives = 80/149 (53%), Gaps = 3/149 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
+RWWE K + +KW LEH G YFPP Y+P Y G + L AEEVA ++A
Sbjct: 47 WRWWEE-EKYENGIKWKFLEHKGPYFPPAYQPLPDDVKFYYNGEPVKLSLPAEEVALYFA 105
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAE 437
L ++ KE FR+NFF D+R + + ++I L+KCDF + A H E +A+K
Sbjct: 106 QMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLS 164
Query: 438 KKAQTTAERKEAREAEAERVRQFTVALVD 524
K+ E+ +EA + V ++ ++D
Sbjct: 165 KE-----EKLVNKEANQKIVDEYGFCVLD 188
[198][TOP]
>UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA
Length = 560
Score = 89.0 bits (219), Expect = 2e-16
Identities = 50/145 (34%), Positives = 81/145 (55%), Gaps = 2/145 (1%)
Frame = +3
Query: 96 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 269
WE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A L
Sbjct: 1 WEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML 59
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA+ +A +K
Sbjct: 60 DHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEA-RKQM 114
Query: 450 TTAERKEAREAEAERVRQFTVALVD 524
+ E+ + +E + ++++ ++D
Sbjct: 115 SKEEKLKIKEENEKLLKEYGFCIMD 139
[199][TOP]
>UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7
Length = 839
Score = 88.2 bits (217), Expect = 3e-16
Identities = 54/159 (33%), Positives = 85/159 (53%), Gaps = 7/159 (4%)
Frame = +3
Query: 69 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 245
EN + RWWE ++TD ++W LEH G+ F P Y H P+ Y+ +++ L +EE+
Sbjct: 136 ENFEPINRWWEKIDDQTD--IQWNYLEHRGLIFSPPYVQHHVPIFYKSIKIELNAKSEEL 193
Query: 246 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 407
AT++ S + +D+ KEKF NFF F L + K T L+K D S + +
Sbjct: 194 ATYWCSAIGSDYCTKEKFILNFFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMPI 253
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
+D K + EK +T E++E ++ E+ +T ALVD
Sbjct: 254 KDHLLKLREEKLNKTKEEKEEEKKMRMEKELPYTYALVD 292
[200][TOP]
>UniRef100_Q28GG2 Novel protein similar to topoisomerase (DNA) I top1 (Fragment) n=1
Tax=Xenopus (Silurana) tropicalis RepID=Q28GG2_XENTR
Length = 335
Score = 87.8 bits (216), Expect = 4e-16
Identities = 55/152 (36%), Positives = 78/152 (51%), Gaps = 6/152 (3%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K + +T AA + + E +RWWE DG +KW LEH G F P YEP
Sbjct: 185 KAKKKTQEEKEAAAALKLKKKEEEEQMRWRWWEEEKYEDG-IKWKFLEHEGPVFAPPYEP 243
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G L L AEEVA+F+A L ++ KE FR+N+F D+R + +
Sbjct: 244 LPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LEERM 302
Query: 357 VITSLEKCDFSRI----EAHLEDEKAKKKAEK 440
VIT L KCDF+ + + +E++K K K +K
Sbjct: 303 VITDLAKCDFTEMFTYYKGKMEEKKNKSKEDK 334
[201][TOP]
>UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus
(Silurana) tropicalis RepID=Q0V9D3_XENTR
Length = 495
Score = 87.8 bits (216), Expect = 4e-16
Identities = 55/152 (36%), Positives = 78/152 (51%), Gaps = 6/152 (3%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K + +T AA + + E +RWWE DG +KW LEH G F P YEP
Sbjct: 91 KAKKKTQEEKEAAAALKLKKKEEEEQMRWRWWEEEKYEDG-IKWKFLEHEGPVFAPPYEP 149
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G L L AEEVA+F+A L ++ KE FR+N+F D+R + +
Sbjct: 150 LPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LEERM 208
Query: 357 VITSLEKCDFSRI----EAHLEDEKAKKKAEK 440
VIT L KCDF+ + + +E++K K K +K
Sbjct: 209 VITDLAKCDFTEMFTYYKGKMEEKKNKSKEDK 240
[202][TOP]
>UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1
Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO
Length = 886
Score = 87.8 bits (216), Expect = 4e-16
Identities = 52/162 (32%), Positives = 82/162 (50%), Gaps = 10/162 (6%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 248
EN + RWWE + + +W LEH G+ F P Y H P+ Y+ +++ L P AEE+A
Sbjct: 188 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELA 246
Query: 249 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 398
T++ S + TD+ K+KF NFF F L + I++ + DF I+
Sbjct: 247 TYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENENKIKNGDISNFKFIDFMTIK 306
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
HL K + E+ +T E++E ++ E+ +T ALVD
Sbjct: 307 EHL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVD 344
[203][TOP]
>UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE
Length = 966
Score = 87.8 bits (216), Expect = 4e-16
Identities = 52/149 (34%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE + DG VKW TLEH G F P YEP Y+G + L AEE+A FYA
Sbjct: 410 WKWWEEEKREDG-VKWNTLEHKGPVFAPPYEPLPDNVKFEYDGKVIKLSQDAEEIAGFYA 468
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L+ ++ K+ F NFF D+R + ++ K I L+KC+F + H + +
Sbjct: 469 RMLEHEYTSKDAFNDNFFKDWRKSMTSSEREK-IKDLKKCNFRSMHKHFAEISEANRNRT 527
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K Q A KE EA ++++ +DG
Sbjct: 528 KEQKLA-LKEQNEA---LMKEYGTCSIDG 552
[204][TOP]
>UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5F98
Length = 790
Score = 87.4 bits (215), Expect = 6e-16
Identities = 53/158 (33%), Positives = 82/158 (51%), Gaps = 2/158 (1%)
Frame = +3
Query: 3 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 182
K +D+ ++ G+ + + + ++WWE TDG KW LEH G F P YEP
Sbjct: 159 KKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPYEP 208
Query: 183 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 356
Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K
Sbjct: 209 LPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 268
Query: 357 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 470
IT L KC+F+ + +E K ++E + Q + E K+
Sbjct: 269 -ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQ 300
[205][TOP]
>UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi
RepID=Q4XMK5_PLACH
Length = 429
Score = 87.0 bits (214), Expect = 7e-16
Identities = 52/162 (32%), Positives = 82/162 (50%), Gaps = 10/162 (6%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 248
EN + RWWE + + +W LEH G+ F P Y H P+ Y+ +++ L P AEE+A
Sbjct: 163 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELA 221
Query: 249 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 398
T++ S + TD+ K+KF NFF F L + I++ + DF I+
Sbjct: 222 TYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDFMTIK 281
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
HL K + E+ +T E++E ++ E+ +T ALVD
Sbjct: 282 EHL----IKLRDERLNKTKEEKEEDKKIRMEKELPYTFALVD 319
[206][TOP]
>UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus
RepID=B0WA62_CULQU
Length = 962
Score = 87.0 bits (214), Expect = 7e-16
Identities = 51/149 (34%), Positives = 77/149 (51%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE + DG VKW LEH G F P Y+P Y+G + L EEVA FYA
Sbjct: 405 WKWWEEEKREDG-VKWNFLEHKGPVFAPPYDPLPENVKFEYDGKVMKLSQDTEEVAGFYA 463
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
++ ++ K+ F NFF D+R + ++ K I L+KC+F + A+ D K +
Sbjct: 464 RMIEHEYTSKDVFNDNFFKDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSEKNRNRS 522
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K + A KE EA V+++ + +DG
Sbjct: 523 KEEKLA-LKEQNEA---LVKEYGICNIDG 547
[207][TOP]
>UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H
RepID=B3L6G4_PLAKH
Length = 924
Score = 86.7 bits (213), Expect = 9e-16
Identities = 54/159 (33%), Positives = 83/159 (52%), Gaps = 7/159 (4%)
Frame = +3
Query: 69 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 245
EN + RWWE ++TD ++W LEH G+ F P Y H P+ Y+ ++L L AEE+
Sbjct: 170 ENFEPINRWWEKIDHQTD--IQWHYLEHRGLIFSPPYVQHHIPIFYKSIKLELNEKAEEL 227
Query: 246 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 407
AT++ S + +D+ KEKF NFF F L + L+K D S + +
Sbjct: 228 ATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDFMPI 287
Query: 408 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
+D K + EK +T E++E ++ +E+ T ALVD
Sbjct: 288 KDHLVKLREEKLNRTKEEKEEEKKLRSEKELPHTYALVD 326
[208][TOP]
>UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes
RepID=UPI00016E5FAF
Length = 573
Score = 86.3 bits (212), Expect = 1e-15
Identities = 52/138 (37%), Positives = 74/138 (53%), Gaps = 2/138 (1%)
Frame = +3
Query: 96 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 269
WE TDG KW LEH G F P YEP Y+G + L AEEVATF+A L
Sbjct: 14 WEEERSTDGS-KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKML 72
Query: 270 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
++ K+ FR NFF D+R + + +K IT L KC+F+ + +E K ++E + Q
Sbjct: 73 DHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQ 126
Query: 450 TTAERKEAREAEAERVRQ 503
+ E K+ + + ER+ Q
Sbjct: 127 MSKEEKQKIKEDNERILQ 144
[209][TOP]
>UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei
RepID=Q4YYG2_PLABE
Length = 805
Score = 86.3 bits (212), Expect = 1e-15
Identities = 52/162 (32%), Positives = 82/162 (50%), Gaps = 10/162 (6%)
Frame = +3
Query: 69 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 248
EN + RWWE + + +W LEH G+ F P Y H P+ Y+ +++ L P AEE+A
Sbjct: 133 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSVKIELNPKAEELA 191
Query: 249 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 398
T++ S + TD+ KEKF NFF F L + I++ + DF I+
Sbjct: 192 TYWCSVIGTDYCTKEKFILNFFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDFMTIK 251
Query: 399 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
+L K + E+ +T E++E ++ E+ +T ALVD
Sbjct: 252 ENL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVD 289
[210][TOP]
>UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI
Length = 638
Score = 85.1 bits (209), Expect = 3e-15
Identities = 53/149 (35%), Positives = 70/149 (46%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE N+ DG KW TLEH G F Y+ P +Y+G L EE ATFYA
Sbjct: 66 WKWWEEENRNDGN-KWLTLEHKGPVFTEPYKRLPANVRFLYDGKPFQLSKETEEAATFYA 124
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L + F NFF DFR L + K+I KC+F I + E K+ A
Sbjct: 125 KMLNHECCRNRIFYRNFFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNKRLAAT 183
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
K + A+RK+ V ++ LVDG
Sbjct: 184 KEEKLAKRKK----NEAFVNKYGFCLVDG 208
[211][TOP]
>UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA
Length = 909
Score = 84.7 bits (208), Expect = 4e-15
Identities = 49/134 (36%), Positives = 76/134 (56%), Gaps = 1/134 (0%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 308
KWTTL HNGV FPP Y+PHG ++Y+ + L EEV ++ T+++ K FR N
Sbjct: 350 KWTTLVHNGVIFPPPYKPHGVKMLYKESPVDLTLNQEEVHMIAVMQILTEYLTKPVFREN 409
Query: 309 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAE 485
D++ +L +I +L+ CDF+ I E + K EKK Q +AE K+A +E +
Sbjct: 410 VMNDWKIILGRN---HIIKNLDDCDFTPIY-----EWFRLKKEKKKQMSAEEKKAVKEEK 461
Query: 486 AERVRQFTVALVDG 527
++ ++ A+VDG
Sbjct: 462 LKQEEKYMWAVVDG 475
[212][TOP]
>UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI
Length = 557
Score = 83.2 bits (204), Expect = 1e-14
Identities = 47/132 (35%), Positives = 69/132 (52%), Gaps = 2/132 (1%)
Frame = +3
Query: 123 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 296
+VKW TLEHNG FP YE P +Y+ + L AEEVATFYA L T V +
Sbjct: 65 KVKWQTLEHNGPLFPGAYERLPENVHFLYDNCPIELTEQAEEVATFYAKVLGTPFVELSE 124
Query: 297 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 476
F NFF DFR+ L+ + TS + C+F +I +LE+++ + ++ +
Sbjct: 125 FNENFFKDFRSCLS-VEQRLHFTSFDLCNFQKIHQYLEEQQEARSQQELEEDERYGYCYI 183
Query: 477 EAEAERVRQFTV 512
+ E R+ QF +
Sbjct: 184 DGERHRINQFRI 195
[213][TOP]
>UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
adhaerens RepID=B3S6N7_TRIAD
Length = 560
Score = 81.6 bits (200), Expect = 3e-14
Identities = 55/149 (36%), Positives = 71/149 (47%), Gaps = 5/149 (3%)
Frame = +3
Query: 96 WEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL 269
WE K D VKW TLEH G P YE P Y+G L EE A FYA L
Sbjct: 1 WEEDTK-DNSVKWKTLEHKGPLLAPPYERLPSNVQFYYDGQTFPLSDKTEEAAGFYAKML 59
Query: 270 QTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKK 443
D+ K+ F NF+ DFR + A+ KV + KCDFS+I E K KAE++
Sbjct: 60 DHDYTQKKIFNDNFWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EYYKMKAEER 111
Query: 444 AQTTAERKEAREAEAERVRQ-FTVALVDG 527
+ E K + E E + Q + ++DG
Sbjct: 112 RNMSKEEKNKLKKENEELMQEYGFCIIDG 140
[214][TOP]
>UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence
n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE
Length = 725
Score = 81.6 bits (200), Expect = 3e-14
Identities = 57/163 (34%), Positives = 79/163 (48%), Gaps = 14/163 (8%)
Frame = +3
Query: 81 GGFR-----WWEAGNKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLP 227
GGF+ WWE N + E + W LEH+GV FPP Y+ H LIY G + L
Sbjct: 17 GGFQARSHNWWEEANPEESEEEEQQGQEWRYLEHHGVLFPPFYKRHNVGLIYNGKLITLT 76
Query: 228 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 407
EE+ T++A + + + KE +R NF + L TKF L+K DF++I HL
Sbjct: 77 EEQEELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIREHL 129
Query: 408 EDE---KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
E + + K E+K Q ER +R + ALVDG
Sbjct: 130 EQQRLLRLNKSDEQKKQEKLERD-------QRELFYGYALVDG 165
[215][TOP]
>UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans
RepID=O17966-2
Length = 734
Score = 81.6 bits (200), Expect = 3e-14
Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
+ WW+ K G VKW +L+H G F P Y P Y G ++ L EE+A FYA
Sbjct: 173 WEWWKEEKKPAG-VKWNSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYA 231
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE F NF D+R ++ + + I L+KCDF I+A+ +++ + +
Sbjct: 232 GVLDHEYSTKEAFNKNFMKDWRKVMT-VEERERIHDLKKCDFRAIDAYQKEQ----REIR 286
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
KA T E+ + +E + V+ + +A++DG
Sbjct: 287 KAMTKEEKLKIKEEKEAEVKIYGIAIIDG 315
[216][TOP]
>UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL
Length = 806
Score = 81.6 bits (200), Expect = 3e-14
Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 2/149 (1%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
+ WW+ K G VKW +L+H G F P Y P Y G ++ L EE+A FYA
Sbjct: 245 WEWWKEEKKPAG-VKWNSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYA 303
Query: 261 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 440
L ++ KE F NF D+R ++ + + I L+KCDF I+A+ +++ + +
Sbjct: 304 GVLDHEYSTKEAFNKNFMKDWRKVMT-VEERERIHDLKKCDFRAIDAYQKEQ----REIR 358
Query: 441 KAQTTAERKEAREAEAERVRQFTVALVDG 527
KA T E+ + +E + V+ + +A++DG
Sbjct: 359 KAMTKEEKLKIKEEKEAEVKIYGIAIIDG 387
[217][TOP]
>UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1
Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7
Length = 879
Score = 80.9 bits (198), Expect = 5e-14
Identities = 40/110 (36%), Positives = 65/110 (59%), Gaps = 2/110 (1%)
Frame = +3
Query: 126 VKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 299
VKW LEH G F P YEP + Y+G E+ L AEEVA FYA ++ D+ K+ F
Sbjct: 379 VKWMFLEHTGPLFAPPYEPLPNSVKFFYDGEEMKLSEEAEEVAGFYARMIEHDYTTKDVF 438
Query: 300 RSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 449
+NF+ D++ ++ + A +I ++KC+F +I A+ + + ++KA K +
Sbjct: 439 NNNFYRDWKKVMTHEEKA-IIKDMKKCNFKQIHAYYQRKSEERKAMSKEE 487
[218][TOP]
>UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa
FA553 RepID=UPI000187DC43
Length = 343
Score = 79.7 bits (195), Expect = 1e-13
Identities = 46/112 (41%), Positives = 64/112 (57%), Gaps = 2/112 (1%)
Frame = +3
Query: 201 YEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLE 374
++G L+LPP +EEVA FYA+ ++TDH F NFF D+ +L D I T +
Sbjct: 6 HDGKVLNLPPESEEVAGFYAALIETDHAQDAAFNKNFFEDWLKVLQDHPPCNGIKATDFD 65
Query: 375 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGR 530
KCDF + + E EKAKKKA A+ +K+ EAEA+ +F +DGR
Sbjct: 66 KCDFRPMYEYFEAEKAKKKATSAAEKKEIKKQKDEAEAKYTHRF----LDGR 113
[219][TOP]
>UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence
n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE
Length = 596
Score = 79.7 bits (195), Expect = 1e-13
Identities = 56/163 (34%), Positives = 80/163 (49%), Gaps = 14/163 (8%)
Frame = +3
Query: 81 GGFR-----WWEAGNKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLP 227
GGF+ WWE N + E + W LEH+GV FPP Y+ H LIY G + L
Sbjct: 17 GGFQARSHNWWEEANPEESEEEEQQGQEWRYLEHHGVLFPPFYKRHNVGLIYNGKLITLT 76
Query: 228 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 407
EE+ T++A + + + KE +R NF + L TKF L+K DF++I+ +L
Sbjct: 77 EEQEELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIKEYL 129
Query: 408 EDE---KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
E + + K E+K Q ER +R + ALVDG
Sbjct: 130 EQQRLLRLNKSDEQKKQEKLERD-------QRELFYGYALVDG 165
[220][TOP]
>UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
7966 RepID=A8PY85_MALGO
Length = 877
Score = 79.3 bits (194), Expect = 2e-13
Identities = 51/140 (36%), Positives = 65/140 (46%), Gaps = 4/140 (2%)
Frame = +3
Query: 120 GEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 293
GE +WTTL H G FP Y P L Y+G + LPP +EEVA FYA KL++ H
Sbjct: 118 GEQRWTTLIHKGPKFPEPYTPLPKDVMLKYDGHPVPLPPESEEVAMFYAVKLESQHASNP 177
Query: 294 KFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 467
F NFF DF L K I EK DF + + K + KK+ + RK
Sbjct: 178 IFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSMRK 237
Query: 468 EAREAEAERVRQFTVALVDG 527
A ++ + LVDG
Sbjct: 238 AELAARRAIDNEYKLCLVDG 257
[221][TOP]
>UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1
RepID=A9A2H9_NITMS
Length = 551
Score = 77.8 bits (190), Expect = 4e-13
Identities = 54/139 (38%), Positives = 76/139 (54%), Gaps = 4/139 (2%)
Frame = +3
Query: 126 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 305
+KW TL+H G+ FPP YE G + +G ++ L EE+ +A K T + + F+
Sbjct: 1 MKWKTLQHKGILFPPAYEAQGIKIKIKGEKVDLNLDQEEMIYQWAKKKDTPYAQDKVFQK 60
Query: 306 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK----KAEKKAQTTAERKEA 473
NF ADF L D+KF K+ S E DFS ++ EK K K EKKA A+RKE
Sbjct: 61 NFTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEMMTKEEKKA-IAAKRKEL 116
Query: 474 REAEAERVRQFTVALVDGR 530
RE E ++ VA++DG+
Sbjct: 117 RE---ELKSKYGVAVMDGK 132
[222][TOP]
>UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO
Length = 555
Score = 77.4 bits (189), Expect = 6e-13
Identities = 44/131 (33%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFR 302
KW TL HNG FP ++E P Y+ + L AEEVATFYA ++T V +F
Sbjct: 64 KWQTLRHNGPCFPADHERLPADVKFYYDNCPVELTEQAEEVATFYAKLMKTAFVQMREFN 123
Query: 303 SNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 482
NFF +FR+ L++ + + IT E C+F I +LE ++ +K + +
Sbjct: 124 QNFFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLECQREDEKERIAEENKLYGYCLVDG 182
Query: 483 EAERVRQFTVA 515
E+ R+ QF ++
Sbjct: 183 ESRRITQFRIS 193
[223][TOP]
>UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA
Length = 1019
Score = 75.9 bits (185), Expect = 2e-12
Identities = 49/140 (35%), Positives = 64/140 (45%), Gaps = 4/140 (2%)
Frame = +3
Query: 120 GEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 293
GE KW L H G FP Y+P L Y+G + LP EE+A FYA KL+T H
Sbjct: 159 GEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNA 218
Query: 294 KFRSNFFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 467
F NFF DF+ L + I S +K DF + + K + KKA + RK
Sbjct: 219 IFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARK 278
Query: 468 EAREAEAERVRQFTVALVDG 527
E ++ + LVDG
Sbjct: 279 REIEERKAEETKWKICLVDG 298
[224][TOP]
>UniRef100_Q3ULF5 Putative uncharacterized protein (Fragment) n=1 Tax=Mus musculus
RepID=Q3ULF5_MOUSE
Length = 291
Score = 75.1 bits (183), Expect = 3e-12
Identities = 37/82 (45%), Positives = 47/82 (57%), Gaps = 2/82 (2%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 260
++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263
Query: 261 SKLQTDHVLKEKFRSNFFADFR 326
L ++ KE FR NFF D+R
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWR 285
[225][TOP]
>UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum
RepID=A0RU10_CENSY
Length = 519
Score = 75.1 bits (183), Expect = 3e-12
Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 3/138 (2%)
Frame = +3
Query: 126 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 305
+ W TL+H+G++FPPE+E GF + +G +++L P EE+A +A K T + + F+
Sbjct: 1 MNWKTLQHSGIHFPPEHEVKGFKIKVKGKQVNLTPLQEEMAYQWAKKKDTPYAQDKVFQK 60
Query: 306 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK---KAEKKAQTTAERKEAR 476
NF DF L K + DFS ++ EK KK E+K + A+RKE R
Sbjct: 61 NFARDFAKELGIKLLYKDL------DFSEAYRLVDMEKDKKDMMTKEEKKEIAAKRKEIR 114
Query: 477 EAEAERVRQFTVALVDGR 530
E + + +A++DG+
Sbjct: 115 EGLKAK---YGIAVMDGK 129
[226][TOP]
>UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1
Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH
Length = 713
Score = 71.2 bits (173), Expect = 4e-11
Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 1/138 (0%)
Frame = +3
Query: 117 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 296
+ ++KW LEH+GV FP ++ H Y+G + L EE+AT+++ L TD K K
Sbjct: 131 NSDIKWKYLEHHGVLFPDYWQKHNVRPRYDGKPIDLNLLQEEMATYWSQTLGTDWEHKPK 190
Query: 297 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 476
+R NF F K +K DF+ I+ HLE++K +K K E K
Sbjct: 191 YRENFSKQFLDTFGKDKGK---YDFDKFDFTPIKIHLEEQKEIRKNRSK-----EEKNQE 242
Query: 477 EAEAERVRQFTV-ALVDG 527
+ + ER+ + A++DG
Sbjct: 243 KQKKERLSDYYAGAILDG 260
[227][TOP]
>UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN
Length = 240
Score = 70.9 bits (172), Expect = 5e-11
Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 2/103 (1%)
Frame = +3
Query: 129 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFR 302
KWTTL HNG F Y+ P YE + L L P AEE+AT YA + + + + F
Sbjct: 18 KWTTLSHNGPLFVDHYQALPKEVAFYYEDLPLKLNPTAEELATLYAKFMNSPLAITDTFN 77
Query: 303 SNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK 431
NFF DF++ L+ + I S E CDF++I +++ ++ ++
Sbjct: 78 ENFFKDFQSHLS-RALRRQILSFELCDFTKIAFYIQGQQGVQR 119
[228][TOP]
>UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio
RepID=UPI0001A2BD10
Length = 349
Score = 68.2 bits (165), Expect = 3e-10
Identities = 53/159 (33%), Positives = 73/159 (45%), Gaps = 12/159 (7%)
Frame = +3
Query: 87 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEG---------MELHLPPA 233
++WWE G D VKW++LEH G YF P+YE P Y+G + LH P
Sbjct: 120 WKWWEEGKSCDA-VKWSSLEHKGPYFAPDYEPLPANICFYYDGNNSERTAATLLLHSDPD 178
Query: 234 AEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED 413
T Y L FR F D + + + + K+IT+L KCDF+ I +
Sbjct: 179 LISDYTVYVCVL---------FRMFFACDCQEMTKEER--KLITTLSKCDFTHIHKYF-- 225
Query: 414 EKAKKKAEKKAQTTAERKEAREAEAER-VRQFTVALVDG 527
+K EKK T KE + EA R + +F L+DG
Sbjct: 226 --VEKAEEKKTMT----KEVLKDEAARLMEEFGYCLLDG 258
[229][TOP]
>UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis
thaliana RepID=Q8RX06_ARATH
Length = 514
Score = 63.2 bits (152), Expect = 1e-08
Identities = 39/98 (39%), Positives = 58/98 (59%), Gaps = 1/98 (1%)
Frame = +3
Query: 237 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 413
EEVAT +A +TD+ K +FR NF+ D+R LL VI L+ CDF+ I E HLE+
Sbjct: 4 EEVATMFAVMRETDYYTKPQFRENFWNDWRRLLGK---KHVIQKLDDCDFTPIYEWHLEE 60
Query: 414 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDG 527
K +KK +T E+K +E + ++ ++ A+VDG
Sbjct: 61 -----KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDG 93
[230][TOP]
>UniRef100_UPI000194EAF8 PREDICTED: similar to rCG63558, partial n=1 Tax=Taeniopygia guttata
RepID=UPI000194EAF8
Length = 79
Score = 56.6 bits (135), Expect = 1e-06
Identities = 32/85 (37%), Positives = 47/85 (55%)
Frame = +3
Query: 216 LHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI 395
+ L AEEVATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ +
Sbjct: 1 MKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHM 59
Query: 396 EAHLEDEKAKKKAEKKAQTTAERKE 470
+ K ++E + Q + E K+
Sbjct: 60 SQYF-----KAQSEARKQMSKEEKQ 79
[231][TOP]
>UniRef100_C5KK36 Putative uncharacterized protein n=1 Tax=Perkinsus marinus ATCC
50983 RepID=C5KK36_9ALVE
Length = 479
Score = 56.2 bits (134), Expect = 1e-06
Identities = 60/154 (38%), Positives = 70/154 (45%), Gaps = 2/154 (1%)
Frame = +1
Query: 55 GPPKGRMETAAFGGGKRETRRMGRSSGPLSNT-TASTFRPSMSRTGFRLSTKAWSCICLR 231
G +GR T +R TRR RSS S T S+ R S R G R + +A S R
Sbjct: 294 GGRRGRRRTRRAKSSRRRTRRRTRSSARSSRRRTRSSARSSGGRRGRRRTRRAKSSR-RR 352
Query: 232 RRKRLPPFMRPSYRRTMC*RRSSDPTSSRTSEPSWR-TPSLPR*SPAWKSVTLVGSRRT* 408
R+R R S RRT RSS S R + S R T S R + + + T RRT
Sbjct: 353 TRRRTRSSARSSRRRTRSSARSSARNSRRRTRSSRRRTRSNRRRTRSSRRRTRSSRRRT- 411
Query: 409 RMKRRRRRRRRRRRRRPSARRPVRLRPSVFVSSR 510
R RRR R RRR R S RR R S SSR
Sbjct: 412 RSSRRRTRSSRRRSARSSRRRTRRRTRSSARSSR 445
[232][TOP]
>UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio
RepID=UPI000176075D
Length = 531
Score = 55.5 bits (132), Expect = 2e-06
Identities = 37/108 (34%), Positives = 61/108 (56%), Gaps = 1/108 (0%)
Frame = +3
Query: 204 EGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCD 383
E ++L LP AEEVA ++A L ++ KE FR+NFF D+R + + ++I L+KCD
Sbjct: 11 EPVKLSLP--AEEVALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCD 67
Query: 384 FSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVD 524
F + A H E +A+K K+ E+ +EA + V ++ ++D
Sbjct: 68 FGELHAMHKEKVEARKNLSKE-----EKLVNKEANQKIVDEYGFCVLD 110
[233][TOP]
>UniRef100_B8CC90 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
RepID=B8CC90_THAPS
Length = 178
Score = 55.5 bits (132), Expect = 2e-06
Identities = 24/57 (42%), Positives = 33/57 (57%)
Frame = +3
Query: 72 NGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 242
+G ++WW GN +W +EH GV FP Y PHG ++Y+G E+ L PA EE
Sbjct: 122 HGMQAYQWWN-GNDPPKGCQWVKMEHAGVSFPEGYVPHGVKMLYDGTEVELGPAEEE 177
[234][TOP]
>UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I,
mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens
RepID=B7ZAR5_HUMAN
Length = 503
Score = 53.5 bits (127), Expect = 9e-06
Identities = 32/88 (36%), Positives = 52/88 (59%), Gaps = 1/88 (1%)
Frame = +3
Query: 267 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 446
L ++ KE FR NFF+D+R +A + +VI SL+KCDF+ I + D+ A +K
Sbjct: 2 LDHEYTTKEVFRKNFFSDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKV---- 56
Query: 447 QTTAERKEAREAEAERVRQ-FTVALVDG 527
+ E K+ + EAE+++Q F ++DG
Sbjct: 57 -LSREEKQKLKEEAEKLQQEFGYCILDG 83