AU196960 ( PFL097e09_r )

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[1][TOP]
>UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum
           RepID=TOP1_DICDI
          Length = 893

 Score =  175 bits (444), Expect = 1e-42
 Identities = 81/175 (46%), Positives = 116/175 (66%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF +F+ LL   +  +++  ++KCDFS I  HL+ +K ++KA  K     E K+A  AE 
Sbjct: 371 FFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKEQRKARSK-----EEKDAETAEK 424

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           +++++    A +DG +E VGN+ +EP  LFLGRG HP TG +K+RI P DVTLN+G    
Sbjct: 425 KKIQEKHGFATIDGFKEKVGNYMIEPPGLFLGRGQHPKTGMLKQRIMPSDVTLNIGEGEV 484

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP  P+PG  W +I+HN+ VTWLA W++S+ GG+KYVWL+  S  KG +D  KFE
Sbjct: 485 IPPSPIPGEKWKEIVHNNTVTWLAFWRESVNGGFKYVWLAPSSKIKGQADRKKFE 539

[2][TOP]
>UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum
           bicolor RepID=C5YGY1_SORBI
          Length = 921

 Score =  169 bits (429), Expect = 8e-41
 Identities = 86/176 (48%), Positives = 118/176 (67%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R +L       +I   E CDF+ I E HL     ++K +KK  TT E+K  RE +
Sbjct: 438 FFTDWRKILGKNH---IIKKFELCDFTPIYEWHL-----REKEKKKQMTTEEKKALREEK 489

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRIQP D+T+N+G  AP
Sbjct: 490 LKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIQPSDITINIGKGAP 549

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           +PECP+PG +W +I H++ VTWLA W D I+   +KYV+L+A S+ KG SD  K+E
Sbjct: 550 VPECPIPGESWKEIKHDNTVTWLAFWNDPISQKDFKYVFLAASSSLKGQSDKEKYE 605

[3][TOP]
>UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO
          Length = 910

 Score =  167 bits (424), Expect = 3e-40
 Identities = 85/175 (48%), Positives = 116/175 (66%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D++ +L       VI +LE CDFS I    + EK KKK      TT E+K  +E + 
Sbjct: 425 FFGDWKKILGKNH---VIQNLENCDFSPIYEWHQSEKEKKKQ----MTTEEKKALKEEKL 477

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A VDG++E VGNFRVEP  LF GRG+HP  GK+K+RI+P D+T+N+G +API
Sbjct: 478 KQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKDAPI 537

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECPVPG  W ++ H++ VTWLA W D I    +KYV+L+A S  KG+SD  K+E
Sbjct: 538 PECPVPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSTLKGLSDKEKYE 592

[4][TOP]
>UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI
          Length = 760

 Score =  167 bits (424), Expect = 3e-40
 Identities = 87/182 (47%), Positives = 120/182 (65%), Gaps = 8/182 (4%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+A+L ++  AK        I +  KCDFS + AH E    K + EKKA + AE+K
Sbjct: 196 FFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDMYAHFE----KMREEKKAMSAAEKK 251

Query: 161 EAREAEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTL 337
            A +AE +++ + F V L++GR+E VGNFR+EP  LF GRG HP TGK+KRR+ PE +T+
Sbjct: 252 -AIKAERDKIEEPFKVCLLNGRKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEQITI 310

Query: 338 NLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAK 517
           N+G   P+PE P  GH WG++ H++ V WLA W ++I    KYV  +A S+ KGMSD+ K
Sbjct: 311 NIGKGVPVPE-PPAGHKWGEVRHDNSVAWLAMWHENINNSIKYVLFAANSSLKGMSDYKK 369

Query: 518 FE 523
           FE
Sbjct: 370 FE 371

[5][TOP]
>UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group
           RepID=Q84ZL5_ORYSJ
          Length = 916

 Score =  167 bits (423), Expect = 4e-40
 Identities = 85/176 (48%), Positives = 118/176 (67%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R +L       VI   E CDF+ I E HL     ++K +KK  T+ E+K  +E +
Sbjct: 433 FFTDWRKILGKNH---VIKKFELCDFTPIYEWHL-----REKEKKKQMTSEEKKALKEEK 484

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRI+P D+T+N+G  AP
Sbjct: 485 LKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAP 544

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           IPECP+PG +W ++ H++ VTWLA W D I+   +KYV+L+A SA KG SD  K+E
Sbjct: 545 IPECPIPGESWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYE 600

[6][TOP]
>UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group
           RepID=A2YRB7_ORYSI
          Length = 916

 Score =  167 bits (423), Expect = 4e-40
 Identities = 85/176 (48%), Positives = 118/176 (67%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R +L       VI   E CDF+ I E HL     ++K +KK  T+ E+K  +E +
Sbjct: 433 FFTDWRKILGKNH---VIKKFELCDFTPIYEWHL-----REKEKKKQMTSEEKKALKEEK 484

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRI+P D+T+N+G  AP
Sbjct: 485 LKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIKPSDITINIGKGAP 544

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           IPECP+PG +W ++ H++ VTWLA W D I+   +KYV+L+A SA KG SD  K+E
Sbjct: 545 IPECPIPGESWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYE 600

[7][TOP]
>UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B7ZWU7_MAIZE
          Length = 574

 Score =  165 bits (418), Expect = 2e-39
 Identities = 84/176 (47%), Positives = 116/176 (65%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R +L       +I + E CDF+ I E HL     ++K  KK  TT E+K  RE +
Sbjct: 91  FFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLREDK 142

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRI P D+T+N+G  AP
Sbjct: 143 LKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRILPSDITINIGKGAP 202

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           +PECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 203 VPECPIPGESWKEVKHDNTVTWLAFWNDPINPKDFKYVFLAASSSLKGQSDKEKYE 258

[8][TOP]
>UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE
          Length = 904

 Score =  165 bits (417), Expect = 2e-39
 Identities = 84/176 (47%), Positives = 115/176 (65%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R +L       +I + E CDF+ I E HL     ++K  KK  TT E+K  RE  
Sbjct: 421 FFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLREDN 472

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRI P D+T+N+G  AP
Sbjct: 473 LKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRILPSDITINIGKGAP 532

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           +PECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 533 VPECPIPGESWKEVKHDNTVTWLAFWNDPINPKDFKYVFLAASSSLKGQSDKEKYE 588

[9][TOP]
>UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis
           RepID=B9SSQ1_RICCO
          Length = 891

 Score =  164 bits (416), Expect = 3e-39
 Identities = 85/175 (48%), Positives = 115/175 (65%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F+ D+R LL       VI  LE CDF+ I    E EK KKK      +T E+K  +E + 
Sbjct: 407 FWNDWRKLLGRNH---VIQKLEDCDFTPIYEWHEREKEKKKQ----MSTEEKKAQKEEKL 459

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
            +  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+K+RIQP D+T+N+G +API
Sbjct: 460 RQEEKYMWAIVDGVKEKVGNFRVEPPALFRGRGEHPKMGKLKKRIQPSDITINIGKDAPI 519

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 520 PECPIPGESWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 574

[10][TOP]
>UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4XZS7_CLAL4
          Length = 764

 Score =  163 bits (412), Expect = 8e-39
 Identities = 83/175 (47%), Positives = 111/175 (63%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L +     V IT  +KCDFS++ AH      K + EKK  + AE+   ++  
Sbjct: 204 FFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF----VKVREEKKNMSKAEKLRLKQER 259

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
                 +   L++GR E VGNF+VEP +LF GRG HP TGK+K+R+ PED+TLNLG  AP
Sbjct: 260 EALEEPYRTCLLNGRRENVGNFKVEPPSLFRGRGAHPKTGKLKKRVYPEDITLNLGIEAP 319

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP  P  GH WG+I H+  V WLA WK++I+  +KYV L+A S+ KG+SD  KFE
Sbjct: 320 IPPAP-EGHKWGEIRHDKSVVWLAMWKENISDSFKYVKLAANSSIKGISDMKKFE 373

[11][TOP]
>UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum
           RepID=Q94705_PHYPO
          Length = 1015

 Score =  162 bits (411), Expect = 1e-38
 Identities = 82/175 (46%), Positives = 113/175 (64%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F++DFR  L   +  KVI    K DF+ I  +L ++K     E KA  TAE K+A +AE 
Sbjct: 471 FWSDFRTYLTPEQ-KKVIKDFSKADFTHIHKYLVEQK-----ELKANRTAEEKKAEKAEK 524

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E++ Q +  A+++G  + + N+ +E   LFLGRG HP TG VK+RI+ ED+T+N+G   P
Sbjct: 525 EKLLQKYGFAMINGHRQRISNWAIERPGLFLGRGAHPKTGLVKKRIEAEDITINIGKGVP 584

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +PE P PGH W K++H+  V WLA WK++I  G+KYVWL A SA KG SD  KFE
Sbjct: 585 VPE-PPPGHKWCKVVHDDKVAWLAMWKENINNGFKYVWLHASSAVKGRSDMKKFE 638

[12][TOP]
>UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence
           n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI
          Length = 857

 Score =  162 bits (409), Expect = 2e-38
 Identities = 82/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F AD+R +L       VI  L+ CDF+ I    ++EK KKK      +T E+K  +E + 
Sbjct: 375 FMADWRKILGKNH---VIQRLDDCDFTPIYEWHQEEKEKKKQ----MSTEEKKTLKEEKL 427

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +   ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRI P D+T+N+G N+ I
Sbjct: 428 KLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIHPSDITINIGKNSQI 487

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 488 PECPIPGESWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 542

[13][TOP]
>UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST
          Length = 780

 Score =  162 bits (409), Expect = 2e-38
 Identities = 86/176 (48%), Positives = 116/176 (65%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  ++ +T  + V I   EK DFS+I AH E     K  E+K   T ++K+A + E
Sbjct: 218 FFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE-----KLREEKKLLTKDQKKAMKEE 272

Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
            ER+ + +   L +G +E VGNFRVEP  LF GRG HP TGK+KRR+ PE VTLN+G  A
Sbjct: 273 KERIEEPYKTCLFNGHKELVGNFRVEPPGLFRGRGAHPRTGKLKRRVYPEMVTLNIGAGA 332

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            IPE P PGH+WG+I +++ VTWLA W+++I   +KYV  +A S+ KG+SD  KFE
Sbjct: 333 KIPEAP-PGHSWGEIKNDNTVTWLAMWRENIADSFKYVRFAASSSIKGVSDFKKFE 387

[14][TOP]
>UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP
           RepID=B2WCA4_PYRTR
          Length = 905

 Score =  161 bits (407), Expect = 3e-38
 Identities = 87/181 (48%), Positives = 110/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A+L  T   K        I   EKCDF  I    + E+AKKKA   A+  A + 
Sbjct: 337 FFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKPIFEWFDAERAKKKALSAAEKKALKA 396

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E   AEA+    +   L DGR++ VGNFRVEP  LF GRG+HP TG+VK+R+ PE +T+N
Sbjct: 397 EKEAAEAD----YMYCLWDGRKQKVGNFRVEPPGLFRGRGEHPKTGRVKKRVMPEQITIN 452

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G NA +PE P  GH W +I H+   TWLA W+++I G YKYV L+A S  KG SD  KF
Sbjct: 453 IGENAKVPE-PPAGHRWKEIKHDHEGTWLAMWQENINGAYKYVMLAANSDIKGQSDFKKF 511

Query: 521 E 523
           E
Sbjct: 512 E 512

[15][TOP]
>UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC
          Length = 852

 Score =  160 bits (406), Expect = 4e-38
 Identities = 81/175 (46%), Positives = 112/175 (64%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R +L       VI +L+ CDF+ I      EK KKK      +T  ++  RE + 
Sbjct: 394 FMNDWRKILGKNH---VIQNLDDCDFTPIYERPSSEKEKKKQ----MSTKRKRPLREEKL 446

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+KRRI+P D+T+N+G  API
Sbjct: 447 KQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPNDITINIGKGAPI 506

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 507 PECPIPGERWKEVRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDKEKYE 561

[16][TOP]
>UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT
          Length = 927

 Score =  160 bits (406), Expect = 4e-38
 Identities = 81/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D++ +L        I +LE CDF  I    + EK KKK      TT E+K  +E + 
Sbjct: 443 FFSDWKKMLGKNH---TIQNLEDCDFGPIYEWHQQEKEKKKQ----MTTEEKKALKEDKL 495

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+K+RI+P D+T+N+G +API
Sbjct: 496 QQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPRDITINIGKDAPI 555

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ +++ VTWLA W D I    +KYV+L+A S  KG SD  K+E
Sbjct: 556 PECPIPGERWKEVRNDNTVTWLAFWIDPINQKEFKYVFLAASSTLKGQSDKEKYE 610

[17][TOP]
>UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa
           RepID=B9I1A0_POPTR
          Length = 860

 Score =  160 bits (405), Expect = 5e-38
 Identities = 82/175 (46%), Positives = 113/175 (64%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F+ D+R LL       VI  LE CDF+ I    + EK KKK      +T E+K  RE + 
Sbjct: 377 FWNDWRTLLGKNH---VIQKLEACDFNPIYEWHQKEKEKKKQ----MSTEEKKAVREEKL 429

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++   +  A+V+G +E VGNFRVEP  LF GRG+HP  GK+K RI+P D+T+N+G +API
Sbjct: 430 KQEEMYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKSRIRPSDITINIGKDAPI 489

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           P+CP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 490 PKCPIPGERWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 544

[18][TOP]
>UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5LJG7_9ALVE
          Length = 551

 Score =  160 bits (405), Expect = 5e-38
 Identities = 84/174 (48%), Positives = 112/174 (64%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F+ADF+A L     +K IT L+ CDF  I+ +L+    K+   KKA+T  E++  +EA+ 
Sbjct: 155 FWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD----KRSEAKKARTKEEKEAEKEAKR 209

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
                +T  +VD   E VGNFRVEP NLF GRGDHP  GK+K+ I PEDVT+N   +AP 
Sbjct: 210 LNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKMGKLKQYILPEDVTVNCAADAPA 269

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P CPVPGH +  ++H+  VTWLA + D+I    KYV+L+A S FKG SD  K+E
Sbjct: 270 PRCPVPGHAYKDVVHDPAVTWLAWFTDTINNQVKYVFLNAASGFKGQSDWLKYE 323

[19][TOP]
>UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5L755_9ALVE
          Length = 647

 Score =  160 bits (405), Expect = 5e-38
 Identities = 84/174 (48%), Positives = 112/174 (64%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F+ADF+A L     +K IT L+ CDF  I+ +L+    K+   KKA+T  E++  +EA+ 
Sbjct: 155 FWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD----KRSEAKKARTKEEKEAEKEAKR 209

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
                +T  +VD   E VGNFRVEP NLF GRGDHP  GK+K+ I PEDVT+N   +AP 
Sbjct: 210 LNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKMGKLKQYILPEDVTVNCAADAPA 269

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P CPVPGH +  ++H+  VTWLA + D+I    KYV+L+A S FKG SD  K+E
Sbjct: 270 PRCPVPGHAYKDVVHDPAVTWLAWFTDTINNQVKYVFLNAASGFKGQSDWLKYE 323

[20][TOP]
>UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG
          Length = 763

 Score =  160 bits (405), Expect = 5e-38
 Identities = 81/175 (46%), Positives = 116/175 (66%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF+DF+ ++ +   A V I S +KCDFS+I  H E +K+ KK+     T A+++E +  +
Sbjct: 202 FFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQKSLKKS----LTAAQKREIKSEK 257

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +   ++   L++GR E VGNFR+EP  LF GRG HP TG+VK+RI PEDV+LNL  +AP
Sbjct: 258 DKFEEKYKYCLLNGRRERVGNFRIEPPGLFRGRGSHPKTGRVKKRIYPEDVSLNLSEDAP 317

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP  P  GH W +I H++ V WLA W++++T   KYV  +A+S+ KG SD  KFE
Sbjct: 318 IPP-PPEGHQWKEIKHDNTVAWLATWRENVTNTVKYVLFAADSSLKGRSDFKKFE 371

[21][TOP]
>UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus
           RepID=A5E508_LODEL
          Length = 849

 Score =  160 bits (405), Expect = 5e-38
 Identities = 84/175 (48%), Positives = 113/175 (64%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF+ +L ++    V I   EK DFS+I A+ E    KK+ EKKA +  E+K  +E +
Sbjct: 289 FFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE----KKREEKKAMSREEKKRLKEEK 344

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
                 F   L++GR+E VGNFR+EP  LF GRG HP TGK+KRR++PE VTLNL     
Sbjct: 345 DRIEEPFKTCLLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVRPEQVTLNLSKGVK 404

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH+W ++ H++ VTWLA WK++I+  +KYV  +A S+ KG SD  KFE
Sbjct: 405 IPE-PPAGHHWAEVRHDNEVTWLAMWKENISDSFKYVRFAANSSVKGQSDFKKFE 458

[22][TOP]
>UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe
           RepID=TOP1_SCHPO
          Length = 814

 Score =  160 bits (405), Expect = 5e-38
 Identities = 74/174 (42%), Positives = 110/174 (63%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DF  +  +  F   I    KCDF+++  H E    +K+ EKK+    ++K  ++ + 
Sbjct: 256 FFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFE----QKREEKKSMPKEQKKAIKQKKD 311

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E   ++   ++DGR+E VGNFR+EP  LF GRG HP TG +KRR+ PE +T+N+G   P+
Sbjct: 312 EEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHPKTGSLKRRVYPEQITINIGEGVPV 371

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P+PGH W ++ H++ VTWLA W ++I    KYV+L+A S+ KG SD  K+E
Sbjct: 372 PE-PLPGHQWAEVKHDNTVTWLATWHENINNNVKYVFLAAGSSLKGQSDLKKYE 424

[23][TOP]
>UniRef100_B8CC91 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B8CC91_THAPS
          Length = 536

 Score =  160 bits (404), Expect = 6e-38
 Identities = 76/173 (43%), Positives = 111/173 (64%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DFR +L       +I   +KCDF  I+ HL ++K  +KA     T  ERK  ++++ 
Sbjct: 16  FFTDFRTILGKNH---IIKDFKKCDFGPIQRHLNEQKLIRKAI----TDEERKVNKDSKN 68

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E + +F  ALVDG  E VGN+ +EP   F GRG+HP  GK+K+R++PE V +N+  +AP+
Sbjct: 69  ETLFKFGYALVDGHLEKVGNYNMEPPGAFRGRGEHPKMGKLKQRVEPEQVMINVSEDAPV 128

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           P C VPGH WG++ H+  V WL  WK++I    KY+ L+A+S+FKG SD +K+
Sbjct: 129 PMCSVPGHAWGEVRHDPTVQWLCQWKENINNQVKYMQLAAQSSFKGKSDRSKY 181

[24][TOP]
>UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans
           RepID=Q5KB99_CRYNE
          Length = 881

 Score =  160 bits (404), Expect = 6e-38
 Identities = 87/177 (49%), Positives = 114/177 (64%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF DF+A++     K    +  LEKCDF  +  + E EK KKKA      T E K+A +A
Sbjct: 320 FFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKA-----LTKEEKKAIKA 374

Query: 176 EAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
           E +++   +  A VDGR+E VGNFR EP  LF GRG+HP  G VK R++PED+ +N+G  
Sbjct: 375 EKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIIINIGKE 434

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIP   +PG  W  I H++ VTWLA WK+++ G  KYV+LSA SA+KG SD AKFE
Sbjct: 435 APIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNGNAKYVFLSAGSAWKGQSDRAKFE 490

[25][TOP]
>UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans
           RepID=O59891_CRYNE
          Length = 844

 Score =  160 bits (404), Expect = 6e-38
 Identities = 87/177 (49%), Positives = 114/177 (64%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF DF+A++     K    +  LEKCDF  +  + E EK KKKA      T E K+A +A
Sbjct: 283 FFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKA-----LTKEEKKAIKA 337

Query: 176 EAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
           E +++   +  A VDGR+E VGNFR EP  LF GRG+HP  G VK R++PED+ +N+G  
Sbjct: 338 EKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIIINIGKE 397

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIP   +PG  W  I H++ VTWLA WK+++ G  KYV+LSA SA+KG SD AKFE
Sbjct: 398 APIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNGNAKYVFLSAGSAWKGQSDRAKFE 453

[26][TOP]
>UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR
          Length = 877

 Score =  159 bits (402), Expect = 1e-37
 Identities = 81/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F+ D+R LL       VI  L+ CDF+ I    + EK KKK      +T E+K  +E + 
Sbjct: 394 FWNDWRKLLGKNH---VIQKLDDCDFNPIYEWHQQEKEKKKQ----MSTEEKKVLKEEKL 446

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+V+G +E VGNFRVEP  LF GRG+HP  GK+K RI+P D+T+N+G +API
Sbjct: 447 KQEEKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKSRIRPSDITINIGKDAPI 506

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 507 PECPIPGERWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 561

[27][TOP]
>UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT
          Length = 926

 Score =  159 bits (401), Expect = 1e-37
 Identities = 80/175 (45%), Positives = 111/175 (63%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D++ +L        I +LE CDF  I    + EK KKK      TT E+K  +E   
Sbjct: 442 FFSDWKKILGKNH---TIQNLEDCDFGPIYEWHQQEKEKKKQ----MTTEEKKALKEERL 494

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +   ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+K+RI+P D+T+N+G +API
Sbjct: 495 QLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRIRPRDITINIGKDAPI 554

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ +++ VTWLA W D +     KYV+L+A S  KG SD  K+E
Sbjct: 555 PECPIPGERWKEVRNDNTVTWLAYWNDPVNLKECKYVFLAASSTLKGQSDKEKYE 609

[28][TOP]
>UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI000198447D
          Length = 883

 Score =  158 bits (400), Expect = 2e-37
 Identities = 82/175 (46%), Positives = 110/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R  L       VI   E CDF+ I    E EK KKK      TT E+K  +E + 
Sbjct: 400 FMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKEKKKQ----MTTEEKKALKEEKL 452

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+K+RI P D+T+N+G  AP+
Sbjct: 453 KQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRICPSDITINIGKEAPV 512

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 513 PECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 567

[29][TOP]
>UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B5Y3I3_PHATR
          Length = 594

 Score =  158 bits (400), Expect = 2e-37
 Identities = 79/173 (45%), Positives = 106/173 (61%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FFADFR +L      K     +KCDF  I  HL ++K  +KA     T  ERK  +E  +
Sbjct: 82  FFADFREILGKKHIVK---EFKKCDFEPIRKHLNEQKIIRKAI----TDEERKANKEDRS 134

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + + QF  ++VDG  E VGNF +EP   F GRG+HP  GK+K R+ PE V+LNL   AP+
Sbjct: 135 QTLHQFGFSIVDGHIERVGNFNMEPPGAFRGRGEHPKMGKLKSRVLPEQVSLNLSECAPV 194

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           P CPVPGH W  + H+    WLA WK++I    KY+ L+A+S+FKG SD +K+
Sbjct: 195 PPCPVPGHAWSDVRHDPRGQWLATWKENINNQSKYMQLAAQSSFKGKSDRSKY 247

[30][TOP]
>UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT
          Length = 926

 Score =  158 bits (400), Expect = 2e-37
 Identities = 79/175 (45%), Positives = 112/175 (64%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D++ +L        + +LE CDF  I    + EK K+K      TT E+K  +E   
Sbjct: 442 FFSDWKKMLGKNH---TVQNLEDCDFGPIYEWHQQEKEKRKQ----MTTEEKKALKEERL 494

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+K+RI+P D+T+N+G +API
Sbjct: 495 QQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPRDITINIGKDAPI 554

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ +++ VTWLA W D I     KYV+L+A S  KG SD  K+E
Sbjct: 555 PECPIPGERWKEVRNDNTVTWLAFWNDPINQKECKYVFLAASSTLKGQSDKEKYE 609

[31][TOP]
>UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7PX10_VITVI
          Length = 789

 Score =  158 bits (400), Expect = 2e-37
 Identities = 82/175 (46%), Positives = 110/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R  L       VI   E CDF+ I    E EK KKK      TT E+K  +E + 
Sbjct: 306 FMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKEKKKQ----MTTEEKKALKEEKL 358

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+VDG +E VGNFRVEP  LF GRG+HP  GK+K+RI P D+T+N+G  AP+
Sbjct: 359 KQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRICPSDITINIGKEAPV 418

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 419 PECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE 473

[32][TOP]
>UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum
           RepID=Q0UUB0_PHANO
          Length = 887

 Score =  158 bits (400), Expect = 2e-37
 Identities = 84/181 (46%), Positives = 109/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A+L  T   K        I   EKCDF  I  H E ++A KKA   A+  A + 
Sbjct: 319 FFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDFKPIFEHFEADRAAKKALPAAEKKALKA 378

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E   AEAE    +   + DGR++ VGNFRVEP  LF GRG+HP TG++K+R+ PE +T+N
Sbjct: 379 EKDAAEAE----YMFCMWDGRKQKVGNFRVEPPGLFRGRGEHPKTGRIKKRVAPEQITIN 434

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G NA +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KF
Sbjct: 435 IGENAKVPP-PPAGHRWKEVKHDHEGTWLAMWQENINGAYKYVMLAANSDIKGQSDFKKF 493

Query: 521 E 523
           E
Sbjct: 494 E 494

[33][TOP]
>UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE
          Length = 2575

 Score =  158 bits (399), Expect = 2e-37
 Identities = 77/174 (44%), Positives = 114/174 (65%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            F  D+RA +   +  K +T ++KCDFS I +H +     +KA  K     E+++ +EAEA
Sbjct: 1930 FMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQRAEARKAASKE----EKEKRKEAEA 1984

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
            +   ++  AL+DGR+ T+GNFR+EP  LF GRG+HP  GK+K R+ PEDV +N+GP   +
Sbjct: 1985 KLKEEYGFALMDGRKVTIGNFRIEPPGLFQGRGEHPKMGKLKLRVMPEDVIINVGPKDKV 2044

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            PE P  GH W ++ H++ VTWLAGWK++I    KY+ LSA++  KG +D  K+E
Sbjct: 2045 PE-PPAGHKWKEVKHDNTVTWLAGWKENIQDQNKYIMLSADTHIKGRNDWKKYE 2097

[34][TOP]
>UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8IDM1_CHLRE
          Length = 586

 Score =  157 bits (398), Expect = 3e-37
 Identities = 82/176 (46%), Positives = 112/176 (63%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           F+  F+ +L       VI  L+KCDF+ I + H+   +AKK   K+     E+   ++ +
Sbjct: 90  FWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQREAKKGISKE-----EKDRIKKEK 141

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            E+  ++ VA VDGR E VGNFRVEP  LF GRG+HP  GK+K+R+ P D+T+N+G N P
Sbjct: 142 DEKEAKYKVAYVDGRPEPVGNFRVEPPGLFRGRGEHPKMGKIKKRVYPRDITINIGENEP 201

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523
           +PE P PG  W ++ H+  VTWLA WKD+I T  YKYV+L A S FK  SD AK+E
Sbjct: 202 VPEHPYPGQTWKEVKHDHTVTWLAYWKDTISTKDYKYVFLGATSTFKADSDLAKYE 257

[35][TOP]
>UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FVE9_CANGA
          Length = 717

 Score =  157 bits (398), Expect = 3e-37
 Identities = 84/177 (47%), Positives = 112/177 (63%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF+ +L D   T+    I S ++ DFS     + D   + K EKK+ T  ++KE R 
Sbjct: 154 FFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHDYFVQLKEEKKSMTAMQKKEIRL 209

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
              +   ++    +DGR E VGNF+VEP +LF GRG HP TGK+KRRI+PED+ LNLG  
Sbjct: 210 EREKFEEKYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRIRPEDIVLNLGEG 269

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIP  P  GH WG+I H++ V WLA W+++I G +KYV L+A S+ KG SD  KFE
Sbjct: 270 APIPP-PPSGHQWGEIRHDNTVQWLAMWRENIFGSFKYVRLAANSSLKGQSDFKKFE 325

[36][TOP]
>UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FTA8_NANOT
          Length = 896

 Score =  157 bits (398), Expect = 3e-37
 Identities = 82/181 (45%), Positives = 111/181 (61%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+A++  T  AK        +    KCDF  I  H E    K +A+KKA T AE+K
Sbjct: 328 FFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVPIFEHHE----KLRAQKKAMTAAEKK 383

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
            A+  +      +   + DGR++ VGNFRVEP  LF GRG+HP TG VK R+QPE +T+N
Sbjct: 384 AAKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGTVKTRVQPEQITIN 443

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +AP+P  P  GH W ++ H+   TWLA W++++ G YKYV L+A S  KG SD+ KF
Sbjct: 444 IGKDAPVP-APPEGHRWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDVKGQSDYKKF 502

Query: 521 E 523
           E
Sbjct: 503 E 503

[37][TOP]
>UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FNH4_CANGA
          Length = 744

 Score =  157 bits (397), Expect = 4e-37
 Identities = 83/177 (46%), Positives = 114/177 (64%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF  +L +   T+    IT  +KCDFS++  + E     KK EK+  +  E+K+ + 
Sbjct: 181 FFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFE----LKKEEKRNMSREEKKQIKL 236

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
            + +   +F    +DGR+E VGNFRVEP +LF GRG HP TGK+KRR+ PED+ LNL  +
Sbjct: 237 EKDKFEEKFKFCELDGRKEQVGNFRVEPPDLFRGRGAHPKTGKLKRRVYPEDIILNLSKD 296

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIP  P  GH+WG+I H++ V WLA WK++I G +KYV L+A S+  G SD  KFE
Sbjct: 297 APIPPAP-QGHHWGEIRHDNTVQWLAMWKENIFGSFKYVRLAANSSLNGQSDLKKFE 352

[38][TOP]
>UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC
          Length = 894

 Score =  157 bits (396), Expect = 5e-37
 Identities = 81/175 (46%), Positives = 114/175 (65%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R +L       VI +LE CDF+ I    + EK KKK      T  E+K  +E   
Sbjct: 411 FMDDWRKILGKNH---VIQNLEDCDFTPIYEWHQREKEKKKK----MTAEEKKVLKEERL 463

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++  A+V+G +E VGNFRVEP +LF GRG+HP  GK+K+ I+P D+T+N+G +API
Sbjct: 464 KQEEKYMWAIVNGVKEKVGNFRVEPPSLFRGRGEHPKMGKLKKCIRPSDITINIGKDAPI 523

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG +W +I H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 524 PECPIPGESWKEIRHDNTVTWLAFWNDPIKPREFKYVFLAASSSLKGQSDKEKYE 578

[39][TOP]
>UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea
           okayama7#130 RepID=A8N6Y9_COPC7
          Length = 863

 Score =  157 bits (396), Expect = 5e-37
 Identities = 79/176 (44%), Positives = 112/176 (63%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF DF+ +L     +    IT+ E CDF  +  + E EKAK+KA     T  E+K A++ 
Sbjct: 319 FFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAEKAKRKA----MTNEEKKAAKKK 374

Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
           + E   ++   ++DGR+E VGNFR+EP  LF GRG+HP  G +K+R+ PED+T+N+G  A
Sbjct: 375 KDELEEKYKTCVMDGRKEKVGNFRIEPPGLFRGRGEHPKKGSLKKRVYPEDITINIGKEA 434

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            IP   +PG  W K+IH++ VTWLA W ++I   +KYV+L+A S  KG SD  KFE
Sbjct: 435 KIPVPNIPG-KWKKVIHDNTVTWLATWTENINNSHKYVFLAAGSRLKGQSDMQKFE 489

[40][TOP]
>UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis
           thaliana RepID=Q8RX06_ARATH
          Length = 514

 Score =  156 bits (395), Expect = 7e-37
 Identities = 82/176 (46%), Positives = 115/176 (65%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           F+ D+R LL       VI  L+ CDF+ I E HLE+     K +KK  +T E+K  +E +
Sbjct: 28  FWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKALKEEK 79

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E +GNFRVEP  LF GRG+HP  GK+K+RI P ++TLN+G  AP
Sbjct: 80  MKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPKMGKLKKRIHPCEITLNIGKGAP 139

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           IPECP+ G  W ++ H++ VTWLA W D I    +KYV+L A S+ KG+SD  K+E
Sbjct: 140 IPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYE 195

[41][TOP]
>UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59XR0_CANAL
          Length = 780

 Score =  156 bits (395), Expect = 7e-37
 Identities = 84/175 (48%), Positives = 110/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+K  +E +
Sbjct: 220 FFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEK 275

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    +    ++GR+E VGNFR+EP  LF GRG HP TGK+KRR+ PE VTLNLG +A 
Sbjct: 276 EKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGKDAK 335

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE
Sbjct: 336 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 389

[42][TOP]
>UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59WV6_CANAL
          Length = 780

 Score =  156 bits (395), Expect = 7e-37
 Identities = 84/175 (48%), Positives = 110/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+K  +E +
Sbjct: 220 FFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEK 275

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    +    ++GR+E VGNFR+EP  LF GRG HP TGK+KRR+ PE VTLNLG +A 
Sbjct: 276 EKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGKDAK 335

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE
Sbjct: 336 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 389

[43][TOP]
>UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH
          Length = 916

 Score =  156 bits (395), Expect = 7e-37
 Identities = 82/176 (46%), Positives = 115/176 (65%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           F+ D+R LL       VI  L+ CDF+ I E HLE+     K +KK  +T E+K  +E +
Sbjct: 430 FWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKALKEEK 481

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A+VDG +E +GNFRVEP  LF GRG+HP  GK+K+RI P ++TLN+G  AP
Sbjct: 482 MKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPKMGKLKKRIHPCEITLNIGKGAP 541

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           IPECP+ G  W ++ H++ VTWLA W D I    +KYV+L A S+ KG+SD  K+E
Sbjct: 542 IPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYE 597

[44][TOP]
>UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36
           RepID=B9WIH6_CANDC
          Length = 777

 Score =  155 bits (393), Expect = 1e-36
 Identities = 84/175 (48%), Positives = 109/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+K  +E +
Sbjct: 217 FFNDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE----KLREEKKAMSKEEKKRIKEEK 272

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    F    ++GR+E VGNFR+EP  LF GRG HP TGK+KRR+ PE VTLNL  +A 
Sbjct: 273 EKEEEPFKTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVAPEQVTLNLSKDAK 332

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE
Sbjct: 333 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 386

[45][TOP]
>UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora
           DSM 70294 RepID=A7TJW1_VANPO
          Length = 799

 Score =  155 bits (392), Expect = 2e-36
 Identities = 81/177 (45%), Positives = 111/177 (62%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEK---CDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF+ +L +         LEK   CDFS++  + E ++     ++K  +  E+K+ R 
Sbjct: 236 FFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEIQRE----QRKKLSPQEKKQLRL 291

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
            + E+   F    +DGR E VGNFRVEP +LF GRG HP TGK+KRR+ PED+ LNL  N
Sbjct: 292 EKEEQEEPFKFCELDGRREQVGNFRVEPPDLFRGRGAHPKTGKLKRRVYPEDIVLNLDRN 351

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIP  P  GH WG+I H++ V WLA W+++I+  +KYV L+A S+ KG SD  KFE
Sbjct: 352 APIPAVP-EGHKWGEIKHDNTVQWLAMWRENISNSFKYVRLAANSSLKGQSDFKKFE 407

[46][TOP]
>UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JVV4_UNCRE
          Length = 889

 Score =  155 bits (391), Expect = 2e-36
 Identities = 82/181 (45%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A++  T  AK        I   +KCDF  I  + E     K+ EKKA   AERK
Sbjct: 339 FFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIFEYYE----MKRLEKKALPAAERK 394

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   + DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 395 RLKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKTRVQPEQITIN 454

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 455 IGKGAAVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 513

Query: 521 E 523
           E
Sbjct: 514 E 514

[47][TOP]
>UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224
           RepID=B6QNQ2_PENMQ
          Length = 860

 Score =  154 bits (390), Expect = 3e-36
 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+A+L  T  AK        I   +KCDF  I  + E ++ +KK    A+  A + 
Sbjct: 292 FFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIFEYYEGKRLEKKNLSAAEKKALKA 351

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E  EAEA     +   + DGR++ VGNFRVEP +LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 352 ERDEAEAP----YMYCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKTRVMPEQITIN 407

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +A +P  P  GH W ++ H+   TWLA W++++ G YKYV L+A S  KG SD+ KF
Sbjct: 408 IGKDAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGQSDYKKF 466

Query: 521 E 523
           E
Sbjct: 467 E 467

[48][TOP]
>UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus
           NAm1 RepID=A6R590_AJECN
          Length = 651

 Score =  154 bits (390), Expect = 3e-36
 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A + ++  AK        + S EKCDF  I  + E      + EKK+  +AE+K
Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIFEYYE----AARLEKKSLPSAEKK 396

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 397 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 456

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P PGH W +I H+   TWLA W++++ G YKYV L+A S  KG+SD+ KF
Sbjct: 457 IGKEAKVP-VPPPGHKWKEIKHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGLSDYKKF 515

Query: 521 E 523
           E
Sbjct: 516 E 516

[49][TOP]
>UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA
           n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC
          Length = 884

 Score =  154 bits (390), Expect = 3e-36
 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DFR +L  T  AK        I    KCDF  I A+ ++++     EKKA   AE+K
Sbjct: 316 FFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQPIFAYYDNQRQ----EKKALPPAEKK 371

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +  +   +   + DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 372 RLKAEKDAQEAPYMFCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKSRVQPEQITIN 431

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 432 IGKDAPVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 490

Query: 521 E 523
           E
Sbjct: 491 E 491

[50][TOP]
>UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH
          Length = 917

 Score =  154 bits (389), Expect = 4e-36
 Identities = 81/176 (46%), Positives = 111/176 (63%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE-AREAE 178
           F+ D+R LL      K   SL+ CDF+ I      EK  KK     Q TAE K   +E +
Sbjct: 428 FWNDWRKLLGKNHMIK---SLDDCDFTPIYEWYMQEKETKK-----QMTAEEKRIVKEEK 479

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            ++  ++  A++DG  E +GNFRVEP  LF GRG+HP  GK+K+RI+P D+T+N+G  AP
Sbjct: 480 LKQEEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKEAP 539

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           IPECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 540 IPECPIPGERWKEVKHDNTVTWLAFWSDPINPKEFKYVFLAASSSLKGQSDKEKYE 595

[51][TOP]
>UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T3W2_PHYPA
          Length = 632

 Score =  154 bits (389), Expect = 4e-36
 Identities = 77/159 (48%), Positives = 104/159 (65%), Gaps = 1/159 (0%)
 Frame = +2

Query: 50  VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREE 229
           VI   E CDF+ I     D  A++K  KK+ +T E+K  +E +     ++  A+VDG +E
Sbjct: 163 VIKKFELCDFTPIF----DWHAREKERKKSMSTEEKKRLKEEKLAVEEKYMWAVVDGVKE 218

Query: 230 TVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHN 409
            VGNFRVEP  LF GRGDHP  GK+K RI P D+ +N+G +A +PECP+PG  W +I H+
Sbjct: 219 KVGNFRVEPPGLFRGRGDHPKMGKLKTRILPHDIVINIGKDAAVPECPIPGQRWKEIRHD 278

Query: 410 SCVTWLAGWKDSITG-GYKYVWLSAESAFKGMSDHAKFE 523
           + VTWLA WKD I    +KYV+L+A S+ KG SD  K+E
Sbjct: 279 NTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMQKYE 317

[52][TOP]
>UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA
          Length = 763

 Score =  154 bits (389), Expect = 4e-36
 Identities = 76/174 (43%), Positives = 108/174 (62%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DF+     T    +    E CDF+ +  + E    KKK EKK ++  E+K+ +E + 
Sbjct: 204 FFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFE----KKKEEKKNKSKEEKKKIKEEKD 259

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
               ++    +DGR+E VGNFR+EP  LF GRGDHP TGK+K R+ PE V +N+G ++ I
Sbjct: 260 ALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDHPKTGKLKTRVVPEQVIINIGKDSVI 319

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGHNW ++ H++ VTWLA W +++    KYV+LSA S+ KG SD  K+E
Sbjct: 320 PS-PPPGHNWKEVRHDNTVTWLATWNENVNNNVKYVFLSAGSSLKGQSDLKKYE 372

[53][TOP]
>UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500
           RepID=B8MH68_TALSN
          Length = 864

 Score =  154 bits (389), Expect = 4e-36
 Identities = 80/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+A+L  T  AK        I    KCDF  I  + +     K+ EKKA + AE+K
Sbjct: 296 FFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKPIFEYYD----AKRLEKKAMSAAEKK 351

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+QPE +T+N
Sbjct: 352 ALKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPGLFRGRGEHPKTGKVKTRVQPEQITIN 411

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W++++ G YKYV L+A S  KG SD+ KF
Sbjct: 412 IGKEAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGQSDYKKF 470

Query: 521 E 523
           E
Sbjct: 471 E 471

[54][TOP]
>UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri
           RepID=Q00XV7_OSTTA
          Length = 783

 Score =  154 bits (388), Expect = 5e-36
 Identities = 79/175 (45%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F   F+  LA+   A  IT   KCDF+++  H     AK + EKK  T+ E+K  +  + 
Sbjct: 296 FMDGFKEALANGPHA-FITDFRKCDFTKMYNHF----AKIREEKKQMTSEEKKRIKAEKD 350

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +    +T A +DGR E VGNFR+EP  LF GRG+HP  GK+KRR+ PED+T+N+G +A +
Sbjct: 351 KAEEMYTWATIDGRREKVGNFRIEPPGLFRGRGEHPKMGKIKRRVMPEDITINIGKDARV 410

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH+W  +IHN   TWLAGW D I    +KYV   A S  K  SD  K+E
Sbjct: 411 PP-PPPGHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYE 464

[55][TOP]
>UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143
           RepID=C6HAF8_AJECH
          Length = 909

 Score =  154 bits (388), Expect = 5e-36
 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A + ++  AK        I S +KCDF  I  + E      + EKK+  +AE+K
Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYE----AARLEKKSLPSAEKK 396

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 397 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 456

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KF
Sbjct: 457 IGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGLSDYKKF 515

Query: 521 E 523
           E
Sbjct: 516 E 516

[56][TOP]
>UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR
           RepID=C0NC53_AJECG
          Length = 909

 Score =  154 bits (388), Expect = 5e-36
 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A + ++  AK        I S +KCDF  I  + E      + EKK+  +AE+K
Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYE----AARLEKKSLPSAEKK 396

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 397 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 456

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KF
Sbjct: 457 IGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGLSDYKKF 515

Query: 521 E 523
           E
Sbjct: 516 E 516

[57][TOP]
>UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1
           RepID=UPI000023DEFB
          Length = 910

 Score =  153 bits (387), Expect = 6e-36
 Identities = 84/184 (45%), Positives = 112/184 (60%), Gaps = 10/184 (5%)
 Frame = +2

Query: 2   FFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKAQTTA 151
           FF DF+       + D +  KV I SL+KC+F +I  +    +E  K K   +++ +   
Sbjct: 334 FFDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEKEAAK 393

Query: 152 ERKEAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDV 331
            +K+A EA       FT    DGR+E VGNFRVEP +LF GRG+HP TGKVK+R+QPE +
Sbjct: 394 AKKDALEAP------FTHCTWDGRKEKVGNFRVEPPSLFRGRGEHPKTGKVKQRVQPEQI 447

Query: 332 TLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDH 511
           T+N+G  A IPE P  GH W  + H+   TWLA W+++I   YKYV L A+SA KG SD 
Sbjct: 448 TINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMWQENINQNYKYVMLGADSAIKGQSDF 506

Query: 512 AKFE 523
            KFE
Sbjct: 507 KKFE 510

[58][TOP]
>UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU
          Length = 909

 Score =  153 bits (387), Expect = 6e-36
 Identities = 84/184 (45%), Positives = 112/184 (60%), Gaps = 10/184 (5%)
 Frame = +2

Query: 2   FFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKAQTTA 151
           FF DF+       + D +  KV I SL+KC+F +I  +    +E  K K   +++ +   
Sbjct: 333 FFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEKEAAK 392

Query: 152 ERKEAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDV 331
            +K+A EA       FT    DGR+E VGNFRVEP +LF GRG+HP TGKVK+R+QPE +
Sbjct: 393 AKKDALEAP------FTHCTWDGRKEKVGNFRVEPPSLFRGRGEHPKTGKVKQRVQPEQI 446

Query: 332 TLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDH 511
           T+N+G  A IPE P  GH W  + H+   TWLA W+++I   YKYV L A+SA KG SD 
Sbjct: 447 TINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMWQENINQNYKYVMLGADSAIKGQSDF 505

Query: 512 AKFE 523
            KFE
Sbjct: 506 KKFE 509

[59][TOP]
>UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL
          Length = 778

 Score =  153 bits (387), Expect = 6e-36
 Identities = 83/175 (47%), Positives = 109/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+K  +E +
Sbjct: 218 FFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEK 273

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    +    ++GR+E VGNFR+EP  LF GRG HP TGK+KRR+  E VTLNLG +A 
Sbjct: 274 EKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVSEQVTLNLGKDAK 333

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE
Sbjct: 334 IPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFE 387

[60][TOP]
>UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA
          Length = 909

 Score =  152 bits (385), Expect = 1e-35
 Identities = 77/160 (48%), Positives = 109/160 (68%), Gaps = 2/160 (1%)
 Frame = +2

Query: 50  VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGRE 226
           +I +L+ CDF+ I      E  + K EKK Q +AE K+A +E + ++  ++  A+VDG +
Sbjct: 423 IIKNLDDCDFTPIY-----EWFRLKKEKKKQMSAEEKKAVKEEKLKQEEKYMWAVVDGVK 477

Query: 227 ETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIH 406
           E VGNFRVEP  LF GR   P  GK+K+RI P D+T+N+G +APIPECP+PG +W ++ H
Sbjct: 478 ENVGNFRVEPPGLFRGRESIPKMGKLKKRISPSDITINIGKDAPIPECPIPGESWKEVRH 537

Query: 407 NSCVTWLAGWKDSITG-GYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA W D I G  +KYV+L+A S+ KG SD  K+E
Sbjct: 538 DNTVTWLAYWNDPINGKEFKYVFLAASSSLKGQSDKEKYE 577

[61][TOP]
>UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA
          Length = 892

 Score =  152 bits (385), Expect = 1e-35
 Identities = 78/175 (44%), Positives = 110/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F+ D+R LL       VI +L+ CDF+ I    + EK KKK      TT E+K  +E + 
Sbjct: 404 FWNDWRKLLGRNH---VIQNLKDCDFTPIYDWCQSEKEKKKQ----MTTEEKKALKEEKL 456

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           ++  ++T A+VDG +  VGNFRVEP  LF GRG+HP  G++K+RI P D+ +N+G  A +
Sbjct: 457 KQEEKYTWAIVDGVKRRVGNFRVEPPGLFRGRGEHPKMGRLKKRIHPSDIVINIGSEAQV 516

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAESAFKGMSDHAKFE 523
           PECP+PG  W  I +++ VTWL  W D I    +KYV+L+A S+ KG SD  K+E
Sbjct: 517 PECPIPGEGWKDIRNDNTVTWLCYWSDPINPKLFKYVFLAASSSLKGQSDKEKYE 571

[62][TOP]
>UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545
           RepID=C1MGX0_9CHLO
          Length = 685

 Score =  152 bits (385), Expect = 1e-35
 Identities = 77/176 (43%), Positives = 110/176 (62%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 178
           F+  F+ +L     A  I   +KCDF+++   HL     K++ +KKA +  ++K+A+ A+
Sbjct: 223 FWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHL-----KEREKKKAISNEDKKKAKAAK 277

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
                ++  A++DGR E VGNFRVEP  LF GRG+HP  G++K+RI PED+T+N+G   P
Sbjct: 278 DAEEEKYNWAVIDGRRERVGNFRVEPPGLFRGRGEHPKMGRIKKRIMPEDITINIGKGVP 337

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PGH W  +IHN  VTWL GW D+I T  +KYV   A S+ K  SD  K+E
Sbjct: 338 APD-PGPGHKWKDVIHNDTVTWLCGWNDTINTKDWKYVQFGAMSSIKAESDIQKYE 392

[63][TOP]
>UniRef100_A9T368 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T368_PHYPA
          Length = 502

 Score =  152 bits (385), Expect = 1e-35
 Identities = 76/160 (47%), Positives = 104/160 (65%), Gaps = 2/160 (1%)
 Frame = +2

Query: 50  VITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGRE 226
           VI   E CDF+ I + H     A++K  KK  +  E+K  +E +     ++  A+VDG +
Sbjct: 33  VIKKFELCDFTPIFQWH-----AREKERKKNMSAEEKKRLKEEKLAAEEKYMWAVVDGVK 87

Query: 227 ETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIH 406
           E VGNFRVEP  LF GRGDHP  GK+K RI P D+ +N+G +AP+PECP+PG  W ++ H
Sbjct: 88  EKVGNFRVEPPGLFRGRGDHPKMGKLKTRILPHDIVINIGKDAPVPECPIPGQKWKEVRH 147

Query: 407 NSCVTWLAGWKDSITG-GYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA WKD I    +KYV+L+A S+ KG SD  K+E
Sbjct: 148 DNTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMLKYE 187

[64][TOP]
>UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR
          Length = 881

 Score =  152 bits (385), Expect = 1e-35
 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+ +L       D+K  KV I    KCDF  I A+ +     K+ EKK    AE+K
Sbjct: 313 FFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLPPAEKK 368

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 369 RLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKSRVQPEQITIN 428

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 429 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 487

Query: 521 E 523
           E
Sbjct: 488 E 488

[65][TOP]
>UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357
           RepID=B8MY66_ASPFN
          Length = 881

 Score =  152 bits (385), Expect = 1e-35
 Identities = 81/181 (44%), Positives = 111/181 (61%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+ +L       D+K  KV I    KCDF  I A+ +     K+ EKK    AE+K
Sbjct: 313 FFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLPPAEKK 368

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 369 RLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKSRVQPEQITIN 428

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 429 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 487

Query: 521 E 523
           E
Sbjct: 488 E 488

[66][TOP]
>UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium
           parvum Iowa II RepID=Q5CY81_CRYPV
          Length = 653

 Score =  152 bits (384), Expect = 1e-35
 Identities = 77/155 (49%), Positives = 104/155 (67%), Gaps = 2/155 (1%)
 Frame = +2

Query: 65  EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244
           EKC+F  I+ + EDEK  KK   K +   ++K   + E+     F  ALVD  +E VGNF
Sbjct: 137 EKCNFDIIKQYFEDEKEAKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNF 192

Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCV 418
           R+EP  LF GRG+HP +G +KRRI PEDVTLN+  +AP+P+ P  + GH W  I H++ V
Sbjct: 193 RIEPPGLFKGRGEHPKSGMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTV 252

Query: 419 TWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           TWLA ++DSI   +KY++LSA S FKGMSD+ K+E
Sbjct: 253 TWLAYYRDSINNQFKYIFLSASSGFKGMSDYNKYE 287

[67][TOP]
>UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis
           RepID=Q5CN58_CRYHO
          Length = 641

 Score =  152 bits (384), Expect = 1e-35
 Identities = 77/155 (49%), Positives = 104/155 (67%), Gaps = 2/155 (1%)
 Frame = +2

Query: 65  EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244
           EKC+F  I+ + EDEK  KK   K +   ++K   + E+     F  ALVD  +E VGNF
Sbjct: 125 EKCNFDIIKQYFEDEKEAKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNF 180

Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCV 418
           R+EP  LF GRG+HP +G +KRRI PEDVTLN+  +AP+P+ P  + GH W  I H++ V
Sbjct: 181 RIEPPGLFKGRGEHPKSGMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTV 240

Query: 419 TWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           TWLA ++DSI   +KY++LSA S FKGMSD+ K+E
Sbjct: 241 TWLAYYRDSINNQFKYIFLSASSGFKGMSDYNKYE 275

[68][TOP]
>UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HDT9_CHAGB
          Length = 907

 Score =  151 bits (382), Expect = 2e-35
 Identities = 81/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FFADF+ +L  T  AK        I   +K DF++I  H +     +KA   A+  AE+ 
Sbjct: 335 FFADFKDILKKTGGAKDKQGKPVDIKEFKKLDFTKIFDHYKALGDARKARPAAEKKAEKA 394

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E  +AE      F     DGR+E VGNFRVEP  LF GRG+HP TG VK+R+ PE VT+N
Sbjct: 395 EKDKAEGH----FMFCKWDGRKEKVGNFRVEPPGLFRGRGEHPKTGTVKKRVMPEQVTIN 450

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +A +P  P PGH W  + H++  TWLA W++++ G YKYV L+A S  KG +D  KF
Sbjct: 451 IGKDAKVP-APPPGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSTVKGQADFKKF 509

Query: 521 E 523
           E
Sbjct: 510 E 510

[69][TOP]
>UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735
           delta SOWgp RepID=C5P0Y8_COCP7
          Length = 905

 Score =  151 bits (382), Expect = 2e-35
 Identities = 81/181 (44%), Positives = 107/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A++  T  AK       +I   +KCDF  I  + E     K+ EKKA   AERK
Sbjct: 337 FFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE----MKREEKKALPAAERK 392

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   + DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 393 RLKVEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKTRVQPEQITIN 452

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KF
Sbjct: 453 IGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDFKKF 511

Query: 521 E 523
           E
Sbjct: 512 E 512

[70][TOP]
>UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis
           RepID=Q1DXZ1_COCIM
          Length = 905

 Score =  151 bits (381), Expect = 3e-35
 Identities = 81/181 (44%), Positives = 107/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A++  T  AK       +I   +KCDF  I  + E     K+ EKKA   AERK
Sbjct: 337 FFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE----MKREEKKALPAAERK 392

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   + DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 393 RLKAEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKIRVQPEQITIN 452

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KF
Sbjct: 453 IGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDFKKF 511

Query: 521 E 523
           E
Sbjct: 512 E 512

[71][TOP]
>UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DEP3_LACTC
          Length = 756

 Score =  151 bits (381), Expect = 3e-35
 Identities = 81/178 (45%), Positives = 111/178 (62%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF  +L +    K    I   E CDFS++  + + +K +KK     Q +++ K+  +
Sbjct: 193 FFNDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQLQKEQKK-----QLSSQEKKKLK 247

Query: 173 AEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
            E E+  + F    +DGR+E VGNFR+EP  LF GRG HP TGK+KRR+ PEDV LNL  
Sbjct: 248 IEKEQFEEPFKFCFLDGRKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVYPEDVVLNLDK 307

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            A IP+ P  GH WG+I H+S V WLA W+++I+  +KYV  +A S+ KGMSD  KFE
Sbjct: 308 EAEIPKAP-EGHKWGEIRHDSTVQWLAMWRENISNSFKYVRFAANSSLKGMSDFKKFE 364

[72][TOP]
>UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1D4R5_NEOFI
          Length = 886

 Score =  151 bits (381), Expect = 3e-35
 Identities = 81/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+ +L  T  AK        I    KCDF  I  + E     K+ EKK    AE+K
Sbjct: 318 FFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYE----AKRIEKKNLPPAEKK 373

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   L DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 374 RLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQPEQITIN 433

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KF
Sbjct: 434 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGLSDYKKF 492

Query: 521 E 523
           E
Sbjct: 493 E 493

[73][TOP]
>UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL
          Length = 886

 Score =  151 bits (381), Expect = 3e-35
 Identities = 80/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF+DF+ +L  T  AK        I    KCDF  I A+ +     K+ EK+    AE+K
Sbjct: 318 FFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQSIFAYYD----AKRIEKRNIPPAEKK 373

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   L DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 374 RLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 433

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KF
Sbjct: 434 IGKGAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDFKKF 492

Query: 521 E 523
           E
Sbjct: 493 E 493

[74][TOP]
>UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404
           RepID=C5M985_CANTT
          Length = 777

 Score =  150 bits (379), Expect = 5e-35
 Identities = 81/175 (46%), Positives = 109/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L +     V I   EK DFS++ A+ E ++     EKKA +  E+K  +E  
Sbjct: 217 FFNDFLEVLKECGGCGVEIKEFEKMDFSKMYAYYEQQRE----EKKALSRDEKKRLKEER 272

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    +    ++GR+E VGNFR+EP  LF GRG HP TGK+KRR+ PE VTLNLG +A 
Sbjct: 273 DKFEEPYKTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVAPEQVTLNLGKDAK 332

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +PE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE
Sbjct: 333 VPE-PPAGHQWGEIRHDNEVTWLAMWKENISDSTKYVRFANNSSIKGQSDFKKFE 386

[75][TOP]
>UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7EXF7_SCLS1
          Length = 911

 Score =  150 bits (379), Expect = 5e-35
 Identities = 80/181 (44%), Positives = 107/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF   +  T  AK        I    K DF  I  + +     K  E+KA++ AE+K
Sbjct: 339 FFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIFEYYDG----KSTERKARSAAEKK 394

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             + A+ E    +   + DGR+E VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 395 AEKAAKDEAEAPYKTCIWDGRKEDVGNFRVEPPGLFRGRGEHPKTGKVKLRVTPEQITIN 454

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W  I H++  TWLA W+++I G YKYV L+A+S+ KG SD+ KF
Sbjct: 455 IGKEATVPS-PPEGHKWKAIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDYKKF 513

Query: 521 E 523
           E
Sbjct: 514 E 514

[76][TOP]
>UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66
           RepID=B6ABX7_9CRYT
          Length = 660

 Score =  150 bits (378), Expect = 7e-35
 Identities = 74/155 (47%), Positives = 105/155 (67%), Gaps = 2/155 (1%)
 Frame = +2

Query: 65  EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244
           +KCDFS I+ H ++EK +KK   K Q   +++   E+E+     +  ALVD  +E VGNF
Sbjct: 133 DKCDFSLIKEHFDEEKERKKNMNKEQKEQQKRIKNESESP----YIYALVDWIKEKVGNF 188

Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIP--ECPVPGHNWGKIIHNSCV 418
           R+EP  LF GRG+HP +G +K+RI  E+VTLN+  +AP+P  +  + GH W  + H+S V
Sbjct: 189 RIEPPGLFRGRGEHPKSGMLKKRIFSEEVTLNVAEDAPVPKVDSSIIGHAWKDVFHDSNV 248

Query: 419 TWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           TWLA +KDSI   +KY++LSA S FKGMSD+ K+E
Sbjct: 249 TWLAYYKDSINNQFKYIFLSASSGFKGMSDYNKYE 283

[77][TOP]
>UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9SIQ6_9PEZI
          Length = 891

 Score =  150 bits (378), Expect = 7e-35
 Identities = 75/177 (42%), Positives = 112/177 (63%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFA--KVITSLEKCDFSRIEAH-LEDEKAKKKAEKKAQTTAERKEARE 172
           FF DFR ++ +   A  K    ++  DF +I    + D   ++ A +K +T  E+K+ +E
Sbjct: 320 FFEDFREVIKEHGSATDKDGKKVDIKDFHKINWQPMADYAEQQSAMRKNRTKEEKKQIKE 379

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
            +  R   F   L DGR+E +GNFRVEP +LF GRGDHP TG++K+++ PE +T+N+G +
Sbjct: 380 EKDAREEPFKYCLWDGRKEKMGNFRVEPPSLFRGRGDHPKTGRIKKQVFPEQITINIGKD 439

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           A IP+ P  GH W  ++H++  TWLA W+++I G YKYV   + S+ KG SDH KFE
Sbjct: 440 AKIPK-PPDGHKWKAVVHDNKATWLASWQENINGAYKYVMTGSSSSVKGKSDHMKFE 495

[78][TOP]
>UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2
           Tax=Emericella nidulans RepID=C8VUK1_EMENI
          Length = 871

 Score =  150 bits (378), Expect = 7e-35
 Identities = 79/181 (43%), Positives = 109/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FFADF+ +L  T  AK        I    KCDF  I  + + ++     EKKA   AE+K
Sbjct: 303 FFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQRQ----EKKALPPAEKK 358

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +  +   +   + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 359 RLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 418

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 419 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 477

Query: 521 E 523
           E
Sbjct: 478 E 478

[79][TOP]
>UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC
          Length = 998

 Score =  150 bits (378), Expect = 7e-35
 Identities = 80/181 (44%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+ +L  T  AK        I    KCDF  I  + +     K+ EKK    AE+K
Sbjct: 430 FFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRPIFDYYD----AKRIEKKNLPPAEKK 485

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +      +   L DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 486 RLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKARVQPEQITIN 545

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KF
Sbjct: 546 IGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGLSDYKKF 604

Query: 521 E 523
           E
Sbjct: 605 E 605

[80][TOP]
>UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC
           6260 RepID=UPI000151AE34
          Length = 754

 Score =  149 bits (377), Expect = 9e-35
 Identities = 76/175 (43%), Positives = 109/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           F+ DF  ++ ++  A V +    K DF+++ AH E      K +KK  +  E+K  +EA+
Sbjct: 194 FWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE----MLKEQKKNMSRDEKKALKEAK 249

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    +   L++GR+E VGNFRVEP  LF GRG HP TGK+K+R+ PED+TLNL     
Sbjct: 250 EKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPKTGKLKKRVYPEDITLNLSKECK 309

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +PE P  GH WG++ H++ V WLA WK++I+   KYV  +A S+ KG SD  KFE
Sbjct: 310 VPE-PPAGHKWGEVRHDNTVAWLAMWKENISDSLKYVRFAANSSVKGQSDFKKFE 363

[81][TOP]
>UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO
          Length = 732

 Score =  149 bits (377), Expect = 9e-35
 Identities = 77/177 (43%), Positives = 113/177 (63%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV---ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF ++L     A+    I    KCDFS++ A+++ ++     + K  ++ ERK  ++
Sbjct: 169 FFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQQRV----QMKQLSSHERKLLKQ 224

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
            + +      V L+ GR+E V  F+++P +LF GRG HP TGK+KRR+QPEDV LNL  +
Sbjct: 225 EKGQTEGPVQVLLLTGRKEQVDTFKIDPPDLFRGRGAHPKTGKLKRRVQPEDVVLNLDKD 284

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIPE P  GH WG+I H++ V WL  W+++I+  +KYV L+A S+ KGMSD  KFE
Sbjct: 285 APIPE-PPAGHKWGEIRHDNTVQWLCMWRENISNSFKYVRLAANSSLKGMSDFKKFE 340

[82][TOP]
>UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
           RepID=C7YQG7_NECH7
          Length = 919

 Score =  149 bits (377), Expect = 9e-35
 Identities = 83/181 (45%), Positives = 109/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 163
           FF DF+       + D    KV I SL+KCDF+++  +     AK +  K    T E KE
Sbjct: 343 FFEDFQEYCKKYGVTDADGKKVQIKSLDKCDFTKLADYW---LAKAEQNKTKNMTKEEKE 399

Query: 164 AREAEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           A +A+ E +   FT  + DGR++ VGNFRVEP +LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 400 AAKAKKEALEAPFTHCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKNRVTPEQITIN 459

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A IP+ P  GH W  + H+   TWLA W+++I   YKYV L A S  KG SD  KF
Sbjct: 460 IGKGAKIPD-PPKGHQWKAVQHDQKATWLAMWQENINNNYKYVMLGAASDIKGQSDFKKF 518

Query: 521 E 523
           E
Sbjct: 519 E 519

[83][TOP]
>UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii
           RepID=A5DLX4_PICGU
          Length = 754

 Score =  149 bits (377), Expect = 9e-35
 Identities = 76/175 (43%), Positives = 109/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           F+ DF  ++ ++  A V +    K DF+++ AH E      K +KK  +  E+K  +EA+
Sbjct: 194 FWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE----MLKEQKKNMSRDEKKALKEAK 249

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +    +   L++GR+E VGNFRVEP  LF GRG HP TGK+K+R+ PED+TLNL     
Sbjct: 250 EKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPKTGKLKKRVYPEDITLNLSKECK 309

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +PE P  GH WG++ H++ V WLA WK++I+   KYV  +A S+ KG SD  KFE
Sbjct: 310 VPE-PPAGHKWGEVRHDNTVAWLAMWKENISDSLKYVRFAANSSVKGQSDFKKFE 363

[84][TOP]
>UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii
           CBS767 RepID=UPI00003BE191
          Length = 789

 Score =  149 bits (376), Expect = 1e-34
 Identities = 79/176 (44%), Positives = 109/176 (61%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L D     V I    + DFS++ AH E  + +KK   K     + K+A +AE
Sbjct: 229 FFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAE 283

Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
            ++  + +   L++G +E VGNFR+EP  LF GRG HP TGK+KRR+ PEDVTLNL    
Sbjct: 284 KDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEDVTLNLSEGC 343

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            IPE P  GH W ++ H++ V+WLA WK++I   +KYV  +A S+ KG+SD  KFE
Sbjct: 344 KIPE-PPQGHKWAEVRHDNTVSWLAMWKENIADSFKYVRFAANSSIKGLSDFKKFE 398

[85][TOP]
>UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA
          Length = 789

 Score =  149 bits (376), Expect = 1e-34
 Identities = 79/176 (44%), Positives = 109/176 (61%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF DF  +L D     V I    + DFS++ AH E  + +KK   K     + K+A +AE
Sbjct: 229 FFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAE 283

Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
            ++  + +   L++G +E VGNFR+EP  LF GRG HP TGK+KRR+ PEDVTLNL    
Sbjct: 284 KDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHPKTGKLKRRVMPEDVTLNLSEGC 343

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            IPE P  GH W ++ H++ V+WLA WK++I   +KYV  +A S+ KG+SD  KFE
Sbjct: 344 KIPE-PPQGHKWAEVRHDNTVSWLAMWKENIADSFKYVRFAANSSIKGLSDFKKFE 398

[86][TOP]
>UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624
           RepID=Q0CUT4_ASPTN
          Length = 872

 Score =  149 bits (376), Expect = 1e-34
 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+ +L       D K  KV I   +KCDF  I  + E     K+ EK+    AE+K
Sbjct: 304 FFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIFDYYE----AKRIEKRNLPAAEKK 359

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E+   +   + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 360 RLKAEKDEQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 419

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 420 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 478

Query: 521 E 523
           E
Sbjct: 479 E 479

[87][TOP]
>UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GB81_AJEDR
          Length = 911

 Score =  149 bits (376), Expect = 1e-34
 Identities = 79/181 (43%), Positives = 106/181 (58%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A +  +  AK        I S + CDF  I  + E      + EKK    AE+K
Sbjct: 343 FFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKPIFEYYE----AARLEKKNLPAAEKK 398

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 399 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 458

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 459 IGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 517

Query: 521 E 523
           E
Sbjct: 518 E 518

[88][TOP]
>UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI
          Length = 871

 Score =  149 bits (375), Expect = 1e-34
 Identities = 79/181 (43%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FFADF+ +L  T  AK        I    KCDF  I  + + ++     EKKA   AE+K
Sbjct: 303 FFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQRQ----EKKALPPAEKK 358

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +  +   +   + DGR++ VGNFRVEP  LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 359 RLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPPLFRGRGEHPKTGRVKARVQPEQITIN 418

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 419 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 477

Query: 521 E 523
           E
Sbjct: 478 E 478

[89][TOP]
>UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin
           54-1255 RepID=B6H1W4_PENCW
          Length = 864

 Score =  149 bits (375), Expect = 1e-34
 Identities = 79/181 (43%), Positives = 112/181 (61%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLA------DTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF+DF+ ++       D+K  KV I    KCDF  I    + ++     EK+    AE+K
Sbjct: 295 FFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIFEFYDAQRE----EKRHLPPAEKK 350

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
            A+  + E+   +   + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 351 AAKALKDEQEAPYQYCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKTRVQPEQITIN 410

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KF
Sbjct: 411 IGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDFKKF 469

Query: 521 E 523
           E
Sbjct: 470 E 470

[90][TOP]
>UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01
           RepID=C1H484_PARBA
          Length = 900

 Score =  148 bits (373), Expect = 3e-34
 Identities = 80/181 (44%), Positives = 105/181 (58%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A +  +  AK        I S +KCDF  I    E      + EKKA   AE+K
Sbjct: 332 FFNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKPIFEFYE----AARLEKKALPAAEKK 387

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 388 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 447

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 448 IGKEAKVP-TPPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 506

Query: 521 E 523
           E
Sbjct: 507 E 507

[91][TOP]
>UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana
           B05.10 RepID=A6S3Q9_BOTFB
          Length = 912

 Score =  148 bits (373), Expect = 3e-34
 Identities = 80/181 (44%), Positives = 106/181 (58%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF   +  T  AK        I    K DF  I  + + +  ++KA   A+  AE+ 
Sbjct: 340 FFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIFEYYDGKSTERKARSAAEKKAEKA 399

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
              EAEA     +   + DGR+E VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 400 LKDEAEAP----YKTCIWDGRKEDVGNFRVEPPGLFRGRGEHPKTGKVKLRVTPEQITIN 455

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G +A +P  P  GH W  I H++  TWLA W+++I G YKYV L+A+S+ KG SD  KF
Sbjct: 456 IGKDATVPS-PPEGHKWKAIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDFKKF 514

Query: 521 E 523
           E
Sbjct: 515 E 515

[92][TOP]
>UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina
           RepID=B2AY06_PODAN
          Length = 904

 Score =  147 bits (372), Expect = 3e-34
 Identities = 79/181 (43%), Positives = 107/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DFR +L +T  AK        I    K DF++I  + +     KKA   A+  AE+ 
Sbjct: 332 FFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIFEYYKGLSEAKKARPAAEKKAEKA 391

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E  + EA     +     DGR+E VGNFRVEP  LF GRG+HP TG VK+R+ PE VT+N
Sbjct: 392 EKDKFEAP----YMYCKWDGRKEKVGNFRVEPPGLFRGRGEHPKTGTVKKRVMPEQVTIN 447

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P+ P  GH W  + H++  TWLA W++++ G YKYV L+A S  KG +D+ KF
Sbjct: 448 IGKEAKVPD-PPAGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSTVKGQADYKKF 506

Query: 521 E 523
           E
Sbjct: 507 E 507

[93][TOP]
>UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera
            RepID=UPI0000DB758E
          Length = 973

 Score =  147 bits (371), Expect = 4e-34
 Identities = 69/174 (39%), Positives = 109/174 (62%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF D+R ++ +++  K++  L KC+F  I A+      +K  E+KA T  E+++ +E   
Sbjct: 504  FFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----IQKSEERKAMTKEEKQKIKEKNE 558

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
            E  +++   ++DG +E +GNF++EP  LF GRG+HP  GK+K+R+ PED+ +N   ++ I
Sbjct: 559  EIQKEYGYCIIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRVMPEDILINCSKDSNI 618

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PGH W +I H+  VTWLA W ++I G  KYV L+  S  KG  D  K+E
Sbjct: 619  PK-PPPGHKWKEIRHDPNVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYE 671

[94][TOP]
>UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DC43
          Length = 343

 Score =  147 bits (370), Expect = 6e-34
 Identities = 82/176 (46%), Positives = 109/176 (61%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVI--TSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF D+  +L D      I  T  +KCDF  +  + E EKAKKKA   A+    +K+  EA
Sbjct: 42  FFEDWLKVLQDHPPCNGIKATDFDKCDFRPMYEYFEAEKAKKKATSAAEKKEIKKQKDEA 101

Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
           EA+   +F    +DGR+E VGNFRVEP  LF GRG+HP  G +K R+ PED+ LN+G +A
Sbjct: 102 EAKYTHRF----LDGRKEKVGNFRVEPPGLFRGRGEHPKKGSLKYRVCPEDIALNIGKDA 157

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P P   +PG  W  I H++ VTWLA   ++I   +KYV+L+A S+ KG SD AKFE
Sbjct: 158 PTPIPNIPG-KWKAIQHDNTVTWLATRTENINQSHKYVFLAAGSSLKGRSDMAKFE 212

[95][TOP]
>UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma
           cruzi RepID=Q4DTW1_TRYCR
          Length = 664

 Score =  147 bits (370), Expect = 6e-34
 Identities = 80/176 (45%), Positives = 108/176 (61%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF+ +R +L   K    I  LE CDF  I + HL +       EKK   T E K+    E
Sbjct: 108 FFSSWREIL--DKRQHPIRRLELCDFEPIYQWHLRER------EKKLSRTKEEKKQLRLE 159

Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
           AE+  + +   + DG++E V NFRVEP  LF GRG HP+ GK+K+R++PED+T+N+   +
Sbjct: 160 AEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHPMMGKLKKRVEPEDITINIDEFS 219

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PIP+ P  GH W +++H   VTWLA W+DSI G +KYV L+  SA KG SD  KFE
Sbjct: 220 PIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILGSFKYVMLAPSSAIKGQSDMLKFE 274

[96][TOP]
>UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI
          Length = 871

 Score =  147 bits (370), Expect = 6e-34
 Identities = 78/181 (43%), Positives = 108/181 (59%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FFADF+ +L  T  AK        I    KCD   I  + + ++     EKKA   AE+K
Sbjct: 303 FFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIFQYYDAQRQ----EKKALPPAEKK 358

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  +  +   +   + DGR++ VGNFRVEP +LF GRG+HP TG+VK R+QPE +T+N
Sbjct: 359 RLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKARVQPEQITIN 418

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 419 IGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKF 477

Query: 521 E 523
           E
Sbjct: 478 E 478

[97][TOP]
>UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2
          Length = 745

 Score =  146 bits (369), Expect = 7e-34
 Identities = 75/177 (42%), Positives = 109/177 (61%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF  +L ++        I    +CDF+++  + +     +K +KK  T+ E+K+ R 
Sbjct: 182 FFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ----LQKEQKKQLTSQEKKQIRL 237

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
              +    +    +DGR E VGNF+VEP +LF GRG HP TGK+KRR+ PED+ LNL  +
Sbjct: 238 EREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKD 297

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           AP+P  P  GH WG+I H++ V WLA W+++I   +KYV L+A S+ KG SD+ KFE
Sbjct: 298 APVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFE 353

[98][TOP]
>UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18
           RepID=C1GKM6_PARBD
          Length = 825

 Score =  146 bits (369), Expect = 7e-34
 Identities = 79/181 (43%), Positives = 104/181 (57%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A +  +  AK        I S +KCDF  I    E      + EKKA    E+K
Sbjct: 337 FFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIFEFYE----AARLEKKALPATEKK 392

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 393 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 452

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 453 IGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 511

Query: 521 E 523
           E
Sbjct: 512 E 512

[99][TOP]
>UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0SEQ3_PARBP
          Length = 905

 Score =  146 bits (369), Expect = 7e-34
 Identities = 79/181 (43%), Positives = 104/181 (57%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF A +  +  AK        I S +KCDF  I    E      + EKKA    E+K
Sbjct: 337 FFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIFEFYE----AARLEKKALPATEKK 392

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +  + E    +   + DGR++ VGNFRVEP  LF GRG+HP TGKVK R+ PE +T+N
Sbjct: 393 RLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGKVKTRVMPEQITIN 452

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KF
Sbjct: 453 IGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKF 511

Query: 521 E 523
           E
Sbjct: 512 E 512

[100][TOP]
>UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae
           RepID=B3LJ50_YEAS1
          Length = 769

 Score =  146 bits (369), Expect = 7e-34
 Identities = 75/177 (42%), Positives = 109/177 (61%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF  +L ++        I    +CDF+++  + +     +K +KK  T+ E+K+ R 
Sbjct: 206 FFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ----LQKEQKKQLTSQEKKQIRL 261

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
              +    +    +DGR E VGNF+VEP +LF GRG HP TGK+KRR+ PED+ LNL  +
Sbjct: 262 EREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKD 321

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           AP+P  P  GH WG+I H++ V WLA W+++I   +KYV L+A S+ KG SD+ KFE
Sbjct: 322 APVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFE 377

[101][TOP]
>UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae
           RepID=TOP1_YEAST
          Length = 769

 Score =  146 bits (369), Expect = 7e-34
 Identities = 75/177 (42%), Positives = 109/177 (61%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF  +L ++        I    +CDF+++  + +     +K +KK  T+ E+K+ R 
Sbjct: 206 FFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ----LQKEQKKQLTSQEKKQIRL 261

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
              +    +    +DGR E VGNF+VEP +LF GRG HP TGK+KRR+ PED+ LNL  +
Sbjct: 262 EREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKD 321

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           AP+P  P  GH WG+I H++ V WLA W+++I   +KYV L+A S+ KG SD+ KFE
Sbjct: 322 APVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFE 377

[102][TOP]
>UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei
           RepID=Q581U8_9TRYP
          Length = 661

 Score =  146 bits (368), Expect = 1e-33
 Identities = 78/174 (44%), Positives = 103/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF  +R +L   K    I  LE CDFS I    + E  K+K+    +T  E+KE +    
Sbjct: 133 FFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVEKRKS----RTREEKKELKRIAD 186

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E    +   + +G++E V NFRVEP  LF GRG+HP+ GK+K+RI PEDV LN+G  API
Sbjct: 187 EEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMRGKLKKRILPEDVVLNIGKEAPI 246

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W  ++H+  VTWLA W +   G  KYV L+  S  KG SD+AKFE
Sbjct: 247 PQAPA-GHKWKGVVHDQNVTWLAMWYEPTIGQCKYVMLAPSSTLKGQSDYAKFE 299

[103][TOP]
>UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma
           brucei RepID=C9ZLY6_TRYBG
          Length = 696

 Score =  146 bits (368), Expect = 1e-33
 Identities = 78/174 (44%), Positives = 103/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF  +R +L   K    I  LE CDFS I    + E  K+K+    +T  E+KE +    
Sbjct: 168 FFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVEKRKS----RTREEKKELKRIAD 221

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E    +   + +G++E V NFRVEP  LF GRG+HP+ GK+K+RI PEDV LN+G  API
Sbjct: 222 EEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMRGKLKKRILPEDVVLNIGKEAPI 281

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W  ++H+  VTWLA W +   G  KYV L+  S  KG SD+AKFE
Sbjct: 282 PQAPA-GHKWKGVVHDQNVTWLAMWYEPTIGQCKYVMLAPSSTLKGQSDYAKFE 334

[104][TOP]
>UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea
           RepID=A4R0K7_MAGGR
          Length = 906

 Score =  146 bits (368), Expect = 1e-33
 Identities = 82/181 (45%), Positives = 104/181 (57%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF  F+  L  T  AK        I   EK DF  I  H + +   KKA  K +  AE K
Sbjct: 333 FFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIFQHFQAQSEAKKARSKEEKKAE-K 391

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           EAR+   E    +     DGR+E VGNFRVEP  LF GRG+HP TG +K R+ PE VT+N
Sbjct: 392 EARDKMEE---PYKYCKWDGRKEKVGNFRVEPPALFRGRGEHPKTGTIKERVPPEAVTIN 448

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +PE P  GH W  + H++  TWLA W++++ G YKYV L+A SA KG +D  KF
Sbjct: 449 IGKGAKVPE-PPAGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSAVKGQADFKKF 507

Query: 521 E 523
           E
Sbjct: 508 E 508

[105][TOP]
>UniRef100_A4S5R8 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4S5R8_OSTLU
          Length = 491

 Score =  145 bits (367), Expect = 1e-33
 Identities = 78/175 (44%), Positives = 102/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F   F+A L +   A  IT   KCDF+++  H    + KKK      T+ E+K  +  + 
Sbjct: 16  FMDGFKAALKNGPHA-FITDFSKCDFTKMYMHFLAIREKKKE----MTSEEKKRIKAQKD 70

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
                +T A +DGR E VGNFRVEP  LF GRG+HP  GK+KRR+ PED+T+N+G +A +
Sbjct: 71  IDEEPYTWATIDGRREKVGNFRVEPPGLFRGRGEHPKMGKIKRRVVPEDITINIGKDAKV 130

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P  GH+W  +IHN   TWLAGW D I    +KYV   A S  K  SD  K+E
Sbjct: 131 PE-PPAGHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYE 184

[106][TOP]
>UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR
          Length = 664

 Score =  145 bits (367), Expect = 1e-33
 Identities = 79/176 (44%), Positives = 108/176 (61%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF+ +R +L   +    I  LE CDF  I + HL +       EKK   T E K+    E
Sbjct: 108 FFSSWREILDRRQHP--IRRLELCDFEPIYQWHLRER------EKKLSRTKEEKKQLRLE 159

Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
           AE+  + +   + DG++E V NFRVEP  LF GRG HP+ GK+K+R++PED+T+N+   +
Sbjct: 160 AEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHPMMGKLKKRVEPEDITINIDEFS 219

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PIP+ P  GH W +++H   VTWLA W+DSI G +KYV L+  SA KG SD  KFE
Sbjct: 220 PIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILGSFKYVMLAPSSAIKGQSDMLKFE 274

[107][TOP]
>UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi
           RepID=A8Q2Z1_BRUMA
          Length = 751

 Score =  144 bits (364), Expect = 3e-33
 Identities = 68/174 (39%), Positives = 107/174 (61%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R ++   +  K IT L KCDF  +  H      K + E+++ +  E+++ +E + 
Sbjct: 274 FFTDWRKVMTPAEREK-ITDLTKCDFREMHDHY----IKLREERRSLSKEEKQKLKEIKQ 328

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E  + + VA +DG ++ +GNFR+EP +LF GRG HP  G++K+R+ PEDV +N   ++ I
Sbjct: 329 EEAKIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHPKMGRLKKRVNPEDVIINCSKDSEI 388

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W ++ H++ VTWL  W D+I G  KY+ L+  S  KG  D+ KFE
Sbjct: 389 PK-PPEGHRWKEVRHDNTVTWLCSWTDNILGSIKYIMLNPSSKIKGEKDYEKFE 441

[108][TOP]
>UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299
           RepID=C1FD86_9CHLO
          Length = 635

 Score =  144 bits (363), Expect = 4e-33
 Identities = 75/161 (46%), Positives = 102/161 (63%), Gaps = 4/161 (2%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKK---AEKKAQTTAERKEAREAEAERVRQFTVALVDGR 223
           I   +KCDF++I      E+ +KK   AE+K +  AE+  A E       ++  A +DGR
Sbjct: 187 IKDFKKCDFTKIYMWNLQERERKKSVSAEEKRKVKAEQAAAEE-------KYCWATIDGR 239

Query: 224 EETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKII 403
            E VGN++VEP  LF GRG+HP  G+VK+RI PED+ +N+G  A +PE P+PGH W +II
Sbjct: 240 RERVGNYKVEPPGLFRGRGEHPKMGRVKKRIMPEDIIINIGKGAKVPE-PLPGHKWKQII 298

Query: 404 HNSCVTWLAGWKDSI-TGGYKYVWLSAESAFKGMSDHAKFE 523
           HN+ VTWL GW D+I T  +KYV   A S+ K  SD  K+E
Sbjct: 299 HNNTVTWLCGWNDTINTKDWKYVQFGATSSIKAESDIQKYE 339

[109][TOP]
>UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum
           RepID=Q9Y180_LEIIN
          Length = 635

 Score =  144 bits (363), Expect = 4e-33
 Identities = 85/178 (47%), Positives = 106/178 (59%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---EDEKAKKKAEKKAQTTAERKEAR 169
           FF  +R +L   K    I  LE CDF  I + HL   E + ++ K EKKA      KE +
Sbjct: 105 FFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAI-----KEKQ 157

Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
           +AEAE  R     + DGR E V NFRVEP  LF GRG HPL GK+K R+QPED+T+N+G 
Sbjct: 158 DAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGE 214

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            A +P  P  GH W  + H+  VTWLA W+DS+ G  KYV L+  S+ KG SD  KFE
Sbjct: 215 TAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFE 271

[110][TOP]
>UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani
           RepID=Q9NJG8_LEIDO
          Length = 949

 Score =  144 bits (363), Expect = 4e-33
 Identities = 85/178 (47%), Positives = 106/178 (59%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---EDEKAKKKAEKKAQTTAERKEAR 169
           FF  +R +L   K    I  LE CDF  I + HL   E + ++ K EKKA      KE +
Sbjct: 420 FFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAI-----KEKQ 472

Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
           +AEAE  R     + DGR E V NFRVEP  LF GRG HPL GK+K R+QPED+T+N+G 
Sbjct: 473 DAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGE 529

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            A +P  P  GH W  + H+  VTWLA W+DS+ G  KYV L+  S+ KG SD  KFE
Sbjct: 530 TAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFE 586

[111][TOP]
>UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN
          Length = 635

 Score =  144 bits (363), Expect = 4e-33
 Identities = 85/178 (47%), Positives = 106/178 (59%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---EDEKAKKKAEKKAQTTAERKEAR 169
           FF  +R +L   K    I  LE CDF  I + HL   E + ++ K EKKA      KE +
Sbjct: 105 FFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAI-----KEKQ 157

Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
           +AEAE  R     + DGR E V NFRVEP  LF GRG HPL GK+K R+QPED+T+N+G 
Sbjct: 158 DAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGE 214

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            A +P  P  GH W  + H+  VTWLA W+DS+ G  KYV L+  S+ KG SD  KFE
Sbjct: 215 TAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFE 271

[112][TOP]
>UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA
          Length = 785

 Score =  144 bits (363), Expect = 4e-33
 Identities = 77/177 (43%), Positives = 106/177 (59%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           F  DF  +L +   A+    I    K DF++I  + + +K     +KK  +  E+K+ R 
Sbjct: 222 FLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQVQKE----QKKQLSPQEKKQLRL 277

Query: 173 AEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
            + E  + +    +DGR E VGNFR+EP  LF GRG HP  GK+KRR+ PEDV LNL   
Sbjct: 278 EKEELEKPYKFCEIDGRVEQVGNFRIEPPGLFRGRGAHPKNGKLKRRVYPEDVVLNLDKE 337

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           APIPE P  GH WG+I H++ V WL+ W+++I+  +KYV  +A S  KGMSD  KFE
Sbjct: 338 APIPE-PPKGHKWGEIRHDNTVQWLSMWRENISNSFKYVRFAANSTLKGMSDFKKFE 393

[113][TOP]
>UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO
          Length = 1043

 Score =  144 bits (362), Expect = 5e-33
 Identities = 69/175 (39%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +   K  ++I    KC+F  +  + + E  K+KA      T E K A++ E+
Sbjct: 558  FFKDFRKTMTP-KEKEIIKDFRKCNFQEMFEYFQAESEKRKA-----ATKEEKLAKKVES 611

Query: 182  ER-VRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            E  ++++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   DV++N G N+ 
Sbjct: 612  EALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAARDVSINCGKNSK 671

Query: 359  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            +P+ P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 672  VPQ-PPPGERWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYE 725

[114][TOP]
>UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia
            vitripennis RepID=UPI00015B4D8F
          Length = 1019

 Score =  143 bits (361), Expect = 6e-33
 Identities = 70/174 (40%), Positives = 108/174 (62%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF D+R ++ +++ AK IT L+KC+F+ +  +       K  E+KA +  E+K  +E   
Sbjct: 534  FFHDWREVMTESERAK-ITDLKKCNFTEMHKYF----IMKSEERKAMSKEEKKAIKEKND 588

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
            E  +++ +  +DG +E +GNF++EP  LF GRG+HP  GK+K+R+ PEDV +N   ++  
Sbjct: 589  EIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRLVPEDVLINCSKDSVH 648

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PGH W +I H+  VTWLA W ++I G  KYV L+  S  KG  D  K+E
Sbjct: 649  PK-PPPGHKWKEIRHDPTVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYE 701

[115][TOP]
>UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis
           RepID=A4HB62_LEIBR
          Length = 637

 Score =  143 bits (360), Expect = 8e-33
 Identities = 78/174 (44%), Positives = 99/174 (56%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF  +R +L   K    I  LE CDF  I      E+ KK      +T  E+K  +E + 
Sbjct: 105 FFESWREIL--DKRQHPIRRLELCDFEPIYQWYLAEREKKLN----RTKEEKKSIKEKQD 158

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
                +   + DGR E V NFRVEP  LF GRG HPL GK+K R+QPE +T+N+G  A +
Sbjct: 159 MDAEPYRYCMWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKARVQPEGITINIGETAEV 218

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  GH WG + H+  VTWLA W+DS+ G  KYV L+A S+ KG SD  KFE
Sbjct: 219 P-VPPAGHKWGAVQHDHTVTWLAMWRDSVVGNAKYVMLAASSSVKGQSDMMKFE 271

[116][TOP]
>UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio
           RepID=Q6T721_DANRE
          Length = 600

 Score =  142 bits (359), Expect = 1e-32
 Identities = 74/175 (42%), Positives = 107/175 (61%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +  K+IT+L KCDF+ I  +  +     KAE+K   T E K+  + EA
Sbjct: 114 FFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE-----KAEEKKNMTKEEKQVLKDEA 167

Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            R+  +F   L+DG  E +GNF++EP  LF GRG+HP  G++K+RIQPEDV +N   ++ 
Sbjct: 168 ARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCSKDSK 227

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++ H++ VTWLA W ++I    KY+ L+  S  KG  D  K+E
Sbjct: 228 IPE-PPAGHKWKRVQHDNTVTWLASWLENIPKRPKYIMLNPSSKLKGEKDWQKYE 281

[117][TOP]
>UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major
           RepID=Q4Q2K0_LEIMA
          Length = 634

 Score =  142 bits (359), Expect = 1e-32
 Identities = 80/174 (45%), Positives = 102/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF  +R +L   K    I  LE CDF  I      ++ KK +  K +  A  KE ++AEA
Sbjct: 105 FFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQREKKLSRTKEEKKAI-KEKQDAEA 161

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E  R     + DGR E V NFRVEP  LF GRG HPL GK+K R+QPED+T+N+G  A +
Sbjct: 162 EPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEV 218

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  GH W  + H+  VTWLA W+D++ G  KYV L+  S+ KG SD  KFE
Sbjct: 219 P-VPPAGHKWAAVQHDHTVTWLAMWRDNVAGNMKYVMLAPSSSVKGQSDMVKFE 271

[118][TOP]
>UniRef100_A7SLG4 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SLG4_NEMVE
          Length = 502

 Score =  142 bits (359), Expect = 1e-32
 Identities = 70/174 (40%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  + + +  K I  L+ CDF  +  + E     K  E+K  T  E+ E ++   
Sbjct: 16  FFSDWRKEMTEEE-RKHIKDLKNCDFKEMHKYFE----MKNEERKNMTKEEKLEIKKKNE 70

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           E + ++   ++D  ++ VGNF++EP  LF GRGDHP  GK+K+R+ PE+VT+N+G +A +
Sbjct: 71  EILNEYGFCMMDHHKQRVGNFKIEPPGLFRGRGDHPKQGKLKKRVMPEEVTINIGKDAKV 130

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W K+I +  VTWLA W ++I G YKYV L+  S  KG  D  K+E
Sbjct: 131 PD-PPAGHKWKKVICDDTVTWLACWIENIQGSYKYVMLNPTSRLKGEKDWRKYE 183

[119][TOP]
>UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16
           RepID=A8XXL4_CAEBR
          Length = 840

 Score =  142 bits (358), Expect = 1e-32
 Identities = 68/174 (39%), Positives = 110/174 (63%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R L+   +  K IT L KCDF+    H+ + + +++  +KA T  E+ + +E +A
Sbjct: 339 FMKDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNEQREIRKAMTKEEKAKIKEEKA 393

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + V  + +A++DG +E + NFR+EP  +F GRG HP  G +K+RI PEDV +N G ++ I
Sbjct: 394 QEVVDYGIAIIDGHKEKIANFRIEPPGVFRGRGGHPKMGFIKKRIVPEDVIVNCGKDSVI 453

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P+ GH W ++ H++ V+WL  W +S+ G  KY+ L+A S  KG  D+ K+E
Sbjct: 454 PKPPL-GHKWKEVRHDNTVSWLCSWTESVLGQNKYIMLNASSKIKGSKDYEKYE 506

[120][TOP]
>UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186E5D8
          Length = 961

 Score =  142 bits (357), Expect = 2e-32
 Identities = 69/174 (39%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R ++ D K  KVIT L KC+F  +  + ++    K  E+KA +  E+K  ++   
Sbjct: 482 FFNDWRKVMTD-KERKVITDLSKCNFKPMALYFQE----KSEERKAMSKEEKKVIKDQND 536

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              +++    +DG +E +GNFR+EP  LF GRG+HP  G +K+R+ PEDV +N   ++ I
Sbjct: 537 AIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMLKKRVLPEDVIINCSKDSKI 596

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W K+ H+  VTWLA W +++ G  KYV L+  S  KG  D  K+E
Sbjct: 597 PK-PPDGHKWKKVQHDPSVTWLASWTENVQGNVKYVMLNPSSKLKGEKDMVKYE 649

[121][TOP]
>UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN
          Length = 990

 Score =  141 bits (356), Expect = 2e-32
 Identities = 67/174 (38%), Positives = 103/174 (59%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +  +K  ++I    KC+F  +  + + E  K+KA  K +  A++ E      
Sbjct: 519  FFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEKRKAATKEEKLAKKNENEAL-- 575

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              V+++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G  + +
Sbjct: 576  --VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESHV 633

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 634  PS-PPPGQRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 686

[122][TOP]
>UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732
           RepID=C5DTC9_ZYGRC
          Length = 843

 Score =  141 bits (355), Expect = 3e-32
 Identities = 77/178 (43%), Positives = 108/178 (60%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 172
           FF DF  +L +   TK    I S +KCDF+++    E +K ++K     Q + + K+   
Sbjct: 280 FFNDFIEVLNENGGTKNGINIESFDKCDFTKMFEFFEMQKEQRK-----QLSPQEKKQLR 334

Query: 173 AEAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
            E E+  + F    +DGR+E VGNF++EP  LF GRG HP TGK+KRR+ PEDV LNL  
Sbjct: 335 MEREKFEEPFKYCELDGRKEQVGNFKIEPPGLFRGRGAHPKTGKLKRRVYPEDVVLNLDK 394

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +A IP  P  G  WG+I H++ V WLA W+++I+  +KYV  +A S+  G SD  KFE
Sbjct: 395 DATIPPLP-EGQKWGEIRHDNTVQWLAMWRENISNSFKYVRFAANSSLNGQSDFKKFE 451

[123][TOP]
>UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q9Y0_IXOSC
          Length = 499

 Score =  140 bits (353), Expect = 5e-32
 Identities = 68/175 (38%), Positives = 109/175 (62%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   K A++IT L KC+F  I+ +      K+K+E++   + E K+A +A+ 
Sbjct: 292 FFKDWRKTMTP-KEAELITDLSKCNFKEIDVYY-----KQKSEERKAMSKEEKQAIKAQN 345

Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E++  ++   ++DG  + +GNF++EP  LF GRG+HP  G +KRR+ PEDV +N+G  A 
Sbjct: 346 EKLLEEYGFCIIDGHRQKIGNFKIEPPGLFRGRGEHPKMGMLKRRVMPEDVIINIGKEAK 405

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP  P  GH W ++ H++ V+WL+ W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 406 IPP-PPEGHRWKEVRHDNTVSWLSSWTENILGQTKYIMLNPSSKLKGEKDMQKYE 459

[124][TOP]
>UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG
          Length = 622

 Score =  140 bits (352), Expect = 7e-32
 Identities = 73/178 (41%), Positives = 103/178 (57%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKKKAEKKAQTTAERKEAR 169
           FF D+R  + D +   +I  L+KCDF  I    +A +E  K   K EK       RK  +
Sbjct: 104 FFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVEARKNMSKEEKLVCNIQFRKVLK 162

Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
           EA  + + ++   L+D   E +GNF++EP  LF GRG+HP  GK+K+RIQPEDV +N   
Sbjct: 163 EANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGKLKKRIQPEDVIINCSK 222

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            + IP  P  GH W ++ H++ VTWLA W ++I G  KY+ L+A S  KG  D  K+E
Sbjct: 223 ESRIP-VPPAGHRWKEVRHDNTVTWLASWTENIQGSIKYIMLNANSKLKGEKDWEKYE 279

[125][TOP]
>UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR
          Length = 874

 Score =  139 bits (351), Expect = 9e-32
 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 160
           FF DF+ +L  T  AK        I   EK DFS++ A+ + +   K A   A+  AE+ 
Sbjct: 302 FFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWAYKDAQTKAKNARSSAEKKAEKA 361

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E  + +A     +     DGR+E VGN RVE   LF GRGDHP TG +K+R+ PE +T+N
Sbjct: 362 ERDKRDAP----YLYCKWDGRKEKVGNPRVEIPGLFRGRGDHPKTGCIKKRVLPEQITIN 417

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           +G  A +PE P  GH W  + H++  TWLA W+++I G YKYV L+A S  KG +D  KF
Sbjct: 418 IGKEAKVPE-PPAGHKWKAVQHDNKATWLAMWQENINGHYKYVMLAANSTVKGKADFKKF 476

Query: 521 E 523
           E
Sbjct: 477 E 477

[126][TOP]
>UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura
            RepID=B5DMS2_DROPS
          Length = 1054

 Score =  139 bits (350), Expect = 1e-31
 Identities = 68/175 (38%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +  +K  ++I    KC+F  +  + + E     +EK+ Q T E K A++ E 
Sbjct: 569  FFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNEN 622

Query: 182  ER-VRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            E  ++++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   DV++N G  + 
Sbjct: 623  EALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASDVSINCGKESK 682

Query: 359  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            +P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 683  VPP-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 736

[127][TOP]
>UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE
          Length = 1042

 Score =  139 bits (350), Expect = 1e-31
 Identities = 68/175 (38%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +  +K  ++I    KC+F  +  + + E     +EK+ Q T E K A++ E 
Sbjct: 557  FFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNEN 610

Query: 182  ER-VRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            E  ++++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   DV++N G  + 
Sbjct: 611  EALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASDVSINCGKESK 670

Query: 359  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            +P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 671  VPP-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 724

[128][TOP]
>UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I,
           mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens
           RepID=B7ZAR5_HUMAN
          Length = 503

 Score =  139 bits (350), Expect = 1e-31
 Identities = 73/175 (41%), Positives = 108/175 (61%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   +     E K+  + EA
Sbjct: 16  FFSDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 69

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG +E +GNF++EP  LF GRGDHP  G +KRRI PEDV +N   ++ 
Sbjct: 70  EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 129

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE
Sbjct: 130 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 183

[129][TOP]
>UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes
           RepID=TOP1M_PANTR
          Length = 601

 Score =  139 bits (349), Expect = 2e-31
 Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   +     E K+  + EA
Sbjct: 114 FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 167

Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E++ R+F   ++DG +E +GNF++EP  LF GRGDHP  G +KRRI PEDV +N   ++ 
Sbjct: 168 EKLQREFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRIMPEDVVINCSRDSK 227

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE
Sbjct: 228 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 281

[130][TOP]
>UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio
           rerio RepID=UPI0001760D92
          Length = 748

 Score =  138 bits (348), Expect = 2e-31
 Identities = 70/175 (40%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L+KCDF+++  +      K ++E + Q + E K+  + E 
Sbjct: 261 FFKDWRKEMTSEEKSK-ITELKKCDFTQMHEYF-----KAQSEARKQMSKEEKQKNKEEN 314

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   L+D   E +GNFR+EP  LF GRGDHP  GK+KRRI+PED+ +N   ++ 
Sbjct: 315 ERILQEYGFCLMDNHRERIGNFRIEPPGLFRGRGDHPKMGKLKRRIRPEDIIINCSKDSV 374

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 375 QPKAP-PGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 428

[131][TOP]
>UniRef100_B4DYD2 cDNA FLJ50294, highly similar to DNA topoisomerase I, mitochondrial
           (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4DYD2_HUMAN
          Length = 503

 Score =  138 bits (348), Expect = 2e-31
 Identities = 74/175 (42%), Positives = 107/175 (61%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   +     E K+  + EA
Sbjct: 16  FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 69

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG +E +GNF++EP  LF GRGDHP  G +KRRI PEDV +N   ++ 
Sbjct: 70  EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 129

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W +SI    KY+ L+  S  KG +   KFE
Sbjct: 130 IPE-PPAGHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFE 183

[132][TOP]
>UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra
           magnipapillata RepID=UPI000192545C
          Length = 726

 Score =  138 bits (347), Expect = 3e-31
 Identities = 71/175 (40%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAE 178
           FF D+R  +   +   +I SL+KCDF  + A+       K AE+K   T E K+A +EA 
Sbjct: 227 FFEDWRKEMTAEE-RNIIKSLDKCDFKEMHAYF-----MKCAEEKRNMTKEEKQAIKEAN 280

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            +   ++    +DG ++ VGNFR+EP  LF GRGDHP  GK+K+R+  ++V +N+G  A 
Sbjct: 281 LKIAEKYGFCEMDGHKQKVGNFRIEPPGLFRGRGDHPKQGKLKKRVSAKEVIINIGKEAK 340

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +P+ P  G  W  + H++ V+WLA W ++I GGYKYV L+A +  KG  D  K+E
Sbjct: 341 VPQ-PPEGQKWKAVQHDNTVSWLACWVENIAGGYKYVMLNAATRLKGEKDWQKYE 394

[133][TOP]
>UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus
           RepID=UPI00017968A4
          Length = 655

 Score =  138 bits (347), Expect = 3e-31
 Identities = 73/175 (41%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  +   +  K+I  L+KCDF+ I  +  D+ A +KA  +     E K+  + EA
Sbjct: 168 FFSDWRKEMTAEE-RKIIKHLDKCDFTEIHRYFVDKTAARKALSR-----EEKQKLKEEA 221

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F    +DG  E +GNF+ EP  LF GRGDHP  G +KRRI PEDVT+N   ++ 
Sbjct: 222 EKLQQEFGYCTLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRILPEDVTINCSRDSK 281

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP+ P  GH W ++  ++ VTWLA W ++I    KYV L+  S  KG  D  K+E
Sbjct: 282 IPK-PPAGHQWKEVRSDNTVTWLASWTENIQNSIKYVMLNPSSKLKGEKDWQKYE 335

[134][TOP]
>UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A48
          Length = 632

 Score =  138 bits (347), Expect = 3e-31
 Identities = 73/174 (41%), Positives = 101/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + D +   +I  L KCDF  I A     KAK +A K   T  E++  +EA  
Sbjct: 144 FFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKAKVEARKN-MTKEEKQALKEANQ 198

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + V +F   L+D   E +GNF++EP  LF GRG+HP  G +K+RIQPED+ +N    A I
Sbjct: 199 KIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGMLKKRIQPEDIIINCSKEACI 258

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  GH W ++ H++ VTWL  W ++I G  KY+ L+A S  KG  D  K+E
Sbjct: 259 P-VPPAGHRWKEVRHDNTVTWLVSWTENIQGSIKYIMLNANSKLKGEKDWEKYE 311

[135][TOP]
>UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI
          Length = 997

 Score =  138 bits (347), Expect = 3e-31
 Identities = 65/174 (37%), Positives = 102/174 (58%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  + D +  ++I    KC+F  +    + E  ++KA  K +  A++ E      
Sbjct: 512  FFKDFRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAESERRKAATKDEKLAKKNENEAL-- 568

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              V+++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   +V++N G N+ +
Sbjct: 569  --VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIGASEVSINCGKNSKV 626

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 627  P-TPPPGQRWKEVRHDNTVTWLASWVENVQGQVKYIMLNPSSKLKGEKDHIKYE 679

[136][TOP]
>UniRef100_B7Z9E8 cDNA, FLJ78812, highly similar to DNA topoisomerase I,
           mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens
           RepID=B7Z9E8_HUMAN
          Length = 503

 Score =  138 bits (347), Expect = 3e-31
 Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   +     E K+  + EA
Sbjct: 16  FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 69

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG +E +GNF++EP  LF GRGDHP  G +KRRI PEDV +N   ++ 
Sbjct: 70  EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 129

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE
Sbjct: 130 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 183

[137][TOP]
>UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens
           RepID=TOP1M_HUMAN
          Length = 601

 Score =  138 bits (347), Expect = 3e-31
 Identities = 73/175 (41%), Positives = 107/175 (61%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   +     E K+  + EA
Sbjct: 114 FFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR-----EEKQKLKEEA 167

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG +E +GNF++EP  LF GRGDHP  G +KRRI PEDV +N   ++ 
Sbjct: 168 EKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSK 227

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE
Sbjct: 228 IPE-PPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFE 281

[138][TOP]
>UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B1
          Length = 751

 Score =  137 bits (346), Expect = 3e-31
 Identities = 71/174 (40%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +KA T  E+ + +E   
Sbjct: 264 FFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-RKAMTKEEKLKIKEENE 318

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++QF   ++D  +E + NFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++  
Sbjct: 319 RILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKY 378

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 379 PE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 431

[139][TOP]
>UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B0
          Length = 751

 Score =  137 bits (346), Expect = 3e-31
 Identities = 71/174 (40%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +KA T  E+ + +E   
Sbjct: 264 FFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-RKAMTKEEKLKIKEENE 318

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++QF   ++D  +E + NFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++  
Sbjct: 319 RILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKY 378

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 379 PE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 431

[140][TOP]
>UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster
           RepID=Q8IR39_DROME
          Length = 581

 Score =  137 bits (346), Expect = 3e-31
 Identities = 65/174 (37%), Positives = 102/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DFR  +   +  ++I    KC+F  +  + + E  K+KA  K +   ++ E      
Sbjct: 110 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 166

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G ++ +
Sbjct: 167 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 224

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 225 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 277

[141][TOP]
>UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster
            RepID=Q494M1_DROME
          Length = 974

 Score =  137 bits (346), Expect = 3e-31
 Identities = 65/174 (37%), Positives = 102/174 (58%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +   +  ++I    KC+F  +  + + E  K+KA  K +   ++ E      
Sbjct: 503  FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 559

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G ++ +
Sbjct: 560  --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 617

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 618  PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 670

[142][TOP]
>UniRef100_Q1WWG8 IP16129p (Fragment) n=1 Tax=Drosophila melanogaster
           RepID=Q1WWG8_DROME
          Length = 382

 Score =  137 bits (346), Expect = 3e-31
 Identities = 65/174 (37%), Positives = 102/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DFR  +   +  ++I    KC+F  +  + + E  K+KA  K +   ++ E      
Sbjct: 16  FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 72

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G ++ +
Sbjct: 73  --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 130

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 131 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 183

[143][TOP]
>UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME
          Length = 581

 Score =  137 bits (346), Expect = 3e-31
 Identities = 65/174 (37%), Positives = 102/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DFR  +   +  ++I    KC+F  +  + + E  K+KA  K +   ++ E      
Sbjct: 110 FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 166

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G ++ +
Sbjct: 167 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 224

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 225 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 277

[144][TOP]
>UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster RepID=TOP1_DROME
          Length = 972

 Score =  137 bits (346), Expect = 3e-31
 Identities = 65/174 (37%), Positives = 102/174 (58%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +   +  ++I    KC+F  +  + + E  K+KA  K +   ++ E      
Sbjct: 501  FFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 557

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G ++ +
Sbjct: 558  --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKV 615

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 616  PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 668

[145][TOP]
>UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1
           Tax=Tribolium castaneum RepID=UPI00017582B6
          Length = 936

 Score =  137 bits (345), Expect = 4e-31
 Identities = 67/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA-REAE 178
           FF D+R ++++++  KVI  L+KC+F  + A+  D      AEK    T E K+A +E  
Sbjct: 451 FFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMD-----LAEKNRNRTKEEKQALKEKN 504

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
              ++++    +DG +E +GNF++EP  LF GRG+HP  G +KRR++ ED+ +N   ++ 
Sbjct: 505 EALIKEYGFCNIDGHKEKIGNFKIEPPGLFRGRGEHPKMGMLKRRVEAEDIIINCSQDSK 564

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P PGH W ++ H+  VTWLA W +++    KY+ L+  S  KG  D  K+E
Sbjct: 565 IPE-PPPGHKWKEVRHDDNVTWLASWTENVQNQVKYIMLNPSSKLKGEKDWQKYE 618

[146][TOP]
>UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI
          Length = 1045

 Score =  137 bits (344), Expect = 6e-31
 Identities = 65/174 (37%), Positives = 100/174 (57%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +   K  ++I    KC+F  +      E  K+KA  K +  A++ E      
Sbjct: 560  FFKDFRKSMTP-KEKEIIKDFRKCNFQEMHQFFLAESEKRKAATKEEKLAKKNENEAL-- 616

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              ++++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   DV++N G  + +
Sbjct: 617  --IKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAAADVSINCGKQSKV 674

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 675  PQ-PPPGERWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYE 727

[147][TOP]
>UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER
          Length = 969

 Score =  137 bits (344), Expect = 6e-31
 Identities = 66/174 (37%), Positives = 101/174 (58%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +  +K  ++I    KC F+ +    + E  K+KA  K +   ++ E      
Sbjct: 498  FFKDFRKSMT-SKEREIIKDFRKCGFNEMFNFFQAESEKRKAATKEEKLIKKNENEAL-- 554

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G  + +
Sbjct: 555  --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESKV 612

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 613  PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 665

[148][TOP]
>UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans
           RepID=O17966-2
          Length = 734

 Score =  137 bits (344), Expect = 6e-31
 Identities = 69/174 (39%), Positives = 107/174 (61%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R ++   +  + I  L+KCDF  I+A+ ++++  +KA  K +   + KE +EAE 
Sbjct: 248 FMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQREIRKAMTKEEKL-KIKEEKEAE- 304

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             V+ + +A++DG  + V NFR+EP  +F GRG HP  G +K+RI PEDV +N G +  I
Sbjct: 305 --VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEI 362

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P PGH W ++ H++ VTWL  W +S+ G  KY+ L+  S  KG  D  K+E
Sbjct: 363 PK-PPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYE 415

[149][TOP]
>UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL
          Length = 806

 Score =  137 bits (344), Expect = 6e-31
 Identities = 69/174 (39%), Positives = 107/174 (61%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R ++   +  + I  L+KCDF  I+A+ ++++  +KA  K +   + KE +EAE 
Sbjct: 320 FMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQREIRKAMTKEEKL-KIKEEKEAE- 376

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             V+ + +A++DG  + V NFR+EP  +F GRG HP  G +K+RI PEDV +N G +  I
Sbjct: 377 --VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEI 434

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P PGH W ++ H++ VTWL  W +S+ G  KY+ L+  S  KG  D  K+E
Sbjct: 435 PK-PPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYE 487

[150][TOP]
>UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5C65
          Length = 755

 Score =  136 bits (343), Expect = 8e-31
 Identities = 69/174 (39%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +KA T  E+ + +E   
Sbjct: 268 FFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEENE 322

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++Q+   ++D  +E + NFR+EP  LF GRGDHP  G +KRRI+P+D+ +N   ++  
Sbjct: 323 RLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPQDIIINCSKDSKY 382

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 383 PE-PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 435

[151][TOP]
>UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU
          Length = 753

 Score =  136 bits (343), Expect = 8e-31
 Identities = 69/174 (39%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +KA T  E+ + +E   
Sbjct: 266 FFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEENE 320

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++Q+   ++D  +E + NFR+EP  LF GRGDHP  G +KRRI+P+D+ +N   ++  
Sbjct: 321 RLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPQDIIINCSKDSKY 380

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 381 PE-PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 433

[152][TOP]
>UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA
          Length = 580

 Score =  136 bits (343), Expect = 8e-31
 Identities = 66/174 (37%), Positives = 100/174 (57%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DFR  +  +K  ++I    KC F  +    + E  K+KA  K +   ++ E      
Sbjct: 109 FFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEKRKAATKEEKLIKKNENEAL-- 165

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRIQ  DV++N G  + +
Sbjct: 166 --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKESKV 223

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 224 PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 276

[153][TOP]
>UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6JVY3_SCHJY
          Length = 654

 Score =  136 bits (343), Expect = 8e-31
 Identities = 68/157 (43%), Positives = 94/157 (59%), Gaps = 2/157 (1%)
 Frame = +2

Query: 2   FFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF DF+A+   A  K A +      CDF  +  + E  K  KK   K     E+KE ++ 
Sbjct: 301 FFRDFQAVCKEAGMKSADIPKEFNSCDFRPMFEYFESLKEAKKNMSKE----EKKELKKK 356

Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
           + E   +F   L+DGR+E VGNFR+EP  LF GRG HP TG +KRR+ PE +T+N+G  A
Sbjct: 357 KEEEEEKFKWCLLDGRKEKVGNFRIEPPGLFRGRGSHPKTGTLKRRVYPEQITINIGKGA 416

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKY 466
            +PE P+PGH W ++ H+  VTWLA W +++ G  KY
Sbjct: 417 KVPE-PLPGHKWAEVRHDDQVTWLAMWHENVNGNVKY 452

[154][TOP]
>UniRef100_Q4V7M4 MGC115546 protein n=1 Tax=Xenopus laevis RepID=Q4V7M4_XENLA
          Length = 503

 Score =  135 bits (341), Expect = 1e-30
 Identities = 66/174 (37%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +   VIT L+KCDF+ +  + +     K  EKK ++  ++ + +E   
Sbjct: 16  FFVDWRKEMT-LEEKMVITDLDKCDFTEMFTYYKG----KMEEKKNKSKEDKLKIKEENE 70

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + + ++    +D   E +GNF++EP  LF GRGDHP  G +K+RI PED+ +N   ++ I
Sbjct: 71  KLLEEYGYCAMDHHREKIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKI 130

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PGH W ++ H++ VTWLA W +++ G  KY+ L+A S  KG  D  K+E
Sbjct: 131 PE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYE 183

[155][TOP]
>UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PY85_MALGO
          Length = 877

 Score =  135 bits (341), Expect = 1e-30
 Identities = 74/176 (42%), Positives = 97/176 (55%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF DF   L     K    I   EK DF  +  +    K  +   KK+   + RK    A
Sbjct: 183 FFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSMRKAELAA 242

Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
                 ++ + LVDG E+  GN  VEP  LFLGRG HP  G+VK RIQPE +T+N   + 
Sbjct: 243 RRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGAHPKAGRVKTRIQPEQITINHSADH 302

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P P+ P  GH+WG+++    VTWLA W+++I GG+KYV+L A S FK  SD  KFE
Sbjct: 303 PPPK-PPKGHSWGEVVERKDVTWLALWRENINGGFKYVFLDASSTFKTESDREKFE 357

[156][TOP]
>UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus
           RepID=UPI0000ECD01B
          Length = 593

 Score =  135 bits (339), Expect = 2e-30
 Identities = 69/175 (39%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +  ++I  L+KCDF  I  +  D+   +KA  K     E K+  + EA
Sbjct: 106 FFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEARKALSK-----EEKQKLKEEA 159

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           +++++ +   ++DG  E +GNF+ EP  LF GRGDHP  G +K+RI PEDV +N   ++ 
Sbjct: 160 DKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKKRIMPEDVIINCSKDSK 219

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE PV GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  KFE
Sbjct: 220 IPEPPV-GHKWKEVRFDNTVTWLASWTENIQNSLKYIMLNPSSKLKGEKDWQKFE 273

[157][TOP]
>UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus
           RepID=Q6T722_CHICK
          Length = 593

 Score =  135 bits (339), Expect = 2e-30
 Identities = 69/175 (39%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +  ++I  L+KCDF  I  +  D+   +KA  K     E K+  + EA
Sbjct: 106 FFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEARKALSK-----EEKQKLKEEA 159

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           +++++ +   ++DG  E +GNF+ EP  LF GRGDHP  G +K+RI PEDV +N   ++ 
Sbjct: 160 DKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKKRIMPEDVIINCSKDSK 219

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE PV GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  KFE
Sbjct: 220 IPEPPV-GHKWKEVRFDNTVTWLASWTENIQNSLKYIMLNPSSKLKGEKDWQKFE 273

[158][TOP]
>UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE
          Length = 970

 Score =  135 bits (339), Expect = 2e-30
 Identities = 64/174 (36%), Positives = 100/174 (57%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +   +  ++I    KC F  +  + + E  K+KA  K +   ++ E      
Sbjct: 499  FFKDFRKSMTPRE-REIIKDFRKCGFQEMFNYFQAESEKRKAASKEEKLIKKNENEAL-- 555

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              +++F   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   DV++N G ++ +
Sbjct: 556  --MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIHASDVSINCGKDSKV 613

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 614  PS-PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYE 666

[159][TOP]
>UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR
          Length = 767

 Score =  135 bits (339), Expect = 2e-30
 Identities = 63/174 (36%), Positives = 103/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   VIT+L KCDF+++  + +D+   +K   K     E+ + +E   
Sbjct: 280 FFKDWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSEARKQMSKE----EKLKIKEENE 334

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 335 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[160][TOP]
>UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus
           RepID=TOP1M_RAT
          Length = 593

 Score =  135 bits (339), Expect = 2e-30
 Identities = 70/175 (40%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D++  +   +  K+IT L+KCDFS I  H  +     +AE +     E+K+  + EA
Sbjct: 107 FFSDWQKEMTAEE-RKLITHLDKCDFSEIHRHFME-----RAEARRTLPREQKQKLKEEA 160

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG  E +GNF+ EP  LF GRGDHP  G +KRR+ PEDV +N   ++ 
Sbjct: 161 EKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSK 220

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ V WLA W ++I   +KY+ L+  S  KG  D  K+E
Sbjct: 221 IPE-PPAGHQWKEVRSDNTVMWLAAWVENIQNSFKYIILNPSSKPKGEMDWQKYE 274

[161][TOP]
>UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio
           RepID=UPI000176075D
          Length = 531

 Score =  134 bits (338), Expect = 3e-30
 Identities = 70/175 (40%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R  +   +  ++I  L+KCDF  + A H E  +A+K   K+     E+   +EA 
Sbjct: 44  FFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKE-----EKLVNKEAN 97

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            + V ++   ++D   E +GNF++EP  LF GRGDHP  G +K+RI+PEDV +N    + 
Sbjct: 98  QKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPKQGMLKKRIRPEDVIINCSKESR 157

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++ H+  VTWLA W +++ G  KYV L+A S  KG  D  K+E
Sbjct: 158 IPEAPA-GHKWKEVRHDKTVTWLASWTENVQGSCKYVMLNANSKLKGEKDWEKYE 211

[162][TOP]
>UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1
           Tax=Ornithorhynchus anatinus RepID=UPI0001555600
          Length = 689

 Score =  134 bits (338), Expect = 3e-30
 Identities = 70/175 (40%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  +   +  K I  LE+CDF+ I  +  D+   +KA  K     E K+  + EA
Sbjct: 202 FFSDWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNEARKALPK-----EEKQKLKEEA 255

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E++++ F   ++DG  E +GNF+ EP  LF GRGDHP  G +K+RI PEDV +N   ++ 
Sbjct: 256 EKLQEEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGLLKKRIMPEDVIINCSKDSK 315

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  K+E
Sbjct: 316 IPE-PPSGHKWKEVRFDNTVTWLASWTENIQNSIKYIMLNPSSKLKGEKDWQKYE 369

[163][TOP]
>UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C88D
          Length = 609

 Score =  134 bits (338), Expect = 3e-30
 Identities = 70/175 (40%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D+R  +   +  ++I  L+KCDF  + A H E  +A+K   K+     E+   +EA 
Sbjct: 122 FFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKE-----EKLVNKEAN 175

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            + V ++   ++D   E +GNF++EP  LF GRGDHP  G +K+RI+PEDV +N    + 
Sbjct: 176 QKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPKQGMLKKRIRPEDVIINCSKESR 235

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++ H+  VTWLA W +++ G  KYV L+A S  KG  D  K+E
Sbjct: 236 IPEAPA-GHKWKEVRHDKTVTWLASWTENVQGSCKYVMLNANSKLKGEKDWEKYE 289

[164][TOP]
>UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA
          Length = 1019

 Score =  134 bits (336), Expect = 5e-30
 Identities = 74/176 (42%), Positives = 96/176 (54%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF DF+  L     +    I S +K DF  +  +    K  +   KKA   + RK   E 
Sbjct: 224 FFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEE 283

Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
                 ++ + LVDG E+ VGN  VEP  LFLGRG HP  GKVKRRI P D+T+N   + 
Sbjct: 284 RKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADH 343

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P P+ P    +W +++    VTWLA WK++I G YKYV+L A S FK  SD  KFE
Sbjct: 344 PAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFE 399

[165][TOP]
>UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155C8C4
          Length = 781

 Score =  133 bits (335), Expect = 6e-30
 Identities = 64/174 (36%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + + +  IT+L KCDF+ +  +    KA+ +A K+  +  E+++ +E   
Sbjct: 294 FFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF---KAQSEARKQ-MSKEEKQKIKEENE 348

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NFR+EP  LF GRG+HP  G +KRRIQPED+ +N   ++ +
Sbjct: 349 QLLKEYGFCVMDNHRERIANFRIEPPGLFRGRGNHPKMGMLKRRIQPEDIIINCSKDSKV 408

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 409 PP-PPPGHRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 461

[166][TOP]
>UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1DB6
          Length = 770

 Score =  133 bits (335), Expect = 6e-30
 Identities = 69/175 (39%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+  + E 
Sbjct: 283 FFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEEN 336

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++ 
Sbjct: 337 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 396

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 397 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 450

[167][TOP]
>UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG
          Length = 783

 Score =  133 bits (335), Expect = 6e-30
 Identities = 69/175 (39%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+  + E 
Sbjct: 264 FFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEEN 317

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++ 
Sbjct: 318 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 377

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 378 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 431

[168][TOP]
>UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG
           RepID=B9Q6S5_TOXGO
          Length = 953

 Score =  133 bits (335), Expect = 6e-30
 Identities = 69/167 (41%), Positives = 99/167 (59%)
 Frame = +2

Query: 23  LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 202
           L  + K  + +     CDFS I+ +L+    K+K  KK  +  E++  ++ + +    + 
Sbjct: 392 LATEYKEGERMVGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYA 447

Query: 203 VALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382
            ALVD   E VGN RVEP  LF GRG+HP  G +KRRI   DV LNL  +AP+P   +PG
Sbjct: 448 YALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPG 507

Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           H W  + H++ VTWLA ++DSI    KY++L+A+S FKG  D  K+E
Sbjct: 508 HAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYE 554

[169][TOP]
>UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1
           RepID=B9PWF4_TOXGO
          Length = 953

 Score =  133 bits (335), Expect = 6e-30
 Identities = 69/167 (41%), Positives = 99/167 (59%)
 Frame = +2

Query: 23  LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 202
           L  + K  + +     CDFS I+ +L+    K+K  KK  +  E++  ++ + +    + 
Sbjct: 392 LATEYKEGERMVGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYA 447

Query: 203 VALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382
            ALVD   E VGN RVEP  LF GRG+HP  G +KRRI   DV LNL  +AP+P   +PG
Sbjct: 448 YALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPG 507

Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           H W  + H++ VTWLA ++DSI    KY++L+A+S FKG  D  K+E
Sbjct: 508 HAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYE 554

[170][TOP]
>UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49
           RepID=B6KM03_TOXGO
          Length = 953

 Score =  133 bits (335), Expect = 6e-30
 Identities = 69/167 (41%), Positives = 99/167 (59%)
 Frame = +2

Query: 23  LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 202
           L  + K  + +     CDFS I+ +L+    K+K  KK  +  E++  ++ + +    + 
Sbjct: 392 LATEYKEGERMVGFAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYA 447

Query: 203 VALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382
            ALVD   E VGN RVEP  LF GRG+HP  G +KRRI   DV LNL  +AP+P   +PG
Sbjct: 448 YALVDFIREKVGNTRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPG 507

Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           H W  + H++ VTWLA ++DSI    KY++L+A+S FKG  D  K+E
Sbjct: 508 HAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYE 554

[171][TOP]
>UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR
          Length = 1063

 Score =  133 bits (335), Expect = 6e-30
 Identities = 64/174 (36%), Positives = 100/174 (57%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF DFR  +   K  ++I    KC+F  +    + E  K+KA  K +   ++ E      
Sbjct: 578  FFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEKRKAATKEEKLLKKNENEAL-- 634

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              V+++   ++DG +E +GNFR+EP  LF GRG+HP  G +KRRI   DV++N G  + +
Sbjct: 635  --VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIAAADVSINCGKQSKV 692

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P+ G  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E
Sbjct: 693  PQPPM-GGRWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYE 745

[172][TOP]
>UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3S6N7_TRIAD
          Length = 560

 Score =  133 bits (335), Expect = 6e-30
 Identities = 70/177 (39%), Positives = 105/177 (59%), Gaps = 3/177 (1%)
 Frame = +2

Query: 2   FFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           F+ DFR  +  A+    KV +   KCDFS+I      E  K KAE++   + E K   + 
Sbjct: 73  FWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EYYKMKAEERRNMSKEEKNKLKK 124

Query: 176 EAERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPN 352
           E E + Q +   ++DG  + VGNF++EP  LF GRGDHP  GK+KRRI+ +D+ +N+G +
Sbjct: 125 ENEELMQEYGFCIIDGHRQRVGNFKIEPPGLFRGRGDHPKQGKIKRRIEAKDIIINIGKD 184

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           A +P  P PG  W ++ +++ VTWLA W ++I G  KY+ L+  S  K   D+ K+E
Sbjct: 185 AKLP-APPPGQKWKEVRYDNKVTWLASWTENINGSIKYIMLNPTSKIKAEKDYQKYE 240

[173][TOP]
>UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus
           RepID=TOP1M_MOUSE
          Length = 593

 Score =  133 bits (335), Expect = 6e-30
 Identities = 70/175 (40%), Positives = 104/175 (59%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  +   +  ++IT L+KCDF+ I  H  +     +AE +     E+K+  + EA
Sbjct: 107 FFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE-----RAEARRTLPREQKQKLKEEA 160

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG  E +GNF+ EP  LF GRGDHP  G +KRR+ PEDV +N   ++ 
Sbjct: 161 EKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSK 220

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ V WLA W + I   +KYV L+  S  KG  D  K+E
Sbjct: 221 IPE-PPAGHQWKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYE 274

[174][TOP]
>UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata
           RepID=UPI000194D872
          Length = 775

 Score =  133 bits (334), Expect = 8e-30
 Identities = 66/175 (37%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +    ITSL KCDF+ +  +      K ++E + Q + E K+  + E 
Sbjct: 288 FFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQSEARKQMSKEEKQKIKEEN 341

Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ +++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   ++ 
Sbjct: 342 ERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDSK 401

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 402 IP-APPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 455

[175][TOP]
>UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus
           caballus RepID=UPI0001797824
          Length = 765

 Score =  133 bits (334), Expect = 8e-30
 Identities = 64/174 (36%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +ITSL KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 278 FFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 332

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 333 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445

[176][TOP]
>UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum
           RepID=UPI0001792028
          Length = 1011

 Score =  133 bits (334), Expect = 8e-30
 Identities = 65/174 (37%), Positives = 101/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F  D+R  +   K  ++IT L  C+F  +  +      KK  E+KA +  E+K+ +E   
Sbjct: 262 FLKDWRKTMTP-KEKELITDLSLCNFKEMNVYF----TKKSEERKAMSKEEKKKIKEENE 316

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
              +++    +DG +E +GNF++EP  LF GRG+HP  G +K+R+ PEDV +N   ++ I
Sbjct: 317 ALQKEYGFCTIDGHKEKIGNFKIEPPGLFRGRGEHPKMGMLKKRVVPEDVLINCSKDSNI 376

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P PGH W ++ H+  VTWLA W +++ G  KYV L+  S  KG  D  K+E
Sbjct: 377 PK-PPPGHKWKEVRHDFGVTWLASWIENVQGQVKYVMLNPSSKLKGEKDWQKYE 429

[177][TOP]
>UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta
           RepID=UPI00006D45A8
          Length = 767

 Score =  133 bits (334), Expect = 8e-30
 Identities = 63/174 (36%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 280 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 334

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 335 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[178][TOP]
>UniRef100_UPI000069F011 UPI000069F011 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069F011
          Length = 503

 Score =  133 bits (334), Expect = 8e-30
 Identities = 65/174 (37%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           +F D+R  +   +   VIT L KCDF+ +  + +     K  EKK ++  ++ + +E   
Sbjct: 16  YFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKNKSKEDKLKIKEENE 70

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++    +D   E +GNF++EP  LF GRGDHP  G +K+RI PED+ +N   ++ I
Sbjct: 71  KLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKI 130

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PGH W ++ H++ VTWLA W +++ G  KY+ L+A S  KG  D  K+E
Sbjct: 131 PE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYE 183

[179][TOP]
>UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=Q0V9D3_XENTR
          Length = 495

 Score =  133 bits (334), Expect = 8e-30
 Identities = 65/174 (37%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           +F D+R  +   +   VIT L KCDF+ +  + +     K  EKK ++  ++ + +E   
Sbjct: 194 YFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKNKSKEDKLKIKEENE 248

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++    +D   E +GNF++EP  LF GRGDHP  G +K+RI PED+ +N   ++ I
Sbjct: 249 KLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRILPEDIIINCSKDSKI 308

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P PGH W ++ H++ VTWLA W +++ G  KY+ L+A S  KG  D  K+E
Sbjct: 309 PE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYE 361

[180][TOP]
>UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA
          Length = 560

 Score =  133 bits (334), Expect = 8e-30
 Identities = 63/174 (36%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 73  FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 127

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 128 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 187

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 188 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 240

[181][TOP]
>UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus
           RepID=B0WA62_CULQU
          Length = 962

 Score =  133 bits (334), Expect = 8e-30
 Identities = 68/174 (39%), Positives = 102/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +  ++  K I  L+KC+F  + A+  D   K +   K +  A  KE  EA  
Sbjct: 480 FFKDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSEKNRNRSKEEKLA-LKEQNEA-- 535

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             V+++ +  +DG +E +GNFR+EP  LF GRG+HP  G VKRR+ PEDV +N   ++  
Sbjct: 536 -LVKEYGICNIDGHKEKIGNFRIEPPGLFRGRGEHPKMGLVKRRVMPEDVIINCAKDSVY 594

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W ++ H++ V+WLA W +++ G  KYV L+  S  KG  D  K+E
Sbjct: 595 PKAP-EGHRWKEVRHDNTVSWLASWTENVQGQVKYVMLNPSSKLKGEKDWQKYE 647

[182][TOP]
>UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus
           scrofa RepID=UPI00017EFDA4
          Length = 748

 Score =  132 bits (333), Expect = 1e-29
 Identities = 63/174 (36%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 262 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 316

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 317 KLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 376

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 377 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 429

[183][TOP]
>UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3173
          Length = 622

 Score =  132 bits (333), Expect = 1e-29
 Identities = 71/178 (39%), Positives = 103/178 (57%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + D +   +I  L+KCDF  I A     KAK +A K   +  E+   +EA  
Sbjct: 128 FFQDWRKEMTDEE-RSLIQELDKCDFGEIHAM---HKAKVEARKN-MSKEEKLVLKEANQ 182

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + + ++   L+D   E +GNF++EP  LF GRG+HP  GK+K+RIQPEDV +N   +   
Sbjct: 183 KILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGKLKKRIQPEDVIINCSNSRVD 242

Query: 362 PECPVP----GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            E  +P    GH W ++ H++ VTWLA W ++I G  KY+ L+A S  KG  D  K+E
Sbjct: 243 RESRIPVPPAGHRWKEVRHDNTVTWLASWTENIQGSIKYIMLNANSKLKGEKDWEKYE 300

[184][TOP]
>UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN
          Length = 765

 Score =  132 bits (333), Expect = 1e-29
 Identities = 63/174 (36%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 278 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 332

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 333 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445

[185][TOP]
>UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA
          Length = 829

 Score =  132 bits (333), Expect = 1e-29
 Identities = 68/175 (38%), Positives = 102/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D++  +  T    +IT+L KCDF+ +  +      K+++E +   T E K   +AE 
Sbjct: 334 FFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF-----KEQSEARKNMTKEEKLKIKAEN 387

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E + NFR+EP  LF GRGDHP  GK+K+RI PED+ +N   ++ 
Sbjct: 388 ERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDSK 447

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IP  P  GH W ++ H+  VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 448 IPVAPA-GHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 501

[186][TOP]
>UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN
          Length = 765

 Score =  132 bits (333), Expect = 1e-29
 Identities = 63/174 (36%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 278 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 332

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 333 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445

[187][TOP]
>UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE
          Length = 767

 Score =  132 bits (333), Expect = 1e-29
 Identities = 63/174 (36%), Positives = 106/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 280 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 334

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 335 KLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[188][TOP]
>UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A49
          Length = 692

 Score =  132 bits (332), Expect = 1e-29
 Identities = 70/181 (38%), Positives = 100/181 (55%), Gaps = 7/181 (3%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAE------RK 160
           FF D+R  + D +   +I  L KCDF  I A H    +A+K   K+ +          + 
Sbjct: 143 FFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAMHKAKVEARKNMTKEEKQVCNIHFIMLKN 201

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
             +EA  + V +F   L+D   E +GNF++EP  LF GRG+HP  G +K+RIQPED+ +N
Sbjct: 202 ALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQGMLKKRIQPEDIIIN 261

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
               A IP  P  GH W ++ H++ VTWL  W ++I G  KY+ L+A S  KG  D  K+
Sbjct: 262 CSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTENIQGSIKYIMLNANSKLKGEKDWEKY 320

Query: 521 E 523
           E
Sbjct: 321 E 321

[189][TOP]
>UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE
          Length = 592

 Score =  132 bits (332), Expect = 1e-29
 Identities = 71/175 (40%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  +   +  ++IT L+KCDF+ I  H  +     +AE +     E+K+ +E EA
Sbjct: 107 FFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE-----RAEARRTLPREQKQLKE-EA 159

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           E+++Q F   ++DG  E +GNF+ EP  LF GRGDHP  G +KRR+ PEDV +N   ++ 
Sbjct: 160 EKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSK 219

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ V WLA W + I   +KYV L+  S  KG  D  K+E
Sbjct: 220 IPE-PPAGHQWKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYE 273

[190][TOP]
>UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus
           RepID=UPI00006154BF
          Length = 769

 Score =  132 bits (331), Expect = 2e-29
 Identities = 63/174 (36%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 282 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQTEARKQ-MSKEEKLKIKEENE 336

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 337 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 396

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 397 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 449

[191][TOP]
>UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK
          Length = 766

 Score =  132 bits (331), Expect = 2e-29
 Identities = 65/175 (37%), Positives = 102/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +    ITSL KCDF+ +  +      K + E + Q + E K+  + E 
Sbjct: 279 FFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQTEARKQMSKEEKQKIKEEN 332

Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ +++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   ++ 
Sbjct: 333 ERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDSK 392

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 393 VPP-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 446

[192][TOP]
>UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE
          Length = 725

 Score =  132 bits (331), Expect = 2e-29
 Identities = 74/171 (43%), Positives = 100/171 (58%), Gaps = 5/171 (2%)
 Frame = +2

Query: 26  LADTKFAKVITSLEKCDFSRIEAHLEDEKA---KKKAEKKAQTTAERKEAREAEAERVRQ 196
           L  TKF      L+K DF++I  HLE ++     K  E+K Q   ER +       R   
Sbjct: 107 LMQTKFEGF--QLDKADFTKIREHLEQQRLLRLNKSDEQKKQEKLERDQ-------RELF 157

Query: 197 FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPV 376
           +  ALVDG  E VGN+ +E   LF GRG+HP  G +K RI PE++T+NL   AP+P+C +
Sbjct: 158 YGYALVDGCLERVGNYTLEQPTLFKGRGEHPKAGLLKARIFPEELTVNLSTQAPVPQCKL 217

Query: 377 PGHNWGKIIHNSCVTWLAGWKDSI--TGGYKYVWLSAESAFKGMSDHAKFE 523
           PGH+WGKI+H + VTWL  + DS      +KYV  +A S FK M+D  K+E
Sbjct: 218 PGHSWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYE 268

[193][TOP]
>UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus
           norvegicus RepID=UPI0001B7BF13
          Length = 760

 Score =  131 bits (330), Expect = 2e-29
 Identities = 63/174 (36%), Positives = 105/174 (60%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +    IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 278 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 332

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D  +E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 333 KLLKEYGFCVMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 392

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 393 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 445

[194][TOP]
>UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5FAF
          Length = 573

 Score =  131 bits (330), Expect = 2e-29
 Identities = 68/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+  + + 
Sbjct: 86  FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 139

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++ 
Sbjct: 140 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 199

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 200 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 253

[195][TOP]
>UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F97
          Length = 790

 Score =  131 bits (330), Expect = 2e-29
 Identities = 68/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+  + + 
Sbjct: 318 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 371

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++ 
Sbjct: 372 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 431

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 432 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 485

[196][TOP]
>UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F96
          Length = 767

 Score =  131 bits (330), Expect = 2e-29
 Identities = 68/175 (38%), Positives = 106/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+  + + 
Sbjct: 280 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 333

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++ 
Sbjct: 334 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 393

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 394 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[197][TOP]
>UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE
          Length = 469

 Score =  131 bits (330), Expect = 2e-29
 Identities = 67/174 (38%), Positives = 103/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KCDFS +  +    KA+ +A +KA T  E+ + +E   
Sbjct: 271 FFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKEENE 325

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++++   ++D  +E + NFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++  
Sbjct: 326 RILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKH 385

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 386 P-TPPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 438

[198][TOP]
>UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE
          Length = 758

 Score =  131 bits (330), Expect = 2e-29
 Identities = 67/174 (38%), Positives = 103/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KCDFS +  +    KA+ +A +KA T  E+ + +E   
Sbjct: 271 FFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKEENE 325

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++++   ++D  +E + NFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++  
Sbjct: 326 RILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKH 385

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 386 P-TPPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 438

[199][TOP]
>UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica
           RepID=UPI0000F2B3E5
          Length = 916

 Score =  131 bits (329), Expect = 3e-29
 Identities = 66/175 (37%), Positives = 103/175 (58%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +    IT+L KCDF++I  +      K ++E + Q + E K   + E 
Sbjct: 429 FFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF-----KAQSEARKQMSKEEKLKIKEEN 482

Query: 182 ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ +++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A 
Sbjct: 483 ERLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAK 542

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 543 VPP-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 596

[200][TOP]
>UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0
          Length = 758

 Score =  131 bits (329), Expect = 3e-29
 Identities = 63/174 (36%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +    IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 271 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 325

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 326 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 385

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 386 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 438

[201][TOP]
>UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA
          Length = 969

 Score =  131 bits (329), Expect = 3e-29
 Identities = 66/175 (37%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF D+R  +   +  + IT LEKC+F  + A+  +      AE+    + E K A +A  
Sbjct: 503  FFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEI-----AEQNRNRSKEEKAALKAAN 556

Query: 182  ERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
            E++ +++ + ++DG +E +GNF++EP  LF GRG+HP  G VKRR+ PEDV +N   ++ 
Sbjct: 557  EQLTKEYGICVIDGHKEKIGNFKIEPPGLFRGRGEHPKMGLVKRRVMPEDVIINCSQDSK 616

Query: 359  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            IP  P PG  W ++ H++ V+WLA W +++ G  KY+ L+  S  KG  D  K+E
Sbjct: 617  IPS-PPPGRRWKEVRHDNTVSWLASWVENVQGQVKYIMLNPSSKLKGEKDWQKYE 670

[202][TOP]
>UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT
          Length = 767

 Score =  131 bits (329), Expect = 3e-29
 Identities = 63/174 (36%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +    IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 280 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 334

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 335 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[203][TOP]
>UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE
          Length = 767

 Score =  131 bits (329), Expect = 3e-29
 Identities = 63/174 (36%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +    IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 280 FFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 334

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 335 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 394

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 395 PS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[204][TOP]
>UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU
          Length = 767

 Score =  130 bits (328), Expect = 4e-29
 Identities = 67/175 (38%), Positives = 105/175 (60%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   + +K IT L KC+F+ +  +      K ++E + Q + E K+  + + 
Sbjct: 280 FFKDWRKEMTSEEKSK-ITDLNKCNFAGMNDYF-----KAQSEARKQMSKEEKQKIKEDN 333

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           ER+ Q +   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI+PED+ +N   ++ 
Sbjct: 334 ERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSK 393

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 394 HPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 447

[205][TOP]
>UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A2H9_NITMS
          Length = 551

 Score =  130 bits (328), Expect = 4e-29
 Identities = 82/178 (46%), Positives = 103/178 (57%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK----KAEKKAQTTAERKEAR 169
           F ADF   L D+KF K+  S E  DFS     ++ EK  K    K EKKA   A+RKE R
Sbjct: 62  FTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEMMTKEEKKA-IAAKRKELR 117

Query: 170 EAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 349
           E   E   ++ VA++DG+E  VGN+  EP  +F+GRG+HPL G+ K R+  +DVTLNLG 
Sbjct: 118 E---ELKSKYGVAVMDGKEVEVGNYMAEPPGIFIGRGEHPLRGRWKPRVTAKDVTLNLGK 174

Query: 350 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            A +PE       WGKIIH+    WLA W D +T   KYVWLS  S  K   D  K+E
Sbjct: 175 EAKVPE-----GKWGKIIHDKDSMWLASWMDFLTQKRKYVWLSDSSDLKQGRDKEKYE 227

[206][TOP]
>UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE
          Length = 596

 Score =  130 bits (326), Expect = 7e-29
 Identities = 73/171 (42%), Positives = 101/171 (59%), Gaps = 5/171 (2%)
 Frame = +2

Query: 26  LADTKFAKVITSLEKCDFSRIEAHLEDEKA---KKKAEKKAQTTAERKEAREAEAERVRQ 196
           L  TKF      L+K DF++I+ +LE ++     K  E+K Q   ER +       R   
Sbjct: 107 LMQTKFEGF--QLDKADFTKIKEYLEQQRLLRLNKSDEQKKQEKLERDQ-------RELF 157

Query: 197 FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPV 376
           +  ALVDG  E VGN+ +E   LF GRG+HP  G +K RI PE++T+NL   AP+P+C +
Sbjct: 158 YGYALVDGCLERVGNYTLEQPTLFKGRGEHPKAGLLKARIFPEELTVNLSTQAPVPQCKL 217

Query: 377 PGHNWGKIIHNSCVTWLAGWKDSI--TGGYKYVWLSAESAFKGMSDHAKFE 523
           PGH+WGKI+H + VTWL  + DS      +KYV  +A S FK M+D  K+E
Sbjct: 218 PGHSWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYE 268

[207][TOP]
>UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE
          Length = 966

 Score =  129 bits (325), Expect = 9e-29
 Identities = 67/174 (38%), Positives = 99/174 (56%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +  ++  K I  L+KC+F  +  H  +     +   K Q  A  KE  EA  
Sbjct: 485 FFKDWRKSMTSSEREK-IKDLKKCNFRSMHKHFAEISEANRNRTKEQKLA-LKEQNEA-- 540

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             ++++    +DG +E +GNFR+EP  LF GRG+HP  G VKRR+ PEDV +N G  +  
Sbjct: 541 -LMKEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMVKRRVMPEDVIINCGKESVW 599

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P+ P  GH W ++ H++ V+WLA W +++ G  KYV L+  S  KG  D  K+E
Sbjct: 600 PKAP-EGHRWKEVRHDNSVSWLASWTENVQGQVKYVMLNPSSKLKGEKDWQKYE 652

[208][TOP]
>UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus
            familiaris RepID=UPI00005A45B7
          Length = 1004

 Score =  129 bits (324), Expect = 1e-28
 Identities = 62/174 (35%), Positives = 104/174 (59%)
 Frame = +2

Query: 2    FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
            FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 517  FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 571

Query: 182  ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
            + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 572  KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 631

Query: 362  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            P  P  GH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 632  PS-PPTGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 684

[209][TOP]
>UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1
           Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294
          Length = 786

 Score =  129 bits (324), Expect = 1e-28
 Identities = 67/176 (38%), Positives = 102/176 (57%), Gaps = 2/176 (1%)
 Frame = +2

Query: 2   FFADFRA-LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 178
           FF D++  + AD +   +IT+L KCDF+ +  +      K+++E +   T E K+  + E
Sbjct: 297 FFKDWKKEMTADER--NLITNLGKCDFNAMSQYF-----KEQSEARKNMTKEEKQKIKEE 349

Query: 179 AERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNA 355
            ER+ Q +   ++D   E + NFR+EP  LF GRGDHP  GK+K+RI PED+ +N   ++
Sbjct: 350 NERLLQEYGFCVMDNHRERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDS 409

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
             P  P  GH W ++ H+  VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 410 KYPVAPA-GHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 464

[210][TOP]
>UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30
          Length = 752

 Score =  129 bits (324), Expect = 1e-28
 Identities = 62/174 (35%), Positives = 104/174 (59%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  + + +   +IT+L KCDF+++  +    KA+ +A K+  +  E+ + +E   
Sbjct: 265 FFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KAQSEARKQ-MSKEEKLKIKEENE 319

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           + ++++   ++D   E + NF++EP  LF GRG+HP  G +KRRI PED+ +N   +A +
Sbjct: 320 KLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKV 379

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  GH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E
Sbjct: 380 PS-PPTGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE 432

[211][TOP]
>UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG
          Length = 806

 Score =  129 bits (324), Expect = 1e-28
 Identities = 72/193 (37%), Positives = 105/193 (54%), Gaps = 19/193 (9%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAE------RKE 163
           FF D+R  +   + AK IT L+KCDFS +  + + +   +KA  K +          R+ 
Sbjct: 246 FFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTEARKAMTKEEKLVSPHPHSCRRR 304

Query: 164 AREA------------EAERV-RQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKV 304
            R A            E ER+ +QF   ++D  +E + NFR+EP  LF GRGDHP  G +
Sbjct: 305 LRAAGFIPSAFQKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKMGML 364

Query: 305 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAE 484
           KRRI+PED+ +N   ++  PE P PG  W ++ H++ VTWL  W ++I G  KY+ L+  
Sbjct: 365 KRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPS 423

Query: 485 SAFKGMSDHAKFE 523
           S  KG  D  K+E
Sbjct: 424 SRIKGEKDWQKYE 436

[212][TOP]
>UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni
           RepID=C4Q6C8_SCHMA
          Length = 587

 Score =  129 bits (324), Expect = 1e-28
 Identities = 62/174 (35%), Positives = 101/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+   + + +  + I SL KCDF  +  +      K   E+K +T  E+++ +E   
Sbjct: 199 FFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEERKNRTKEEKQKIKEENL 253

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +   ++   ++DG ++ +GNFR+EP  LF GRG+HP  G +K+RI PEDV +N   ++ +
Sbjct: 254 QIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKV 313

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  GH W ++ H++ VTWLA W ++I   +KY+ L+  S  KG  D  K+E
Sbjct: 314 P-APPKGHKWKEVRHDNSVTWLACWTENIQNSFKYIMLNPSSRLKGEKDWKKYE 366

[213][TOP]
>UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni
           RepID=C4Q6C7_SCHMA
          Length = 652

 Score =  129 bits (324), Expect = 1e-28
 Identities = 62/174 (35%), Positives = 101/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+   + + +  + I SL KCDF  +  +      K   E+K +T  E+++ +E   
Sbjct: 199 FFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEERKNRTKEEKQKIKEENL 253

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +   ++   ++DG ++ +GNFR+EP  LF GRG+HP  G +K+RI PEDV +N   ++ +
Sbjct: 254 QIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKV 313

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  GH W ++ H++ VTWLA W ++I   +KY+ L+  S  KG  D  K+E
Sbjct: 314 P-APPKGHKWKEVRHDNSVTWLACWTENIQNSFKYIMLNPSSRLKGEKDWKKYE 366

[214][TOP]
>UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva
           RepID=Q4N5U3_THEPA
          Length = 1003

 Score =  129 bits (323), Expect = 2e-28
 Identities = 71/156 (45%), Positives = 96/156 (61%), Gaps = 3/156 (1%)
 Frame = +2

Query: 62  LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 241
           L   DFS I+ HLEDEK KKK  K+       K  ++ +A+R  +F  ALVD   E V +
Sbjct: 415 LTDVDFSLIKTHLEDEKQKKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSS 469

Query: 242 FRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNS 412
            ++EP  LF GRG HP  G +K R+ P+DV LNL  +AP+P+       GH+W  I H++
Sbjct: 470 NKLEPPGLFKGRGLHPKQGLLKARMFPKDVILNLSKDAPVPKVSNFQREGHSWKDIYHDN 529

Query: 413 CVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
            VTWLA +KDSI   +KY++LSA+S FKG  D  K+
Sbjct: 530 SVTWLAYYKDSINDQFKYMYLSAQSKFKGFHDFLKY 565

[215][TOP]
>UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7
          Length = 839

 Score =  127 bits (320), Expect = 4e-28
 Identities = 71/167 (42%), Positives = 101/167 (60%), Gaps = 3/167 (1%)
 Frame = +2

Query: 32  DTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVA 208
           +TK  K  I++ +  DF  I+ HL     K + EK  +T  E++E ++   E+   +T A
Sbjct: 234 ETKLKKGDISNFKFIDFMPIKDHL----LKLREEKLNKTKEEKEEEKKMRMEKELPYTYA 289

Query: 209 LVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPG 382
           LVD   E + + + EP  LF GRG+HP  G +K+RI PEDV +N+  +AP+P     + G
Sbjct: 290 LVDWIREKISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDNMCG 349

Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           HNWG I H++ VTWLA +KDSI    KY +LSA+S FKG  D  K+E
Sbjct: 350 HNWGDIYHDNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDLMKYE 396

[216][TOP]
>UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI
          Length = 638

 Score =  127 bits (320), Expect = 4e-28
 Identities = 69/174 (39%), Positives = 98/174 (56%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DFR L    +  K+I    KC+F  I    + E  K+ A  K +  A+RK+      
Sbjct: 141 FFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNKRLAATKEEKLAKRKKNEAF-- 197

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
             V ++   LVDG  E + NFR+EP  LF GRGDHP  G +KRR+Q  D+ +N G ++ I
Sbjct: 198 --VNKYGFCLVDGHRERISNFRLEPPGLFRGRGDHPKMGMIKRRVQACDIIINCGRDSKI 255

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           P  P  G  W ++ H++ VTWLA W D++ G  KY+ L++ S  +  SDH K+E
Sbjct: 256 P-MPPRGQMWKEVRHDNTVTWLASWVDNVQGQSKYIILNSWSKIRCESDHNKYE 308

[217][TOP]
>UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia
           guttata RepID=UPI000194BDF0
          Length = 662

 Score =  127 bits (319), Expect = 5e-28
 Identities = 64/175 (36%), Positives = 101/175 (57%), Gaps = 1/175 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+R  +   +  ++I  L+KCDF  I  +  ++   +K   K     E K+  + EA
Sbjct: 175 FFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEKNEARKGLPK-----EEKQKLKEEA 228

Query: 182 ERVRQ-FTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAP 358
           +++++ +   ++DG  E +GNF+ EP  LF GRG+HP  G +K+RI PEDV +N   ++ 
Sbjct: 229 DKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGEHPKMGMLKKRIMPEDVIINCSKDSK 288

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           IPE P  GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  K+E
Sbjct: 289 IPE-PPEGHKWKEVRFDNTVTWLASWTENIQNTLKYIMLNPSSKLKGEKDWEKYE 342

[218][TOP]
>UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata
           RepID=Q4UDP8_THEAN
          Length = 999

 Score =  127 bits (319), Expect = 5e-28
 Identities = 70/156 (44%), Positives = 96/156 (61%), Gaps = 3/156 (1%)
 Frame = +2

Query: 62  LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 241
           L   DFS I+ HLE+EK KKK  K+       K  ++ +A+R  +F  ALVD   E V +
Sbjct: 416 LSDADFSLIKNHLEEEKQKKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSS 470

Query: 242 FRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNS 412
            ++EP  LF GRG HP  G +K R+ P+DV LNL  +AP+P+       GH+W  I H++
Sbjct: 471 NKLEPPGLFKGRGLHPKQGLLKSRMFPKDVILNLSKDAPVPKVTNFQREGHSWKDIYHDN 530

Query: 413 CVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
            VTWLA +KDSI   +KY++LSA+S FKG  D  K+
Sbjct: 531 SVTWLAYYKDSINDQFKYMYLSAQSKFKGFHDFLKY 566

[219][TOP]
>UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1
           Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH
          Length = 713

 Score =  127 bits (319), Expect = 5e-28
 Identities = 69/173 (39%), Positives = 98/173 (56%), Gaps = 20/173 (11%)
 Frame = +2

Query: 65  EKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTV-ALVDGREETVGN 241
           +K DF+ I+ HLE++K  +K   K     E K   + + ER+  +   A++DG  E VG 
Sbjct: 213 DKFDFTPIKIHLEEQKEIRKNRSK-----EEKNQEKQKKERLSDYYAGAILDGFREKVGQ 267

Query: 242 FRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVP-------------- 379
           F +EP  LF GRG+HP  G +K RIQPE V +N+  +AP+P+C VP              
Sbjct: 268 FMIEPPTLFKGRGEHPKMGMMKGRIQPEAVVINISKDAPVPKCSVPDCIHICRQIFNEFP 327

Query: 380 ----GHNWGKIIHNSCVTWLAGWK-DSITGGYKYVWLSAESAFKGMSDHAKFE 523
               GH W +I+H   VTWLA +K DS+   +KY++LSAES  K  +D  K+E
Sbjct: 328 KKQLGHGWSEIVHKQDVTWLASYKDDSVKKQHKYIFLSAESKLKAENDKKKYE 380

[220][TOP]
>UniRef100_UPI000180B1AE PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Ciona
           intestinalis RepID=UPI000180B1AE
          Length = 482

 Score =  127 bits (318), Expect = 6e-28
 Identities = 60/157 (38%), Positives = 95/157 (60%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232
           IT L KC+F  + ++ +    +K  E+KA++  E++E ++     + +F     DG  E 
Sbjct: 10  ITDLGKCNFRDVCSYFQ----QKSEERKARSKEEKQEEKKKNEALIEEFGFCDWDGHREK 65

Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNS 412
           +GNFR+EP  LF GRG+HP  GK+K+RI PE++T+N   N+ IP+ P  GH W ++ H++
Sbjct: 66  IGNFRLEPPGLFRGRGNHPKMGKLKKRIIPENITINCSKNSKIPK-PPAGHKWKEVRHDN 124

Query: 413 CVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
            VTWL  W +++    KY+ L+  S  KG  D  K+E
Sbjct: 125 AVTWLVSWTENVQNQNKYIMLNPSSRVKGEKDWQKYE 161

[221][TOP]
>UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2BD10
          Length = 349

 Score =  127 bits (318), Expect = 6e-28
 Identities = 66/151 (43%), Positives = 93/151 (61%), Gaps = 1/151 (0%)
 Frame = +2

Query: 47  KVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGR 223
           K+IT+L KCDF+ I  +      +K  EKK  T    KE  + EA R+  +F   L+DG 
Sbjct: 208 KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----KEVLKDEAARLMEEFGYCLLDGH 259

Query: 224 EETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKII 403
            E +GNF++EP  LF GRG+HP  G++K+RIQPEDV +N   ++ IPE P  GH W ++ 
Sbjct: 260 REKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCSKDSKIPE-PPAGHKWKRVQ 318

Query: 404 HNSCVTWLAGWKDSITGGYKYVWLSAESAFK 496
           H++ VTWLA W ++I    KY+ L+  S  K
Sbjct: 319 HDNTVTWLASWLENIQKRPKYIMLNPSSKLK 349

[222][TOP]
>UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1
           Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO
          Length = 886

 Score =  126 bits (317), Expect = 8e-28
 Identities = 67/159 (42%), Positives = 96/159 (60%), Gaps = 2/159 (1%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232
           I++ +  DF  I+ HL     K + E+  +T  E++E ++   E+   +T ALVD   E 
Sbjct: 294 ISNFKFIDFMTIKEHL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREK 349

Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406
           + + + EP  LF GRG+HP  G +K+RI PEDV +N+  +AP P     + GHNWG I H
Sbjct: 350 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYH 409

Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA +KDSI    KY +LSA+S FKG  D  K+E
Sbjct: 410 DNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 448

[223][TOP]
>UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H
           RepID=B3L6G4_PLAKH
          Length = 924

 Score =  126 bits (317), Expect = 8e-28
 Identities = 67/159 (42%), Positives = 97/159 (61%), Gaps = 2/159 (1%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232
           I++ +  DF  I+ HL     K + EK  +T  E++E ++  +E+    T ALVD   E 
Sbjct: 276 ISNFQFIDFMPIKDHL----VKLREEKLNRTKEEKEEEKKLRSEKELPHTYALVDWIREK 331

Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406
           + + + EP  LF GRG+HP  G +K+RI PEDV +N+  +AP+P     + GH+WG I H
Sbjct: 332 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYGDMCGHSWGDIYH 391

Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA +KDSI    KY +LSA+S FKG  D  K+E
Sbjct: 392 DNKVTWLAYYKDSINDQLKYTFLSAQSKFKGYKDFLKYE 430

[224][TOP]
>UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F98
          Length = 790

 Score =  125 bits (315), Expect = 1e-27
 Identities = 67/189 (35%), Positives = 106/189 (56%), Gaps = 15/189 (7%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKKKAEKKA---------- 139
           FF D+R  +   + +K IT L KC+F+ +    +A  E  K   K EK+           
Sbjct: 253 FFKDWRKEMTSEEKSK-ITDLNKCNFAGMNEYFKAQSEARKQMSKEEKQVSLHSITCSPA 311

Query: 140 -QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRI 316
            +T++   + +E     ++++   ++D  +E +GNFR+EP  LF GRGDHP  G +KRRI
Sbjct: 312 LKTSSHLNKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPKMGMLKRRI 371

Query: 317 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFK 496
           +PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  K
Sbjct: 372 RPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIK 430

Query: 497 GMSDHAKFE 523
           G  D  K+E
Sbjct: 431 GEKDWQKYE 439

[225][TOP]
>UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi
           RepID=Q4XMK5_PLACH
          Length = 429

 Score =  125 bits (315), Expect = 1e-27
 Identities = 67/159 (42%), Positives = 96/159 (60%), Gaps = 2/159 (1%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232
           I++ +  DF  I+ HL     K + E+  +T  E++E ++   E+   +T ALVD   E 
Sbjct: 269 ISNFKFIDFMTIKEHL----IKLRDERLNKTKEEKEEDKKIRMEKELPYTFALVDWIREK 324

Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406
           + + + EP  LF GRG+HP  G +K+RI PEDV +N+  +AP P     + GHNWG I H
Sbjct: 325 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYH 384

Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA +KDSI    KY +LSA+S FKG  D  K+E
Sbjct: 385 DNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 423

[226][TOP]
>UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO
          Length = 701

 Score =  124 bits (312), Expect = 3e-27
 Identities = 66/157 (42%), Positives = 94/157 (59%), Gaps = 3/157 (1%)
 Frame = +2

Query: 59  SLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVG 238
           +L+ CDFS I AHL+ E+ KKK +K+       K  +E  A++   +  ALVD   E VG
Sbjct: 195 TLKDCDFSEIRAHLDMEREKKKEQKEYY-----KALKEETAKKEHPYCYALVDWIREKVG 249

Query: 239 NFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPV---PGHNWGKIIHN 409
           + R+EP  LF GRG HP  G +K R  P  V LNL  +AP+P+  +    GH W  I H+
Sbjct: 250 SNRMEPPGLFKGRGLHPKQGLLKGRTFPHSVVLNLSKDAPVPKVSMFERQGHGWSDIFHD 309

Query: 410 SCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
           S VTWLA ++D++    KY++ +A+S FKG+ D  K+
Sbjct: 310 SSVTWLAYYRDTVNDQTKYMYPAAQSKFKGLHDFLKY 346

[227][TOP]
>UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax
           RepID=A5KB33_PLAVI
          Length = 931

 Score =  124 bits (311), Expect = 4e-27
 Identities = 66/159 (41%), Positives = 96/159 (60%), Gaps = 2/159 (1%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232
           I++ +  DF  I+ HL     K + EK  +T  E++E ++  +E+   +T ALVD   E 
Sbjct: 276 ISNFKFIDFMPIKDHL----VKLREEKLNRTKEEKEEEKKLRSEKELPYTYALVDWIREK 331

Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406
           + + + EP  LF GRG+HP  G +K+RI PEDV +N+  +AP+P     + GH WG   H
Sbjct: 332 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDDMCGHCWGDTYH 391

Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA +KDSI    KY +LSA+S FKG  D  K+E
Sbjct: 392 DNKVTWLAYYKDSINDQLKYTFLSAQSKFKGYKDFLKYE 430

[228][TOP]
>UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei
           RepID=Q4YYG2_PLABE
          Length = 805

 Score =  124 bits (310), Expect = 5e-27
 Identities = 66/159 (41%), Positives = 96/159 (60%), Gaps = 2/159 (1%)
 Frame = +2

Query: 53  ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 232
           I++ +  DF  I+ +L     K + E+  +T  E++E ++   E+   +T ALVD   E 
Sbjct: 239 ISNFKFIDFMTIKENL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREK 294

Query: 233 VGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIH 406
           + + + EP  LF GRG+HP  G +K+RI PEDV +N+  +AP P     + GHNWG I H
Sbjct: 295 ISSNKAEPPGLFRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYH 354

Query: 407 NSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           ++ VTWLA +KDSI    KY +LSA+S FKG  D  K+E
Sbjct: 355 DNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 393

[229][TOP]
>UniRef100_UPI0000E48333 PREDICTED: similar to topoisomerase I alpha isoform 3, partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48333
          Length = 440

 Score =  116 bits (291), Expect = 8e-25
 Identities = 55/121 (45%), Positives = 75/121 (61%)
 Frame = +2

Query: 161 EAREAEAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLN 340
           E +    E  +++     DG +E +GNFRVEP +LF GRG+HP  G++K+RI PEDV +N
Sbjct: 1   ENKRKNEEIQKEYGFCSFDGHKEKIGNFRVEPPSLFRGRGEHPKQGQLKKRIGPEDVIIN 60

Query: 341 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKF 520
              ++  P  P  GH W K+IH + VTWLA W ++I G  KYV L+  S  KG  D AK+
Sbjct: 61  CSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQGAIKYVMLNPSSRIKGEKDWAKY 119

Query: 521 E 523
           E
Sbjct: 120 E 120

[230][TOP]
>UniRef100_B3T4E9 Putative eukaryotic DNA topoisomerase I, catalytic core n=1
           Tax=uncultured marine crenarchaeote HF4000_ANIW133O4
           RepID=B3T4E9_9ARCH
          Length = 563

 Score =  116 bits (291), Expect = 8e-25
 Identities = 61/167 (36%), Positives = 92/167 (55%), Gaps = 6/167 (3%)
 Frame = +2

Query: 41  FAKVITS-LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVA--- 208
           FAK      +   +S I+  L  +   K+ E+K   T E K+A   + + +R+   A   
Sbjct: 73  FAKTFNGKFKNLQYSDIDFSLAHQLVDKEKEEKELLTKEDKKALAIKRKEIREEMKAKYG 132

Query: 209 --LVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382
             ++DG+E  +GN+  EP  +F+GRG+HP+ G+ K R+  +DVTLNLG  A IPE     
Sbjct: 133 NGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLNLGKEAKIPEA---- 188

Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
             WGKI+H+    W+A W D +T   KYVWL+  +  K   D AK++
Sbjct: 189 -KWGKIVHDRNSMWIASWMDILTQKRKYVWLADTAGIKQEMDQAKYD 234

[231][TOP]
>UniRef100_B3TAG0 Putative eukaryotic DNA topoisomerase I, catalytic core n=1
           Tax=uncultured marine crenarchaeote HF4000_APKG8D22
           RepID=B3TAG0_9ARCH
          Length = 563

 Score =  115 bits (289), Expect = 1e-24
 Identities = 61/167 (36%), Positives = 92/167 (55%), Gaps = 6/167 (3%)
 Frame = +2

Query: 41  FAKVITS-LEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVA--- 208
           FAK      +   +S I+  L  +   K+ E+K   T E K+A   + + +R+   A   
Sbjct: 73  FAKTFNGKFKNLQYSDIDFSLAYQLVDKEKEEKELLTKEDKKALAIKRKEIREEMKAKYG 132

Query: 209 --LVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPG 382
             ++DG+E  +GN+  EP  +F+GRG+HP+ G+ K R+  +DVTLNLG  A IPE     
Sbjct: 133 NGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLNLGKEAKIPEA---- 188

Query: 383 HNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
             WGKI+H+    W+A W D +T   KYVWL+  +  K   D AK++
Sbjct: 189 -KWGKIVHDRNSMWIASWMDILTQKRKYVWLADTAGIKQEMDQAKYD 234

[232][TOP]
>UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)
           (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD
          Length = 620

 Score =  114 bits (284), Expect = 5e-24
 Identities = 61/174 (35%), Positives = 101/174 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF+D+R  +   +  +VI  L++CDF+ I  H  D    K A +KA +  E+++ +E E 
Sbjct: 70  FFSDWRKEMTAEE-GRVIKHLDRCDFTEIHRHSVD----KTASQKALSREEKQKLKEEEE 124

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +  ++F  +++DG  E +G+F+ EP ++  GRGDHP   ++KRR+ PEDV +N   ++ +
Sbjct: 125 KLQQEFGCSILDGHREKIGSFKTEPWSV-RGRGDHPKMERLKRRVLPEDVVINCSRDSTV 183

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           PE P  G  W ++  +  V WLA W +++    KYV L+     KG  D  K+E
Sbjct: 184 PE-PPAGPQWKEVGCDCTVMWLAAWTENVQNFIKYVTLNPGCKLKGERDWGKYE 236

[233][TOP]
>UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum
           RepID=A0RU10_CENSY
          Length = 519

 Score =  110 bits (276), Expect = 5e-23
 Identities = 61/153 (39%), Positives = 87/153 (56%), Gaps = 3/153 (1%)
 Frame = +2

Query: 74  DFSRIEAHLEDEKAKKKA---EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNF 244
           DFS     ++ EK KK     E+K +  A+RKE RE    +   + +A++DG+E  + ++
Sbjct: 80  DFSEAYRLVDMEKDKKDMMTKEEKKEIAAKRKEIREGLKAK---YGIAVMDGKEVEIASY 136

Query: 245 RVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTW 424
             EP  +F+GRG HPL GK KRRI P+DV LN+G  A  P    PG  W KI+H     W
Sbjct: 137 MAEPPGIFIGRGKHPLRGKWKRRIGPQDVVLNMGTKAKAP----PG-KWKKIVHEKDGIW 191

Query: 425 LAGWKDSITGGYKYVWLSAESAFKGMSDHAKFE 523
           +A W D++    KYVWL+  +  K   D +K+E
Sbjct: 192 IAKWTDNLVKKDKYVWLADTAGLKQERDRSKYE 224

[234][TOP]
>UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA
          Length = 790

 Score =  108 bits (271), Expect = 2e-22
 Identities = 68/178 (38%), Positives = 102/178 (57%), Gaps = 4/178 (2%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           F +D+R +L +     +I +LE CDF+ I    + EK KKK      +T E+K  +E + 
Sbjct: 276 FMSDWRKILGEKH---IIQNLEDCDFTPIYEWHQREKEKKKQ----MSTDEKKAIKEGKD 328

Query: 182 E-RVRQFTVALVDGRE-ETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPE-DVTLNLGPN 352
           E R  ++  A+VDG   E VGNFRV  + +           +VK+ +  + D+T+N+G +
Sbjct: 329 ETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWRASKDPQVKKNVYSQIDITINIGKD 388

Query: 353 APIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAESAFKGMSDHAKFE 523
           APIPE P+PG  W +I H++ VTWLA W D I    +KYV+L+A S+ KG     K+E
Sbjct: 389 APIPEPPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGKVTREKYE 446

[235][TOP]
>UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5C1T3_SCHJA
          Length = 330

 Score =  108 bits (270), Expect = 2e-22
 Identities = 52/145 (35%), Positives = 85/145 (58%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF D+   + + +  + I SL KCDF  +  +      K   E+K +T  E+++ +E   
Sbjct: 191 FFHDWVKTMNEEE-RRTIKSLSKCDFQEMHQYF----LKLSEERKNRTKEEKQKIKEENL 245

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
           +   ++   ++DG ++ +GNFR+EP  LF GRG+HP  G +K+RI PEDV +N   ++ +
Sbjct: 246 QIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKMGMLKKRIMPEDVIINCSKDSKV 305

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGW 436
           P  P  GH W ++ H++ VTWLA W
Sbjct: 306 P-APPKGHKWKEVRHDNSVTWLACW 329

[236][TOP]
>UniRef100_Q56XA9 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana
           RepID=Q56XA9_ARATH
          Length = 396

 Score = 88.2 bits (217), Expect = 3e-16
 Identities = 39/77 (50%), Positives = 55/77 (71%), Gaps = 1/77 (1%)
 Frame = +2

Query: 296 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVW 472
           G++K+RI P ++TLN+G  APIPECP+ G  W ++ H++ VTWLA W D I    +KYV+
Sbjct: 1   GELKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVF 60

Query: 473 LSAESAFKGMSDHAKFE 523
           L A S+ KG+SD  K+E
Sbjct: 61  LGAGSSLKGLSDKEKYE 77

[237][TOP]
>UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI
          Length = 557

 Score = 86.3 bits (212), Expect = 1e-15
 Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 2/158 (1%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR-EAE 178
           FF DFR+ L+  +     TS + C+F +I  +LE                E++EAR + E
Sbjct: 129 FFKDFRSCLSVEQRLH-FTSFDLCNFQKIHQYLE----------------EQQEARSQQE 171

Query: 179 AERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLT-GKVKRRIQPEDVTLNLGPNA 355
            E   ++    +DG    +  FR++P  L   R  + LT G ++ R+ PED+ +N    A
Sbjct: 172 LEEDERYGYCYIDGERHRINQFRIKPPGLCCPRKGYSLTMGMIRPRVLPEDIMINCDEYA 231

Query: 356 PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYV 469
             P  P PGH W +++H+  V+WL  W D ++G   YV
Sbjct: 232 E-PPAPPPGHRWRQVVHDRSVSWLYSWHDLVSGNTYYV 268

[238][TOP]
>UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187E0BD
          Length = 265

 Score = 84.7 bits (208), Expect = 3e-15
 Identities = 48/116 (41%), Positives = 67/116 (57%), Gaps = 2/116 (1%)
 Frame = +2

Query: 2   FFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 175
           FF D+  +L D   +    +T  +KCDF  +  + E EKAKKKA     + AE+KE ++ 
Sbjct: 145 FFEDWLKVLQDHPPRNGIKVTDFDKCDFRPMYEYFEAEKAKKKA----MSAAEKKEIKKQ 200

Query: 176 EAERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNL 343
           + E   ++T   +DGR+E VGNFRVEP  LF GRG+HP  G +K    P  + L L
Sbjct: 201 KDEAEAKYTHCFLDGRKEKVGNFRVEPPGLFRGRGEHPKKGSLKVIGSPSLIALGL 256

[239][TOP]
>UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO
          Length = 555

 Score = 77.8 bits (190), Expect = 4e-13
 Identities = 48/164 (29%), Positives = 76/164 (46%), Gaps = 1/164 (0%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF +FR+ L++ +  + IT  E C+F  I  +LE                +R++ +E  A
Sbjct: 126 FFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLE---------------CQREDEKERIA 169

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLT-GKVKRRIQPEDVTLNLGPNAP 358
           E  + +   LVDG    +  FR+    L   R     T G ++ R+ PEDV +N   N  
Sbjct: 170 EENKLYGYCLVDGESRRITQFRISRPGLCCPRHGFSTTMGTIRPRVLPEDVVINCDENEE 229

Query: 359 IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAESA 490
            P  P  GH W  ++H+  V W+  W D +TG   + +   ES+
Sbjct: 230 -PPAPPCGHLWAAVVHDRTVRWVYAWNDIVTGCMHHAYPRNESS 272

[240][TOP]
>UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7
          Length = 879

 Score = 73.9 bits (180), Expect = 6e-12
 Identities = 35/73 (47%), Positives = 45/73 (61%)
 Frame = +2

Query: 305 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAE 484
           K+RI PEDV +N   ++  P  P  GH W K+IH + VTWLA W ++I G  KYV L+  
Sbjct: 488 KQRIGPEDVIINCSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQGAIKYVMLNPS 546

Query: 485 SAFKGMSDHAKFE 523
           S  KG  D AK+E
Sbjct: 547 SRIKGEKDWAKYE 559

[241][TOP]
>UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN
          Length = 240

 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 48/155 (30%), Positives = 74/155 (47%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF DF++ L+     + I S E CDF++I  +++ ++     ++K  T   R        
Sbjct: 80  FFKDFQSHLSRA-LRRQILSFELCDFTKIAFYIQGQQG---VQRKLMTPMMRNH------ 129

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPI 361
                +    +DG+   V +F  +  +L+   G  P  G VK RIQPEDV +N   N   
Sbjct: 130 -----YGYCTIDGKRHRVPHFSFDGPSLYRRSG--PKYGMVKPRIQPEDVNINSQENGA- 181

Query: 362 PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKY 466
           P  P  GH W  +IH+  V WL  W D+++G   Y
Sbjct: 182 PGAP-DGHTWKSVIHDRRVDWLWSWTDALSGRVHY 215

[242][TOP]
>UniRef100_B4E061 cDNA FLJ51170, highly similar to DNA topoisomerase I, mitochondrial
           (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4E061_HUMAN
          Length = 477

 Score = 69.3 bits (168), Expect = 2e-10
 Identities = 34/76 (44%), Positives = 46/76 (60%)
 Frame = +2

Query: 296 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWL 475
           G +KRRI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +SI    KY+ L
Sbjct: 2   GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESIQNSIKYIML 60

Query: 476 SAESAFKGMSDHAKFE 523
           +  S  KG +   KFE
Sbjct: 61  NPCSKLKGETAWQKFE 76

[243][TOP]
>UniRef100_UPI0001AE6F94 UPI0001AE6F94 related cluster n=1 Tax=Homo sapiens
           RepID=UPI0001AE6F94
          Length = 477

 Score = 68.9 bits (167), Expect = 2e-10
 Identities = 33/76 (43%), Positives = 46/76 (60%)
 Frame = +2

Query: 296 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWL 475
           G +KRRI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +S+    KY+ L
Sbjct: 2   GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIML 60

Query: 476 SAESAFKGMSDHAKFE 523
           +  S  KG +   KFE
Sbjct: 61  NPCSKLKGETAWQKFE 76

[244][TOP]
>UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major
           RepID=Q7YXA0_LEIMA
          Length = 200

 Score = 67.0 bits (162), Expect = 7e-10
 Identities = 45/102 (44%), Positives = 55/102 (53%)
 Frame = +2

Query: 2   FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 181
           FF  +R +L   K    I  LE CDF  I      ++ KK +  K +  A  KE ++AEA
Sbjct: 105 FFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQREKKLSRTKEEKEAI-KEKQDAEA 161

Query: 182 ERVRQFTVALVDGREETVGNFRVEPSNLFLGRGDHPLTGKVK 307
           E  R     + DGR E V NFRVEP  LF GRG HPL GK+K
Sbjct: 162 EPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLK 200