AU196570 ( PFL091d10_r )

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[1][TOP]
>UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum
           RepID=TOP1_DICDI
          Length = 893

 Score =  178 bits (452), Expect = 2e-43
 Identities = 83/174 (47%), Positives = 119/174 (68%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA+ L+TDHV K+ F+ NFF +F+ LL   +  +++  ++KCDFS I  HL+ +K 
Sbjct: 349 VATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKE 407

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           ++KA  K     E K+A  AE +++++    A +DG +E VGN+ +EPP LFLGRG HP 
Sbjct: 408 QRKARSK-----EEKDAETAEKKKIQEKHGFATIDGFKEKVGNYMIEPPGLFLGRGQHPK 462

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           TG +K+RI P DVTLN+G    IP  P+PG  W +I+HN+ VTWLA W++S+ G
Sbjct: 463 TGMLKQRIMPSDVTLNIGEGEVIPPSPIPGEKWKEIVHNNTVTWLAFWRESVNG 516

[2][TOP]
>UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO
          Length = 910

 Score =  171 bits (433), Expect = 3e-41
 Identities = 84/171 (49%), Positives = 115/171 (67%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A  L TD++ K +F+ NFF D++ +L       VI +LE CDFS I    + EK 
Sbjct: 403 VATMFAVMLDTDYMNKPRFKENFFGDWKKILGKNH---VIQNLENCDFSPIYEWHQSEKE 459

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      TT E+K  +E + ++  ++  A VDG++E VGNFRVEPP LF GRG+HP  
Sbjct: 460 KKKQ----MTTEEKKALKEEKLKQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKM 515

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RI+P D+T+N+G +APIPECPVPG  W ++ H++ VTWLA W D I
Sbjct: 516 GKLKKRIRPCDITINIGKDAPIPECPVPGERWKEVRHDNTVTWLAFWNDPI 566

[3][TOP]
>UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence
           n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI
          Length = 857

 Score =  169 bits (429), Expect = 8e-41
 Identities = 83/171 (48%), Positives = 114/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A  L TD++ KEKF+ NF AD+R +L       VI  L+ CDF+ I    ++EK 
Sbjct: 353 VATMFAVMLDTDYMQKEKFKENFMADWRKILGKNH---VIQRLDDCDFTPIYEWHQEEKE 409

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      +T E+K  +E + +   ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 410 KKKQ----MSTEEKKTLKEEKLKLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 465

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+KRRI P D+T+N+G N+ IPECP+PG +W ++ H++ VTWLA W D I
Sbjct: 466 GKLKRRIHPSDITINIGKNSQIPECPIPGESWKEVKHDNTVTWLAFWNDPI 516

[4][TOP]
>UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum
           bicolor RepID=C5YGY1_SORBI
          Length = 921

 Score =  167 bits (422), Expect = 5e-40
 Identities = 84/173 (48%), Positives = 113/173 (65%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A    TD+  K  F  NFF D+R +L       +I   E CDF+ I E HL    
Sbjct: 416 VATMFAVMKDTDYAGKPTFIDNFFTDWRKILGKNH---IIKKFELCDFTPIYEWHL---- 468

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            ++K +KK  TT E+K  RE + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP 
Sbjct: 469 -REKEKKKQMTTEEKKALREEKLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPK 527

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
            GK+KRRIQP D+T+N+G  AP+PECP+PG +W +I H++ VTWLA W D I+
Sbjct: 528 MGKLKRRIQPSDITINIGKGAPVPECPIPGESWKEIKHDNTVTWLAFWNDPIS 580

[5][TOP]
>UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis
           RepID=B9SSQ1_RICCO
          Length = 891

 Score =  166 bits (420), Expect = 9e-40
 Identities = 84/171 (49%), Positives = 112/171 (65%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A    TD++ K KF  NF+ D+R LL       VI  LE CDF+ I    E EK 
Sbjct: 385 VATMFAVMKDTDYMQKPKFLENFWNDWRKLLGRNH---VIQKLEDCDFTPIYEWHEREKE 441

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      +T E+K  +E +  +  ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 442 KKKQ----MSTEEKKAQKEEKLRQEEKYMWAIVDGVKEKVGNFRVEPPALFRGRGEHPKM 497

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RIQP D+T+N+G +APIPECP+PG +W ++ H++ VTWLA W D I
Sbjct: 498 GKLKKRIQPSDITINIGKDAPIPECPIPGESWKEVKHDNTVTWLAFWNDPI 548

[6][TOP]
>UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT
          Length = 926

 Score =  166 bits (420), Expect = 9e-40
 Identities = 79/171 (46%), Positives = 113/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A+ L TD++ K +F+ NFF+D++ +L        I +LE CDF  I    + EK 
Sbjct: 420 VATMFAAMLDTDYMNKPRFKENFFSDWKKILGKNH---TIQNLEDCDFGPIYEWHQQEKE 476

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      TT E+K  +E   +   ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 477 KKKQ----MTTEEKKALKEERLQLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKV 532

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RI+P D+T+N+G +APIPECP+PG  W ++ +++ VTWLA W D +
Sbjct: 533 GKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPV 583

[7][TOP]
>UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC
          Length = 852

 Score =  165 bits (418), Expect = 2e-39
 Identities = 81/171 (47%), Positives = 111/171 (64%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT YA  L TD++ K +F+ NF  D+R +L       VI +L+ CDF+ I      EK 
Sbjct: 372 VATMYAVMLDTDYMSKLQFKENFMNDWRKILGKNH---VIQNLDDCDFTPIYERPSSEKE 428

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      +T  ++  RE + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 429 KKKQ----MSTKRKRPLREEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 484

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+KRRI+P D+T+N+G  APIPECP+PG  W ++ H++ VTWLA W D I
Sbjct: 485 GKLKRRIRPNDITINIGKGAPIPECPIPGERWKEVRHDNTVTWLAFWNDPI 535

[8][TOP]
>UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group
           RepID=Q84ZL5_ORYSJ
          Length = 916

 Score =  165 bits (418), Expect = 2e-39
 Identities = 82/173 (47%), Positives = 114/173 (65%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A    TD+  K+ F  NFF D+R +L       VI   E CDF+ I E HL    
Sbjct: 411 VATMFAVMKDTDYASKQTFIDNFFTDWRKILGKNH---VIKKFELCDFTPIYEWHL---- 463

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            ++K +KK  T+ E+K  +E + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP 
Sbjct: 464 -REKEKKKQMTSEEKKALKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPK 522

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
            GK+KRRI+P D+T+N+G  APIPECP+PG +W ++ H++ VTWLA W D I+
Sbjct: 523 MGKLKRRIKPSDITINIGKGAPIPECPIPGESWKEVKHDNTVTWLAFWNDPIS 575

[9][TOP]
>UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT
          Length = 926

 Score =  165 bits (418), Expect = 2e-39
 Identities = 78/171 (45%), Positives = 113/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A  L TD++ K +F+ NFF+D++ +L        + +LE CDF  I    + EK 
Sbjct: 420 VATMFAVMLDTDYMTKPRFKENFFSDWKKMLGKNH---TVQNLEDCDFGPIYEWHQQEKE 476

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K+K      TT E+K  +E   ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 477 KRKQ----MTTEEKKALKEERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 532

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RI+P D+T+N+G +APIPECP+PG  W ++ +++ VTWLA W D I
Sbjct: 533 GKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWNDPI 583

[10][TOP]
>UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group
           RepID=A2YRB7_ORYSI
          Length = 916

 Score =  165 bits (418), Expect = 2e-39
 Identities = 82/173 (47%), Positives = 114/173 (65%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A    TD+  K+ F  NFF D+R +L       VI   E CDF+ I E HL    
Sbjct: 411 VATMFAVMKDTDYASKQTFIDNFFTDWRKILGKNH---VIKKFELCDFTPIYEWHL---- 463

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            ++K +KK  T+ E+K  +E + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP 
Sbjct: 464 -REKEKKKQMTSEEKKALKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPK 522

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
            GK+KRRI+P D+T+N+G  APIPECP+PG +W ++ H++ VTWLA W D I+
Sbjct: 523 MGKLKRRIKPSDITINIGKGAPIPECPIPGESWKEVKHDNTVTWLAFWNDPIS 575

[11][TOP]
>UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT
          Length = 927

 Score =  165 bits (417), Expect = 2e-39
 Identities = 80/171 (46%), Positives = 114/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A  L TD++ K +F+ NFF+D++ +L        I +LE CDF  I    + EK 
Sbjct: 421 VATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNH---TIQNLEDCDFGPIYEWHQQEKE 477

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      TT E+K  +E + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 478 KKKQ----MTTEEKKALKEDKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 533

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RI+P D+T+N+G +APIPECP+PG  W ++ +++ VTWLA W D I
Sbjct: 534 GKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWIDPI 584

[12][TOP]
>UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI
          Length = 760

 Score =  164 bits (415), Expect = 3e-39
 Identities = 84/179 (46%), Positives = 118/179 (65%), Gaps = 8/179 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEA 159
           VA F+ + L+TDH     F+ NFF DF+A+L ++  AK        I +  KCDFS + A
Sbjct: 174 VAGFFGAMLETDHAKNPTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDMYA 233

Query: 160 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFL 336
           H E    K + EKKA + AE+K A +AE +++ + F V L++GR+E VGNFR+EPP LF 
Sbjct: 234 HFE----KMREEKKAMSAAEKK-AIKAERDKIEEPFKVCLLNGRKEQVGNFRIEPPGLFR 288

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GRG HP TGK+KRR+ PE +T+N+G   P+PE P  GH WG++ H++ V WLA W ++I
Sbjct: 289 GRGAHPKTGKLKRRVMPEQITINIGKGVPVPE-PPAGHKWGEVRHDNSVAWLAMWHENI 346

[13][TOP]
>UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B7ZWU7_MAIZE
          Length = 574

 Score =  164 bits (414), Expect = 4e-39
 Identities = 82/172 (47%), Positives = 111/172 (64%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A    TD+  K  F  NFF D+R +L       +I + E CDF+ I E HL    
Sbjct: 69  VATMFAVMKDTDYAAKPTFIDNFFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL---- 121

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            ++K  KK  TT E+K  RE + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP 
Sbjct: 122 -REKERKKQMTTEEKKTLREDKLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPK 180

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            GK+KRRI P D+T+N+G  AP+PECP+PG +W ++ H++ VTWLA W D I
Sbjct: 181 MGKLKRRILPSDITINIGKGAPVPECPIPGESWKEVKHDNTVTWLAFWNDPI 232

[14][TOP]
>UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE
          Length = 904

 Score =  163 bits (413), Expect = 6e-39
 Identities = 82/172 (47%), Positives = 110/172 (63%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A    TD+  K  F  NFF D+R +L       +I + E CDF+ I E HL    
Sbjct: 399 VATMFAVMKDTDYAAKPTFIDNFFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL---- 451

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            ++K  KK  TT E+K  RE   ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP 
Sbjct: 452 -REKERKKQMTTEEKKTLREDNLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPK 510

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            GK+KRRI P D+T+N+G  AP+PECP+PG +W ++ H++ VTWLA W D I
Sbjct: 511 MGKLKRRILPSDITINIGKGAPVPECPIPGESWKEVKHDNTVTWLAFWNDPI 562

[15][TOP]
>UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC
          Length = 894

 Score =  163 bits (413), Expect = 6e-39
 Identities = 81/171 (47%), Positives = 113/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A  L TD++ K KF+ NF  D+R +L       VI +LE CDF+ I    + EK 
Sbjct: 389 VATMFAVMLDTDYMTKSKFKENFMDDWRKILGKNH---VIQNLEDCDFTPIYEWHQREKE 445

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      T  E+K  +E   ++  ++  A+V+G +E VGNFRVEPP+LF GRG+HP  
Sbjct: 446 KKKK----MTAEEKKVLKEERLKQEEKYMWAIVNGVKEKVGNFRVEPPSLFRGRGEHPKM 501

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+ I+P D+T+N+G +APIPECP+PG +W +I H++ VTWLA W D I
Sbjct: 502 GKLKKCIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAFWNDPI 552

[16][TOP]
>UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR
          Length = 877

 Score =  163 bits (412), Expect = 7e-39
 Identities = 81/171 (47%), Positives = 112/171 (65%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A    TD+V K +FR NF+ D+R LL       VI  L+ CDF+ I    + EK 
Sbjct: 372 VATMFAVMKDTDYVQKPQFRQNFWNDWRKLLGKNH---VIQKLDDCDFNPIYEWHQQEKE 428

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      +T E+K  +E + ++  ++  A+V+G +E VGNFRVEPP LF GRG+HP  
Sbjct: 429 KKKQ----MSTEEKKVLKEEKLKQEEKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKM 484

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K RI+P D+T+N+G +APIPECP+PG  W ++ H++ VTWLA W D I
Sbjct: 485 GKLKSRIRPSDITINIGKDAPIPECPIPGERWKEVKHDNTVTWLAFWNDPI 535

[17][TOP]
>UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5LJG7_9ALVE
          Length = 551

 Score =  163 bits (412), Expect = 7e-39
 Identities = 85/171 (49%), Positives = 113/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L TD   KEKF++NF+ADF+A L     +K IT L+ CDF  I+ +L+    
Sbjct: 133 VATFFAQTLGTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD---- 187

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K+   KKA+T  E++  +EA+      +T  +VD   E VGNFRVEPPNLF GRGDHP  
Sbjct: 188 KRSEAKKARTKEEKEAEKEAKRLNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKM 247

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+ I PEDVT+N   +AP P CPVPGH +  ++H+  VTWLA + D+I
Sbjct: 248 GKLKQYILPEDVTVNCAADAPAPRCPVPGHAYKDVVHDPAVTWLAWFTDTI 298

[18][TOP]
>UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5L755_9ALVE
          Length = 647

 Score =  163 bits (412), Expect = 7e-39
 Identities = 85/171 (49%), Positives = 113/171 (66%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L TD   KEKF++NF+ADF+A L     +K IT L+ CDF  I+ +L+    
Sbjct: 133 VATFFAQTLGTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD---- 187

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K+   KKA+T  E++  +EA+      +T  +VD   E VGNFRVEPPNLF GRGDHP  
Sbjct: 188 KRSEAKKARTKEEKEAEKEAKRLNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKM 247

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+ I PEDVT+N   +AP P CPVPGH +  ++H+  VTWLA + D+I
Sbjct: 248 GKLKQYILPEDVTVNCAADAPAPRCPVPGHAYKDVVHDPAVTWLAWFTDTI 298

[19][TOP]
>UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe
           RepID=TOP1_SCHPO
          Length = 814

 Score =  162 bits (411), Expect = 1e-38
 Identities = 74/171 (43%), Positives = 109/171 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA+ L+TDH     F+ NFF DF  +  +  F   I    KCDF+++  H E    
Sbjct: 234 VAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFE---- 289

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           +K+ EKK+    ++K  ++ + E   ++   ++DGR+E VGNFR+EPP LF GRG HP T
Sbjct: 290 QKREEKKSMPKEQKKAIKQKKDEEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHPKT 349

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +KRR+ PE +T+N+G   P+PE P+PGH W ++ H++ VTWLA W ++I
Sbjct: 350 GSLKRRVYPEQITINIGEGVPVPE-PLPGHQWAEVKHDNTVTWLATWHENI 399

[20][TOP]
>UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST
          Length = 780

 Score =  161 bits (408), Expect = 2e-38
 Identities = 85/173 (49%), Positives = 114/173 (65%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA FY + L+TDH     F+ NFF DF  ++ +T  + V I   EK DFS+I AH E   
Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE--- 252

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
             K  E+K   T ++K+A + E ER+ + +   L +G +E VGNFRVEPP LF GRG HP
Sbjct: 253 --KLREEKKLLTKDQKKAMKEEKERIEEPYKTCLFNGHKELVGNFRVEPPGLFRGRGAHP 310

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            TGK+KRR+ PE VTLN+G  A IPE P PGH+WG+I +++ VTWLA W+++I
Sbjct: 311 RTGKLKRRVYPEMVTLNIGAGAKIPEAP-PGHSWGEIKNDNTVTWLAMWRENI 362

[21][TOP]
>UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4XZS7_CLAL4
          Length = 764

 Score =  161 bits (407), Expect = 3e-38
 Identities = 81/173 (46%), Positives = 108/173 (62%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+A  L+TDH     F+ NFF DF  +L +     V IT  +KCDFS++ AH     
Sbjct: 182 VAGFFAEMLETDHAKNPVFQKNFFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF---- 237

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            K + EKK  + AE+   ++        +   L++GR E VGNF+VEPP+LF GRG HP 
Sbjct: 238 VKVREEKKNMSKAEKLRLKQEREALEEPYRTCLLNGRRENVGNFKVEPPSLFRGRGAHPK 297

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+K+R+ PED+TLNLG  APIP  P  GH WG+I H+  V WLA WK++I+
Sbjct: 298 TGKLKKRVYPEDITLNLGIEAPIPPAP-EGHKWGEIRHDKSVVWLAMWKENIS 349

[22][TOP]
>UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE
          Length = 2575

 Score =  160 bits (406), Expect = 4e-38
 Identities = 78/171 (45%), Positives = 113/171 (66%)
 Frame = +1

Query: 1    VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
            +A FYA  L  D+V K+ F  NF  D+RA +   +  K +T ++KCDFS I +H +    
Sbjct: 1908 IAGFYAMMLTRDYVHKDIFNENFMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQRAE 1966

Query: 181  KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
             +KA  K     E+++ +EAEA+   ++  AL+DGR+ T+GNFR+EPP LF GRG+HP  
Sbjct: 1967 ARKAASKE----EKEKRKEAEAKLKEEYGFALMDGRKVTIGNFRIEPPGLFQGRGEHPKM 2022

Query: 361  GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            GK+K R+ PEDV +N+GP   +PE P  GH W ++ H++ VTWLAGWK++I
Sbjct: 2023 GKLKLRVMPEDVIINVGPKDKVPE-PPAGHKWKEVKHDNTVTWLAGWKENI 2072

[23][TOP]
>UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59XR0_CANAL
          Length = 780

 Score =  160 bits (406), Expect = 4e-38
 Identities = 84/173 (48%), Positives = 111/173 (64%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA FY + L+TDH     F+ NFF DF  +L +     V I   EK DFS++ AH E   
Sbjct: 198 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE--- 254

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            K + EKKA +  E+K  +E + +    +    ++GR+E VGNFR+EPP LF GRG HP 
Sbjct: 255 -KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 313

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+KRR+ PE VTLNLG +A IPE P  GH WG+I H++ VTWLA WK++I+
Sbjct: 314 TGKLKRRVVPEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 365

[24][TOP]
>UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59WV6_CANAL
          Length = 780

 Score =  160 bits (406), Expect = 4e-38
 Identities = 84/173 (48%), Positives = 111/173 (64%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA FY + L+TDH     F+ NFF DF  +L +     V I   EK DFS++ AH E   
Sbjct: 198 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE--- 254

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            K + EKKA +  E+K  +E + +    +    ++GR+E VGNFR+EPP LF GRG HP 
Sbjct: 255 -KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 313

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+KRR+ PE VTLNLG +A IPE P  GH WG+I H++ VTWLA WK++I+
Sbjct: 314 TGKLKRRVVPEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 365

[25][TOP]
>UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis
           thaliana RepID=Q8RX06_ARATH
          Length = 514

 Score =  160 bits (404), Expect = 6e-38
 Identities = 81/172 (47%), Positives = 113/172 (65%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A   +TD+  K +FR NF+ D+R LL       VI  L+ CDF+ I E HLE+  
Sbjct: 6   VATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-- 60

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
              K +KK  +T E+K  +E + ++  ++  A+VDG +E +GNFRVEPP LF GRG+HP 
Sbjct: 61  ---KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPK 117

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            GK+K+RI P ++TLN+G  APIPECP+ G  W ++ H++ VTWLA W D I
Sbjct: 118 MGKLKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPI 169

[26][TOP]
>UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa
           RepID=B9I1A0_POPTR
          Length = 860

 Score =  160 bits (404), Expect = 6e-38
 Identities = 80/171 (46%), Positives = 110/171 (64%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A    T++V K +F  NF+ D+R LL       VI  LE CDF+ I    + EK 
Sbjct: 355 VATMFAVMKDTEYVQKPQFLQNFWNDWRTLLGKNH---VIQKLEACDFNPIYEWHQKEKE 411

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      +T E+K  RE + ++   +  A+V+G +E VGNFRVEPP LF GRG+HP  
Sbjct: 412 KKKQ----MSTEEKKAVREEKLKQEEMYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKM 467

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K RI+P D+T+N+G +APIP+CP+PG  W ++ H++ VTWLA W D I
Sbjct: 468 GKLKSRIRPSDITINIGKDAPIPKCPIPGERWKEVKHDNTVTWLAFWNDPI 518

[27][TOP]
>UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36
           RepID=B9WIH6_CANDC
          Length = 777

 Score =  160 bits (404), Expect = 6e-38
 Identities = 84/173 (48%), Positives = 110/173 (63%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA FY + L+TDH     F+ NFF DF  +L +     V I   EK DFS++ AH E   
Sbjct: 195 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE--- 251

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            K + EKKA +  E+K  +E + +    F    ++GR+E VGNFR+EPP LF GRG HP 
Sbjct: 252 -KLREEKKAMSKEEKKRIKEEKEKEEEPFKTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 310

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+KRR+ PE VTLNL  +A IPE P  GH WG+I H++ VTWLA WK++I+
Sbjct: 311 TGKLKRRVAPEQVTLNLSKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 362

[28][TOP]
>UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH
          Length = 916

 Score =  160 bits (404), Expect = 6e-38
 Identities = 81/172 (47%), Positives = 113/172 (65%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A   +TD+  K +FR NF+ D+R LL       VI  L+ CDF+ I E HLE+  
Sbjct: 408 VATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-- 462

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
              K +KK  +T E+K  +E + ++  ++  A+VDG +E +GNFRVEPP LF GRG+HP 
Sbjct: 463 ---KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPK 519

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            GK+K+RI P ++TLN+G  APIPECP+ G  W ++ H++ VTWLA W D I
Sbjct: 520 MGKLKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPI 571

[29][TOP]
>UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum
           RepID=Q94705_PHYPO
          Length = 1015

 Score =  159 bits (402), Expect = 1e-37
 Identities = 80/172 (46%), Positives = 113/172 (65%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L+TD+  KE F +NF++DFR  L   +  KVI    K DF+ I  +L ++K 
Sbjct: 449 VATFYAKYLETDYPKKENFNTNFWSDFRTYLTPEQ-KKVIKDFSKADFTHIHKYLVEQK- 506

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
               E KA  TAE K+A +AE E++ Q +  A+++G  + + N+ +E P LFLGRG HP 
Sbjct: 507 ----ELKANRTAEEKKAEKAEKEKLLQKYGFAMINGHRQRISNWAIERPGLFLGRGAHPK 562

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           TG VK+RI+ ED+T+N+G   P+PE P PGH W K++H+  V WLA WK++I
Sbjct: 563 TGLVKKRIEAEDITINIGKGVPVPE-PPPGHKWCKVVHDDKVAWLAMWKENI 613

[30][TOP]
>UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T3W2_PHYPA
          Length = 632

 Score =  159 bits (401), Expect = 1e-37
 Identities = 79/171 (46%), Positives = 109/171 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +AT +A  L+TD+  KE+F  NF+ D++  L       VI   E CDF+ I     D  A
Sbjct: 128 IATMFAVMLETDYAKKERFIKNFWDDWKPYLGKNH---VIKKFELCDFTPIF----DWHA 180

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           ++K  KK+ +T E+K  +E +     ++  A+VDG +E VGNFRVEPP LF GRGDHP  
Sbjct: 181 REKERKKSMSTEEKKRLKEEKLAVEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKM 240

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K RI P D+ +N+G +A +PECP+PG  W +I H++ VTWLA WKD I
Sbjct: 241 GKLKTRILPHDIVINIGKDAAVPECPIPGQRWKEIRHDNTVTWLAYWKDPI 291

[31][TOP]
>UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG
          Length = 763

 Score =  159 bits (401), Expect = 1e-37
 Identities = 78/173 (45%), Positives = 115/173 (66%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+ + L T+H     F++NFF+DF+ ++ +   A V I S +KCDFS+I  H E +K
Sbjct: 180 VACFFGAMLNTEHAQNPAFQNNFFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQK 239

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           + KK+     T A+++E +  + +   ++   L++GR E VGNFR+EPP LF GRG HP 
Sbjct: 240 SLKKS----LTAAQKREIKSEKDKFEEKYKYCLLNGRRERVGNFRIEPPGLFRGRGSHPK 295

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TG+VK+RI PEDV+LNL  +APIP  P  GH W +I H++ V WLA W++++T
Sbjct: 296 TGRVKKRIYPEDVSLNLSEDAPIPP-PPEGHQWKEIKHDNTVAWLATWRENVT 347

[32][TOP]
>UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI000198447D
          Length = 883

 Score =  158 bits (400), Expect = 2e-37
 Identities = 80/171 (46%), Positives = 106/171 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A    TD+  K +F  NF  D+R  L       VI   E CDF+ I    E EK 
Sbjct: 378 VATMFAVMKDTDYATKPRFIENFMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKE 434

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      TT E+K  +E + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 435 KKKQ----MTTEEKKALKEEKLKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKM 490

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RI P D+T+N+G  AP+PECP+PG  W ++ H++ VTWLA W D I
Sbjct: 491 GKLKKRICPSDITINIGKEAPVPECPIPGERWKEVRHDNTVTWLAFWNDPI 541

[33][TOP]
>UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7PX10_VITVI
          Length = 789

 Score =  158 bits (400), Expect = 2e-37
 Identities = 80/171 (46%), Positives = 106/171 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A    TD+  K +F  NF  D+R  L       VI   E CDF+ I    E EK 
Sbjct: 284 VATMFAVMKDTDYATKPRFIENFMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKE 340

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK      TT E+K  +E + ++  ++  A+VDG +E VGNFRVEPP LF GRG+HP  
Sbjct: 341 KKKQ----MTTEEKKALKEEKLKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKM 396

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+K+RI P D+T+N+G  AP+PECP+PG  W ++ H++ VTWLA W D I
Sbjct: 397 GKLKKRICPSDITINIGKEAPVPECPIPGERWKEVRHDNTVTWLAFWNDPI 447

[34][TOP]
>UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri
           RepID=Q00XV7_OSTTA
          Length = 783

 Score =  158 bits (399), Expect = 2e-37
 Identities = 78/171 (45%), Positives = 105/171 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +A F+A    TD+  K  F  NF   F+  LA+   A  IT   KCDF+++  H     A
Sbjct: 274 IAGFFAVMKDTDYAQKAVFVKNFMDGFKEALANGPHA-FITDFRKCDFTKMYNHF----A 328

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K + EKK  T+ E+K  +  + +    +T A +DGR E VGNFR+EPP LF GRG+HP  
Sbjct: 329 KIREEKKQMTSEEKKRIKAEKDKAEEMYTWATIDGRREKVGNFRIEPPGLFRGRGEHPKM 388

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           GK+KRR+ PED+T+N+G +A +P  P PGH+W  +IHN   TWLAGW D I
Sbjct: 389 GKIKRRVMPEDITINIGKDARVPP-PPPGHSWKAVIHNDTATWLAGWNDVI 438

[35][TOP]
>UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus
           RepID=A5E508_LODEL
          Length = 849

 Score =  158 bits (399), Expect = 2e-37
 Identities = 81/173 (46%), Positives = 112/173 (64%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+ + ++TDH     F+ NFF DF+ +L ++    V I   EK DFS+I A+ E   
Sbjct: 267 VAGFFGAMVETDHAKNPVFQKNFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE--- 323

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            KK+ EKKA +  E+K  +E +      F   L++GR+E VGNFR+EPP LF GRG HP 
Sbjct: 324 -KKREEKKAMSREEKKRLKEEKDRIEEPFKTCLLNGRKELVGNFRIEPPGLFRGRGAHPK 382

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+KRR++PE VTLNL     IPE P  GH+W ++ H++ VTWLA WK++I+
Sbjct: 383 TGKLKRRVRPEQVTLNLSKGVKIPE-PPAGHHWAEVRHDNEVTWLAMWKENIS 434

[36][TOP]
>UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL
          Length = 778

 Score =  157 bits (398), Expect = 3e-37
 Identities = 83/173 (47%), Positives = 110/173 (63%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA FY + L+TDH     F+ NFF DF  +L +     V I   EK DFS++ AH E   
Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE--- 252

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            K + EKKA +  E+K  +E + +    +    ++GR+E VGNFR+EPP LF GRG HP 
Sbjct: 253 -KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 311

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+KRR+  E VTLNLG +A IPE P  GH WG+I H++ VTWLA WK++I+
Sbjct: 312 TGKLKRRVVSEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 363

[37][TOP]
>UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH
          Length = 917

 Score =  157 bits (396), Expect = 5e-37
 Identities = 80/172 (46%), Positives = 109/172 (63%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A   +T++  K KFR NF+ D+R LL      K   SL+ CDF+ I      EK 
Sbjct: 406 VATMFAVMRETEYYKKPKFRENFWNDWRKLLGKNHMIK---SLDDCDFTPIYEWYMQEKE 462

Query: 181 KKKAEKKAQTTAERKE-AREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            KK     Q TAE K   +E + ++  ++  A++DG  E +GNFRVEPP LF GRG+HP 
Sbjct: 463 TKK-----QMTAEEKRIVKEEKLKQEEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEHPK 517

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            GK+K+RI+P D+T+N+G  APIPECP+PG  W ++ H++ VTWLA W D I
Sbjct: 518 MGKLKKRIRPCDITINIGKEAPIPECPIPGERWKEVKHDNTVTWLAFWSDPI 569

[38][TOP]
>UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FNH4_CANGA
          Length = 744

 Score =  157 bits (396), Expect = 5e-37
 Identities = 82/176 (46%), Positives = 113/176 (64%), Gaps = 3/176 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLED 171
           VA F+A+ L TDH     F+ NFF DF  +L +   T+    IT  +KCDFS++  + E 
Sbjct: 159 VAGFFANLLHTDHAKNPVFQKNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFE- 217

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
               KK EK+  +  E+K+ +  + +   +F    +DGR+E VGNFRVEPP+LF GRG H
Sbjct: 218 ---LKKEEKRNMSREEKKQIKLEKDKFEEKFKFCELDGRKEQVGNFRVEPPDLFRGRGAH 274

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           P TGK+KRR+ PED+ LNL  +APIP  P  GH+WG+I H++ V WLA WK++I G
Sbjct: 275 PKTGKLKRRVYPEDIILNLSKDAPIPPAP-QGHHWGEIRHDNTVQWLAMWKENIFG 329

[39][TOP]
>UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545
           RepID=C1MGX0_9CHLO
          Length = 685

 Score =  156 bits (395), Expect = 7e-37
 Identities = 75/171 (43%), Positives = 108/171 (63%), Gaps = 1/171 (0%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKA 180
           A F+A    TD+  K+ F  NF+  F+ +L     A  I   +KCDF+++   HL     
Sbjct: 202 ANFFAVMKDTDYAQKDVFVKNFWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHL----- 256

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K++ +KKA +  ++K+A+ A+     ++  A++DGR E VGNFRVEPP LF GRG+HP  
Sbjct: 257 KEREKKKAISNEDKKKAKAAKDAEEEKYNWAVIDGRRERVGNFRVEPPGLFRGRGEHPKM 316

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G++K+RI PED+T+N+G   P P+ P PGH W  +IHN  VTWL GW D+I
Sbjct: 317 GRIKKRIMPEDITINIGKGVPAPD-PGPGHKWKDVIHNDTVTWLCGWNDTI 366

[40][TOP]
>UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8IDM1_CHLRE
          Length = 586

 Score =  155 bits (392), Expect = 2e-36
 Identities = 77/173 (44%), Positives = 111/173 (64%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A   +TD++ K+ F  NF+  F+ +L       VI  L+KCDF+ I + H+   +
Sbjct: 68  VATMFAVMKETDYMNKKVFLDNFWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQRE 124

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           AKK   K+     E+   ++ + E+  ++ VA VDGR E VGNFRVEPP LF GRG+HP 
Sbjct: 125 AKKGISKE-----EKDRIKKEKDEKEAKYKVAYVDGRPEPVGNFRVEPPGLFRGRGEHPK 179

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
            GK+K+R+ P D+T+N+G N P+PE P PG  W ++ H+  VTWLA WKD+I+
Sbjct: 180 MGKIKKRVYPRDITINIGENEPVPEHPYPGQTWKEVKHDHTVTWLAYWKDTIS 232

[41][TOP]
>UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera
           RepID=UPI0000DB758E
          Length = 973

 Score =  155 bits (391), Expect = 2e-36
 Identities = 72/173 (41%), Positives = 111/173 (64%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L  D+  K  F SNFF D+R ++ +++  K++  L KC+F  I A+      
Sbjct: 482 VATFYARMLDHDYTTKPAFNSNFFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----I 536

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           +K  E+KA T  E+++ +E   E  +++   ++DG +E +GNF++EPP LF GRG+HP  
Sbjct: 537 QKSEERKAMTKEEKQKIKEKNEEIQKEYGYCIIDGHKEKIGNFKIEPPGLFRGRGEHPKM 596

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           GK+K+R+ PED+ +N   ++ IP+ P PGH W +I H+  VTWLA W ++I G
Sbjct: 597 GKLKKRVMPEDILINCSKDSNIPK-PPPGHKWKEIRHDPNVTWLASWTENIQG 648

[42][TOP]
>UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea
           okayama7#130 RepID=A8N6Y9_COPC7
          Length = 863

 Score =  155 bits (391), Expect = 2e-36
 Identities = 77/173 (44%), Positives = 109/173 (63%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174
           VA FY + L+TDH     F  NFF DF+ +L     +    IT+ E CDF  +  + E E
Sbjct: 297 VAGFYGALLETDHAKDATFNKNFFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAE 356

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
           KAK+KA     T  E+K A++ + E   ++   ++DGR+E VGNFR+EPP LF GRG+HP
Sbjct: 357 KAKRKA----MTNEEKKAAKKKKDELEEKYKTCVMDGRKEKVGNFRIEPPGLFRGRGEHP 412

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
             G +K+R+ PED+T+N+G  A IP   +PG  W K+IH++ VTWLA W ++I
Sbjct: 413 KKGSLKKRVYPEDITINIGKEAKIPVPNIPG-KWKKVIHDNTVTWLATWTENI 464

[43][TOP]
>UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404
           RepID=C5M985_CANTT
          Length = 777

 Score =  154 bits (390), Expect = 3e-36
 Identities = 81/173 (46%), Positives = 110/173 (63%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA FY + L+TDH     F+ NFF DF  +L +     V I   EK DFS++ A+ E ++
Sbjct: 195 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKEFEKMDFSKMYAYYEQQR 254

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
                EKKA +  E+K  +E   +    +    ++GR+E VGNFR+EPP LF GRG HP 
Sbjct: 255 E----EKKALSRDEKKRLKEERDKFEEPYKTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 310

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+KRR+ PE VTLNLG +A +PE P  GH WG+I H++ VTWLA WK++I+
Sbjct: 311 TGKLKRRVAPEQVTLNLGKDAKVPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 362

[44][TOP]
>UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans
           RepID=Q5KB99_CRYNE
          Length = 881

 Score =  154 bits (388), Expect = 5e-36
 Identities = 82/176 (46%), Positives = 111/176 (63%), Gaps = 3/176 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174
           VA F+ + L+TD+    KFR NFF DF+A++     K    +  LEKCDF  +  + E E
Sbjct: 298 VAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKE 357

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 351
           K KKKA      T E K+A +AE +++   +  A VDGR+E VGNFR EPP LF GRG+H
Sbjct: 358 KEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEH 412

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           P  G VK R++PED+ +N+G  APIP   +PG  W  I H++ VTWLA WK+++ G
Sbjct: 413 PKKGTVKNRLRPEDIIINIGKEAPIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNG 467

[45][TOP]
>UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans
           RepID=O59891_CRYNE
          Length = 844

 Score =  154 bits (388), Expect = 5e-36
 Identities = 82/176 (46%), Positives = 111/176 (63%), Gaps = 3/176 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174
           VA F+ + L+TD+    KFR NFF DF+A++     K    +  LEKCDF  +  + E E
Sbjct: 261 VAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKE 320

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 351
           K KKKA      T E K+A +AE +++   +  A VDGR+E VGNFR EPP LF GRG+H
Sbjct: 321 KEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEH 375

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           P  G VK R++PED+ +N+G  APIP   +PG  W  I H++ VTWLA WK+++ G
Sbjct: 376 PKKGTVKNRLRPEDIIINIGKEAPIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNG 430

[46][TOP]
>UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP
           RepID=B2WCA4_PYRTR
          Length = 905

 Score =  153 bits (387), Expect = 6e-36
 Identities = 85/181 (46%), Positives = 108/181 (59%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VATFY S L + H V    F  NFF DF A+L  T   K        I   EKCDF  I 
Sbjct: 314 VATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKPIF 373

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
              + E+AKKKA   A+  A + E   AEA+    +   L DGR++ VGNFRVEPP LF 
Sbjct: 374 EWFDAERAKKKALSAAEKKALKAEKEAAEAD----YMYCLWDGRKQKVGNFRVEPPGLFR 429

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK+R+ PE +T+N+G NA +PE P  GH W +I H+   TWLA W+++I 
Sbjct: 430 GRGEHPKTGRVKKRVMPEQITINIGENAKVPE-PPAGHRWKEIKHDHEGTWLAMWQENIN 488

Query: 517 G 519
           G
Sbjct: 489 G 489

[47][TOP]
>UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA
          Length = 892

 Score =  152 bits (384), Expect = 1e-35
 Identities = 74/167 (44%), Positives = 106/167 (63%)
 Frame = +1

Query: 13  YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA 192
           YA    TD++ K++F+ NF+ D+R LL       VI +L+ CDF+ I    + EK KKK 
Sbjct: 386 YAVMRDTDYMQKDRFKENFWNDWRKLLGRNH---VIQNLKDCDFTPIYDWCQSEKEKKKQ 442

Query: 193 EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVK 372
                TT E+K  +E + ++  ++T A+VDG +  VGNFRVEPP LF GRG+HP  G++K
Sbjct: 443 ----MTTEEKKALKEEKLKQEEKYTWAIVDGVKRRVGNFRVEPPGLFRGRGEHPKMGRLK 498

Query: 373 RRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           +RI P D+ +N+G  A +PECP+PG  W  I +++ VTWL  W D I
Sbjct: 499 KRIHPSDIVINIGSEAQVPECPIPGEGWKDIRNDNTVTWLCYWSDPI 545

[48][TOP]
>UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6JVY3_SCHJY
          Length = 654

 Score =  152 bits (384), Expect = 1e-35
 Identities = 75/175 (42%), Positives = 106/175 (60%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDE 174
           VA F+ + L++DH     F+ NFF DF+A+   A  K A +      CDF  +  + E  
Sbjct: 279 VAGFFGALLESDHAQNPTFQKNFFRDFQAVCKEAGMKSADIPKEFNSCDFRPMFEYFESL 338

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
           K  KK   K     E+KE ++ + E   +F   L+DGR+E VGNFR+EPP LF GRG HP
Sbjct: 339 KEAKKNMSKE----EKKELKKKKEEEEEKFKWCLLDGRKEKVGNFRIEPPGLFRGRGSHP 394

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            TG +KRR+ PE +T+N+G  A +PE P+PGH W ++ H+  VTWLA W +++ G
Sbjct: 395 KTGTLKRRVYPEQITINIGKGAKVPE-PLPGHKWAEVRHDDQVTWLAMWHENVNG 448

[49][TOP]
>UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora
           DSM 70294 RepID=A7TJW1_VANPO
          Length = 799

 Score =  152 bits (384), Expect = 1e-35
 Identities = 79/175 (45%), Positives = 109/175 (62%), Gaps = 3/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEK---CDFSRIEAHLED 171
           VA F+A+ L TDH     F+ NFF DF+ +L +         LEK   CDFS++  + E 
Sbjct: 214 VAGFFAALLHTDHAKNTVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEI 273

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
           ++     ++K  +  E+K+ R  + E+   F    +DGR E VGNFRVEPP+LF GRG H
Sbjct: 274 QRE----QRKKLSPQEKKQLRLEKEEQEEPFKFCELDGRREQVGNFRVEPPDLFRGRGAH 329

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           P TGK+KRR+ PED+ LNL  NAPIP  P  GH WG+I H++ V WLA W+++I+
Sbjct: 330 PKTGKLKRRVYPEDIVLNLDRNAPIPAVP-EGHKWGEIKHDNTVQWLAMWRENIS 383

[50][TOP]
>UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186E5D8
          Length = 961

 Score =  152 bits (383), Expect = 2e-35
 Identities = 73/173 (42%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L  D+  KEKF +NFF D+R ++ D K  KVIT L KC+F  +  + ++   
Sbjct: 460 VATFYAKMLTHDYTTKEKFNTNFFNDWRKVMTD-KERKVITDLSKCNFKPMALYFQE--- 515

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            K  E+KA +  E+K  ++      +++    +DG +E +GNFR+EPP LF GRG+HP  
Sbjct: 516 -KSEERKAMSKEEKKVIKDQNDAIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKM 574

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +K+R+ PEDV +N   ++ IP+ P  GH W K+ H+  VTWLA W +++ G
Sbjct: 575 GMLKKRVLPEDVIINCSKDSKIPK-PPDGHKWKKVQHDPSVTWLASWTENVQG 626

[51][TOP]
>UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio
           RepID=Q6T721_DANRE
          Length = 600

 Score =  152 bits (383), Expect = 2e-35
 Identities = 76/172 (44%), Positives = 110/172 (63%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +ATFYA  L  ++  KE F+ NFF D+R  +   +  K+IT+L KCDF+ I  +  +   
Sbjct: 92  IATFYAKMLDHEYTTKEVFQKNFFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE--- 147

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
             KAE+K   T E K+  + EA R+  +F   L+DG  E +GNF++EPP LF GRG+HP 
Sbjct: 148 --KAEEKKNMTKEEKQVLKDEAARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPK 205

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G++K+RIQPEDV +N   ++ IPE P  GH W ++ H++ VTWLA W ++I
Sbjct: 206 MGRLKKRIQPEDVAINCSKDSKIPE-PPAGHKWKRVQHDNTVTWLASWLENI 256

[52][TOP]
>UniRef100_A9T368 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T368_PHYPA
          Length = 502

 Score =  152 bits (383), Expect = 2e-35
 Identities = 75/168 (44%), Positives = 106/168 (63%), Gaps = 1/168 (0%)
 Frame = +1

Query: 13  YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKK 189
           +A  ++TD+  KE+F  NF+ D++  L       VI   E CDF+ I + H     A++K
Sbjct: 2   FAVMIETDYAKKERFVKNFWDDWKPYLGKNH---VIKKFELCDFTPIFQWH-----AREK 53

Query: 190 AEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKV 369
             KK  +  E+K  +E +     ++  A+VDG +E VGNFRVEPP LF GRGDHP  GK+
Sbjct: 54  ERKKNMSAEEKKRLKEEKLAAEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKMGKL 113

Query: 370 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           K RI P D+ +N+G +AP+PECP+PG  W ++ H++ VTWLA WKD I
Sbjct: 114 KTRILPHDIVINIGKDAPVPECPIPGQKWKEVRHDNTVTWLAYWKDPI 161

[53][TOP]
>UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FVE9_CANGA
          Length = 717

 Score =  152 bits (383), Expect = 2e-35
 Identities = 81/176 (46%), Positives = 109/176 (61%), Gaps = 3/176 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLED 171
           VA F+A  L+T H     F+ NFF DF+ +L D   T+    I S ++ DFS     + D
Sbjct: 132 VAGFFAHLLETPHAQNPVFQKNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHD 187

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
              + K EKK+ T  ++KE R    +   ++    +DGR E VGNF+VEPP+LF GRG H
Sbjct: 188 YFVQLKEEKKSMTAMQKKEIRLEREKFEEKYKFCELDGRREQVGNFKVEPPDLFRGRGAH 247

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           P TGK+KRRI+PED+ LNLG  APIP  P  GH WG+I H++ V WLA W+++I G
Sbjct: 248 PKTGKLKRRIRPEDIVLNLGEGAPIPP-PPSGHQWGEIRHDNTVQWLAMWRENIFG 302

[54][TOP]
>UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC
           6260 RepID=UPI000151AE34
          Length = 754

 Score =  151 bits (382), Expect = 2e-35
 Identities = 75/173 (43%), Positives = 110/173 (63%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+A+ L+TDH     F+ NF+ DF  ++ ++  A V +    K DF+++ AH E   
Sbjct: 172 VAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE--- 228

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
              K +KK  +  E+K  +EA+ +    +   L++GR+E VGNFRVEPP LF GRG HP 
Sbjct: 229 -MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPK 287

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+K+R+ PED+TLNL     +PE P  GH WG++ H++ V WLA WK++I+
Sbjct: 288 TGKLKKRVYPEDITLNLSKECKVPE-PPAGHKWGEVRHDNTVAWLAMWKENIS 339

[55][TOP]
>UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii
           RepID=A5DLX4_PICGU
          Length = 754

 Score =  151 bits (382), Expect = 2e-35
 Identities = 75/173 (43%), Positives = 110/173 (63%), Gaps = 1/173 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+A+ L+TDH     F+ NF+ DF  ++ ++  A V +    K DF+++ AH E   
Sbjct: 172 VAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE--- 228

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
              K +KK  +  E+K  +EA+ +    +   L++GR+E VGNFRVEPP LF GRG HP 
Sbjct: 229 -MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPK 287

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           TGK+K+R+ PED+TLNL     +PE P  GH WG++ H++ V WLA WK++I+
Sbjct: 288 TGKLKKRVYPEDITLNLSKECKVPE-PPAGHKWGEVRHDNTVAWLAMWKENIS 339

[56][TOP]
>UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia
            vitripennis RepID=UPI00015B4D8F
          Length = 1019

 Score =  151 bits (381), Expect = 3e-35
 Identities = 72/173 (41%), Positives = 111/173 (64%)
 Frame = +1

Query: 1    VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
            VATFYA  L+ D+  K+ F  NFF D+R ++ +++ AK IT L+KC+F+ +  +      
Sbjct: 512  VATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAK-ITDLKKCNFTEMHKYF----I 566

Query: 181  KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
             K  E+KA +  E+K  +E   E  +++ +  +DG +E +GNF++EPP LF GRG+HP  
Sbjct: 567  MKSEERKAMSKEEKKAIKEKNDEIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHPKM 626

Query: 361  GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            GK+K+R+ PEDV +N   ++  P+ P PGH W +I H+  VTWLA W ++I G
Sbjct: 627  GKLKKRLVPEDVLINCSKDSVHPK-PPPGHKWKEIRHDPTVTWLASWTENIQG 678

[57][TOP]
>UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299
           RepID=C1FD86_9CHLO
          Length = 635

 Score =  150 bits (380), Expect = 4e-35
 Identities = 79/174 (45%), Positives = 107/174 (61%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A    TD+  K+ F  NFF  F+  L        I   +KCDF++I      E+ 
Sbjct: 149 VATFFAVMKDTDYAQKDIFVKNFFDGFKKTLRGGPHG-FIKDFKKCDFTKIYMWNLQERE 207

Query: 181 KKK---AEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
           +KK   AE+K +  AE+  A E       ++  A +DGR E VGN++VEPP LF GRG+H
Sbjct: 208 RKKSVSAEEKRKVKAEQAAAEE-------KYCWATIDGRRERVGNYKVEPPGLFRGRGEH 260

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           P  G+VK+RI PED+ +N+G  A +PE P+PGH W +IIHN+ VTWL GW D+I
Sbjct: 261 PKMGRVKKRIMPEDIIINIGKGAKVPE-PLPGHKWKQIIHNNTVTWLCGWNDTI 313

[58][TOP]
>UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum
           RepID=Q0UUB0_PHANO
          Length = 887

 Score =  149 bits (376), Expect = 1e-34
 Identities = 81/180 (45%), Positives = 106/180 (58%), Gaps = 8/180 (4%)
 Frame = +1

Query: 4   ATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEA 159
           ATFY S L + H V    F  NFF DF A+L  T   K        I   EKCDF  I  
Sbjct: 297 ATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDFKPIFE 356

Query: 160 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 339
           H E ++A KKA   A+  A + E   AEAE    +   + DGR++ VGNFRVEPP LF G
Sbjct: 357 HFEADRAAKKALPAAEKKALKAEKDAAEAE----YMFCMWDGRKQKVGNFRVEPPGLFRG 412

Query: 340 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           RG+HP TG++K+R+ PE +T+N+G NA +P  P  GH W ++ H+   TWLA W+++I G
Sbjct: 413 RGEHPKTGRIKKRVAPEQITINIGENAKVPP-PPAGHRWKEVKHDHEGTWLAMWQENING 471

[59][TOP]
>UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes
           RepID=TOP1M_PANTR
          Length = 601

 Score =  148 bits (373), Expect = 2e-34
 Identities = 76/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY   L  ++  KE FR NFF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A
Sbjct: 92  VATFYGRMLGHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAA 150

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +K   +     E K+  + EAE++ R+F   ++DG +E +GNF++EPP LF GRGDHP 
Sbjct: 151 ARKVLSR-----EEKQKLKEEAEKLQREFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPK 205

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRRI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +S+
Sbjct: 206 MGMLKRRIMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 256

[60][TOP]
>UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens
           RepID=TOP1M_HUMAN
          Length = 601

 Score =  148 bits (373), Expect = 2e-34
 Identities = 76/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY   L  ++  KE FR NFF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A
Sbjct: 92  VATFYGRMLDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAA 150

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +K   +     E K+  + EAE+++Q F   ++DG +E +GNF++EPP LF GRGDHP 
Sbjct: 151 ARKVLSR-----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPK 205

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRRI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +S+
Sbjct: 206 MGMLKRRITPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 256

[61][TOP]
>UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DEP3_LACTC
          Length = 756

 Score =  147 bits (370), Expect = 6e-34
 Identities = 78/176 (44%), Positives = 110/176 (62%), Gaps = 4/176 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLED 171
           VA F+A+ L++DH     F+ NFF DF  +L +    K    I   E CDFS++  + + 
Sbjct: 171 VAGFFAALLESDHAQNPVFQKNFFNDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQL 230

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 348
           +K +KK     Q +++ K+  + E E+  + F    +DGR+E VGNFR+EPP LF GRG 
Sbjct: 231 QKEQKK-----QLSSQEKKKLKIEKEQFEEPFKFCFLDGRKEQVGNFRIEPPGLFRGRGA 285

Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           HP TGK+KRR+ PEDV LNL   A IP+ P  GH WG+I H+S V WLA W+++I+
Sbjct: 286 HPKTGKLKRRVYPEDVVLNLDKEAEIPKAP-EGHKWGEIRHDSTVQWLAMWRENIS 340

[62][TOP]
>UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO
          Length = 1043

 Score =  146 bits (368), Expect = 9e-34
 Identities = 70/173 (40%), Positives = 107/173 (61%), Gaps = 1/173 (0%)
 Frame = +1

Query: 4    ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
            ATFYA  L  D+  K+ F +NFF DFR  +   K  ++I    KC+F  +  + + E  K
Sbjct: 537  ATFYAKMLNHDYCTKDVFNNNFFKDFRKTMTP-KEKEIIKDFRKCNFQEMFEYFQAESEK 595

Query: 184  KKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            +KA      T E K A++ E+E  ++++   ++DG +E +GNFR+EPP LF GRG+HP  
Sbjct: 596  RKA-----ATKEEKLAKKVESEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 650

Query: 361  GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI   DV++N G N+ +P+ P PG  W ++ H++ VTWLA W +++ G
Sbjct: 651  GMIKRRIAARDVSINCGKNSKVPQ-PPPGERWKEVRHDNTVTWLASWTENVQG 702

[63][TOP]
>UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio
           rerio RepID=UPI0001760D92
          Length = 748

 Score =  145 bits (366), Expect = 2e-33
 Identities = 73/174 (41%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L+ ++   E FR NFF D+R  +   + +K IT L+KCDF+++  +      
Sbjct: 239 VATFYAKMLEHEYTTNEIFRKNFFKDWRKEMTSEEKSK-ITELKKCDFTQMHEYF----- 292

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + E ER+ Q +   L+D   E +GNFR+EPP LF GRGDHP 
Sbjct: 293 KAQSEARKQMSKEEKQKNKEENERILQEYGFCLMDNHRERIGNFRIEPPGLFRGRGDHPK 352

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            GK+KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWL  W ++I G
Sbjct: 353 MGKLKRRIRPEDIIINCSKDSVQPKAP-PGTRWKEVRHDNKVTWLVSWTENIQG 405

[64][TOP]
>UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii
           CBS767 RepID=UPI00003BE191
          Length = 789

 Score =  145 bits (366), Expect = 2e-33
 Identities = 76/173 (43%), Positives = 106/173 (61%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+ +  +TDH     F+ NFF DF  +L D     V I    + DFS++ AH E  +
Sbjct: 207 VAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLR 266

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
            +KK   K     + K+A +AE ++  + +   L++G +E VGNFR+EPP LF GRG HP
Sbjct: 267 DQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHP 321

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            TGK+KRR+ PEDVTLNL     IPE P  GH W ++ H++ V+WLA WK++I
Sbjct: 322 KTGKLKRRVMPEDVTLNLSEGCKIPE-PPQGHKWAEVRHDNTVSWLAMWKENI 373

[65][TOP]
>UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi
           RepID=A8Q2Z1_BRUMA
          Length = 751

 Score =  145 bits (366), Expect = 2e-33
 Identities = 68/173 (39%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA+FYA  L+ ++  K+ F  NFF D+R ++   +  K IT L KCDF  +  H      
Sbjct: 252 VASFYAKILEHEYTTKDIFNKNFFTDWRKVMTPAEREK-ITDLTKCDFREMHDHY----I 306

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K + E+++ +  E+++ +E + E  + + VA +DG ++ +GNFR+EPP+LF GRG HP  
Sbjct: 307 KLREERRSLSKEEKQKLKEIKQEEAKIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHPKM 366

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G++K+R+ PEDV +N   ++ IP+ P  GH W ++ H++ VTWL  W D+I G
Sbjct: 367 GRLKKRVNPEDVIINCSKDSEIPK-PPEGHRWKEVRHDNTVTWLCSWTDNILG 418

[66][TOP]
>UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA
          Length = 789

 Score =  145 bits (366), Expect = 2e-33
 Identities = 76/173 (43%), Positives = 106/173 (61%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177
           VA F+ +  +TDH     F+ NFF DF  +L D     V I    + DFS++ AH E  +
Sbjct: 207 VAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLR 266

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
            +KK   K     + K+A +AE ++  + +   L++G +E VGNFR+EPP LF GRG HP
Sbjct: 267 DQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHP 321

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            TGK+KRR+ PEDVTLNL     IPE P  GH W ++ H++ V+WLA WK++I
Sbjct: 322 KTGKLKRRVMPEDVTLNLSEGCKIPE-PPQGHKWAEVRHDNTVSWLAMWKENI 373

[67][TOP]
>UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q9Y0_IXOSC
          Length = 499

 Score =  145 bits (365), Expect = 2e-33
 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FY   L  D+  KE F  NFF D+R  +   K A++IT L KC+F  I+ +      
Sbjct: 270 VAGFYGRMLDHDYTSKEAFNKNFFKDWRKTMTP-KEAELITDLSKCNFKEIDVYY----- 323

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K+K+E++   + E K+A +A+ E++  ++   ++DG  + +GNF++EPP LF GRG+HP 
Sbjct: 324 KQKSEERKAMSKEEKQAIKAQNEKLLEEYGFCIIDGHRQKIGNFKIEPPGLFRGRGEHPK 383

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRR+ PEDV +N+G  A IP  P  GH W ++ H++ V+WL+ W ++I G
Sbjct: 384 MGMLKRRVMPEDVIINIGKEAKIPP-PPEGHRWKEVRHDNTVSWLSSWTENILG 436

[68][TOP]
>UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO
          Length = 732

 Score =  145 bits (365), Expect = 2e-33
 Identities = 74/175 (42%), Positives = 111/175 (63%), Gaps = 3/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV---ITSLEKCDFSRIEAHLED 171
           VA F+A+ LQ+DH     F+ NFF DF ++L     A+    I    KCDFS++ A+++ 
Sbjct: 147 VAGFFAALLQSDHAQNPVFQKNFFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQ 206

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
           ++     + K  ++ ERK  ++ + +      V L+ GR+E V  F+++PP+LF GRG H
Sbjct: 207 QRV----QMKQLSSHERKLLKQEKGQTEGPVQVLLLTGRKEQVDTFKIDPPDLFRGRGAH 262

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           P TGK+KRR+QPEDV LNL  +APIPE P  GH WG+I H++ V WL  W+++I+
Sbjct: 263 PKTGKLKRRVQPEDVVLNLDKDAPIPE-PPAGHKWGEIRHDNTVQWLCMWRENIS 316

[69][TOP]
>UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA
          Length = 909

 Score =  144 bits (364), Expect = 3e-33
 Identities = 73/167 (43%), Positives = 108/167 (64%), Gaps = 1/167 (0%)
 Frame = +1

Query: 22  KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKK 201
           ++ T+++ K  FR N   D++ +L       +I +L+ CDF+ I      E  + K EKK
Sbjct: 395 QILTEYLTKPVFRENVMNDWKIILGRNH---IIKNLDDCDFTPIY-----EWFRLKKEKK 446

Query: 202 AQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRR 378
            Q +AE K+A +E + ++  ++  A+VDG +E VGNFRVEPP LF GR   P  GK+K+R
Sbjct: 447 KQMSAEEKKAVKEEKLKQEEKYMWAVVDGVKENVGNFRVEPPGLFRGRESIPKMGKLKKR 506

Query: 379 IQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           I P D+T+N+G +APIPECP+PG +W ++ H++ VTWLA W D I G
Sbjct: 507 ISPSDITINIGKDAPIPECPIPGESWKEVRHDNTVTWLAYWNDPING 553

[70][TOP]
>UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DC43
          Length = 343

 Score =  144 bits (363), Expect = 4e-33
 Identities = 79/173 (45%), Positives = 105/173 (60%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIEAHLEDE 174
           VA FYA+ ++TDH     F  NFF D+  +L D      I  T  +KCDF  +  + E E
Sbjct: 20  VAGFYAALIETDHAQDAAFNKNFFEDWLKVLQDHPPCNGIKATDFDKCDFRPMYEYFEAE 79

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
           KAKKKA   A+    +K+  EAEA+   +F    +DGR+E VGNFRVEPP LF GRG+HP
Sbjct: 80  KAKKKATSAAEKKEIKKQKDEAEAKYTHRF----LDGRKEKVGNFRVEPPGLFRGRGEHP 135

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
             G +K R+ PED+ LN+G +AP P   +PG  W  I H++ VTWLA   ++I
Sbjct: 136 KKGSLKYRVCPEDIALNIGKDAPTPIPNIPG-KWKAIQHDNTVTWLATRTENI 187

[71][TOP]
>UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1
           Tax=Tribolium castaneum RepID=UPI00017582B6
          Length = 936

 Score =  144 bits (363), Expect = 4e-33
 Identities = 69/172 (40%), Positives = 109/172 (63%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA+FY+  L  D+  KE F +NFF D+R ++++++  KVI  L+KC+F  + A+  D   
Sbjct: 429 VASFYSKMLDHDYTTKEVFNNNFFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMD--- 484

Query: 181 KKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
              AEK    T E K+A +E     ++++    +DG +E +GNF++EPP LF GRG+HP 
Sbjct: 485 --LAEKNRNRTKEEKQALKEKNEALIKEYGFCNIDGHKEKIGNFKIEPPGLFRGRGEHPK 542

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRR++ ED+ +N   ++ IPE P PGH W ++ H+  VTWLA W +++
Sbjct: 543 MGMLKRRVEAEDIIINCSQDSKIPE-PPPGHKWKEVRHDDNVTWLASWTENV 593

[72][TOP]
>UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus
           RepID=UPI00017968A4
          Length = 655

 Score =  144 bits (362), Expect = 5e-33
 Identities = 74/172 (43%), Positives = 108/172 (62%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY   L  ++  KE F++NFF+D+R  +   +  K+I  L+KCDF+ I  +  D+ A
Sbjct: 146 VATFYGKMLDHEYTTKEVFQNNFFSDWRKEMTAEE-RKIIKHLDKCDFTEIHRYFVDKTA 204

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +KA  +     E K+  + EAE+++Q F    +DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 205 ARKALSR-----EEKQKLKEEAEKLQQEFGYCTLDGHREKIGNFKTEPPGLFRGRGDHPK 259

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRRI PEDVT+N   ++ IP+ P  GH W ++  ++ VTWLA W ++I
Sbjct: 260 MGMLKRRILPEDVTINCSRDSKIPK-PPAGHQWKEVRSDNTVTWLASWTENI 310

[73][TOP]
>UniRef100_B8CC91 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B8CC91_THAPS
          Length = 536

 Score =  144 bits (362), Expect = 5e-33
 Identities = 68/153 (44%), Positives = 97/153 (63%)
 Frame = +1

Query: 55  FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 234
           F  NFF DFR +L       +I   +KCDF  I+ HL ++K  +KA     T  ERK  +
Sbjct: 12  FIKNFFTDFRTILGKNH---IIKDFKKCDFGPIQRHLNEQKLIRKAI----TDEERKVNK 64

Query: 235 EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 414
           +++ E + +F  ALVDG  E VGN+ +EPP  F GRG+HP  GK+K+R++PE V +N+  
Sbjct: 65  DSKNETLFKFGYALVDGHLEKVGNYNMEPPGAFRGRGEHPKMGKLKQRVEPEQVMINVSE 124

Query: 415 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           +AP+P C VPGH WG++ H+  V WL  WK++I
Sbjct: 125 DAPVPMCSVPGHAWGEVRHDPTVQWLCQWKENI 157

[74][TOP]
>UniRef100_A4S5R8 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4S5R8_OSTLU
          Length = 491

 Score =  144 bits (362), Expect = 5e-33
 Identities = 73/161 (45%), Positives = 97/161 (60%)
 Frame = +1

Query: 31  TDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 210
           +D+  K  F  NF   F+A L +   A  IT   KCDF+++  H    + KKK      T
Sbjct: 4   SDYATKPVFVKNFMDGFKAALKNGPHA-FITDFSKCDFTKMYMHFLAIREKKKE----MT 58

Query: 211 TAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPE 390
           + E+K  +  +      +T A +DGR E VGNFRVEPP LF GRG+HP  GK+KRR+ PE
Sbjct: 59  SEEKKRIKAQKDIDEEPYTWATIDGRREKVGNFRVEPPGLFRGRGEHPKMGKIKRRVVPE 118

Query: 391 DVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           D+T+N+G +A +PE P  GH+W  +IHN   TWLAGW D I
Sbjct: 119 DITINIGKDAKVPE-PPAGHSWKAVIHNDTATWLAGWNDVI 158

[75][TOP]
>UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN
          Length = 990

 Score =  144 bits (362), Expect = 5e-33
 Identities = 68/172 (39%), Positives = 104/172 (60%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  K+ F +NFF DFR  +  +K  ++I    KC+F  +  + + E  K
Sbjct: 498 ATFYAKMLNHDYCTKDVFNTNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEK 556

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +  A++ E        V+++   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 557 RKAATKEEKLAKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 612

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G  + +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 613 MIKRRIQASDVSINCGKESHVPS-PPPGQRWKEVRHDNTVTWLASWIENVQG 663

[76][TOP]
>UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B1
          Length = 751

 Score =  143 bits (361), Expect = 6e-33
 Identities = 73/173 (42%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  +    KA
Sbjct: 242 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KA 297

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A +KA T  E+ + +E     ++QF   ++D  +E + NFR+EPP LF GRGDHP  
Sbjct: 298 QTEA-RKAMTKEEKLKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 356

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI+PED+ +N   ++  PE P PG  W ++ H++ VTWL  W ++I G
Sbjct: 357 GMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQG 408

[77][TOP]
>UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B0
          Length = 751

 Score =  143 bits (361), Expect = 6e-33
 Identities = 73/173 (42%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  +    KA
Sbjct: 242 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KA 297

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A +KA T  E+ + +E     ++QF   ++D  +E + NFR+EPP LF GRGDHP  
Sbjct: 298 QTEA-RKAMTKEEKLKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 356

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI+PED+ +N   ++  PE P PG  W ++ H++ VTWL  W ++I G
Sbjct: 357 GMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQG 408

[78][TOP]
>UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA
          Length = 763

 Score =  143 bits (361), Expect = 6e-33
 Identities = 71/172 (41%), Positives = 106/172 (61%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEK-FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 177
           VA F+ + L ++  +K   F+ NFF DF+     T    +    E CDF+ +  + E   
Sbjct: 181 VAGFFGAILSSEQYVKNPTFQKNFFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFE--- 237

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            KKK EKK ++  E+K+ +E +     ++    +DGR+E VGNFR+EPP LF GRGDHP 
Sbjct: 238 -KKKEEKKNKSKEEKKKIKEEKDALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDHPK 296

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           TGK+K R+ PE V +N+G ++ IP  P PGHNW ++ H++ VTWLA W +++
Sbjct: 297 TGKLKTRVVPEQVIINIGKDSVIPS-PPPGHNWKEVRHDNTVTWLATWNENV 347

[79][TOP]
>UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732
           RepID=C5DTC9_ZYGRC
          Length = 843

 Score =  143 bits (361), Expect = 6e-33
 Identities = 78/176 (44%), Positives = 110/176 (62%), Gaps = 4/176 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLED 171
           VA F+A+ LQ+DH     F+SNFF DF  +L +   TK    I S +KCDF+++    E 
Sbjct: 258 VAGFFAALLQSDHAKNTVFQSNFFNDFIEVLNENGGTKNGINIESFDKCDFTKMFEFFEM 317

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 348
           +K ++K     Q + + K+    E E+  + F    +DGR+E VGNF++EPP LF GRG 
Sbjct: 318 QKEQRK-----QLSPQEKKQLRMEREKFEEPFKYCELDGRKEQVGNFKIEPPGLFRGRGA 372

Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           HP TGK+KRR+ PEDV LNL  +A IP  P  G  WG+I H++ V WLA W+++I+
Sbjct: 373 HPKTGKLKRRVYPEDVVLNLDKDATIPPLP-EGQKWGEIRHDNTVQWLAMWRENIS 427

[80][TOP]
>UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B5Y3I3_PHATR
          Length = 594

 Score =  142 bits (359), Expect = 1e-32
 Identities = 71/153 (46%), Positives = 92/153 (60%)
 Frame = +1

Query: 55  FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 234
           F  NFFADFR +L      K     +KCDF  I  HL ++K  +KA     T  ERK  +
Sbjct: 78  FIKNFFADFREILGKKHIVK---EFKKCDFEPIRKHLNEQKIIRKAI----TDEERKANK 130

Query: 235 EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 414
           E  ++ + QF  ++VDG  E VGNF +EPP  F GRG+HP  GK+K R+ PE V+LNL  
Sbjct: 131 EDRSQTLHQFGFSIVDGHIERVGNFNMEPPGAFRGRGEHPKMGKLKSRVLPEQVSLNLSE 190

Query: 415 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            AP+P CPVPGH W  + H+    WLA WK++I
Sbjct: 191 CAPVPPCPVPGHAWSDVRHDPRGQWLATWKENI 223

[81][TOP]
>UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA
           n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC
          Length = 884

 Score =  142 bits (359), Expect = 1e-32
 Identities = 77/181 (42%), Positives = 107/181 (59%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VA F+   L  T HV    F+ NFF DFR +L  T  AK        I    KCDF  I 
Sbjct: 293 VAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQPIF 352

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
           A+ ++++     EKKA   AE+K  +  +  +   +   + DGR++ VGNFRVEPP LF 
Sbjct: 353 AYYDNQRQ----EKKALPPAEKKRLKAEKDAQEAPYMFCMWDGRKQKVGNFRVEPPALFR 408

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G +AP+P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 409 GRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 467

Query: 517 G 519
           G
Sbjct: 468 G 468

[82][TOP]
>UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum
           RepID=UPI0001792028
          Length = 1011

 Score =  142 bits (358), Expect = 1e-32
 Identities = 68/173 (39%), Positives = 104/173 (60%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L+ D+  KE F  NF  D+R  +   K  ++IT L  C+F  +  +      
Sbjct: 240 VATFYAKMLEHDYTTKEVFNKNFLKDWRKTMTP-KEKELITDLSLCNFKEMNVYF----T 294

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KK  E+KA +  E+K+ +E      +++    +DG +E +GNF++EPP LF GRG+HP  
Sbjct: 295 KKSEERKAMSKEEKKKIKEENEALQKEYGFCTIDGHKEKIGNFKIEPPGLFRGRGEHPKM 354

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +K+R+ PEDV +N   ++ IP+ P PGH W ++ H+  VTWLA W +++ G
Sbjct: 355 GMLKKRVVPEDVLINCSKDSNIPK-PPPGHKWKEVRHDFGVTWLASWIENVQG 406

[83][TOP]
>UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5C65
          Length = 755

 Score =  142 bits (358), Expect = 1e-32
 Identities = 71/173 (41%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  +    KA
Sbjct: 246 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KA 301

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A +KA T  E+ + +E     ++Q+   ++D  +E + NFR+EPP LF GRGDHP  
Sbjct: 302 QSEA-RKAMTKEEKLKIKEENERLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 360

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI+P+D+ +N   ++  PE P PG  W ++ H++ VTWL  W ++I G
Sbjct: 361 GMLKRRIRPQDIIINCSKDSKYPE-PPPGTKWKEVRHDNKVTWLVSWTENIQG 412

[84][TOP]
>UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU
          Length = 753

 Score =  142 bits (358), Expect = 1e-32
 Identities = 71/173 (41%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  +    KA
Sbjct: 244 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KA 299

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A +KA T  E+ + +E     ++Q+   ++D  +E + NFR+EPP LF GRGDHP  
Sbjct: 300 QSEA-RKAMTKEEKLKIKEENERLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 358

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI+P+D+ +N   ++  PE P PG  W ++ H++ VTWL  W ++I G
Sbjct: 359 GMLKRRIRPQDIIINCSKDSKYPE-PPPGTKWKEVRHDNKVTWLVSWTENIQG 410

[85][TOP]
>UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR
          Length = 881

 Score =  142 bits (358), Expect = 1e-32
 Identities = 78/181 (43%), Positives = 108/181 (59%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 156
           VA F+ S L  T HV    F+ NFF DF+ +L       D+K  KV I    KCDF  I 
Sbjct: 290 VAGFFGSMLNATQHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIF 349

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
           A+ +     K+ EKK    AE+K  +  +      +   + DGR++ VGNFRVEPP+LF 
Sbjct: 350 AYYD----MKRLEKKNLPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFR 405

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G +AP+P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 406 GRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 464

Query: 517 G 519
           G
Sbjct: 465 G 465

[86][TOP]
>UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HDT9_CHAGB
          Length = 907

 Score =  142 bits (358), Expect = 1e-32
 Identities = 79/181 (43%), Positives = 107/181 (59%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VATF+ S L  T +V    F+ NFFADF+ +L  T  AK        I   +K DF++I 
Sbjct: 312 VATFFGSMLHSTQNVENPVFQKNFFADFKDILKKTGGAKDKQGKPVDIKEFKKLDFTKIF 371

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            H +     +KA   A+  AE+ E  +AE      F     DGR+E VGNFRVEPP LF 
Sbjct: 372 DHYKALGDARKARPAAEKKAEKAEKDKAEGH----FMFCKWDGRKEKVGNFRVEPPGLFR 427

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG VK+R+ PE VT+N+G +A +P  P PGH W  + H++  TWLA W++++ 
Sbjct: 428 GRGEHPKTGTVKKRVMPEQVTINIGKDAKVP-APPPGHKWKAVQHDNKATWLAMWQENVN 486

Query: 517 G 519
           G
Sbjct: 487 G 487

[87][TOP]
>UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2
          Length = 745

 Score =  142 bits (358), Expect = 1e-32
 Identities = 72/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171
           VA F+A+ L++DH     F+ NFF DF  +L ++        I    +CDF+++  + + 
Sbjct: 160 VAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ- 218

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
               +K +KK  T+ E+K+ R    +    +    +DGR E VGNF+VEPP+LF GRG H
Sbjct: 219 ---LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAH 275

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           P TGK+KRR+ PED+ LNL  +AP+P  P  GH WG+I H++ V WLA W+++I
Sbjct: 276 PKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENI 328

[88][TOP]
>UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FTA8_NANOT
          Length = 896

 Score =  142 bits (358), Expect = 1e-32
 Identities = 75/181 (41%), Positives = 109/181 (60%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEK-FRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA+ + + L + H ++   F+ NFF DF+A++  T  AK        +    KCDF  I 
Sbjct: 305 VASHFGTMLNSTHNVENPVFQKNFFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVPIF 364

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            H E    K +A+KKA T AE+K A+  +      +   + DGR++ VGNFRVEPP LF 
Sbjct: 365 EHHE----KLRAQKKAMTAAEKKAAKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 420

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG VK R+QPE +T+N+G +AP+P  P  GH W ++ H+   TWLA W++++ 
Sbjct: 421 GRGEHPKTGTVKTRVQPEQITINIGKDAPVP-APPEGHRWKEVRHDQEGTWLAMWQENVN 479

Query: 517 G 519
           G
Sbjct: 480 G 480

[89][TOP]
>UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JVV4_UNCRE
          Length = 889

 Score =  142 bits (358), Expect = 1e-32
 Identities = 78/181 (43%), Positives = 105/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A++  T  AK        I   +KCDF  I 
Sbjct: 316 VAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIF 375

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E     K+ EKKA   AERK  +  +      +   + DGR++ VGNFRVEPP LF 
Sbjct: 376 EYYE----MKRLEKKALPAAERKRLKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 431

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P PGH W ++ H+   TWLA W+++I 
Sbjct: 432 GRGEHPKTGRVKTRVQPEQITINIGKGAAVPP-PPPGHKWKEVKHDQEGTWLAMWQENIN 490

Query: 517 G 519
           G
Sbjct: 491 G 491

[90][TOP]
>UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357
           RepID=B8MY66_ASPFN
          Length = 881

 Score =  142 bits (358), Expect = 1e-32
 Identities = 78/181 (43%), Positives = 108/181 (59%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 156
           VA F+ S L  T HV    F+ NFF DF+ +L       D+K  KV I    KCDF  I 
Sbjct: 290 VAGFFGSMLNATQHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIF 349

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
           A+ +     K+ EKK    AE+K  +  +      +   + DGR++ VGNFRVEPP+LF 
Sbjct: 350 AYYD----MKRLEKKNLPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFR 405

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G +AP+P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 406 GRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 464

Query: 517 G 519
           G
Sbjct: 465 G 465

[91][TOP]
>UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae
           RepID=B3LJ50_YEAS1
          Length = 769

 Score =  142 bits (358), Expect = 1e-32
 Identities = 72/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171
           VA F+A+ L++DH     F+ NFF DF  +L ++        I    +CDF+++  + + 
Sbjct: 184 VAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ- 242

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
               +K +KK  T+ E+K+ R    +    +    +DGR E VGNF+VEPP+LF GRG H
Sbjct: 243 ---LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAH 299

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           P TGK+KRR+ PED+ LNL  +AP+P  P  GH WG+I H++ V WLA W+++I
Sbjct: 300 PKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENI 352

[92][TOP]
>UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae
           RepID=TOP1_YEAST
          Length = 769

 Score =  142 bits (358), Expect = 1e-32
 Identities = 72/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171
           VA F+A+ L++DH     F+ NFF DF  +L ++        I    +CDF+++  + + 
Sbjct: 184 VAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ- 242

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
               +K +KK  T+ E+K+ R    +    +    +DGR E VGNF+VEPP+LF GRG H
Sbjct: 243 ---LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAH 299

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           P TGK+KRR+ PED+ LNL  +AP+P  P  GH WG+I H++ V WLA W+++I
Sbjct: 300 PKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENI 352

[93][TOP]
>UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL
          Length = 886

 Score =  142 bits (357), Expect = 2e-32
 Identities = 77/181 (42%), Positives = 106/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L  T HV    F+ NFF+DF+ +L  T  AK        I    KCDF  I 
Sbjct: 295 VAGFFGSMLNATQHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQSIF 354

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
           A+ +     K+ EK+    AE+K  +  +      +   L DGR++ VGNFRVEPP+LF 
Sbjct: 355 AYYD----AKRIEKRNIPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPSLFR 410

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  AP+P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 411 GRGEHPKTGRVKARVQPEQITINIGKGAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 469

Query: 517 G 519
           G
Sbjct: 470 G 470

[94][TOP]
>UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500
           RepID=B8MH68_TALSN
          Length = 864

 Score =  141 bits (356), Expect = 2e-32
 Identities = 76/181 (41%), Positives = 105/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF+A+L  T  AK        I    KCDF  I 
Sbjct: 273 VAGFFGSMLNSTHNVENPTFQKNFFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKPIF 332

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + +     K+ EKKA + AE+K  +  +      +   + DGR++ VGNFRVEPP LF 
Sbjct: 333 EYYD----AKRLEKKAMSAAEKKALKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPGLFR 388

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W++++ 
Sbjct: 389 GRGEHPKTGKVKTRVQPEQITINIGKEAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVN 447

Query: 517 G 519
           G
Sbjct: 448 G 448

[95][TOP]
>UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR
          Length = 767

 Score =  141 bits (356), Expect = 2e-32
 Identities = 66/173 (38%), Positives = 106/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   VIT+L KCDF+++  + +D+  
Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSE 316

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            +K   K     E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 317 ARKQMSKE----EKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 372

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424

[96][TOP]
>UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus
           RepID=TOP1M_RAT
          Length = 593

 Score =  141 bits (356), Expect = 2e-32
 Identities = 73/172 (42%), Positives = 105/172 (61%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY   L  +   KE FR NFF+D++  +   +  K+IT L+KCDFS I  H  +   
Sbjct: 85  VATFYGKMLHLECTTKEVFRRNFFSDWQKEMTAEE-RKLITHLDKCDFSEIHRHFME--- 140

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
             +AE +     E+K+  + EAE+++Q F   ++DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 141 --RAEARRTLPREQKQKLKEEAEKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 198

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRR+ PEDV +N   ++ IPE P  GH W ++  ++ V WLA W ++I
Sbjct: 199 MGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAWVENI 249

[97][TOP]
>UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG
          Length = 622

 Score =  141 bits (355), Expect = 3e-32
 Identities = 73/177 (41%), Positives = 104/177 (58%), Gaps = 4/177 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 168
           VA F+A  L  ++  K+ FR NFF D+R  + D +   +I  L+KCDF  I    +A +E
Sbjct: 82  VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 140

Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348
             K   K EK       RK  +EA  + + ++   L+D   E +GNF++EPP LF GRG+
Sbjct: 141 ARKNMSKEEKLVCNIQFRKVLKEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGE 200

Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           HP  GK+K+RIQPEDV +N    + IP  P  GH W ++ H++ VTWLA W ++I G
Sbjct: 201 HPKQGKLKKRIQPEDVIINCSKESRIP-VPPAGHRWKEVRHDNTVTWLASWTENIQG 256

[98][TOP]
>UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster
           RepID=Q8IR39_DROME
          Length = 581

 Score =  141 bits (355), Expect = 3e-32
 Identities = 67/172 (38%), Positives = 103/172 (59%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    KC+F  +  + + E  K
Sbjct: 89  ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 147

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 148 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 203

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G ++ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 204 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 254

[99][TOP]
>UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster
           RepID=Q494M1_DROME
          Length = 974

 Score =  141 bits (355), Expect = 3e-32
 Identities = 67/172 (38%), Positives = 103/172 (59%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    KC+F  +  + + E  K
Sbjct: 482 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 540

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 541 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 596

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G ++ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 597 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 647

[100][TOP]
>UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME
          Length = 581

 Score =  141 bits (355), Expect = 3e-32
 Identities = 67/172 (38%), Positives = 103/172 (59%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    KC+F  +  + + E  K
Sbjct: 89  ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 147

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 148 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 203

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G ++ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 204 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 254

[101][TOP]
>UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura
            RepID=B5DMS2_DROPS
          Length = 1054

 Score =  141 bits (355), Expect = 3e-32
 Identities = 69/173 (39%), Positives = 106/173 (61%), Gaps = 1/173 (0%)
 Frame = +1

Query: 4    ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
            ATFYA  L  D+  K+ F +NFF DFR  +  +K  ++I    KC+F  +  + + E   
Sbjct: 548  ATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE--- 603

Query: 184  KKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
              +EK+ Q T E K A++ E E  ++++   ++DG +E +GNFR+EPP LF GRG+HP  
Sbjct: 604  --SEKRKQATKEEKLAKKNENEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 661

Query: 361  GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI   DV++N G  + +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 662  GMIKRRIGASDVSINCGKESKVPP-PPPGSRWKEVRHDNTVTWLASWIENVQG 713

[102][TOP]
>UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE
          Length = 1042

 Score =  141 bits (355), Expect = 3e-32
 Identities = 69/173 (39%), Positives = 106/173 (61%), Gaps = 1/173 (0%)
 Frame = +1

Query: 4    ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
            ATFYA  L  D+  K+ F +NFF DFR  +  +K  ++I    KC+F  +  + + E   
Sbjct: 536  ATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE--- 591

Query: 184  KKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
              +EK+ Q T E K A++ E E  ++++   ++DG +E +GNFR+EPP LF GRG+HP  
Sbjct: 592  --SEKRKQATKEEKLAKKNENEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 649

Query: 361  GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI   DV++N G  + +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 650  GMIKRRIGASDVSINCGKESKVPP-PPPGSRWKEVRHDNTVTWLASWIENVQG 701

[103][TOP]
>UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus
           NAm1 RepID=A6R590_AJECN
          Length = 651

 Score =  141 bits (355), Expect = 3e-32
 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A + ++  AK        + S EKCDF  I 
Sbjct: 318 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIF 377

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E      + EKK+  +AE+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 378 EYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 433

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P PGH W +I H+   TWLA W++++ 
Sbjct: 434 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEIKHDQEGTWLAMWQENVN 492

Query: 517 G 519
           G
Sbjct: 493 G 493

[104][TOP]
>UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster
           RepID=TOP1_DROME
          Length = 972

 Score =  141 bits (355), Expect = 3e-32
 Identities = 67/172 (38%), Positives = 103/172 (59%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    KC+F  +  + + E  K
Sbjct: 480 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 538

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 539 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 594

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G ++ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 595 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 645

[105][TOP]
>UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus
           RepID=UPI0000ECD01B
          Length = 593

 Score =  140 bits (354), Expect = 4e-32
 Identities = 70/172 (40%), Positives = 107/172 (62%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +ATFYA  L  ++  KE F++NFF D+R  +   +  ++I  L+KCDF  I  +  D+  
Sbjct: 84  IATFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNE 142

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +KA  K     E K+  + EA+++++ +   ++DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 143 ARKALSK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 197

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +K+RI PEDV +N   ++ IPE PV GH W ++  ++ VTWLA W ++I
Sbjct: 198 MGMLKKRIMPEDVIINCSKDSKIPEPPV-GHKWKEVRFDNTVTWLASWTENI 248

[106][TOP]
>UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus
           RepID=Q6T722_CHICK
          Length = 593

 Score =  140 bits (354), Expect = 4e-32
 Identities = 70/172 (40%), Positives = 107/172 (62%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +ATFYA  L  ++  KE F++NFF D+R  +   +  ++I  L+KCDF  I  +  D+  
Sbjct: 84  IATFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNE 142

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +KA  K     E K+  + EA+++++ +   ++DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 143 ARKALSK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 197

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +K+RI PEDV +N   ++ IPE PV GH W ++  ++ VTWLA W ++I
Sbjct: 198 MGMLKKRIMPEDVIINCSKDSKIPEPPV-GHKWKEVRFDNTVTWLASWTENI 248

[107][TOP]
>UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA
          Length = 785

 Score =  140 bits (354), Expect = 4e-32
 Identities = 75/175 (42%), Positives = 107/175 (61%), Gaps = 3/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171
           VA F+A+ L++DHV    F+ NF  DF  +L +   A+    I    K DF++I  + + 
Sbjct: 200 VAGFFAAILESDHVKIPTFQKNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQV 259

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
           +K     +KK  +  E+K+ R  + E  + +    +DGR E VGNFR+EPP LF GRG H
Sbjct: 260 QKE----QKKQLSPQEKKQLRLEKEELEKPYKFCEIDGRVEQVGNFRIEPPGLFRGRGAH 315

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           P  GK+KRR+ PEDV LNL   APIPE P  GH WG+I H++ V WL+ W+++I+
Sbjct: 316 PKNGKLKRRVYPEDVVLNLDKEAPIPE-PPKGHKWGEIRHDNTVQWLSMWRENIS 369

[108][TOP]
>UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224
           RepID=B6QNQ2_PENMQ
          Length = 860

 Score =  140 bits (354), Expect = 4e-32
 Identities = 76/181 (41%), Positives = 108/181 (59%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VA F+ + L + H V    F+ NFF DF+A+L  T  AK        I   +KCDF  I 
Sbjct: 269 VAGFFGAMLNSTHNVENPTFQKNFFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIF 328

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E ++ +KK    A+  A + E  EAEA     +   + DGR++ VGNFRVEPP+LF 
Sbjct: 329 EYYEGKRLEKKNLSAAEKKALKAERDEAEAP----YMYCIWDGRKQKVGNFRVEPPSLFR 384

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G +A +P  P  GH W ++ H+   TWLA W++++ 
Sbjct: 385 GRGEHPKTGKVKTRVMPEQITINIGKDAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVN 443

Query: 517 G 519
           G
Sbjct: 444 G 444

[109][TOP]
>UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans
           RepID=O17966-2
          Length = 734

 Score =  140 bits (354), Expect = 4e-32
 Identities = 70/173 (40%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +A FYA  L  ++  KE F  NF  D+R ++   +  + I  L+KCDF  I+A+ ++++ 
Sbjct: 226 IAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQRE 284

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            +KA  K +   + KE +EAE   V+ + +A++DG  + V NFR+EPP +F GRG HP  
Sbjct: 285 IRKAMTKEEKL-KIKEEKEAE---VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKM 340

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +K+RI PEDV +N G +  IP+ P PGH W ++ H++ VTWL  W +S+ G
Sbjct: 341 GLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVRHDNTVTWLCSWTESVLG 392

[110][TOP]
>UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL
          Length = 806

 Score =  140 bits (354), Expect = 4e-32
 Identities = 70/173 (40%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +A FYA  L  ++  KE F  NF  D+R ++   +  + I  L+KCDF  I+A+ ++++ 
Sbjct: 298 IAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQRE 356

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            +KA  K +   + KE +EAE   V+ + +A++DG  + V NFR+EPP +F GRG HP  
Sbjct: 357 IRKAMTKEEKL-KIKEEKEAE---VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKM 412

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +K+RI PEDV +N G +  IP+ P PGH W ++ H++ VTWL  W +S+ G
Sbjct: 413 GLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVRHDNTVTWLCSWTESVLG 464

[111][TOP]
>UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI
          Length = 997

 Score =  140 bits (353), Expect = 5e-32
 Identities = 66/172 (38%), Positives = 103/172 (59%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  K+ F +NFF DFR  + D +  ++I    KC+F  +    + E  +
Sbjct: 491 ATFYAKMLNHDYCTKDVFNTNFFKDFRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAESER 549

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +  A++ E        V+++   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 550 RKAATKDEKLAKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 605

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRI   +V++N G N+ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 606 MIKRRIGASEVSINCGKNSKVP-TPPPGQRWKEVRHDNTVTWLASWVENVQG 656

[112][TOP]
>UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER
          Length = 969

 Score =  140 bits (353), Expect = 5e-32
 Identities = 68/172 (39%), Positives = 102/172 (59%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +  +K  ++I    KC F+ +    + E  K
Sbjct: 477 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFNEMFNFFQAESEK 535

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 536 RKAATKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 591

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G  + +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 592 MIKRRIQASDVSINCGKESKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 642

[113][TOP]
>UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143
           RepID=C6HAF8_AJECH
          Length = 909

 Score =  140 bits (353), Expect = 5e-32
 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A + ++  AK        I S +KCDF  I 
Sbjct: 318 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIF 377

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E      + EKK+  +AE+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 378 EYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 433

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P PGH W ++ H+   TWLA W+++I 
Sbjct: 434 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENIN 492

Query: 517 G 519
           G
Sbjct: 493 G 493

[114][TOP]
>UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR
           RepID=C0NC53_AJECG
          Length = 909

 Score =  140 bits (353), Expect = 5e-32
 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A + ++  AK        I S +KCDF  I 
Sbjct: 318 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIF 377

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E      + EKK+  +AE+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 378 EYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 433

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P PGH W ++ H+   TWLA W+++I 
Sbjct: 434 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENIN 492

Query: 517 G 519
           G
Sbjct: 493 G 493

[115][TOP]
>UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum
           RepID=Q9Y180_LEIIN
          Length = 635

 Score =  140 bits (352), Expect = 7e-32
 Identities = 83/177 (46%), Positives = 105/177 (59%), Gaps = 4/177 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---E 168
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I + HL   E
Sbjct: 83  VATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQRE 140

Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348
            + ++ K EKKA      KE ++AEAE  R     + DGR E V NFRVEPP LF GRG 
Sbjct: 141 KKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGK 192

Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           HPL GK+K R+QPED+T+N+G  A +P  P  GH W  + H+  VTWLA W+DS+ G
Sbjct: 193 HPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAG 248

[116][TOP]
>UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani
           RepID=Q9NJG8_LEIDO
          Length = 949

 Score =  140 bits (352), Expect = 7e-32
 Identities = 83/177 (46%), Positives = 105/177 (59%), Gaps = 4/177 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---E 168
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I + HL   E
Sbjct: 398 VATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQRE 455

Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348
            + ++ K EKKA      KE ++AEAE  R     + DGR E V NFRVEPP LF GRG 
Sbjct: 456 KKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGK 507

Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           HPL GK+K R+QPED+T+N+G  A +P  P  GH W  + H+  VTWLA W+DS+ G
Sbjct: 508 HPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAG 563

[117][TOP]
>UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN
          Length = 635

 Score =  140 bits (352), Expect = 7e-32
 Identities = 83/177 (46%), Positives = 105/177 (59%), Gaps = 4/177 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---E 168
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I + HL   E
Sbjct: 83  VATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQRE 140

Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348
            + ++ K EKKA      KE ++AEAE  R     + DGR E V NFRVEPP LF GRG 
Sbjct: 141 KKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGK 192

Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           HPL GK+K R+QPED+T+N+G  A +P  P  GH W  + H+  VTWLA W+DS+ G
Sbjct: 193 HPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAG 248

[118][TOP]
>UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei
           RepID=Q581U8_9TRYP
          Length = 661

 Score =  140 bits (352), Expect = 7e-32
 Identities = 75/173 (43%), Positives = 101/173 (58%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDFS I    + E  
Sbjct: 111 VATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVE 168

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K+K+    +T  E+KE +    E    +   + +G++E V NFRVEPP LF GRG+HP+ 
Sbjct: 169 KRKS----RTREEKKELKRIADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMR 224

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           GK+K+RI PEDV LN+G  APIP+ P  GH W  ++H+  VTWLA W +   G
Sbjct: 225 GKLKKRILPEDVVLNIGKEAPIPQAPA-GHKWKGVVHDQNVTWLAMWYEPTIG 276

[119][TOP]
>UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma
           cruzi RepID=Q4DTW1_TRYCR
          Length = 664

 Score =  140 bits (352), Expect = 7e-32
 Identities = 77/175 (44%), Positives = 106/175 (60%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A   + D+   E FR NFF+ +R +L   K    I  LE CDF  I + HL +  
Sbjct: 86  VATMFAVMREHDYYRNEIFRRNFFSSWREIL--DKRQHPIRRLELCDFEPIYQWHLRER- 142

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
                EKK   T E K+    EAE+  + +   + DG++E V NFRVEPP LF GRG HP
Sbjct: 143 -----EKKLSRTKEEKKQLRLEAEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHP 197

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           + GK+K+R++PED+T+N+   +PIP+ P  GH W +++H   VTWLA W+DSI G
Sbjct: 198 MMGKLKKRVEPEDITINIDEFSPIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILG 251

[120][TOP]
>UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma
           brucei RepID=C9ZLY6_TRYBG
          Length = 696

 Score =  140 bits (352), Expect = 7e-32
 Identities = 75/173 (43%), Positives = 101/173 (58%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDFS I    + E  
Sbjct: 146 VATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVE 203

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K+K+    +T  E+KE +    E    +   + +G++E V NFRVEPP LF GRG+HP+ 
Sbjct: 204 KRKS----RTREEKKELKRIADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMR 259

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           GK+K+RI PEDV LN+G  APIP+ P  GH W  ++H+  VTWLA W +   G
Sbjct: 260 GKLKKRILPEDVVLNIGKEAPIPQAPA-GHKWKGVVHDQNVTWLAMWYEPTIG 311

[121][TOP]
>UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA
          Length = 580

 Score =  140 bits (352), Expect = 7e-32
 Identities = 68/172 (39%), Positives = 101/172 (58%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +  +K  ++I    KC F  +    + E  K
Sbjct: 88  ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEK 146

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 147 RKAATKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 202

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRIQ  DV++N G  + +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 203 MIKRRIQASDVSINCGKESKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 253

[122][TOP]
>UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I,
           mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens
           RepID=B7ZAR5_HUMAN
          Length = 503

 Score =  140 bits (352), Expect = 7e-32
 Identities = 71/164 (43%), Positives = 105/164 (64%), Gaps = 1/164 (0%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L  ++  KE FR NFF+D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   + 
Sbjct: 2   LDHEYTTKEVFRKNFFSDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59

Query: 205 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 381
               E K+  + EAE+++Q F   ++DG +E +GNF++EPP LF GRGDHP  G +KRRI
Sbjct: 60  ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115

Query: 382 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +S+
Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 158

[123][TOP]
>UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735
           delta SOWgp RepID=C5P0Y8_COCP7
          Length = 905

 Score =  140 bits (352), Expect = 7e-32
 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A++  T  AK       +I   +KCDF  I 
Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIF 373

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E     K+ EKKA   AERK  +  +      +   + DGR++ VGNFRVEPP LF 
Sbjct: 374 EYYE----MKREEKKALPAAERKRLKVEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 429

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 430 GRGEHPKTGRVKTRVQPEQITINIGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENIN 488

Query: 517 G 519
           G
Sbjct: 489 G 489

[124][TOP]
>UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1D4R5_NEOFI
          Length = 886

 Score =  140 bits (352), Expect = 7e-32
 Identities = 78/181 (43%), Positives = 104/181 (57%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L  T HV    F+ NFF DF+ +L  T  AK        I    KCDF  I 
Sbjct: 295 VAGFFGSMLNATQHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRPIF 354

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E     K+ EKK    AE+K  +  +      +   L DGR++ VGNFRVEPP LF 
Sbjct: 355 DYYE----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFR 410

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G +AP+P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 411 GRGEHPKTGRVKARVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 469

Query: 517 G 519
           G
Sbjct: 470 G 470

[125][TOP]
>UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata
           RepID=UPI000194D872
          Length = 775

 Score =  139 bits (351), Expect = 9e-32
 Identities = 69/174 (39%), Positives = 106/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  +   +    ITSL KCDF+ +  +      
Sbjct: 266 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF----- 319

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + E ER+ +++   ++D  +E + NF++EPP LF GRG+HP 
Sbjct: 320 KAQSEARKQMSKEEKQKIKEENERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPK 379

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI PED+ +N   ++ IP  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 380 MGMLKRRIMPEDIIINCSKDSKIP-APPPGHKWKEVRHDNKVTWLVSWTENIQG 432

[126][TOP]
>UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra
           magnipapillata RepID=UPI000192545C
          Length = 726

 Score =  139 bits (351), Expect = 9e-32
 Identities = 72/174 (41%), Positives = 106/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L  D+V K+ F  NFF D+R  +   +   +I SL+KCDF  + A+      
Sbjct: 205 VATFYAKMLDHDYVKKDIFNENFFEDWRKEMTAEE-RNIIKSLDKCDFKEMHAYF----- 258

Query: 181 KKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            K AE+K   T E K+A +EA  +   ++    +DG ++ VGNFR+EPP LF GRGDHP 
Sbjct: 259 MKCAEEKRNMTKEEKQAIKEANLKIAEKYGFCEMDGHKQKVGNFRIEPPGLFRGRGDHPK 318

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            GK+K+R+  ++V +N+G  A +P+ P  G  W  + H++ V+WLA W ++I G
Sbjct: 319 QGKLKKRVSAKEVIINIGKEAKVPQ-PPEGQKWKAVQHDNTVSWLACWVENIAG 371

[127][TOP]
>UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus
           caballus RepID=UPI0001797824
          Length = 765

 Score =  139 bits (351), Expect = 9e-32
 Identities = 67/173 (38%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +ITSL KCDF+++  +    KA
Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF---KA 311

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 312 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 370

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422

[128][TOP]
>UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta
           RepID=UPI00006D45A8
          Length = 767

 Score =  139 bits (351), Expect = 9e-32
 Identities = 66/173 (38%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 313

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D  +E + NF++EPP LF GRG+HP  
Sbjct: 314 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 372

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424

[129][TOP]
>UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA
          Length = 560

 Score =  139 bits (351), Expect = 9e-32
 Identities = 66/173 (38%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 51  VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 106

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D  +E + NF++EPP LF GRG+HP  
Sbjct: 107 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 165

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 166 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 217

[130][TOP]
>UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis
           RepID=Q1DXZ1_COCIM
          Length = 905

 Score =  139 bits (351), Expect = 9e-32
 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A++  T  AK       +I   +KCDF  I 
Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIF 373

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E     K+ EKKA   AERK  +  +      +   + DGR++ VGNFRVEPP LF 
Sbjct: 374 EYYE----MKREEKKALPAAERKRLKAEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 429

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 430 GRGEHPKTGRVKIRVQPEQITINIGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENIN 488

Query: 517 G 519
           G
Sbjct: 489 G 489

[131][TOP]
>UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus
           scrofa RepID=UPI00017EFDA4
          Length = 748

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/173 (38%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 240 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 295

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 296 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKM 354

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 355 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 406

[132][TOP]
>UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1DB6
          Length = 770

 Score =  139 bits (350), Expect = 1e-31
 Identities = 71/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +     +E  
Sbjct: 261 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYF 314

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + E ER+ Q +   ++D  +E +GNFR+EPP LF GRGDHP 
Sbjct: 315 KAQSEARKQMSKEEKQKIKEENERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 374

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G
Sbjct: 375 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 427

[133][TOP]
>UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A48
          Length = 632

 Score =  139 bits (350), Expect = 1e-31
 Identities = 73/173 (42%), Positives = 102/173 (58%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA F+A  L  ++  K+ FR NFF D+R  + D +   +I  L KCDF  I A     KA
Sbjct: 122 VALFFAQMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKA 177

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K +A K   T  E++  +EA  + V +F   L+D   E +GNF++EPP LF GRG+HP  
Sbjct: 178 KVEARKN-MTKEEKQALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQ 236

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +K+RIQPED+ +N    A IP  P  GH W ++ H++ VTWL  W ++I G
Sbjct: 237 GMLKKRIQPEDIIINCSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTENIQG 288

[134][TOP]
>UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG
          Length = 783

 Score =  139 bits (350), Expect = 1e-31
 Identities = 71/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +     +E  
Sbjct: 242 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYF 295

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + E ER+ Q +   ++D  +E +GNFR+EPP LF GRGDHP 
Sbjct: 296 KAQSEARKQMSKEEKQKIKEENERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 355

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G
Sbjct: 356 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 408

[135][TOP]
>UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI
          Length = 1045

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/172 (38%), Positives = 101/172 (58%)
 Frame = +1

Query: 4    ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
            ATFYA  L  D+  K+ F +NFF DFR  +   K  ++I    KC+F  +      E  K
Sbjct: 539  ATFYAKMLNHDYCTKDVFNNNFFKDFRKSMTP-KEKEIIKDFRKCNFQEMHQFFLAESEK 597

Query: 184  KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
            +KA  K +  A++ E        ++++   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 598  RKAATKEEKLAKKNENEAL----IKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 653

Query: 364  KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             +KRRI   DV++N G  + +P+ P PG  W ++ H++ VTWLA W +++ G
Sbjct: 654  MIKRRIAAADVSINCGKQSKVPQ-PPPGERWKEVRHDNTVTWLASWTENVQG 704

[136][TOP]
>UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16
           RepID=A8XXL4_CAEBR
          Length = 840

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/172 (38%), Positives = 110/172 (63%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  +  ++  + +F +NF  D+R L+   +  K IT L KCDF+    H+ + + +
Sbjct: 318 ATFYAGVVNHEYSSQVQFNTNFMKDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNE 372

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           ++  +KA T  E+ + +E +A+ V  + +A++DG +E + NFR+EPP +F GRG HP  G
Sbjct: 373 QREIRKAMTKEEKAKIKEEKAQEVVDYGIAIIDGHKEKIANFRIEPPGVFRGRGGHPKMG 432

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +K+RI PEDV +N G ++ IP+ P+ GH W ++ H++ V+WL  W +S+ G
Sbjct: 433 FIKKRIVPEDVIVNCGKDSVIPKPPL-GHKWKEVRHDNTVSWLCSWTESVLG 483

[137][TOP]
>UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN
          Length = 765

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/173 (38%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 311

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D  +E + NF++EPP LF GRG+HP  
Sbjct: 312 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 370

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422

[138][TOP]
>UniRef100_B4DYD2 cDNA FLJ50294, highly similar to DNA topoisomerase I, mitochondrial
           (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4DYD2_HUMAN
          Length = 503

 Score =  139 bits (350), Expect = 1e-31
 Identities = 72/164 (43%), Positives = 104/164 (63%), Gaps = 1/164 (0%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L  ++  KE FR NFF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   + 
Sbjct: 2   LDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59

Query: 205 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 381
               E K+  + EAE+++Q F   ++DG +E +GNF++EPP LF GRGDHP  G +KRRI
Sbjct: 60  ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115

Query: 382 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +SI
Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESI 158

[139][TOP]
>UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN
          Length = 765

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/173 (38%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 311

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D  +E + NF++EPP LF GRG+HP  
Sbjct: 312 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 370

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422

[140][TOP]
>UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE
          Length = 767

 Score =  139 bits (350), Expect = 1e-31
 Identities = 66/173 (38%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 313

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D  +E + NF++EPP LF GRG+HP  
Sbjct: 314 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 372

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424

[141][TOP]
>UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus
           RepID=TOP1M_MOUSE
          Length = 593

 Score =  139 bits (350), Expect = 1e-31
 Identities = 72/172 (41%), Positives = 104/172 (60%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY   L  +   KE FR NFF+D+R  +   +  ++IT L+KCDF+ I  H  +   
Sbjct: 85  VATFYGKMLHLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE--- 140

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
             +AE +     E+K+  + EAE+++Q F   ++DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 141 --RAEARRTLPREQKQKLKEEAEKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPK 198

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRR+ PEDV +N   ++ IPE P  GH W ++  ++ V WLA W + I
Sbjct: 199 MGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAWVEHI 249

[142][TOP]
>UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155C8C4
          Length = 781

 Score =  139 bits (349), Expect = 2e-31
 Identities = 66/173 (38%), Positives = 109/173 (63%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  + + + +  IT+L KCDF+ +  +    KA
Sbjct: 272 VATFFAKMLDHEYTTKDIFRKNFFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF---KA 327

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+++ +E   + ++++   ++D   E + NFR+EPP LF GRG+HP  
Sbjct: 328 QSEARKQ-MSKEEKQKIKEENEQLLKEYGFCVMDNHRERIANFRIEPPGLFRGRGNHPKM 386

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRIQPED+ +N   ++ +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 387 GMLKRRIQPEDIIINCSKDSKVPP-PPPGHRWKEVRHDNKVTWLVSWTENIQG 438

[143][TOP]
>UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1
           Tax=Ornithorhynchus anatinus RepID=UPI0001555600
          Length = 689

 Score =  139 bits (349), Expect = 2e-31
 Identities = 70/172 (40%), Positives = 106/172 (61%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +ATFY   L  ++  K+ F++NFF+D+R  +   +  K I  LE+CDF+ I  +  D+  
Sbjct: 180 IATFYGKMLDHEYTTKDIFQNNFFSDWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNE 238

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +KA  K     E K+  + EAE++++ F   ++DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 239 ARKALPK-----EEKQKLKEEAEKLQEEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 293

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +K+RI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W ++I
Sbjct: 294 MGLLKKRIMPEDVIINCSKDSKIPE-PPSGHKWKEVRFDNTVTWLASWTENI 344

[144][TOP]
>UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1
           RepID=UPI000023DEFB
          Length = 910

 Score =  139 bits (349), Expect = 2e-31
 Identities = 78/184 (42%), Positives = 109/184 (59%), Gaps = 13/184 (7%)
 Frame = +1

Query: 1   VATFYASKLQT---DHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 153
           VATF+ + +      H+    FR NFF DF+       + D +  KV I SL+KC+F +I
Sbjct: 309 VATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFDKI 368

Query: 154 EAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEP 321
             +    +E  K K   +++ +    +K+A EA       FT    DGR+E VGNFRVEP
Sbjct: 369 NDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEAP------FTHCTWDGRKEKVGNFRVEP 422

Query: 322 PNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 501
           P+LF GRG+HP TGKVK+R+QPE +T+N+G  A IPE P  GH W  + H+   TWLA W
Sbjct: 423 PSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMW 481

Query: 502 KDSI 513
           +++I
Sbjct: 482 QENI 485

[145][TOP]
>UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR
          Length = 664

 Score =  139 bits (349), Expect = 2e-31
 Identities = 76/175 (43%), Positives = 106/175 (60%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177
           VAT +A   + D+   E FR NFF+ +R +L   +    I  LE CDF  I + HL +  
Sbjct: 86  VATMFAVMREHDYYRNEIFRRNFFSSWREILDRRQHP--IRRLELCDFEPIYQWHLRER- 142

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
                EKK   T E K+    EAE+  + +   + DG++E V NFRVEPP LF GRG HP
Sbjct: 143 -----EKKLSRTKEEKKQLRLEAEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHP 197

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           + GK+K+R++PED+T+N+   +PIP+ P  GH W +++H   VTWLA W+DSI G
Sbjct: 198 MMGKLKKRVEPEDITINIDEFSPIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILG 251

[146][TOP]
>UniRef100_B7Z9E8 cDNA, FLJ78812, highly similar to DNA topoisomerase I,
           mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens
           RepID=B7Z9E8_HUMAN
          Length = 503

 Score =  139 bits (349), Expect = 2e-31
 Identities = 71/164 (43%), Positives = 104/164 (63%), Gaps = 1/164 (0%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L  ++  KE FR NFF D+R  +A  +  +VI SL+KCDF+ I  +  D+ A +K   + 
Sbjct: 2   LDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59

Query: 205 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 381
               E K+  + EAE+++Q F   ++DG +E +GNF++EPP LF GRGDHP  G +KRRI
Sbjct: 60  ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115

Query: 382 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +S+
Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 158

[147][TOP]
>UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU
          Length = 909

 Score =  139 bits (349), Expect = 2e-31
 Identities = 78/184 (42%), Positives = 109/184 (59%), Gaps = 13/184 (7%)
 Frame = +1

Query: 1   VATFYASKLQT---DHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 153
           VATF+ + +      H+    FR NFF DF+       + D +  KV I SL+KC+F +I
Sbjct: 308 VATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKI 367

Query: 154 EAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEP 321
             +    +E  K K   +++ +    +K+A EA       FT    DGR+E VGNFRVEP
Sbjct: 368 NDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEAP------FTHCTWDGRKEKVGNFRVEP 421

Query: 322 PNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 501
           P+LF GRG+HP TGKVK+R+QPE +T+N+G  A IPE P  GH W  + H+   TWLA W
Sbjct: 422 PSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMW 480

Query: 502 KDSI 513
           +++I
Sbjct: 481 QENI 484

[148][TOP]
>UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC
          Length = 998

 Score =  139 bits (349), Expect = 2e-31
 Identities = 77/181 (42%), Positives = 104/181 (57%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L  T HV    F+ NFF DF+ +L  T  AK        I    KCDF  I 
Sbjct: 407 VAGFFGSMLNATQHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRPIF 466

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + +     K+ EKK    AE+K  +  +      +   L DGR++ VGNFRVEPP LF 
Sbjct: 467 DYYD----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFR 522

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G +AP+P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 523 GRGEHPKTGRVKARVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 581

Query: 517 G 519
           G
Sbjct: 582 G 582

[149][TOP]
>UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus
           RepID=UPI00006154BF
          Length = 769

 Score =  138 bits (348), Expect = 2e-31
 Identities = 66/173 (38%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 260 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 315

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 316 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 374

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 375 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 426

[150][TOP]
>UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK
          Length = 766

 Score =  138 bits (348), Expect = 2e-31
 Identities = 68/174 (39%), Positives = 105/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  +   +    ITSL KCDF+ +  +      
Sbjct: 257 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF----- 310

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K + E + Q + E K+  + E ER+ +++   ++D  +E + NF++EPP LF GRG+HP 
Sbjct: 311 KAQTEARKQMSKEEKQKIKEENERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPK 370

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI PED+ +N   ++ +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 371 MGMLKRRIMPEDIIINCSKDSKVPP-PPPGHKWKEVRHDNKVTWLVSWTENIQG 423

[151][TOP]
>UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major
           RepID=Q4Q2K0_LEIMA
          Length = 634

 Score =  138 bits (348), Expect = 2e-31
 Identities = 78/173 (45%), Positives = 101/173 (58%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I      ++ 
Sbjct: 83  VATMFAVMKEHDYYRMEVFRRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQRE 140

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KK +  K +  A  KE ++AEAE  R     + DGR E V NFRVEPP LF GRG HPL 
Sbjct: 141 KKLSRTKEEKKAI-KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLM 196

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           GK+K R+QPED+T+N+G  A +P  P  GH W  + H+  VTWLA W+D++ G
Sbjct: 197 GKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDNVAG 248

[152][TOP]
>UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE
          Length = 970

 Score =  138 bits (348), Expect = 2e-31
 Identities = 66/172 (38%), Positives = 101/172 (58%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    KC F  +  + + E  K
Sbjct: 478 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCGFQEMFNYFQAESEK 536

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           +KA  K +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 537 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 592

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRRI   DV++N G ++ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 593 MIKRRIHASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 643

[153][TOP]
>UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
           RepID=C7YQG7_NECH7
          Length = 919

 Score =  138 bits (348), Expect = 2e-31
 Identities = 78/181 (43%), Positives = 109/181 (60%), Gaps = 10/181 (5%)
 Frame = +1

Query: 1   VATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 153
           VATF+ + +    + H+    FR NFF DF+       + D    KV I SL+KCDF+++
Sbjct: 318 VATFWVAMMTPASSHHMENPVFRKNFFEDFQEYCKKYGVTDADGKKVQIKSLDKCDFTKL 377

Query: 154 EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNL 330
             +     AK +  K    T E KEA +A+ E +   FT  + DGR++ VGNFRVEPP+L
Sbjct: 378 ADYW---LAKAEQNKTKNMTKEEKEAAKAKKEALEAPFTHCMWDGRKQKVGNFRVEPPSL 434

Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDS 510
           F GRG+HP TGKVK R+ PE +T+N+G  A IP+ P  GH W  + H+   TWLA W+++
Sbjct: 435 FRGRGEHPKTGKVKNRVTPEQITINIGKGAKIPD-PPKGHQWKAVQHDQKATWLAMWQEN 493

Query: 511 I 513
           I
Sbjct: 494 I 494

[154][TOP]
>UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus
           norvegicus RepID=UPI0001B7BF13
          Length = 760

 Score =  138 bits (347), Expect = 3e-31
 Identities = 66/173 (38%), Positives = 108/173 (62%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +    KA
Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 311

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D  +E + NF++EPP LF GRG+HP  
Sbjct: 312 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHKERIANFKIEPPGLFRGRGNHPKM 370

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422

[155][TOP]
>UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE
          Length = 592

 Score =  138 bits (347), Expect = 3e-31
 Identities = 73/172 (42%), Positives = 105/172 (61%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY   L  +   KE FR NFF+D+R  +   +  ++IT L+KCDF+ I  H  +   
Sbjct: 85  VATFYGKMLHLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE--- 140

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
             +AE +     E+K+ +E EAE+++Q F   ++DG  E +GNF+ EPP LF GRGDHP 
Sbjct: 141 --RAEARRTLPREQKQLKE-EAEKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPK 197

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +KRR+ PEDV +N   ++ IPE P  GH W ++  ++ V WLA W + I
Sbjct: 198 MGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAWVEHI 248

[156][TOP]
>UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis
           RepID=A4HB62_LEIBR
          Length = 637

 Score =  138 bits (347), Expect = 3e-31
 Identities = 75/173 (43%), Positives = 97/173 (56%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I      E+ 
Sbjct: 83  VATMFAVMKEHDYYRMEAFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWYLAERE 140

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KK      +T  E+K  +E +      +   + DGR E V NFRVEPP LF GRG HPL 
Sbjct: 141 KKLN----RTKEEKKSIKEKQDMDAEPYRYCMWDGRREQVANFRVEPPGLFRGRGKHPLM 196

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           GK+K R+QPE +T+N+G  A +P  P  GH WG + H+  VTWLA W+DS+ G
Sbjct: 197 GKLKARVQPEGITINIGETAEVP-VPPAGHKWGAVQHDHTVTWLAMWRDSVVG 248

[157][TOP]
>UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2
           Tax=Emericella nidulans RepID=C8VUK1_EMENI
          Length = 871

 Score =  138 bits (347), Expect = 3e-31
 Identities = 75/181 (41%), Positives = 105/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VA F+ S L  T H     F+ NFFADF+ +L  T  AK        I    KCDF  I 
Sbjct: 280 VAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIF 339

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + + ++     EKKA   AE+K  +  +  +   +   + DGR++ VGNFRVEPP+LF 
Sbjct: 340 QYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFR 395

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 396 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 454

Query: 517 G 519
           G
Sbjct: 455 G 455

[158][TOP]
>UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA
          Length = 829

 Score =  138 bits (347), Expect = 3e-31
 Identities = 70/174 (40%), Positives = 105/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D++  +  T    +IT+L KCDF+ +  +      
Sbjct: 312 VATFFAKMLDHEYTTKDIFRKNFFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF----- 365

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K+++E +   T E K   +AE ER+ Q +   ++D  +E + NFR+EPP LF GRGDHP 
Sbjct: 366 KEQSEARKNMTKEEKLKIKAENERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDHPK 425

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            GK+K+RI PED+ +N   ++ IP  P  GH W ++ H+  VTWL  W ++I G
Sbjct: 426 MGKLKKRIMPEDIIINCSKDSKIPVAPA-GHKWKEVRHDGKVTWLVSWTENIQG 478

[159][TOP]
>UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0
          Length = 758

 Score =  137 bits (346), Expect = 3e-31
 Identities = 66/173 (38%), Positives = 107/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +    KA
Sbjct: 249 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 304

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 305 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 363

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 364 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 415

[160][TOP]
>UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT
          Length = 767

 Score =  137 bits (346), Expect = 3e-31
 Identities = 66/173 (38%), Positives = 107/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +    KA
Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 313

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 314 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 372

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424

[161][TOP]
>UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE
          Length = 767

 Score =  137 bits (346), Expect = 3e-31
 Identities = 66/173 (38%), Positives = 107/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +    KA
Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 313

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 314 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 372

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424

[162][TOP]
>UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5FAF
          Length = 573

 Score =  137 bits (345), Expect = 4e-31
 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +     +E  
Sbjct: 64  VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYF 117

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + + ER+ Q +   ++D  +E +GNFR+EPP LF GRGDHP 
Sbjct: 118 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 177

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G
Sbjct: 178 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 230

[163][TOP]
>UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F97
          Length = 790

 Score =  137 bits (345), Expect = 4e-31
 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +     +E  
Sbjct: 296 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYF 349

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + + ER+ Q +   ++D  +E +GNFR+EPP LF GRGDHP 
Sbjct: 350 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 409

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G
Sbjct: 410 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 462

[164][TOP]
>UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F96
          Length = 767

 Score =  137 bits (345), Expect = 4e-31
 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +     +E  
Sbjct: 258 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYF 311

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + + ER+ Q +   ++D  +E +GNFR+EPP LF GRGDHP 
Sbjct: 312 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 371

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G
Sbjct: 372 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 424

[165][TOP]
>UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624
           RepID=Q0CUT4_ASPTN
          Length = 872

 Score =  137 bits (345), Expect = 4e-31
 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 156
           VA F+ S L  T H     F+ NFF DF+ +L       D K  KV I   +KCDF  I 
Sbjct: 281 VAGFFGSMLNSTQHTENPTFQKNFFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIF 340

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E     K+ EK+    AE+K  +  + E+   +   + DGR++ VGNFRVEPP+LF 
Sbjct: 341 DYYE----AKRIEKRNLPAAEKKRLKAEKDEQEAPYMYCMWDGRKQKVGNFRVEPPSLFR 396

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 397 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 455

Query: 517 G 519
           G
Sbjct: 456 G 456

[166][TOP]
>UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin
           54-1255 RepID=B6H1W4_PENCW
          Length = 864

 Score =  137 bits (345), Expect = 4e-31
 Identities = 73/181 (40%), Positives = 112/181 (61%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEK-FRSNFFADFRALLA------DTKFAKV-ITSLEKCDFSRIE 156
           VA+F+ + L + H ++   F+ NFF+DF+ ++       D+K  KV I    KCDF  I 
Sbjct: 272 VASFFGTMLNSTHNVENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIF 331

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
              + ++     EK+    AE+K A+  + E+   +   + DGR++ VGNFRVEPP+LF 
Sbjct: 332 EFYDAQRE----EKRHLPPAEKKAAKALKDEQEAPYQYCIWDGRKQKVGNFRVEPPSLFR 387

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G +A +P  P PGH W ++ H+   TWLA W+++I 
Sbjct: 388 GRGEHPKTGRVKTRVQPEQITINIGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENIN 446

Query: 517 G 519
           G
Sbjct: 447 G 447

[167][TOP]
>UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI
          Length = 871

 Score =  137 bits (344), Expect = 6e-31
 Identities = 75/181 (41%), Positives = 104/181 (57%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VA F+ S L  T H     F+ NFFADF+ +L  T  AK        I    KCDF  I 
Sbjct: 280 VAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIF 339

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + + ++     EKKA   AE+K  +  +  +   +   + DGR++ VGNFRVEPP LF 
Sbjct: 340 QYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPPLFR 395

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 396 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 454

Query: 517 G 519
           G
Sbjct: 455 G 455

[168][TOP]
>UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio
           RepID=UPI000176075D
          Length = 531

 Score =  136 bits (343), Expect = 8e-31
 Identities = 69/174 (39%), Positives = 105/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEK 177
           VA ++A  L  ++  KE FR+NFF D+R  +   +  ++I  L+KCDF  + A H E  +
Sbjct: 22  VALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVE 80

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           A+K   K+     E+   +EA  + V ++   ++D   E +GNF++EPP LF GRGDHP 
Sbjct: 81  ARKNLSKE-----EKLVNKEANQKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPK 135

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +K+RI+PEDV +N    + IPE P  GH W ++ H+  VTWLA W +++ G
Sbjct: 136 QGMLKKRIRPEDVIINCSKESRIPEAPA-GHKWKEVRHDKTVTWLASWTENVQG 188

[169][TOP]
>UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica
           RepID=UPI0000F2B3E5
          Length = 916

 Score =  136 bits (343), Expect = 8e-31
 Identities = 68/174 (39%), Positives = 106/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  + + +    IT+L KCDF++I  +      
Sbjct: 407 VATFFAKMLDHEYTTKDIFRKNFFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF----- 460

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K   + E ER+ +++   ++D   E + NF++EPP LF GRG+HP 
Sbjct: 461 KAQSEARKQMSKEEKLKIKEENERLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPK 520

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI PED+ +N   +A +P  P PGH W ++ H++ VTWL  W ++I G
Sbjct: 521 MGMLKRRIMPEDIIINCSKDAKVPP-PPPGHKWKEVRHDNKVTWLVSWTENIQG 573

[170][TOP]
>UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C88D
          Length = 609

 Score =  136 bits (343), Expect = 8e-31
 Identities = 69/174 (39%), Positives = 105/174 (60%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEK 177
           VA ++A  L  ++  KE FR+NFF D+R  +   +  ++I  L+KCDF  + A H E  +
Sbjct: 100 VALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVE 158

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           A+K   K+     E+   +EA  + V ++   ++D   E +GNF++EPP LF GRGDHP 
Sbjct: 159 ARKNLSKE-----EKLVNKEANQKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPK 213

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +K+RI+PEDV +N    + IPE P  GH W ++ H+  VTWLA W +++ G
Sbjct: 214 QGMLKKRIRPEDVIINCSKESRIPEAPA-GHKWKEVRHDKTVTWLASWTENVQG 266

[171][TOP]
>UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU
          Length = 767

 Score =  136 bits (343), Expect = 8e-31
 Identities = 69/174 (39%), Positives = 108/174 (62%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +  +      
Sbjct: 258 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGMNDYF----- 311

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
           K ++E + Q + E K+  + + ER+ Q +   ++D  +E +GNFR+EPP LF GRGDHP 
Sbjct: 312 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 371

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA W ++I G
Sbjct: 372 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 424

[172][TOP]
>UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=Q0V9D3_XENTR
          Length = 495

 Score =  136 bits (343), Expect = 8e-31
 Identities = 66/173 (38%), Positives = 107/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA+F+A  L  ++  KE FR+N+F D+R  +   +   VIT L KCDF+ +  + +    
Sbjct: 172 VASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG--- 227

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            K  EKK ++  ++ + +E   + ++++    +D   E +GNF++EPP LF GRGDHP  
Sbjct: 228 -KMEEKKNKSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQ 286

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +K+RI PED+ +N   ++ IPE P PGH W ++ H++ VTWLA W +++ G
Sbjct: 287 GMLKKRILPEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQG 338

[173][TOP]
>UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA
          Length = 969

 Score =  136 bits (343), Expect = 8e-31
 Identities = 68/174 (39%), Positives = 107/174 (61%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA  L+ D+  K+ F  NFF D+R  +   +  + IT LEKC+F  + A+  +   
Sbjct: 481 VAGFYARMLEHDYTSKQAFNDNFFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEI-- 537

Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
              AE+    + E K A +A  E++ +++ + ++DG +E +GNF++EPP LF GRG+HP 
Sbjct: 538 ---AEQNRNRSKEEKAALKAANEQLTKEYGICVIDGHKEKIGNFKIEPPGLFRGRGEHPK 594

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G VKRR+ PEDV +N   ++ IP  P PG  W ++ H++ V+WLA W +++ G
Sbjct: 595 MGLVKRRVMPEDVIINCSQDSKIPS-PPPGRRWKEVRHDNTVSWLASWVENVQG 647

[174][TOP]
>UniRef100_A7SLG4 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SLG4_NEMVE
          Length = 502

 Score =  136 bits (343), Expect = 8e-31
 Identities = 66/165 (40%), Positives = 102/165 (61%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L+ D+  KE F  NFF+D+R  + + +  K I  L+ CDF  +  + E     K  E+K 
Sbjct: 2   LEHDYTSKEIFNKNFFSDWRKEMTEEE-RKHIKDLKNCDFKEMHKYFE----MKNEERKN 56

Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384
            T  E+ E ++   E + ++   ++D  ++ VGNF++EPP LF GRGDHP  GK+K+R+ 
Sbjct: 57  MTKEEKLEIKKKNEEILNEYGFCMMDHHKQRVGNFKIEPPGLFRGRGDHPKQGKLKKRVM 116

Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           PE+VT+N+G +A +P+ P  GH W K+I +  VTWLA W ++I G
Sbjct: 117 PEEVTINIGKDAKVPD-PPAGHKWKKVICDDTVTWLACWIENIQG 160

[175][TOP]
>UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GB81_AJEDR
          Length = 911

 Score =  136 bits (343), Expect = 8e-31
 Identities = 75/181 (41%), Positives = 103/181 (56%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A +  +  AK        I S + CDF  I 
Sbjct: 320 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKPIF 379

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + E      + EKK    AE+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 380 EYYE----AARLEKKNLPAAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 435

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G +A +P  P PGH W ++ H+   TWLA W+++I 
Sbjct: 436 GRGEHPKTGKVKTRVMPEQITINIGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENIN 494

Query: 517 G 519
           G
Sbjct: 495 G 495

[176][TOP]
>UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina
           RepID=B2AY06_PODAN
          Length = 904

 Score =  136 bits (343), Expect = 8e-31
 Identities = 76/181 (41%), Positives = 105/181 (58%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VATF+ + L  T +V    F+ NFF DFR +L +T  AK        I    K DF++I 
Sbjct: 309 VATFFGAMLHSTQNVENPTFQKNFFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIF 368

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + +     KKA   A+  AE+ E  + EA     +     DGR+E VGNFRVEPP LF 
Sbjct: 369 EYYKGLSEAKKARPAAEKKAEKAEKDKFEAP----YMYCKWDGRKEKVGNFRVEPPGLFR 424

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG VK+R+ PE VT+N+G  A +P+ P  GH W  + H++  TWLA W++++ 
Sbjct: 425 GRGEHPKTGTVKKRVMPEQVTINIGKEAKVPD-PPAGHKWKAVQHDNKATWLAMWQENVN 483

Query: 517 G 519
           G
Sbjct: 484 G 484

[177][TOP]
>UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3S6N7_TRIAD
          Length = 560

 Score =  136 bits (342), Expect = 1e-30
 Identities = 72/175 (41%), Positives = 105/175 (60%), Gaps = 3/175 (1%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEK 177
           A FYA  L  D+  K+ F  NF+ DFR  +  A+    KV +   KCDFS+I      E 
Sbjct: 52  AGFYAKMLDHDYTQKKIFNDNFWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EY 103

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
            K KAE++   + E K   + E E + Q +   ++DG  + VGNF++EPP LF GRGDHP
Sbjct: 104 YKMKAEERRNMSKEEKNKLKKENEELMQEYGFCIIDGHRQRVGNFKIEPPGLFRGRGDHP 163

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             GK+KRRI+ +D+ +N+G +A +P  P PG  W ++ +++ VTWLA W ++I G
Sbjct: 164 KQGKIKRRIEAKDIIINIGKDAKLP-APPPGQKWKEVRYDNKVTWLASWTENING 217

[178][TOP]
>UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A45B7
          Length = 1004

 Score =  135 bits (341), Expect = 1e-30
 Identities = 65/173 (37%), Positives = 107/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 495 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 550

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 551 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 609

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P  GH W ++ H++ VTWL  W ++I G
Sbjct: 610 GMLKRRIMPEDIIINCSKDAKVPS-PPTGHKWKEVRHDNKVTWLVSWTENIQG 661

[179][TOP]
>UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30
          Length = 752

 Score =  135 bits (341), Expect = 1e-30
 Identities = 65/173 (37%), Positives = 107/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +    KA
Sbjct: 243 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 298

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A K+  +  E+ + +E   + ++++   ++D   E + NF++EPP LF GRG+HP  
Sbjct: 299 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 357

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI PED+ +N   +A +P  P  GH W ++ H++ VTWL  W ++I G
Sbjct: 358 GMLKRRIMPEDIIINCSKDAKVPS-PPTGHKWKEVRHDNKVTWLVSWTENIQG 409

[180][TOP]
>UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE
          Length = 469

 Score =  135 bits (341), Expect = 1e-30
 Identities = 68/173 (39%), Positives = 106/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF++  L  ++  K+ FR NFF D+R  +   + +K IT L KCDFS +  +    KA
Sbjct: 249 VATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KA 304

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A +KA T  E+ + +E     ++++   ++D  +E + NFR+EPP LF GRGDHP  
Sbjct: 305 QSEA-RKAMTKEEKLKIKEENERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 363

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI+PED+ +N   ++  P  P PG  W ++ H++ VTWL  W ++I G
Sbjct: 364 GMLKRRIRPEDIIINCSKDSKHP-TPPPGTKWKEVRHDNKVTWLVSWTENIQG 415

[181][TOP]
>UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE
          Length = 758

 Score =  135 bits (341), Expect = 1e-30
 Identities = 68/173 (39%), Positives = 106/173 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF++  L  ++  K+ FR NFF D+R  +   + +K IT L KCDFS +  +    KA
Sbjct: 249 VATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KA 304

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           + +A +KA T  E+ + +E     ++++   ++D  +E + NFR+EPP LF GRGDHP  
Sbjct: 305 QSEA-RKAMTKEEKLKIKEENERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 363

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G +KRRI+PED+ +N   ++  P  P PG  W ++ H++ VTWL  W ++I G
Sbjct: 364 GMLKRRIRPEDIIINCSKDSKHP-TPPPGTKWKEVRHDNKVTWLVSWTENIQG 415

[182][TOP]
>UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR
          Length = 1063

 Score =  135 bits (341), Expect = 1e-30
 Identities = 65/172 (37%), Positives = 101/172 (58%)
 Frame = +1

Query: 4    ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
            ATFYA  L  D+  K+ F +NFF DFR  +   K  ++I    KC+F  +    + E  K
Sbjct: 557  ATFYAKMLNHDYCTKDVFNTNFFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEK 615

Query: 184  KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
            +KA  K +   ++ E        V+++   ++DG +E +GNFR+EPP LF GRG+HP  G
Sbjct: 616  RKAATKEEKLLKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 671

Query: 364  KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             +KRRI   DV++N G  + +P+ P+ G  W ++ H++ VTWLA W +++ G
Sbjct: 672  MIKRRIAAADVSINCGKQSKVPQPPM-GGRWKEVRHDNTVTWLASWTENVQG 722

[183][TOP]
>UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus
           RepID=B0WA62_CULQU
          Length = 962

 Score =  135 bits (340), Expect = 2e-30
 Identities = 67/173 (38%), Positives = 104/173 (60%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA  ++ ++  K+ F  NFF D+R  +  ++  K I  L+KC+F  + A+  D   
Sbjct: 458 VAGFYARMIEHEYTSKDVFNDNFFKDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSE 516

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K +   K +  A  KE  EA    V+++ +  +DG +E +GNFR+EPP LF GRG+HP  
Sbjct: 517 KNRNRSKEEKLA-LKEQNEA---LVKEYGICNIDGHKEKIGNFRIEPPGLFRGRGEHPKM 572

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G VKRR+ PEDV +N   ++  P+ P  GH W ++ H++ V+WLA W +++ G
Sbjct: 573 GLVKRRVMPEDVIINCAKDSVYPKAP-EGHRWKEVRHDNTVSWLASWTENVQG 624

[184][TOP]
>UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01
           RepID=C1H484_PARBA
          Length = 900

 Score =  135 bits (340), Expect = 2e-30
 Identities = 76/181 (41%), Positives = 102/181 (56%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A +  +  AK        I S +KCDF  I 
Sbjct: 309 VAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKPIF 368

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
              E      + EKKA   AE+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 369 EFYE----AARLEKKALPAAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 424

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 425 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-TPPAGHKWKEVKHDQEGTWLAMWQENIN 483

Query: 517 G 519
           G
Sbjct: 484 G 484

[185][TOP]
>UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia
           guttata RepID=UPI000194BDF0
          Length = 662

 Score =  135 bits (339), Expect = 2e-30
 Identities = 66/172 (38%), Positives = 105/172 (61%), Gaps = 1/172 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +ATFYA  L  ++  KE F++NFF D+R  +   +  ++I  L+KCDF  I  +  ++  
Sbjct: 153 IATFYAKMLNHEYTTKEIFQNNFFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEKNE 211

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +K   K     E K+  + EA+++++ +   ++DG  E +GNF+ EPP LF GRG+HP 
Sbjct: 212 ARKGLPK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGEHPK 266

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            G +K+RI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W ++I
Sbjct: 267 MGMLKKRIMPEDVIINCSKDSKIPE-PPEGHKWKEVRFDNTVTWLASWTENI 317

[186][TOP]
>UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG
          Length = 806

 Score =  135 bits (339), Expect = 2e-30
 Identities = 74/192 (38%), Positives = 108/192 (56%), Gaps = 19/192 (9%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATF+A  L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  + + +  
Sbjct: 224 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTE 282

Query: 181 KKKAEKKAQTTAE------RKEAREA------------EAERV-RQFTVALVDGREETVG 303
            +KA  K +          R+  R A            E ER+ +QF   ++D  +E + 
Sbjct: 283 ARKAMTKEEKLVSPHPHSCRRRLRAAGFIPSAFQKIKEENERILQQFGFCIMDNHKERIA 342

Query: 304 NFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCV 483
           NFR+EPP LF GRGDHP  G +KRRI+PED+ +N   ++  PE P PG  W ++ H++ V
Sbjct: 343 NFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKV 401

Query: 484 TWLAGWKDSITG 519
           TWL  W ++I G
Sbjct: 402 TWLVSWTENIQG 413

[187][TOP]
>UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI
          Length = 871

 Score =  135 bits (339), Expect = 2e-30
 Identities = 74/181 (40%), Positives = 104/181 (57%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VA F+ S L  T H     F+ NFFADF+ +L  T  AK        I    KCD   I 
Sbjct: 280 VAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIF 339

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + + ++     EKKA   AE+K  +  +  +   +   + DGR++ VGNFRVEPP+LF 
Sbjct: 340 QYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFR 395

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG+VK R+QPE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 396 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 454

Query: 517 G 519
           G
Sbjct: 455 G 455

[188][TOP]
>UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1
           Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294
          Length = 786

 Score =  134 bits (338), Expect = 3e-30
 Identities = 69/175 (39%), Positives = 105/175 (60%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRA-LLADTKFAKVITSLEKCDFSRIEAHLEDEK 177
           VATF+A  L  ++  K+ FR NFF D++  + AD +   +IT+L KCDF+ +  +     
Sbjct: 275 VATFFAKMLDHEYTTKDIFRKNFFKDWKKEMTADER--NLITNLGKCDFNAMSQYF---- 328

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
            K+++E +   T E K+  + E ER+ Q +   ++D   E + NFR+EPP LF GRGDHP
Sbjct: 329 -KEQSEARKNMTKEEKQKIKEENERLLQEYGFCVMDNHRERIANFRIEPPGLFRGRGDHP 387

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             GK+K+RI PED+ +N   ++  P  P  GH W ++ H+  VTWL  W ++I G
Sbjct: 388 KMGKLKKRIMPEDIIINCSKDSKYPVAPA-GHKWKEVRHDGKVTWLVSWTENIQG 441

[189][TOP]
>UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7EXF7_SCLS1
          Length = 911

 Score =  134 bits (338), Expect = 3e-30
 Identities = 74/181 (40%), Positives = 102/181 (56%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           +A F+ + L + H V    F+ NFF DF   +  T  AK        I    K DF  I 
Sbjct: 316 IAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIF 375

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + +     K  E+KA++ AE+K  + A+ E    +   + DGR+E VGNFRVEPP LF 
Sbjct: 376 EYYDG----KSTERKARSAAEKKAEKAAKDEAEAPYKTCIWDGRKEDVGNFRVEPPGLFR 431

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P  GH W  I H++  TWLA W+++I 
Sbjct: 432 GRGEHPKTGKVKLRVTPEQITINIGKEATVPS-PPEGHKWKAIQHDNKATWLAMWQENIN 490

Query: 517 G 519
           G
Sbjct: 491 G 491

[190][TOP]
>UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea
           RepID=A4R0K7_MAGGR
          Length = 906

 Score =  134 bits (337), Expect = 4e-30
 Identities = 79/181 (43%), Positives = 101/181 (55%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156
           VATF+ S L  T +V    F  NFF  F+  L  T  AK        I   EK DF  I 
Sbjct: 310 VATFFGSMLHSTQNVENPTFIKNFFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIF 369

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            H + +   KKA  K +  AE KEAR+   E    +     DGR+E VGNFRVEPP LF 
Sbjct: 370 QHFQAQSEAKKARSKEEKKAE-KEARDKMEE---PYKYCKWDGRKEKVGNFRVEPPALFR 425

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TG +K R+ PE VT+N+G  A +PE P  GH W  + H++  TWLA W++++ 
Sbjct: 426 GRGEHPKTGTIKERVPPEAVTINIGKGAKVPE-PPAGHKWKAVQHDNKATWLAMWQENVN 484

Query: 517 G 519
           G
Sbjct: 485 G 485

[191][TOP]
>UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3173
          Length = 622

 Score =  134 bits (336), Expect = 5e-30
 Identities = 71/177 (40%), Positives = 104/177 (58%), Gaps = 4/177 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA F+A  L  ++  K+ FR NFF D+R  + D +   +I  L+KCDF  I A     KA
Sbjct: 106 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAM---HKA 161

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K +A K   +  E+   +EA  + + ++   L+D   E +GNF++EPP LF GRG+HP  
Sbjct: 162 KVEARKN-MSKEEKLVLKEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQ 220

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVP----GHNWGKIIHNSCVTWLAGWKDSITG 519
           GK+K+RIQPEDV +N   +    E  +P    GH W ++ H++ VTWLA W ++I G
Sbjct: 221 GKLKKRIQPEDVIINCSNSRVDRESRIPVPPAGHRWKEVRHDNTVTWLASWTENIQG 277

[192][TOP]
>UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18
           RepID=C1GKM6_PARBD
          Length = 825

 Score =  134 bits (336), Expect = 5e-30
 Identities = 75/181 (41%), Positives = 101/181 (55%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A +  +  AK        I S +KCDF  I 
Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIF 373

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
              E      + EKKA    E+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 374 EFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 429

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 430 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENIN 488

Query: 517 G 519
           G
Sbjct: 489 G 489

[193][TOP]
>UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0SEQ3_PARBP
          Length = 905

 Score =  134 bits (336), Expect = 5e-30
 Identities = 75/181 (41%), Positives = 101/181 (55%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           VA F+ S L + H V    F+ NFF DF A +  +  AK        I S +KCDF  I 
Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIF 373

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
              E      + EKKA    E+K  +  + E    +   + DGR++ VGNFRVEPP LF 
Sbjct: 374 EFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 429

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G  A +P  P  GH W ++ H+   TWLA W+++I 
Sbjct: 430 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENIN 488

Query: 517 G 519
           G
Sbjct: 489 G 489

[194][TOP]
>UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A49
          Length = 692

 Score =  133 bits (335), Expect = 6e-30
 Identities = 70/180 (38%), Positives = 101/180 (56%), Gaps = 7/180 (3%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEK 177
           VA F+A  L  ++  K+ FR NFF D+R  + D +   +I  L KCDF  I A H    +
Sbjct: 121 VALFFAQMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAMHKAKVE 179

Query: 178 AKKKAEKKAQTTAE------RKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 339
           A+K   K+ +          +   +EA  + V +F   L+D   E +GNF++EPP LF G
Sbjct: 180 ARKNMTKEEKQVCNIHFIMLKNALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRG 239

Query: 340 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           RG+HP  G +K+RIQPED+ +N    A IP  P  GH W ++ H++ VTWL  W ++I G
Sbjct: 240 RGEHPKQGMLKKRIQPEDIIINCSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTENIQG 298

[195][TOP]
>UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana
           B05.10 RepID=A6S3Q9_BOTFB
          Length = 912

 Score =  133 bits (335), Expect = 6e-30
 Identities = 74/181 (40%), Positives = 102/181 (56%), Gaps = 8/181 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156
           +A F+ + L + H V    F+ NFF DF   +  T  AK        I    K DF  I 
Sbjct: 317 IAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIF 376

Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336
            + + +  ++KA   A+  AE+    EAEA     +   + DGR+E VGNFRVEPP LF 
Sbjct: 377 EYYDGKSTERKARSAAEKKAEKALKDEAEAP----YKTCIWDGRKEDVGNFRVEPPGLFR 432

Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           GRG+HP TGKVK R+ PE +T+N+G +A +P  P  GH W  I H++  TWLA W+++I 
Sbjct: 433 GRGEHPKTGKVKLRVTPEQITINIGKDATVPS-PPEGHKWKAIQHDNKATWLAMWQENIN 491

Query: 517 G 519
           G
Sbjct: 492 G 492

[196][TOP]
>UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE
          Length = 966

 Score =  132 bits (333), Expect = 1e-29
 Identities = 66/173 (38%), Positives = 101/173 (58%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +A FYA  L+ ++  K+ F  NFF D+R  +  ++  K I  L+KC+F  +  H  +   
Sbjct: 463 IAGFYARMLEHEYTSKDAFNDNFFKDWRKSMTSSEREK-IKDLKKCNFRSMHKHFAEISE 521

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
             +   K Q  A  KE  EA    ++++    +DG +E +GNFR+EPP LF GRG+HP  
Sbjct: 522 ANRNRTKEQKLA-LKEQNEA---LMKEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHPKM 577

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G VKRR+ PEDV +N G  +  P+ P  GH W ++ H++ V+WLA W +++ G
Sbjct: 578 GMVKRRVMPEDVIINCGKESVWPKAP-EGHRWKEVRHDNSVSWLASWTENVQG 629

[197][TOP]
>UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66
           RepID=B6ABX7_9CRYT
          Length = 660

 Score =  132 bits (333), Expect = 1e-29
 Identities = 71/173 (41%), Positives = 105/173 (60%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +AT++A  L T+   KE+F  N    F + +          + +KCDFS I+ H ++EK 
Sbjct: 90  IATYWAQILDTEWSSKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEEKE 149

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           +KK   K Q   +++   E+E+     +  ALVD  +E VGNFR+EPP LF GRG+HP +
Sbjct: 150 RKKNMNKEQKEQQKRIKNESESP----YIYALVDWIKEKVGNFRIEPPGLFRGRGEHPKS 205

Query: 361 GKVKRRIQPEDVTLNLGPNAPIP--ECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +K+RI  E+VTLN+  +AP+P  +  + GH W  + H+S VTWLA +KDSI
Sbjct: 206 GMLKKRIFSEEVTLNVAEDAPVPKVDSSIIGHAWKDVFHDSNVTWLAYYKDSI 258

[198][TOP]
>UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9SIQ6_9PEZI
          Length = 891

 Score =  132 bits (333), Expect = 1e-29
 Identities = 69/176 (39%), Positives = 109/176 (61%), Gaps = 4/176 (2%)
 Frame = +1

Query: 4   ATFYASKLQT-DHVLKEKFRSNFFADFRALLADTKFA--KVITSLEKCDFSRIEAH-LED 171
           A F+ S   + ++V    F+ NFF DFR ++ +   A  K    ++  DF +I    + D
Sbjct: 298 AWFFGSMFHSKNNVDNPTFQKNFFEDFREVIKEHGSATDKDGKKVDIKDFHKINWQPMAD 357

Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
              ++ A +K +T  E+K+ +E +  R   F   L DGR+E +GNFRVEPP+LF GRGDH
Sbjct: 358 YAEQQSAMRKNRTKEEKKQIKEEKDAREEPFKYCLWDGRKEKMGNFRVEPPSLFRGRGDH 417

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           P TG++K+++ PE +T+N+G +A IP+ P  GH W  ++H++  TWLA W+++I G
Sbjct: 418 PKTGRIKKQVFPEQITINIGKDAKIPK-PPDGHKWKAVVHDNKATWLASWQENING 472

[199][TOP]
>UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni
           RepID=C4Q6C8_SCHMA
          Length = 587

 Score =  132 bits (332), Expect = 1e-29
 Identities = 65/171 (38%), Positives = 101/171 (59%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA  L  D+  KE F  NFF D+   + + +  + I SL KCDF  +  +      
Sbjct: 177 VAGFYARMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----L 231

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K   E+K +T  E+++ +E   +   ++   ++DG ++ +GNFR+EPP LF GRG+HP  
Sbjct: 232 KLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKM 291

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +K+RI PEDV +N   ++ +P  P  GH W ++ H++ VTWLA W ++I
Sbjct: 292 GMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACWTENI 341

[200][TOP]
>UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni
           RepID=C4Q6C7_SCHMA
          Length = 652

 Score =  132 bits (332), Expect = 1e-29
 Identities = 65/171 (38%), Positives = 101/171 (59%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA  L  D+  KE F  NFF D+   + + +  + I SL KCDF  +  +      
Sbjct: 177 VAGFYARMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----L 231

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K   E+K +T  E+++ +E   +   ++   ++DG ++ +GNFR+EPP LF GRG+HP  
Sbjct: 232 KLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKM 291

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +K+RI PEDV +N   ++ +P  P  GH W ++ H++ VTWLA W ++I
Sbjct: 292 GMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACWTENI 341

[201][TOP]
>UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA
          Length = 1019

 Score =  132 bits (331), Expect = 2e-29
 Identities = 71/175 (40%), Positives = 94/175 (53%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174
           +A FYA KL+T H     F  NFF DF+  L     +    I S +K DF  +  +    
Sbjct: 202 IAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSL 261

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
           K  +   KKA   + RK   E       ++ + LVDG E+ VGN  VEPP LFLGRG HP
Sbjct: 262 KDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHP 321

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             GKVKRRI P D+T+N   + P P+ P    +W +++    VTWLA WK++I G
Sbjct: 322 KAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENING 376

[202][TOP]
>UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F98
          Length = 790

 Score =  131 bits (330), Expect = 2e-29
 Identities = 69/188 (36%), Positives = 109/188 (57%), Gaps = 15/188 (7%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 168
           VATF+A  L  ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +    +A  E
Sbjct: 231 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGMNEYFKAQSE 289

Query: 169 DEKAKKKAEKKA-----------QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRV 315
             K   K EK+            +T++   + +E     ++++   ++D  +E +GNFR+
Sbjct: 290 ARKQMSKEEKQVSLHSITCSPALKTSSHLNKIKEDNERILQEYGFCIMDNHKERIGNFRI 349

Query: 316 EPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLA 495
           EPP LF GRGDHP  G +KRRI+PED+ +N   ++  P+ P PG  W ++ H++ VTWLA
Sbjct: 350 EPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLA 408

Query: 496 GWKDSITG 519
            W ++I G
Sbjct: 409 SWTENIQG 416

[203][TOP]
>UniRef100_Q1WWG8 IP16129p (Fragment) n=1 Tax=Drosophila melanogaster
           RepID=Q1WWG8_DROME
          Length = 382

 Score =  131 bits (330), Expect = 2e-29
 Identities = 62/165 (37%), Positives = 98/165 (59%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L  D+  KE F +NFF DFR  +   +  ++I    KC+F  +  + + E  K+KA  K 
Sbjct: 2   LNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKE 60

Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384
           +   ++ E        +++F   ++DG +E +GNFR+EPP LF GRG+HP  G +KRRIQ
Sbjct: 61  EKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQ 116

Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             DV++N G ++ +P  P PG  W ++ H++ VTWLA W +++ G
Sbjct: 117 ASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 160

[204][TOP]
>UniRef100_Q4V7M4 MGC115546 protein n=1 Tax=Xenopus laevis RepID=Q4V7M4_XENLA
          Length = 503

 Score =  131 bits (329), Expect = 3e-29
 Identities = 63/165 (38%), Positives = 101/165 (61%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L  ++  KE FR+NFF D+R  +   +   VIT L+KCDF+ +  + +     K  EKK 
Sbjct: 2   LDHEYTTKEIFRNNFFVDWRKEMT-LEEKMVITDLDKCDFTEMFTYYKG----KMEEKKN 56

Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384
           ++  ++ + +E   + + ++    +D   E +GNF++EPP LF GRGDHP  G +K+RI 
Sbjct: 57  KSKEDKLKIKEENEKLLEEYGYCAMDHHREKIGNFKIEPPALFRGRGDHPKQGMLKKRIL 116

Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           PED+ +N   ++ IPE P PGH W ++ H++ VTWLA W +++ G
Sbjct: 117 PEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQG 160

[205][TOP]
>UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium
           parvum Iowa II RepID=Q5CY81_CRYPV
          Length = 653

 Score =  130 bits (328), Expect = 4e-29
 Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +A++++    T+   KEKF +N    F   +            EKC+F  I+ + EDEK 
Sbjct: 94  IASYWSVMKDTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKE 153

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            KK   K +   ++K   + E+     F  ALVD  +E VGNFR+EPP LF GRG+HP +
Sbjct: 154 AKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNFRIEPPGLFKGRGEHPKS 209

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +KRRI PEDVTLN+  +AP+P+ P  + GH W  I H++ VTWLA ++DSI
Sbjct: 210 GMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRDSI 262

[206][TOP]
>UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis
           RepID=Q5CN58_CRYHO
          Length = 641

 Score =  130 bits (328), Expect = 4e-29
 Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 2/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +A++++    T+   KEKF +N    F   +            EKC+F  I+ + EDEK 
Sbjct: 82  IASYWSVMKDTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKE 141

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            KK   K +   ++K   + E+     F  ALVD  +E VGNFR+EPP LF GRG+HP +
Sbjct: 142 AKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNFRIEPPGLFKGRGEHPKS 197

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +KRRI PEDVTLN+  +AP+P+ P  + GH W  I H++ VTWLA ++DSI
Sbjct: 198 GMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRDSI 250

[207][TOP]
>UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5C1T3_SCHJA
          Length = 330

 Score =  130 bits (327), Expect = 5e-29
 Identities = 64/167 (38%), Positives = 98/167 (58%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA  L  D+  KE F  NFF D+   + + +  + I SL KCDF  +  +      
Sbjct: 169 VAGFYARMLDHDYTTKEVFNHNFFHDWVKTMNEEE-RRTIKSLSKCDFQEMHQYF----L 223

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           K   E+K +T  E+++ +E   +   ++   ++DG ++ +GNFR+EPP LF GRG+HP  
Sbjct: 224 KLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKM 283

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 501
           G +K+RI PEDV +N   ++ +P  P  GH W ++ H++ VTWLA W
Sbjct: 284 GMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACW 329

[208][TOP]
>UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PY85_MALGO
          Length = 877

 Score =  130 bits (326), Expect = 7e-29
 Identities = 71/175 (40%), Positives = 94/175 (53%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174
           VA FYA KL++ H     F  NFF DF   L     K    I   EK DF  +  +    
Sbjct: 161 VAMFYAVKLESQHASNPIFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSL 220

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
           K  +   KK+   + RK    A      ++ + LVDG E+  GN  VEPP LFLGRG HP
Sbjct: 221 KVAEAERKKSMAPSMRKAELAARRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGAHP 280

Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
             G+VK RIQPE +T+N   + P P+ P  GH+WG+++    VTWLA W+++I G
Sbjct: 281 KAGRVKTRIQPEQITINHSADHPPPK-PPKGHSWGEVVERKDVTWLALWRENING 334

[209][TOP]
>UniRef100_UPI000069F011 UPI000069F011 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069F011
          Length = 503

 Score =  128 bits (322), Expect = 2e-28
 Identities = 62/165 (37%), Positives = 101/165 (61%)
 Frame = +1

Query: 25  LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204
           L  ++  KE FR+N+F D+R  +   +   VIT L KCDF+ +  + +     K  EKK 
Sbjct: 2   LDHEYTTKEIFRNNYFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKN 56

Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384
           ++  ++ + +E   + ++++    +D   E +GNF++EPP LF GRGDHP  G +K+RI 
Sbjct: 57  KSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRIL 116

Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           PED+ +N   ++ IPE P PGH W ++ H++ VTWLA W +++ G
Sbjct: 117 PEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQG 160

[210][TOP]
>UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE
          Length = 725

 Score =  128 bits (322), Expect = 2e-28
 Identities = 71/173 (41%), Positives = 101/173 (58%), Gaps = 3/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           + T++A  + + +  KE +R NF +     L  TKF      L+K DF++I  HLE ++ 
Sbjct: 82  LCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIREHLEQQRL 134

Query: 181 ---KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
               K  E+K Q   ER +       R   +  ALVDG  E VGN+ +E P LF GRG+H
Sbjct: 135 LRLNKSDEQKKQEKLERDQ-------RELFYGYALVDGCLERVGNYTLEQPTLFKGRGEH 187

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDS 510
           P  G +K RI PE++T+NL   AP+P+C +PGH+WGKI+H + VTWL  + DS
Sbjct: 188 PKAGLLKARIFPEELTVNLSTQAPVPQCKLPGHSWGKIVHRNDVTWLFSYVDS 240

[211][TOP]
>UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR
          Length = 874

 Score =  127 bits (318), Expect = 6e-28
 Identities = 73/180 (40%), Positives = 102/180 (56%), Gaps = 8/180 (4%)
 Frame = +1

Query: 4   ATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIEA 159
           ATF+   L  T +V    F+ NFF DF+ +L  T  AK        I   EK DFS++ A
Sbjct: 280 ATFFGFMLNSTVNVENPTFQKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWA 339

Query: 160 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 339
           + + +   K A   A+  AE+ E  + +A     +     DGR+E VGN RVE P LF G
Sbjct: 340 YKDAQTKAKNARSSAEKKAEKAERDKRDAP----YLYCKWDGRKEKVGNPRVEIPGLFRG 395

Query: 340 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           RGDHP TG +K+R+ PE +T+N+G  A +PE P  GH W  + H++  TWLA W+++I G
Sbjct: 396 RGDHPKTGCIKKRVLPEQITINIGKEAKVPE-PPAGHKWKAVQHDNKATWLAMWQENING 454

[212][TOP]
>UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI
          Length = 638

 Score =  126 bits (317), Expect = 8e-28
 Identities = 69/172 (40%), Positives = 94/172 (54%)
 Frame = +1

Query: 4   ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183
           ATFYA  L  +      F  NFF DFR L    +  K+I    KC+F  I    + E  K
Sbjct: 120 ATFYAKMLNHECCRNRIFYRNFFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNK 178

Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
           + A  K +  A+RK+        V ++   LVDG  E + NFR+EPP LF GRGDHP  G
Sbjct: 179 RLAATKEEKLAKRKKNEAF----VNKYGFCLVDGHRERISNFRLEPPGLFRGRGDHPKMG 234

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            +KRR+Q  D+ +N G ++ IP  P  G  W ++ H++ VTWLA W D++ G
Sbjct: 235 MIKRRVQACDIIINCGRDSKIP-MPPRGQMWKEVRHDNTVTWLASWVDNVQG 285

[213][TOP]
>UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE
          Length = 596

 Score =  126 bits (317), Expect = 8e-28
 Identities = 70/173 (40%), Positives = 102/173 (58%), Gaps = 3/173 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           + T++A  + + +  KE +R NF +     L  TKF      L+K DF++I+ +LE ++ 
Sbjct: 82  LCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIKEYLEQQRL 134

Query: 181 ---KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351
               K  E+K Q   ER +       R   +  ALVDG  E VGN+ +E P LF GRG+H
Sbjct: 135 LRLNKSDEQKKQEKLERDQ-------RELFYGYALVDGCLERVGNYTLEQPTLFKGRGEH 187

Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDS 510
           P  G +K RI PE++T+NL   AP+P+C +PGH+WGKI+H + VTWL  + DS
Sbjct: 188 PKAGLLKARIFPEELTVNLSTQAPVPQCKLPGHSWGKIVHRNDVTWLFSYVDS 240

[214][TOP]
>UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7
          Length = 839

 Score =  125 bits (315), Expect = 1e-27
 Identities = 71/179 (39%), Positives = 104/179 (58%), Gaps = 8/179 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIE----AH 162
           +AT++ S + +D+  KEKF  NFF  F   L +    K    T L+K D S  +      
Sbjct: 193 LATYWCSAIGSDYCTKEKFILNFFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMP 252

Query: 163 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 342
           ++D   K + EK  +T  E++E ++   E+   +T ALVD   E + + + EPP LF GR
Sbjct: 253 IKDHLLKLREEKLNKTKEEKEEEKKMRMEKELPYTYALVDWIREKISSNKAEPPGLFRGR 312

Query: 343 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G+HP  G +K+RI PEDV +N+  +AP+P     + GHNWG I H++ VTWLA +KDSI
Sbjct: 313 GEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDNMCGHNWGDIYHDNKVTWLAYYKDSI 371

[215][TOP]
>UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A2H9_NITMS
          Length = 551

 Score =  125 bits (315), Expect = 1e-27
 Identities = 77/172 (44%), Positives = 101/172 (58%), Gaps = 4/172 (2%)
 Frame = +1

Query: 13  YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK-- 186
           +A K  T +   + F+ NF ADF   L D+KF K+  S E  DFS     ++ EK  K  
Sbjct: 44  WAKKKDTPYAQDKVFQKNFTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEM 100

Query: 187 --KAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
             K EKKA   A+RKE RE   E   ++ VA++DG+E  VGN+  EPP +F+GRG+HPL 
Sbjct: 101 MTKEEKKA-IAAKRKELRE---ELKSKYGVAVMDGKEVEVGNYMAEPPGIFIGRGEHPLR 156

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           G+ K R+  +DVTLNLG  A +PE       WGKIIH+    WLA W D +T
Sbjct: 157 GRWKPRVTAKDVTLNLGKEAKVPE-----GKWGKIIHDKDSMWLASWMDFLT 203

[216][TOP]
>UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2BD10
          Length = 349

 Score =  125 bits (313), Expect = 2e-27
 Identities = 66/154 (42%), Positives = 95/154 (61%), Gaps = 1/154 (0%)
 Frame = +1

Query: 55  FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 234
           FR  F  D + +  + +  K+IT+L KCDF+ I  +      +K  EKK  T    KE  
Sbjct: 191 FRMFFACDCQEMTKEER--KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----KEVL 240

Query: 235 EAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLG 411
           + EA R+  +F   L+DG  E +GNF++EPP LF GRG+HP  G++K+RIQPEDV +N  
Sbjct: 241 KDEAARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCS 300

Query: 412 PNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            ++ IPE P  GH W ++ H++ VTWLA W ++I
Sbjct: 301 KDSKIPE-PPAGHKWKRVQHDNTVTWLASWLENI 333

[217][TOP]
>UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO
          Length = 701

 Score =  124 bits (310), Expect = 5e-27
 Identities = 70/175 (40%), Positives = 100/175 (57%), Gaps = 4/175 (2%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTK-FAKVITSLEKCDFSRIEAHLEDEK 177
           VATF+A  + T++   E +R NF+  F ++        K   +L+ CDFS I AHL+ E+
Sbjct: 153 VATFWAQSIGTNYEESEIYRRNFWNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHLDMER 212

Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            KKK +K+       K  +E  A++   +  ALVD   E VG+ R+EPP LF GRG HP 
Sbjct: 213 EKKKEQKEYY-----KALKEETAKKEHPYCYALVDWIREKVGSNRMEPPGLFKGRGLHPK 267

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPV---PGHNWGKIIHNSCVTWLAGWKDSI 513
            G +K R  P  V LNL  +AP+P+  +    GH W  I H+S VTWLA ++D++
Sbjct: 268 QGLLKGRTFPHSVVLNLSKDAPVPKVSMFERQGHGWSDIFHDSSVTWLAYYRDTV 322

[218][TOP]
>UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1
           Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH
          Length = 713

 Score =  123 bits (309), Expect = 7e-27
 Identities = 70/188 (37%), Positives = 98/188 (52%), Gaps = 19/188 (10%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +AT+++  L TD   K K+R NF   F       K        +K DF+ I+ HLE++K 
Sbjct: 173 MATYWSQTLGTDWEHKPKYRENFSKQFLDTFGKDKGKY---DFDKFDFTPIKIHLEEQKE 229

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTV-ALVDGREETVGNFRVEPPNLFLGRGDHPL 357
            +K   K     E K   + + ER+  +   A++DG  E VG F +EPP LF GRG+HP 
Sbjct: 230 IRKNRSK-----EEKNQEKQKKERLSDYYAGAILDGFREKVGQFMIEPPTLFKGRGEHPK 284

Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVP------------------GHNWGKIIHNSCV 483
            G +K RIQPE V +N+  +AP+P+C VP                  GH W +I+H   V
Sbjct: 285 MGMMKGRIQPEAVVINISKDAPVPKCSVPDCIHICRQIFNEFPKKQLGHGWSEIVHKQDV 344

Query: 484 TWLAGWKD 507
           TWLA +KD
Sbjct: 345 TWLASYKD 352

[219][TOP]
>UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG
           RepID=B9Q6S5_TOXGO
          Length = 953

 Score =  122 bits (307), Expect = 1e-26
 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE--------- 132
           VA ++   L++D+  K +F  NF+  F         +L +  FA+   + E         
Sbjct: 345 VANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVG 404

Query: 133 --KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 306
              CDFS I+ +L+    K+K  KK  +  E++  ++ + +    +  ALVD   E VGN
Sbjct: 405 FAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGN 460

Query: 307 FRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVT 486
            RVEPP LF GRG+HP  G +KRRI   DV LNL  +AP+P   +PGH W  + H++ VT
Sbjct: 461 TRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVT 520

Query: 487 WLAGWKDSI 513
           WLA ++DSI
Sbjct: 521 WLAFYRDSI 529

[220][TOP]
>UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1
           RepID=B9PWF4_TOXGO
          Length = 953

 Score =  122 bits (307), Expect = 1e-26
 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE--------- 132
           VA ++   L++D+  K +F  NF+  F         +L +  FA+   + E         
Sbjct: 345 VANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVG 404

Query: 133 --KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 306
              CDFS I+ +L+    K+K  KK  +  E++  ++ + +    +  ALVD   E VGN
Sbjct: 405 FAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGN 460

Query: 307 FRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVT 486
            RVEPP LF GRG+HP  G +KRRI   DV LNL  +AP+P   +PGH W  + H++ VT
Sbjct: 461 TRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVT 520

Query: 487 WLAGWKDSI 513
           WLA ++DSI
Sbjct: 521 WLAFYRDSI 529

[221][TOP]
>UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49
           RepID=B6KM03_TOXGO
          Length = 953

 Score =  122 bits (307), Expect = 1e-26
 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE--------- 132
           VA ++   L++D+  K +F  NF+  F         +L +  FA+   + E         
Sbjct: 345 VANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVG 404

Query: 133 --KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 306
              CDFS I+ +L+    K+K  KK  +  E++  ++ + +    +  ALVD   E VGN
Sbjct: 405 FAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGN 460

Query: 307 FRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVT 486
            RVEPP LF GRG+HP  G +KRRI   DV LNL  +AP+P   +PGH W  + H++ VT
Sbjct: 461 TRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVT 520

Query: 487 WLAGWKDSI 513
           WLA ++DSI
Sbjct: 521 WLAFYRDSI 529

[222][TOP]
>UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H
           RepID=B3L6G4_PLAKH
          Length = 924

 Score =  121 bits (303), Expect = 3e-26
 Identities = 68/179 (37%), Positives = 102/179 (56%), Gaps = 8/179 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITS--LEKCDFSRIE----AH 162
           +AT++ S + +D+  KEKF  NFF  F   L      +      L+K D S  +      
Sbjct: 227 LATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDFMP 286

Query: 163 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 342
           ++D   K + EK  +T  E++E ++  +E+    T ALVD   E + + + EPP LF GR
Sbjct: 287 IKDHLVKLREEKLNRTKEEKEEEKKLRSEKELPHTYALVDWIREKISSNKAEPPGLFRGR 346

Query: 343 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G+HP  G +K+RI PEDV +N+  +AP+P     + GH+WG I H++ VTWLA +KDSI
Sbjct: 347 GEHPKQGLLKKRIFPEDVVINISKDAPVPRLYGDMCGHSWGDIYHDNKVTWLAYYKDSI 405

[223][TOP]
>UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1
           Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO
          Length = 886

 Score =  119 bits (299), Expect = 9e-26
 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDFSR 150
           +AT++ S + TD+  K+KF  NFF  F   L      +           I++ +  DF  
Sbjct: 245 LATYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENENKIKNGDISNFKFIDFMT 304

Query: 151 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 330
           I+ HL     K + E+  +T  E++E ++   E+   +T ALVD   E + + + EPP L
Sbjct: 305 IKEHL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREKISSNKAEPPGL 360

Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWK 504
           F GRG+HP  G +K+RI PEDV +N+  +AP P     + GHNWG I H++ VTWLA +K
Sbjct: 361 FRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYK 420

Query: 505 DSI 513
           DSI
Sbjct: 421 DSI 423

[224][TOP]
>UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax
           RepID=A5KB33_PLAVI
          Length = 931

 Score =  119 bits (298), Expect = 1e-25
 Identities = 67/179 (37%), Positives = 102/179 (56%), Gaps = 8/179 (4%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIE----AH 162
           +AT++ S + +D+  KEKF  NFF  F   L      +    + L+K D S  +      
Sbjct: 227 LATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDFMP 286

Query: 163 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 342
           ++D   K + EK  +T  E++E ++  +E+   +T ALVD   E + + + EPP LF GR
Sbjct: 287 IKDHLVKLREEKLNRTKEEKEEEKKLRSEKELPYTYALVDWIREKISSNKAEPPGLFRGR 346

Query: 343 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G+HP  G +K+RI PEDV +N+  +AP+P     + GH WG   H++ VTWLA +KDSI
Sbjct: 347 GEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDDMCGHCWGDTYHDNKVTWLAYYKDSI 405

[225][TOP]
>UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)
           (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD
          Length = 620

 Score =  119 bits (297), Expect = 2e-25
 Identities = 63/171 (36%), Positives = 105/171 (61%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFY  KL  ++  KE F++NFF+D+R  +   +  +VI  L++CDF+ I  H  D   
Sbjct: 49  VATFYGKKLDREYT-KEVFQNNFFSDWRKEMTAEE-GRVIKHLDRCDFTEIHRHSVD--- 103

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
            K A +KA +  E+++ +E E +  ++F  +++DG  E +G+F+ EP ++  GRGDHP  
Sbjct: 104 -KTASQKALSREEKQKLKEEEEKLQQEFGCSILDGHREKIGSFKTEPWSV-RGRGDHPKM 161

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
            ++KRR+ PEDV +N   ++ +PE P  G  W ++  +  V WLA W +++
Sbjct: 162 ERLKRRVLPEDVVINCSRDSTVPE-PPAGPQWKEVGCDCTVMWLAAWTENV 211

[226][TOP]
>UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi
           RepID=Q4XMK5_PLACH
          Length = 429

 Score =  119 bits (297), Expect = 2e-25
 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDFSR 150
           +AT++ S + TD+  K+KF  NFF  F   L      +           I++ +  DF  
Sbjct: 220 LATYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDFMT 279

Query: 151 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 330
           I+ HL     K + E+  +T  E++E ++   E+   +T ALVD   E + + + EPP L
Sbjct: 280 IKEHL----IKLRDERLNKTKEEKEEDKKIRMEKELPYTFALVDWIREKISSNKAEPPGL 335

Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWK 504
           F GRG+HP  G +K+RI PEDV +N+  +AP P     + GHNWG I H++ VTWLA +K
Sbjct: 336 FRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYK 395

Query: 505 DSI 513
           DSI
Sbjct: 396 DSI 398

[227][TOP]
>UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei
           RepID=Q4YYG2_PLABE
          Length = 805

 Score =  118 bits (295), Expect = 3e-25
 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDFSR 150
           +AT++ S + TD+  KEKF  NFF  F   L      +           I++ +  DF  
Sbjct: 190 LATYWCSVIGTDYCTKEKFILNFFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDFMT 249

Query: 151 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 330
           I+ +L     K + E+  +T  E++E ++   E+   +T ALVD   E + + + EPP L
Sbjct: 250 IKENL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREKISSNKAEPPGL 305

Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWK 504
           F GRG+HP  G +K+RI PEDV +N+  +AP P     + GHNWG I H++ VTWLA +K
Sbjct: 306 FRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYK 365

Query: 505 DSI 513
           DSI
Sbjct: 366 DSI 368

[228][TOP]
>UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva
           RepID=Q4N5U3_THEPA
          Length = 1003

 Score =  116 bits (291), Expect = 8e-25
 Identities = 69/174 (39%), Positives = 99/174 (56%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +AT +A  + T++   + +  NF+  F +      F +    L   DFS I+ HLEDEK 
Sbjct: 374 IATMWAQSIGTNYETSDIYCKNFWQVFVSKFEKDHFIRRC-KLTDVDFSLIKTHLEDEKQ 432

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK  K+       K  ++ +A+R  +F  ALVD   E V + ++EPP LF GRG HP  
Sbjct: 433 KKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSSNKLEPPGLFKGRGLHPKQ 487

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +K R+ P+DV LNL  +AP+P+       GH+W  I H++ VTWLA +KDSI
Sbjct: 488 GLLKARMFPKDVILNLSKDAPVPKVSNFQREGHSWKDIYHDNSVTWLAYYKDSI 541

[229][TOP]
>UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata
           RepID=Q4UDP8_THEAN
          Length = 999

 Score =  116 bits (290), Expect = 1e-24
 Identities = 69/174 (39%), Positives = 99/174 (56%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +AT +A  + T++   E +  NF+  F +      F +    L   DFS I+ HLE+EK 
Sbjct: 375 IATMWAQSMGTNYETSEIYCKNFWQVFVSKFEKDHFIRRC-KLSDADFSLIKNHLEEEKQ 433

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KKK  K+       K  ++ +A+R  +F  ALVD   E V + ++EPP LF GRG HP  
Sbjct: 434 KKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSSNKLEPPGLFKGRGLHPKQ 488

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +K R+ P+DV LNL  +AP+P+       GH+W  I H++ VTWLA +KDSI
Sbjct: 489 GLLKSRMFPKDVILNLSKDAPVPKVTNFQREGHSWKDIYHDNSVTWLAYYKDSI 542

[230][TOP]
>UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA
          Length = 790

 Score =  116 bits (290), Expect = 1e-24
 Identities = 69/174 (39%), Positives = 102/174 (58%), Gaps = 3/174 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A  L+T+++ K KFR NF +D+R +L +     +I +LE CDF+ I    + EK 
Sbjct: 254 VATMFAVMLETEYMTKPKFRENFMSDWRKILGEKH---IIQNLEDCDFTPIYEWHQREKE 310

Query: 181 KKKAEKKAQTTAERKEAREAEAE-RVRQFTVALVDGRE-ETVGNFRVEPPNLFLGRGDHP 354
           KKK      +T E+K  +E + E R  ++  A+VDG   E VGNFRV    +        
Sbjct: 311 KKKQ----MSTDEKKAIKEGKDETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWRAS 366

Query: 355 LTGKVKRRIQPE-DVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
              +VK+ +  + D+T+N+G +APIPE P+PG  W +I H++ VTWLA W D I
Sbjct: 367 KDPQVKKNVYSQIDITINIGKDAPIPEPPIPGERWKEIRHDNTVTWLAFWNDPI 420

[231][TOP]
>UniRef100_UPI000180B1AE PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Ciona
           intestinalis RepID=UPI000180B1AE
          Length = 482

 Score =  114 bits (286), Expect = 3e-24
 Identities = 52/132 (39%), Positives = 84/132 (63%)
 Frame = +1

Query: 118 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 297
           IT L KC+F  + ++ +    +K  E+KA++  E++E ++     + +F     DG  E 
Sbjct: 10  ITDLGKCNFRDVCSYFQ----QKSEERKARSKEEKQEEKKKNEALIEEFGFCDWDGHREK 65

Query: 298 VGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNS 477
           +GNFR+EPP LF GRG+HP  GK+K+RI PE++T+N   N+ IP+ P  GH W ++ H++
Sbjct: 66  IGNFRLEPPGLFRGRGNHPKMGKLKKRIIPENITINCSKNSKIPK-PPAGHKWKEVRHDN 124

Query: 478 CVTWLAGWKDSI 513
            VTWL  W +++
Sbjct: 125 AVTWLVSWTENV 136

[232][TOP]
>UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187E0BD
          Length = 265

 Score =  107 bits (268), Expect = 4e-22
 Identities = 59/138 (42%), Positives = 81/138 (58%), Gaps = 2/138 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174
           VA FYA+ ++TDH     F  NFF D+  +L D   +    +T  +KCDF  +  + E E
Sbjct: 123 VAGFYAALIETDHAQDATFNKNFFEDWLKVLQDHPPRNGIKVTDFDKCDFRPMYEYFEAE 182

Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354
           KAKKKA     + AE+KE ++ + E   ++T   +DGR+E VGNFRVEPP LF GRG+HP
Sbjct: 183 KAKKKA----MSAAEKKEIKKQKDEAEAKYTHCFLDGRKEKVGNFRVEPPGLFRGRGEHP 238

Query: 355 LTGKVKRRIQPEDVTLNL 408
             G +K    P  + L L
Sbjct: 239 KKGSLKVIGSPSLIALGL 256

[233][TOP]
>UniRef100_B3TAG0 Putative eukaryotic DNA topoisomerase I, catalytic core n=1
           Tax=uncultured marine crenarchaeote HF4000_APKG8D22
           RepID=B3TAG0_9ARCH
          Length = 563

 Score =  107 bits (268), Expect = 4e-22
 Identities = 56/161 (34%), Positives = 91/161 (56%)
 Frame = +1

Query: 34  DHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTT 213
           D + ++ F S+F   F     + +++ +  SL    +  ++   E+++   K +KKA   
Sbjct: 62  DSIFQKNFVSDFAKTFNGKFKNLQYSDIDFSLA---YQLVDKEKEEKELLTKEDKKA-LA 117

Query: 214 AERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPED 393
            +RKE RE   E   ++   ++DG+E  +GN+  EPP +F+GRG+HP+ G+ K R+  +D
Sbjct: 118 IKRKEIRE---EMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKD 174

Query: 394 VTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           VTLNLG  A IPE       WGKI+H+    W+A W D +T
Sbjct: 175 VTLNLGKEAKIPEA-----KWGKIVHDRNSMWIASWMDILT 210

[234][TOP]
>UniRef100_B3T4E9 Putative eukaryotic DNA topoisomerase I, catalytic core n=1
           Tax=uncultured marine crenarchaeote HF4000_ANIW133O4
           RepID=B3T4E9_9ARCH
          Length = 563

 Score =  106 bits (265), Expect = 8e-22
 Identities = 61/157 (38%), Positives = 88/157 (56%), Gaps = 3/157 (1%)
 Frame = +1

Query: 55  FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERK 225
           F+ NF +DF A   + KF  +  S    DFS     ++ EK +K+    E K     +RK
Sbjct: 65  FQKNFVSDF-AKTFNGKFKNLQYS--DIDFSLAHQLVDKEKEEKELLTKEDKKALAIKRK 121

Query: 226 EAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLN 405
           E RE   E   ++   ++DG+E  +GN+  EPP +F+GRG+HP+ G+ K R+  +DVTLN
Sbjct: 122 EIRE---EMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLN 178

Query: 406 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516
           LG  A IPE       WGKI+H+    W+A W D +T
Sbjct: 179 LGKEAKIPEA-----KWGKIVHDRNSMWIASWMDILT 210

[235][TOP]
>UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI
          Length = 557

 Score =  103 bits (258), Expect = 5e-21
 Identities = 60/175 (34%), Positives = 90/175 (51%), Gaps = 2/175 (1%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  L T  V   +F  NFF DFR+ L+  +     TS + C+F +I  +LE    
Sbjct: 107 VATFYAKVLGTPFVELSEFNENFFKDFRSCLSVEQRLH-FTSFDLCNFQKIHQYLE---- 161

Query: 181 KKKAEKKAQTTAERKEAR-EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357
                       E++EAR + E E   ++    +DG    +  FR++PP L   R  + L
Sbjct: 162 ------------EQQEARSQQELEEDERYGYCYIDGERHRINQFRIKPPGLCCPRKGYSL 209

Query: 358 T-GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           T G ++ R+ PED+ +N    A  P  P PGH W +++H+  V+WL  W D ++G
Sbjct: 210 TMGMIRPRVLPEDIMINCDEYAE-PPAPPPGHRWRQVVHDRSVSWLYSWHDLVSG 263

[236][TOP]
>UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum
           RepID=A0RU10_CENSY
          Length = 519

 Score =  103 bits (258), Expect = 5e-21
 Identities = 63/170 (37%), Positives = 90/170 (52%), Gaps = 3/170 (1%)
 Frame = +1

Query: 13  YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA 192
           +A K  T +   + F+ NF  DF   L      K +      DFS     ++ EK KK  
Sbjct: 44  WAKKKDTPYAQDKVFQKNFARDFAKELGIKLLYKDL------DFSEAYRLVDMEKDKKDM 97

Query: 193 ---EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363
              E+K +  A+RKE RE    +   + +A++DG+E  + ++  EPP +F+GRG HPL G
Sbjct: 98  MTKEEKKEIAAKRKEIREGLKAK---YGIAVMDGKEVEIASYMAEPPGIFIGRGKHPLRG 154

Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           K KRRI P+DV LN+G  A  P    PG  W KI+H     W+A W D++
Sbjct: 155 KWKRRIGPQDVVLNMGTKAKAP----PG-KWKKIVHEKDGIWIAKWTDNL 199

[237][TOP]
>UniRef100_UPI0000E48333 PREDICTED: similar to topoisomerase I alpha isoform 3, partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48333
          Length = 440

 Score =  100 bits (248), Expect = 8e-20
 Identities = 45/98 (45%), Positives = 63/98 (64%)
 Frame = +1

Query: 226 EAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLN 405
           E +    E  +++     DG +E +GNFRVEPP+LF GRG+HP  G++K+RI PEDV +N
Sbjct: 1   ENKRKNEEIQKEYGFCSFDGHKEKIGNFRVEPPSLFRGRGEHPKQGQLKKRIGPEDVIIN 60

Query: 406 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
              ++  P  P  GH W K+IH + VTWLA W ++I G
Sbjct: 61  CSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQG 97

[238][TOP]
>UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO
          Length = 555

 Score = 97.8 bits (242), Expect = 4e-19
 Identities = 57/174 (32%), Positives = 85/174 (48%), Gaps = 1/174 (0%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VATFYA  ++T  V   +F  NFF +FR+ L++ +  + IT  E C+F  I  +LE    
Sbjct: 104 VATFYAKLMKTAFVQMREFNQNFFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLE---- 158

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
                       +R++ +E  AE  + +   LVDG    +  FR+  P L   R     T
Sbjct: 159 -----------CQREDEKERIAEENKLYGYCLVDGESRRITQFRISRPGLCCPRHGFSTT 207

Query: 361 -GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
            G ++ R+ PEDV +N   N   P  P  GH W  ++H+  V W+  W D +TG
Sbjct: 208 MGTIRPRVLPEDVVINCDENEE-PPAPPCGHLWAAVVHDRTVRWVYAWNDIVTG 260

[239][TOP]
>UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN
          Length = 240

 Score = 85.9 bits (211), Expect = 2e-15
 Identities = 54/173 (31%), Positives = 85/173 (49%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           +AT YA  + +   + + F  NFF DF++ L+     + I S E CDF++I  +++ ++ 
Sbjct: 58  LATLYAKFMNSPLAITDTFNENFFKDFQSHLSRA-LRRQILSFELCDFTKIAFYIQGQQG 116

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
               ++K  T   R             +    +DG+   V +F  + P+L+   G  P  
Sbjct: 117 ---VQRKLMTPMMRNH-----------YGYCTIDGKRHRVPHFSFDGPSLYRRSG--PKY 160

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
           G VK RIQPEDV +N   N   P  P  GH W  +IH+  V WL  W D+++G
Sbjct: 161 GMVKPRIQPEDVNINSQENGA-PGAP-DGHTWKSVIHDRRVDWLWSWTDALSG 211

[240][TOP]
>UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major
           RepID=Q7YXA0_LEIMA
          Length = 200

 Score = 81.6 bits (200), Expect = 3e-14
 Identities = 54/124 (43%), Positives = 67/124 (54%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VAT +A   + D+   E F  NFF  +R +L   K    I  LE CDF  I      ++ 
Sbjct: 83  VATMFAVMKEHDYYRMEVFWRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQRE 140

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           KK +  K +  A  KE ++AEAE  R     + DGR E V NFRVEPP LF GRG HPL 
Sbjct: 141 KKLSRTKEEKEAI-KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLM 196

Query: 361 GKVK 372
           GK+K
Sbjct: 197 GKLK 200

[241][TOP]
>UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7
          Length = 879

 Score = 72.4 bits (176), Expect = 2e-11
 Identities = 47/173 (27%), Positives = 76/173 (43%)
 Frame = +1

Query: 1   VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180
           VA FYA  ++ D+  K+ F +NF+ D++ ++   + A +I  ++KC+F +I A+ +    
Sbjct: 420 VAGFYARMIEHDYTTKDVFNNNFYRDWKKVMTHEEKA-IIKDMKKCNFKQIHAYYQ---- 474

Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360
           +K  E+KA +  E                                               
Sbjct: 475 RKSEERKAMSKEE----------------------------------------------- 487

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519
              K+RI PEDV +N   ++  P  P  GH W K+IH + VTWLA W ++I G
Sbjct: 488 ---KQRIGPEDVIINCSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQG 536

[242][TOP]
>UniRef100_Q56XA9 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana
           RepID=Q56XA9_ARATH
          Length = 396

 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 27/51 (52%), Positives = 38/51 (74%)
 Frame = +1

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G++K+RI P ++TLN+G  APIPECP+ G  W ++ H++ VTWLA W D I
Sbjct: 1   GELKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPI 51

[243][TOP]
>UniRef100_B4E061 cDNA FLJ51170, highly similar to DNA topoisomerase I, mitochondrial
           (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4E061_HUMAN
          Length = 477

 Score = 55.5 bits (132), Expect = 2e-06
 Identities = 25/51 (49%), Positives = 34/51 (66%)
 Frame = +1

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +KRRI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +SI
Sbjct: 2   GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESI 51

[244][TOP]
>UniRef100_UPI0001AE6F94 UPI0001AE6F94 related cluster n=1 Tax=Homo sapiens
           RepID=UPI0001AE6F94
          Length = 477

 Score = 55.1 bits (131), Expect = 3e-06
 Identities = 24/51 (47%), Positives = 34/51 (66%)
 Frame = +1

Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513
           G +KRRI PEDV +N   ++ IPE P  GH W ++  ++ VTWLA W +S+
Sbjct: 2   GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESV 51

[245][TOP]
>UniRef100_B9Q1D7 Chloride channel, putative n=1 Tax=Toxoplasma gondii GT1
           RepID=B9Q1D7_TOXGO
          Length = 1756

 Score = 54.3 bits (129), Expect = 5e-06
 Identities = 43/125 (34%), Positives = 53/125 (42%)
 Frame = -3

Query: 403 SASRPRAECGA*PYPSTDGPRDQGIGWAAPHGSCPPSLRDRPPERP*TDEHARPQPHGPP 224
           S+S P +       PS   P       ++P  S PP     PP  P       P P   P
Sbjct: 184 SSSSPSSSPSTSTSPSPSSPPSSSPPSSSPSSSSPPPSSSPPPSSP-------PSPSSAP 236

Query: 223 CARPSSAPSSPPSSSPFHPLSAPRSD*SHTFPGW*SPWQTWCPPGGL*SPRRSWIGTSPS 44
            +  S +PSSPPSSSP  P SAP S    T P   SP  +  P     SP  S   ++PS
Sbjct: 237 SSSTSPSPSSPPSSSPPSPSSAPSSS---TSPSPSSPPPSSPPSSSSTSPSPS---SAPS 290

Query: 43  THGPS 29
           +  PS
Sbjct: 291 SSPPS 295

[246][TOP]
>UniRef100_B6KLS9 Voltage gated chloride channel domain-containing protein n=1
           Tax=Toxoplasma gondii ME49 RepID=B6KLS9_TOXGO
          Length = 1779

 Score = 53.5 bits (127), Expect = 8e-06
 Identities = 44/129 (34%), Positives = 54/129 (41%), Gaps = 3/129 (2%)
 Frame = -3

Query: 409 PGSASRPRAECGA*PYPSTDGPRDQGIGWAAPHGSCPPSLRDRPPERP*TDEHARPQPHG 230
           P S+S P +     P PS+  P       ++P  S PP     PP  P       P P  
Sbjct: 259 PPSSSSPSSSS---PPPSSSPPSSSPPSSSSPSSSSPPPSSSPPPPSP-PSSSTSPSPSS 314

Query: 229 PPCA---RPSSAPSSPPSSSPFHPLSAPRSD*SHTFPGW*SPWQTWCPPGGL*SPRRSWI 59
           PP +    PS  PSSPPSSSP  P S+P S  S + P   SP  +  P      P  S  
Sbjct: 315 PPSSSPPSPSPPPSSPPSSSP--PSSSPPSPPSPSSPPPSSPPSSSSPSSSSPPPSSSPP 372

Query: 58  GTSPSTHGP 32
             SP +  P
Sbjct: 373 PPSPPSSSP 381