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[1][TOP] >UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum RepID=TOP1_DICDI Length = 893 Score = 178 bits (452), Expect = 2e-43 Identities = 83/174 (47%), Positives = 119/174 (68%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA+ L+TDHV K+ F+ NFF +F+ LL + +++ ++KCDFS I HL+ +K Sbjct: 349 VATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKE 407 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 ++KA K E K+A AE +++++ A +DG +E VGN+ +EPP LFLGRG HP Sbjct: 408 QRKARSK-----EEKDAETAEKKKIQEKHGFATIDGFKEKVGNYMIEPPGLFLGRGQHPK 462 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 TG +K+RI P DVTLN+G IP P+PG W +I+HN+ VTWLA W++S+ G Sbjct: 463 TGMLKQRIMPSDVTLNIGEGEVIPPSPIPGEKWKEIVHNNTVTWLAFWRESVNG 516 [2][TOP] >UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO Length = 910 Score = 171 bits (433), Expect = 3e-41 Identities = 84/171 (49%), Positives = 115/171 (67%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A L TD++ K +F+ NFF D++ +L VI +LE CDFS I + EK Sbjct: 403 VATMFAVMLDTDYMNKPRFKENFFGDWKKILGKNH---VIQNLENCDFSPIYEWHQSEKE 459 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK TT E+K +E + ++ ++ A VDG++E VGNFRVEPP LF GRG+HP Sbjct: 460 KKKQ----MTTEEKKALKEEKLKQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKM 515 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI+P D+T+N+G +APIPECPVPG W ++ H++ VTWLA W D I Sbjct: 516 GKLKKRIRPCDITINIGKDAPIPECPVPGERWKEVRHDNTVTWLAFWNDPI 566 [3][TOP] >UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI Length = 857 Score = 169 bits (429), Expect = 8e-41 Identities = 83/171 (48%), Positives = 114/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A L TD++ KEKF+ NF AD+R +L VI L+ CDF+ I ++EK Sbjct: 353 VATMFAVMLDTDYMQKEKFKENFMADWRKILGKNH---VIQRLDDCDFTPIYEWHQEEKE 409 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK +T E+K +E + + ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 410 KKKQ----MSTEEKKTLKEEKLKLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 465 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+KRRI P D+T+N+G N+ IPECP+PG +W ++ H++ VTWLA W D I Sbjct: 466 GKLKRRIHPSDITINIGKNSQIPECPIPGESWKEVKHDNTVTWLAFWNDPI 516 [4][TOP] >UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum bicolor RepID=C5YGY1_SORBI Length = 921 Score = 167 bits (422), Expect = 5e-40 Identities = 84/173 (48%), Positives = 113/173 (65%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A TD+ K F NFF D+R +L +I E CDF+ I E HL Sbjct: 416 VATMFAVMKDTDYAGKPTFIDNFFTDWRKILGKNH---IIKKFELCDFTPIYEWHL---- 468 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 ++K +KK TT E+K RE + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 469 -REKEKKKQMTTEEKKALREEKLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPK 527 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GK+KRRIQP D+T+N+G AP+PECP+PG +W +I H++ VTWLA W D I+ Sbjct: 528 MGKLKRRIQPSDITINIGKGAPVPECPIPGESWKEIKHDNTVTWLAFWNDPIS 580 [5][TOP] >UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis RepID=B9SSQ1_RICCO Length = 891 Score = 166 bits (420), Expect = 9e-40 Identities = 84/171 (49%), Positives = 112/171 (65%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A TD++ K KF NF+ D+R LL VI LE CDF+ I E EK Sbjct: 385 VATMFAVMKDTDYMQKPKFLENFWNDWRKLLGRNH---VIQKLEDCDFTPIYEWHEREKE 441 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK +T E+K +E + + ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 442 KKKQ----MSTEEKKAQKEEKLRQEEKYMWAIVDGVKEKVGNFRVEPPALFRGRGEHPKM 497 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RIQP D+T+N+G +APIPECP+PG +W ++ H++ VTWLA W D I Sbjct: 498 GKLKKRIQPSDITINIGKDAPIPECPIPGESWKEVKHDNTVTWLAFWNDPI 548 [6][TOP] >UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT Length = 926 Score = 166 bits (420), Expect = 9e-40 Identities = 79/171 (46%), Positives = 113/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A+ L TD++ K +F+ NFF+D++ +L I +LE CDF I + EK Sbjct: 420 VATMFAAMLDTDYMNKPRFKENFFSDWKKILGKNH---TIQNLEDCDFGPIYEWHQQEKE 476 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK TT E+K +E + ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 477 KKKQ----MTTEEKKALKEERLQLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKV 532 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI+P D+T+N+G +APIPECP+PG W ++ +++ VTWLA W D + Sbjct: 533 GKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPV 583 [7][TOP] >UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC Length = 852 Score = 165 bits (418), Expect = 2e-39 Identities = 81/171 (47%), Positives = 111/171 (64%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT YA L TD++ K +F+ NF D+R +L VI +L+ CDF+ I EK Sbjct: 372 VATMYAVMLDTDYMSKLQFKENFMNDWRKILGKNH---VIQNLDDCDFTPIYERPSSEKE 428 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK +T ++ RE + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 429 KKKQ----MSTKRKRPLREEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 484 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+KRRI+P D+T+N+G APIPECP+PG W ++ H++ VTWLA W D I Sbjct: 485 GKLKRRIRPNDITINIGKGAPIPECPIPGERWKEVRHDNTVTWLAFWNDPI 535 [8][TOP] >UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q84ZL5_ORYSJ Length = 916 Score = 165 bits (418), Expect = 2e-39 Identities = 82/173 (47%), Positives = 114/173 (65%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A TD+ K+ F NFF D+R +L VI E CDF+ I E HL Sbjct: 411 VATMFAVMKDTDYASKQTFIDNFFTDWRKILGKNH---VIKKFELCDFTPIYEWHL---- 463 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 ++K +KK T+ E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 464 -REKEKKKQMTSEEKKALKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPK 522 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GK+KRRI+P D+T+N+G APIPECP+PG +W ++ H++ VTWLA W D I+ Sbjct: 523 MGKLKRRIKPSDITINIGKGAPIPECPIPGESWKEVKHDNTVTWLAFWNDPIS 575 [9][TOP] >UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT Length = 926 Score = 165 bits (418), Expect = 2e-39 Identities = 78/171 (45%), Positives = 113/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A L TD++ K +F+ NFF+D++ +L + +LE CDF I + EK Sbjct: 420 VATMFAVMLDTDYMTKPRFKENFFSDWKKMLGKNH---TVQNLEDCDFGPIYEWHQQEKE 476 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K+K TT E+K +E ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 477 KRKQ----MTTEEKKALKEERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 532 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI+P D+T+N+G +APIPECP+PG W ++ +++ VTWLA W D I Sbjct: 533 GKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWNDPI 583 [10][TOP] >UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=A2YRB7_ORYSI Length = 916 Score = 165 bits (418), Expect = 2e-39 Identities = 82/173 (47%), Positives = 114/173 (65%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A TD+ K+ F NFF D+R +L VI E CDF+ I E HL Sbjct: 411 VATMFAVMKDTDYASKQTFIDNFFTDWRKILGKNH---VIKKFELCDFTPIYEWHL---- 463 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 ++K +KK T+ E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 464 -REKEKKKQMTSEEKKALKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPK 522 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GK+KRRI+P D+T+N+G APIPECP+PG +W ++ H++ VTWLA W D I+ Sbjct: 523 MGKLKRRIKPSDITINIGKGAPIPECPIPGESWKEVKHDNTVTWLAFWNDPIS 575 [11][TOP] >UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT Length = 927 Score = 165 bits (417), Expect = 2e-39 Identities = 80/171 (46%), Positives = 114/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A L TD++ K +F+ NFF+D++ +L I +LE CDF I + EK Sbjct: 421 VATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNH---TIQNLEDCDFGPIYEWHQQEKE 477 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK TT E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 478 KKKQ----MTTEEKKALKEDKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKM 533 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI+P D+T+N+G +APIPECP+PG W ++ +++ VTWLA W D I Sbjct: 534 GKLKKRIRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWIDPI 584 [12][TOP] >UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI Length = 760 Score = 164 bits (415), Expect = 3e-39 Identities = 84/179 (46%), Positives = 118/179 (65%), Gaps = 8/179 (4%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEA 159 VA F+ + L+TDH F+ NFF DF+A+L ++ AK I + KCDFS + A Sbjct: 174 VAGFFGAMLETDHAKNPTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDMYA 233 Query: 160 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFL 336 H E K + EKKA + AE+K A +AE +++ + F V L++GR+E VGNFR+EPP LF Sbjct: 234 HFE----KMREEKKAMSAAEKK-AIKAERDKIEEPFKVCLLNGRKEQVGNFRIEPPGLFR 288 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GRG HP TGK+KRR+ PE +T+N+G P+PE P GH WG++ H++ V WLA W ++I Sbjct: 289 GRGAHPKTGKLKRRVMPEQITINIGKGVPVPE-PPAGHKWGEVRHDNSVAWLAMWHENI 346 [13][TOP] >UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B7ZWU7_MAIZE Length = 574 Score = 164 bits (414), Expect = 4e-39 Identities = 82/172 (47%), Positives = 111/172 (64%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A TD+ K F NFF D+R +L +I + E CDF+ I E HL Sbjct: 69 VATMFAVMKDTDYAAKPTFIDNFFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL---- 121 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 ++K KK TT E+K RE + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 122 -REKERKKQMTTEEKKTLREDKLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPK 180 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+KRRI P D+T+N+G AP+PECP+PG +W ++ H++ VTWLA W D I Sbjct: 181 MGKLKRRILPSDITINIGKGAPVPECPIPGESWKEVKHDNTVTWLAFWNDPI 232 [14][TOP] >UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE Length = 904 Score = 163 bits (413), Expect = 6e-39 Identities = 82/172 (47%), Positives = 110/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A TD+ K F NFF D+R +L +I + E CDF+ I E HL Sbjct: 399 VATMFAVMKDTDYAAKPTFIDNFFTDWRKVLGKNH---IIKNFELCDFTPIYEWHL---- 451 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 ++K KK TT E+K RE ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 452 -REKERKKQMTTEEKKTLREDNLKQEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPK 510 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+KRRI P D+T+N+G AP+PECP+PG +W ++ H++ VTWLA W D I Sbjct: 511 MGKLKRRILPSDITINIGKGAPVPECPIPGESWKEVKHDNTVTWLAFWNDPI 562 [15][TOP] >UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC Length = 894 Score = 163 bits (413), Expect = 6e-39 Identities = 81/171 (47%), Positives = 113/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A L TD++ K KF+ NF D+R +L VI +LE CDF+ I + EK Sbjct: 389 VATMFAVMLDTDYMTKSKFKENFMDDWRKILGKNH---VIQNLEDCDFTPIYEWHQREKE 445 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK T E+K +E ++ ++ A+V+G +E VGNFRVEPP+LF GRG+HP Sbjct: 446 KKKK----MTAEEKKVLKEERLKQEEKYMWAIVNGVKEKVGNFRVEPPSLFRGRGEHPKM 501 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+ I+P D+T+N+G +APIPECP+PG +W +I H++ VTWLA W D I Sbjct: 502 GKLKKCIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAFWNDPI 552 [16][TOP] >UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR Length = 877 Score = 163 bits (412), Expect = 7e-39 Identities = 81/171 (47%), Positives = 112/171 (65%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A TD+V K +FR NF+ D+R LL VI L+ CDF+ I + EK Sbjct: 372 VATMFAVMKDTDYVQKPQFRQNFWNDWRKLLGKNH---VIQKLDDCDFNPIYEWHQQEKE 428 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK +T E+K +E + ++ ++ A+V+G +E VGNFRVEPP LF GRG+HP Sbjct: 429 KKKQ----MSTEEKKVLKEEKLKQEEKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKM 484 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K RI+P D+T+N+G +APIPECP+PG W ++ H++ VTWLA W D I Sbjct: 485 GKLKSRIRPSDITINIGKDAPIPECPIPGERWKEVKHDNTVTWLAFWNDPI 535 [17][TOP] >UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJG7_9ALVE Length = 551 Score = 163 bits (412), Expect = 7e-39 Identities = 85/171 (49%), Positives = 113/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ Sbjct: 133 VATFFAQTLGTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD---- 187 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K+ KKA+T E++ +EA+ +T +VD E VGNFRVEPPNLF GRGDHP Sbjct: 188 KRSEAKKARTKEEKEAEKEAKRLNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKM 247 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+ I PEDVT+N +AP P CPVPGH + ++H+ VTWLA + D+I Sbjct: 248 GKLKQYILPEDVTVNCAADAPAPRCPVPGHAYKDVVHDPAVTWLAWFTDTI 298 [18][TOP] >UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5L755_9ALVE Length = 647 Score = 163 bits (412), Expect = 7e-39 Identities = 85/171 (49%), Positives = 113/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ Sbjct: 133 VATFFAQTLGTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLD---- 187 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K+ KKA+T E++ +EA+ +T +VD E VGNFRVEPPNLF GRGDHP Sbjct: 188 KRSEAKKARTKEEKEAEKEAKRLNDHPYTHVIVDELRERVGNFRVEPPNLFRGRGDHPKM 247 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+ I PEDVT+N +AP P CPVPGH + ++H+ VTWLA + D+I Sbjct: 248 GKLKQYILPEDVTVNCAADAPAPRCPVPGHAYKDVVHDPAVTWLAWFTDTI 298 [19][TOP] >UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe RepID=TOP1_SCHPO Length = 814 Score = 162 bits (411), Expect = 1e-38 Identities = 74/171 (43%), Positives = 109/171 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA+ L+TDH F+ NFF DF + + F I KCDF+++ H E Sbjct: 234 VAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFE---- 289 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +K+ EKK+ ++K ++ + E ++ ++DGR+E VGNFR+EPP LF GRG HP T Sbjct: 290 QKREEKKSMPKEQKKAIKQKKDEEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHPKT 349 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRR+ PE +T+N+G P+PE P+PGH W ++ H++ VTWLA W ++I Sbjct: 350 GSLKRRVYPEQITINIGEGVPVPE-PLPGHQWAEVKHDNTVTWLATWHENI 399 [20][TOP] >UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST Length = 780 Score = 161 bits (408), Expect = 2e-38 Identities = 85/173 (49%), Positives = 114/173 (65%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA FY + L+TDH F+ NFF DF ++ +T + V I EK DFS+I AH E Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE--- 252 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 K E+K T ++K+A + E ER+ + + L +G +E VGNFRVEPP LF GRG HP Sbjct: 253 --KLREEKKLLTKDQKKAMKEEKERIEEPYKTCLFNGHKELVGNFRVEPPGLFRGRGAHP 310 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 TGK+KRR+ PE VTLN+G A IPE P PGH+WG+I +++ VTWLA W+++I Sbjct: 311 RTGKLKRRVYPEMVTLNIGAGAKIPEAP-PGHSWGEIKNDNTVTWLAMWRENI 362 [21][TOP] >UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XZS7_CLAL4 Length = 764 Score = 161 bits (407), Expect = 3e-38 Identities = 81/173 (46%), Positives = 108/173 (62%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+A L+TDH F+ NFF DF +L + V IT +KCDFS++ AH Sbjct: 182 VAGFFAEMLETDHAKNPVFQKNFFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF---- 237 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K + EKK + AE+ ++ + L++GR E VGNF+VEPP+LF GRG HP Sbjct: 238 VKVREEKKNMSKAEKLRLKQEREALEEPYRTCLLNGRRENVGNFKVEPPSLFRGRGAHPK 297 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+K+R+ PED+TLNLG APIP P GH WG+I H+ V WLA WK++I+ Sbjct: 298 TGKLKKRVYPEDITLNLGIEAPIPPAP-EGHKWGEIRHDKSVVWLAMWKENIS 349 [22][TOP] >UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE Length = 2575 Score = 160 bits (406), Expect = 4e-38 Identities = 78/171 (45%), Positives = 113/171 (66%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A FYA L D+V K+ F NF D+RA + + K +T ++KCDFS I +H + Sbjct: 1908 IAGFYAMMLTRDYVHKDIFNENFMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQRAE 1966 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +KA K E+++ +EAEA+ ++ AL+DGR+ T+GNFR+EPP LF GRG+HP Sbjct: 1967 ARKAASKE----EKEKRKEAEAKLKEEYGFALMDGRKVTIGNFRIEPPGLFQGRGEHPKM 2022 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K R+ PEDV +N+GP +PE P GH W ++ H++ VTWLAGWK++I Sbjct: 2023 GKLKLRVMPEDVIINVGPKDKVPE-PPAGHKWKEVKHDNTVTWLAGWKENI 2072 [23][TOP] >UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59XR0_CANAL Length = 780 Score = 160 bits (406), Expect = 4e-38 Identities = 84/173 (48%), Positives = 111/173 (64%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 198 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE--- 254 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K + EKKA + E+K +E + + + ++GR+E VGNFR+EPP LF GRG HP Sbjct: 255 -KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 313 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+KRR+ PE VTLNLG +A IPE P GH WG+I H++ VTWLA WK++I+ Sbjct: 314 TGKLKRRVVPEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 365 [24][TOP] >UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59WV6_CANAL Length = 780 Score = 160 bits (406), Expect = 4e-38 Identities = 84/173 (48%), Positives = 111/173 (64%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 198 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE--- 254 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K + EKKA + E+K +E + + + ++GR+E VGNFR+EPP LF GRG HP Sbjct: 255 -KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 313 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+KRR+ PE VTLNLG +A IPE P GH WG+I H++ VTWLA WK++I+ Sbjct: 314 TGKLKRRVVPEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 365 [25][TOP] >UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q8RX06_ARATH Length = 514 Score = 160 bits (404), Expect = 6e-38 Identities = 81/172 (47%), Positives = 113/172 (65%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A +TD+ K +FR NF+ D+R LL VI L+ CDF+ I E HLE+ Sbjct: 6 VATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-- 60 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K +KK +T E+K +E + ++ ++ A+VDG +E +GNFRVEPP LF GRG+HP Sbjct: 61 ---KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPK 117 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D I Sbjct: 118 MGKLKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPI 169 [26][TOP] >UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa RepID=B9I1A0_POPTR Length = 860 Score = 160 bits (404), Expect = 6e-38 Identities = 80/171 (46%), Positives = 110/171 (64%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A T++V K +F NF+ D+R LL VI LE CDF+ I + EK Sbjct: 355 VATMFAVMKDTEYVQKPQFLQNFWNDWRTLLGKNH---VIQKLEACDFNPIYEWHQKEKE 411 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK +T E+K RE + ++ + A+V+G +E VGNFRVEPP LF GRG+HP Sbjct: 412 KKKQ----MSTEEKKAVREEKLKQEEMYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKM 467 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K RI+P D+T+N+G +APIP+CP+PG W ++ H++ VTWLA W D I Sbjct: 468 GKLKSRIRPSDITINIGKDAPIPKCPIPGERWKEVKHDNTVTWLAFWNDPI 518 [27][TOP] >UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36 RepID=B9WIH6_CANDC Length = 777 Score = 160 bits (404), Expect = 6e-38 Identities = 84/173 (48%), Positives = 110/173 (63%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 195 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE--- 251 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K + EKKA + E+K +E + + F ++GR+E VGNFR+EPP LF GRG HP Sbjct: 252 -KLREEKKAMSKEEKKRIKEEKEKEEEPFKTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 310 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+KRR+ PE VTLNL +A IPE P GH WG+I H++ VTWLA WK++I+ Sbjct: 311 TGKLKRRVAPEQVTLNLSKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 362 [28][TOP] >UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH Length = 916 Score = 160 bits (404), Expect = 6e-38 Identities = 81/172 (47%), Positives = 113/172 (65%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A +TD+ K +FR NF+ D+R LL VI L+ CDF+ I E HLE+ Sbjct: 408 VATMFAVMRETDYYTKPQFRENFWNDWRRLLGKKH---VIQKLDDCDFTPIYEWHLEE-- 462 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K +KK +T E+K +E + ++ ++ A+VDG +E +GNFRVEPP LF GRG+HP Sbjct: 463 ---KEKKKQMSTEEKKALKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPK 519 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D I Sbjct: 520 MGKLKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPI 571 [29][TOP] >UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum RepID=Q94705_PHYPO Length = 1015 Score = 159 bits (402), Expect = 1e-37 Identities = 80/172 (46%), Positives = 113/172 (65%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L+TD+ KE F +NF++DFR L + KVI K DF+ I +L ++K Sbjct: 449 VATFYAKYLETDYPKKENFNTNFWSDFRTYLTPEQ-KKVIKDFSKADFTHIHKYLVEQK- 506 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 E KA TAE K+A +AE E++ Q + A+++G + + N+ +E P LFLGRG HP Sbjct: 507 ----ELKANRTAEEKKAEKAEKEKLLQKYGFAMINGHRQRISNWAIERPGLFLGRGAHPK 562 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 TG VK+RI+ ED+T+N+G P+PE P PGH W K++H+ V WLA WK++I Sbjct: 563 TGLVKKRIEAEDITINIGKGVPVPE-PPPGHKWCKVVHDDKVAWLAMWKENI 613 [30][TOP] >UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T3W2_PHYPA Length = 632 Score = 159 bits (401), Expect = 1e-37 Identities = 79/171 (46%), Positives = 109/171 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +AT +A L+TD+ KE+F NF+ D++ L VI E CDF+ I D A Sbjct: 128 IATMFAVMLETDYAKKERFIKNFWDDWKPYLGKNH---VIKKFELCDFTPIF----DWHA 180 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 ++K KK+ +T E+K +E + ++ A+VDG +E VGNFRVEPP LF GRGDHP Sbjct: 181 REKERKKSMSTEEKKRLKEEKLAVEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKM 240 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K RI P D+ +N+G +A +PECP+PG W +I H++ VTWLA WKD I Sbjct: 241 GKLKTRILPHDIVINIGKDAAVPECPIPGQRWKEIRHDNTVTWLAYWKDPI 291 [31][TOP] >UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG Length = 763 Score = 159 bits (401), Expect = 1e-37 Identities = 78/173 (45%), Positives = 115/173 (66%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+ + L T+H F++NFF+DF+ ++ + A V I S +KCDFS+I H E +K Sbjct: 180 VACFFGAMLNTEHAQNPAFQNNFFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQK 239 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 + KK+ T A+++E + + + ++ L++GR E VGNFR+EPP LF GRG HP Sbjct: 240 SLKKS----LTAAQKREIKSEKDKFEEKYKYCLLNGRRERVGNFRIEPPGLFRGRGSHPK 295 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TG+VK+RI PEDV+LNL +APIP P GH W +I H++ V WLA W++++T Sbjct: 296 TGRVKKRIYPEDVSLNLSEDAPIPP-PPEGHQWKEIKHDNTVAWLATWRENVT 347 [32][TOP] >UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera RepID=UPI000198447D Length = 883 Score = 158 bits (400), Expect = 2e-37 Identities = 80/171 (46%), Positives = 106/171 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A TD+ K +F NF D+R L VI E CDF+ I E EK Sbjct: 378 VATMFAVMKDTDYATKPRFIENFMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKE 434 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK TT E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 435 KKKQ----MTTEEKKALKEEKLKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKM 490 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI P D+T+N+G AP+PECP+PG W ++ H++ VTWLA W D I Sbjct: 491 GKLKKRICPSDITINIGKEAPVPECPIPGERWKEVRHDNTVTWLAFWNDPI 541 [33][TOP] >UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7PX10_VITVI Length = 789 Score = 158 bits (400), Expect = 2e-37 Identities = 80/171 (46%), Positives = 106/171 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A TD+ K +F NF D+R L VI E CDF+ I E EK Sbjct: 284 VATMFAVMKDTDYATKPRFIENFMNDWRVRLGKNH---VIKKFELCDFTPIYEWHEKEKE 340 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK TT E+K +E + ++ ++ A+VDG +E VGNFRVEPP LF GRG+HP Sbjct: 341 KKKQ----MTTEEKKALKEEKLKQEDKYMWAVVDGVKEKVGNFRVEPPGLFRGRGEHPKM 396 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI P D+T+N+G AP+PECP+PG W ++ H++ VTWLA W D I Sbjct: 397 GKLKKRICPSDITINIGKEAPVPECPIPGERWKEVRHDNTVTWLAFWNDPI 447 [34][TOP] >UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri RepID=Q00XV7_OSTTA Length = 783 Score = 158 bits (399), Expect = 2e-37 Identities = 78/171 (45%), Positives = 105/171 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A F+A TD+ K F NF F+ LA+ A IT KCDF+++ H A Sbjct: 274 IAGFFAVMKDTDYAQKAVFVKNFMDGFKEALANGPHA-FITDFRKCDFTKMYNHF----A 328 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K + EKK T+ E+K + + + +T A +DGR E VGNFR+EPP LF GRG+HP Sbjct: 329 KIREEKKQMTSEEKKRIKAEKDKAEEMYTWATIDGRREKVGNFRIEPPGLFRGRGEHPKM 388 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+KRR+ PED+T+N+G +A +P P PGH+W +IHN TWLAGW D I Sbjct: 389 GKIKRRVMPEDITINIGKDARVPP-PPPGHSWKAVIHNDTATWLAGWNDVI 438 [35][TOP] >UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus RepID=A5E508_LODEL Length = 849 Score = 158 bits (399), Expect = 2e-37 Identities = 81/173 (46%), Positives = 112/173 (64%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+ + ++TDH F+ NFF DF+ +L ++ V I EK DFS+I A+ E Sbjct: 267 VAGFFGAMVETDHAKNPVFQKNFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE--- 323 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 KK+ EKKA + E+K +E + F L++GR+E VGNFR+EPP LF GRG HP Sbjct: 324 -KKREEKKAMSREEKKRLKEEKDRIEEPFKTCLLNGRKELVGNFRIEPPGLFRGRGAHPK 382 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+KRR++PE VTLNL IPE P GH+W ++ H++ VTWLA WK++I+ Sbjct: 383 TGKLKRRVRPEQVTLNLSKGVKIPE-PPAGHHWAEVRHDNEVTWLAMWKENIS 434 [36][TOP] >UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL Length = 778 Score = 157 bits (398), Expect = 3e-37 Identities = 83/173 (47%), Positives = 110/173 (63%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA FY + L+TDH F+ NFF DF +L + V I EK DFS++ AH E Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE--- 252 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K + EKKA + E+K +E + + + ++GR+E VGNFR+EPP LF GRG HP Sbjct: 253 -KLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 311 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+KRR+ E VTLNLG +A IPE P GH WG+I H++ VTWLA WK++I+ Sbjct: 312 TGKLKRRVVSEQVTLNLGKDAKIPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 363 [37][TOP] >UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH Length = 917 Score = 157 bits (396), Expect = 5e-37 Identities = 80/172 (46%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A +T++ K KFR NF+ D+R LL K SL+ CDF+ I EK Sbjct: 406 VATMFAVMRETEYYKKPKFRENFWNDWRKLLGKNHMIK---SLDDCDFTPIYEWYMQEKE 462 Query: 181 KKKAEKKAQTTAERKE-AREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 KK Q TAE K +E + ++ ++ A++DG E +GNFRVEPP LF GRG+HP Sbjct: 463 TKK-----QMTAEEKRIVKEEKLKQEEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEHPK 517 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 GK+K+RI+P D+T+N+G APIPECP+PG W ++ H++ VTWLA W D I Sbjct: 518 MGKLKKRIRPCDITINIGKEAPIPECPIPGERWKEVKHDNTVTWLAFWSDPI 569 [38][TOP] >UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FNH4_CANGA Length = 744 Score = 157 bits (396), Expect = 5e-37 Identities = 82/176 (46%), Positives = 113/176 (64%), Gaps = 3/176 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLED 171 VA F+A+ L TDH F+ NFF DF +L + T+ IT +KCDFS++ + E Sbjct: 159 VAGFFANLLHTDHAKNPVFQKNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFE- 217 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 KK EK+ + E+K+ + + + +F +DGR+E VGNFRVEPP+LF GRG H Sbjct: 218 ---LKKEEKRNMSREEKKQIKLEKDKFEEKFKFCELDGRKEQVGNFRVEPPDLFRGRGAH 274 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 P TGK+KRR+ PED+ LNL +APIP P GH+WG+I H++ V WLA WK++I G Sbjct: 275 PKTGKLKRRVYPEDIILNLSKDAPIPPAP-QGHHWGEIRHDNTVQWLAMWKENIFG 329 [39][TOP] >UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MGX0_9CHLO Length = 685 Score = 156 bits (395), Expect = 7e-37 Identities = 75/171 (43%), Positives = 108/171 (63%), Gaps = 1/171 (0%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKA 180 A F+A TD+ K+ F NF+ F+ +L A I +KCDF+++ HL Sbjct: 202 ANFFAVMKDTDYAQKDVFVKNFWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHL----- 256 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K++ +KKA + ++K+A+ A+ ++ A++DGR E VGNFRVEPP LF GRG+HP Sbjct: 257 KEREKKKAISNEDKKKAKAAKDAEEEKYNWAVIDGRRERVGNFRVEPPGLFRGRGEHPKM 316 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G++K+RI PED+T+N+G P P+ P PGH W +IHN VTWL GW D+I Sbjct: 317 GRIKKRIMPEDITINIGKGVPAPD-PGPGHKWKDVIHNDTVTWLCGWNDTI 366 [40][TOP] >UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IDM1_CHLRE Length = 586 Score = 155 bits (392), Expect = 2e-36 Identities = 77/173 (44%), Positives = 111/173 (64%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A +TD++ K+ F NF+ F+ +L VI L+KCDF+ I + H+ + Sbjct: 68 VATMFAVMKETDYMNKKVFLDNFWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQRE 124 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 AKK K+ E+ ++ + E+ ++ VA VDGR E VGNFRVEPP LF GRG+HP Sbjct: 125 AKKGISKE-----EKDRIKKEKDEKEAKYKVAYVDGRPEPVGNFRVEPPGLFRGRGEHPK 179 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GK+K+R+ P D+T+N+G N P+PE P PG W ++ H+ VTWLA WKD+I+ Sbjct: 180 MGKIKKRVYPRDITINIGENEPVPEHPYPGQTWKEVKHDHTVTWLAYWKDTIS 232 [41][TOP] >UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera RepID=UPI0000DB758E Length = 973 Score = 155 bits (391), Expect = 2e-36 Identities = 72/173 (41%), Positives = 111/173 (64%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L D+ K F SNFF D+R ++ +++ K++ L KC+F I A+ Sbjct: 482 VATFYARMLDHDYTTKPAFNSNFFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----I 536 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +K E+KA T E+++ +E E +++ ++DG +E +GNF++EPP LF GRG+HP Sbjct: 537 QKSEERKAMTKEEKQKIKEKNEEIQKEYGYCIIDGHKEKIGNFKIEPPGLFRGRGEHPKM 596 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+R+ PED+ +N ++ IP+ P PGH W +I H+ VTWLA W ++I G Sbjct: 597 GKLKKRVMPEDILINCSKDSNIPK-PPPGHKWKEIRHDPNVTWLASWTENIQG 648 [42][TOP] >UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N6Y9_COPC7 Length = 863 Score = 155 bits (391), Expect = 2e-36 Identities = 77/173 (44%), Positives = 109/173 (63%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174 VA FY + L+TDH F NFF DF+ +L + IT+ E CDF + + E E Sbjct: 297 VAGFYGALLETDHAKDATFNKNFFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAE 356 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 KAK+KA T E+K A++ + E ++ ++DGR+E VGNFR+EPP LF GRG+HP Sbjct: 357 KAKRKA----MTNEEKKAAKKKKDELEEKYKTCVMDGRKEKVGNFRIEPPGLFRGRGEHP 412 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+R+ PED+T+N+G A IP +PG W K+IH++ VTWLA W ++I Sbjct: 413 KKGSLKKRVYPEDITINIGKEAKIPVPNIPG-KWKKVIHDNTVTWLATWTENI 464 [43][TOP] >UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404 RepID=C5M985_CANTT Length = 777 Score = 154 bits (390), Expect = 3e-36 Identities = 81/173 (46%), Positives = 110/173 (63%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA FY + L+TDH F+ NFF DF +L + V I EK DFS++ A+ E ++ Sbjct: 195 VAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKEFEKMDFSKMYAYYEQQR 254 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 EKKA + E+K +E + + ++GR+E VGNFR+EPP LF GRG HP Sbjct: 255 E----EKKALSRDEKKRLKEERDKFEEPYKTCYLNGRKELVGNFRIEPPGLFRGRGAHPK 310 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+KRR+ PE VTLNLG +A +PE P GH WG+I H++ VTWLA WK++I+ Sbjct: 311 TGKLKRRVAPEQVTLNLGKDAKVPE-PPAGHQWGEIRHDNEVTWLAMWKENIS 362 [44][TOP] >UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans RepID=Q5KB99_CRYNE Length = 881 Score = 154 bits (388), Expect = 5e-36 Identities = 82/176 (46%), Positives = 111/176 (63%), Gaps = 3/176 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174 VA F+ + L+TD+ KFR NFF DF+A++ K + LEKCDF + + E E Sbjct: 298 VAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKE 357 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 351 K KKKA T E K+A +AE +++ + A VDGR+E VGNFR EPP LF GRG+H Sbjct: 358 KEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEH 412 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 P G VK R++PED+ +N+G APIP +PG W I H++ VTWLA WK+++ G Sbjct: 413 PKKGTVKNRLRPEDIIINIGKEAPIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNG 467 [45][TOP] >UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans RepID=O59891_CRYNE Length = 844 Score = 154 bits (388), Expect = 5e-36 Identities = 82/176 (46%), Positives = 111/176 (63%), Gaps = 3/176 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174 VA F+ + L+TD+ KFR NFF DF+A++ K + LEKCDF + + E E Sbjct: 261 VAGFFGALLETDYAQDAKFRENFFRDFKAIVEKYPPKEDVKVKKLEKCDFRPMFEYFEKE 320 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDH 351 K KKKA T E K+A +AE +++ + A VDGR+E VGNFR EPP LF GRG+H Sbjct: 321 KEKKKA-----LTKEEKKAIKAEKDKLEAPYLYANVDGRKEKVGNFRAEPPGLFKGRGEH 375 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 P G VK R++PED+ +N+G APIP +PG W I H++ VTWLA WK+++ G Sbjct: 376 PKKGTVKNRLRPEDIIINIGKEAPIPVPNIPG-QWKGIQHDNTVTWLAHWKENVNG 430 [46][TOP] >UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP RepID=B2WCA4_PYRTR Length = 905 Score = 153 bits (387), Expect = 6e-36 Identities = 85/181 (46%), Positives = 108/181 (59%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VATFY S L + H V F NFF DF A+L T K I EKCDF I Sbjct: 314 VATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKPIF 373 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E+AKKKA A+ A + E AEA+ + L DGR++ VGNFRVEPP LF Sbjct: 374 EWFDAERAKKKALSAAEKKALKAEKEAAEAD----YMYCLWDGRKQKVGNFRVEPPGLFR 429 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK+R+ PE +T+N+G NA +PE P GH W +I H+ TWLA W+++I Sbjct: 430 GRGEHPKTGRVKKRVMPEQITINIGENAKVPE-PPAGHRWKEIKHDHEGTWLAMWQENIN 488 Query: 517 G 519 G Sbjct: 489 G 489 [47][TOP] >UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA Length = 892 Score = 152 bits (384), Expect = 1e-35 Identities = 74/167 (44%), Positives = 106/167 (63%) Frame = +1 Query: 13 YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA 192 YA TD++ K++F+ NF+ D+R LL VI +L+ CDF+ I + EK KKK Sbjct: 386 YAVMRDTDYMQKDRFKENFWNDWRKLLGRNH---VIQNLKDCDFTPIYDWCQSEKEKKKQ 442 Query: 193 EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVK 372 TT E+K +E + ++ ++T A+VDG + VGNFRVEPP LF GRG+HP G++K Sbjct: 443 ----MTTEEKKALKEEKLKQEEKYTWAIVDGVKRRVGNFRVEPPGLFRGRGEHPKMGRLK 498 Query: 373 RRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 +RI P D+ +N+G A +PECP+PG W I +++ VTWL W D I Sbjct: 499 KRIHPSDIVINIGSEAQVPECPIPGEGWKDIRNDNTVTWLCYWSDPI 545 [48][TOP] >UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JVY3_SCHJY Length = 654 Score = 152 bits (384), Expect = 1e-35 Identities = 75/175 (42%), Positives = 106/175 (60%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDE 174 VA F+ + L++DH F+ NFF DF+A+ A K A + CDF + + E Sbjct: 279 VAGFFGALLESDHAQNPTFQKNFFRDFQAVCKEAGMKSADIPKEFNSCDFRPMFEYFESL 338 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 K KK K E+KE ++ + E +F L+DGR+E VGNFR+EPP LF GRG HP Sbjct: 339 KEAKKNMSKE----EKKELKKKKEEEEEKFKWCLLDGRKEKVGNFRIEPPGLFRGRGSHP 394 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 TG +KRR+ PE +T+N+G A +PE P+PGH W ++ H+ VTWLA W +++ G Sbjct: 395 KTGTLKRRVYPEQITINIGKGAKVPE-PLPGHKWAEVRHDDQVTWLAMWHENVNG 448 [49][TOP] >UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TJW1_VANPO Length = 799 Score = 152 bits (384), Expect = 1e-35 Identities = 79/175 (45%), Positives = 109/175 (62%), Gaps = 3/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEK---CDFSRIEAHLED 171 VA F+A+ L TDH F+ NFF DF+ +L + LEK CDFS++ + E Sbjct: 214 VAGFFAALLHTDHAKNTVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEI 273 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 ++ ++K + E+K+ R + E+ F +DGR E VGNFRVEPP+LF GRG H Sbjct: 274 QRE----QRKKLSPQEKKQLRLEKEEQEEPFKFCELDGRREQVGNFRVEPPDLFRGRGAH 329 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 P TGK+KRR+ PED+ LNL NAPIP P GH WG+I H++ V WLA W+++I+ Sbjct: 330 PKTGKLKRRVYPEDIVLNLDRNAPIPAVP-EGHKWGEIKHDNTVQWLAMWRENIS 383 [50][TOP] >UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E5D8 Length = 961 Score = 152 bits (383), Expect = 2e-35 Identities = 73/173 (42%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L D+ KEKF +NFF D+R ++ D K KVIT L KC+F + + ++ Sbjct: 460 VATFYAKMLTHDYTTKEKFNTNFFNDWRKVMTD-KERKVITDLSKCNFKPMALYFQE--- 515 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K E+KA + E+K ++ +++ +DG +E +GNFR+EPP LF GRG+HP Sbjct: 516 -KSEERKAMSKEEKKVIKDQNDAIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKM 574 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+R+ PEDV +N ++ IP+ P GH W K+ H+ VTWLA W +++ G Sbjct: 575 GMLKKRVLPEDVIINCSKDSKIPK-PPDGHKWKKVQHDPSVTWLASWTENVQG 626 [51][TOP] >UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio RepID=Q6T721_DANRE Length = 600 Score = 152 bits (383), Expect = 2e-35 Identities = 76/172 (44%), Positives = 110/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +ATFYA L ++ KE F+ NFF D+R + + K+IT+L KCDF+ I + + Sbjct: 92 IATFYAKMLDHEYTTKEVFQKNFFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE--- 147 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 KAE+K T E K+ + EA R+ +F L+DG E +GNF++EPP LF GRG+HP Sbjct: 148 --KAEEKKNMTKEEKQVLKDEAARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPK 205 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G++K+RIQPEDV +N ++ IPE P GH W ++ H++ VTWLA W ++I Sbjct: 206 MGRLKKRIQPEDVAINCSKDSKIPE-PPAGHKWKRVQHDNTVTWLASWLENI 256 [52][TOP] >UniRef100_A9T368 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T368_PHYPA Length = 502 Score = 152 bits (383), Expect = 2e-35 Identities = 75/168 (44%), Positives = 106/168 (63%), Gaps = 1/168 (0%) Frame = +1 Query: 13 YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKK 189 +A ++TD+ KE+F NF+ D++ L VI E CDF+ I + H A++K Sbjct: 2 FAVMIETDYAKKERFVKNFWDDWKPYLGKNH---VIKKFELCDFTPIFQWH-----AREK 53 Query: 190 AEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKV 369 KK + E+K +E + ++ A+VDG +E VGNFRVEPP LF GRGDHP GK+ Sbjct: 54 ERKKNMSAEEKKRLKEEKLAAEEKYMWAVVDGVKEKVGNFRVEPPGLFRGRGDHPKMGKL 113 Query: 370 KRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 K RI P D+ +N+G +AP+PECP+PG W ++ H++ VTWLA WKD I Sbjct: 114 KTRILPHDIVINIGKDAPVPECPIPGQKWKEVRHDNTVTWLAYWKDPI 161 [53][TOP] >UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FVE9_CANGA Length = 717 Score = 152 bits (383), Expect = 2e-35 Identities = 81/176 (46%), Positives = 109/176 (61%), Gaps = 3/176 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLED 171 VA F+A L+T H F+ NFF DF+ +L D T+ I S ++ DFS + D Sbjct: 132 VAGFFAHLLETPHAQNPVFQKNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHD 187 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 + K EKK+ T ++KE R + ++ +DGR E VGNF+VEPP+LF GRG H Sbjct: 188 YFVQLKEEKKSMTAMQKKEIRLEREKFEEKYKFCELDGRREQVGNFKVEPPDLFRGRGAH 247 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 P TGK+KRRI+PED+ LNLG APIP P GH WG+I H++ V WLA W+++I G Sbjct: 248 PKTGKLKRRIRPEDIVLNLGEGAPIPP-PPSGHQWGEIRHDNTVQWLAMWRENIFG 302 [54][TOP] >UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC 6260 RepID=UPI000151AE34 Length = 754 Score = 151 bits (382), Expect = 2e-35 Identities = 75/173 (43%), Positives = 110/173 (63%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+A+ L+TDH F+ NF+ DF ++ ++ A V + K DF+++ AH E Sbjct: 172 VAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE--- 228 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K +KK + E+K +EA+ + + L++GR+E VGNFRVEPP LF GRG HP Sbjct: 229 -MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPK 287 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+K+R+ PED+TLNL +PE P GH WG++ H++ V WLA WK++I+ Sbjct: 288 TGKLKKRVYPEDITLNLSKECKVPE-PPAGHKWGEVRHDNTVAWLAMWKENIS 339 [55][TOP] >UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii RepID=A5DLX4_PICGU Length = 754 Score = 151 bits (382), Expect = 2e-35 Identities = 75/173 (43%), Positives = 110/173 (63%), Gaps = 1/173 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+A+ L+TDH F+ NF+ DF ++ ++ A V + K DF+++ AH E Sbjct: 172 VAGFFAAMLETDHAQNPVFQKNFWNDFLQVVKESGGANVEMKDFTKADFTKMHAHFE--- 228 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K +KK + E+K +EA+ + + L++GR+E VGNFRVEPP LF GRG HP Sbjct: 229 -MLKEQKKNMSRDEKKALKEAKEKEEEPYKTCLLNGRKEQVGNFRVEPPGLFRGRGAHPK 287 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 TGK+K+R+ PED+TLNL +PE P GH WG++ H++ V WLA WK++I+ Sbjct: 288 TGKLKKRVYPEDITLNLSKECKVPE-PPAGHKWGEVRHDNTVAWLAMWKENIS 339 [56][TOP] >UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia vitripennis RepID=UPI00015B4D8F Length = 1019 Score = 151 bits (381), Expect = 3e-35 Identities = 72/173 (41%), Positives = 111/173 (64%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L+ D+ K+ F NFF D+R ++ +++ AK IT L+KC+F+ + + Sbjct: 512 VATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAK-ITDLKKCNFTEMHKYF----I 566 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K E+KA + E+K +E E +++ + +DG +E +GNF++EPP LF GRG+HP Sbjct: 567 MKSEERKAMSKEEKKAIKEKNDEIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHPKM 626 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+R+ PEDV +N ++ P+ P PGH W +I H+ VTWLA W ++I G Sbjct: 627 GKLKKRLVPEDVLINCSKDSVHPK-PPPGHKWKEIRHDPTVTWLASWTENIQG 678 [57][TOP] >UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299 RepID=C1FD86_9CHLO Length = 635 Score = 150 bits (380), Expect = 4e-35 Identities = 79/174 (45%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A TD+ K+ F NFF F+ L I +KCDF++I E+ Sbjct: 149 VATFFAVMKDTDYAQKDIFVKNFFDGFKKTLRGGPHG-FIKDFKKCDFTKIYMWNLQERE 207 Query: 181 KKK---AEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 +KK AE+K + AE+ A E ++ A +DGR E VGN++VEPP LF GRG+H Sbjct: 208 RKKSVSAEEKRKVKAEQAAAEE-------KYCWATIDGRRERVGNYKVEPPGLFRGRGEH 260 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 P G+VK+RI PED+ +N+G A +PE P+PGH W +IIHN+ VTWL GW D+I Sbjct: 261 PKMGRVKKRIMPEDIIINIGKGAKVPE-PLPGHKWKQIIHNNTVTWLCGWNDTI 313 [58][TOP] >UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UUB0_PHANO Length = 887 Score = 149 bits (376), Expect = 1e-34 Identities = 81/180 (45%), Positives = 106/180 (58%), Gaps = 8/180 (4%) Frame = +1 Query: 4 ATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEA 159 ATFY S L + H V F NFF DF A+L T K I EKCDF I Sbjct: 297 ATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDFKPIFE 356 Query: 160 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 339 H E ++A KKA A+ A + E AEAE + + DGR++ VGNFRVEPP LF G Sbjct: 357 HFEADRAAKKALPAAEKKALKAEKDAAEAE----YMFCMWDGRKQKVGNFRVEPPGLFRG 412 Query: 340 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 RG+HP TG++K+R+ PE +T+N+G NA +P P GH W ++ H+ TWLA W+++I G Sbjct: 413 RGEHPKTGRIKKRVAPEQITINIGENAKVPP-PPAGHRWKEVKHDHEGTWLAMWQENING 471 [59][TOP] >UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes RepID=TOP1M_PANTR Length = 601 Score = 148 bits (373), Expect = 2e-34 Identities = 76/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ A Sbjct: 92 VATFYGRMLGHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAA 150 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +K + E K+ + EAE++ R+F ++DG +E +GNF++EPP LF GRGDHP Sbjct: 151 ARKVLSR-----EEKQKLKEEAEKLQREFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPK 205 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W +S+ Sbjct: 206 MGMLKRRIMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 256 [60][TOP] >UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens RepID=TOP1M_HUMAN Length = 601 Score = 148 bits (373), Expect = 2e-34 Identities = 76/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ A Sbjct: 92 VATFYGRMLDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAA 150 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +K + E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP Sbjct: 151 ARKVLSR-----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPK 205 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W +S+ Sbjct: 206 MGMLKRRITPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 256 [61][TOP] >UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEP3_LACTC Length = 756 Score = 147 bits (370), Expect = 6e-34 Identities = 78/176 (44%), Positives = 110/176 (62%), Gaps = 4/176 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLED 171 VA F+A+ L++DH F+ NFF DF +L + K I E CDFS++ + + Sbjct: 171 VAGFFAALLESDHAQNPVFQKNFFNDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQL 230 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 348 +K +KK Q +++ K+ + E E+ + F +DGR+E VGNFR+EPP LF GRG Sbjct: 231 QKEQKK-----QLSSQEKKKLKIEKEQFEEPFKFCFLDGRKEQVGNFRIEPPGLFRGRGA 285 Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 HP TGK+KRR+ PEDV LNL A IP+ P GH WG+I H+S V WLA W+++I+ Sbjct: 286 HPKTGKLKRRVYPEDVVLNLDKEAEIPKAP-EGHKWGEIRHDSTVQWLAMWRENIS 340 [62][TOP] >UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO Length = 1043 Score = 146 bits (368), Expect = 9e-34 Identities = 70/173 (40%), Positives = 107/173 (61%), Gaps = 1/173 (0%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + K ++I KC+F + + + E K Sbjct: 537 ATFYAKMLNHDYCTKDVFNNNFFKDFRKTMTP-KEKEIIKDFRKCNFQEMFEYFQAESEK 595 Query: 184 KKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +KA T E K A++ E+E ++++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 596 RKA-----ATKEEKLAKKVESEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 650 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI DV++N G N+ +P+ P PG W ++ H++ VTWLA W +++ G Sbjct: 651 GMIKRRIAARDVSINCGKNSKVPQ-PPPGERWKEVRHDNTVTWLASWTENVQG 702 [63][TOP] >UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=UPI0001760D92 Length = 748 Score = 145 bits (366), Expect = 2e-33 Identities = 73/174 (41%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L+ ++ E FR NFF D+R + + +K IT L+KCDF+++ + Sbjct: 239 VATFYAKMLEHEYTTNEIFRKNFFKDWRKEMTSEEKSK-ITELKKCDFTQMHEYF----- 292 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + E ER+ Q + L+D E +GNFR+EPP LF GRGDHP Sbjct: 293 KAQSEARKQMSKEEKQKNKEENERILQEYGFCLMDNHRERIGNFRIEPPGLFRGRGDHPK 352 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWL W ++I G Sbjct: 353 MGKLKRRIRPEDIIINCSKDSVQPKAP-PGTRWKEVRHDNKVTWLVSWTENIQG 405 [64][TOP] >UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BE191 Length = 789 Score = 145 bits (366), Expect = 2e-33 Identities = 76/173 (43%), Positives = 106/173 (61%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+ + +TDH F+ NFF DF +L D V I + DFS++ AH E + Sbjct: 207 VAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLR 266 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 +KK K + K+A +AE ++ + + L++G +E VGNFR+EPP LF GRG HP Sbjct: 267 DQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHP 321 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 TGK+KRR+ PEDVTLNL IPE P GH W ++ H++ V+WLA WK++I Sbjct: 322 KTGKLKRRVMPEDVTLNLSEGCKIPE-PPQGHKWAEVRHDNTVSWLAMWKENI 373 [65][TOP] >UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi RepID=A8Q2Z1_BRUMA Length = 751 Score = 145 bits (366), Expect = 2e-33 Identities = 68/173 (39%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA+FYA L+ ++ K+ F NFF D+R ++ + K IT L KCDF + H Sbjct: 252 VASFYAKILEHEYTTKDIFNKNFFTDWRKVMTPAEREK-ITDLTKCDFREMHDHY----I 306 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K + E+++ + E+++ +E + E + + VA +DG ++ +GNFR+EPP+LF GRG HP Sbjct: 307 KLREERRSLSKEEKQKLKEIKQEEAKIYGVAYIDGHKQKIGNFRIEPPDLFRGRGGHPKM 366 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G++K+R+ PEDV +N ++ IP+ P GH W ++ H++ VTWL W D+I G Sbjct: 367 GRLKKRVNPEDVIINCSKDSEIPK-PPEGHRWKEVRHDNTVTWLCSWTDNILG 418 [66][TOP] >UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA Length = 789 Score = 145 bits (366), Expect = 2e-33 Identities = 76/173 (43%), Positives = 106/173 (61%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 177 VA F+ + +TDH F+ NFF DF +L D V I + DFS++ AH E + Sbjct: 207 VAGFFGAMAETDHAKNPTFQKNFFEDFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLR 266 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 +KK K + K+A +AE ++ + + L++G +E VGNFR+EPP LF GRG HP Sbjct: 267 DQKKLLSK-----DEKKAIKAEKDKFEEPYKTCLLNGHKEQVGNFRIEPPGLFRGRGAHP 321 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 TGK+KRR+ PEDVTLNL IPE P GH W ++ H++ V+WLA WK++I Sbjct: 322 KTGKLKRRVMPEDVTLNLSEGCKIPE-PPQGHKWAEVRHDNTVSWLAMWKENI 373 [67][TOP] >UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7Q9Y0_IXOSC Length = 499 Score = 145 bits (365), Expect = 2e-33 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FY L D+ KE F NFF D+R + K A++IT L KC+F I+ + Sbjct: 270 VAGFYGRMLDHDYTSKEAFNKNFFKDWRKTMTP-KEAELITDLSKCNFKEIDVYY----- 323 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K+K+E++ + E K+A +A+ E++ ++ ++DG + +GNF++EPP LF GRG+HP Sbjct: 324 KQKSEERKAMSKEEKQAIKAQNEKLLEEYGFCIIDGHRQKIGNFKIEPPGLFRGRGEHPK 383 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRR+ PEDV +N+G A IP P GH W ++ H++ V+WL+ W ++I G Sbjct: 384 MGMLKRRVMPEDVIINIGKEAKIPP-PPEGHRWKEVRHDNTVSWLSSWTENILG 436 [68][TOP] >UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO Length = 732 Score = 145 bits (365), Expect = 2e-33 Identities = 74/175 (42%), Positives = 111/175 (63%), Gaps = 3/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV---ITSLEKCDFSRIEAHLED 171 VA F+A+ LQ+DH F+ NFF DF ++L A+ I KCDFS++ A+++ Sbjct: 147 VAGFFAALLQSDHAQNPVFQKNFFEDFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQ 206 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 ++ + K ++ ERK ++ + + V L+ GR+E V F+++PP+LF GRG H Sbjct: 207 QRV----QMKQLSSHERKLLKQEKGQTEGPVQVLLLTGRKEQVDTFKIDPPDLFRGRGAH 262 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 P TGK+KRR+QPEDV LNL +APIPE P GH WG+I H++ V WL W+++I+ Sbjct: 263 PKTGKLKRRVQPEDVVLNLDKDAPIPE-PPAGHKWGEIRHDNTVQWLCMWRENIS 316 [69][TOP] >UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA Length = 909 Score = 144 bits (364), Expect = 3e-33 Identities = 73/167 (43%), Positives = 108/167 (64%), Gaps = 1/167 (0%) Frame = +1 Query: 22 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKK 201 ++ T+++ K FR N D++ +L +I +L+ CDF+ I E + K EKK Sbjct: 395 QILTEYLTKPVFRENVMNDWKIILGRNH---IIKNLDDCDFTPIY-----EWFRLKKEKK 446 Query: 202 AQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRR 378 Q +AE K+A +E + ++ ++ A+VDG +E VGNFRVEPP LF GR P GK+K+R Sbjct: 447 KQMSAEEKKAVKEEKLKQEEKYMWAVVDGVKENVGNFRVEPPGLFRGRESIPKMGKLKKR 506 Query: 379 IQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 I P D+T+N+G +APIPECP+PG +W ++ H++ VTWLA W D I G Sbjct: 507 ISPSDITINIGKDAPIPECPIPGESWKEVRHDNTVTWLAYWNDPING 553 [70][TOP] >UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187DC43 Length = 343 Score = 144 bits (363), Expect = 4e-33 Identities = 79/173 (45%), Positives = 105/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIEAHLEDE 174 VA FYA+ ++TDH F NFF D+ +L D I T +KCDF + + E E Sbjct: 20 VAGFYAALIETDHAQDAAFNKNFFEDWLKVLQDHPPCNGIKATDFDKCDFRPMYEYFEAE 79 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 KAKKKA A+ +K+ EAEA+ +F +DGR+E VGNFRVEPP LF GRG+HP Sbjct: 80 KAKKKATSAAEKKEIKKQKDEAEAKYTHRF----LDGRKEKVGNFRVEPPGLFRGRGEHP 135 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K R+ PED+ LN+G +AP P +PG W I H++ VTWLA ++I Sbjct: 136 KKGSLKYRVCPEDIALNIGKDAPTPIPNIPG-KWKAIQHDNTVTWLATRTENI 187 [71][TOP] >UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1 Tax=Tribolium castaneum RepID=UPI00017582B6 Length = 936 Score = 144 bits (363), Expect = 4e-33 Identities = 69/172 (40%), Positives = 109/172 (63%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA+FY+ L D+ KE F +NFF D+R ++++++ KVI L+KC+F + A+ D Sbjct: 429 VASFYSKMLDHDYTTKEVFNNNFFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMD--- 484 Query: 181 KKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 AEK T E K+A +E ++++ +DG +E +GNF++EPP LF GRG+HP Sbjct: 485 --LAEKNRNRTKEEKQALKEKNEALIKEYGFCNIDGHKEKIGNFKIEPPGLFRGRGEHPK 542 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRR++ ED+ +N ++ IPE P PGH W ++ H+ VTWLA W +++ Sbjct: 543 MGMLKRRVEAEDIIINCSQDSKIPE-PPPGHKWKEVRHDDNVTWLASWTENV 593 [72][TOP] >UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus RepID=UPI00017968A4 Length = 655 Score = 144 bits (362), Expect = 5e-33 Identities = 74/172 (43%), Positives = 108/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY L ++ KE F++NFF+D+R + + K+I L+KCDF+ I + D+ A Sbjct: 146 VATFYGKMLDHEYTTKEVFQNNFFSDWRKEMTAEE-RKIIKHLDKCDFTEIHRYFVDKTA 204 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +KA + E K+ + EAE+++Q F +DG E +GNF+ EPP LF GRGDHP Sbjct: 205 ARKALSR-----EEKQKLKEEAEKLQQEFGYCTLDGHREKIGNFKTEPPGLFRGRGDHPK 259 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDVT+N ++ IP+ P GH W ++ ++ VTWLA W ++I Sbjct: 260 MGMLKRRILPEDVTINCSRDSKIPK-PPAGHQWKEVRSDNTVTWLASWTENI 310 [73][TOP] >UniRef100_B8CC91 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8CC91_THAPS Length = 536 Score = 144 bits (362), Expect = 5e-33 Identities = 68/153 (44%), Positives = 97/153 (63%) Frame = +1 Query: 55 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 234 F NFF DFR +L +I +KCDF I+ HL ++K +KA T ERK + Sbjct: 12 FIKNFFTDFRTILGKNH---IIKDFKKCDFGPIQRHLNEQKLIRKAI----TDEERKVNK 64 Query: 235 EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 414 +++ E + +F ALVDG E VGN+ +EPP F GRG+HP GK+K+R++PE V +N+ Sbjct: 65 DSKNETLFKFGYALVDGHLEKVGNYNMEPPGAFRGRGEHPKMGKLKQRVEPEQVMINVSE 124 Query: 415 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 +AP+P C VPGH WG++ H+ V WL WK++I Sbjct: 125 DAPVPMCSVPGHAWGEVRHDPTVQWLCQWKENI 157 [74][TOP] >UniRef100_A4S5R8 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901 RepID=A4S5R8_OSTLU Length = 491 Score = 144 bits (362), Expect = 5e-33 Identities = 73/161 (45%), Positives = 97/161 (60%) Frame = +1 Query: 31 TDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 210 +D+ K F NF F+A L + A IT KCDF+++ H + KKK T Sbjct: 4 SDYATKPVFVKNFMDGFKAALKNGPHA-FITDFSKCDFTKMYMHFLAIREKKKE----MT 58 Query: 211 TAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPE 390 + E+K + + +T A +DGR E VGNFRVEPP LF GRG+HP GK+KRR+ PE Sbjct: 59 SEEKKRIKAQKDIDEEPYTWATIDGRREKVGNFRVEPPGLFRGRGEHPKMGKIKRRVVPE 118 Query: 391 DVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 D+T+N+G +A +PE P GH+W +IHN TWLAGW D I Sbjct: 119 DITINIGKDAKVPE-PPAGHSWKAVIHNDTATWLAGWNDVI 158 [75][TOP] >UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN Length = 990 Score = 144 bits (362), Expect = 5e-33 Identities = 68/172 (39%), Positives = 104/172 (60%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + + + E K Sbjct: 498 ATFYAKMLNHDYCTKDVFNTNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEK 556 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + A++ E V+++ ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 557 RKAATKEEKLAKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 612 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G + +P P PG W ++ H++ VTWLA W +++ G Sbjct: 613 MIKRRIQASDVSINCGKESHVPS-PPPGQRWKEVRHDNTVTWLASWIENVQG 663 [76][TOP] >UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B1 Length = 751 Score = 143 bits (361), Expect = 6e-33 Identities = 73/173 (42%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA Sbjct: 242 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KA 297 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A +KA T E+ + +E ++QF ++D +E + NFR+EPP LF GRGDHP Sbjct: 298 QTEA-RKAMTKEEKLKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 356 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ PE P PG W ++ H++ VTWL W ++I G Sbjct: 357 GMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQG 408 [77][TOP] >UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B0 Length = 751 Score = 143 bits (361), Expect = 6e-33 Identities = 73/173 (42%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA Sbjct: 242 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KA 297 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A +KA T E+ + +E ++QF ++D +E + NFR+EPP LF GRGDHP Sbjct: 298 QTEA-RKAMTKEEKLKIKEENERILQQFGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 356 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ PE P PG W ++ H++ VTWL W ++I G Sbjct: 357 GMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKVTWLVSWTENIQG 408 [78][TOP] >UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA Length = 763 Score = 143 bits (361), Expect = 6e-33 Identities = 71/172 (41%), Positives = 106/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEK-FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 177 VA F+ + L ++ +K F+ NFF DF+ T + E CDF+ + + E Sbjct: 181 VAGFFGAILSSEQYVKNPTFQKNFFHDFQETCKKTNAPVIPEKFEYCDFTPMFEYFE--- 237 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 KKK EKK ++ E+K+ +E + ++ +DGR+E VGNFR+EPP LF GRGDHP Sbjct: 238 -KKKEEKKNKSKEEKKKIKEEKDALEEKYKYCFLDGRKEKVGNFRIEPPGLFRGRGDHPK 296 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 TGK+K R+ PE V +N+G ++ IP P PGHNW ++ H++ VTWLA W +++ Sbjct: 297 TGKLKTRVVPEQVIINIGKDSVIPS-PPPGHNWKEVRHDNTVTWLATWNENV 347 [79][TOP] >UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732 RepID=C5DTC9_ZYGRC Length = 843 Score = 143 bits (361), Expect = 6e-33 Identities = 78/176 (44%), Positives = 110/176 (62%), Gaps = 4/176 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLED 171 VA F+A+ LQ+DH F+SNFF DF +L + TK I S +KCDF+++ E Sbjct: 258 VAGFFAALLQSDHAKNTVFQSNFFNDFIEVLNENGGTKNGINIESFDKCDFTKMFEFFEM 317 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGD 348 +K ++K Q + + K+ E E+ + F +DGR+E VGNF++EPP LF GRG Sbjct: 318 QKEQRK-----QLSPQEKKQLRMEREKFEEPFKYCELDGRKEQVGNFKIEPPGLFRGRGA 372 Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 HP TGK+KRR+ PEDV LNL +A IP P G WG+I H++ V WLA W+++I+ Sbjct: 373 HPKTGKLKRRVYPEDVVLNLDKDATIPPLP-EGQKWGEIRHDNTVQWLAMWRENIS 427 [80][TOP] >UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y3I3_PHATR Length = 594 Score = 142 bits (359), Expect = 1e-32 Identities = 71/153 (46%), Positives = 92/153 (60%) Frame = +1 Query: 55 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 234 F NFFADFR +L K +KCDF I HL ++K +KA T ERK + Sbjct: 78 FIKNFFADFREILGKKHIVK---EFKKCDFEPIRKHLNEQKIIRKAI----TDEERKANK 130 Query: 235 EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGP 414 E ++ + QF ++VDG E VGNF +EPP F GRG+HP GK+K R+ PE V+LNL Sbjct: 131 EDRSQTLHQFGFSIVDGHIERVGNFNMEPPGAFRGRGEHPKMGKLKSRVLPEQVSLNLSE 190 Query: 415 NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 AP+P CPVPGH W + H+ WLA WK++I Sbjct: 191 CAPVPPCPVPGHAWSDVRHDPRGQWLATWKENI 223 [81][TOP] >UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC Length = 884 Score = 142 bits (359), Expect = 1e-32 Identities = 77/181 (42%), Positives = 107/181 (59%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VA F+ L T HV F+ NFF DFR +L T AK I KCDF I Sbjct: 293 VAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQPIF 352 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 A+ ++++ EKKA AE+K + + + + + DGR++ VGNFRVEPP LF Sbjct: 353 AYYDNQRQ----EKKALPPAEKKRLKAEKDAQEAPYMFCMWDGRKQKVGNFRVEPPALFR 408 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W+++I Sbjct: 409 GRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 467 Query: 517 G 519 G Sbjct: 468 G 468 [82][TOP] >UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792028 Length = 1011 Score = 142 bits (358), Expect = 1e-32 Identities = 68/173 (39%), Positives = 104/173 (60%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L+ D+ KE F NF D+R + K ++IT L C+F + + Sbjct: 240 VATFYAKMLEHDYTTKEVFNKNFLKDWRKTMTP-KEKELITDLSLCNFKEMNVYF----T 294 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KK E+KA + E+K+ +E +++ +DG +E +GNF++EPP LF GRG+HP Sbjct: 295 KKSEERKAMSKEEKKKIKEENEALQKEYGFCTIDGHKEKIGNFKIEPPGLFRGRGEHPKM 354 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+R+ PEDV +N ++ IP+ P PGH W ++ H+ VTWLA W +++ G Sbjct: 355 GMLKKRVVPEDVLINCSKDSNIPK-PPPGHKWKEVRHDFGVTWLASWIENVQG 406 [83][TOP] >UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5C65 Length = 755 Score = 142 bits (358), Expect = 1e-32 Identities = 71/173 (41%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA Sbjct: 246 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KA 301 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A +KA T E+ + +E ++Q+ ++D +E + NFR+EPP LF GRGDHP Sbjct: 302 QSEA-RKAMTKEEKLKIKEENERLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 360 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+P+D+ +N ++ PE P PG W ++ H++ VTWL W ++I G Sbjct: 361 GMLKRRIRPQDIIINCSKDSKYPE-PPPGTKWKEVRHDNKVTWLVSWTENIQG 412 [84][TOP] >UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU Length = 753 Score = 142 bits (358), Expect = 1e-32 Identities = 71/173 (41%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA Sbjct: 244 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KA 299 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A +KA T E+ + +E ++Q+ ++D +E + NFR+EPP LF GRGDHP Sbjct: 300 QSEA-RKAMTKEEKLKIKEENERLLQQYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 358 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+P+D+ +N ++ PE P PG W ++ H++ VTWL W ++I G Sbjct: 359 GMLKRRIRPQDIIINCSKDSKYPE-PPPGTKWKEVRHDNKVTWLVSWTENIQG 410 [85][TOP] >UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR Length = 881 Score = 142 bits (358), Expect = 1e-32 Identities = 78/181 (43%), Positives = 108/181 (59%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 156 VA F+ S L T HV F+ NFF DF+ +L D+K KV I KCDF I Sbjct: 290 VAGFFGSMLNATQHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIF 349 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 A+ + K+ EKK AE+K + + + + DGR++ VGNFRVEPP+LF Sbjct: 350 AYYD----MKRLEKKNLPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFR 405 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W+++I Sbjct: 406 GRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 464 Query: 517 G 519 G Sbjct: 465 G 465 [86][TOP] >UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HDT9_CHAGB Length = 907 Score = 142 bits (358), Expect = 1e-32 Identities = 79/181 (43%), Positives = 107/181 (59%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VATF+ S L T +V F+ NFFADF+ +L T AK I +K DF++I Sbjct: 312 VATFFGSMLHSTQNVENPVFQKNFFADFKDILKKTGGAKDKQGKPVDIKEFKKLDFTKIF 371 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 H + +KA A+ AE+ E +AE F DGR+E VGNFRVEPP LF Sbjct: 372 DHYKALGDARKARPAAEKKAEKAEKDKAEGH----FMFCKWDGRKEKVGNFRVEPPGLFR 427 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG VK+R+ PE VT+N+G +A +P P PGH W + H++ TWLA W++++ Sbjct: 428 GRGEHPKTGTVKKRVMPEQVTINIGKDAKVP-APPPGHKWKAVQHDNKATWLAMWQENVN 486 Query: 517 G 519 G Sbjct: 487 G 487 [87][TOP] >UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2 Length = 745 Score = 142 bits (358), Expect = 1e-32 Identities = 72/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171 VA F+A+ L++DH F+ NFF DF +L ++ I +CDF+++ + + Sbjct: 160 VAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ- 218 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 +K +KK T+ E+K+ R + + +DGR E VGNF+VEPP+LF GRG H Sbjct: 219 ---LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAH 275 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 P TGK+KRR+ PED+ LNL +AP+P P GH WG+I H++ V WLA W+++I Sbjct: 276 PKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENI 328 [88][TOP] >UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FTA8_NANOT Length = 896 Score = 142 bits (358), Expect = 1e-32 Identities = 75/181 (41%), Positives = 109/181 (60%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEK-FRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA+ + + L + H ++ F+ NFF DF+A++ T AK + KCDF I Sbjct: 305 VASHFGTMLNSTHNVENPVFQKNFFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVPIF 364 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 H E K +A+KKA T AE+K A+ + + + DGR++ VGNFRVEPP LF Sbjct: 365 EHHE----KLRAQKKAMTAAEKKAAKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 420 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W++++ Sbjct: 421 GRGEHPKTGTVKTRVQPEQITINIGKDAPVP-APPEGHRWKEVRHDQEGTWLAMWQENVN 479 Query: 517 G 519 G Sbjct: 480 G 480 [89][TOP] >UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JVV4_UNCRE Length = 889 Score = 142 bits (358), Expect = 1e-32 Identities = 78/181 (43%), Positives = 105/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A++ T AK I +KCDF I Sbjct: 316 VAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIF 375 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E K+ EKKA AERK + + + + DGR++ VGNFRVEPP LF Sbjct: 376 EYYE----MKRLEKKALPAAERKRLKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 431 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P PGH W ++ H+ TWLA W+++I Sbjct: 432 GRGEHPKTGRVKTRVQPEQITINIGKGAAVPP-PPPGHKWKEVKHDQEGTWLAMWQENIN 490 Query: 517 G 519 G Sbjct: 491 G 491 [90][TOP] >UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8MY66_ASPFN Length = 881 Score = 142 bits (358), Expect = 1e-32 Identities = 78/181 (43%), Positives = 108/181 (59%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 156 VA F+ S L T HV F+ NFF DF+ +L D+K KV I KCDF I Sbjct: 290 VAGFFGSMLNATQHVENPTFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIF 349 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 A+ + K+ EKK AE+K + + + + DGR++ VGNFRVEPP+LF Sbjct: 350 AYYD----MKRLEKKNLPPAEKKRLKAEKDAEEAPYMYCMWDGRKQKVGNFRVEPPSLFR 405 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W+++I Sbjct: 406 GRGEHPKTGRVKSRVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 464 Query: 517 G 519 G Sbjct: 465 G 465 [91][TOP] >UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae RepID=B3LJ50_YEAS1 Length = 769 Score = 142 bits (358), Expect = 1e-32 Identities = 72/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171 VA F+A+ L++DH F+ NFF DF +L ++ I +CDF+++ + + Sbjct: 184 VAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ- 242 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 +K +KK T+ E+K+ R + + +DGR E VGNF+VEPP+LF GRG H Sbjct: 243 ---LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAH 299 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 P TGK+KRR+ PED+ LNL +AP+P P GH WG+I H++ V WLA W+++I Sbjct: 300 PKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENI 352 [92][TOP] >UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae RepID=TOP1_YEAST Length = 769 Score = 142 bits (358), Expect = 1e-32 Identities = 72/174 (41%), Positives = 107/174 (61%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171 VA F+A+ L++DH F+ NFF DF +L ++ I +CDF+++ + + Sbjct: 184 VAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQ- 242 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 +K +KK T+ E+K+ R + + +DGR E VGNF+VEPP+LF GRG H Sbjct: 243 ---LQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAH 299 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 P TGK+KRR+ PED+ LNL +AP+P P GH WG+I H++ V WLA W+++I Sbjct: 300 PKTGKLKRRVNPEDIVLNLSKDAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENI 352 [93][TOP] >UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL Length = 886 Score = 142 bits (357), Expect = 2e-32 Identities = 77/181 (42%), Positives = 106/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L T HV F+ NFF+DF+ +L T AK I KCDF I Sbjct: 295 VAGFFGSMLNATQHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQSIF 354 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 A+ + K+ EK+ AE+K + + + L DGR++ VGNFRVEPP+LF Sbjct: 355 AYYD----AKRIEKRNIPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPSLFR 410 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G AP+P P GH W ++ H+ TWLA W+++I Sbjct: 411 GRGEHPKTGRVKARVQPEQITINIGKGAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 469 Query: 517 G 519 G Sbjct: 470 G 470 [94][TOP] >UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MH68_TALSN Length = 864 Score = 141 bits (356), Expect = 2e-32 Identities = 76/181 (41%), Positives = 105/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF+A+L T AK I KCDF I Sbjct: 273 VAGFFGSMLNSTHNVENPTFQKNFFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKPIF 332 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + K+ EKKA + AE+K + + + + DGR++ VGNFRVEPP LF Sbjct: 333 EYYD----AKRLEKKAMSAAEKKALKAEKDAAEAPYMYCMWDGRKQKVGNFRVEPPGLFR 388 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W++++ Sbjct: 389 GRGEHPKTGKVKTRVQPEQITINIGKEAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVN 447 Query: 517 G 519 G Sbjct: 448 G 448 [95][TOP] >UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR Length = 767 Score = 141 bits (356), Expect = 2e-32 Identities = 66/173 (38%), Positives = 106/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + VIT+L KCDF+++ + +D+ Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSE 316 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +K K E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 317 ARKQMSKE----EKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 372 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424 [96][TOP] >UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus RepID=TOP1M_RAT Length = 593 Score = 141 bits (356), Expect = 2e-32 Identities = 73/172 (42%), Positives = 105/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY L + KE FR NFF+D++ + + K+IT L+KCDFS I H + Sbjct: 85 VATFYGKMLHLECTTKEVFRRNFFSDWQKEMTAEE-RKLITHLDKCDFSEIHRHFME--- 140 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +AE + E+K+ + EAE+++Q F ++DG E +GNF+ EPP LF GRGDHP Sbjct: 141 --RAEARRTLPREQKQKLKEEAEKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 198 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRR+ PEDV +N ++ IPE P GH W ++ ++ V WLA W ++I Sbjct: 199 MGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAWVENI 249 [97][TOP] >UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG Length = 622 Score = 141 bits (355), Expect = 3e-32 Identities = 73/177 (41%), Positives = 104/177 (58%), Gaps = 4/177 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 168 VA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I +A +E Sbjct: 82 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 140 Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348 K K EK RK +EA + + ++ L+D E +GNF++EPP LF GRG+ Sbjct: 141 ARKNMSKEEKLVCNIQFRKVLKEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGE 200 Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 HP GK+K+RIQPEDV +N + IP P GH W ++ H++ VTWLA W ++I G Sbjct: 201 HPKQGKLKKRIQPEDVIINCSKESRIP-VPPAGHRWKEVRHDNTVTWLASWTENIQG 256 [98][TOP] >UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster RepID=Q8IR39_DROME Length = 581 Score = 141 bits (355), Expect = 3e-32 Identities = 67/172 (38%), Positives = 103/172 (59%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E K Sbjct: 89 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 147 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 148 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 203 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 204 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 254 [99][TOP] >UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster RepID=Q494M1_DROME Length = 974 Score = 141 bits (355), Expect = 3e-32 Identities = 67/172 (38%), Positives = 103/172 (59%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E K Sbjct: 482 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 540 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 541 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 596 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 597 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 647 [100][TOP] >UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME Length = 581 Score = 141 bits (355), Expect = 3e-32 Identities = 67/172 (38%), Positives = 103/172 (59%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E K Sbjct: 89 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 147 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 148 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 203 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 204 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 254 [101][TOP] >UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=B5DMS2_DROPS Length = 1054 Score = 141 bits (355), Expect = 3e-32 Identities = 69/173 (39%), Positives = 106/173 (61%), Gaps = 1/173 (0%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + + + E Sbjct: 548 ATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE--- 603 Query: 184 KKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +EK+ Q T E K A++ E E ++++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 604 --SEKRKQATKEEKLAKKNENEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 661 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI DV++N G + +P P PG W ++ H++ VTWLA W +++ G Sbjct: 662 GMIKRRIGASDVSINCGKESKVPP-PPPGSRWKEVRHDNTVTWLASWIENVQG 713 [102][TOP] >UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE Length = 1042 Score = 141 bits (355), Expect = 3e-32 Identities = 69/173 (39%), Positives = 106/173 (61%), Gaps = 1/173 (0%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + +K ++I KC+F + + + E Sbjct: 536 ATFYAKMLNHDYCTKDIFNNNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHEYFQAE--- 591 Query: 184 KKAEKKAQTTAERKEAREAEAER-VRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +EK+ Q T E K A++ E E ++++ ++DG +E +GNFR+EPP LF GRG+HP Sbjct: 592 --SEKRKQATKEEKLAKKNENEALIKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKM 649 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI DV++N G + +P P PG W ++ H++ VTWLA W +++ G Sbjct: 650 GMIKRRIGASDVSINCGKESKVPP-PPPGSRWKEVRHDNTVTWLASWIENVQG 701 [103][TOP] >UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6R590_AJECN Length = 651 Score = 141 bits (355), Expect = 3e-32 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + ++ AK + S EKCDF I Sbjct: 318 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIF 377 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E + EKK+ +AE+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 378 EYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 433 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P PGH W +I H+ TWLA W++++ Sbjct: 434 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEIKHDQEGTWLAMWQENVN 492 Query: 517 G 519 G Sbjct: 493 G 493 [104][TOP] >UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster RepID=TOP1_DROME Length = 972 Score = 141 bits (355), Expect = 3e-32 Identities = 67/172 (38%), Positives = 103/172 (59%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + + ++I KC+F + + + E K Sbjct: 480 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEK 538 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 539 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 594 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G ++ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 595 MIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 645 [105][TOP] >UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus RepID=UPI0000ECD01B Length = 593 Score = 140 bits (354), Expect = 4e-32 Identities = 70/172 (40%), Positives = 107/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ Sbjct: 84 IATFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNE 142 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +KA K E K+ + EA+++++ + ++DG E +GNF+ EPP LF GRGDHP Sbjct: 143 ARKALSK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 197 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI PEDV +N ++ IPE PV GH W ++ ++ VTWLA W ++I Sbjct: 198 MGMLKKRIMPEDVIINCSKDSKIPEPPV-GHKWKEVRFDNTVTWLASWTENI 248 [106][TOP] >UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus RepID=Q6T722_CHICK Length = 593 Score = 140 bits (354), Expect = 4e-32 Identities = 70/172 (40%), Positives = 107/172 (62%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ Sbjct: 84 IATFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNE 142 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +KA K E K+ + EA+++++ + ++DG E +GNF+ EPP LF GRGDHP Sbjct: 143 ARKALSK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 197 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI PEDV +N ++ IPE PV GH W ++ ++ VTWLA W ++I Sbjct: 198 MGMLKKRIMPEDVIINCSKDSKIPEPPV-GHKWKEVRFDNTVTWLASWTENI 248 [107][TOP] >UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA Length = 785 Score = 140 bits (354), Expect = 4e-32 Identities = 75/175 (42%), Positives = 107/175 (61%), Gaps = 3/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLED 171 VA F+A+ L++DHV F+ NF DF +L + A+ I K DF++I + + Sbjct: 200 VAGFFAAILESDHVKIPTFQKNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQV 259 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 +K +KK + E+K+ R + E + + +DGR E VGNFR+EPP LF GRG H Sbjct: 260 QKE----QKKQLSPQEKKQLRLEKEELEKPYKFCEIDGRVEQVGNFRIEPPGLFRGRGAH 315 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 P GK+KRR+ PEDV LNL APIPE P GH WG+I H++ V WL+ W+++I+ Sbjct: 316 PKNGKLKRRVYPEDVVLNLDKEAPIPE-PPKGHKWGEIRHDNTVQWLSMWRENIS 369 [108][TOP] >UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QNQ2_PENMQ Length = 860 Score = 140 bits (354), Expect = 4e-32 Identities = 76/181 (41%), Positives = 108/181 (59%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VA F+ + L + H V F+ NFF DF+A+L T AK I +KCDF I Sbjct: 269 VAGFFGAMLNSTHNVENPTFQKNFFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIF 328 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E ++ +KK A+ A + E EAEA + + DGR++ VGNFRVEPP+LF Sbjct: 329 EYYEGKRLEKKNLSAAEKKALKAERDEAEAP----YMYCIWDGRKQKVGNFRVEPPSLFR 384 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G +A +P P GH W ++ H+ TWLA W++++ Sbjct: 385 GRGEHPKTGKVKTRVMPEQITINIGKDAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVN 443 Query: 517 G 519 G Sbjct: 444 G 444 [109][TOP] >UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=O17966-2 Length = 734 Score = 140 bits (354), Expect = 4e-32 Identities = 70/173 (40%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A FYA L ++ KE F NF D+R ++ + + I L+KCDF I+A+ ++++ Sbjct: 226 IAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQRE 284 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +KA K + + KE +EAE V+ + +A++DG + V NFR+EPP +F GRG HP Sbjct: 285 IRKAMTKEEKL-KIKEEKEAE---VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKM 340 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+RI PEDV +N G + IP+ P PGH W ++ H++ VTWL W +S+ G Sbjct: 341 GLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVRHDNTVTWLCSWTESVLG 392 [110][TOP] >UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL Length = 806 Score = 140 bits (354), Expect = 4e-32 Identities = 70/173 (40%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A FYA L ++ KE F NF D+R ++ + + I L+KCDF I+A+ ++++ Sbjct: 298 IAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER-IHDLKKCDFRAIDAYQKEQRE 356 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +KA K + + KE +EAE V+ + +A++DG + V NFR+EPP +F GRG HP Sbjct: 357 IRKAMTKEEKL-KIKEEKEAE---VKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKM 412 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+RI PEDV +N G + IP+ P PGH W ++ H++ VTWL W +S+ G Sbjct: 413 GLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVRHDNTVTWLCSWTESVLG 464 [111][TOP] >UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI Length = 997 Score = 140 bits (353), Expect = 5e-32 Identities = 66/172 (38%), Positives = 103/172 (59%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + D + ++I KC+F + + E + Sbjct: 491 ATFYAKMLNHDYCTKDVFNTNFFKDFRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAESER 549 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + A++ E V+++ ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 550 RKAATKDEKLAKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 605 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRI +V++N G N+ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 606 MIKRRIGASEVSINCGKNSKVP-TPPPGQRWKEVRHDNTVTWLASWVENVQG 656 [112][TOP] >UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER Length = 969 Score = 140 bits (353), Expect = 5e-32 Identities = 68/172 (39%), Positives = 102/172 (59%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + +K ++I KC F+ + + E K Sbjct: 477 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFNEMFNFFQAESEK 535 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 536 RKAATKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 591 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G + +P P PG W ++ H++ VTWLA W +++ G Sbjct: 592 MIKRRIQASDVSINCGKESKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 642 [113][TOP] >UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HAF8_AJECH Length = 909 Score = 140 bits (353), Expect = 5e-32 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + ++ AK I S +KCDF I Sbjct: 318 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIF 377 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E + EKK+ +AE+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 378 EYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 433 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P PGH W ++ H+ TWLA W+++I Sbjct: 434 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENIN 492 Query: 517 G 519 G Sbjct: 493 G 493 [114][TOP] >UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR RepID=C0NC53_AJECG Length = 909 Score = 140 bits (353), Expect = 5e-32 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + ++ AK I S +KCDF I Sbjct: 318 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIF 377 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E + EKK+ +AE+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 378 EYYE----AARLEKKSLPSAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 433 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P PGH W ++ H+ TWLA W+++I Sbjct: 434 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-VPPPGHKWKEVKHDQEGTWLAMWQENIN 492 Query: 517 G 519 G Sbjct: 493 G 493 [115][TOP] >UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum RepID=Q9Y180_LEIIN Length = 635 Score = 140 bits (352), Expect = 7e-32 Identities = 83/177 (46%), Positives = 105/177 (59%), Gaps = 4/177 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---E 168 VAT +A + D+ E FR NFF +R +L K I LE CDF I + HL E Sbjct: 83 VATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQRE 140 Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348 + ++ K EKKA KE ++AEAE R + DGR E V NFRVEPP LF GRG Sbjct: 141 KKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGK 192 Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 HPL GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+DS+ G Sbjct: 193 HPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAG 248 [116][TOP] >UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani RepID=Q9NJG8_LEIDO Length = 949 Score = 140 bits (352), Expect = 7e-32 Identities = 83/177 (46%), Positives = 105/177 (59%), Gaps = 4/177 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---E 168 VAT +A + D+ E FR NFF +R +L K I LE CDF I + HL E Sbjct: 398 VATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQRE 455 Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348 + ++ K EKKA KE ++AEAE R + DGR E V NFRVEPP LF GRG Sbjct: 456 KKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGK 507 Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 HPL GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+DS+ G Sbjct: 508 HPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAG 563 [117][TOP] >UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN Length = 635 Score = 140 bits (352), Expect = 7e-32 Identities = 83/177 (46%), Positives = 105/177 (59%), Gaps = 4/177 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL---E 168 VAT +A + D+ E FR NFF +R +L K I LE CDF I + HL E Sbjct: 83 VATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQRE 140 Query: 169 DEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGD 348 + ++ K EKKA KE ++AEAE R + DGR E V NFRVEPP LF GRG Sbjct: 141 KKLSRTKEEKKAI-----KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGK 192 Query: 349 HPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 HPL GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+DS+ G Sbjct: 193 HPLMGKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDSVAG 248 [118][TOP] >UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei RepID=Q581U8_9TRYP Length = 661 Score = 140 bits (352), Expect = 7e-32 Identities = 75/173 (43%), Positives = 101/173 (58%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A + D+ E FR NFF +R +L K I LE CDFS I + E Sbjct: 111 VATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVE 168 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K+K+ +T E+KE + E + + +G++E V NFRVEPP LF GRG+HP+ Sbjct: 169 KRKS----RTREEKKELKRIADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMR 224 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+RI PEDV LN+G APIP+ P GH W ++H+ VTWLA W + G Sbjct: 225 GKLKKRILPEDVVLNIGKEAPIPQAPA-GHKWKGVVHDQNVTWLAMWYEPTIG 276 [119][TOP] >UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DTW1_TRYCR Length = 664 Score = 140 bits (352), Expect = 7e-32 Identities = 77/175 (44%), Positives = 106/175 (60%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A + D+ E FR NFF+ +R +L K I LE CDF I + HL + Sbjct: 86 VATMFAVMREHDYYRNEIFRRNFFSSWREIL--DKRQHPIRRLELCDFEPIYQWHLRER- 142 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 EKK T E K+ EAE+ + + + DG++E V NFRVEPP LF GRG HP Sbjct: 143 -----EKKLSRTKEEKKQLRLEAEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHP 197 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 + GK+K+R++PED+T+N+ +PIP+ P GH W +++H VTWLA W+DSI G Sbjct: 198 MMGKLKKRVEPEDITINIDEFSPIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILG 251 [120][TOP] >UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma brucei RepID=C9ZLY6_TRYBG Length = 696 Score = 140 bits (352), Expect = 7e-32 Identities = 75/173 (43%), Positives = 101/173 (58%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A + D+ E FR NFF +R +L K I LE CDFS I + E Sbjct: 146 VATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYEWHQREVE 203 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K+K+ +T E+KE + E + + +G++E V NFRVEPP LF GRG+HP+ Sbjct: 204 KRKS----RTREEKKELKRIADEEAEPYKWCIWNGKKEQVANFRVEPPGLFRGRGEHPMR 259 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+RI PEDV LN+G APIP+ P GH W ++H+ VTWLA W + G Sbjct: 260 GKLKKRILPEDVVLNIGKEAPIPQAPA-GHKWKGVVHDQNVTWLAMWYEPTIG 311 [121][TOP] >UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA Length = 580 Score = 140 bits (352), Expect = 7e-32 Identities = 68/172 (39%), Positives = 101/172 (58%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + +K ++I KC F + + E K Sbjct: 88 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEK 146 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 147 RKAATKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 202 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRIQ DV++N G + +P P PG W ++ H++ VTWLA W +++ G Sbjct: 203 MIKRRIQASDVSINCGKESKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 253 [122][TOP] >UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I, mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B7ZAR5_HUMAN Length = 503 Score = 140 bits (352), Expect = 7e-32 Identities = 71/164 (43%), Positives = 105/164 (64%), Gaps = 1/164 (0%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L ++ KE FR NFF+D+R +A + +VI SL+KCDF+ I + D+ A +K + Sbjct: 2 LDHEYTTKEVFRKNFFSDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59 Query: 205 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 381 E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP G +KRRI Sbjct: 60 ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115 Query: 382 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 PEDV +N ++ IPE P GH W ++ ++ VTWLA W +S+ Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 158 [123][TOP] >UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735 delta SOWgp RepID=C5P0Y8_COCP7 Length = 905 Score = 140 bits (352), Expect = 7e-32 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A++ T AK +I +KCDF I Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIF 373 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E K+ EKKA AERK + + + + DGR++ VGNFRVEPP LF Sbjct: 374 EYYE----MKREEKKALPAAERKRLKVEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 429 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 430 GRGEHPKTGRVKTRVQPEQITINIGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENIN 488 Query: 517 G 519 G Sbjct: 489 G 489 [124][TOP] >UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1D4R5_NEOFI Length = 886 Score = 140 bits (352), Expect = 7e-32 Identities = 78/181 (43%), Positives = 104/181 (57%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L T HV F+ NFF DF+ +L T AK I KCDF I Sbjct: 295 VAGFFGSMLNATQHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRPIF 354 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E K+ EKK AE+K + + + L DGR++ VGNFRVEPP LF Sbjct: 355 DYYE----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFR 410 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W+++I Sbjct: 411 GRGEHPKTGRVKARVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 469 Query: 517 G 519 G Sbjct: 470 G 470 [125][TOP] >UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata RepID=UPI000194D872 Length = 775 Score = 139 bits (351), Expect = 9e-32 Identities = 69/174 (39%), Positives = 106/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ + + Sbjct: 266 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF----- 319 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + E ER+ +++ ++D +E + NF++EPP LF GRG+HP Sbjct: 320 KAQSEARKQMSKEEKQKIKEENERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPK 379 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N ++ IP P PGH W ++ H++ VTWL W ++I G Sbjct: 380 MGMLKRRIMPEDIIINCSKDSKIP-APPPGHKWKEVRHDNKVTWLVSWTENIQG 432 [126][TOP] >UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra magnipapillata RepID=UPI000192545C Length = 726 Score = 139 bits (351), Expect = 9e-32 Identities = 72/174 (41%), Positives = 106/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L D+V K+ F NFF D+R + + +I SL+KCDF + A+ Sbjct: 205 VATFYAKMLDHDYVKKDIFNENFFEDWRKEMTAEE-RNIIKSLDKCDFKEMHAYF----- 258 Query: 181 KKKAEKKAQTTAERKEA-REAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K AE+K T E K+A +EA + ++ +DG ++ VGNFR+EPP LF GRGDHP Sbjct: 259 MKCAEEKRNMTKEEKQAIKEANLKIAEKYGFCEMDGHKQKVGNFRIEPPGLFRGRGDHPK 318 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+R+ ++V +N+G A +P+ P G W + H++ V+WLA W ++I G Sbjct: 319 QGKLKKRVSAKEVIINIGKEAKVPQ-PPEGQKWKAVQHDNTVSWLACWVENIAG 371 [127][TOP] >UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus caballus RepID=UPI0001797824 Length = 765 Score = 139 bits (351), Expect = 9e-32 Identities = 67/173 (38%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +ITSL KCDF+++ + KA Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF---KA 311 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 312 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 370 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422 [128][TOP] >UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta RepID=UPI00006D45A8 Length = 767 Score = 139 bits (351), Expect = 9e-32 Identities = 66/173 (38%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 313 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 314 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 372 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424 [129][TOP] >UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA Length = 560 Score = 139 bits (351), Expect = 9e-32 Identities = 66/173 (38%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 51 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 106 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 107 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 165 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 166 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 217 [130][TOP] >UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis RepID=Q1DXZ1_COCIM Length = 905 Score = 139 bits (351), Expect = 9e-32 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A++ T AK +I +KCDF I Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIF 373 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E K+ EKKA AERK + + + + DGR++ VGNFRVEPP LF Sbjct: 374 EYYE----MKREEKKALPAAERKRLKAEKEAAEAPYMYCMWDGRKQKVGNFRVEPPALFR 429 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 430 GRGEHPKTGRVKIRVQPEQITINIGKGAAVPP-PPAGHKWKEVKHDQEGTWLAMWQENIN 488 Query: 517 G 519 G Sbjct: 489 G 489 [131][TOP] >UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus scrofa RepID=UPI00017EFDA4 Length = 748 Score = 139 bits (350), Expect = 1e-31 Identities = 66/173 (38%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 240 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 295 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 296 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKM 354 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 355 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 406 [132][TOP] >UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B1DB6 Length = 770 Score = 139 bits (350), Expect = 1e-31 Identities = 71/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 261 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYF 314 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + E ER+ Q + ++D +E +GNFR+EPP LF GRGDHP Sbjct: 315 KAQSEARKQMSKEEKQKIKEENERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 374 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G Sbjct: 375 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 427 [133][TOP] >UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A48 Length = 632 Score = 139 bits (350), Expect = 1e-31 Identities = 73/173 (42%), Positives = 102/173 (58%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA F+A L ++ K+ FR NFF D+R + D + +I L KCDF I A KA Sbjct: 122 VALFFAQMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKA 177 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K +A K T E++ +EA + V +F L+D E +GNF++EPP LF GRG+HP Sbjct: 178 KVEARKN-MTKEEKQALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQ 236 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+RIQPED+ +N A IP P GH W ++ H++ VTWL W ++I G Sbjct: 237 GMLKKRIQPEDIIINCSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTENIQG 288 [134][TOP] >UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG Length = 783 Score = 139 bits (350), Expect = 1e-31 Identities = 71/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 242 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFTEM-----NEYF 295 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + E ER+ Q + ++D +E +GNFR+EPP LF GRGDHP Sbjct: 296 KAQSEARKQMSKEEKQKIKEENERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 355 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G Sbjct: 356 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 408 [135][TOP] >UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI Length = 1045 Score = 139 bits (350), Expect = 1e-31 Identities = 66/172 (38%), Positives = 101/172 (58%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + K ++I KC+F + E K Sbjct: 539 ATFYAKMLNHDYCTKDVFNNNFFKDFRKSMTP-KEKEIIKDFRKCNFQEMHQFFLAESEK 597 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + A++ E ++++ ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 598 RKAATKEEKLAKKNENEAL----IKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 653 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRI DV++N G + +P+ P PG W ++ H++ VTWLA W +++ G Sbjct: 654 MIKRRIAAADVSINCGKQSKVPQ-PPPGERWKEVRHDNTVTWLASWTENVQG 704 [136][TOP] >UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16 RepID=A8XXL4_CAEBR Length = 840 Score = 139 bits (350), Expect = 1e-31 Identities = 66/172 (38%), Positives = 110/172 (63%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA + ++ + +F +NF D+R L+ + K IT L KCDF+ H+ + + + Sbjct: 318 ATFYAGVVNHEYSSQVQFNTNFMKDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNE 372 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 ++ +KA T E+ + +E +A+ V + +A++DG +E + NFR+EPP +F GRG HP G Sbjct: 373 QREIRKAMTKEEKAKIKEEKAQEVVDYGIAIIDGHKEKIANFRIEPPGVFRGRGGHPKMG 432 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +K+RI PEDV +N G ++ IP+ P+ GH W ++ H++ V+WL W +S+ G Sbjct: 433 FIKKRIVPEDVIVNCGKDSVIPKPPL-GHKWKEVRHDNTVSWLCSWTESVLG 483 [137][TOP] >UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN Length = 765 Score = 139 bits (350), Expect = 1e-31 Identities = 66/173 (38%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 311 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 312 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 370 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422 [138][TOP] >UniRef100_B4DYD2 cDNA FLJ50294, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4DYD2_HUMAN Length = 503 Score = 139 bits (350), Expect = 1e-31 Identities = 72/164 (43%), Positives = 104/164 (63%), Gaps = 1/164 (0%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ A +K + Sbjct: 2 LDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59 Query: 205 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 381 E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP G +KRRI Sbjct: 60 ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115 Query: 382 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 PEDV +N ++ IPE P GH W ++ ++ VTWLA W +SI Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESI 158 [139][TOP] >UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN Length = 765 Score = 139 bits (350), Expect = 1e-31 Identities = 66/173 (38%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 311 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 312 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 370 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422 [140][TOP] >UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE Length = 767 Score = 139 bits (350), Expect = 1e-31 Identities = 66/173 (38%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 313 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 314 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKM 372 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424 [141][TOP] >UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus RepID=TOP1M_MOUSE Length = 593 Score = 139 bits (350), Expect = 1e-31 Identities = 72/172 (41%), Positives = 104/172 (60%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY L + KE FR NFF+D+R + + ++IT L+KCDF+ I H + Sbjct: 85 VATFYGKMLHLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE--- 140 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +AE + E+K+ + EAE+++Q F ++DG E +GNF+ EPP LF GRGDHP Sbjct: 141 --RAEARRTLPREQKQKLKEEAEKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPK 198 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRR+ PEDV +N ++ IPE P GH W ++ ++ V WLA W + I Sbjct: 199 MGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAWVEHI 249 [142][TOP] >UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155C8C4 Length = 781 Score = 139 bits (349), Expect = 2e-31 Identities = 66/173 (38%), Positives = 109/173 (63%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + + + IT+L KCDF+ + + KA Sbjct: 272 VATFFAKMLDHEYTTKDIFRKNFFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF---KA 327 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+++ +E + ++++ ++D E + NFR+EPP LF GRG+HP Sbjct: 328 QSEARKQ-MSKEEKQKIKEENEQLLKEYGFCVMDNHRERIANFRIEPPGLFRGRGNHPKM 386 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRIQPED+ +N ++ +P P PGH W ++ H++ VTWL W ++I G Sbjct: 387 GMLKRRIQPEDIIINCSKDSKVPP-PPPGHRWKEVRHDNKVTWLVSWTENIQG 438 [143][TOP] >UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI0001555600 Length = 689 Score = 139 bits (349), Expect = 2e-31 Identities = 70/172 (40%), Positives = 106/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +ATFY L ++ K+ F++NFF+D+R + + K I LE+CDF+ I + D+ Sbjct: 180 IATFYGKMLDHEYTTKDIFQNNFFSDWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNE 238 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +KA K E K+ + EAE++++ F ++DG E +GNF+ EPP LF GRGDHP Sbjct: 239 ARKALPK-----EEKQKLKEEAEKLQEEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPK 293 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI PEDV +N ++ IPE P GH W ++ ++ VTWLA W ++I Sbjct: 294 MGLLKKRIMPEDVIINCSKDSKIPE-PPSGHKWKEVRFDNTVTWLASWTENI 344 [144][TOP] >UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023DEFB Length = 910 Score = 139 bits (349), Expect = 2e-31 Identities = 78/184 (42%), Positives = 109/184 (59%), Gaps = 13/184 (7%) Frame = +1 Query: 1 VATFYASKLQT---DHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 153 VATF+ + + H+ FR NFF DF+ + D + KV I SL+KC+F +I Sbjct: 309 VATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFDKI 368 Query: 154 EAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEP 321 + +E K K +++ + +K+A EA FT DGR+E VGNFRVEP Sbjct: 369 NDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEAP------FTHCTWDGRKEKVGNFRVEP 422 Query: 322 PNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 501 P+LF GRG+HP TGKVK+R+QPE +T+N+G A IPE P GH W + H+ TWLA W Sbjct: 423 PSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMW 481 Query: 502 KDSI 513 +++I Sbjct: 482 QENI 485 [145][TOP] >UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR Length = 664 Score = 139 bits (349), Expect = 2e-31 Identities = 76/175 (43%), Positives = 106/175 (60%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEK 177 VAT +A + D+ E FR NFF+ +R +L + I LE CDF I + HL + Sbjct: 86 VATMFAVMREHDYYRNEIFRRNFFSSWREILDRRQHP--IRRLELCDFEPIYQWHLRER- 142 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 EKK T E K+ EAE+ + + + DG++E V NFRVEPP LF GRG HP Sbjct: 143 -----EKKLSRTKEEKKQLRLEAEKEAEPYKWCVWDGKKEQVANFRVEPPGLFRGRGQHP 197 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 + GK+K+R++PED+T+N+ +PIP+ P GH W +++H VTWLA W+DSI G Sbjct: 198 MMGKLKKRVEPEDITINIDEFSPIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILG 251 [146][TOP] >UniRef100_B7Z9E8 cDNA, FLJ78812, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B7Z9E8_HUMAN Length = 503 Score = 139 bits (349), Expect = 2e-31 Identities = 71/164 (43%), Positives = 104/164 (63%), Gaps = 1/164 (0%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + D+ A +K + Sbjct: 2 LDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSR- 59 Query: 205 QTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRI 381 E K+ + EAE+++Q F ++DG +E +GNF++EPP LF GRGDHP G +KRRI Sbjct: 60 ----EEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRI 115 Query: 382 QPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 PEDV +N ++ IPE P GH W ++ ++ VTWLA W +S+ Sbjct: 116 TPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVTWLAAWTESV 158 [147][TOP] >UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU Length = 909 Score = 139 bits (349), Expect = 2e-31 Identities = 78/184 (42%), Positives = 109/184 (59%), Gaps = 13/184 (7%) Frame = +1 Query: 1 VATFYASKLQT---DHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 153 VATF+ + + H+ FR NFF DF+ + D + KV I SL+KC+F +I Sbjct: 308 VATFWVAMMTAASIHHLENPVFRKNFFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKI 367 Query: 154 EAH----LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEP 321 + +E K K +++ + +K+A EA FT DGR+E VGNFRVEP Sbjct: 368 NDYWTKRVEQNKTKNMTKEEKEAAKAKKDALEAP------FTHCTWDGRKEKVGNFRVEP 421 Query: 322 PNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 501 P+LF GRG+HP TGKVK+R+QPE +T+N+G A IPE P GH W + H+ TWLA W Sbjct: 422 PSLFRGRGEHPKTGKVKQRVQPEQITINIGKGAKIPE-PPKGHQWKAVQHDQKATWLAMW 480 Query: 502 KDSI 513 +++I Sbjct: 481 QENI 484 [148][TOP] >UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC Length = 998 Score = 139 bits (349), Expect = 2e-31 Identities = 77/181 (42%), Positives = 104/181 (57%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L T HV F+ NFF DF+ +L T AK I KCDF I Sbjct: 407 VAGFFGSMLNATQHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDFRPIF 466 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + K+ EKK AE+K + + + L DGR++ VGNFRVEPP LF Sbjct: 467 DYYD----AKRIEKKNLPPAEKKRLKAEKDAAEAPYMYCLWDGRKQKVGNFRVEPPALFR 522 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G +AP+P P GH W ++ H+ TWLA W+++I Sbjct: 523 GRGEHPKTGRVKARVQPEQITINIGKDAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENIN 581 Query: 517 G 519 G Sbjct: 582 G 582 [149][TOP] >UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus RepID=UPI00006154BF Length = 769 Score = 138 bits (348), Expect = 2e-31 Identities = 66/173 (38%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 260 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 315 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 316 QTEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 374 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 375 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 426 [150][TOP] >UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK Length = 766 Score = 138 bits (348), Expect = 2e-31 Identities = 68/174 (39%), Positives = 105/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ + + Sbjct: 257 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHMSQYF----- 310 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K + E + Q + E K+ + E ER+ +++ ++D +E + NF++EPP LF GRG+HP Sbjct: 311 KAQTEARKQMSKEEKQKIKEENERLLKEYGYCVMDNHKERIANFKIEPPGLFRGRGNHPK 370 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N ++ +P P PGH W ++ H++ VTWL W ++I G Sbjct: 371 MGMLKRRIMPEDIIINCSKDSKVPP-PPPGHKWKEVRHDNKVTWLVSWTENIQG 423 [151][TOP] >UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major RepID=Q4Q2K0_LEIMA Length = 634 Score = 138 bits (348), Expect = 2e-31 Identities = 78/173 (45%), Positives = 101/173 (58%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A + D+ E FR NFF +R +L K I LE CDF I ++ Sbjct: 83 VATMFAVMKEHDYYRMEVFRRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQRE 140 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KK + K + A KE ++AEAE R + DGR E V NFRVEPP LF GRG HPL Sbjct: 141 KKLSRTKEEKKAI-KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLM 196 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K R+QPED+T+N+G A +P P GH W + H+ VTWLA W+D++ G Sbjct: 197 GKLKVRVQPEDITINIGETAEVP-VPPAGHKWAAVQHDHTVTWLAMWRDNVAG 248 [152][TOP] >UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE Length = 970 Score = 138 bits (348), Expect = 2e-31 Identities = 66/172 (38%), Positives = 101/172 (58%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ KE F +NFF DFR + + ++I KC F + + + E K Sbjct: 478 ATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCGFQEMFNYFQAESEK 536 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 537 RKAASKEEKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 592 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRI DV++N G ++ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 593 MIKRRIHASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 643 [153][TOP] >UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YQG7_NECH7 Length = 919 Score = 138 bits (348), Expect = 2e-31 Identities = 78/181 (43%), Positives = 109/181 (60%), Gaps = 10/181 (5%) Frame = +1 Query: 1 VATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRI 153 VATF+ + + + H+ FR NFF DF+ + D KV I SL+KCDF+++ Sbjct: 318 VATFWVAMMTPASSHHMENPVFRKNFFEDFQEYCKKYGVTDADGKKVQIKSLDKCDFTKL 377 Query: 154 EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNL 330 + AK + K T E KEA +A+ E + FT + DGR++ VGNFRVEPP+L Sbjct: 378 ADYW---LAKAEQNKTKNMTKEEKEAAKAKKEALEAPFTHCMWDGRKQKVGNFRVEPPSL 434 Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDS 510 F GRG+HP TGKVK R+ PE +T+N+G A IP+ P GH W + H+ TWLA W+++ Sbjct: 435 FRGRGEHPKTGKVKNRVTPEQITINIGKGAKIPD-PPKGHQWKAVQHDQKATWLAMWQEN 493 Query: 511 I 513 I Sbjct: 494 I 494 [154][TOP] >UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus norvegicus RepID=UPI0001B7BF13 Length = 760 Score = 138 bits (347), Expect = 3e-31 Identities = 66/173 (38%), Positives = 108/173 (62%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA Sbjct: 256 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 311 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D +E + NF++EPP LF GRG+HP Sbjct: 312 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHKERIANFKIEPPGLFRGRGNHPKM 370 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 371 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 422 [155][TOP] >UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE Length = 592 Score = 138 bits (347), Expect = 3e-31 Identities = 73/172 (42%), Positives = 105/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY L + KE FR NFF+D+R + + ++IT L+KCDF+ I H + Sbjct: 85 VATFYGKMLHLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHFLE--- 140 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +AE + E+K+ +E EAE+++Q F ++DG E +GNF+ EPP LF GRGDHP Sbjct: 141 --RAEARRTLPREQKQLKE-EAEKLQQEFGYCVLDGHREKIGNFKTEPPGLFRGRGDHPK 197 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRR+ PEDV +N ++ IPE P GH W ++ ++ V WLA W + I Sbjct: 198 MGMLKRRVMPEDVVINCSRDSKIPE-PPAGHQWKEVRSDNTVMWLAAWVEHI 248 [156][TOP] >UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis RepID=A4HB62_LEIBR Length = 637 Score = 138 bits (347), Expect = 3e-31 Identities = 75/173 (43%), Positives = 97/173 (56%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A + D+ E FR NFF +R +L K I LE CDF I E+ Sbjct: 83 VATMFAVMKEHDYYRMEAFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWYLAERE 140 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KK +T E+K +E + + + DGR E V NFRVEPP LF GRG HPL Sbjct: 141 KKLN----RTKEEKKSIKEKQDMDAEPYRYCMWDGRREQVANFRVEPPGLFRGRGKHPLM 196 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K R+QPE +T+N+G A +P P GH WG + H+ VTWLA W+DS+ G Sbjct: 197 GKLKARVQPEGITINIGETAEVP-VPPAGHKWGAVQHDHTVTWLAMWRDSVVG 248 [157][TOP] >UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2 Tax=Emericella nidulans RepID=C8VUK1_EMENI Length = 871 Score = 138 bits (347), Expect = 3e-31 Identities = 75/181 (41%), Positives = 105/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VA F+ S L T H F+ NFFADF+ +L T AK I KCDF I Sbjct: 280 VAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIF 339 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + ++ EKKA AE+K + + + + + DGR++ VGNFRVEPP+LF Sbjct: 340 QYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFR 395 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 396 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 454 Query: 517 G 519 G Sbjct: 455 G 455 [158][TOP] >UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA Length = 829 Score = 138 bits (347), Expect = 3e-31 Identities = 70/174 (40%), Positives = 105/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D++ + T +IT+L KCDF+ + + Sbjct: 312 VATFFAKMLDHEYTTKDIFRKNFFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF----- 365 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K+++E + T E K +AE ER+ Q + ++D +E + NFR+EPP LF GRGDHP Sbjct: 366 KEQSEARKNMTKEEKLKIKAENERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDHPK 425 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+RI PED+ +N ++ IP P GH W ++ H+ VTWL W ++I G Sbjct: 426 MGKLKKRIMPEDIIINCSKDSKIPVAPA-GHKWKEVRHDGKVTWLVSWTENIQG 478 [159][TOP] >UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0 Length = 758 Score = 137 bits (346), Expect = 3e-31 Identities = 66/173 (38%), Positives = 107/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA Sbjct: 249 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 304 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 305 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 363 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 364 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 415 [160][TOP] >UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT Length = 767 Score = 137 bits (346), Expect = 3e-31 Identities = 66/173 (38%), Positives = 107/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 313 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 314 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 372 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424 [161][TOP] >UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE Length = 767 Score = 137 bits (346), Expect = 3e-31 Identities = 66/173 (38%), Positives = 107/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + IT+L KCDF+++ + KA Sbjct: 258 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF---KA 313 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 314 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 372 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 373 GMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQG 424 [162][TOP] >UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5FAF Length = 573 Score = 137 bits (345), Expect = 4e-31 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 64 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYF 117 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDHP Sbjct: 118 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 177 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G Sbjct: 178 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 230 [163][TOP] >UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F97 Length = 790 Score = 137 bits (345), Expect = 4e-31 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 296 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYF 349 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDHP Sbjct: 350 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 409 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G Sbjct: 410 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 462 [164][TOP] >UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F96 Length = 767 Score = 137 bits (345), Expect = 4e-31 Identities = 70/174 (40%), Positives = 109/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E Sbjct: 258 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYF 311 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDHP Sbjct: 312 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 371 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G Sbjct: 372 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 424 [165][TOP] >UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CUT4_ASPTN Length = 872 Score = 137 bits (345), Expect = 4e-31 Identities = 76/181 (41%), Positives = 106/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIE 156 VA F+ S L T H F+ NFF DF+ +L D K KV I +KCDF I Sbjct: 281 VAGFFGSMLNSTQHTENPTFQKNFFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIF 340 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E K+ EK+ AE+K + + E+ + + DGR++ VGNFRVEPP+LF Sbjct: 341 DYYE----AKRIEKRNLPAAEKKRLKAEKDEQEAPYMYCMWDGRKQKVGNFRVEPPSLFR 396 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 397 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 455 Query: 517 G 519 G Sbjct: 456 G 456 [166][TOP] >UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6H1W4_PENCW Length = 864 Score = 137 bits (345), Expect = 4e-31 Identities = 73/181 (40%), Positives = 112/181 (61%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEK-FRSNFFADFRALLA------DTKFAKV-ITSLEKCDFSRIE 156 VA+F+ + L + H ++ F+ NFF+DF+ ++ D+K KV I KCDF I Sbjct: 272 VASFFGTMLNSTHNVENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIF 331 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + ++ EK+ AE+K A+ + E+ + + DGR++ VGNFRVEPP+LF Sbjct: 332 EFYDAQRE----EKRHLPPAEKKAAKALKDEQEAPYQYCIWDGRKQKVGNFRVEPPSLFR 387 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G +A +P P PGH W ++ H+ TWLA W+++I Sbjct: 388 GRGEHPKTGRVKTRVQPEQITINIGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENIN 446 Query: 517 G 519 G Sbjct: 447 G 447 [167][TOP] >UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI Length = 871 Score = 137 bits (344), Expect = 6e-31 Identities = 75/181 (41%), Positives = 104/181 (57%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VA F+ S L T H F+ NFFADF+ +L T AK I KCDF I Sbjct: 280 VAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIF 339 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + ++ EKKA AE+K + + + + + DGR++ VGNFRVEPP LF Sbjct: 340 QYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPPLFR 395 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 396 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 454 Query: 517 G 519 G Sbjct: 455 G 455 [168][TOP] >UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio RepID=UPI000176075D Length = 531 Score = 136 bits (343), Expect = 8e-31 Identities = 69/174 (39%), Positives = 105/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEK 177 VA ++A L ++ KE FR+NFF D+R + + ++I L+KCDF + A H E + Sbjct: 22 VALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVE 80 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 A+K K+ E+ +EA + V ++ ++D E +GNF++EPP LF GRGDHP Sbjct: 81 ARKNLSKE-----EKLVNKEANQKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPK 135 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+RI+PEDV +N + IPE P GH W ++ H+ VTWLA W +++ G Sbjct: 136 QGMLKKRIRPEDVIINCSKESRIPEAPA-GHKWKEVRHDKTVTWLASWTENVQG 188 [169][TOP] >UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica RepID=UPI0000F2B3E5 Length = 916 Score = 136 bits (343), Expect = 8e-31 Identities = 68/174 (39%), Positives = 106/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + + IT+L KCDF++I + Sbjct: 407 VATFFAKMLDHEYTTKDIFRKNFFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF----- 460 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K + E ER+ +++ ++D E + NF++EPP LF GRG+HP Sbjct: 461 KAQSEARKQMSKEEKLKIKEENERLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPK 520 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P PGH W ++ H++ VTWL W ++I G Sbjct: 521 MGMLKRRIMPEDIIINCSKDAKVPP-PPPGHKWKEVRHDNKVTWLVSWTENIQG 573 [170][TOP] >UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio RepID=UPI0001A2C88D Length = 609 Score = 136 bits (343), Expect = 8e-31 Identities = 69/174 (39%), Positives = 105/174 (60%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEK 177 VA ++A L ++ KE FR+NFF D+R + + ++I L+KCDF + A H E + Sbjct: 100 VALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVE 158 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 A+K K+ E+ +EA + V ++ ++D E +GNF++EPP LF GRGDHP Sbjct: 159 ARKNLSKE-----EKLVNKEANQKIVDEYGFCVLDHHRERIGNFKIEPPGLFRGRGDHPK 213 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+RI+PEDV +N + IPE P GH W ++ H+ VTWLA W +++ G Sbjct: 214 QGMLKKRIRPEDVIINCSKESRIPEAPA-GHKWKEVRHDKTVTWLASWTENVQG 266 [171][TOP] >UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU Length = 767 Score = 136 bits (343), Expect = 8e-31 Identities = 69/174 (39%), Positives = 108/174 (62%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + + Sbjct: 258 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGMNDYF----- 311 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 K ++E + Q + E K+ + + ER+ Q + ++D +E +GNFR+EPP LF GRGDHP Sbjct: 312 KAQSEARKQMSKEEKQKIKEDNERILQEYGFCIMDNHKERIGNFRIEPPGLFRGRGDHPK 371 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA W ++I G Sbjct: 372 MGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLASWTENIQG 424 [172][TOP] >UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus (Silurana) tropicalis RepID=Q0V9D3_XENTR Length = 495 Score = 136 bits (343), Expect = 8e-31 Identities = 66/173 (38%), Positives = 107/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA+F+A L ++ KE FR+N+F D+R + + VIT L KCDF+ + + + Sbjct: 172 VASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG--- 227 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K EKK ++ ++ + +E + ++++ +D E +GNF++EPP LF GRGDHP Sbjct: 228 -KMEEKKNKSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQ 286 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +K+RI PED+ +N ++ IPE P PGH W ++ H++ VTWLA W +++ G Sbjct: 287 GMLKKRILPEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQG 338 [173][TOP] >UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA Length = 969 Score = 136 bits (343), Expect = 8e-31 Identities = 68/174 (39%), Positives = 107/174 (61%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA L+ D+ K+ F NFF D+R + + + IT LEKC+F + A+ + Sbjct: 481 VAGFYARMLEHDYTSKQAFNDNFFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEI-- 537 Query: 181 KKKAEKKAQTTAERKEAREAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 AE+ + E K A +A E++ +++ + ++DG +E +GNF++EPP LF GRG+HP Sbjct: 538 ---AEQNRNRSKEEKAALKAANEQLTKEYGICVIDGHKEKIGNFKIEPPGLFRGRGEHPK 594 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G VKRR+ PEDV +N ++ IP P PG W ++ H++ V+WLA W +++ G Sbjct: 595 MGLVKRRVMPEDVIINCSQDSKIPS-PPPGRRWKEVRHDNTVSWLASWVENVQG 647 [174][TOP] >UniRef100_A7SLG4 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SLG4_NEMVE Length = 502 Score = 136 bits (343), Expect = 8e-31 Identities = 66/165 (40%), Positives = 102/165 (61%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L+ D+ KE F NFF+D+R + + + K I L+ CDF + + E K E+K Sbjct: 2 LEHDYTSKEIFNKNFFSDWRKEMTEEE-RKHIKDLKNCDFKEMHKYFE----MKNEERKN 56 Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384 T E+ E ++ E + ++ ++D ++ VGNF++EPP LF GRGDHP GK+K+R+ Sbjct: 57 MTKEEKLEIKKKNEEILNEYGFCMMDHHKQRVGNFKIEPPGLFRGRGDHPKQGKLKKRVM 116 Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 PE+VT+N+G +A +P+ P GH W K+I + VTWLA W ++I G Sbjct: 117 PEEVTINIGKDAKVPD-PPAGHKWKKVICDDTVTWLACWIENIQG 160 [175][TOP] >UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis RepID=C5GB81_AJEDR Length = 911 Score = 136 bits (343), Expect = 8e-31 Identities = 75/181 (41%), Positives = 103/181 (56%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + + AK I S + CDF I Sbjct: 320 VAGFFGSMLNSTHNVENPTFQKNFFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKPIF 379 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + E + EKK AE+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 380 EYYE----AARLEKKNLPAAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 435 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G +A +P P PGH W ++ H+ TWLA W+++I Sbjct: 436 GRGEHPKTGKVKTRVMPEQITINIGKDAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENIN 494 Query: 517 G 519 G Sbjct: 495 G 495 [176][TOP] >UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina RepID=B2AY06_PODAN Length = 904 Score = 136 bits (343), Expect = 8e-31 Identities = 76/181 (41%), Positives = 105/181 (58%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VATF+ + L T +V F+ NFF DFR +L +T AK I K DF++I Sbjct: 309 VATFFGAMLHSTQNVENPTFQKNFFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIF 368 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + KKA A+ AE+ E + EA + DGR+E VGNFRVEPP LF Sbjct: 369 EYYKGLSEAKKARPAAEKKAEKAEKDKFEAP----YMYCKWDGRKEKVGNFRVEPPGLFR 424 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG VK+R+ PE VT+N+G A +P+ P GH W + H++ TWLA W++++ Sbjct: 425 GRGEHPKTGTVKKRVMPEQVTINIGKEAKVPD-PPAGHKWKAVQHDNKATWLAMWQENVN 483 Query: 517 G 519 G Sbjct: 484 G 484 [177][TOP] >UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax adhaerens RepID=B3S6N7_TRIAD Length = 560 Score = 136 bits (342), Expect = 1e-30 Identities = 72/175 (41%), Positives = 105/175 (60%), Gaps = 3/175 (1%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEK 177 A FYA L D+ K+ F NF+ DFR + A+ KV + KCDFS+I E Sbjct: 52 AGFYAKMLDHDYTQKKIFNDNFWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EY 103 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 K KAE++ + E K + E E + Q + ++DG + VGNF++EPP LF GRGDHP Sbjct: 104 YKMKAEERRNMSKEEKNKLKKENEELMQEYGFCIIDGHRQRVGNFKIEPPGLFRGRGDHP 163 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+KRRI+ +D+ +N+G +A +P P PG W ++ +++ VTWLA W ++I G Sbjct: 164 KQGKIKRRIEAKDIIINIGKDAKLP-APPPGQKWKEVRYDNKVTWLASWTENING 217 [178][TOP] >UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI00005A45B7 Length = 1004 Score = 135 bits (341), Expect = 1e-30 Identities = 65/173 (37%), Positives = 107/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 495 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 550 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 551 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 609 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P GH W ++ H++ VTWL W ++I G Sbjct: 610 GMLKRRIMPEDIIINCSKDAKVPS-PPTGHKWKEVRHDNKVTWLVSWTENIQG 661 [179][TOP] >UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30 Length = 752 Score = 135 bits (341), Expect = 1e-30 Identities = 65/173 (37%), Positives = 107/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + KA Sbjct: 243 VATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF---KA 298 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A K+ + E+ + +E + ++++ ++D E + NF++EPP LF GRG+HP Sbjct: 299 QSEARKQ-MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKM 357 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI PED+ +N +A +P P GH W ++ H++ VTWL W ++I G Sbjct: 358 GMLKRRIMPEDIIINCSKDAKVPS-PPTGHKWKEVRHDNKVTWLVSWTENIQG 409 [180][TOP] >UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE Length = 469 Score = 135 bits (341), Expect = 1e-30 Identities = 68/173 (39%), Positives = 106/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF++ L ++ K+ FR NFF D+R + + +K IT L KCDFS + + KA Sbjct: 249 VATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KA 304 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A +KA T E+ + +E ++++ ++D +E + NFR+EPP LF GRGDHP Sbjct: 305 QSEA-RKAMTKEEKLKIKEENERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 363 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P P PG W ++ H++ VTWL W ++I G Sbjct: 364 GMLKRRIRPEDIIINCSKDSKHP-TPPPGTKWKEVRHDNKVTWLVSWTENIQG 415 [181][TOP] >UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE Length = 758 Score = 135 bits (341), Expect = 1e-30 Identities = 68/173 (39%), Positives = 106/173 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF++ L ++ K+ FR NFF D+R + + +K IT L KCDFS + + KA Sbjct: 249 VATFFSKMLDHEYTTKDIFRKNFFKDWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KA 304 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + +A +KA T E+ + +E ++++ ++D +E + NFR+EPP LF GRGDHP Sbjct: 305 QSEA-RKAMTKEEKLKIKEENERILQEYGFCIMDNHKERIANFRIEPPGLFRGRGDHPKM 363 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G +KRRI+PED+ +N ++ P P PG W ++ H++ VTWL W ++I G Sbjct: 364 GMLKRRIRPEDIIINCSKDSKHP-TPPPGTKWKEVRHDNKVTWLVSWTENIQG 415 [182][TOP] >UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR Length = 1063 Score = 135 bits (341), Expect = 1e-30 Identities = 65/172 (37%), Positives = 101/172 (58%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L D+ K+ F +NFF DFR + K ++I KC+F + + E K Sbjct: 557 ATFYAKMLNHDYCTKDVFNTNFFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEK 615 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 +KA K + ++ E V+++ ++DG +E +GNFR+EPP LF GRG+HP G Sbjct: 616 RKAATKEEKLLKKNENEAL----VKEYGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMG 671 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRRI DV++N G + +P+ P+ G W ++ H++ VTWLA W +++ G Sbjct: 672 MIKRRIAAADVSINCGKQSKVPQPPM-GGRWKEVRHDNTVTWLASWTENVQG 722 [183][TOP] >UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus RepID=B0WA62_CULQU Length = 962 Score = 135 bits (340), Expect = 2e-30 Identities = 67/173 (38%), Positives = 104/173 (60%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA ++ ++ K+ F NFF D+R + ++ K I L+KC+F + A+ D Sbjct: 458 VAGFYARMIEHEYTSKDVFNDNFFKDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSE 516 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K + K + A KE EA V+++ + +DG +E +GNFR+EPP LF GRG+HP Sbjct: 517 KNRNRSKEEKLA-LKEQNEA---LVKEYGICNIDGHKEKIGNFRIEPPGLFRGRGEHPKM 572 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G VKRR+ PEDV +N ++ P+ P GH W ++ H++ V+WLA W +++ G Sbjct: 573 GLVKRRVMPEDVIINCAKDSVYPKAP-EGHRWKEVRHDNTVSWLASWTENVQG 624 [184][TOP] >UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01 RepID=C1H484_PARBA Length = 900 Score = 135 bits (340), Expect = 2e-30 Identities = 76/181 (41%), Positives = 102/181 (56%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + + AK I S +KCDF I Sbjct: 309 VAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKPIF 368 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 E + EKKA AE+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 369 EFYE----AARLEKKALPAAEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 424 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 425 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-TPPAGHKWKEVKHDQEGTWLAMWQENIN 483 Query: 517 G 519 G Sbjct: 484 G 484 [185][TOP] >UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia guttata RepID=UPI000194BDF0 Length = 662 Score = 135 bits (339), Expect = 2e-30 Identities = 66/172 (38%), Positives = 105/172 (61%), Gaps = 1/172 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + ++ Sbjct: 153 IATFYAKMLNHEYTTKEIFQNNFFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEKNE 211 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +K K E K+ + EA+++++ + ++DG E +GNF+ EPP LF GRG+HP Sbjct: 212 ARKGLPK-----EEKQKLKEEADKIQEEYGYCILDGHREKIGNFKTEPPGLFRGRGEHPK 266 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI PEDV +N ++ IPE P GH W ++ ++ VTWLA W ++I Sbjct: 267 MGMLKKRIMPEDVIINCSKDSKIPE-PPEGHKWKEVRFDNTVTWLASWTENI 317 [186][TOP] >UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG Length = 806 Score = 135 bits (339), Expect = 2e-30 Identities = 74/192 (38%), Positives = 108/192 (56%), Gaps = 19/192 (9%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATF+A L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + + + Sbjct: 224 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTE 282 Query: 181 KKKAEKKAQTTAE------RKEAREA------------EAERV-RQFTVALVDGREETVG 303 +KA K + R+ R A E ER+ +QF ++D +E + Sbjct: 283 ARKAMTKEEKLVSPHPHSCRRRLRAAGFIPSAFQKIKEENERILQQFGFCIMDNHKERIA 342 Query: 304 NFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCV 483 NFR+EPP LF GRGDHP G +KRRI+PED+ +N ++ PE P PG W ++ H++ V Sbjct: 343 NFRIEPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKYPE-PPPGTRWKEVRHDNKV 401 Query: 484 TWLAGWKDSITG 519 TWL W ++I G Sbjct: 402 TWLVSWTENIQG 413 [187][TOP] >UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI Length = 871 Score = 135 bits (339), Expect = 2e-30 Identities = 74/181 (40%), Positives = 104/181 (57%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VA F+ S L T H F+ NFFADF+ +L T AK I KCD I Sbjct: 280 VAGFFGSMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIF 339 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + ++ EKKA AE+K + + + + + DGR++ VGNFRVEPP+LF Sbjct: 340 QYYDAQRQ----EKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPSLFR 395 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG+VK R+QPE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 396 GRGEHPKTGRVKARVQPEQITINIGKEARVPP-PPEGHKWKEVKHDQEGTWLAMWQENIN 454 Query: 517 G 519 G Sbjct: 455 G 455 [188][TOP] >UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294 Length = 786 Score = 134 bits (338), Expect = 3e-30 Identities = 69/175 (39%), Positives = 105/175 (60%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRA-LLADTKFAKVITSLEKCDFSRIEAHLEDEK 177 VATF+A L ++ K+ FR NFF D++ + AD + +IT+L KCDF+ + + Sbjct: 275 VATFFAKMLDHEYTTKDIFRKNFFKDWKKEMTADER--NLITNLGKCDFNAMSQYF---- 328 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQ-FTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 K+++E + T E K+ + E ER+ Q + ++D E + NFR+EPP LF GRGDHP Sbjct: 329 -KEQSEARKNMTKEEKQKIKEENERLLQEYGFCVMDNHRERIANFRIEPPGLFRGRGDHP 387 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+RI PED+ +N ++ P P GH W ++ H+ VTWL W ++I G Sbjct: 388 KMGKLKKRIMPEDIIINCSKDSKYPVAPA-GHKWKEVRHDGKVTWLVSWTENIQG 441 [189][TOP] >UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7EXF7_SCLS1 Length = 911 Score = 134 bits (338), Expect = 3e-30 Identities = 74/181 (40%), Positives = 102/181 (56%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 +A F+ + L + H V F+ NFF DF + T AK I K DF I Sbjct: 316 IAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIF 375 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + K E+KA++ AE+K + A+ E + + DGR+E VGNFRVEPP LF Sbjct: 376 EYYDG----KSTERKARSAAEKKAEKAAKDEAEAPYKTCIWDGRKEDVGNFRVEPPGLFR 431 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P GH W I H++ TWLA W+++I Sbjct: 432 GRGEHPKTGKVKLRVTPEQITINIGKEATVPS-PPEGHKWKAIQHDNKATWLAMWQENIN 490 Query: 517 G 519 G Sbjct: 491 G 491 [190][TOP] >UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R0K7_MAGGR Length = 906 Score = 134 bits (337), Expect = 4e-30 Identities = 79/181 (43%), Positives = 101/181 (55%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIE 156 VATF+ S L T +V F NFF F+ L T AK I EK DF I Sbjct: 310 VATFFGSMLHSTQNVENPTFIKNFFTGFKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIF 369 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 H + + KKA K + AE KEAR+ E + DGR+E VGNFRVEPP LF Sbjct: 370 QHFQAQSEAKKARSKEEKKAE-KEARDKMEE---PYKYCKWDGRKEKVGNFRVEPPALFR 425 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TG +K R+ PE VT+N+G A +PE P GH W + H++ TWLA W++++ Sbjct: 426 GRGEHPKTGTIKERVPPEAVTINIGKGAKVPE-PPAGHKWKAVQHDNKATWLAMWQENVN 484 Query: 517 G 519 G Sbjct: 485 G 485 [191][TOP] >UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B3173 Length = 622 Score = 134 bits (336), Expect = 5e-30 Identities = 71/177 (40%), Positives = 104/177 (58%), Gaps = 4/177 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I A KA Sbjct: 106 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAM---HKA 161 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K +A K + E+ +EA + + ++ L+D E +GNF++EPP LF GRG+HP Sbjct: 162 KVEARKN-MSKEEKLVLKEANQKILDEYGYCLLDHHRERIGNFKIEPPGLFRGRGEHPKQ 220 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVP----GHNWGKIIHNSCVTWLAGWKDSITG 519 GK+K+RIQPEDV +N + E +P GH W ++ H++ VTWLA W ++I G Sbjct: 221 GKLKKRIQPEDVIINCSNSRVDRESRIPVPPAGHRWKEVRHDNTVTWLASWTENIQG 277 [192][TOP] >UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18 RepID=C1GKM6_PARBD Length = 825 Score = 134 bits (336), Expect = 5e-30 Identities = 75/181 (41%), Positives = 101/181 (55%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + + AK I S +KCDF I Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIF 373 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 E + EKKA E+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 374 EFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 429 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 430 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENIN 488 Query: 517 G 519 G Sbjct: 489 G 489 [193][TOP] >UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03 RepID=C0SEQ3_PARBP Length = 905 Score = 134 bits (336), Expect = 5e-30 Identities = 75/181 (41%), Positives = 101/181 (55%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 VA F+ S L + H V F+ NFF DF A + + AK I S +KCDF I Sbjct: 314 VAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKPIF 373 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 E + EKKA E+K + + E + + DGR++ VGNFRVEPP LF Sbjct: 374 EFYE----AARLEKKALPATEKKRLKAEKDELEAPYMYCMWDGRKQKVGNFRVEPPALFR 429 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G A +P P GH W ++ H+ TWLA W+++I Sbjct: 430 GRGEHPKTGKVKTRVMPEQITINIGKEAKVP-IPPAGHKWKEVKHDQEGTWLAMWQENIN 488 Query: 517 G 519 G Sbjct: 489 G 489 [194][TOP] >UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A49 Length = 692 Score = 133 bits (335), Expect = 6e-30 Identities = 70/180 (38%), Positives = 101/180 (56%), Gaps = 7/180 (3%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEK 177 VA F+A L ++ K+ FR NFF D+R + D + +I L KCDF I A H + Sbjct: 121 VALFFAQMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAMHKAKVE 179 Query: 178 AKKKAEKKAQTTAE------RKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 339 A+K K+ + + +EA + V +F L+D E +GNF++EPP LF G Sbjct: 180 ARKNMTKEEKQVCNIHFIMLKNALKEANQKIVDEFGYCLLDHHRERIGNFKIEPPGLFRG 239 Query: 340 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 RG+HP G +K+RIQPED+ +N A IP P GH W ++ H++ VTWL W ++I G Sbjct: 240 RGEHPKQGMLKKRIQPEDIIINCSKEACIP-VPPAGHRWKEVRHDNTVTWLVSWTENIQG 298 [195][TOP] >UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana B05.10 RepID=A6S3Q9_BOTFB Length = 912 Score = 133 bits (335), Expect = 6e-30 Identities = 74/181 (40%), Positives = 102/181 (56%), Gaps = 8/181 (4%) Frame = +1 Query: 1 VATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIE 156 +A F+ + L + H V F+ NFF DF + T AK I K DF I Sbjct: 317 IAGFFGAMLNSTHNVENPTFQKNFFKDFTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIF 376 Query: 157 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFL 336 + + + ++KA A+ AE+ EAEA + + DGR+E VGNFRVEPP LF Sbjct: 377 EYYDGKSTERKARSAAEKKAEKALKDEAEAP----YKTCIWDGRKEDVGNFRVEPPGLFR 432 Query: 337 GRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 GRG+HP TGKVK R+ PE +T+N+G +A +P P GH W I H++ TWLA W+++I Sbjct: 433 GRGEHPKTGKVKLRVTPEQITINIGKDATVPS-PPEGHKWKAIQHDNKATWLAMWQENIN 491 Query: 517 G 519 G Sbjct: 492 G 492 [196][TOP] >UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE Length = 966 Score = 132 bits (333), Expect = 1e-29 Identities = 66/173 (38%), Positives = 101/173 (58%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A FYA L+ ++ K+ F NFF D+R + ++ K I L+KC+F + H + Sbjct: 463 IAGFYARMLEHEYTSKDAFNDNFFKDWRKSMTSSEREK-IKDLKKCNFRSMHKHFAEISE 521 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 + K Q A KE EA ++++ +DG +E +GNFR+EPP LF GRG+HP Sbjct: 522 ANRNRTKEQKLA-LKEQNEA---LMKEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHPKM 577 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G VKRR+ PEDV +N G + P+ P GH W ++ H++ V+WLA W +++ G Sbjct: 578 GMVKRRVMPEDVIINCGKESVWPKAP-EGHRWKEVRHDNSVSWLASWTENVQG 629 [197][TOP] >UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66 RepID=B6ABX7_9CRYT Length = 660 Score = 132 bits (333), Expect = 1e-29 Identities = 71/173 (41%), Positives = 105/173 (60%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +AT++A L T+ KE+F N F + + + +KCDFS I+ H ++EK Sbjct: 90 IATYWAQILDTEWSSKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEEKE 149 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +KK K Q +++ E+E+ + ALVD +E VGNFR+EPP LF GRG+HP + Sbjct: 150 RKKNMNKEQKEQQKRIKNESESP----YIYALVDWIKEKVGNFRIEPPGLFRGRGEHPKS 205 Query: 361 GKVKRRIQPEDVTLNLGPNAPIP--ECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI E+VTLN+ +AP+P + + GH W + H+S VTWLA +KDSI Sbjct: 206 GMLKKRIFSEEVTLNVAEDAPVPKVDSSIIGHAWKDVFHDSNVTWLAYYKDSI 258 [198][TOP] >UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SIQ6_9PEZI Length = 891 Score = 132 bits (333), Expect = 1e-29 Identities = 69/176 (39%), Positives = 109/176 (61%), Gaps = 4/176 (2%) Frame = +1 Query: 4 ATFYASKLQT-DHVLKEKFRSNFFADFRALLADTKFA--KVITSLEKCDFSRIEAH-LED 171 A F+ S + ++V F+ NFF DFR ++ + A K ++ DF +I + D Sbjct: 298 AWFFGSMFHSKNNVDNPTFQKNFFEDFREVIKEHGSATDKDGKKVDIKDFHKINWQPMAD 357 Query: 172 EKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 ++ A +K +T E+K+ +E + R F L DGR+E +GNFRVEPP+LF GRGDH Sbjct: 358 YAEQQSAMRKNRTKEEKKQIKEEKDAREEPFKYCLWDGRKEKMGNFRVEPPSLFRGRGDH 417 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 P TG++K+++ PE +T+N+G +A IP+ P GH W ++H++ TWLA W+++I G Sbjct: 418 PKTGRIKKQVFPEQITINIGKDAKIPK-PPDGHKWKAVVHDNKATWLASWQENING 472 [199][TOP] >UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni RepID=C4Q6C8_SCHMA Length = 587 Score = 132 bits (332), Expect = 1e-29 Identities = 65/171 (38%), Positives = 101/171 (59%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA L D+ KE F NFF D+ + + + + I SL KCDF + + Sbjct: 177 VAGFYARMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----L 231 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K E+K +T E+++ +E + ++ ++DG ++ +GNFR+EPP LF GRG+HP Sbjct: 232 KLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKM 291 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI PEDV +N ++ +P P GH W ++ H++ VTWLA W ++I Sbjct: 292 GMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACWTENI 341 [200][TOP] >UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni RepID=C4Q6C7_SCHMA Length = 652 Score = 132 bits (332), Expect = 1e-29 Identities = 65/171 (38%), Positives = 101/171 (59%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA L D+ KE F NFF D+ + + + + I SL KCDF + + Sbjct: 177 VAGFYARMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----L 231 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K E+K +T E+++ +E + ++ ++DG ++ +GNFR+EPP LF GRG+HP Sbjct: 232 KLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKM 291 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K+RI PEDV +N ++ +P P GH W ++ H++ VTWLA W ++I Sbjct: 292 GMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACWTENI 341 [201][TOP] >UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA Length = 1019 Score = 132 bits (331), Expect = 2e-29 Identities = 71/175 (40%), Positives = 94/175 (53%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174 +A FYA KL+T H F NFF DF+ L + I S +K DF + + Sbjct: 202 IAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSL 261 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 K + KKA + RK E ++ + LVDG E+ VGN VEPP LFLGRG HP Sbjct: 262 KDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHP 321 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 GKVKRRI P D+T+N + P P+ P +W +++ VTWLA WK++I G Sbjct: 322 KAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENING 376 [202][TOP] >UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F98 Length = 790 Score = 131 bits (330), Expect = 2e-29 Identities = 69/188 (36%), Positives = 109/188 (57%), Gaps = 15/188 (7%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 168 VATF+A L ++ K+ FR NFF D+R + + +K IT L KC+F+ + +A E Sbjct: 231 VATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGMNEYFKAQSE 289 Query: 169 DEKAKKKAEKKA-----------QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRV 315 K K EK+ +T++ + +E ++++ ++D +E +GNFR+ Sbjct: 290 ARKQMSKEEKQVSLHSITCSPALKTSSHLNKIKEDNERILQEYGFCIMDNHKERIGNFRI 349 Query: 316 EPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLA 495 EPP LF GRGDHP G +KRRI+PED+ +N ++ P+ P PG W ++ H++ VTWLA Sbjct: 350 EPPGLFRGRGDHPKMGMLKRRIRPEDIIINCSKDSKHPK-PPPGTKWKEVRHDNKVTWLA 408 Query: 496 GWKDSITG 519 W ++I G Sbjct: 409 SWTENIQG 416 [203][TOP] >UniRef100_Q1WWG8 IP16129p (Fragment) n=1 Tax=Drosophila melanogaster RepID=Q1WWG8_DROME Length = 382 Score = 131 bits (330), Expect = 2e-29 Identities = 62/165 (37%), Positives = 98/165 (59%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L D+ KE F +NFF DFR + + ++I KC+F + + + E K+KA K Sbjct: 2 LNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFRKCNFQEMFNYFQAESEKRKAASKE 60 Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384 + ++ E +++F ++DG +E +GNFR+EPP LF GRG+HP G +KRRIQ Sbjct: 61 EKLIKKNENEAL----MKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQ 116 Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 DV++N G ++ +P P PG W ++ H++ VTWLA W +++ G Sbjct: 117 ASDVSINCGKDSKVPS-PPPGSRWKEVRHDNTVTWLASWIENVQG 160 [204][TOP] >UniRef100_Q4V7M4 MGC115546 protein n=1 Tax=Xenopus laevis RepID=Q4V7M4_XENLA Length = 503 Score = 131 bits (329), Expect = 3e-29 Identities = 63/165 (38%), Positives = 101/165 (61%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L ++ KE FR+NFF D+R + + VIT L+KCDF+ + + + K EKK Sbjct: 2 LDHEYTTKEIFRNNFFVDWRKEMT-LEEKMVITDLDKCDFTEMFTYYKG----KMEEKKN 56 Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384 ++ ++ + +E + + ++ +D E +GNF++EPP LF GRGDHP G +K+RI Sbjct: 57 KSKEDKLKIKEENEKLLEEYGYCAMDHHREKIGNFKIEPPALFRGRGDHPKQGMLKKRIL 116 Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 PED+ +N ++ IPE P PGH W ++ H++ VTWLA W +++ G Sbjct: 117 PEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQG 160 [205][TOP] >UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium parvum Iowa II RepID=Q5CY81_CRYPV Length = 653 Score = 130 bits (328), Expect = 4e-29 Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A++++ T+ KEKF +N F + EKC+F I+ + EDEK Sbjct: 94 IASYWSVMKDTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKE 153 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KK K + ++K + E+ F ALVD +E VGNFR+EPP LF GRG+HP + Sbjct: 154 AKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNFRIEPPGLFKGRGEHPKS 209 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDVTLN+ +AP+P+ P + GH W I H++ VTWLA ++DSI Sbjct: 210 GMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRDSI 262 [206][TOP] >UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis RepID=Q5CN58_CRYHO Length = 641 Score = 130 bits (328), Expect = 4e-29 Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 2/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +A++++ T+ KEKF +N F + EKC+F I+ + EDEK Sbjct: 82 IASYWSVMKDTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKE 141 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KK K + ++K + E+ F ALVD +E VGNFR+EPP LF GRG+HP + Sbjct: 142 AKKNLSKEEKELQKKCRGDQESP----FVYALVDWIKEKVGNFRIEPPGLFKGRGEHPKS 197 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECP--VPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDVTLN+ +AP+P+ P + GH W I H++ VTWLA ++DSI Sbjct: 198 GMLKRRIFPEDVTLNIAEDAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRDSI 250 [207][TOP] >UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum RepID=Q5C1T3_SCHJA Length = 330 Score = 130 bits (327), Expect = 5e-29 Identities = 64/167 (38%), Positives = 98/167 (58%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA L D+ KE F NFF D+ + + + + I SL KCDF + + Sbjct: 169 VAGFYARMLDHDYTTKEVFNHNFFHDWVKTMNEEE-RRTIKSLSKCDFQEMHQYF----L 223 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K E+K +T E+++ +E + ++ ++DG ++ +GNFR+EPP LF GRG+HP Sbjct: 224 KLSEERKNRTKEEKQKIKEENLQIQNEYGYCILDGHKQRIGNFRIEPPGLFRGRGNHPKM 283 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGW 501 G +K+RI PEDV +N ++ +P P GH W ++ H++ VTWLA W Sbjct: 284 GMLKKRIMPEDVIINCSKDSKVP-APPKGHKWKEVRHDNSVTWLACW 329 [208][TOP] >UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PY85_MALGO Length = 877 Score = 130 bits (326), Expect = 7e-29 Identities = 71/175 (40%), Positives = 94/175 (53%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174 VA FYA KL++ H F NFF DF L K I EK DF + + Sbjct: 161 VAMFYAVKLESQHASNPIFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSL 220 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 K + KK+ + RK A ++ + LVDG E+ GN VEPP LFLGRG HP Sbjct: 221 KVAEAERKKSMAPSMRKAELAARRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGAHP 280 Query: 355 LTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G+VK RIQPE +T+N + P P+ P GH+WG+++ VTWLA W+++I G Sbjct: 281 KAGRVKTRIQPEQITINHSADHPPPK-PPKGHSWGEVVERKDVTWLALWRENING 334 [209][TOP] >UniRef100_UPI000069F011 UPI000069F011 related cluster n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069F011 Length = 503 Score = 128 bits (322), Expect = 2e-28 Identities = 62/165 (37%), Positives = 101/165 (61%) Frame = +1 Query: 25 LQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA 204 L ++ KE FR+N+F D+R + + VIT L KCDF+ + + + K EKK Sbjct: 2 LDHEYTTKEIFRNNYFMDWRKEMT-LEERMVITDLAKCDFTEMFTYYKG----KMEEKKN 56 Query: 205 QTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQ 384 ++ ++ + +E + ++++ +D E +GNF++EPP LF GRGDHP G +K+RI Sbjct: 57 KSKEDKLKIKEENEKLLQEYGYCSMDHHRERIGNFKIEPPALFRGRGDHPKQGMLKKRIL 116 Query: 385 PEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 PED+ +N ++ IPE P PGH W ++ H++ VTWLA W +++ G Sbjct: 117 PEDIIINCSKDSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQG 160 [210][TOP] >UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE Length = 725 Score = 128 bits (322), Expect = 2e-28 Identities = 71/173 (41%), Positives = 101/173 (58%), Gaps = 3/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 + T++A + + + KE +R NF + L TKF L+K DF++I HLE ++ Sbjct: 82 LCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIREHLEQQRL 134 Query: 181 ---KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 K E+K Q ER + R + ALVDG E VGN+ +E P LF GRG+H Sbjct: 135 LRLNKSDEQKKQEKLERDQ-------RELFYGYALVDGCLERVGNYTLEQPTLFKGRGEH 187 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDS 510 P G +K RI PE++T+NL AP+P+C +PGH+WGKI+H + VTWL + DS Sbjct: 188 PKAGLLKARIFPEELTVNLSTQAPVPQCKLPGHSWGKIVHRNDVTWLFSYVDS 240 [211][TOP] >UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR Length = 874 Score = 127 bits (318), Expect = 6e-28 Identities = 73/180 (40%), Positives = 102/180 (56%), Gaps = 8/180 (4%) Frame = +1 Query: 4 ATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIEA 159 ATF+ L T +V F+ NFF DF+ +L T AK I EK DFS++ A Sbjct: 280 ATFFGFMLNSTVNVENPTFQKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWA 339 Query: 160 HLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLG 339 + + + K A A+ AE+ E + +A + DGR+E VGN RVE P LF G Sbjct: 340 YKDAQTKAKNARSSAEKKAEKAERDKRDAP----YLYCKWDGRKEKVGNPRVEIPGLFRG 395 Query: 340 RGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 RGDHP TG +K+R+ PE +T+N+G A +PE P GH W + H++ TWLA W+++I G Sbjct: 396 RGDHPKTGCIKKRVLPEQITINIGKEAKVPE-PPAGHKWKAVQHDNKATWLAMWQENING 454 [212][TOP] >UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI Length = 638 Score = 126 bits (317), Expect = 8e-28 Identities = 69/172 (40%), Positives = 94/172 (54%) Frame = +1 Query: 4 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAK 183 ATFYA L + F NFF DFR L + K+I KC+F I + E K Sbjct: 120 ATFYAKMLNHECCRNRIFYRNFFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNK 178 Query: 184 KKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 + A K + A+RK+ V ++ LVDG E + NFR+EPP LF GRGDHP G Sbjct: 179 RLAATKEEKLAKRKKNEAF----VNKYGFCLVDGHRERISNFRLEPPGLFRGRGDHPKMG 234 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 +KRR+Q D+ +N G ++ IP P G W ++ H++ VTWLA W D++ G Sbjct: 235 MIKRRVQACDIIINCGRDSKIP-MPPRGQMWKEVRHDNTVTWLASWVDNVQG 285 [213][TOP] >UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE Length = 596 Score = 126 bits (317), Expect = 8e-28 Identities = 70/173 (40%), Positives = 102/173 (58%), Gaps = 3/173 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 + T++A + + + KE +R NF + L TKF L+K DF++I+ +LE ++ Sbjct: 82 LCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIKEYLEQQRL 134 Query: 181 ---KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDH 351 K E+K Q ER + R + ALVDG E VGN+ +E P LF GRG+H Sbjct: 135 LRLNKSDEQKKQEKLERDQ-------RELFYGYALVDGCLERVGNYTLEQPTLFKGRGEH 187 Query: 352 PLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDS 510 P G +K RI PE++T+NL AP+P+C +PGH+WGKI+H + VTWL + DS Sbjct: 188 PKAGLLKARIFPEELTVNLSTQAPVPQCKLPGHSWGKIVHRNDVTWLFSYVDS 240 [214][TOP] >UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7 Length = 839 Score = 125 bits (315), Expect = 1e-27 Identities = 71/179 (39%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIE----AH 162 +AT++ S + +D+ KEKF NFF F L + K T L+K D S + Sbjct: 193 LATYWCSAIGSDYCTKEKFILNFFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMP 252 Query: 163 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 342 ++D K + EK +T E++E ++ E+ +T ALVD E + + + EPP LF GR Sbjct: 253 IKDHLLKLREEKLNKTKEEKEEEKKMRMEKELPYTYALVDWIREKISSNKAEPPGLFRGR 312 Query: 343 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSI 513 G+HP G +K+RI PEDV +N+ +AP+P + GHNWG I H++ VTWLA +KDSI Sbjct: 313 GEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDNMCGHNWGDIYHDNKVTWLAYYKDSI 371 [215][TOP] >UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1 RepID=A9A2H9_NITMS Length = 551 Score = 125 bits (315), Expect = 1e-27 Identities = 77/172 (44%), Positives = 101/172 (58%), Gaps = 4/172 (2%) Frame = +1 Query: 13 YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK-- 186 +A K T + + F+ NF ADF L D+KF K+ S E DFS ++ EK K Sbjct: 44 WAKKKDTPYAQDKVFQKNFTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEM 100 Query: 187 --KAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K EKKA A+RKE RE E ++ VA++DG+E VGN+ EPP +F+GRG+HPL Sbjct: 101 MTKEEKKA-IAAKRKELRE---ELKSKYGVAVMDGKEVEVGNYMAEPPGIFIGRGEHPLR 156 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 G+ K R+ +DVTLNLG A +PE WGKIIH+ WLA W D +T Sbjct: 157 GRWKPRVTAKDVTLNLGKEAKVPE-----GKWGKIIHDKDSMWLASWMDFLT 203 [216][TOP] >UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio RepID=UPI0001A2BD10 Length = 349 Score = 125 bits (313), Expect = 2e-27 Identities = 66/154 (42%), Positives = 95/154 (61%), Gaps = 1/154 (0%) Frame = +1 Query: 55 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 234 FR F D + + + + K+IT+L KCDF+ I + +K EKK T KE Sbjct: 191 FRMFFACDCQEMTKEER--KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----KEVL 240 Query: 235 EAEAERV-RQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLG 411 + EA R+ +F L+DG E +GNF++EPP LF GRG+HP G++K+RIQPEDV +N Sbjct: 241 KDEAARLMEEFGYCLLDGHREKIGNFKLEPPGLFRGRGEHPKMGRLKKRIQPEDVAINCS 300 Query: 412 PNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 ++ IPE P GH W ++ H++ VTWLA W ++I Sbjct: 301 KDSKIPE-PPAGHKWKRVQHDNTVTWLASWLENI 333 [217][TOP] >UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO Length = 701 Score = 124 bits (310), Expect = 5e-27 Identities = 70/175 (40%), Positives = 100/175 (57%), Gaps = 4/175 (2%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTK-FAKVITSLEKCDFSRIEAHLEDEK 177 VATF+A + T++ E +R NF+ F ++ K +L+ CDFS I AHL+ E+ Sbjct: 153 VATFWAQSIGTNYEESEIYRRNFWNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHLDMER 212 Query: 178 AKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 KKK +K+ K +E A++ + ALVD E VG+ R+EPP LF GRG HP Sbjct: 213 EKKKEQKEYY-----KALKEETAKKEHPYCYALVDWIREKVGSNRMEPPGLFKGRGLHPK 267 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPV---PGHNWGKIIHNSCVTWLAGWKDSI 513 G +K R P V LNL +AP+P+ + GH W I H+S VTWLA ++D++ Sbjct: 268 QGLLKGRTFPHSVVLNLSKDAPVPKVSMFERQGHGWSDIFHDSSVTWLAYYRDTV 322 [218][TOP] >UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH Length = 713 Score = 123 bits (309), Expect = 7e-27 Identities = 70/188 (37%), Positives = 98/188 (52%), Gaps = 19/188 (10%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +AT+++ L TD K K+R NF F K +K DF+ I+ HLE++K Sbjct: 173 MATYWSQTLGTDWEHKPKYRENFSKQFLDTFGKDKGKY---DFDKFDFTPIKIHLEEQKE 229 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTV-ALVDGREETVGNFRVEPPNLFLGRGDHPL 357 +K K E K + + ER+ + A++DG E VG F +EPP LF GRG+HP Sbjct: 230 IRKNRSK-----EEKNQEKQKKERLSDYYAGAILDGFREKVGQFMIEPPTLFKGRGEHPK 284 Query: 358 TGKVKRRIQPEDVTLNLGPNAPIPECPVP------------------GHNWGKIIHNSCV 483 G +K RIQPE V +N+ +AP+P+C VP GH W +I+H V Sbjct: 285 MGMMKGRIQPEAVVINISKDAPVPKCSVPDCIHICRQIFNEFPKKQLGHGWSEIVHKQDV 344 Query: 484 TWLAGWKD 507 TWLA +KD Sbjct: 345 TWLASYKD 352 [219][TOP] >UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG RepID=B9Q6S5_TOXGO Length = 953 Score = 122 bits (307), Expect = 1e-26 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE--------- 132 VA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 345 VANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVG 404 Query: 133 --KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 306 CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD E VGN Sbjct: 405 FAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGN 460 Query: 307 FRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVT 486 RVEPP LF GRG+HP G +KRRI DV LNL +AP+P +PGH W + H++ VT Sbjct: 461 TRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVT 520 Query: 487 WLAGWKDSI 513 WLA ++DSI Sbjct: 521 WLAFYRDSI 529 [220][TOP] >UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1 RepID=B9PWF4_TOXGO Length = 953 Score = 122 bits (307), Expect = 1e-26 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE--------- 132 VA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 345 VANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVG 404 Query: 133 --KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 306 CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD E VGN Sbjct: 405 FAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGN 460 Query: 307 FRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVT 486 RVEPP LF GRG+HP G +KRRI DV LNL +AP+P +PGH W + H++ VT Sbjct: 461 TRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVT 520 Query: 487 WLAGWKDSI 513 WLA ++DSI Sbjct: 521 WLAFYRDSI 529 [221][TOP] >UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49 RepID=B6KM03_TOXGO Length = 953 Score = 122 bits (307), Expect = 1e-26 Identities = 70/189 (37%), Positives = 103/189 (54%), Gaps = 18/189 (9%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE--------- 132 VA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 345 VANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMVG 404 Query: 133 --KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGN 306 CDFS I+ +L+ K+K KK + E++ ++ + + + ALVD E VGN Sbjct: 405 FAACDFSPIKEYLD----KQKELKKEMSKEEKEILKQQKLQEGAPYAYALVDFIREKVGN 460 Query: 307 FRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVT 486 RVEPP LF GRG+HP G +KRRI DV LNL +AP+P +PGH W + H++ VT Sbjct: 461 TRVEPPGLFRGRGEHPKQGMLKRRIFSYDVILNLAEDAPVPRVALPGHAWKDVFHDNSVT 520 Query: 487 WLAGWKDSI 513 WLA ++DSI Sbjct: 521 WLAFYRDSI 529 [222][TOP] >UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L6G4_PLAKH Length = 924 Score = 121 bits (303), Expect = 3e-26 Identities = 68/179 (37%), Positives = 102/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITS--LEKCDFSRIE----AH 162 +AT++ S + +D+ KEKF NFF F L + L+K D S + Sbjct: 227 LATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDFMP 286 Query: 163 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 342 ++D K + EK +T E++E ++ +E+ T ALVD E + + + EPP LF GR Sbjct: 287 IKDHLVKLREEKLNRTKEEKEEEKKLRSEKELPHTYALVDWIREKISSNKAEPPGLFRGR 346 Query: 343 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSI 513 G+HP G +K+RI PEDV +N+ +AP+P + GH+WG I H++ VTWLA +KDSI Sbjct: 347 GEHPKQGLLKKRIFPEDVVINISKDAPVPRLYGDMCGHSWGDIYHDNKVTWLAYYKDSI 405 [223][TOP] >UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1 Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO Length = 886 Score = 119 bits (299), Expect = 9e-26 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDFSR 150 +AT++ S + TD+ K+KF NFF F L + I++ + DF Sbjct: 245 LATYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENENKIKNGDISNFKFIDFMT 304 Query: 151 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 330 I+ HL K + E+ +T E++E ++ E+ +T ALVD E + + + EPP L Sbjct: 305 IKEHL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREKISSNKAEPPGL 360 Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWK 504 F GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H++ VTWLA +K Sbjct: 361 FRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYK 420 Query: 505 DSI 513 DSI Sbjct: 421 DSI 423 [224][TOP] >UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax RepID=A5KB33_PLAVI Length = 931 Score = 119 bits (298), Expect = 1e-25 Identities = 67/179 (37%), Positives = 102/179 (56%), Gaps = 8/179 (4%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLEKCDFSRIE----AH 162 +AT++ S + +D+ KEKF NFF F L + + L+K D S + Sbjct: 227 LATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDFMP 286 Query: 163 LEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGR 342 ++D K + EK +T E++E ++ +E+ +T ALVD E + + + EPP LF GR Sbjct: 287 IKDHLVKLREEKLNRTKEEKEEEKKLRSEKELPYTYALVDWIREKISSNKAEPPGLFRGR 346 Query: 343 GDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSI 513 G+HP G +K+RI PEDV +N+ +AP+P + GH WG H++ VTWLA +KDSI Sbjct: 347 GEHPKQGLLKKRIFPEDVVINISKDAPVPRLYDDMCGHCWGDTYHDNKVTWLAYYKDSI 405 [225][TOP] >UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2) (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD Length = 620 Score = 119 bits (297), Expect = 2e-25 Identities = 63/171 (36%), Positives = 105/171 (61%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFY KL ++ KE F++NFF+D+R + + +VI L++CDF+ I H D Sbjct: 49 VATFYGKKLDREYT-KEVFQNNFFSDWRKEMTAEE-GRVIKHLDRCDFTEIHRHSVD--- 103 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 K A +KA + E+++ +E E + ++F +++DG E +G+F+ EP ++ GRGDHP Sbjct: 104 -KTASQKALSREEKQKLKEEEEKLQQEFGCSILDGHREKIGSFKTEPWSV-RGRGDHPKM 161 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 ++KRR+ PEDV +N ++ +PE P G W ++ + V WLA W +++ Sbjct: 162 ERLKRRVLPEDVVINCSRDSTVPE-PPAGPQWKEVGCDCTVMWLAAWTENV 211 [226][TOP] >UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi RepID=Q4XMK5_PLACH Length = 429 Score = 119 bits (297), Expect = 2e-25 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDFSR 150 +AT++ S + TD+ K+KF NFF F L + I++ + DF Sbjct: 220 LATYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDFMT 279 Query: 151 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 330 I+ HL K + E+ +T E++E ++ E+ +T ALVD E + + + EPP L Sbjct: 280 IKEHL----IKLRDERLNKTKEEKEEDKKIRMEKELPYTFALVDWIREKISSNKAEPPGL 335 Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWK 504 F GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H++ VTWLA +K Sbjct: 336 FRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYK 395 Query: 505 DSI 513 DSI Sbjct: 396 DSI 398 [227][TOP] >UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei RepID=Q4YYG2_PLABE Length = 805 Score = 118 bits (295), Expect = 3e-25 Identities = 69/183 (37%), Positives = 102/183 (55%), Gaps = 12/183 (6%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV----------ITSLEKCDFSR 150 +AT++ S + TD+ KEKF NFF F L + I++ + DF Sbjct: 190 LATYWCSVIGTDYCTKEKFILNFFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDFMT 249 Query: 151 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNL 330 I+ +L K + E+ +T E++E ++ E+ +T ALVD E + + + EPP L Sbjct: 250 IKENL----IKLREERLNKTKEEKEEEKKIRMEKELPYTFALVDWIREKISSNKAEPPGL 305 Query: 331 FLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPEC--PVPGHNWGKIIHNSCVTWLAGWK 504 F GRG+HP G +K+RI PEDV +N+ +AP P + GHNWG I H++ VTWLA +K Sbjct: 306 FRGRGEHPKQGLLKKRIFPEDVVINISKDAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYK 365 Query: 505 DSI 513 DSI Sbjct: 366 DSI 368 [228][TOP] >UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva RepID=Q4N5U3_THEPA Length = 1003 Score = 116 bits (291), Expect = 8e-25 Identities = 69/174 (39%), Positives = 99/174 (56%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +AT +A + T++ + + NF+ F + F + L DFS I+ HLEDEK Sbjct: 374 IATMWAQSIGTNYETSDIYCKNFWQVFVSKFEKDHFIRRC-KLTDVDFSLIKTHLEDEKQ 432 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK K+ K ++ +A+R +F ALVD E V + ++EPP LF GRG HP Sbjct: 433 KKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSSNKLEPPGLFKGRGLHPKQ 487 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K R+ P+DV LNL +AP+P+ GH+W I H++ VTWLA +KDSI Sbjct: 488 GLLKARMFPKDVILNLSKDAPVPKVSNFQREGHSWKDIYHDNSVTWLAYYKDSI 541 [229][TOP] >UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata RepID=Q4UDP8_THEAN Length = 999 Score = 116 bits (290), Expect = 1e-24 Identities = 69/174 (39%), Positives = 99/174 (56%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +AT +A + T++ E + NF+ F + F + L DFS I+ HLE+EK Sbjct: 375 IATMWAQSMGTNYETSEIYCKNFWQVFVSKFEKDHFIRRC-KLSDADFSLIKNHLEEEKQ 433 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KKK K+ K ++ +A+R +F ALVD E V + ++EPP LF GRG HP Sbjct: 434 KKKDNKEFY-----KAKQQEDAKREYRFNYALVDWVREKVSSNKLEPPGLFKGRGLHPKQ 488 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPEC---PVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +K R+ P+DV LNL +AP+P+ GH+W I H++ VTWLA +KDSI Sbjct: 489 GLLKSRMFPKDVILNLSKDAPVPKVTNFQREGHSWKDIYHDNSVTWLAYYKDSI 542 [230][TOP] >UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA Length = 790 Score = 116 bits (290), Expect = 1e-24 Identities = 69/174 (39%), Positives = 102/174 (58%), Gaps = 3/174 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A L+T+++ K KFR NF +D+R +L + +I +LE CDF+ I + EK Sbjct: 254 VATMFAVMLETEYMTKPKFRENFMSDWRKILGEKH---IIQNLEDCDFTPIYEWHQREKE 310 Query: 181 KKKAEKKAQTTAERKEAREAEAE-RVRQFTVALVDGRE-ETVGNFRVEPPNLFLGRGDHP 354 KKK +T E+K +E + E R ++ A+VDG E VGNFRV + Sbjct: 311 KKKQ----MSTDEKKAIKEGKDETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWRAS 366 Query: 355 LTGKVKRRIQPE-DVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 +VK+ + + D+T+N+G +APIPE P+PG W +I H++ VTWLA W D I Sbjct: 367 KDPQVKKNVYSQIDITINIGKDAPIPEPPIPGERWKEIRHDNTVTWLAFWNDPI 420 [231][TOP] >UniRef100_UPI000180B1AE PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Ciona intestinalis RepID=UPI000180B1AE Length = 482 Score = 114 bits (286), Expect = 3e-24 Identities = 52/132 (39%), Positives = 84/132 (63%) Frame = +1 Query: 118 ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREET 297 IT L KC+F + ++ + +K E+KA++ E++E ++ + +F DG E Sbjct: 10 ITDLGKCNFRDVCSYFQ----QKSEERKARSKEEKQEEKKKNEALIEEFGFCDWDGHREK 65 Query: 298 VGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNS 477 +GNFR+EPP LF GRG+HP GK+K+RI PE++T+N N+ IP+ P GH W ++ H++ Sbjct: 66 IGNFRLEPPGLFRGRGNHPKMGKLKKRIIPENITINCSKNSKIPK-PPAGHKWKEVRHDN 124 Query: 478 CVTWLAGWKDSI 513 VTWL W +++ Sbjct: 125 AVTWLVSWTENV 136 [232][TOP] >UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187E0BD Length = 265 Score = 107 bits (268), Expect = 4e-22 Identities = 59/138 (42%), Positives = 81/138 (58%), Gaps = 2/138 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDE 174 VA FYA+ ++TDH F NFF D+ +L D + +T +KCDF + + E E Sbjct: 123 VAGFYAALIETDHAQDATFNKNFFEDWLKVLQDHPPRNGIKVTDFDKCDFRPMYEYFEAE 182 Query: 175 KAKKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHP 354 KAKKKA + AE+KE ++ + E ++T +DGR+E VGNFRVEPP LF GRG+HP Sbjct: 183 KAKKKA----MSAAEKKEIKKQKDEAEAKYTHCFLDGRKEKVGNFRVEPPGLFRGRGEHP 238 Query: 355 LTGKVKRRIQPEDVTLNL 408 G +K P + L L Sbjct: 239 KKGSLKVIGSPSLIALGL 256 [233][TOP] >UniRef100_B3TAG0 Putative eukaryotic DNA topoisomerase I, catalytic core n=1 Tax=uncultured marine crenarchaeote HF4000_APKG8D22 RepID=B3TAG0_9ARCH Length = 563 Score = 107 bits (268), Expect = 4e-22 Identities = 56/161 (34%), Positives = 91/161 (56%) Frame = +1 Query: 34 DHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTT 213 D + ++ F S+F F + +++ + SL + ++ E+++ K +KKA Sbjct: 62 DSIFQKNFVSDFAKTFNGKFKNLQYSDIDFSLA---YQLVDKEKEEKELLTKEDKKA-LA 117 Query: 214 AERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPED 393 +RKE RE E ++ ++DG+E +GN+ EPP +F+GRG+HP+ G+ K R+ +D Sbjct: 118 IKRKEIRE---EMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKD 174 Query: 394 VTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 VTLNLG A IPE WGKI+H+ W+A W D +T Sbjct: 175 VTLNLGKEAKIPEA-----KWGKIVHDRNSMWIASWMDILT 210 [234][TOP] >UniRef100_B3T4E9 Putative eukaryotic DNA topoisomerase I, catalytic core n=1 Tax=uncultured marine crenarchaeote HF4000_ANIW133O4 RepID=B3T4E9_9ARCH Length = 563 Score = 106 bits (265), Expect = 8e-22 Identities = 61/157 (38%), Positives = 88/157 (56%), Gaps = 3/157 (1%) Frame = +1 Query: 55 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERK 225 F+ NF +DF A + KF + S DFS ++ EK +K+ E K +RK Sbjct: 65 FQKNFVSDF-AKTFNGKFKNLQYS--DIDFSLAHQLVDKEKEEKELLTKEDKKALAIKRK 121 Query: 226 EAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLN 405 E RE E ++ ++DG+E +GN+ EPP +F+GRG+HP+ G+ K R+ +DVTLN Sbjct: 122 EIRE---EMKAKYGNGIIDGKEVEIGNYMAEPPGIFMGRGEHPMRGRYKLRVTAKDVTLN 178 Query: 406 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT 516 LG A IPE WGKI+H+ W+A W D +T Sbjct: 179 LGKEAKIPEA-----KWGKIVHDRNSMWIASWMDILT 210 [235][TOP] >UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI Length = 557 Score = 103 bits (258), Expect = 5e-21 Identities = 60/175 (34%), Positives = 90/175 (51%), Gaps = 2/175 (1%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA L T V +F NFF DFR+ L+ + TS + C+F +I +LE Sbjct: 107 VATFYAKVLGTPFVELSEFNENFFKDFRSCLSVEQRLH-FTSFDLCNFQKIHQYLE---- 161 Query: 181 KKKAEKKAQTTAERKEAR-EAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPL 357 E++EAR + E E ++ +DG + FR++PP L R + L Sbjct: 162 ------------EQQEARSQQELEEDERYGYCYIDGERHRINQFRIKPPGLCCPRKGYSL 209 Query: 358 T-GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 T G ++ R+ PED+ +N A P P PGH W +++H+ V+WL W D ++G Sbjct: 210 TMGMIRPRVLPEDIMINCDEYAE-PPAPPPGHRWRQVVHDRSVSWLYSWHDLVSG 263 [236][TOP] >UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum RepID=A0RU10_CENSY Length = 519 Score = 103 bits (258), Expect = 5e-21 Identities = 63/170 (37%), Positives = 90/170 (52%), Gaps = 3/170 (1%) Frame = +1 Query: 13 YASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKA 192 +A K T + + F+ NF DF L K + DFS ++ EK KK Sbjct: 44 WAKKKDTPYAQDKVFQKNFARDFAKELGIKLLYKDL------DFSEAYRLVDMEKDKKDM 97 Query: 193 ---EKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTG 363 E+K + A+RKE RE + + +A++DG+E + ++ EPP +F+GRG HPL G Sbjct: 98 MTKEEKKEIAAKRKEIREGLKAK---YGIAVMDGKEVEIASYMAEPPGIFIGRGKHPLRG 154 Query: 364 KVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 K KRRI P+DV LN+G A P PG W KI+H W+A W D++ Sbjct: 155 KWKRRIGPQDVVLNMGTKAKAP----PG-KWKKIVHEKDGIWIAKWTDNL 199 [237][TOP] >UniRef100_UPI0000E48333 PREDICTED: similar to topoisomerase I alpha isoform 3, partial n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000E48333 Length = 440 Score = 100 bits (248), Expect = 8e-20 Identities = 45/98 (45%), Positives = 63/98 (64%) Frame = +1 Query: 226 EAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLTGKVKRRIQPEDVTLN 405 E + E +++ DG +E +GNFRVEPP+LF GRG+HP G++K+RI PEDV +N Sbjct: 1 ENKRKNEEIQKEYGFCSFDGHKEKIGNFRVEPPSLFRGRGEHPKQGQLKKRIGPEDVIIN 60 Query: 406 LGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 ++ P P GH W K+IH + VTWLA W ++I G Sbjct: 61 CSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQG 97 [238][TOP] >UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO Length = 555 Score = 97.8 bits (242), Expect = 4e-19 Identities = 57/174 (32%), Positives = 85/174 (48%), Gaps = 1/174 (0%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VATFYA ++T V +F NFF +FR+ L++ + + IT E C+F I +LE Sbjct: 104 VATFYAKLMKTAFVQMREFNQNFFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLE---- 158 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +R++ +E AE + + LVDG + FR+ P L R T Sbjct: 159 -----------CQREDEKERIAEENKLYGYCLVDGESRRITQFRISRPGLCCPRHGFSTT 207 Query: 361 -GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G ++ R+ PEDV +N N P P GH W ++H+ V W+ W D +TG Sbjct: 208 MGTIRPRVLPEDVVINCDENEE-PPAPPCGHLWAAVVHDRTVRWVYAWNDIVTG 260 [239][TOP] >UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN Length = 240 Score = 85.9 bits (211), Expect = 2e-15 Identities = 54/173 (31%), Positives = 85/173 (49%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 +AT YA + + + + F NFF DF++ L+ + I S E CDF++I +++ ++ Sbjct: 58 LATLYAKFMNSPLAITDTFNENFFKDFQSHLSRA-LRRQILSFELCDFTKIAFYIQGQQG 116 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 ++K T R + +DG+ V +F + P+L+ G P Sbjct: 117 ---VQRKLMTPMMRNH-----------YGYCTIDGKRHRVPHFSFDGPSLYRRSG--PKY 160 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 G VK RIQPEDV +N N P P GH W +IH+ V WL W D+++G Sbjct: 161 GMVKPRIQPEDVNINSQENGA-PGAP-DGHTWKSVIHDRRVDWLWSWTDALSG 211 [240][TOP] >UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major RepID=Q7YXA0_LEIMA Length = 200 Score = 81.6 bits (200), Expect = 3e-14 Identities = 54/124 (43%), Positives = 67/124 (54%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VAT +A + D+ E F NFF +R +L K I LE CDF I ++ Sbjct: 83 VATMFAVMKEHDYYRMEVFWRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQRE 140 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 KK + K + A KE ++AEAE R + DGR E V NFRVEPP LF GRG HPL Sbjct: 141 KKLSRTKEEKEAI-KEKQDAEAEPYRY---CVWDGRREQVANFRVEPPGLFRGRGKHPLM 196 Query: 361 GKVK 372 GK+K Sbjct: 197 GKLK 200 [241][TOP] >UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7 Length = 879 Score = 72.4 bits (176), Expect = 2e-11 Identities = 47/173 (27%), Positives = 76/173 (43%) Frame = +1 Query: 1 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 180 VA FYA ++ D+ K+ F +NF+ D++ ++ + A +I ++KC+F +I A+ + Sbjct: 420 VAGFYARMIEHDYTTKDVFNNNFYRDWKKVMTHEEKA-IIKDMKKCNFKQIHAYYQ---- 474 Query: 181 KKKAEKKAQTTAERKEAREAEAERVRQFTVALVDGREETVGNFRVEPPNLFLGRGDHPLT 360 +K E+KA + E Sbjct: 475 RKSEERKAMSKEE----------------------------------------------- 487 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG 519 K+RI PEDV +N ++ P P GH W K+IH + VTWLA W ++I G Sbjct: 488 ---KQRIGPEDVIINCSKDSKWP-IPPEGHKWKKVIHENSVTWLASWTENIQG 536 [242][TOP] >UniRef100_Q56XA9 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q56XA9_ARATH Length = 396 Score = 69.3 bits (168), Expect = 1e-10 Identities = 27/51 (52%), Positives = 38/51 (74%) Frame = +1 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G++K+RI P ++TLN+G APIPECP+ G W ++ H++ VTWLA W D I Sbjct: 1 GELKKRIHPCEITLNIGKGAPIPECPIAGERWKEVKHDNTVTWLAFWADPI 51 [243][TOP] >UniRef100_B4E061 cDNA FLJ51170, highly similar to DNA topoisomerase I, mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4E061_HUMAN Length = 477 Score = 55.5 bits (132), Expect = 2e-06 Identities = 25/51 (49%), Positives = 34/51 (66%) Frame = +1 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W +SI Sbjct: 2 GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESI 51 [244][TOP] >UniRef100_UPI0001AE6F94 UPI0001AE6F94 related cluster n=1 Tax=Homo sapiens RepID=UPI0001AE6F94 Length = 477 Score = 55.1 bits (131), Expect = 3e-06 Identities = 24/51 (47%), Positives = 34/51 (66%) Frame = +1 Query: 361 GKVKRRIQPEDVTLNLGPNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI 513 G +KRRI PEDV +N ++ IPE P GH W ++ ++ VTWLA W +S+ Sbjct: 2 GMLKRRITPEDVVINCSRDSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESV 51 [245][TOP] >UniRef100_B9Q1D7 Chloride channel, putative n=1 Tax=Toxoplasma gondii GT1 RepID=B9Q1D7_TOXGO Length = 1756 Score = 54.3 bits (129), Expect = 5e-06 Identities = 43/125 (34%), Positives = 53/125 (42%) Frame = -3 Query: 403 SASRPRAECGA*PYPSTDGPRDQGIGWAAPHGSCPPSLRDRPPERP*TDEHARPQPHGPP 224 S+S P + PS P ++P S PP PP P P P P Sbjct: 184 SSSSPSSSPSTSTSPSPSSPPSSSPPSSSPSSSSPPPSSSPPPSSP-------PSPSSAP 236 Query: 223 CARPSSAPSSPPSSSPFHPLSAPRSD*SHTFPGW*SPWQTWCPPGGL*SPRRSWIGTSPS 44 + S +PSSPPSSSP P SAP S T P SP + P SP S ++PS Sbjct: 237 SSSTSPSPSSPPSSSPPSPSSAPSSS---TSPSPSSPPPSSPPSSSSTSPSPS---SAPS 290 Query: 43 THGPS 29 + PS Sbjct: 291 SSPPS 295 [246][TOP] >UniRef100_B6KLS9 Voltage gated chloride channel domain-containing protein n=1 Tax=Toxoplasma gondii ME49 RepID=B6KLS9_TOXGO Length = 1779 Score = 53.5 bits (127), Expect = 8e-06 Identities = 44/129 (34%), Positives = 54/129 (41%), Gaps = 3/129 (2%) Frame = -3 Query: 409 PGSASRPRAECGA*PYPSTDGPRDQGIGWAAPHGSCPPSLRDRPPERP*TDEHARPQPHG 230 P S+S P + P PS+ P ++P S PP PP P P P Sbjct: 259 PPSSSSPSSSS---PPPSSSPPSSSPPSSSSPSSSSPPPSSSPPPPSP-PSSSTSPSPSS 314 Query: 229 PPCA---RPSSAPSSPPSSSPFHPLSAPRSD*SHTFPGW*SPWQTWCPPGGL*SPRRSWI 59 PP + PS PSSPPSSSP P S+P S S + P SP + P P S Sbjct: 315 PPSSSPPSPSPPPSSPPSSSP--PSSSPPSPPSPSSPPPSSPPSSSSPSSSSPPPSSSPP 372 Query: 58 GTSPSTHGP 32 SP + P Sbjct: 373 PPSPPSSSP 381