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[1][TOP] >UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum RepID=TOP1_DICDI Length = 893 Score = 175 bits (444), Expect = 1e-42 Identities = 81/175 (46%), Positives = 116/175 (66%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +F+ LL + +++ ++KCDFS I HL+ +K ++KA K E K+A AE Sbjct: 371 FFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKEQRKARSK-----EEKDAETAEK 424 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 +++++ A +DG +E VGN+ +EP LFLGRG HP TG +K+RI P DVTLN+G Sbjct: 425 KKIQEKHGFATIDGFKEKVGNYMIEPPGLFLGRGQHPKTGMLKQRIMPSDVTLNIGEGEV 484 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P+PG W +I+HN+ VTWLA W++S+ GG+KYVWL+ S KG +D KFE Sbjct: 485 IPPSPIPGEKWKEIVHNNTVTWLAFWRESVNGGFKYVWLAPSSKIKGQADRKKFE 539 [2][TOP] >UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum bicolor RepID=C5YGY1_SORBI Length = 921 Score = 169 bits (429), Expect = 8e-41 Identities = 86/176 (48%), Positives = 118/176 (67%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R +L +I E CDF+ I E HL ++K +KK TT E+K RE + Sbjct: 438 FFTDWRKILGKNH---IIKKFELCDFTPIYEWHL-----REKEKKKQMTTEEKKALREEK 489 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRIQP D+T+N+G AP Sbjct: 490 LKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIQPSDITINIGKGAP 549 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 +PECP+PG +W +I H++ VTWLA W D I+ +KYV+L+A S+ KG SD K+E Sbjct: 550 VPECPIPGESWKEIKHDNTVTWLAFWNDPISQKDFKYVFLAASSSLKGQSDKEKYE 605 [3][TOP] >UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO Length = 910 Score = 167 bits (424), Expect = 3e-40 Identities = 85/175 (48%), Positives = 116/175 (66%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D++ +L VI +LE CDFS I + EK KKK TT E+K +E + Sbjct: 425 FFGDWKKILGKNH---VIQNLENCDFSPIYEWHQSEKEKKKQ----MTTEEKKALKEEKL 477 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A VDG++E VGNFRVEP LF GRG+HP GK+K+RI+P D+T+N+G +API Sbjct: 478 KQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKDAPI 537 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECPVPG W ++ H++ VTWLA W D I +KYV+L+A S KG+SD K+E Sbjct: 538 PECPVPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSTLKGLSDKEKYE 592 [4][TOP] >UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI Length = 760 Score = 167 bits (424), Expect = 3e-40 Identities = 87/182 (47%), Positives = 120/182 (65%), Gaps = 8/182 (4%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+A+L ++ AK I + KCDFS + AH E K + EKKA + AE+K Sbjct: 196 FFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDMYAHFE----KMREEKKAMSAAEKK 251 Query: 161 EAREAEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTL 337 A +AE +++ + F V L++GR+E VGNFR+EP LF GRG HP TGK+KRR+ PE +T+ Sbjct: 252 -AIKAERDKIEEPFKVCLLNGRKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEQITI 310 Query: 338 NLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAK 517 N+G P+PE P GH WG++ H++ V WLA W ++I KYV +A S+ KGMSD+ K Sbjct: 311 NIGKGVPVPE-PPAGHKWGEVRHDNSVAWLAMWHENINNSIKYVLFAANSSLKGMSDYKK 369 Query: 518 FE 523 FE Sbjct: 370 FE 371 [5][TOP] >UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q84ZL5_ORYSJ Length = 916 Score = 167 bits (423), Expect = 4e-40 Identities = 85/176 (48%), Positives = 118/176 (67%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R +L VI E CDF+ I E HL ++K +KK T+ E+K +E + Sbjct: 433 FFTDWRKILGKNH---VIKKFELCDFTPIYEWHL-----REKEKKKQMTSEEKKALKEEK 484 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRI+P D+T+N+G AP Sbjct: 485 LKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAP 544 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 IPECP+PG +W ++ H++ VTWLA W D I+ +KYV+L+A SA KG SD K+E Sbjct: 545 IPECPIPGESWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYE 600 [6][TOP] >UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=A2YRB7_ORYSI Length = 916 Score = 167 bits (423), Expect = 4e-40 Identities = 85/176 (48%), Positives = 118/176 (67%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R +L VI E CDF+ I E HL ++K +KK T+ E+K +E + Sbjct: 433 FFTDWRKILGKNH---VIKKFELCDFTPIYEWHL-----REKEKKKQMTSEEKKALKEEK 484 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRI+P D+T+N+G AP Sbjct: 485 LKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAP 544 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 IPECP+PG +W ++ H++ VTWLA W D I+ +KYV+L+A SA KG SD K+E Sbjct: 545 IPECPIPGESWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYE 600 [7][TOP] >UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B7ZWU7_MAIZE Length = 574 Score = 165 bits (418), Expect = 2e-39 Identities = 84/176 (47%), Positives = 116/176 (65%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R +L +I + E CDF+ I E HL ++K KK TT E+K RE + Sbjct: 91 FFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLREDK 142 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRI P D+T+N+G AP Sbjct: 143 LKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRILPSDITINIGKGAP 202 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 +PECP+PG +W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 203 VPECPIPGESWKEVKHDNTVTWLAFWNDPINPKDFKYVFLAASSSLKGQSDKEKYE 258 [8][TOP] >UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE Length = 904 Score = 165 bits (417), Expect = 2e-39 Identities = 84/176 (47%), Positives = 115/176 (65%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R +L +I + E CDF+ I E HL ++K KK TT E+K RE Sbjct: 421 FFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLREDN 472 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRI P D+T+N+G AP Sbjct: 473 LKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRILPSDITINIGKGAP 532 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 +PECP+PG +W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 533 VPECPIPGESWKEVKHDNTVTWLAFWNDPINPKDFKYVFLAASSSLKGQSDKEKYE 588 [9][TOP] >UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis RepID=B9SSQ1_RICCO Length = 891 Score = 164 bits (416), Expect = 3e-39 Identities = 85/175 (48%), Positives = 115/175 (65%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F+ D+R LL VI LE CDF+ I E EK KKK +T E+K +E + Sbjct: 407 FWNDWRKLLGRNH---VIQKLEDCDFTPIYEWHEREKEKKKQ----MSTEEKKAQKEEKL 459 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ A+VDG +E VGNFRVEP LF GRG+HP GK+K+RIQP D+T+N+G +API Sbjct: 460 RQEEKYMWAIVDGVKEKVGNFRVEPPALFRGRGEHPKMGKLKKRIQPSDITINIGKDAPI 519 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG +W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 520 PECPIPGESWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 574 [10][TOP] >UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XZS7_CLAL4 Length = 764 Score = 163 bits (412), Expect = 8e-39 Identities = 83/175 (47%), Positives = 111/175 (63%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L + V IT +KCDFS++ AH K + EKK + AE+ ++ Sbjct: 204 FFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF----VKVREEKKNMSKAEKLRLKQER 259 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + L++GR E VGNF+VEP +LF GRG HP TGK+K+R+ PED+TLNLG AP Sbjct: 260 EALEEPYRTCLLNGRRENVGNFKVEPPSLFRGRGAHPKTGKLKKRVYPEDITLNLGIEAP 319 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P GH WG+I H+ V WLA WK++I+ +KYV L+A S+ KG+SD KFE Sbjct: 320 IPPAP-EGHKWGEIRHDKSVVWLAMWKENISDSFKYVKLAANSSIKGISDMKKFE 373 [11][TOP] >UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum RepID=Q94705_PHYPO Length = 1015 Score = 162 bits (411), Expect = 1e-38 Identities = 82/175 (46%), Positives = 113/175 (64%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F++DFR L + KVI K DF+ I +L ++K E KA TAE K+A +AE Sbjct: 471 FWSDFRTYLTPEQ-KKVIKDFSKADFTHIHKYLVEQK-----ELKANRTAEEKKAEKAEK 524 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E++ Q + A+++G + + N+ +E LFLGRG HP TG VK+RI+ ED+T+N+G P Sbjct: 525 EKLLQKYGFAMINGHRQRISNWAIERPGLFLGRGAHPKTGLVKKRIEAEDITINIGKGVP 584 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +PE P PGH W K++H+ V WLA WK++I G+KYVWL A SA KG SD KFE Sbjct: 585 VPE-PPPGHKWCKVVHDDKVAWLAMWKENINNGFKYVWLHASSAVKGRSDMKKFE 638 [12][TOP] >UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI Length = 857 Score = 162 bits (409), Expect = 2e-38 Identities = 82/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F AD+R +L VI L+ CDF+ I ++EK KKK +T E+K +E + Sbjct: 375 FMADWRKILGKNH---VIQRLDDCDFTPIYEWHQEEKEKKKQ----MSTEEKKTLKEEKL 427 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRI P D+T+N+G N+ I Sbjct: 428 KLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIHPSDITINIGKNSQI 487 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG +W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 488 PECPIPGESWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 542 [13][TOP] >UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST Length = 780 Score = 162 bits (409), Expect = 2e-38 Identities = 86/176 (48%), Positives = 116/176 (65%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF ++ +T + V I EK DFS+I AH E K E+K T ++K+A + E Sbjct: 218 FFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE-----KLREEKKLLTKDQKKAMKEE 272 Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 ER+ + + L +G +E VGNFRVEP LF GRG HP TGK+KRR+ PE VTLN+G A Sbjct: 273 KERIEEPYKTCLFNGHKELVGNFRVEPPGLFRGRGAHPRTGKLKRRVYPEMVTLNIGAGA 332 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P PGH+WG+I +++ VTWLA W+++I +KYV +A S+ KG+SD KFE Sbjct: 333 KIPEAP-PGHSWGEIKNDNTVTWLAMWRENIADSFKYVRFAASSSIKGVSDFKKFE 387 [14][TOP] >UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP RepID=B2WCA4_PYRTR Length = 905 Score = 161 bits (407), Expect = 3e-38 Identities = 87/181 (48%), Positives = 110/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A+L T K I EKCDF I + E+AKKKA A+ A + Sbjct: 337 FFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKPIFEWFDAERAKKKALSAAEKKALKA 396 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E AEA+ + L DGR++ VGNFRVEP LF GRG+HP TG+VK+R+ PE +T+N Sbjct: 397 EKEAAEAD----YMYCLWDGRKQKVGNFRVEPPGLFRGRGEHPKTGRVKKRVMPEQITIN 452 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G NA +PE P GH W +I H+ TWLA W+++I G YKYV L+A S KG SD KF Sbjct: 453 IGENAKVPE-PPAGHRWKEIKHDHEGTWLAMWQENINGAYKYVMLAANSDIKGQSDFKKF 511 Query: 521 E 523 E Sbjct: 512 E 512 [15][TOP] >UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC Length = 852 Score = 160 bits (406), Expect = 4e-38 Identities = 81/175 (46%), Positives = 112/175 (64%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R +L VI +L+ CDF+ I EK KKK +T ++ RE + Sbjct: 394 FMNDWRKILGKNH---VIQNLDDCDFTPIYERPSSEKEKKKQ----MSTKRKRPLREEKL 446 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+KRRI+P D+T+N+G API Sbjct: 447 KQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPNDITINIGKGAPI 506 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 507 PECPIPGERWKEVRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDKEKYE 561 [16][TOP] >UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT Length = 927 Score = 160 bits (406), Expect = 4e-38 Identities = 81/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D++ +L I +LE CDF I + EK KKK TT E+K +E + Sbjct: 443 FFSDWKKMLGKNH---TIQNLEDCDFGPIYEWHQQEKEKKKQ----MTTEEKKALKEDKL 495 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+K+RI+P D+T+N+G +API Sbjct: 496 QQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPRDITINIGKDAPI 555 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ +++ VTWLA W D I +KYV+L+A S KG SD K+E Sbjct: 556 PECPIPGERWKEVRNDNTVTWLAFWIDPINQKEFKYVFLAASSTLKGQSDKEKYE 610 [17][TOP] >UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa RepID=B9I1A0_POPTR Length = 860 Score = 160 bits (405), Expect = 5e-38 Identities = 82/175 (46%), Positives = 113/175 (64%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F+ D+R LL VI LE CDF+ I + EK KKK +T E+K RE + Sbjct: 377 FWNDWRTLLGKNH---VIQKLEACDFNPIYEWHQKEKEKKKQ----MSTEEKKAVREEKL 429 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ + A+V+G +E VGNFRVEP LF GRG+HP GK+K RI+P D+T+N+G +API Sbjct: 430 KQEEMYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKSRIRPSDITINIGKDAPI 489 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 P+CP+PG W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 490 PKCPIPGERWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 544 [18][TOP] >UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJG7_9ALVE Length = 551 Score = 160 bits (405), Expect = 5e-38 Identities = 84/174 (48%), Positives = 112/174 (64%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F+ADF+A L +K IT L+ CDF I+ +L+ K+ KKA+T E++ +EA+ Sbjct: 155 FWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD----KRSEAKKARTKEEKEAEKEAKR 209 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +T +VD E VGNFRVEP NLF GRGDHP GK+K+ I PEDVT+N +AP Sbjct: 210 LNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKMGKLKQYILPEDVTVNCAADAPA 269 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P CPVPGH + ++H+ VTWLA + D+I KYV+L+A S FKG SD K+E Sbjct: 270 PRCPVPGHAYKDVVHDPAVTWLAWFTDTINNQVKYVFLNAASGFKGQSDWLKYE 323 [19][TOP] >UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5L755_9ALVE Length = 647 Score = 160 bits (405), Expect = 5e-38 Identities = 84/174 (48%), Positives = 112/174 (64%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F+ADF+A L +K IT L+ CDF I+ +L+ K+ KKA+T E++ +EA+ Sbjct: 155 FWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD----KRSEAKKARTKEEKEAEKEAKR 209 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +T +VD E VGNFRVEP NLF GRGDHP GK+K+ I PEDVT+N +AP Sbjct: 210 LNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKMGKLKQYILPEDVTVNCAADAPA 269 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P CPVPGH + ++H+ VTWLA + D+I KYV+L+A S FKG SD K+E Sbjct: 270 PRCPVPGHAYKDVVHDPAVTWLAWFTDTINNQVKYVFLNAASGFKGQSDWLKYE 323 [20][TOP] >UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG Length = 763 Score = 160 bits (405), Expect = 5e-38 Identities = 81/175 (46%), Positives = 116/175 (66%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF+DF+ ++ + A V I S +KCDFS+I H E +K+ KK+ T A+++E + + Sbjct: 202 FFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQKSLKKS----LTAAQKREIKSEK 257 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + ++ L++GR E VGNFR+EP LF GRG HP TG+VK+RI PEDV+LNL +AP Sbjct: 258 DKFEEKYKYCLLNGRRERVGNFRIEPPGLFRGRGSHPKTGRVKKRIYPEDVSLNLSEDAP 317 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P GH W +I H++ V WLA W++++T KYV +A+S+ KG SD KFE Sbjct: 318 IPP-PPEGHQWKEIKHDNTVAWLATWRENVTNTVKYVLFAADSSLKGRSDFKKFE 371 [21][TOP] >UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus RepID=A5E508_LODEL Length = 849 Score = 160 bits (405), Expect = 5e-38 Identities = 84/175 (48%), Positives = 113/175 (64%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF+ +L ++ V I EK DFS+I A+ E KK+ EKKA + E+K +E + Sbjct: 289 FFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE----KKREEKKAMSREEKKRLKEEK 344 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 F L++GR+E VGNFR+EP LF GRG HP TGK+KRR++PE VTLNL Sbjct: 345 DRIEEPFKTCLLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVRPEQVTLNLSKGVK 404 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH+W ++ H++ VTWLA WK++I+ +KYV +A S+ KG SD KFE Sbjct: 405 IPE-PPAGHHWAEVRHDNEVTWLAMWKENISDSFKYVRFAANSSVKGQSDFKKFE 458 [22][TOP] >UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe RepID=TOP1_SCHPO Length = 814 Score = 160 bits (405), Expect = 5e-38 Identities = 74/174 (42%), Positives = 110/174 (63%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DF + + F I KCDF+++ H E +K+ EKK+ ++K ++ + Sbjct: 256 FFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFE----QKREEKKSMPKEQKKAIKQKKD 311 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E ++ ++DGR+E VGNFR+EP LF GRG HP TG +KRR+ PE +T+N+G P+ Sbjct: 312 EEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHPKTGSLKRRVYPEQITINIGEGVPV 371 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P+PGH W ++ H++ VTWLA W ++I KYV+L+A S+ KG SD K+E Sbjct: 372 PE-PLPGHQWAEVKHDNTVTWLATWHENINNNVKYVFLAAGSSLKGQSDLKKYE 424 [23][TOP] >UniRef100_B8CC91 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8CC91_THAPS Length = 536 Score = 160 bits (404), Expect = 6e-38 Identities = 76/173 (43%), Positives = 111/173 (64%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR +L +I +KCDF I+ HL ++K +KA T ERK ++++ Sbjct: 16 FFTDFRTILGKNH---IIKDFKKCDFGPIQRHLNEQKLIRKAI----TDEERKVNKDSKN 68 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E + +F ALVDG E VGN+ +EP F GRG+HP GK+K+R++PE V +N+ +AP+ Sbjct: 69 ETLFKFGYALVDGHLEKVGNYNMEPPGAFRGRGEHPKMGKLKQRVEPEQVMINVSEDAPV 128 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 P C VPGH WG++ H+ V WL WK++I KY+ L+A+S+FKG SD +K+ Sbjct: 129 PMCSVPGHAWGEVRHDPTVQWLCQWKENINNQVKYMQLAAQSSFKGKSDRSKY 181 [24][TOP] >UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans RepID=Q5KB99_CRYNE Length = 881 Score = 160 bits (404), Expect = 6e-38 Identities = 87/177 (49%), Positives = 114/177 (64%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF DF+A++ K + LEKCDF + + E EK KKKA T E K+A +A Sbjct: 320 FFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKA-----LTKEEKKAIKA 374 Query: 176 EAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 E +++ + A VDGR+E VGNFR EP LF GRG+HP G VK R++PED+ +N+G Sbjct: 375 EKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIIINIGKE 434 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIP +PG W I H++ VTWLA WK+++ G KYV+LSA SA+KG SD AKFE Sbjct: 435 APIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNGNAKYVFLSAGSAWKGQSDRAKFE 490 [25][TOP] >UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans RepID=O59891_CRYNE Length = 844 Score = 160 bits (404), Expect = 6e-38 Identities = 87/177 (49%), Positives = 114/177 (64%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF DF+A++ K + LEKCDF + + E EK KKKA T E K+A +A Sbjct: 283 FFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKA-----LTKEEKKAIKA 337 Query: 176 EAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 E +++ + A VDGR+E VGNFR EP LF GRG+HP G VK R++PED+ +N+G Sbjct: 338 EKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIIINIGKE 397 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIP +PG W I H++ VTWLA WK+++ G KYV+LSA SA+KG SD AKFE Sbjct: 398 APIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNGNAKYVFLSAGSAWKGQSDRAKFE 453 [26][TOP] >UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR Length = 877 Score = 159 bits (402), Expect = 1e-37 Identities = 81/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F+ D+R LL VI L+ CDF+ I + EK KKK +T E+K +E + Sbjct: 394 FWNDWRKLLGKNH---VIQKLDDCDFNPIYEWHQQEKEKKKQ----MSTEEKKVLKEEKL 446 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+V+G +E VGNFRVEP LF GRG+HP GK+K RI+P D+T+N+G +API Sbjct: 447 KQEEKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKSRIRPSDITINIGKDAPI 506 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 507 PECPIPGERWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 561 [27][TOP] >UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT Length = 926 Score = 159 bits (401), Expect = 1e-37 Identities = 80/175 (45%), Positives = 111/175 (63%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D++ +L I +LE CDF I + EK KKK TT E+K +E Sbjct: 442 FFSDWKKILGKNH---TIQNLEDCDFGPIYEWHQQEKEKKKQ----MTTEEKKALKEERL 494 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ A+VDG +E VGNFRVEP LF GRG+HP GK+K+RI+P D+T+N+G +API Sbjct: 495 QLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRIRPRDITINIGKDAPI 554 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ +++ VTWLA W D + KYV+L+A S KG SD K+E Sbjct: 555 PECPIPGERWKEVRNDNTVTWLAYWNDPVNLKECKYVFLAASSTLKGQSDKEKYE 609 [28][TOP] >UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera RepID=UPI000198447D Length = 883 Score = 158 bits (400), Expect = 2e-37 Identities = 82/175 (46%), Positives = 110/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R L VI E CDF+ I E EK KKK TT E+K +E + Sbjct: 400 FMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKEKKKQ----MTTEEKKALKEEKL 452 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+K+RI P D+T+N+G AP+ Sbjct: 453 KQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRICPSDITINIGKEAPV 512 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 513 PECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 567 [29][TOP] >UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y3I3_PHATR Length = 594 Score = 158 bits (400), Expect = 2e-37 Identities = 79/173 (45%), Positives = 106/173 (61%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FFADFR +L K +KCDF I HL ++K +KA T ERK +E + Sbjct: 82 FFADFREILGKKHIVK---EFKKCDFEPIRKHLNEQKIIRKAI----TDEERKANKEDRS 134 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + + QF ++VDG E VGNF +EP F GRG+HP GK+K R+ PE V+LNL AP+ Sbjct: 135 QTLHQFGFSIVDGHIERVGNFNMEPPGAFRGRGEHPKMGKLKSRVLPEQVSLNLSECAPV 194 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 P CPVPGH W + H+ WLA WK++I KY+ L+A+S+FKG SD +K+ Sbjct: 195 PPCPVPGHAWSDVRHDPRGQWLATWKENINNQSKYMQLAAQSSFKGKSDRSKY 247 [30][TOP] >UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT Length = 926 Score = 158 bits (400), Expect = 2e-37 Identities = 79/175 (45%), Positives = 112/175 (64%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D++ +L + +LE CDF I + EK K+K TT E+K +E Sbjct: 442 FFSDWKKMLGKNH---TVQNLEDCDFGPIYEWHQQEKEKRKQ----MTTEEKKALKEERL 494 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+K+RI+P D+T+N+G +API Sbjct: 495 QQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPRDITINIGKDAPI 554 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ +++ VTWLA W D I KYV+L+A S KG SD K+E Sbjct: 555 PECPIPGERWKEVRNDNTVTWLAFWNDPINQKECKYVFLAASSTLKGQSDKEKYE 609 [31][TOP] >UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7PX10_VITVI Length = 789 Score = 158 bits (400), Expect = 2e-37 Identities = 82/175 (46%), Positives = 110/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R L VI E CDF+ I E EK KKK TT E+K +E + Sbjct: 306 FMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKEKKKQ----MTTEEKKALKEEKL 358 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+VDG +E VGNFRVEP LF GRG+HP GK+K+RI P D+T+N+G AP+ Sbjct: 359 KQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRICPSDITINIGKEAPV 418 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 419 PECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 473 [32][TOP] >UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UUB0_PHANO Length = 887 Score = 158 bits (400), Expect = 2e-37 Identities = 84/181 (46%), Positives = 109/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A+L T K I EKCDF I H E ++A KKA A+ A + Sbjct: 319 FFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDFKPIFEHFEADRAAKKALPAAEKKALKA 378 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E AEAE + + DGR++ VGNFRVEP LF GRG+HP TG++K+R+ PE +T+N Sbjct: 379 EKDAAEAE----YMFCMWDGRKQKVGNFRVEPPGLFRGRGEHPKTGRIKKRVAPEQITIN 434 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G NA +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD KF Sbjct: 435 IGENAKVPP-PPAGHRWKEVKHDHEGTWLAMWQENINGAYKYVMLAANSDIKGQSDFKKF 493 Query: 521 E 523 E Sbjct: 494 E 494 [33][TOP] >UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE Length = 2575 Score = 158 bits (399), Expect = 2e-37 Identities = 77/174 (44%), Positives = 114/174 (65%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+RA + + K +T ++KCDFS I +H + +KA K E+++ +EAEA Sbjct: 1930 FMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQRAEARKAASKE----EKEKRKEAEA 1984 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ AL+DGR+ T+GNFR+EP LF GRG+HP GK+K R+ PEDV +N+GP + Sbjct: 1985 KLKEEYGFALMDGRKVTIGNFRIEPPGLFQGRGEHPKMGKLKLRVMPEDVIINVGPKDKV 2044 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P GH W ++ H++ VTWLAGWK++I KY+ LSA++ KG +D K+E Sbjct: 2045 PE-PPAGHKWKEVKHDNTVTWLAGWKENIQDQNKYIMLSADTHIKGRNDWKKYE 2097 [34][TOP] >UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IDM1_CHLRE Length = 586 Score = 157 bits (398), Expect = 3e-37 Identities = 82/176 (46%), Positives = 112/176 (63%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 F+ F+ +L VI L+KCDF+ I + H+ +AKK K+ E+ ++ + Sbjct: 90 FWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQREAKKGISKE-----EKDRIKKEK 141 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+ ++ VA VDGR E VGNFRVEP LF GRG+HP GK+K+R+ P D+T+N+G N P Sbjct: 142 DEKEAKYKVAYVDGRPEPVGNFRVEPPGLFRGRGEHPKMGKIKKRVYPRDITINIGENEP 201 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523 +PE P PG W ++ H+ VTWLA WKD+I T YKYV+L A S FK SD AK+E Sbjct: 202 VPEHPYPGQTWKEVKHDHTVTWLAYWKDTISTKDYKYVFLGATSTFKADSDLAKYE 257 [35][TOP] >UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FVE9_CANGA Length = 717 Score = 157 bits (398), Expect = 3e-37 Identities = 84/177 (47%), Positives = 112/177 (63%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF+ +L D T+ I S ++ DFS + D + K EKK+ T ++KE R Sbjct: 154 FFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHDYFVQLKEEKKSMTAMQKKEIRL 209 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + ++ +DGR E VGNF+VEP +LF GRG HP TGK+KRRI+PED+ LNLG Sbjct: 210 EREKFEEKYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRIRPEDIVLNLGEG 269 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIP P GH WG+I H++ V WLA W+++I G +KYV L+A S+ KG SD KFE Sbjct: 270 APIPP-PPSGHQWGEIRHDNTVQWLAMWRENIFGSFKYVRLAANSSLKGQSDFKKFE 325 [36][TOP] >UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FTA8_NANOT Length = 896 Score = 157 bits (398), Expect = 3e-37 Identities = 82/181 (45%), Positives = 111/181 (61%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+A++ T AK + KCDF I H E K +A+KKA T AE+K Sbjct: 328 FFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVPIFEHHE----KLRAQKKAMTAAEKK 383 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 A+ + + + DGR++ VGNFRVEP LF GRG+HP TG VK R+QPE +T+N Sbjct: 384 AAKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGTVKTRVQPEQITIN 443 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +AP+P P GH W ++ H+ TWLA W++++ G YKYV L+A S KG SD+ KF Sbjct: 444 IGKDAPVP-APPEGHRWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDVKGQSDYKKF 502 Query: 521 E 523 E Sbjct: 503 E 503 [37][TOP] >UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FNH4_CANGA Length = 744 Score = 157 bits (397), Expect = 4e-37 Identities = 83/177 (46%), Positives = 114/177 (64%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF +L + T+ IT +KCDFS++ + E KK EK+ + E+K+ + Sbjct: 181 FFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFE----LKKEEKRNMSREEKKQIKL 236 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + + +F +DGR+E VGNFRVEP +LF GRG HP TGK+KRR+ PED+ LNL + Sbjct: 237 EKDKFEEKFKFCELDGRKEQVGNFRVEPPDLFRGRGAHPKTGKLKRRVYPEDIILNLSKD 296 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIP P GH+WG+I H++ V WLA WK++I G +KYV L+A S+ G SD KFE Sbjct: 297 APIPPAP-QGHHWGEIRHDNTVQWLAMWKENIFGSFKYVRLAANSSLNGQSDLKKFE 352 [38][TOP] >UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC Length = 894 Score = 157 bits (396), Expect = 5e-37 Identities = 81/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R +L VI +LE CDF+ I + EK KKK T E+K +E Sbjct: 411 FMDDWRKILGKNH---VIQNLEDCDFTPIYEWHQREKEKKKK----MTAEEKKVLKEERL 463 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++ A+V+G +E VGNFRVEP +LF GRG+HP GK+K+ I+P D+T+N+G +API Sbjct: 464 KQEEKYMWAIVNGVKEKVGNFRVEPPSLFRGRGEHPKMGKLKKCIRPSDITINIGKDAPI 523 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523 PECP+PG +W +I H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 524 PECPIPGESWKEIRHDNTVTWLAFWNDPIKPREFKYVFLAASSSLKGQSDKEKYE 578 [39][TOP] >UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N6Y9_COPC7 Length = 863 Score = 157 bits (396), Expect = 5e-37 Identities = 79/176 (44%), Positives = 112/176 (63%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF DF+ +L + IT+ E CDF + + E EKAK+KA T E+K A++ Sbjct: 319 FFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAEKAKRKA----MTNEEKKAAKKK 374 Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 + E ++ ++DGR+E VGNFR+EP LF GRG+HP G +K+R+ PED+T+N+G A Sbjct: 375 KDELEEKYKTCVMDGRKEKVGNFRIEPPGLFRGRGEHPKKGSLKKRVYPEDITINIGKEA 434 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP +PG W K+IH++ VTWLA W ++I +KYV+L+A S KG SD KFE Sbjct: 435 KIPVPNIPG-KWKKVIHDNTVTWLATWTENINNSHKYVFLAAGSRLKGQSDMQKFE 489 [40][TOP] >UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q8RX06_ARATH Length = 514 Score = 156 bits (395), Expect = 7e-37 Identities = 82/176 (46%), Positives = 115/176 (65%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 F+ D+R LL VI L+ CDF+ I E HLE+ K +KK +T E+K +E + Sbjct: 28 FWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKALKEEK 79 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E +GNFRVEP LF GRG+HP GK+K+RI P ++TLN+G AP Sbjct: 80 MKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPKMGKLKKRIHPCEITLNIGKGAP 139 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 IPECP+ G W ++ H++ VTWLA W D I +KYV+L A S+ KG+SD K+E Sbjct: 140 IPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYE 195 [41][TOP] >UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59XR0_CANAL Length = 780 Score = 156 bits (395), Expect = 7e-37 Identities = 84/175 (48%), Positives = 110/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L + V I EK DFS++ AH E K + EKKA + E+K +E + Sbjct: 220 FFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEK 275 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + + ++GR+E VGNFR+EP LF GRG HP TGK+KRR+ PE VTLNLG +A Sbjct: 276 EKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGKDAK 335 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH WG+I H++ VTWLA WK++I+ KYV + S+ KG SD KFE Sbjct: 336 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 389 [42][TOP] >UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59WV6_CANAL Length = 780 Score = 156 bits (395), Expect = 7e-37 Identities = 84/175 (48%), Positives = 110/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L + V I EK DFS++ AH E K + EKKA + E+K +E + Sbjct: 220 FFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEK 275 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + + ++GR+E VGNFR+EP LF GRG HP TGK+KRR+ PE VTLNLG +A Sbjct: 276 EKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGKDAK 335 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH WG+I H++ VTWLA WK++I+ KYV + S+ KG SD KFE Sbjct: 336 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 389 [43][TOP] >UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH Length = 916 Score = 156 bits (395), Expect = 7e-37 Identities = 82/176 (46%), Positives = 115/176 (65%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 F+ D+R LL VI L+ CDF+ I E HLE+ K +KK +T E+K +E + Sbjct: 430 FWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKALKEEK 481 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A+VDG +E +GNFRVEP LF GRG+HP GK+K+RI P ++TLN+G AP Sbjct: 482 MKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPKMGKLKKRIHPCEITLNIGKGAP 541 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 IPECP+ G W ++ H++ VTWLA W D I +KYV+L A S+ KG+SD K+E Sbjct: 542 IPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYE 597 [44][TOP] >UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36 RepID=B9WIH6_CANDC Length = 777 Score = 155 bits (393), Expect = 1e-36 Identities = 84/175 (48%), Positives = 109/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L + V I EK DFS++ AH E K + EKKA + E+K +E + Sbjct: 217 FFNDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE----KLREEKKAMSKEEKKRIKEEK 272 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + F ++GR+E VGNFR+EP LF GRG HP TGK+KRR+ PE VTLNL +A Sbjct: 273 EKEEEPFKTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVAPEQVTLNLSKDAK 332 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH WG+I H++ VTWLA WK++I+ KYV + S+ KG SD KFE Sbjct: 333 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 386 [45][TOP] >UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TJW1_VANPO Length = 799 Score = 155 bits (392), Expect = 2e-36 Identities = 81/177 (45%), Positives = 111/177 (62%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEK---CDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF+ +L + LEK CDFS++ + E ++ ++K + E+K+ R Sbjct: 236 FFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEIQRE----QRKKLSPQEKKQLRL 291 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + E+ F +DGR E VGNFRVEP +LF GRG HP TGK+KRR+ PED+ LNL N Sbjct: 292 EKEEQEEPFKFCELDGRREQVGNFRVEPPDLFRGRGAHPKTGKLKRRVYPEDIVLNLDRN 351 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIP P GH WG+I H++ V WLA W+++I+ +KYV L+A S+ KG SD KFE Sbjct: 352 APIPAVP-EGHKWGEIKHDNTVQWLAMWRENISNSFKYVRLAANSSLKGQSDFKKFE 407 [46][TOP] >UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JVV4_UNCRE Length = 889 Score = 155 bits (391), Expect = 2e-36 Identities = 82/181 (45%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A++ T AK I +KCDF I + E K+ EKKA AERK Sbjct: 339 FFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIFEYYE----MKRLEKKALPAAERK 394 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 395 RLKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKTRVQPEQITIN 454 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P PGH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 455 IGKGAAVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 513 Query: 521 E 523 E Sbjct: 514 E 514 [47][TOP] >UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QNQ2_PENMQ Length = 860 Score = 154 bits (390), Expect = 3e-36 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+A+L T AK I +KCDF I + E ++ +KK A+ A + Sbjct: 292 FFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIFEYYEGKRLEKKNLSAAEKKALKA 351 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E EAEA + + DGR++ VGNFRVEP +LF GRG+HP TGKVK R+ PE +T+N Sbjct: 352 ERDEAEAP----YMYCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKTRVMPEQITIN 407 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +A +P P GH W ++ H+ TWLA W++++ G YKYV L+A S KG SD+ KF Sbjct: 408 IGKDAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGQSDYKKF 466 Query: 521 E 523 E Sbjct: 467 E 467 [48][TOP] >UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6R590_AJECN Length = 651 Score = 154 bits (390), Expect = 3e-36 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + ++ AK + S EKCDF I + E + EKK+ +AE+K Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIFEYYE----AARLEKKSLPSAEKK 396 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 397 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 456 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P PGH W +I H+ TWLA W++++ G YKYV L+A S KG+SD+ KF Sbjct: 457 IGKEAKVP-VPPPGHKWKEIKHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGLSDYKKF 515 Query: 521 E 523 E Sbjct: 516 E 516 [49][TOP] >UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC Length = 884 Score = 154 bits (390), Expect = 3e-36 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DFR +L T AK I KCDF I A+ ++++ EKKA AE+K Sbjct: 316 FFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQPIFAYYDNQRQ----EKKALPPAEKK 371 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + + DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 372 RLKAEKDAQEAPYMFCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKSRVQPEQITIN 431 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +AP+P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 432 IGKDAPVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 490 Query: 521 E 523 E Sbjct: 491 E 491 [50][TOP] >UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH Length = 917 Score = 154 bits (389), Expect = 4e-36 Identities = 81/176 (46%), Positives = 111/176 (63%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE-AREAE 178 F+ D+R LL K SL+ CDF+ I EK KK Q TAE K +E + Sbjct: 428 FWNDWRKLLGKNHMIK---SLDDCDFTPIYEWYMQEKETKK-----QMTAEEKRIVKEEK 479 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ ++ A++DG E +GNFRVEP LF GRG+HP GK+K+RI+P D+T+N+G AP Sbjct: 480 LKQEEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKEAP 539 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 IPECP+PG W ++ H++ VTWLA W D I +KYV+L+A S+ KG SD K+E Sbjct: 540 IPECPIPGERWKEVKHDNTVTWLAFWSDPINPKEFKYVFLAASSSLKGQSDKEKYE 595 [51][TOP] >UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T3W2_PHYPA Length = 632 Score = 154 bits (389), Expect = 4e-36 Identities = 77/159 (48%), Positives = 104/159 (65%), Gaps = 1/159 (0%) Frame = +2 Query: 50 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREE 229 VI E CDF+ I D A++K KK+ +T E+K +E + ++ A+VDG +E Sbjct: 163 VIKKFELCDFTPIF----DWHAREKERKKSMSTEEKKRLKEEKLAVEEKYMWAVVDGVKE 218 Query: 230 TVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHN 409 VGNFRVEP LF GRGDHP GK+K RI P D+ +N+G +A +PECP+PG W +I H+ Sbjct: 219 KVGNFRVEPPGLFRGRGDHPKMGKLKTRILPHDIVINIGKDAAVPECPIPGQRWKEIRHD 278 Query: 410 SCVTWLAGWKDSITG-GYKYVWLSAESAFKGMSDHAKFE 523 + VTWLA WKD I +KYV+L+A S+ KG SD K+E Sbjct: 279 NTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMQKYE 317 [52][TOP] >UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA Length = 763 Score = 154 bits (389), Expect = 4e-36 Identities = 76/174 (43%), Positives = 108/174 (62%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DF+ T + E CDF+ + + E KKK EKK ++ E+K+ +E + Sbjct: 204 FFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFE----KKKEEKKNKSKEEKKKIKEEKD 259 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ +DGR+E VGNFR+EP LF GRGDHP TGK+K R+ PE V +N+G ++ I Sbjct: 260 ALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDHPKTGKLKTRVVPEQVIINIGKDSVI 319 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGHNW ++ H++ VTWLA W +++ KYV+LSA S+ KG SD K+E Sbjct: 320 PS-PPPGHNWKEVRHDNTVTWLATWNENVNNNVKYVFLSAGSSLKGQSDLKKYE 372 [53][TOP] >UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MH68_TALSN Length = 864 Score = 154 bits (389), Expect = 4e-36 Identities = 80/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+A+L T AK I KCDF I + + K+ EKKA + AE+K Sbjct: 296 FFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKPIFEYYD----AKRLEKKAMSAAEKK 351 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+QPE +T+N Sbjct: 352 ALKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPGLFRGRGEHPKTGKVKTRVQPEQITIN 411 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W++++ G YKYV L+A S KG SD+ KF Sbjct: 412 IGKEAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGQSDYKKF 470 Query: 521 E 523 E Sbjct: 471 E 471 [54][TOP] >UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri RepID=Q00XV7_OSTTA Length = 783 Score = 154 bits (388), Expect = 5e-36 Identities = 79/175 (45%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F F+ LA+ A IT KCDF+++ H AK + EKK T+ E+K + + Sbjct: 296 FMDGFKEALANGPHA-FITDFRKCDFTKMYNHF----AKIREEKKQMTSEEKKRIKAEKD 350 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + +T A +DGR E VGNFR+EP LF GRG+HP GK+KRR+ PED+T+N+G +A + Sbjct: 351 KAEEMYTWATIDGRREKVGNFRIEPPGLFRGRGEHPKMGKIKRRVMPEDITINIGKDARV 410 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH+W +IHN TWLAGW D I +KYV A S K SD K+E Sbjct: 411 PP-PPPGHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYE 464 [55][TOP] >UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HAF8_AJECH Length = 909 Score = 154 bits (388), Expect = 5e-36 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + ++ AK I S +KCDF I + E + EKK+ +AE+K Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYE----AARLEKKSLPSAEKK 396 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 397 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 456 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P PGH W ++ H+ TWLA W+++I G YKYV L+A S KG+SD+ KF Sbjct: 457 IGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGLSDYKKF 515 Query: 521 E 523 E Sbjct: 516 E 516 [56][TOP] >UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR RepID=C0NC53_AJECG Length = 909 Score = 154 bits (388), Expect = 5e-36 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + ++ AK I S +KCDF I + E + EKK+ +AE+K Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYE----AARLEKKSLPSAEKK 396 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 397 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 456 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P PGH W ++ H+ TWLA W+++I G YKYV L+A S KG+SD+ KF Sbjct: 457 IGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGLSDYKKF 515 Query: 521 E 523 E Sbjct: 516 E 516 [57][TOP] >UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023DEFB Length = 910 Score = 153 bits (387), Expect = 6e-36 Identities = 84/184 (45%), Positives = 112/184 (60%), Gaps = 10/184 (5%) Frame = +2 Query: 2 FFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKAQTTA 151 FF DF+ + D + KV I SL+KC+F +I + +E K K +++ + Sbjct: 334 FFDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEKEAAK 393 Query: 152 ERKEAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDV 331 +K+A EA FT DGR+E VGNFRVEP +LF GRG+HP TGKVK+R+QPE + Sbjct: 394 AKKDALEAP------FTHCTWDGRKEKVGNFRVEPPSLFRGRGEHPKTGKVKQRVQPEQI 447 Query: 332 TLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDH 511 T+N+G A IPE P GH W + H+ TWLA W+++I YKYV L A+SA KG SD Sbjct: 448 TINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMWQENINQNYKYVMLGADSAIKGQSDF 506 Query: 512 AKFE 523 KFE Sbjct: 507 KKFE 510 [58][TOP] >UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU Length = 909 Score = 153 bits (387), Expect = 6e-36 Identities = 84/184 (45%), Positives = 112/184 (60%), Gaps = 10/184 (5%) Frame = +2 Query: 2 FFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKAQTTA 151 FF DF+ + D + KV I SL+KC+F +I + +E K K +++ + Sbjct: 333 FFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEKEAAK 392 Query: 152 ERKEAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDV 331 +K+A EA FT DGR+E VGNFRVEP +LF GRG+HP TGKVK+R+QPE + Sbjct: 393 AKKDALEAP------FTHCTWDGRKEKVGNFRVEPPSLFRGRGEHPKTGKVKQRVQPEQI 446 Query: 332 TLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDH 511 T+N+G A IPE P GH W + H+ TWLA W+++I YKYV L A+SA KG SD Sbjct: 447 TINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMWQENINQNYKYVMLGADSAIKGQSDF 505 Query: 512 AKFE 523 KFE Sbjct: 506 KKFE 509 [59][TOP] >UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL Length = 778 Score = 153 bits (387), Expect = 6e-36 Identities = 83/175 (47%), Positives = 109/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L + V I EK DFS++ AH E K + EKKA + E+K +E + Sbjct: 218 FFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEK 273 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + + ++GR+E VGNFR+EP LF GRG HP TGK+KRR+ E VTLNLG +A Sbjct: 274 EKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVSEQVTLNLGKDAK 333 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH WG+I H++ VTWLA WK++I+ KYV + S+ KG SD KFE Sbjct: 334 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 387 [60][TOP] >UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA Length = 909 Score = 152 bits (385), Expect = 1e-35 Identities = 77/160 (48%), Positives = 109/160 (68%), Gaps = 2/160 (1%) Frame = +2 Query: 50 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGRE 226 +I +L+ CDF+ I E + K EKK Q +AE K+A +E + ++ ++ A+VDG + Sbjct: 423 IIKNLDDCDFTPIY-----EWFRLKKEKKKQMSAEEKKAVKEEKLKQEEKYMWAVVDGVK 477 Query: 227 ETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIH 406 E VGNFRVEP LF GR P GK+K+RI P D+T+N+G +APIPECP+PG +W ++ H Sbjct: 478 ENVGNFRVEPPGLFRGRESIPKMGKLKKRISPSDITINIGKDAPIPECPIPGESWKEVRH 537 Query: 407 NSCVTWLAGWKDSITG-GYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA W D I G +KYV+L+A S+ KG SD K+E Sbjct: 538 DNTVTWLAYWNDPINGKEFKYVFLAASSSLKGQSDKEKYE 577 [61][TOP] >UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA Length = 892 Score = 152 bits (385), Expect = 1e-35 Identities = 78/175 (44%), Positives = 110/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F+ D+R LL VI +L+ CDF+ I + EK KKK TT E+K +E + Sbjct: 404 FWNDWRKLLGRNH---VIQNLKDCDFTPIYDWCQSEKEKKKQ----MTTEEKKALKEEKL 456 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++ ++T A+VDG + VGNFRVEP LF GRG+HP G++K+RI P D+ +N+G A + Sbjct: 457 KQEEKYTWAIVDGVKRRVGNFRVEPPGLFRGRGEHPKMGRLKKRIHPSDIVINIGSEAQV 516 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAESAFKGMSDHAKFE 523 PECP+PG W I +++ VTWL W D I +KYV+L+A S+ KG SD K+E Sbjct: 517 PECPIPGEGWKDIRNDNTVTWLCYWSDPINPKLFKYVFLAASSSLKGQSDKEKYE 571 [62][TOP] >UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MGX0_9CHLO Length = 685 Score = 152 bits (385), Expect = 1e-35 Identities = 77/176 (43%), Positives = 110/176 (62%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 178 F+ F+ +L A I +KCDF+++ HL K++ +KKA + ++K+A+ A+ Sbjct: 223 FWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHL-----KEREKKKAISNEDKKKAKAAK 277 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++ A++DGR E VGNFRVEP LF GRG+HP G++K+RI PED+T+N+G P Sbjct: 278 DAEEEKYNWAVIDGRRERVGNFRVEPPGLFRGRGEHPKMGRIKKRIMPEDITINIGKGVP 337 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PGH W +IHN VTWL GW D+I T +KYV A S+ K SD K+E Sbjct: 338 APD-PGPGHKWKDVIHNDTVTWLCGWNDTINTKDWKYVQFGAMSSIKAESDIQKYE 392 [63][TOP] >UniRef100_A9T368 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T368_PHYPA Length = 502 Score = 152 bits (385), Expect = 1e-35 Identities = 76/160 (47%), Positives = 104/160 (65%), Gaps = 2/160 (1%) Frame = +2 Query: 50 VITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGRE 226 VI E CDF+ I + H A++K KK + E+K +E + ++ A+VDG + Sbjct: 33 VIKKFELCDFTPIFQWH-----AREKERKKNMSAEEKKRLKEEKLAAEEKYMWAVVDGVK 87 Query: 227 ETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIH 406 E VGNFRVEP LF GRGDHP GK+K RI P D+ +N+G +AP+PECP+PG W ++ H Sbjct: 88 EKVGNFRVEPPGLFRGRGDHPKMGKLKTRILPHDIVINIGKDAPVPECPIPGQKWKEVRH 147 Query: 407 NSCVTWLAGWKDSITG-GYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA WKD I +KYV+L+A S+ KG SD K+E Sbjct: 148 DNTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMLKYE 187 [64][TOP] >UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR Length = 881 Score = 152 bits (385), Expect = 1e-35 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+ +L D+K KV I KCDF I A+ + K+ EKK AE+K Sbjct: 313 FFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLPPAEKK 368 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 369 RLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKSRVQPEQITIN 428 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +AP+P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 429 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 487 Query: 521 E 523 E Sbjct: 488 E 488 [65][TOP] >UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8MY66_ASPFN Length = 881 Score = 152 bits (385), Expect = 1e-35 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+ +L D+K KV I KCDF I A+ + K+ EKK AE+K Sbjct: 313 FFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLPPAEKK 368 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 369 RLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKSRVQPEQITIN 428 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +AP+P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 429 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 487 Query: 521 E 523 E Sbjct: 488 E 488 [66][TOP] >UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium parvum Iowa II RepID=Q5CY81_CRYPV Length = 653 Score = 152 bits (384), Expect = 1e-35 Identities = 77/155 (49%), Positives = 104/155 (67%), Gaps = 2/155 (1%) Frame = +2 Query: 65 EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244 EKC+F I+ + EDEK KK K + ++K + E+ F ALVD +E VGNF Sbjct: 137 EKCNFDIIKQYFEDEKEAKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNF 192 Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCV 418 R+EP LF GRG+HP +G +KRRI PEDVTLN+ +AP+P+ P + GH W I H++ V Sbjct: 193 RIEPPGLFKGRGEHPKSGMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTV 252 Query: 419 TWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 TWLA ++DSI +KY++LSA S FKGMSD+ K+E Sbjct: 253 TWLAYYRDSINNQFKYIFLSASSGFKGMSDYNKYE 287 [67][TOP] >UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis RepID=Q5CN58_CRYHO Length = 641 Score = 152 bits (384), Expect = 1e-35 Identities = 77/155 (49%), Positives = 104/155 (67%), Gaps = 2/155 (1%) Frame = +2 Query: 65 EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244 EKC+F I+ + EDEK KK K + ++K + E+ F ALVD +E VGNF Sbjct: 125 EKCNFDIIKQYFEDEKEAKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNF 180 Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCV 418 R+EP LF GRG+HP +G +KRRI PEDVTLN+ +AP+P+ P + GH W I H++ V Sbjct: 181 RIEPPGLFKGRGEHPKSGMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTV 240 Query: 419 TWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 TWLA ++DSI +KY++LSA S FKGMSD+ K+E Sbjct: 241 TWLAYYRDSINNQFKYIFLSASSGFKGMSDYNKYE 275 [68][TOP] >UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HDT9_CHAGB Length = 907 Score = 151 bits (382), Expect = 2e-35 Identities = 81/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FFADF+ +L T AK I +K DF++I H + +KA A+ AE+ Sbjct: 335 FFADFKDILKKTGGAKDKQGKPVDIKEFKKLDFTKIFDHYKALGDARKARPAAEKKAEKA 394 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E +AE F DGR+E VGNFRVEP LF GRG+HP TG VK+R+ PE VT+N Sbjct: 395 EKDKAEGH----FMFCKWDGRKEKVGNFRVEPPGLFRGRGEHPKTGTVKKRVMPEQVTIN 450 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +A +P P PGH W + H++ TWLA W++++ G YKYV L+A S KG +D KF Sbjct: 451 IGKDAKVP-APPPGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSTVKGQADFKKF 509 Query: 521 E 523 E Sbjct: 510 E 510 [69][TOP] >UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735 delta SOWgp RepID=C5P0Y8_COCP7 Length = 905 Score = 151 bits (382), Expect = 2e-35 Identities = 81/181 (44%), Positives = 107/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A++ T AK +I +KCDF I + E K+ EKKA AERK Sbjct: 337 FFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE----MKREEKKALPAAERK 392 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 393 RLKVEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKTRVQPEQITIN 452 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD KF Sbjct: 453 IGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDFKKF 511 Query: 521 E 523 E Sbjct: 512 E 512 [70][TOP] >UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis RepID=Q1DXZ1_COCIM Length = 905 Score = 151 bits (381), Expect = 3e-35 Identities = 81/181 (44%), Positives = 107/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A++ T AK +I +KCDF I + E K+ EKKA AERK Sbjct: 337 FFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE----MKREEKKALPAAERK 392 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 393 RLKAEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKIRVQPEQITIN 452 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD KF Sbjct: 453 IGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDFKKF 511 Query: 521 E 523 E Sbjct: 512 E 512 [71][TOP] >UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEP3_LACTC Length = 756 Score = 151 bits (381), Expect = 3e-35 Identities = 81/178 (45%), Positives = 111/178 (62%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF +L + K I E CDFS++ + + +K +KK Q +++ K+ + Sbjct: 193 FFNDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQLQKEQKK-----QLSSQEKKKLK 247 Query: 173 AEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 E E+ + F +DGR+E VGNFR+EP LF GRG HP TGK+KRR+ PEDV LNL Sbjct: 248 IEKEQFEEPFKFCFLDGRKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVYPEDVVLNLDK 307 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A IP+ P GH WG+I H+S V WLA W+++I+ +KYV +A S+ KGMSD KFE Sbjct: 308 EAEIPKAP-EGHKWGEIRHDSTVQWLAMWRENISNSFKYVRFAANSSLKGMSDFKKFE 364 [72][TOP] >UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1D4R5_NEOFI Length = 886 Score = 151 bits (381), Expect = 3e-35 Identities = 81/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+ +L T AK I KCDF I + E K+ EKK AE+K Sbjct: 318 FFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYE----AKRIEKKNLPPAEKK 373 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + L DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 374 RLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQPEQITIN 433 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +AP+P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG+SD+ KF Sbjct: 434 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGLSDYKKF 492 Query: 521 E 523 E Sbjct: 493 E 493 [73][TOP] >UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL Length = 886 Score = 151 bits (381), Expect = 3e-35 Identities = 80/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF+DF+ +L T AK I KCDF I A+ + K+ EK+ AE+K Sbjct: 318 FFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQSIFAYYD----AKRIEKRNIPPAEKK 373 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + L DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 374 RLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 433 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G AP+P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD KF Sbjct: 434 IGKGAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDFKKF 492 Query: 521 E 523 E Sbjct: 493 E 493 [74][TOP] >UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404 RepID=C5M985_CANTT Length = 777 Score = 150 bits (379), Expect = 5e-35 Identities = 81/175 (46%), Positives = 109/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L + V I EK DFS++ A+ E ++ EKKA + E+K +E Sbjct: 217 FFNDFLEVLKECGGCGVEIKEFEKMDFSKMYAYYEQQRE----EKKALSRDEKKRLKEER 272 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + + ++GR+E VGNFR+EP LF GRG HP TGK+KRR+ PE VTLNLG +A Sbjct: 273 DKFEEPYKTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVAPEQVTLNLGKDAK 332 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +PE P GH WG+I H++ VTWLA WK++I+ KYV + S+ KG SD KFE Sbjct: 333 VPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSTKYVRFANNSSIKGQSDFKKFE 386 [75][TOP] >UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7EXF7_SCLS1 Length = 911 Score = 150 bits (379), Expect = 5e-35 Identities = 80/181 (44%), Positives = 107/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF + T AK I K DF I + + K E+KA++ AE+K Sbjct: 339 FFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIFEYYDG----KSTERKARSAAEKK 394 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + A+ E + + DGR+E VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 395 AEKAAKDEAEAPYKTCIWDGRKEDVGNFRVEPPGLFRGRGEHPKTGKVKLRVTPEQITIN 454 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W I H++ TWLA W+++I G YKYV L+A+S+ KG SD+ KF Sbjct: 455 IGKEATVPS-PPEGHKWKAIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDYKKF 513 Query: 521 E 523 E Sbjct: 514 E 514 [76][TOP] >UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66 RepID=B6ABX7_9CRYT Length = 660 Score = 150 bits (378), Expect = 7e-35 Identities = 74/155 (47%), Positives = 105/155 (67%), Gaps = 2/155 (1%) Frame = +2 Query: 65 EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244 +KCDFS I+ H ++EK +KK K Q +++ E+E+ + ALVD +E VGNF Sbjct: 133 DKCDFSLIKEHFDEEKERKKNMNKEQKEQQKRIKNESESP----YIYALVDWIKEKVGNF 188 Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIP--ECPVPGHNWGKIIHNSCV 418 R+EP LF GRG+HP +G +K+RI E+VTLN+ +AP+P + + GH W + H+S V Sbjct: 189 RIEPPGLFRGRGEHPKSGMLKKRIFSEEVTLNVAEDAPVPKVDSSIIGHAWKDVFHDSNV 248 Query: 419 TWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 TWLA +KDSI +KY++LSA S FKGMSD+ K+E Sbjct: 249 TWLAYYKDSINNQFKYIFLSASSGFKGMSDYNKYE 283 [77][TOP] >UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SIQ6_9PEZI Length = 891 Score = 150 bits (378), Expect = 7e-35 Identities = 75/177 (42%), Positives = 112/177 (63%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFA--KVITSLEKCDFSRIEAH-LEDEKAKKKAEKKAQTTAERKEARE 172 FF DFR ++ + A K ++ DF +I + D ++ A +K +T E+K+ +E Sbjct: 320 FFEDFREVIKEHGSATDKDGKKVDIKDFHKINWQPMADYAEQQSAMRKNRTKEEKKQIKE 379 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + R F L DGR+E +GNFRVEP +LF GRGDHP TG++K+++ PE +T+N+G + Sbjct: 380 EKDAREEPFKYCLWDGRKEKMGNFRVEPPSLFRGRGDHPKTGRIKKQVFPEQITINIGKD 439 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A IP+ P GH W ++H++ TWLA W+++I G YKYV + S+ KG SDH KFE Sbjct: 440 AKIPK-PPDGHKWKAVVHDNKATWLASWQENINGAYKYVMTGSSSSVKGKSDHMKFE 495 [78][TOP] >UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2 Tax=Emericella nidulans RepID=C8VUK1_EMENI Length = 871 Score = 150 bits (378), Expect = 7e-35 Identities = 79/181 (43%), Positives = 109/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FFADF+ +L T AK I KCDF I + + ++ EKKA AE+K Sbjct: 303 FFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQRQ----EKKALPPAEKK 358 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 359 RLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 418 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 419 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 477 Query: 521 E 523 E Sbjct: 478 E 478 [79][TOP] >UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC Length = 998 Score = 150 bits (378), Expect = 7e-35 Identities = 80/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+ +L T AK I KCDF I + + K+ EKK AE+K Sbjct: 430 FFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYD----AKRIEKKNLPPAEKK 485 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + L DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 486 RLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQPEQITIN 545 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +AP+P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG+SD+ KF Sbjct: 546 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGLSDYKKF 604 Query: 521 E 523 E Sbjct: 605 E 605 [80][TOP] >UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC 6260 RepID=UPI000151AE34 Length = 754 Score = 149 bits (377), Expect = 9e-35 Identities = 76/175 (43%), Positives = 109/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 F+ DF ++ ++ A V + K DF+++ AH E K +KK + E+K +EA+ Sbjct: 194 FWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE----MLKEQKKNMSRDEKKALKEAK 249 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + + L++GR+E VGNFRVEP LF GRG HP TGK+K+R+ PED+TLNL Sbjct: 250 EKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPKTGKLKKRVYPEDITLNLSKECK 309 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +PE P GH WG++ H++ V WLA WK++I+ KYV +A S+ KG SD KFE Sbjct: 310 VPE-PPAGHKWGEVRHDNTVAWLAMWKENISDSLKYVRFAANSSVKGQSDFKKFE 363 [81][TOP] >UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO Length = 732 Score = 149 bits (377), Expect = 9e-35 Identities = 77/177 (43%), Positives = 113/177 (63%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKV---ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF ++L A+ I KCDFS++ A+++ ++ + K ++ ERK ++ Sbjct: 169 FFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQQRV----QMKQLSSHERKLLKQ 224 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + + V L+ GR+E V F+++P +LF GRG HP TGK+KRR+QPEDV LNL + Sbjct: 225 EKGQTEGPVQVLLLTGRKEQVDTFKIDPPDLFRGRGAHPKTGKLKRRVQPEDVVLNLDKD 284 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIPE P GH WG+I H++ V WL W+++I+ +KYV L+A S+ KGMSD KFE Sbjct: 285 APIPE-PPAGHKWGEIRHDNTVQWLCMWRENISNSFKYVRLAANSSLKGMSDFKKFE 340 [82][TOP] >UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YQG7_NECH7 Length = 919 Score = 149 bits (377), Expect = 9e-35 Identities = 83/181 (45%), Positives = 109/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 163 FF DF+ + D KV I SL+KCDF+++ + AK + K T E KE Sbjct: 343 FFEDFQEYCKKYGVTDADGKKVQIKSLDKCDFTKLADYW---LAKAEQNKTKNMTKEEKE 399 Query: 164 AREAEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 A +A+ E + FT + DGR++ VGNFRVEP +LF GRG+HP TGKVK R+ PE +T+N Sbjct: 400 AAKAKKEALEAPFTHCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKNRVTPEQITIN 459 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A IP+ P GH W + H+ TWLA W+++I YKYV L A S KG SD KF Sbjct: 460 IGKGAKIPD-PPKGHQWKAVQHDQKATWLAMWQENINNNYKYVMLGAASDIKGQSDFKKF 518 Query: 521 E 523 E Sbjct: 519 E 519 [83][TOP] >UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii RepID=A5DLX4_PICGU Length = 754 Score = 149 bits (377), Expect = 9e-35 Identities = 76/175 (43%), Positives = 109/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 F+ DF ++ ++ A V + K DF+++ AH E K +KK + E+K +EA+ Sbjct: 194 FWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE----MLKEQKKNMSRDEKKALKEAK 249 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + + L++GR+E VGNFRVEP LF GRG HP TGK+K+R+ PED+TLNL Sbjct: 250 EKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPKTGKLKKRVYPEDITLNLSKECK 309 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +PE P GH WG++ H++ V WLA WK++I+ KYV +A S+ KG SD KFE Sbjct: 310 VPE-PPAGHKWGEVRHDNTVAWLAMWKENISDSLKYVRFAANSSVKGQSDFKKFE 363 [84][TOP] >UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BE191 Length = 789 Score = 149 bits (376), Expect = 1e-34 Identities = 79/176 (44%), Positives = 109/176 (61%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L D V I + DFS++ AH E + +KK K + K+A +AE Sbjct: 229 FFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAE 283 Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 ++ + + L++G +E VGNFR+EP LF GRG HP TGK+KRR+ PEDVTLNL Sbjct: 284 KDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEDVTLNLSEGC 343 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ H++ V+WLA WK++I +KYV +A S+ KG+SD KFE Sbjct: 344 KIPE-PPQGHKWAEVRHDNTVSWLAMWKENIADSFKYVRFAANSSIKGLSDFKKFE 398 [85][TOP] >UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA Length = 789 Score = 149 bits (376), Expect = 1e-34 Identities = 79/176 (44%), Positives = 109/176 (61%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF DF +L D V I + DFS++ AH E + +KK K + K+A +AE Sbjct: 229 FFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAE 283 Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 ++ + + L++G +E VGNFR+EP LF GRG HP TGK+KRR+ PEDVTLNL Sbjct: 284 KDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEDVTLNLSEGC 343 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ H++ V+WLA WK++I +KYV +A S+ KG+SD KFE Sbjct: 344 KIPE-PPQGHKWAEVRHDNTVSWLAMWKENIADSFKYVRFAANSSIKGLSDFKKFE 398 [86][TOP] >UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CUT4_ASPTN Length = 872 Score = 149 bits (376), Expect = 1e-34 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+ +L D K KV I +KCDF I + E K+ EK+ AE+K Sbjct: 304 FFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIFDYYE----AKRIEKRNLPAAEKK 359 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E+ + + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 360 RLKAEKDEQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 419 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 420 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 478 Query: 521 E 523 E Sbjct: 479 E 479 [87][TOP] >UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis RepID=C5GB81_AJEDR Length = 911 Score = 149 bits (376), Expect = 1e-34 Identities = 79/181 (43%), Positives = 106/181 (58%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + + AK I S + CDF I + E + EKK AE+K Sbjct: 343 FFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKPIFEYYE----AARLEKKNLPAAEKK 398 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 399 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 458 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +A +P P PGH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 459 IGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 517 Query: 521 E 523 E Sbjct: 518 E 518 [88][TOP] >UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI Length = 871 Score = 149 bits (375), Expect = 1e-34 Identities = 79/181 (43%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FFADF+ +L T AK I KCDF I + + ++ EKKA AE+K Sbjct: 303 FFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQRQ----EKKALPPAEKK 358 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + + DGR++ VGNFRVEP LF GRG+HP TG+VK R+QPE +T+N Sbjct: 359 RLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPPLFRGRGEHPKTGRVKARVQPEQITIN 418 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 419 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 477 Query: 521 E 523 E Sbjct: 478 E 478 [89][TOP] >UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6H1W4_PENCW Length = 864 Score = 149 bits (375), Expect = 1e-34 Identities = 79/181 (43%), Positives = 112/181 (61%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLA------DTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF+DF+ ++ D+K KV I KCDF I + ++ EK+ AE+K Sbjct: 295 FFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIFEFYDAQRE----EKRHLPPAEKK 350 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 A+ + E+ + + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 351 AAKALKDEQEAPYQYCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKTRVQPEQITIN 410 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +A +P P PGH W ++ H+ TWLA W+++I G YKYV L+A S KG SD KF Sbjct: 411 IGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDFKKF 469 Query: 521 E 523 E Sbjct: 470 E 470 [90][TOP] >UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01 RepID=C1H484_PARBA Length = 900 Score = 148 bits (373), Expect = 3e-34 Identities = 80/181 (44%), Positives = 105/181 (58%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + + AK I S +KCDF I E + EKKA AE+K Sbjct: 332 FFNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKPIFEFYE----AARLEKKALPAAEKK 387 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 388 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 447 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 448 IGKEAKVP-TPPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 506 Query: 521 E 523 E Sbjct: 507 E 507 [91][TOP] >UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana B05.10 RepID=A6S3Q9_BOTFB Length = 912 Score = 148 bits (373), Expect = 3e-34 Identities = 80/181 (44%), Positives = 106/181 (58%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF + T AK I K DF I + + + ++KA A+ AE+ Sbjct: 340 FFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIFEYYDGKSTERKARSAAEKKAEKA 399 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 EAEA + + DGR+E VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 400 LKDEAEAP----YKTCIWDGRKEDVGNFRVEPPGLFRGRGEHPKTGKVKLRVTPEQITIN 455 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G +A +P P GH W I H++ TWLA W+++I G YKYV L+A+S+ KG SD KF Sbjct: 456 IGKDATVPS-PPEGHKWKAIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDFKKF 514 Query: 521 E 523 E Sbjct: 515 E 515 [92][TOP] >UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina RepID=B2AY06_PODAN Length = 904 Score = 147 bits (372), Expect = 3e-34 Identities = 79/181 (43%), Positives = 107/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DFR +L +T AK I K DF++I + + KKA A+ AE+ Sbjct: 332 FFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIFEYYKGLSEAKKARPAAEKKAEKA 391 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E + EA + DGR+E VGNFRVEP LF GRG+HP TG VK+R+ PE VT+N Sbjct: 392 EKDKFEAP----YMYCKWDGRKEKVGNFRVEPPGLFRGRGEHPKTGTVKKRVMPEQVTIN 447 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P+ P GH W + H++ TWLA W++++ G YKYV L+A S KG +D+ KF Sbjct: 448 IGKEAKVPD-PPAGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSTVKGQADYKKF 506 Query: 521 E 523 E Sbjct: 507 E 507 [93][TOP] >UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera RepID=UPI0000DB758E Length = 973 Score = 147 bits (371), Expect = 4e-34 Identities = 69/174 (39%), Positives = 109/174 (62%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R ++ +++ K++ L KC+F I A+ +K E+KA T E+++ +E Sbjct: 504 FFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----IQKSEERKAMTKEEKQKIKEKNE 558 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E +++ ++DG +E +GNF++EP LF GRG+HP GK+K+R+ PED+ +N ++ I Sbjct: 559 EIQKEYGYCIIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRVMPEDILINCSKDSNI 618 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PGH W +I H+ VTWLA W ++I G KYV L+ S KG D K+E Sbjct: 619 PK-PPPGHKWKEIRHDPNVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYE 671 [94][TOP] >UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187DC43 Length = 343 Score = 147 bits (370), Expect = 6e-34 Identities = 82/176 (46%), Positives = 109/176 (61%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVI--TSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF D+ +L D I T +KCDF + + E EKAKKKA A+ +K+ EA Sbjct: 42 FFEDWLKVLQDHPPCNGIKATDFDKCDFRPMYEYFEAEKAKKKATSAAEKKEIKKQKDEA 101 Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 EA+ +F +DGR+E VGNFRVEP LF GRG+HP G +K R+ PED+ LN+G +A Sbjct: 102 EAKYTHRF----LDGRKEKVGNFRVEPPGLFRGRGEHPKKGSLKYRVCPEDIALNIGKDA 157 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P +PG W I H++ VTWLA ++I +KYV+L+A S+ KG SD AKFE Sbjct: 158 PTPIPNIPG-KWKAIQHDNTVTWLATRTENINQSHKYVFLAAGSSLKGRSDMAKFE 212 [95][TOP] >UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DTW1_TRYCR Length = 664 Score = 147 bits (370), Expect = 6e-34 Identities = 80/176 (45%), Positives = 108/176 (61%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF+ +R +L K I LE CDF I + HL + EKK T E K+ E Sbjct: 108 FFSSWREIL--DKRQHPIRRLELCDFEPIYQWHLRER------EKKLSRTKEEKKQLRLE 159 Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 AE+ + + + DG++E V NFRVEP LF GRG HP+ GK+K+R++PED+T+N+ + Sbjct: 160 AEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHPMMGKLKKRVEPEDITINIDEFS 219 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PIP+ P GH W +++H VTWLA W+DSI G +KYV L+ SA KG SD KFE Sbjct: 220 PIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILGSFKYVMLAPSSAIKGQSDMLKFE 274 [96][TOP] >UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI Length = 871 Score = 147 bits (370), Expect = 6e-34 Identities = 78/181 (43%), Positives = 108/181 (59%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FFADF+ +L T AK I KCD I + + ++ EKKA AE+K Sbjct: 303 FFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIFQYYDAQRQ----EKKALPPAEKK 358 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + + + + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N Sbjct: 359 RLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 418 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 419 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 477 Query: 521 E 523 E Sbjct: 478 E 478 [97][TOP] >UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2 Length = 745 Score = 146 bits (369), Expect = 7e-34 Identities = 75/177 (42%), Positives = 109/177 (61%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF +L ++ I +CDF+++ + + +K +KK T+ E+K+ R Sbjct: 182 FFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ----LQKEQKKQLTSQEKKQIRL 237 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + + +DGR E VGNF+VEP +LF GRG HP TGK+KRR+ PED+ LNL + Sbjct: 238 EREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKD 297 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 AP+P P GH WG+I H++ V WLA W+++I +KYV L+A S+ KG SD+ KFE Sbjct: 298 APVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFE 353 [98][TOP] >UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18 RepID=C1GKM6_PARBD Length = 825 Score = 146 bits (369), Expect = 7e-34 Identities = 79/181 (43%), Positives = 104/181 (57%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + + AK I S +KCDF I E + EKKA E+K Sbjct: 337 FFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIFEFYE----AARLEKKALPATEKK 392 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 393 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 452 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 453 IGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 511 Query: 521 E 523 E Sbjct: 512 E 512 [99][TOP] >UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03 RepID=C0SEQ3_PARBP Length = 905 Score = 146 bits (369), Expect = 7e-34 Identities = 79/181 (43%), Positives = 104/181 (57%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF A + + AK I S +KCDF I E + EKKA E+K Sbjct: 337 FFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIFEFYE----AARLEKKALPATEKK 392 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 + + E + + DGR++ VGNFRVEP LF GRG+HP TGKVK R+ PE +T+N Sbjct: 393 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 452 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +P P GH W ++ H+ TWLA W+++I G YKYV L+A S KG SD+ KF Sbjct: 453 IGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 511 Query: 521 E 523 E Sbjct: 512 E 512 [100][TOP] >UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae RepID=B3LJ50_YEAS1 Length = 769 Score = 146 bits (369), Expect = 7e-34 Identities = 75/177 (42%), Positives = 109/177 (61%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF +L ++ I +CDF+++ + + +K +KK T+ E+K+ R Sbjct: 206 FFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ----LQKEQKKQLTSQEKKQIRL 261 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + + +DGR E VGNF+VEP +LF GRG HP TGK+KRR+ PED+ LNL + Sbjct: 262 EREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKD 321 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 AP+P P GH WG+I H++ V WLA W+++I +KYV L+A S+ KG SD+ KFE Sbjct: 322 APVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFE 377 [101][TOP] >UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae RepID=TOP1_YEAST Length = 769 Score = 146 bits (369), Expect = 7e-34 Identities = 75/177 (42%), Positives = 109/177 (61%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF +L ++ I +CDF+++ + + +K +KK T+ E+K+ R Sbjct: 206 FFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ----LQKEQKKQLTSQEKKQIRL 261 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + + +DGR E VGNF+VEP +LF GRG HP TGK+KRR+ PED+ LNL + Sbjct: 262 EREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKD 321 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 AP+P P GH WG+I H++ V WLA W+++I +KYV L+A S+ KG SD+ KFE Sbjct: 322 APVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFE 377 [102][TOP] >UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei RepID=Q581U8_9TRYP Length = 661 Score = 146 bits (368), Expect = 1e-33 Identities = 78/174 (44%), Positives = 103/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +R +L K I LE CDFS I + E K+K+ +T E+KE + Sbjct: 133 FFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVEKRKS----RTREEKKELKRIAD 186 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E + + +G++E V NFRVEP LF GRG+HP+ GK+K+RI PEDV LN+G API Sbjct: 187 EEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMRGKLKKRILPEDVVLNIGKEAPI 246 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W ++H+ VTWLA W + G KYV L+ S KG SD+AKFE Sbjct: 247 PQAPA-GHKWKGVVHDQNVTWLAMWYEPTIGQCKYVMLAPSSTLKGQSDYAKFE 299 [103][TOP] >UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma brucei RepID=C9ZLY6_TRYBG Length = 696 Score = 146 bits (368), Expect = 1e-33 Identities = 78/174 (44%), Positives = 103/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +R +L K I LE CDFS I + E K+K+ +T E+KE + Sbjct: 168 FFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVEKRKS----RTREEKKELKRIAD 221 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E + + +G++E V NFRVEP LF GRG+HP+ GK+K+RI PEDV LN+G API Sbjct: 222 EEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMRGKLKKRILPEDVVLNIGKEAPI 281 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W ++H+ VTWLA W + G KYV L+ S KG SD+AKFE Sbjct: 282 PQAPA-GHKWKGVVHDQNVTWLAMWYEPTIGQCKYVMLAPSSTLKGQSDYAKFE 334 [104][TOP] >UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R0K7_MAGGR Length = 906 Score = 146 bits (368), Expect = 1e-33 Identities = 82/181 (45%), Positives = 104/181 (57%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF F+ L T AK I EK DF I H + + KKA K + AE K Sbjct: 333 FFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIFQHFQAQSEAKKARSKEEKKAE-K 391 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 EAR+ E + DGR+E VGNFRVEP LF GRG+HP TG +K R+ PE VT+N Sbjct: 392 EARDKMEE---PYKYCKWDGRKEKVGNFRVEPPALFRGRGEHPKTGTIKERVPPEAVTIN 448 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +PE P GH W + H++ TWLA W++++ G YKYV L+A SA KG +D KF Sbjct: 449 IGKGAKVPE-PPAGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSAVKGQADFKKF 507 Query: 521 E 523 E Sbjct: 508 E 508 [105][TOP] >UniRef100_A4S5R8 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901 RepID=A4S5R8_OSTLU Length = 491 Score = 145 bits (367), Expect = 1e-33 Identities = 78/175 (44%), Positives = 102/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F F+A L + A IT KCDF+++ H + KKK T+ E+K + + Sbjct: 16 FMDGFKAALKNGPHA-FITDFSKCDFTKMYMHFLAIREKKKE----MTSEEKKRIKAQKD 70 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +T A +DGR E VGNFRVEP LF GRG+HP GK+KRR+ PED+T+N+G +A + Sbjct: 71 IDEEPYTWATIDGRREKVGNFRVEPPGLFRGRGEHPKMGKIKRRVVPEDITINIGKDAKV 130 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523 PE P GH+W +IHN TWLAGW D I +KYV A S K SD K+E Sbjct: 131 PE-PPAGHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYE 184 [106][TOP] >UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR Length = 664 Score = 145 bits (367), Expect = 1e-33 Identities = 79/176 (44%), Positives = 108/176 (61%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF+ +R +L + I LE CDF I + HL + EKK T E K+ E Sbjct: 108 FFSSWREILDRRQHP--IRRLELCDFEPIYQWHLRER------EKKLSRTKEEKKQLRLE 159 Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 AE+ + + + DG++E V NFRVEP LF GRG HP+ GK+K+R++PED+T+N+ + Sbjct: 160 AEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHPMMGKLKKRVEPEDITINIDEFS 219 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PIP+ P GH W +++H VTWLA W+DSI G +KYV L+ SA KG SD KFE Sbjct: 220 PIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILGSFKYVMLAPSSAIKGQSDMLKFE 274 [107][TOP] >UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi RepID=A8Q2Z1_BRUMA Length = 751 Score = 144 bits (364), Expect = 3e-33 Identities = 68/174 (39%), Positives = 107/174 (61%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R ++ + K IT L KCDF + H K + E+++ + E+++ +E + Sbjct: 274 FFTDWRKVMTPAEREK-ITDLTKCDFREMHDHY----IKLREERRSLSKEEKQKLKEIKQ 328 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E + + VA +DG ++ +GNFR+EP +LF GRG HP G++K+R+ PEDV +N ++ I Sbjct: 329 EEAKIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHPKMGRLKKRVNPEDVIINCSKDSEI 388 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W ++ H++ VTWL W D+I G KY+ L+ S KG D+ KFE Sbjct: 389 PK-PPEGHRWKEVRHDNTVTWLCSWTDNILGSIKYIMLNPSSKIKGEKDYEKFE 441 [108][TOP] >UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299 RepID=C1FD86_9CHLO Length = 635 Score = 144 bits (363), Expect = 4e-33 Identities = 75/161 (46%), Positives = 102/161 (63%), Gaps = 4/161 (2%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKK---AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 223 I +KCDF++I E+ +KK AE+K + AE+ A E ++ A +DGR Sbjct: 187 IKDFKKCDFTKIYMWNLQERERKKSVSAEEKRKVKAEQAAAEE-------KYCWATIDGR 239 Query: 224 EETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKII 403 E VGN++VEP LF GRG+HP G+VK+RI PED+ +N+G A +PE P+PGH W +II Sbjct: 240 RERVGNYKVEPPGLFRGRGEHPKMGRVKKRIMPEDIIINIGKGAKVPE-PLPGHKWKQII 298 Query: 404 HNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523 HN+ VTWL GW D+I T +KYV A S+ K SD K+E Sbjct: 299 HNNTVTWLCGWNDTINTKDWKYVQFGATSSIKAESDIQKYE 339 [109][TOP] >UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum RepID=Q9Y180_LEIIN Length = 635 Score = 144 bits (363), Expect = 4e-33 Identities = 85/178 (47%), Positives = 106/178 (59%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---EDEKAKKKAEKKAQTTAERKEAR 169 FF +R +L K I LE CDF I + HL E + ++ K EKKA KE + Sbjct: 105 FFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAI-----KEKQ 157 Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 +AEAE R + DGR E V NFRVEP LF GRG HPL GK+K R+QPED+T+N+G Sbjct: 158 DAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGE 214 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A +P P GH W + H+ VTWLA W+DS+ G KYV L+ S+ KG SD KFE Sbjct: 215 TAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFE 271 [110][TOP] >UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani RepID=Q9NJG8_LEIDO Length = 949 Score = 144 bits (363), Expect = 4e-33 Identities = 85/178 (47%), Positives = 106/178 (59%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---EDEKAKKKAEKKAQTTAERKEAR 169 FF +R +L K I LE CDF I + HL E + ++ K EKKA KE + Sbjct: 420 FFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAI-----KEKQ 472 Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 +AEAE R + DGR E V NFRVEP LF GRG HPL GK+K R+QPED+T+N+G Sbjct: 473 DAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGE 529 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A +P P GH W + H+ VTWLA W+DS+ G KYV L+ S+ KG SD KFE Sbjct: 530 TAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFE 586 [111][TOP] >UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN Length = 635 Score = 144 bits (363), Expect = 4e-33 Identities = 85/178 (47%), Positives = 106/178 (59%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---EDEKAKKKAEKKAQTTAERKEAR 169 FF +R +L K I LE CDF I + HL E + ++ K EKKA KE + Sbjct: 105 FFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAI-----KEKQ 157 Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 +AEAE R + DGR E V NFRVEP LF GRG HPL GK+K R+QPED+T+N+G Sbjct: 158 DAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGE 214 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A +P P GH W + H+ VTWLA W+DS+ G KYV L+ S+ KG SD KFE Sbjct: 215 TAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFE 271 [112][TOP] >UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA Length = 785 Score = 144 bits (363), Expect = 4e-33 Identities = 77/177 (43%), Positives = 106/177 (59%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 F DF +L + A+ I K DF++I + + +K +KK + E+K+ R Sbjct: 222 FLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQVQKE----QKKQLSPQEKKQLRL 277 Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 + E + + +DGR E VGNFR+EP LF GRG HP GK+KRR+ PEDV LNL Sbjct: 278 EKEELEKPYKFCEIDGRVEQVGNFRIEPPGLFRGRGAHPKNGKLKRRVYPEDVVLNLDKE 337 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 APIPE P GH WG+I H++ V WL+ W+++I+ +KYV +A S KGMSD KFE Sbjct: 338 APIPE-PPKGHKWGEIRHDNTVQWLSMWRENISNSFKYVRFAANSTLKGMSDFKKFE 393 [113][TOP] >UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO Length = 1043 Score = 144 bits (362), Expect = 5e-33 Identities = 69/175 (39%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + K ++I KC+F + + + E K+KA T E K A++ E+ Sbjct: 558 FFKDFRKTMTP-KEKEIIKDFRKCNFQEMFEYFQAESEKRKA-----ATKEEKLAKKVES 611 Query: 182 ER-VRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E ++++ ++DG +E +GNFR+EP LF GRG+HP G +KRRI DV++N G N+ Sbjct: 612 EALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAARDVSINCGKNSK 671 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +P+ P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 672 VPQ-PPPGERWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYE 725 [114][TOP] >UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia vitripennis RepID=UPI00015B4D8F Length = 1019 Score = 143 bits (361), Expect = 6e-33 Identities = 70/174 (40%), Positives = 108/174 (62%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R ++ +++ AK IT L+KC+F+ + + K E+KA + E+K +E Sbjct: 534 FFHDWREVMTESERAK-ITDLKKCNFTEMHKYF----IMKSEERKAMSKEEKKAIKEKND 588 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E +++ + +DG +E +GNF++EP LF GRG+HP GK+K+R+ PEDV +N ++ Sbjct: 589 EIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRLVPEDVLINCSKDSVH 648 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PGH W +I H+ VTWLA W ++I G KYV L+ S KG D K+E Sbjct: 649 PK-PPPGHKWKEIRHDPTVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYE 701 [115][TOP] >UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis RepID=A4HB62_LEIBR Length = 637 Score = 143 bits (360), Expect = 8e-33 Identities = 78/174 (44%), Positives = 99/174 (56%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +R +L K I LE CDF I E+ KK +T E+K +E + Sbjct: 105 FFESWREIL--DKRQHPIRRLELCDFEPIYQWYLAEREKKLN----RTKEEKKSIKEKQD 158 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + + DGR E V NFRVEP LF GRG HPL GK+K R+QPE +T+N+G A + Sbjct: 159 MDAEPYRYCMWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKARVQPEGITINIGETAEV 218 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH WG + H+ VTWLA W+DS+ G KYV L+A S+ KG SD KFE Sbjct: 219 P-VPPAGHKWGAVQHDHTVTWLAMWRDSVVGNAKYVMLAASSSVKGQSDMMKFE 271 [116][TOP] >UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio RepID=Q6T721_DANRE Length = 600 Score = 142 bits (359), Expect = 1e-32 Identities = 74/175 (42%), Positives = 107/175 (61%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + K+IT+L KCDF+ I + + KAE+K T E K+ + EA Sbjct: 114 FFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE-----KAEEKKNMTKEEKQVLKDEA 167 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 R+ +F L+DG E +GNF++EP LF GRG+HP G++K+RIQPEDV +N ++ Sbjct: 168 ARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCSKDSK 227 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ H++ VTWLA W ++I KY+ L+ S KG D K+E Sbjct: 228 IPE-PPAGHKWKRVQHDNTVTWLASWLENIPKRPKYIMLNPSSKLKGEKDWQKYE 281 [117][TOP] >UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major RepID=Q4Q2K0_LEIMA Length = 634 Score = 142 bits (359), Expect = 1e-32 Identities = 80/174 (45%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +R +L K I LE CDF I ++ KK + K + A KE ++AEA Sbjct: 105 FFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQREKKLSRTKEEKKAI-KEKQDAEA 161 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E R + DGR E V NFRVEP LF GRG HPL GK+K R+QPED+T+N+G A + Sbjct: 162 EPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEV 218 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W + H+ VTWLA W+D++ G KYV L+ S+ KG SD KFE Sbjct: 219 P-VPPAGHKWAAVQHDHTVTWLAMWRDNVAGNMKYVMLAPSSSVKGQSDMVKFE 271 [118][TOP] >UniRef100_A7SLG4 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SLG4_NEMVE Length = 502 Score = 142 bits (359), Expect = 1e-32 Identities = 70/174 (40%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R + + + K I L+ CDF + + E K E+K T E+ E ++ Sbjct: 16 FFSDWRKEMTEEE-RKHIKDLKNCDFKEMHKYFE----MKNEERKNMTKEEKLEIKKKNE 70 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 E + ++ ++D ++ VGNF++EP LF GRGDHP GK+K+R+ PE+VT+N+G +A + Sbjct: 71 EILNEYGFCMMDHHKQRVGNFKIEPPGLFRGRGDHPKQGKLKKRVMPEEVTINIGKDAKV 130 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W K+I + VTWLA W ++I G YKYV L+ S KG D K+E Sbjct: 131 PD-PPAGHKWKKVICDDTVTWLACWIENIQGSYKYVMLNPTSRLKGEKDWRKYE 183 [119][TOP] >UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16 RepID=A8XXL4_CAEBR Length = 840 Score = 142 bits (358), Expect = 1e-32 Identities = 68/174 (39%), Positives = 110/174 (63%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R L+ + K IT L KCDF+ H+ + + +++ +KA T E+ + +E +A Sbjct: 339 FMKDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNEQREIRKAMTKEEKAKIKEEKA 393 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + V + +A++DG +E + NFR+EP +F GRG HP G +K+RI PEDV +N G ++ I Sbjct: 394 QEVVDYGIAIIDGHKEKIANFRIEPPGVFRGRGGHPKMGFIKKRIVPEDVIVNCGKDSVI 453 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P+ GH W ++ H++ V+WL W +S+ G KY+ L+A S KG D+ K+E Sbjct: 454 PKPPL-GHKWKEVRHDNTVSWLCSWTESVLGQNKYIMLNASSKIKGSKDYEKYE 506 [120][TOP] >UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E5D8 Length = 961 Score = 142 bits (357), Expect = 2e-32 Identities = 69/174 (39%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R ++ D K KVIT L KC+F + + ++ K E+KA + E+K ++ Sbjct: 482 FFNDWRKVMTD-KERKVITDLSKCNFKPMALYFQE----KSEERKAMSKEEKKVIKDQND 536 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++ +DG +E +GNFR+EP LF GRG+HP G +K+R+ PEDV +N ++ I Sbjct: 537 AIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMLKKRVLPEDVIINCSKDSKI 596 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W K+ H+ VTWLA W +++ G KYV L+ S KG D K+E Sbjct: 597 PK-PPDGHKWKKVQHDPSVTWLASWTENVQGNVKYVMLNPSSKLKGEKDMVKYE 649 [121][TOP] >UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN Length = 990 Score = 141 bits (356), Expect = 2e-32 Identities = 67/174 (38%), Positives = 103/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + +K ++I KC+F + + + E K+KA K + A++ E Sbjct: 519 FFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEKRKAATKEEKLAKKNENEAL-- 575 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V+++ ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G + + Sbjct: 576 --VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESHV 633 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 634 PS-PPPGQRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 686 [122][TOP] >UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732 RepID=C5DTC9_ZYGRC Length = 843 Score = 141 bits (355), Expect = 3e-32 Identities = 77/178 (43%), Positives = 108/178 (60%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172 FF DF +L + TK I S +KCDF+++ E +K ++K Q + + K+ Sbjct: 280 FFNDFIEVLNENGGTKNGINIESFDKCDFTKMFEFFEMQKEQRK-----QLSPQEKKQLR 334 Query: 173 AEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 E E+ + F +DGR+E VGNF++EP LF GRG HP TGK+KRR+ PEDV LNL Sbjct: 335 MEREKFEEPFKYCELDGRKEQVGNFKIEPPGLFRGRGAHPKTGKLKRRVYPEDVVLNLDK 394 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +A IP P G WG+I H++ V WLA W+++I+ +KYV +A S+ G SD KFE Sbjct: 395 DATIPPLP-EGQKWGEIRHDNTVQWLAMWRENISNSFKYVRFAANSSLNGQSDFKKFE 451 [123][TOP] >UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7Q9Y0_IXOSC Length = 499 Score = 140 bits (353), Expect = 5e-32 Identities = 68/175 (38%), Positives = 109/175 (62%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + K A++IT L KC+F I+ + K+K+E++ + E K+A +A+ Sbjct: 292 FFKDWRKTMTP-KEAELITDLSKCNFKEIDVYY-----KQKSEERKAMSKEEKQAIKAQN 345 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E++ ++ ++DG + +GNF++EP LF GRG+HP G +KRR+ PEDV +N+G A Sbjct: 346 EKLLEEYGFCIIDGHRQKIGNFKIEPPGLFRGRGEHPKMGMLKRRVMPEDVIINIGKEAK 405 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P GH W ++ H++ V+WL+ W ++I G KY+ L+ S KG D K+E Sbjct: 406 IPP-PPEGHRWKEVRHDNTVSWLSSWTENILGQTKYIMLNPSSKLKGEKDMQKYE 459 [124][TOP] >UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG Length = 622 Score = 140 bits (352), Expect = 7e-32 Identities = 73/178 (41%), Positives = 103/178 (57%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKKKAEKKAQTTAERKEAR 169 FF D+R + D + +I L+KCDF I +A +E K K EK RK + Sbjct: 104 FFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVEARKNMSKEEKLVCNIQFRKVLK 162 Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 EA + + ++ L+D E +GNF++EP LF GRG+HP GK+K+RIQPEDV +N Sbjct: 163 EANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGKLKKRIQPEDVIINCSK 222 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 + IP P GH W ++ H++ VTWLA W ++I G KY+ L+A S KG D K+E Sbjct: 223 ESRIP-VPPAGHRWKEVRHDNTVTWLASWTENIQGSIKYIMLNANSKLKGEKDWEKYE 279 [125][TOP] >UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR Length = 874 Score = 139 bits (351), Expect = 9e-32 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160 FF DF+ +L T AK I EK DFS++ A+ + + K A A+ AE+ Sbjct: 302 FFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWAYKDAQTKAKNARSSAEKKAEKA 361 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E + +A + DGR+E VGN RVE LF GRGDHP TG +K+R+ PE +T+N Sbjct: 362 ERDKRDAP----YLYCKWDGRKEKVGNPRVEIPGLFRGRGDHPKTGCIKKRVLPEQITIN 417 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 +G A +PE P GH W + H++ TWLA W+++I G YKYV L+A S KG +D KF Sbjct: 418 IGKEAKVPE-PPAGHKWKAVQHDNKATWLAMWQENINGHYKYVMLAANSTVKGKADFKKF 476 Query: 521 E 523 E Sbjct: 477 E 477 [126][TOP] >UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=B5DMS2_DROPS Length = 1054 Score = 139 bits (350), Expect = 1e-31 Identities = 68/175 (38%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + +K ++I KC+F + + + E +EK+ Q T E K A++ E Sbjct: 569 FFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNEN 622 Query: 182 ER-VRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E ++++ ++DG +E +GNFR+EP LF GRG+HP G +KRRI DV++N G + Sbjct: 623 EALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASDVSINCGKESK 682 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 683 VPP-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 736 [127][TOP] >UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE Length = 1042 Score = 139 bits (350), Expect = 1e-31 Identities = 68/175 (38%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + +K ++I KC+F + + + E +EK+ Q T E K A++ E Sbjct: 557 FFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNEN 610 Query: 182 ER-VRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E ++++ ++DG +E +GNFR+EP LF GRG+HP G +KRRI DV++N G + Sbjct: 611 EALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASDVSINCGKESK 670 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 671 VPP-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 724 [128][TOP] >UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I, mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B7ZAR5_HUMAN Length = 503 Score = 139 bits (350), Expect = 1e-31 Identities = 73/175 (41%), Positives = 108/175 (61%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R +A + +VI SL+KCDF+ I + D+ A +K + E K+ + EA Sbjct: 16 FFSDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 69 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG +E +GNF++EP LF GRGDHP G +KRRI PEDV +N ++ Sbjct: 70 EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 129 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W +S+ KY+ L+ S KG + KFE Sbjct: 130 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 183 [129][TOP] >UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes RepID=TOP1M_PANTR Length = 601 Score = 139 bits (349), Expect = 2e-31 Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R +A + +VI SL+KCDF+ I + D+ A +K + E K+ + EA Sbjct: 114 FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 167 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E++ R+F ++DG +E +GNF++EP LF GRGDHP G +KRRI PEDV +N ++ Sbjct: 168 EKLQREFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRIMPEDVVINCSRDSK 227 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W +S+ KY+ L+ S KG + KFE Sbjct: 228 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 281 [130][TOP] >UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=UPI0001760D92 Length = 748 Score = 138 bits (348), Expect = 2e-31 Identities = 70/175 (40%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L+KCDF+++ + K ++E + Q + E K+ + E Sbjct: 261 FFKDWRKEMTSEEKSK-ITELKKCDFTQMHEYF-----KAQSEARKQMSKEEKQKNKEEN 314 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + L+D E +GNFR+EP LF GRGDHP GK+KRRI+PED+ +N ++ Sbjct: 315 ERILQEYGFCLMDNHRERIGNFRIEPPGLFRGRGDHPKMGKLKRRIRPEDIIINCSKDSV 374 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 375 QPKAP-PGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 428 [131][TOP] >UniRef100_B4DYD2 cDNA FLJ50294, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4DYD2_HUMAN Length = 503 Score = 138 bits (348), Expect = 2e-31 Identities = 74/175 (42%), Positives = 107/175 (61%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R +A + +VI SL+KCDF+ I + D+ A +K + E K+ + EA Sbjct: 16 FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 69 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG +E +GNF++EP LF GRGDHP G +KRRI PEDV +N ++ Sbjct: 70 EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 129 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W +SI KY+ L+ S KG + KFE Sbjct: 130 IPE-PPAGHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFE 183 [132][TOP] >UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra magnipapillata RepID=UPI000192545C Length = 726 Score = 138 bits (347), Expect = 3e-31 Identities = 71/175 (40%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAE 178 FF D+R + + +I SL+KCDF + A+ K AE+K T E K+A +EA Sbjct: 227 FFEDWRKEMTAEE-RNIIKSLDKCDFKEMHAYF-----MKCAEEKRNMTKEEKQAIKEAN 280 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + ++ +DG ++ VGNFR+EP LF GRGDHP GK+K+R+ ++V +N+G A Sbjct: 281 LKIAEKYGFCEMDGHKQKVGNFRIEPPGLFRGRGDHPKQGKLKKRVSAKEVIINIGKEAK 340 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +P+ P G W + H++ V+WLA W ++I GGYKYV L+A + KG D K+E Sbjct: 341 VPQ-PPEGQKWKAVQHDNTVSWLACWVENIAGGYKYVMLNAATRLKGEKDWQKYE 394 [133][TOP] >UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus RepID=UPI00017968A4 Length = 655 Score = 138 bits (347), Expect = 3e-31 Identities = 73/175 (41%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R + + K+I L+KCDF+ I + D+ A +KA + E K+ + EA Sbjct: 168 FFSDWRKEMTAEE-RKIIKHLDKCDFTEIHRYFVDKTAARKALSR-----EEKQKLKEEA 221 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F +DG E +GNF+ EP LF GRGDHP G +KRRI PEDVT+N ++ Sbjct: 222 EKLQQEFGYCTLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRILPEDVTINCSRDSK 281 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP+ P GH W ++ ++ VTWLA W ++I KYV L+ S KG D K+E Sbjct: 282 IPK-PPAGHQWKEVRSDNTVTWLASWTENIQNSIKYVMLNPSSKLKGEKDWQKYE 335 [134][TOP] >UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A48 Length = 632 Score = 138 bits (347), Expect = 3e-31 Identities = 73/174 (41%), Positives = 101/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + D + +I L KCDF I A KAK +A K T E++ +EA Sbjct: 144 FFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKAKVEARKN-MTKEEKQALKEANQ 198 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + V +F L+D E +GNF++EP LF GRG+HP G +K+RIQPED+ +N A I Sbjct: 199 KIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGMLKKRIQPEDIIINCSKEACI 258 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W ++ H++ VTWL W ++I G KY+ L+A S KG D K+E Sbjct: 259 P-VPPAGHRWKEVRHDNTVTWLVSWTENIQGSIKYIMLNANSKLKGEKDWEKYE 311 [135][TOP] >UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI Length = 997 Score = 138 bits (347), Expect = 3e-31 Identities = 65/174 (37%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + D + ++I KC+F + + E ++KA K + A++ E Sbjct: 512 FFKDFRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAESERRKAATKDEKLAKKNENEAL-- 568 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V+++ ++DG +E +GNFR+EP LF GRG+HP G +KRRI +V++N G N+ + Sbjct: 569 --VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASEVSINCGKNSKV 626 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 627 P-TPPPGQRWKEVRHDNTVTWLASWVENVQGQVKYIMLNPSSKLKGEKDHIKYE 679 [136][TOP] >UniRef100_B7Z9E8 cDNA, FLJ78812, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B7Z9E8_HUMAN Length = 503 Score = 138 bits (347), Expect = 3e-31 Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R +A + +VI SL+KCDF+ I + D+ A +K + E K+ + EA Sbjct: 16 FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 69 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG +E +GNF++EP LF GRGDHP G +KRRI PEDV +N ++ Sbjct: 70 EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 129 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W +S+ KY+ L+ S KG + KFE Sbjct: 130 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 183 [137][TOP] >UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens RepID=TOP1M_HUMAN Length = 601 Score = 138 bits (347), Expect = 3e-31 Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R +A + +VI SL+KCDF+ I + D+ A +K + E K+ + EA Sbjct: 114 FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 167 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG +E +GNF++EP LF GRGDHP G +KRRI PEDV +N ++ Sbjct: 168 EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 227 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W +S+ KY+ L+ S KG + KFE Sbjct: 228 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 281 [138][TOP] >UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B1 Length = 751 Score = 137 bits (346), Expect = 3e-31 Identities = 71/174 (40%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + AK IT L+KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 264 FFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-RKAMTKEEKLKIKEENE 318 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++QF ++D +E + NFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 319 RILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKY 378 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 379 PE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 431 [139][TOP] >UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B0 Length = 751 Score = 137 bits (346), Expect = 3e-31 Identities = 71/174 (40%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + AK IT L+KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 264 FFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-RKAMTKEEKLKIKEENE 318 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++QF ++D +E + NFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 319 RILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKY 378 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 379 PE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 431 [140][TOP] >UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster RepID=Q8IR39_DROME Length = 581 Score = 137 bits (346), Expect = 3e-31 Identities = 65/174 (37%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + + ++I KC+F + + + E K+KA K + ++ E Sbjct: 110 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 166 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G ++ + Sbjct: 167 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 224 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 225 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 277 [141][TOP] >UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster RepID=Q494M1_DROME Length = 974 Score = 137 bits (346), Expect = 3e-31 Identities = 65/174 (37%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + + ++I KC+F + + + E K+KA K + ++ E Sbjct: 503 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 559 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G ++ + Sbjct: 560 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 617 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 618 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 670 [142][TOP] >UniRef100_Q1WWG8 IP16129p (Fragment) n=1 Tax=Drosophila melanogaster RepID=Q1WWG8_DROME Length = 382 Score = 137 bits (346), Expect = 3e-31 Identities = 65/174 (37%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + + ++I KC+F + + + E K+KA K + ++ E Sbjct: 16 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 72 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G ++ + Sbjct: 73 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 130 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 131 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 183 [143][TOP] >UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME Length = 581 Score = 137 bits (346), Expect = 3e-31 Identities = 65/174 (37%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + + ++I KC+F + + + E K+KA K + ++ E Sbjct: 110 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 166 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G ++ + Sbjct: 167 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 224 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 225 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 277 [144][TOP] >UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster RepID=TOP1_DROME Length = 972 Score = 137 bits (346), Expect = 3e-31 Identities = 65/174 (37%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + + ++I KC+F + + + E K+KA K + ++ E Sbjct: 501 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 557 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G ++ + Sbjct: 558 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 615 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 616 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 668 [145][TOP] >UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1 Tax=Tribolium castaneum RepID=UPI00017582B6 Length = 936 Score = 137 bits (345), Expect = 4e-31 Identities = 67/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAE 178 FF D+R ++++++ KVI L+KC+F + A+ D AEK T E K+A +E Sbjct: 451 FFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMD-----LAEKNRNRTKEEKQALKEKN 504 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ++++ +DG +E +GNF++EP LF GRG+HP G +KRR++ ED+ +N ++ Sbjct: 505 EALIKEYGFCNIDGHKEKIGNFKIEPPGLFRGRGEHPKMGMLKRRVEAEDIIINCSQDSK 564 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P PGH W ++ H+ VTWLA W +++ KY+ L+ S KG D K+E Sbjct: 565 IPE-PPPGHKWKEVRHDDNVTWLASWTENVQNQVKYIMLNPSSKLKGEKDWQKYE 618 [146][TOP] >UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI Length = 1045 Score = 137 bits (344), Expect = 6e-31 Identities = 65/174 (37%), Positives = 100/174 (57%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + K ++I KC+F + E K+KA K + A++ E Sbjct: 560 FFKDFRKSMTP-KEKEIIKDFRKCNFQEMHQFFLAESEKRKAATKEEKLAKKNENEAL-- 616 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++++ ++DG +E +GNFR+EP LF GRG+HP G +KRRI DV++N G + + Sbjct: 617 --IKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAAADVSINCGKQSKV 674 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 675 PQ-PPPGERWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYE 727 [147][TOP] >UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER Length = 969 Score = 137 bits (344), Expect = 6e-31 Identities = 66/174 (37%), Positives = 101/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + +K ++I KC F+ + + E K+KA K + ++ E Sbjct: 498 FFKDFRKSMT-SKEREIIKDFRKCGFNEMFNFFQAESEKRKAATKEEKLIKKNENEAL-- 554 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G + + Sbjct: 555 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESKV 612 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 613 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 665 [148][TOP] >UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=O17966-2 Length = 734 Score = 137 bits (344), Expect = 6e-31 Identities = 69/174 (39%), Positives = 107/174 (61%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R ++ + + I L+KCDF I+A+ ++++ +KA K + + KE +EAE Sbjct: 248 FMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQREIRKAMTKEEKL-KIKEEKEAE- 304 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V+ + +A++DG + V NFR+EP +F GRG HP G +K+RI PEDV +N G + I Sbjct: 305 --VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEI 362 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PGH W ++ H++ VTWL W +S+ G KY+ L+ S KG D K+E Sbjct: 363 PK-PPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYE 415 [149][TOP] >UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL Length = 806 Score = 137 bits (344), Expect = 6e-31 Identities = 69/174 (39%), Positives = 107/174 (61%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R ++ + + I L+KCDF I+A+ ++++ +KA K + + KE +EAE Sbjct: 320 FMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQREIRKAMTKEEKL-KIKEEKEAE- 376 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V+ + +A++DG + V NFR+EP +F GRG HP G +K+RI PEDV +N G + I Sbjct: 377 --VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEI 434 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PGH W ++ H++ VTWL W +S+ G KY+ L+ S KG D K+E Sbjct: 435 PK-PPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYE 487 [150][TOP] >UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5C65 Length = 755 Score = 136 bits (343), Expect = 8e-31 Identities = 69/174 (39%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + AK IT L+KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 268 FFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEENE 322 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++Q+ ++D +E + NFR+EP LF GRGDHP G +KRRI+P+D+ +N ++ Sbjct: 323 RLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPQDIIINCSKDSKY 382 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 383 PE-PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 435 [151][TOP] >UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU Length = 753 Score = 136 bits (343), Expect = 8e-31 Identities = 69/174 (39%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + AK IT L+KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 266 FFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEENE 320 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++Q+ ++D +E + NFR+EP LF GRGDHP G +KRRI+P+D+ +N ++ Sbjct: 321 RLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPQDIIINCSKDSKY 380 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 381 PE-PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 433 [152][TOP] >UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA Length = 580 Score = 136 bits (343), Expect = 8e-31 Identities = 66/174 (37%), Positives = 100/174 (57%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + +K ++I KC F + + E K+KA K + ++ E Sbjct: 109 FFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEKRKAATKEEKLIKKNENEAL-- 165 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRIQ DV++N G + + Sbjct: 166 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESKV 223 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 224 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 276 [153][TOP] >UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JVY3_SCHJY Length = 654 Score = 136 bits (343), Expect = 8e-31 Identities = 68/157 (43%), Positives = 94/157 (59%), Gaps = 2/157 (1%) Frame = +2 Query: 2 FFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF DF+A+ A K A + CDF + + E K KK K E+KE ++ Sbjct: 301 FFRDFQAVCKEAGMKSADIPKEFNSCDFRPMFEYFESLKEAKKNMSKE----EKKELKKK 356 Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 + E +F L+DGR+E VGNFR+EP LF GRG HP TG +KRR+ PE +T+N+G A Sbjct: 357 KEEEEEKFKWCLLDGRKEKVGNFRIEPPGLFRGRGSHPKTGTLKRRVYPEQITINIGKGA 416 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKY 466 +PE P+PGH W ++ H+ VTWLA W +++ G KY Sbjct: 417 KVPE-PLPGHKWAEVRHDDQVTWLAMWHENVNGNVKY 452 [154][TOP] >UniRef100_Q4V7M4 MGC115546 protein n=1 Tax=Xenopus laevis RepID=Q4V7M4_XENLA Length = 503 Score = 135 bits (341), Expect = 1e-30 Identities = 66/174 (37%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + VIT L+KCDF+ + + + K EKK ++ ++ + +E Sbjct: 16 FFVDWRKEMT-LEEKMVITDLDKCDFTEMFTYYKG----KMEEKKNKSKEDKLKIKEENE 70 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + + ++ +D E +GNF++EP LF GRGDHP G +K+RI PED+ +N ++ I Sbjct: 71 KLLEEYGYCAMDHHREKIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKI 130 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PGH W ++ H++ VTWLA W +++ G KY+ L+A S KG D K+E Sbjct: 131 PE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYE 183 [155][TOP] >UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PY85_MALGO Length = 877 Score = 135 bits (341), Expect = 1e-30 Identities = 74/176 (42%), Positives = 97/176 (55%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF DF L K I EK DF + + K + KK+ + RK A Sbjct: 183 FFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSMRKAELAA 242 Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 ++ + LVDG E+ GN VEP LFLGRG HP G+VK RIQPE +T+N + Sbjct: 243 RRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGAHPKAGRVKTRIQPEQITINHSADH 302 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P+ P GH+WG+++ VTWLA W+++I GG+KYV+L A S FK SD KFE Sbjct: 303 PPPK-PPKGHSWGEVVERKDVTWLALWRENINGGFKYVFLDASSTFKTESDREKFE 357 [156][TOP] >UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus RepID=UPI0000ECD01B Length = 593 Score = 135 bits (339), Expect = 2e-30 Identities = 69/175 (39%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + ++I L+KCDF I + D+ +KA K E K+ + EA Sbjct: 106 FFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEARKALSK-----EEKQKLKEEA 159 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 +++++ + ++DG E +GNF+ EP LF GRGDHP G +K+RI PEDV +N ++ Sbjct: 160 DKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKKRIMPEDVIINCSKDSK 219 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE PV GH W ++ ++ VTWLA W ++I KY+ L+ S KG D KFE Sbjct: 220 IPEPPV-GHKWKEVRFDNTVTWLASWTENIQNSLKYIMLNPSSKLKGEKDWQKFE 273 [157][TOP] >UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus RepID=Q6T722_CHICK Length = 593 Score = 135 bits (339), Expect = 2e-30 Identities = 69/175 (39%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + ++I L+KCDF I + D+ +KA K E K+ + EA Sbjct: 106 FFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEARKALSK-----EEKQKLKEEA 159 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 +++++ + ++DG E +GNF+ EP LF GRGDHP G +K+RI PEDV +N ++ Sbjct: 160 DKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKKRIMPEDVIINCSKDSK 219 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE PV GH W ++ ++ VTWLA W ++I KY+ L+ S KG D KFE Sbjct: 220 IPEPPV-GHKWKEVRFDNTVTWLASWTENIQNSLKYIMLNPSSKLKGEKDWQKFE 273 [158][TOP] >UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE Length = 970 Score = 135 bits (339), Expect = 2e-30 Identities = 64/174 (36%), Positives = 100/174 (57%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + + ++I KC F + + + E K+KA K + ++ E Sbjct: 499 FFKDFRKSMTPRE-REIIKDFRKCGFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 555 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++F ++DG +E +GNFR+EP LF GRG+HP G +KRRI DV++N G ++ + Sbjct: 556 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIHASDVSINCGKDSKV 613 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 614 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 666 [159][TOP] >UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR Length = 767 Score = 135 bits (339), Expect = 2e-30 Identities = 63/174 (36%), Positives = 103/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + VIT+L KCDF+++ + +D+ +K K E+ + +E Sbjct: 280 FFKDWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSEARKQMSKE----EKLKIKEENE 334 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 335 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [160][TOP] >UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus RepID=TOP1M_RAT Length = 593 Score = 135 bits (339), Expect = 2e-30 Identities = 70/175 (40%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D++ + + K+IT L+KCDFS I H + +AE + E+K+ + EA Sbjct: 107 FFSDWQKEMTAEE-RKLITHLDKCDFSEIHRHFME-----RAEARRTLPREQKQKLKEEA 160 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG E +GNF+ EP LF GRGDHP G +KRR+ PEDV +N ++ Sbjct: 161 EKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSK 220 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ V WLA W ++I +KY+ L+ S KG D K+E Sbjct: 221 IPE-PPAGHQWKEVRSDNTVMWLAAWVENIQNSFKYIILNPSSKPKGEMDWQKYE 274 [161][TOP] >UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio RepID=UPI000176075D Length = 531 Score = 134 bits (338), Expect = 3e-30 Identities = 70/175 (40%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R + + ++I L+KCDF + A H E +A+K K+ E+ +EA Sbjct: 44 FFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKE-----EKLVNKEAN 97 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + V ++ ++D E +GNF++EP LF GRGDHP G +K+RI+PEDV +N + Sbjct: 98 QKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPKQGMLKKRIRPEDVIINCSKESR 157 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ H+ VTWLA W +++ G KYV L+A S KG D K+E Sbjct: 158 IPEAPA-GHKWKEVRHDKTVTWLASWTENVQGSCKYVMLNANSKLKGEKDWEKYE 211 [162][TOP] >UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI0001555600 Length = 689 Score = 134 bits (338), Expect = 3e-30 Identities = 70/175 (40%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R + + K I LE+CDF+ I + D+ +KA K E K+ + EA Sbjct: 202 FFSDWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNEARKALPK-----EEKQKLKEEA 255 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E++++ F ++DG E +GNF+ EP LF GRGDHP G +K+RI PEDV +N ++ Sbjct: 256 EKLQEEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGLLKKRIMPEDVIINCSKDSK 315 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W ++I KY+ L+ S KG D K+E Sbjct: 316 IPE-PPSGHKWKEVRFDNTVTWLASWTENIQNSIKYIMLNPSSKLKGEKDWQKYE 369 [163][TOP] >UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio RepID=UPI0001A2C88D Length = 609 Score = 134 bits (338), Expect = 3e-30 Identities = 70/175 (40%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D+R + + ++I L+KCDF + A H E +A+K K+ E+ +EA Sbjct: 122 FFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKE-----EKLVNKEAN 175 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 + V ++ ++D E +GNF++EP LF GRGDHP G +K+RI+PEDV +N + Sbjct: 176 QKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPKQGMLKKRIRPEDVIINCSKESR 235 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ H+ VTWLA W +++ G KYV L+A S KG D K+E Sbjct: 236 IPEAPA-GHKWKEVRHDKTVTWLASWTENVQGSCKYVMLNANSKLKGEKDWEKYE 289 [164][TOP] >UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA Length = 1019 Score = 134 bits (336), Expect = 5e-30 Identities = 74/176 (42%), Positives = 96/176 (54%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF DF+ L + I S +K DF + + K + KKA + RK E Sbjct: 224 FFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEE 283 Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 ++ + LVDG E+ VGN VEP LFLGRG HP GKVKRRI P D+T+N + Sbjct: 284 RKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADH 343 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P+ P +W +++ VTWLA WK++I G YKYV+L A S FK SD KFE Sbjct: 344 PAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFE 399 [165][TOP] >UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155C8C4 Length = 781 Score = 133 bits (335), Expect = 6e-30 Identities = 64/174 (36%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + + IT+L KCDF+ + + KA+ +A K+ + E+++ +E Sbjct: 294 FFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF---KAQSEARKQ-MSKEEKQKIKEENE 348 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NFR+EP LF GRG+HP G +KRRIQPED+ +N ++ + Sbjct: 349 QLLKEYGFCVMDNHRERIANFRIEPPGLFRGRGNHPKMGMLKRRIQPEDIIINCSKDSKV 408 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 409 PP-PPPGHRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 461 [166][TOP] >UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B1DB6 Length = 770 Score = 133 bits (335), Expect = 6e-30 Identities = 69/175 (39%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ + E Sbjct: 283 FFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEEN 336 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E +GNFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 337 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 396 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S KG D K+E Sbjct: 397 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 450 [167][TOP] >UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG Length = 783 Score = 133 bits (335), Expect = 6e-30 Identities = 69/175 (39%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ + E Sbjct: 264 FFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEEN 317 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E +GNFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 318 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 377 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S KG D K+E Sbjct: 378 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 431 [168][TOP] >UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG RepID=B9Q6S5_TOXGO Length = 953 Score = 133 bits (335), Expect = 6e-30 Identities = 69/167 (41%), Positives = 99/167 (59%) Frame = +2 Query: 23 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 202 L + K + + CDFS I+ +L+ K+K KK + E++ ++ + + + Sbjct: 392 LATEYKEGERMVGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYA 447 Query: 203 VALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382 ALVD E VGN RVEP LF GRG+HP G +KRRI DV LNL +AP+P +PG Sbjct: 448 YALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPG 507 Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 H W + H++ VTWLA ++DSI KY++L+A+S FKG D K+E Sbjct: 508 HAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYE 554 [169][TOP] >UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1 RepID=B9PWF4_TOXGO Length = 953 Score = 133 bits (335), Expect = 6e-30 Identities = 69/167 (41%), Positives = 99/167 (59%) Frame = +2 Query: 23 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 202 L + K + + CDFS I+ +L+ K+K KK + E++ ++ + + + Sbjct: 392 LATEYKEGERMVGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYA 447 Query: 203 VALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382 ALVD E VGN RVEP LF GRG+HP G +KRRI DV LNL +AP+P +PG Sbjct: 448 YALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPG 507 Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 H W + H++ VTWLA ++DSI KY++L+A+S FKG D K+E Sbjct: 508 HAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYE 554 [170][TOP] >UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49 RepID=B6KM03_TOXGO Length = 953 Score = 133 bits (335), Expect = 6e-30 Identities = 69/167 (41%), Positives = 99/167 (59%) Frame = +2 Query: 23 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 202 L + K + + CDFS I+ +L+ K+K KK + E++ ++ + + + Sbjct: 392 LATEYKEGERMVGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYA 447 Query: 203 VALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382 ALVD E VGN RVEP LF GRG+HP G +KRRI DV LNL +AP+P +PG Sbjct: 448 YALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPG 507 Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 H W + H++ VTWLA ++DSI KY++L+A+S FKG D K+E Sbjct: 508 HAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYE 554 [171][TOP] >UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR Length = 1063 Score = 133 bits (335), Expect = 6e-30 Identities = 64/174 (36%), Positives = 100/174 (57%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR + K ++I KC+F + + E K+KA K + ++ E Sbjct: 578 FFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEKRKAATKEEKLLKKNENEAL-- 634 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V+++ ++DG +E +GNFR+EP LF GRG+HP G +KRRI DV++N G + + Sbjct: 635 --VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAAADVSINCGKQSKV 692 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P+ G W ++ H++ VTWLA W +++ G KY+ L+ S KG DH K+E Sbjct: 693 PQPPM-GGRWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYE 745 [172][TOP] >UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax adhaerens RepID=B3S6N7_TRIAD Length = 560 Score = 133 bits (335), Expect = 6e-30 Identities = 70/177 (39%), Positives = 105/177 (59%), Gaps = 3/177 (1%) Frame = +2 Query: 2 FFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 F+ DFR + A+ KV + KCDFS+I E K KAE++ + E K + Sbjct: 73 FWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EYYKMKAEERRNMSKEEKNKLKK 124 Query: 176 EAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352 E E + Q + ++DG + VGNF++EP LF GRGDHP GK+KRRI+ +D+ +N+G + Sbjct: 125 ENEELMQEYGFCIIDGHRQRVGNFKIEPPGLFRGRGDHPKQGKIKRRIEAKDIIINIGKD 184 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A +P P PG W ++ +++ VTWLA W ++I G KY+ L+ S K D+ K+E Sbjct: 185 AKLP-APPPGQKWKEVRYDNKVTWLASWTENINGSIKYIMLNPTSKIKAEKDYQKYE 240 [173][TOP] >UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus RepID=TOP1M_MOUSE Length = 593 Score = 133 bits (335), Expect = 6e-30 Identities = 70/175 (40%), Positives = 104/175 (59%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R + + ++IT L+KCDF+ I H + +AE + E+K+ + EA Sbjct: 107 FFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE-----RAEARRTLPREQKQKLKEEA 160 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG E +GNF+ EP LF GRGDHP G +KRR+ PEDV +N ++ Sbjct: 161 EKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSK 220 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ V WLA W + I +KYV L+ S KG D K+E Sbjct: 221 IPE-PPAGHQWKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYE 274 [174][TOP] >UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata RepID=UPI000194D872 Length = 775 Score = 133 bits (334), Expect = 8e-30 Identities = 66/175 (37%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + ITSL KCDF+ + + K ++E + Q + E K+ + E Sbjct: 288 FFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQSEARKQMSKEEKQKIKEEN 341 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ +++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N ++ Sbjct: 342 ERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDSK 401 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 402 IP-APPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 455 [175][TOP] >UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus caballus RepID=UPI0001797824 Length = 765 Score = 133 bits (334), Expect = 8e-30 Identities = 64/174 (36%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +ITSL KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 278 FFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 332 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 333 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445 [176][TOP] >UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792028 Length = 1011 Score = 133 bits (334), Expect = 8e-30 Identities = 65/174 (37%), Positives = 101/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F D+R + K ++IT L C+F + + KK E+KA + E+K+ +E Sbjct: 262 FLKDWRKTMTP-KEKELITDLSLCNFKEMNVYF----TKKSEERKAMSKEEKKKIKEENE 316 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 +++ +DG +E +GNF++EP LF GRG+HP G +K+R+ PEDV +N ++ I Sbjct: 317 ALQKEYGFCTIDGHKEKIGNFKIEPPGLFRGRGEHPKMGMLKKRVVPEDVLINCSKDSNI 376 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PGH W ++ H+ VTWLA W +++ G KYV L+ S KG D K+E Sbjct: 377 PK-PPPGHKWKEVRHDFGVTWLASWIENVQGQVKYVMLNPSSKLKGEKDWQKYE 429 [177][TOP] >UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta RepID=UPI00006D45A8 Length = 767 Score = 133 bits (334), Expect = 8e-30 Identities = 63/174 (36%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 280 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 334 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 335 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [178][TOP] >UniRef100_UPI000069F011 UPI000069F011 related cluster n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069F011 Length = 503 Score = 133 bits (334), Expect = 8e-30 Identities = 65/174 (37%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 +F D+R + + VIT L KCDF+ + + + K EKK ++ ++ + +E Sbjct: 16 YFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKNKSKEDKLKIKEENE 70 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ +D E +GNF++EP LF GRGDHP G +K+RI PED+ +N ++ I Sbjct: 71 KLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKI 130 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PGH W ++ H++ VTWLA W +++ G KY+ L+A S KG D K+E Sbjct: 131 PE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYE 183 [179][TOP] >UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus (Silurana) tropicalis RepID=Q0V9D3_XENTR Length = 495 Score = 133 bits (334), Expect = 8e-30 Identities = 65/174 (37%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 +F D+R + + VIT L KCDF+ + + + K EKK ++ ++ + +E Sbjct: 194 YFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKNKSKEDKLKIKEENE 248 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ +D E +GNF++EP LF GRGDHP G +K+RI PED+ +N ++ I Sbjct: 249 KLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKI 308 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P PGH W ++ H++ VTWLA W +++ G KY+ L+A S KG D K+E Sbjct: 309 PE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYE 361 [180][TOP] >UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA Length = 560 Score = 133 bits (334), Expect = 8e-30 Identities = 63/174 (36%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 73 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 127 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 128 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 187 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 188 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 240 [181][TOP] >UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus RepID=B0WA62_CULQU Length = 962 Score = 133 bits (334), Expect = 8e-30 Identities = 68/174 (39%), Positives = 102/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + ++ K I L+KC+F + A+ D K + K + A KE EA Sbjct: 480 FFKDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSEKNRNRSKEEKLA-LKEQNEA-- 535 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V+++ + +DG +E +GNFR+EP LF GRG+HP G VKRR+ PEDV +N ++ Sbjct: 536 -LVKEYGICNIDGHKEKIGNFRIEPPGLFRGRGEHPKMGLVKRRVMPEDVIINCAKDSVY 594 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W ++ H++ V+WLA W +++ G KYV L+ S KG D K+E Sbjct: 595 PKAP-EGHRWKEVRHDNTVSWLASWTENVQGQVKYVMLNPSSKLKGEKDWQKYE 647 [182][TOP] >UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus scrofa RepID=UPI00017EFDA4 Length = 748 Score = 132 bits (333), Expect = 1e-29 Identities = 63/174 (36%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 262 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 316 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 317 KLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 376 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 377 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 429 [183][TOP] >UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B3173 Length = 622 Score = 132 bits (333), Expect = 1e-29 Identities = 71/178 (39%), Positives = 103/178 (57%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + D + +I L+KCDF I A KAK +A K + E+ +EA Sbjct: 128 FFQDWRKEMTDEE-RSLIQELDKCDFGEIHAM---HKAKVEARKN-MSKEEKLVLKEANQ 182 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + + ++ L+D E +GNF++EP LF GRG+HP GK+K+RIQPEDV +N + Sbjct: 183 KILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGKLKKRIQPEDVIINCSNSRVD 242 Query: 362 PECPVP----GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 E +P GH W ++ H++ VTWLA W ++I G KY+ L+A S KG D K+E Sbjct: 243 RESRIPVPPAGHRWKEVRHDNTVTWLASWTENIQGSIKYIMLNANSKLKGEKDWEKYE 300 [184][TOP] >UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN Length = 765 Score = 132 bits (333), Expect = 1e-29 Identities = 63/174 (36%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 278 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 332 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 333 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445 [185][TOP] >UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA Length = 829 Score = 132 bits (333), Expect = 1e-29 Identities = 68/175 (38%), Positives = 102/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D++ + T +IT+L KCDF+ + + K+++E + T E K +AE Sbjct: 334 FFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF-----KEQSEARKNMTKEEKLKIKAEN 387 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E + NFR+EP LF GRGDHP GK+K+RI PED+ +N ++ Sbjct: 388 ERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDSK 447 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P GH W ++ H+ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 448 IPVAPA-GHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 501 [186][TOP] >UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN Length = 765 Score = 132 bits (333), Expect = 1e-29 Identities = 63/174 (36%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 278 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 332 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 333 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445 [187][TOP] >UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE Length = 767 Score = 132 bits (333), Expect = 1e-29 Identities = 63/174 (36%), Positives = 106/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 280 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 334 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 335 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [188][TOP] >UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A49 Length = 692 Score = 132 bits (332), Expect = 1e-29 Identities = 70/181 (38%), Positives = 100/181 (55%), Gaps = 7/181 (3%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAE------RK 160 FF D+R + D + +I L KCDF I A H +A+K K+ + + Sbjct: 143 FFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAMHKAKVEARKNMTKEEKQVCNIHFIMLKN 201 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 +EA + V +F L+D E +GNF++EP LF GRG+HP G +K+RIQPED+ +N Sbjct: 202 ALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGMLKKRIQPEDIIIN 261 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 A IP P GH W ++ H++ VTWL W ++I G KY+ L+A S KG D K+ Sbjct: 262 CSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTENIQGSIKYIMLNANSKLKGEKDWEKY 320 Query: 521 E 523 E Sbjct: 321 E 321 [189][TOP] >UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE Length = 592 Score = 132 bits (332), Expect = 1e-29 Identities = 71/175 (40%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R + + ++IT L+KCDF+ I H + +AE + E+K+ +E EA Sbjct: 107 FFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE-----RAEARRTLPREQKQLKE-EA 159 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E+++Q F ++DG E +GNF+ EP LF GRGDHP G +KRR+ PEDV +N ++ Sbjct: 160 EKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSK 219 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ V WLA W + I +KYV L+ S KG D K+E Sbjct: 220 IPE-PPAGHQWKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYE 273 [190][TOP] >UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus RepID=UPI00006154BF Length = 769 Score = 132 bits (331), Expect = 2e-29 Identities = 63/174 (36%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 282 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 336 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 337 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 396 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 397 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 449 [191][TOP] >UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK Length = 766 Score = 132 bits (331), Expect = 2e-29 Identities = 65/175 (37%), Positives = 102/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + ITSL KCDF+ + + K + E + Q + E K+ + E Sbjct: 279 FFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQTEARKQMSKEEKQKIKEEN 332 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ +++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N ++ Sbjct: 333 ERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDSK 392 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 393 VPP-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 446 [192][TOP] >UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE Length = 725 Score = 132 bits (331), Expect = 2e-29 Identities = 74/171 (43%), Positives = 100/171 (58%), Gaps = 5/171 (2%) Frame = +2 Query: 26 LADTKFAKVITSLEKCDFSRIEAHLEDEKA---KKKAEKKAQTTAERKEAREAEAERVRQ 196 L TKF L+K DF++I HLE ++ K E+K Q ER + R Sbjct: 107 LMQTKFEGF--QLDKADFTKIREHLEQQRLLRLNKSDEQKKQEKLERDQ-------RELF 157 Query: 197 FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPV 376 + ALVDG E VGN+ +E LF GRG+HP G +K RI PE++T+NL AP+P+C + Sbjct: 158 YGYALVDGCLERVGNYTLEQPTLFKGRGEHPKAGLLKARIFPEELTVNLSTQAPVPQCKL 217 Query: 377 PGHNWGKIIHNSCVTWLAGWKDSI--TGGYKYVWLSAESAFKGMSDHAKFE 523 PGH+WGKI+H + VTWL + DS +KYV +A S FK M+D K+E Sbjct: 218 PGHSWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYE 268 [193][TOP] >UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus norvegicus RepID=UPI0001B7BF13 Length = 760 Score = 131 bits (330), Expect = 2e-29 Identities = 63/174 (36%), Positives = 105/174 (60%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 278 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 332 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D +E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 333 KLLKEYGFCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445 [194][TOP] >UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5FAF Length = 573 Score = 131 bits (330), Expect = 2e-29 Identities = 68/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ + + Sbjct: 86 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 139 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E +GNFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 140 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 199 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S KG D K+E Sbjct: 200 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 253 [195][TOP] >UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F97 Length = 790 Score = 131 bits (330), Expect = 2e-29 Identities = 68/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ + + Sbjct: 318 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 371 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E +GNFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 372 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 431 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S KG D K+E Sbjct: 432 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 485 [196][TOP] >UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F96 Length = 767 Score = 131 bits (330), Expect = 2e-29 Identities = 68/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ + + Sbjct: 280 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 333 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E +GNFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 334 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 393 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S KG D K+E Sbjct: 394 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [197][TOP] >UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE Length = 469 Score = 131 bits (330), Expect = 2e-29 Identities = 67/174 (38%), Positives = 103/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 271 FFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKEENE 325 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++++ ++D +E + NFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 326 RILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKH 385 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 386 P-TPPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 438 [198][TOP] >UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE Length = 758 Score = 131 bits (330), Expect = 2e-29 Identities = 67/174 (38%), Positives = 103/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 271 FFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKEENE 325 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++++ ++D +E + NFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 326 RILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKH 385 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PG W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 386 P-TPPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 438 [199][TOP] >UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica RepID=UPI0000F2B3E5 Length = 916 Score = 131 bits (329), Expect = 3e-29 Identities = 66/175 (37%), Positives = 103/175 (58%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + IT+L KCDF++I + K ++E + Q + E K + E Sbjct: 429 FFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF-----KAQSEARKQMSKEEKLKIKEEN 482 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ +++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A Sbjct: 483 ERLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAK 542 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 543 VPP-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 596 [200][TOP] >UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0 Length = 758 Score = 131 bits (329), Expect = 3e-29 Identities = 63/174 (36%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 271 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 325 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 326 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 385 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 386 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 438 [201][TOP] >UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA Length = 969 Score = 131 bits (329), Expect = 3e-29 Identities = 66/175 (37%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + IT LEKC+F + A+ + AE+ + E K A +A Sbjct: 503 FFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEI-----AEQNRNRSKEEKAALKAAN 556 Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 E++ +++ + ++DG +E +GNF++EP LF GRG+HP G VKRR+ PEDV +N ++ Sbjct: 557 EQLTKEYGICVIDGHKEKIGNFKIEPPGLFRGRGEHPKMGLVKRRVMPEDVIINCSQDSK 616 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IP P PG W ++ H++ V+WLA W +++ G KY+ L+ S KG D K+E Sbjct: 617 IPS-PPPGRRWKEVRHDNTVSWLASWVENVQGQVKYIMLNPSSKLKGEKDWQKYE 670 [202][TOP] >UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT Length = 767 Score = 131 bits (329), Expect = 3e-29 Identities = 63/174 (36%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 280 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 334 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 335 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [203][TOP] >UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE Length = 767 Score = 131 bits (329), Expect = 3e-29 Identities = 63/174 (36%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 280 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 334 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 335 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P PGH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [204][TOP] >UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU Length = 767 Score = 130 bits (328), Expect = 4e-29 Identities = 67/175 (38%), Positives = 105/175 (60%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + +K IT L KC+F+ + + K ++E + Q + E K+ + + Sbjct: 280 FFKDWRKEMTSEEKSK-ITDLNKCNFAGMNDYF-----KAQSEARKQMSKEEKQKIKEDN 333 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 ER+ Q + ++D +E +GNFR+EP LF GRGDHP G +KRRI+PED+ +N ++ Sbjct: 334 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 393 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S KG D K+E Sbjct: 394 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447 [205][TOP] >UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1 RepID=A9A2H9_NITMS Length = 551 Score = 130 bits (328), Expect = 4e-29 Identities = 82/178 (46%), Positives = 103/178 (57%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK----KAEKKAQTTAERKEAR 169 F ADF L D+KF K+ S E DFS ++ EK K K EKKA A+RKE R Sbjct: 62 FTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEMMTKEEKKA-IAAKRKELR 117 Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349 E E ++ VA++DG+E VGN+ EP +F+GRG+HPL G+ K R+ +DVTLNLG Sbjct: 118 E---ELKSKYGVAVMDGKEVEVGNYMAEPPGIFIGRGEHPLRGRWKPRVTAKDVTLNLGK 174 Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 A +PE WGKIIH+ WLA W D +T KYVWLS S K D K+E Sbjct: 175 EAKVPE-----GKWGKIIHDKDSMWLASWMDFLTQKRKYVWLSDSSDLKQGRDKEKYE 227 [206][TOP] >UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE Length = 596 Score = 130 bits (326), Expect = 7e-29 Identities = 73/171 (42%), Positives = 101/171 (59%), Gaps = 5/171 (2%) Frame = +2 Query: 26 LADTKFAKVITSLEKCDFSRIEAHLEDEKA---KKKAEKKAQTTAERKEAREAEAERVRQ 196 L TKF L+K DF++I+ +LE ++ K E+K Q ER + R Sbjct: 107 LMQTKFEGF--QLDKADFTKIKEYLEQQRLLRLNKSDEQKKQEKLERDQ-------RELF 157 Query: 197 FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPV 376 + ALVDG E VGN+ +E LF GRG+HP G +K RI PE++T+NL AP+P+C + Sbjct: 158 YGYALVDGCLERVGNYTLEQPTLFKGRGEHPKAGLLKARIFPEELTVNLSTQAPVPQCKL 217 Query: 377 PGHNWGKIIHNSCVTWLAGWKDSI--TGGYKYVWLSAESAFKGMSDHAKFE 523 PGH+WGKI+H + VTWL + DS +KYV +A S FK M+D K+E Sbjct: 218 PGHSWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYE 268 [207][TOP] >UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE Length = 966 Score = 129 bits (325), Expect = 9e-29 Identities = 67/174 (38%), Positives = 99/174 (56%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + ++ K I L+KC+F + H + + K Q A KE EA Sbjct: 485 FFKDWRKSMTSSEREK-IKDLKKCNFRSMHKHFAEISEANRNRTKEQKLA-LKEQNEA-- 540 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 ++++ +DG +E +GNFR+EP LF GRG+HP G VKRR+ PEDV +N G + Sbjct: 541 -LMKEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMVKRRVMPEDVIINCGKESVW 599 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P+ P GH W ++ H++ V+WLA W +++ G KYV L+ S KG D K+E Sbjct: 600 PKAP-EGHRWKEVRHDNSVSWLASWTENVQGQVKYVMLNPSSKLKGEKDWQKYE 652 [208][TOP] >UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI00005A45B7 Length = 1004 Score = 129 bits (324), Expect = 1e-28 Identities = 62/174 (35%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 517 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 571 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 572 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 631 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 632 PS-PPTGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 684 [209][TOP] >UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294 Length = 786 Score = 129 bits (324), Expect = 1e-28 Identities = 67/176 (38%), Positives = 102/176 (57%), Gaps = 2/176 (1%) Frame = +2 Query: 2 FFADFRA-LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178 FF D++ + AD + +IT+L KCDF+ + + K+++E + T E K+ + E Sbjct: 297 FFKDWKKEMTADER--NLITNLGKCDFNAMSQYF-----KEQSEARKNMTKEEKQKIKEE 349 Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355 ER+ Q + ++D E + NFR+EP LF GRGDHP GK+K+RI PED+ +N ++ Sbjct: 350 NERLLQEYGFCVMDNHRERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDS 409 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W ++ H+ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 410 KYPVAPA-GHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 464 [210][TOP] >UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30 Length = 752 Score = 129 bits (324), Expect = 1e-28 Identities = 62/174 (35%), Positives = 104/174 (59%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + + +IT+L KCDF+++ + KA+ +A K+ + E+ + +E Sbjct: 265 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 319 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++++ ++D E + NF++EP LF GRG+HP G +KRRI PED+ +N +A + Sbjct: 320 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 379 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W ++ H++ VTWL W ++I G KY+ L+ S KG D K+E Sbjct: 380 PS-PPTGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 432 [211][TOP] >UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG Length = 806 Score = 129 bits (324), Expect = 1e-28 Identities = 72/193 (37%), Positives = 105/193 (54%), Gaps = 19/193 (9%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAE------RKE 163 FF D+R + + AK IT L+KCDFS + + + + +KA K + R+ Sbjct: 246 FFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTEARKAMTKEEKLVSPHPHSCRRR 304 Query: 164 AREA------------EAERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKV 304 R A E ER+ +QF ++D +E + NFR+EP LF GRGDHP G + Sbjct: 305 LRAAGFIPSAFQKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGML 364 Query: 305 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAE 484 KRRI+PED+ +N ++ PE P PG W ++ H++ VTWL W ++I G KY+ L+ Sbjct: 365 KRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPS 423 Query: 485 SAFKGMSDHAKFE 523 S KG D K+E Sbjct: 424 SRIKGEKDWQKYE 436 [212][TOP] >UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni RepID=C4Q6C8_SCHMA Length = 587 Score = 129 bits (324), Expect = 1e-28 Identities = 62/174 (35%), Positives = 101/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+ + + + + I SL KCDF + + K E+K +T E+++ +E Sbjct: 199 FFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEERKNRTKEEKQKIKEENL 253 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ ++DG ++ +GNFR+EP LF GRG+HP G +K+RI PEDV +N ++ + Sbjct: 254 QIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKV 313 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W ++ H++ VTWLA W ++I +KY+ L+ S KG D K+E Sbjct: 314 P-APPKGHKWKEVRHDNSVTWLACWTENIQNSFKYIMLNPSSRLKGEKDWKKYE 366 [213][TOP] >UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni RepID=C4Q6C7_SCHMA Length = 652 Score = 129 bits (324), Expect = 1e-28 Identities = 62/174 (35%), Positives = 101/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+ + + + + I SL KCDF + + K E+K +T E+++ +E Sbjct: 199 FFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEERKNRTKEEKQKIKEENL 253 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ ++DG ++ +GNFR+EP LF GRG+HP G +K+RI PEDV +N ++ + Sbjct: 254 QIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKV 313 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P GH W ++ H++ VTWLA W ++I +KY+ L+ S KG D K+E Sbjct: 314 P-APPKGHKWKEVRHDNSVTWLACWTENIQNSFKYIMLNPSSRLKGEKDWKKYE 366 [214][TOP] >UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva RepID=Q4N5U3_THEPA Length = 1003 Score = 129 bits (323), Expect = 2e-28 Identities = 71/156 (45%), Positives = 96/156 (61%), Gaps = 3/156 (1%) Frame = +2 Query: 62 LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 241 L DFS I+ HLEDEK KKK K+ K ++ +A+R +F ALVD E V + Sbjct: 415 LTDVDFSLIKTHLEDEKQKKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSS 469 Query: 242 FRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNS 412 ++EP LF GRG HP G +K R+ P+DV LNL +AP+P+ GH+W I H++ Sbjct: 470 NKLEPPGLFKGRGLHPKQGLLKARMFPKDVILNLSKDAPVPKVSNFQREGHSWKDIYHDN 529 Query: 413 CVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 VTWLA +KDSI +KY++LSA+S FKG D K+ Sbjct: 530 SVTWLAYYKDSINDQFKYMYLSAQSKFKGFHDFLKY 565 [215][TOP] >UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7 Length = 839 Score = 127 bits (320), Expect = 4e-28 Identities = 71/167 (42%), Positives = 101/167 (60%), Gaps = 3/167 (1%) Frame = +2 Query: 32 DTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVA 208 +TK K I++ + DF I+ HL K + EK +T E++E ++ E+ +T A Sbjct: 234 ETKLKKGDISNFKFIDFMPIKDHL----LKLREEKLNKTKEEKEEEKKMRMEKELPYTYA 289 Query: 209 LVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPG 382 LVD E + + + EP LF GRG+HP G +K+RI PEDV +N+ +AP+P + G Sbjct: 290 LVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDNMCG 349 Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 HNWG I H++ VTWLA +KDSI KY +LSA+S FKG D K+E Sbjct: 350 HNWGDIYHDNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDLMKYE 396 [216][TOP] >UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI Length = 638 Score = 127 bits (320), Expect = 4e-28 Identities = 69/174 (39%), Positives = 98/174 (56%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DFR L + K+I KC+F I + E K+ A K + A+RK+ Sbjct: 141 FFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNKRLAATKEEKLAKRKKNEAF-- 197 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 V ++ LVDG E + NFR+EP LF GRGDHP G +KRR+Q D+ +N G ++ I Sbjct: 198 --VNKYGFCLVDGHRERISNFRLEPPGLFRGRGDHPKMGMIKRRVQACDIIINCGRDSKI 255 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 P P G W ++ H++ VTWLA W D++ G KY+ L++ S + SDH K+E Sbjct: 256 P-MPPRGQMWKEVRHDNTVTWLASWVDNVQGQSKYIILNSWSKIRCESDHNKYE 308 [217][TOP] >UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia guttata RepID=UPI000194BDF0 Length = 662 Score = 127 bits (319), Expect = 5e-28 Identities = 64/175 (36%), Positives = 101/175 (57%), Gaps = 1/175 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+R + + ++I L+KCDF I + ++ +K K E K+ + EA Sbjct: 175 FFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEKNEARKGLPK-----EEKQKLKEEA 228 Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358 +++++ + ++DG E +GNF+ EP LF GRG+HP G +K+RI PEDV +N ++ Sbjct: 229 DKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGEHPKMGMLKKRIMPEDVIINCSKDSK 288 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 IPE P GH W ++ ++ VTWLA W ++I KY+ L+ S KG D K+E Sbjct: 289 IPE-PPEGHKWKEVRFDNTVTWLASWTENIQNTLKYIMLNPSSKLKGEKDWEKYE 342 [218][TOP] >UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata RepID=Q4UDP8_THEAN Length = 999 Score = 127 bits (319), Expect = 5e-28 Identities = 70/156 (44%), Positives = 96/156 (61%), Gaps = 3/156 (1%) Frame = +2 Query: 62 LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 241 L DFS I+ HLE+EK KKK K+ K ++ +A+R +F ALVD E V + Sbjct: 416 LSDADFSLIKNHLEEEKQKKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSS 470 Query: 242 FRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNS 412 ++EP LF GRG HP G +K R+ P+DV LNL +AP+P+ GH+W I H++ Sbjct: 471 NKLEPPGLFKGRGLHPKQGLLKSRMFPKDVILNLSKDAPVPKVTNFQREGHSWKDIYHDN 530 Query: 413 CVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 VTWLA +KDSI +KY++LSA+S FKG D K+ Sbjct: 531 SVTWLAYYKDSINDQFKYMYLSAQSKFKGFHDFLKY 566 [219][TOP] >UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH Length = 713 Score = 127 bits (319), Expect = 5e-28 Identities = 69/173 (39%), Positives = 98/173 (56%), Gaps = 20/173 (11%) Frame = +2 Query: 65 EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTV-ALVDGREETVGN 241 +K DF+ I+ HLE++K +K K E K + + ER+ + A++DG E VG Sbjct: 213 DKFDFTPIKIHLEEQKEIRKNRSK-----EEKNQEKQKKERLSDYYAGAILDGFREKVGQ 267 Query: 242 FRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVP-------------- 379 F +EP LF GRG+HP G +K RIQPE V +N+ +AP+P+C VP Sbjct: 268 FMIEPPTLFKGRGEHPKMGMMKGRIQPEAVVINISKDAPVPKCSVPDCIHICRQIFNEFP 327 Query: 380 ----GHNWGKIIHNSCVTWLAGWK-DSITGGYKYVWLSAESAFKGMSDHAKFE 523 GH W +I+H VTWLA +K DS+ +KY++LSAES K +D K+E Sbjct: 328 KKQLGHGWSEIVHKQDVTWLASYKDDSVKKQHKYIFLSAESKLKAENDKKKYE 380 [220][TOP] >UniRef100_UPI000180B1AE PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Ciona intestinalis RepID=UPI000180B1AE Length = 482 Score = 127 bits (318), Expect = 6e-28 Identities = 60/157 (38%), Positives = 95/157 (60%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232 IT L KC+F + ++ + +K E+KA++ E++E ++ + +F DG E Sbjct: 10 ITDLGKCNFRDVCSYFQ----QKSEERKARSKEEKQEEKKKNEALIEEFGFCDWDGHREK 65 Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNS 412 +GNFR+EP LF GRG+HP GK+K+RI PE++T+N N+ IP+ P GH W ++ H++ Sbjct: 66 IGNFRLEPPGLFRGRGNHPKMGKLKKRIIPENITINCSKNSKIPK-PPAGHKWKEVRHDN 124 Query: 413 CVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 VTWL W +++ KY+ L+ S KG D K+E Sbjct: 125 AVTWLVSWTENVQNQNKYIMLNPSSRVKGEKDWQKYE 161 [221][TOP] >UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio RepID=UPI0001A2BD10 Length = 349 Score = 127 bits (318), Expect = 6e-28 Identities = 66/151 (43%), Positives = 93/151 (61%), Gaps = 1/151 (0%) Frame = +2 Query: 47 KVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGR 223 K+IT+L KCDF+ I + +K EKK T KE + EA R+ +F L+DG Sbjct: 208 KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----KEVLKDEAARLMEEFGYCLLDGH 259 Query: 224 EETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKII 403 E +GNF++EP LF GRG+HP G++K+RIQPEDV +N ++ IPE P GH W ++ Sbjct: 260 REKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCSKDSKIPE-PPAGHKWKRVQ 318 Query: 404 HNSCVTWLAGWKDSITGGYKYVWLSAESAFK 496 H++ VTWLA W ++I KY+ L+ S K Sbjct: 319 HDNTVTWLASWLENIQKRPKYIMLNPSSKLK 349 [222][TOP] >UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1 Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO Length = 886 Score = 126 bits (317), Expect = 8e-28 Identities = 67/159 (42%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232 I++ + DF I+ HL K + E+ +T E++E ++ E+ +T ALVD E Sbjct: 294 ISNFKFIDFMTIKEHL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREK 349 Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406 + + + EP LF GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H Sbjct: 350 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYH 409 Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA +KDSI KY +LSA+S FKG D K+E Sbjct: 410 DNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 448 [223][TOP] >UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L6G4_PLAKH Length = 924 Score = 126 bits (317), Expect = 8e-28 Identities = 67/159 (42%), Positives = 97/159 (61%), Gaps = 2/159 (1%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232 I++ + DF I+ HL K + EK +T E++E ++ +E+ T ALVD E Sbjct: 276 ISNFQFIDFMPIKDHL----VKLREEKLNRTKEEKEEEKKLRSEKELPHTYALVDWIREK 331 Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406 + + + EP LF GRG+HP G +K+RI PEDV +N+ +AP+P + GH+WG I H Sbjct: 332 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYGDMCGHSWGDIYH 391 Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA +KDSI KY +LSA+S FKG D K+E Sbjct: 392 DNKVTWLAYYKDSINDQLKYTFLSAQSKFKGYKDFLKYE 430 [224][TOP] >UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F98 Length = 790 Score = 125 bits (315), Expect = 1e-27 Identities = 67/189 (35%), Positives = 106/189 (56%), Gaps = 15/189 (7%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKKKAEKKA---------- 139 FF D+R + + +K IT L KC+F+ + +A E K K EK+ Sbjct: 253 FFKDWRKEMTSEEKSK-ITDLNKCNFAGMNEYFKAQSEARKQMSKEEKQVSLHSITCSPA 311 Query: 140 -QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRI 316 +T++ + +E ++++ ++D +E +GNFR+EP LF GRGDHP G +KRRI Sbjct: 312 LKTSSHLNKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRI 371 Query: 317 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFK 496 +PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G KY+ L+ S K Sbjct: 372 RPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIK 430 Query: 497 GMSDHAKFE 523 G D K+E Sbjct: 431 GEKDWQKYE 439 [225][TOP] >UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi RepID=Q4XMK5_PLACH Length = 429 Score = 125 bits (315), Expect = 1e-27 Identities = 67/159 (42%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232 I++ + DF I+ HL K + E+ +T E++E ++ E+ +T ALVD E Sbjct: 269 ISNFKFIDFMTIKEHL----IKLRDERLNKTKEEKEEDKKIRMEKELPYTFALVDWIREK 324 Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406 + + + EP LF GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H Sbjct: 325 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYH 384 Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA +KDSI KY +LSA+S FKG D K+E Sbjct: 385 DNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 423 [226][TOP] >UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO Length = 701 Score = 124 bits (312), Expect = 3e-27 Identities = 66/157 (42%), Positives = 94/157 (59%), Gaps = 3/157 (1%) Frame = +2 Query: 59 SLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVG 238 +L+ CDFS I AHL+ E+ KKK +K+ K +E A++ + ALVD E VG Sbjct: 195 TLKDCDFSEIRAHLDMEREKKKEQKEYY-----KALKEETAKKEHPYCYALVDWIREKVG 249 Query: 239 NFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPV---PGHNWGKIIHN 409 + R+EP LF GRG HP G +K R P V LNL +AP+P+ + GH W I H+ Sbjct: 250 SNRMEPPGLFKGRGLHPKQGLLKGRTFPHSVVLNLSKDAPVPKVSMFERQGHGWSDIFHD 309 Query: 410 SCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 S VTWLA ++D++ KY++ +A+S FKG+ D K+ Sbjct: 310 SSVTWLAYYRDTVNDQTKYMYPAAQSKFKGLHDFLKY 346 [227][TOP] >UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax RepID=A5KB33_PLAVI Length = 931 Score = 124 bits (311), Expect = 4e-27 Identities = 66/159 (41%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232 I++ + DF I+ HL K + EK +T E++E ++ +E+ +T ALVD E Sbjct: 276 ISNFKFIDFMPIKDHL----VKLREEKLNRTKEEKEEEKKLRSEKELPYTYALVDWIREK 331 Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406 + + + EP LF GRG+HP G +K+RI PEDV +N+ +AP+P + GH WG H Sbjct: 332 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDDMCGHCWGDTYH 391 Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA +KDSI KY +LSA+S FKG D K+E Sbjct: 392 DNKVTWLAYYKDSINDQLKYTFLSAQSKFKGYKDFLKYE 430 [228][TOP] >UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei RepID=Q4YYG2_PLABE Length = 805 Score = 124 bits (310), Expect = 5e-27 Identities = 66/159 (41%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Frame = +2 Query: 53 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232 I++ + DF I+ +L K + E+ +T E++E ++ E+ +T ALVD E Sbjct: 239 ISNFKFIDFMTIKENL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREK 294 Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406 + + + EP LF GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H Sbjct: 295 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYH 354 Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 ++ VTWLA +KDSI KY +LSA+S FKG D K+E Sbjct: 355 DNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 393 [229][TOP] >UniRef100_UPI0000E48333 PREDICTED: similar to topoisomerase I alpha isoform 3, partial n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000E48333 Length = 440 Score = 116 bits (291), Expect = 8e-25 Identities = 55/121 (45%), Positives = 75/121 (61%) Frame = +2 Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340 E + E +++ DG +E +GNFRVEP +LF GRG+HP G++K+RI PEDV +N Sbjct: 1 ENKRKNEEIQKEYGFCSFDGHKEKIGNFRVEPPSLFRGRGEHPKQGQLKKRIGPEDVIIN 60 Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520 ++ P P GH W K+IH + VTWLA W ++I G KYV L+ S KG D AK+ Sbjct: 61 CSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQGAIKYVMLNPSSRIKGEKDWAKY 119 Query: 521 E 523 E Sbjct: 120 E 120 [230][TOP] >UniRef100_B3T4E9 Putative eukaryotic DNA topoisomerase I, catalytic core n=1 Tax=uncultured marine crenarchaeote HF4000_ANIW133O4 RepID=B3T4E9_9ARCH Length = 563 Score = 116 bits (291), Expect = 8e-25 Identities = 61/167 (36%), Positives = 92/167 (55%), Gaps = 6/167 (3%) Frame = +2 Query: 41 FAKVITS-LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVA--- 208 FAK + +S I+ L + K+ E+K T E K+A + + +R+ A Sbjct: 73 FAKTFNGKFKNLQYSDIDFSLAHQLVDKEKEEKELLTKEDKKALAIKRKEIREEMKAKYG 132 Query: 209 --LVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382 ++DG+E +GN+ EP +F+GRG+HP+ G+ K R+ +DVTLNLG A IPE Sbjct: 133 NGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLNLGKEAKIPEA---- 188 Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 WGKI+H+ W+A W D +T KYVWL+ + K D AK++ Sbjct: 189 -KWGKIVHDRNSMWIASWMDILTQKRKYVWLADTAGIKQEMDQAKYD 234 [231][TOP] >UniRef100_B3TAG0 Putative eukaryotic DNA topoisomerase I, catalytic core n=1 Tax=uncultured marine crenarchaeote HF4000_APKG8D22 RepID=B3TAG0_9ARCH Length = 563 Score = 115 bits (289), Expect = 1e-24 Identities = 61/167 (36%), Positives = 92/167 (55%), Gaps = 6/167 (3%) Frame = +2 Query: 41 FAKVITS-LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVA--- 208 FAK + +S I+ L + K+ E+K T E K+A + + +R+ A Sbjct: 73 FAKTFNGKFKNLQYSDIDFSLAYQLVDKEKEEKELLTKEDKKALAIKRKEIREEMKAKYG 132 Query: 209 --LVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382 ++DG+E +GN+ EP +F+GRG+HP+ G+ K R+ +DVTLNLG A IPE Sbjct: 133 NGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLNLGKEAKIPEA---- 188 Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 WGKI+H+ W+A W D +T KYVWL+ + K D AK++ Sbjct: 189 -KWGKIVHDRNSMWIASWMDILTQKRKYVWLADTAGIKQEMDQAKYD 234 [232][TOP] >UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2) (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD Length = 620 Score = 114 bits (284), Expect = 5e-24 Identities = 61/174 (35%), Positives = 101/174 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF+D+R + + +VI L++CDF+ I H D K A +KA + E+++ +E E Sbjct: 70 FFSDWRKEMTAEE-GRVIKHLDRCDFTEIHRHSVD----KTASQKALSREEKQKLKEEEE 124 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++F +++DG E +G+F+ EP ++ GRGDHP ++KRR+ PEDV +N ++ + Sbjct: 125 KLQQEFGCSILDGHREKIGSFKTEPWSV-RGRGDHPKMERLKRRVLPEDVVINCSRDSTV 183 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 PE P G W ++ + V WLA W +++ KYV L+ KG D K+E Sbjct: 184 PE-PPAGPQWKEVGCDCTVMWLAAWTENVQNFIKYVTLNPGCKLKGERDWGKYE 236 [233][TOP] >UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum RepID=A0RU10_CENSY Length = 519 Score = 110 bits (276), Expect = 5e-23 Identities = 61/153 (39%), Positives = 87/153 (56%), Gaps = 3/153 (1%) Frame = +2 Query: 74 DFSRIEAHLEDEKAKKKA---EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244 DFS ++ EK KK E+K + A+RKE RE + + +A++DG+E + ++ Sbjct: 80 DFSEAYRLVDMEKDKKDMMTKEEKKEIAAKRKEIREGLKAK---YGIAVMDGKEVEIASY 136 Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTW 424 EP +F+GRG HPL GK KRRI P+DV LN+G A P PG W KI+H W Sbjct: 137 MAEPPGIFIGRGKHPLRGKWKRRIGPQDVVLNMGTKAKAP----PG-KWKKIVHEKDGIW 191 Query: 425 LAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523 +A W D++ KYVWL+ + K D +K+E Sbjct: 192 IAKWTDNLVKKDKYVWLADTAGLKQERDRSKYE 224 [234][TOP] >UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA Length = 790 Score = 108 bits (271), Expect = 2e-22 Identities = 68/178 (38%), Positives = 102/178 (57%), Gaps = 4/178 (2%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 F +D+R +L + +I +LE CDF+ I + EK KKK +T E+K +E + Sbjct: 276 FMSDWRKILGEKH---IIQNLEDCDFTPIYEWHQREKEKKKQ----MSTDEKKAIKEGKD 328 Query: 182 E-RVRQFTVALVDGRE-ETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPE-DVTLNLGPN 352 E R ++ A+VDG E VGNFRV + + +VK+ + + D+T+N+G + Sbjct: 329 ETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWRASKDPQVKKNVYSQIDITINIGKD 388 Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523 APIPE P+PG W +I H++ VTWLA W D I +KYV+L+A S+ KG K+E Sbjct: 389 APIPEPPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGKVTREKYE 446 [235][TOP] >UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum RepID=Q5C1T3_SCHJA Length = 330 Score = 108 bits (270), Expect = 2e-22 Identities = 52/145 (35%), Positives = 85/145 (58%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF D+ + + + + I SL KCDF + + K E+K +T E+++ +E Sbjct: 191 FFHDWVKTMNEEE-RRTIKSLSKCDFQEMHQYF----LKLSEERKNRTKEEKQKIKEENL 245 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + ++ ++DG ++ +GNFR+EP LF GRG+HP G +K+RI PEDV +N ++ + Sbjct: 246 QIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKV 305 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGW 436 P P GH W ++ H++ VTWLA W Sbjct: 306 P-APPKGHKWKEVRHDNSVTWLACW 329 [236][TOP] >UniRef100_Q56XA9 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q56XA9_ARATH Length = 396 Score = 88.2 bits (217), Expect = 3e-16 Identities = 39/77 (50%), Positives = 55/77 (71%), Gaps = 1/77 (1%) Frame = +2 Query: 296 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVW 472 G++K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D I +KYV+ Sbjct: 1 GELKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVF 60 Query: 473 LSAESAFKGMSDHAKFE 523 L A S+ KG+SD K+E Sbjct: 61 LGAGSSLKGLSDKEKYE 77 [237][TOP] >UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI Length = 557 Score = 86.3 bits (212), Expect = 1e-15 Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 2/158 (1%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR-EAE 178 FF DFR+ L+ + TS + C+F +I +LE E++EAR + E Sbjct: 129 FFKDFRSCLSVEQRLH-FTSFDLCNFQKIHQYLE----------------EQQEARSQQE 171 Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLT-GKVKRRIQPEDVTLNLGPNA 355 E ++ +DG + FR++P L R + LT G ++ R+ PED+ +N A Sbjct: 172 LEEDERYGYCYIDGERHRINQFRIKPPGLCCPRKGYSLTMGMIRPRVLPEDIMINCDEYA 231 Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYV 469 P P PGH W +++H+ V+WL W D ++G YV Sbjct: 232 E-PPAPPPGHRWRQVVHDRSVSWLYSWHDLVSGNTYYV 268 [238][TOP] >UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187E0BD Length = 265 Score = 84.7 bits (208), Expect = 3e-15 Identities = 48/116 (41%), Positives = 67/116 (57%), Gaps = 2/116 (1%) Frame = +2 Query: 2 FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175 FF D+ +L D + +T +KCDF + + E EKAKKKA + AE+KE ++ Sbjct: 145 FFEDWLKVLQDHPPRNGIKVTDFDKCDFRPMYEYFEAEKAKKKA----MSAAEKKEIKKQ 200 Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNL 343 + E ++T +DGR+E VGNFRVEP LF GRG+HP G +K P + L L Sbjct: 201 KDEAEAKYTHCFLDGRKEKVGNFRVEPPGLFRGRGEHPKKGSLKVIGSPSLIALGL 256 [239][TOP] >UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO Length = 555 Score = 77.8 bits (190), Expect = 4e-13 Identities = 48/164 (29%), Positives = 76/164 (46%), Gaps = 1/164 (0%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +FR+ L++ + + IT E C+F I +LE +R++ +E A Sbjct: 126 FFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLE---------------CQREDEKERIA 169 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLT-GKVKRRIQPEDVTLNLGPNAP 358 E + + LVDG + FR+ L R T G ++ R+ PEDV +N N Sbjct: 170 EENKLYGYCLVDGESRRITQFRISRPGLCCPRHGFSTTMGTIRPRVLPEDVVINCDENEE 229 Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESA 490 P P GH W ++H+ V W+ W D +TG + + ES+ Sbjct: 230 -PPAPPCGHLWAAVVHDRTVRWVYAWNDIVTGCMHHAYPRNESS 272 [240][TOP] >UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7 Length = 879 Score = 73.9 bits (180), Expect = 6e-12 Identities = 35/73 (47%), Positives = 45/73 (61%) Frame = +2 Query: 305 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAE 484 K+RI PEDV +N ++ P P GH W K+IH + VTWLA W ++I G KYV L+ Sbjct: 488 KQRIGPEDVIINCSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQGAIKYVMLNPS 546 Query: 485 SAFKGMSDHAKFE 523 S KG D AK+E Sbjct: 547 SRIKGEKDWAKYE 559 [241][TOP] >UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN Length = 240 Score = 72.0 bits (175), Expect = 2e-11 Identities = 48/155 (30%), Positives = 74/155 (47%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF DF++ L+ + I S E CDF++I +++ ++ ++K T R Sbjct: 80 FFKDFQSHLSRA-LRRQILSFELCDFTKIAFYIQGQQG---VQRKLMTPMMRNH------ 129 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361 + +DG+ V +F + +L+ G P G VK RIQPEDV +N N Sbjct: 130 -----YGYCTIDGKRHRVPHFSFDGPSLYRRSG--PKYGMVKPRIQPEDVNINSQENGA- 181 Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKY 466 P P GH W +IH+ V WL W D+++G Y Sbjct: 182 PGAP-DGHTWKSVIHDRRVDWLWSWTDALSGRVHY 215 [242][TOP] >UniRef100_B4E061 cDNA FLJ51170, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4E061_HUMAN Length = 477 Score = 69.3 bits (168), Expect = 2e-10 Identities = 34/76 (44%), Positives = 46/76 (60%) Frame = +2 Query: 296 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWL 475 G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W +SI KY+ L Sbjct: 2 GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESIQNSIKYIML 60 Query: 476 SAESAFKGMSDHAKFE 523 + S KG + KFE Sbjct: 61 NPCSKLKGETAWQKFE 76 [243][TOP] >UniRef100_UPI0001AE6F94 UPI0001AE6F94 related cluster n=1 Tax=Homo sapiens RepID=UPI0001AE6F94 Length = 477 Score = 68.9 bits (167), Expect = 2e-10 Identities = 33/76 (43%), Positives = 46/76 (60%) Frame = +2 Query: 296 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWL 475 G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W +S+ KY+ L Sbjct: 2 GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIML 60 Query: 476 SAESAFKGMSDHAKFE 523 + S KG + KFE Sbjct: 61 NPCSKLKGETAWQKFE 76 [244][TOP] >UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major RepID=Q7YXA0_LEIMA Length = 200 Score = 67.0 bits (162), Expect = 7e-10 Identities = 45/102 (44%), Positives = 55/102 (53%) Frame = +2 Query: 2 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181 FF +R +L K I LE CDF I ++ KK + K + A KE ++AEA Sbjct: 105 FFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQREKKLSRTKEEKEAI-KEKQDAEA 161 Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVK 307 E R + DGR E V NFRVEP LF GRG HPL GK+K Sbjct: 162 EPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLK 200