AU196004 ( PFL083e12_r )

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[1][TOP]
>UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA
          Length = 763

 Score =  203 bits (516), Expect = 6e-51
 Identities = 98/157 (62%), Positives = 119/157 (75%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGHNW ++ H++ VTWLA W +++    KYV+LSAGS+ KG SD  K+EKAR+LK  I
Sbjct: 322 PPPGHNWKEVRHDNTVTWLATWNENVNNNVKYVFLSAGSSLKGQSDLKKYEKARELKLYI 381

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
            +IRK+YRK    K  EVRQR+TA+YLID  ALR GNEK EDEADTVGCCSLR EH+  +
Sbjct: 382 DNIRKQYRKELEDKLMEVRQRATAMYLIDLFALRAGNEKGEDEADTVGCCSLRYEHISLS 441

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN 497
           PP TV FDFLGKDSIRY N V+VD  VF NL++F R+
Sbjct: 442 PPNTVVFDFLGKDSIRYYNEVQVDPQVFKNLKIFKRS 478

[2][TOP]
>UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum
           RepID=TOP1_DICDI
          Length = 893

 Score =  200 bits (508), Expect = 5e-50
 Identities = 92/166 (55%), Positives = 120/166 (72%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IP  P+PG  W +I+HN+ VTWLA W++S+ GG+KYVWL+  S  KG +D  KFE AR L
Sbjct: 485 IPPSPIPGEKWKEIVHNNTVTWLAFWRESVNGGFKYVWLAPSSKIKGQADRKKFEVARGL 544

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           K+CI  IRK Y+K +  +  E RQ + ALYLID LALRVGNEK ED+ADTVGCCSLRVEH
Sbjct: 545 KNCIGDIRKGYQKSFNDESTEKRQLAVALYLIDFLALRVGNEKGEDQADTVGCCSLRVEH 604

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSD 512
           +K     T++ DFLGKDS+RY N V++ +  +  L+ F + K+P+D
Sbjct: 605 IKLESNNTITLDFLGKDSMRYLNTVQIREDAYKVLKTFVKGKKPTD 650

[3][TOP]
>UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum RepID=Q94705_PHYPO
          Length = 1015

 Score =  197 bits (501), Expect = 4e-49
 Identities = 97/159 (61%), Positives = 116/159 (72%)
 Frame = +3

Query: 12   PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQ 191
            P+PE P PGH W K++H+  V WLA WK++I  G+KYVWL A SA KG SD  KFE AR+
Sbjct: 584  PVPE-PPPGHKWCKVVHDDKVAWLAMWKENINNGFKYVWLHASSAVKGRSDMKKFEVARK 642

Query: 192  LKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVE 371
            LK  I  IRK+Y K   ++  E RQR+TA+YLID+LALRVGNEK ED ADTVGCCSLRVE
Sbjct: 643  LKDHIEKIRKKYLKELGSEELEERQRATAIYLIDRLALRVGNEKDEDTADTVGCCSLRVE 702

Query: 372  HLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            H+    P +V+ DFLGKDS+RY N V+VD  VF NL  F
Sbjct: 703  HVTLKEPASVTLDFLGKDSMRYHNTVDVDPRVFKNLSEF 741

[4][TOP]
>UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe
           RepID=TOP1_SCHPO
          Length = 814

 Score =  196 bits (498), Expect = 8e-49
 Identities = 97/161 (60%), Positives = 117/161 (72%)
 Frame = +3

Query: 12  PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQ 191
           P+PE P+PGH W ++ H++ VTWLA W ++I    KYV+L+AGS+ KG SD  K+EK+R+
Sbjct: 370 PVPE-PLPGHQWAEVKHDNTVTWLATWHENINNNVKYVFLAAGSSLKGQSDLKKYEKSRK 428

Query: 192 LKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVE 371
           LK  I  IRK YRK   ++    RQR TA+YLID  ALR GNEK EDEADTVGCCSLR E
Sbjct: 429 LKDYIDDIRKGYRKDLKSELTVERQRGTAMYLIDVFALRAGNEKGEDEADTVGCCSLRYE 488

Query: 372 HLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
           H+   PP TV FDFLGKDSIRY N VEVD  VF NL++F R
Sbjct: 489 HVTLKPPRTVVFDFLGKDSIRYYNEVEVDPQVFKNLKIFKR 529

[5][TOP]
>UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata
           RepID=UPI000194D872
          Length = 775

 Score =  194 bits (493), Expect = 3e-48
 Identities = 96/170 (56%), Positives = 116/170 (68%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 405 PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 464

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 465 DKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 524

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 525 HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 574

[6][TOP]
>UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK
          Length = 766

 Score =  194 bits (493), Expect = 3e-48
 Identities = 96/170 (56%), Positives = 116/170 (68%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 396 PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 455

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 456 DKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 515

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 516 HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 565

[7][TOP]
>UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora
           DSM 70294 RepID=A7TJW1_VANPO
          Length = 799

 Score =  194 bits (493), Expect = 3e-48
 Identities = 99/172 (57%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           NAPIP  P  GH WG+I H++ V WLA W+++I+  +KYV L+A S+ KG SD  KFEKA
Sbjct: 351 NAPIPAVP-EGHKWGEIKHDNTVQWLAMWRENISNSFKYVRLAANSSLKGQSDFKKFEKA 409

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I SIRK+YR    +K    RQ++ A+YLID  ALR G EK++DEADTVGCCSLR
Sbjct: 410 RELKKYIDSIRKDYRTNLKSKLMLERQKAVAIYLIDVFALRAGGEKSDDEADTVGCCSLR 469

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP TV FDFLGKDSIR+   VEVDK VF NL +F R  K+P D +
Sbjct: 470 YEHVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLAIFKRAPKKPGDQL 521

[8][TOP]
>UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE
          Length = 596

 Score =  193 bits (491), Expect = 5e-48
 Identities = 96/172 (55%), Positives = 122/172 (70%), Gaps = 2/172 (1%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT--GGYKYVWLSAGSAFKGMSDHAKFEK 182
           AP+P+C +PGH+WGKI+H + VTWL  + DS      +KYV  +A S FK M+D  K+EK
Sbjct: 210 APVPQCKLPGHSWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYEK 269

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR+LK+ I  IR+ Y K   +   + RQ  TA YLIDKLALRVGNEK EDEADTVGCCSL
Sbjct: 270 ARRLKNQIDQIRENYTKKLQSDSIKERQLGTATYLIDKLALRVGNEKDEDEADTVGCCSL 329

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+K      V+FDFLGKDS+RY N V++   ++ NL+LF + KQP DN+
Sbjct: 330 RVEHIKLKEDDVVAFDFLGKDSMRYNNEVKLAHQIWKNLKLFIKGKQPEDNL 381

[9][TOP]
>UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus
           scrofa RepID=UPI00017EFDA4
          Length = 748

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 373 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 431

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 432 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 491

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 492 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 548

[10][TOP]
>UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus
           caballus RepID=UPI0001797824
          Length = 765

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 389 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 447

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 448 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 507

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 508 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 564

[11][TOP]
>UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta
           RepID=UPI00006D45A8
          Length = 767

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 391 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 449

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 450 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 509

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 510 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 566

[12][TOP]
>UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus
           RepID=UPI00006154BF
          Length = 769

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 393 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 451

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 452 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 511

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 512 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 568

[13][TOP]
>UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA
          Length = 560

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 184 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 242

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 243 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 302

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 303 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 359

[14][TOP]
>UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN
          Length = 765

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 389 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 447

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 448 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 507

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 508 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 564

[15][TOP]
>UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans
           RepID=Q5KB99_CRYNE
          Length = 881

 Score =  193 bits (490), Expect = 7e-48
 Identities = 99/171 (57%), Positives = 123/171 (71%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIP   +PG  W  I H++ VTWLA WK+++ G  KYV+LSAGSA+KG SD AKFEKAR
Sbjct: 435 APIPVPNIPGQ-WKGIQHDNTVTWLAHWKENVNGNAKYVFLSAGSAWKGQSDRAKFEKAR 493

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +L   +  IRK+Y     +K    RQR+TALY ID+LALR GNEK EDEADTVGCCSLR 
Sbjct: 494 ELIKHVDKIRKDYTADLKSKVMADRQRATALYFIDRLALRAGNEKGEDEADTVGCCSLRY 553

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
           EH+  +PP T+ FDFLGKDS+R+   VEVD  VF N++LF  + K+  D+I
Sbjct: 554 EHVTLSPPNTIIFDFLGKDSMRFHQEVEVDPQVFKNIKLFKADPKKKGDDI 604

[16][TOP]
>UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN
          Length = 765

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 389 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 447

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 448 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 507

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 508 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 564

[17][TOP]
>UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE
          Length = 767

 Score =  193 bits (490), Expect = 7e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 391 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 449

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 450 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 509

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 510 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 566

[18][TOP]
>UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica
            RepID=UPI0000F2B3E5
          Length = 916

 Score =  192 bits (489), Expect = 9e-48
 Identities = 97/177 (54%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 540  DAKVPP-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 598

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
            R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 599  RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 658

Query: 363  RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 659  RVEHINLHPEMDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 715

[19][TOP]
>UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans
           RepID=O59891_CRYNE
          Length = 844

 Score =  192 bits (489), Expect = 9e-48
 Identities = 99/171 (57%), Positives = 123/171 (71%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIP   +PG  W  I H++ VTWLA WK+++ G  KYV+LSAGSA+KG SD AKFEKAR
Sbjct: 398 APIPVPNIPGQ-WKGIQHDNTVTWLAHWKENVNGNAKYVFLSAGSAWKGQSDRAKFEKAR 456

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +L   +  IRK+Y     +K    RQR+TALY ID+LALR GNEK EDEADTVGCCSLR 
Sbjct: 457 ELIKHVDKIRKDYTADLKSKIMADRQRATALYFIDRLALRAGNEKGEDEADTVGCCSLRY 516

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
           EH+  +PP T+ FDFLGKDS+R+   VEVD  VF N++LF  + K+  D+I
Sbjct: 517 EHVTLSPPNTIIFDFLGKDSMRFHQEVEVDPQVFKNIKLFKADPKKKGDDI 567

[20][TOP]
>UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2
          Length = 745

 Score =  192 bits (487), Expect = 1e-47
 Identities = 97/172 (56%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH WG+I H++ V WLA W+++I   +KYV L+A S+ KG SD+ KFEKA
Sbjct: 297 DAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFEKA 355

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           RQLKS I +IR++Y +   +K    RQ++ A+YLID  ALR G EK+EDEADTVGCCSLR
Sbjct: 356 RQLKSYIDAIRRDYTRNLKSKVMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLR 415

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP TV FDFLGKDSIR+   VEVDK VF NL +F R  KQP   +
Sbjct: 416 YEHVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQL 467

[21][TOP]
>UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae
           RepID=TOP1_YEAST
          Length = 769

 Score =  192 bits (487), Expect = 1e-47
 Identities = 97/172 (56%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH WG+I H++ V WLA W+++I   +KYV L+A S+ KG SD+ KFEKA
Sbjct: 321 DAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFEKA 379

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           RQLKS I +IR++Y +   +K    RQ++ A+YLID  ALR G EK+EDEADTVGCCSLR
Sbjct: 380 RQLKSYIDAIRRDYTRNLKSKVMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLR 439

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP TV FDFLGKDSIR+   VEVDK VF NL +F R  KQP   +
Sbjct: 440 YEHVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQL 491

[22][TOP]
>UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae
           RepID=B3LJ50_YEAS1
          Length = 769

 Score =  191 bits (486), Expect = 2e-47
 Identities = 97/172 (56%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH WG+I H++ V WLA W+++I   +KYV L+A S+ KG SD+ KFEKA
Sbjct: 321 DAPVPPAP-EGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFEKA 379

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           RQLKS I +IR++Y +   +K    RQ++ A+YLID  ALR G EK+EDEADTVGCCSLR
Sbjct: 380 RQLKSYIDAIRRDYTRNLKSKLMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLR 439

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP TV FDFLGKDSIR+   VEVDK VF NL +F R  KQP   +
Sbjct: 440 YEHVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQL 491

[23][TOP]
>UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO
          Length = 910

 Score =  191 bits (485), Expect = 3e-47
 Identities = 95/172 (55%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECPVPG  W ++ H++ VTWLA W D I    +KYV+L+A S  KG+SD  K+EK
Sbjct: 534  DAPIPECPVPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSTLKGLSDKEKYEK 593

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
            AR LK  I  IR  Y K +A+K    +Q + A YLIDKLALR GNEK +DEADTVGCC+L
Sbjct: 594  ARLLKDYIQGIRAAYTKDFASKDPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 653

Query: 363  RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            +VE+++  PP  + FDFLGKDSIRY+N VEV+ AVF  +Q F   K+ S ++
Sbjct: 654  KVENVEPVPPNILKFDFLGKDSIRYQNEVEVEAAVFKAIQQFRSGKEGSSDL 705

[24][TOP]
>UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FNH4_CANGA
          Length = 744

 Score =  191 bits (485), Expect = 3e-47
 Identities = 95/163 (58%), Positives = 117/163 (71%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +APIP  P  GH+WG+I H++ V WLA WK++I G +KYV L+A S+  G SD  KFEKA
Sbjct: 296 DAPIPPAP-QGHHWGEIRHDNTVQWLAMWKENIFGSFKYVRLAANSSLNGQSDLKKFEKA 354

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+YR+ + +K    RQ++ A Y ID  ALR G EK+EDEADTVGCCSLR
Sbjct: 355 RELKKYIGDIRKDYRESFKSKIMLERQKAVATYFIDVFALRAGGEKSEDEADTVGCCSLR 414

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
            EH+   PP TV FDFLGKDSIRY   VEV+K VF NL++F R
Sbjct: 415 FEHVTLKPPNTVIFDFLGKDSIRYHQEVEVEKQVFKNLKIFKR 457

[25][TOP]
>UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FTA8_NANOT
          Length = 896

 Score =  191 bits (484), Expect = 3e-47
 Identities = 94/161 (58%), Positives = 117/161 (72%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH W ++ H+   TWLA W++++ G YKYV L+A S  KG SD+ KFEKA
Sbjct: 447 DAPVP-APPEGHRWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDVKGQSDYKKFEKA 505

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+KG   +    RQR+TA+YLID+ ALR GNEK EDEADTVGCCSL+
Sbjct: 506 RELKKHIDRIRKDYKKGLKDELMVNRQRATAVYLIDQFALRAGNEKGEDEADTVGCCSLK 565

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            EH+   PP TV FDFLGKDSIRY + VEVD  VF NL++F
Sbjct: 566 FEHVTLKPPNTVVFDFLGKDSIRYYDEVEVDPQVFKNLKIF 606

[26][TOP]
>UniRef100_UPI0000E48333 PREDICTED: similar to topoisomerase I alpha isoform 3, partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48333
          Length = 440

 Score =  190 bits (483), Expect = 4e-47
 Identities = 97/170 (57%), Positives = 115/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W K+IH + VTWLA W ++I G  KYV L+  S  KG  D AK+E AR+LK  +
Sbjct: 70  PPEGHKWKKVIHENSVTWLASWTENIQGAIKYVMLNPSSRIKGEKDWAKYETARKLKESV 129

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR EYR+ W +K   VRQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH++ 
Sbjct: 130 DRIRNEYREDWKSKEMRVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIQL 189

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDFLGKDSIRYEN+V V+K VF NL+LF  NK+  DN+
Sbjct: 190 YEEQDGMEFVVKFDFLGKDSIRYENSVPVEKRVFKNLKLFTENKKGEDNL 239

[27][TOP]
>UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1 Tax=Strongylocentrotus
            purpuratus RepID=UPI0000E471B7
          Length = 879

 Score =  190 bits (483), Expect = 4e-47
 Identities = 97/170 (57%), Positives = 115/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P  GH W K+IH + VTWLA W ++I G  KYV L+  S  KG  D AK+E AR+LK  +
Sbjct: 509  PPEGHKWKKVIHENSVTWLASWTENIQGAIKYVMLNPSSRIKGEKDWAKYETARKLKESV 568

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
              IR EYR+ W +K   VRQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH++ 
Sbjct: 569  DRIRNEYREDWKSKEMRVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIQL 628

Query: 384  TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                      V FDFLGKDSIRYEN+V V+K VF NL+LF  NK+  DN+
Sbjct: 629  YEEQDGMEFVVKFDFLGKDSIRYENSVPVEKRVFKNLKLFTENKKGEDNL 678

[28][TOP]
>UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0
          Length = 758

 Score =  190 bits (483), Expect = 4e-47
 Identities = 96/177 (54%), Positives = 118/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 382 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 440

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 441 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 500

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDF GKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 501 RVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 557

[29][TOP]
>UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT
          Length = 767

 Score =  190 bits (483), Expect = 4e-47
 Identities = 96/177 (54%), Positives = 118/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 391 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 449

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 450 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 509

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDF GKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 510 RVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 566

[30][TOP]
>UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE
          Length = 767

 Score =  190 bits (483), Expect = 4e-47
 Identities = 96/177 (54%), Positives = 118/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 391 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 449

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 450 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 509

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDF GKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 510 RVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 566

[31][TOP]
>UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus
            familiaris RepID=UPI00005A45B7
          Length = 1004

 Score =  190 bits (482), Expect = 6e-47
 Identities = 96/177 (54%), Positives = 118/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            +A +P  P  GH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 628  DAKVPSPPT-GHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 686

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
            R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 687  RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 746

Query: 363  RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 747  RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 803

[32][TOP]
>UniRef100_UPI000069F011 UPI000069F011 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069F011
          Length = 503

 Score =  190 bits (482), Expect = 6e-47
 Identities = 98/177 (55%), Positives = 122/177 (68%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P PGH W ++ H++ VTWLA W +++ G  KY+ L+A S  KG  D  K+E A
Sbjct: 127 DSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYEVA 185

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  + +IRK YR+ + +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 186 RKLKHHVVTIRKTYRENFKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 245

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+K  P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQ  D++
Sbjct: 246 RVEHIKLYPELDGDKYVVEFDFLGKDSIRYYNKVPVEKQVFKNLQLFMENKQEGDDL 302

[33][TOP]
>UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30
          Length = 752

 Score =  190 bits (482), Expect = 6e-47
 Identities = 96/177 (54%), Positives = 118/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P  GH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 376 DAKVPSPPT-GHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 434

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 435 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 494

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 495 RVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 551

[34][TOP]
>UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO
          Length = 732

 Score =  190 bits (482), Expect = 6e-47
 Identities = 98/172 (56%), Positives = 120/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +APIPE P  GH WG+I H++ V WL  W+++I+  +KYV L+A S+ KGMSD  KFEK+
Sbjct: 284 DAPIPEPPA-GHKWGEIRHDNTVQWLCMWRENISNSFKYVRLAANSSLKGMSDFKKFEKS 342

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK+ I  IR +YRK   +K    RQ + A YLID  ALR G EK+EDEADTVGCCSLR
Sbjct: 343 RELKNYIDIIRADYRKNLKSKVMLDRQIAVATYLIDVFALRAGGEKSEDEADTVGCCSLR 402

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP TV FDFLGKDSIRY   VEVDK VF NL +F R  K+P   +
Sbjct: 403 YEHISLKPPNTVVFDFLGKDSIRYYQEVEVDKQVFKNLSIFKRPPKEPGHQL 454

[35][TOP]
>UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143
           RepID=C6HAF8_AJECH
          Length = 909

 Score =  190 bits (482), Expect = 6e-47
 Identities = 91/154 (59%), Positives = 114/154 (74%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KFEKAR+LK  I
Sbjct: 466 PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGLSDYKKFEKARELKKHI 525

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+Y+KG   +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 526 DRIRKDYKKGLKHELMSERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 585

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 586 PPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 619

[36][TOP]
>UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR
           RepID=C0NC53_AJECG
          Length = 909

 Score =  190 bits (482), Expect = 6e-47
 Identities = 91/154 (59%), Positives = 114/154 (74%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KFEKAR+LK  I
Sbjct: 466 PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGLSDYKKFEKARELKKHI 525

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+Y+KG   +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 526 DRIRKDYKKGLKHELMSERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 585

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 586 PPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 619

[37][TOP]
>UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP
           RepID=B2WCA4_PYRTR
          Length = 905

 Score =  190 bits (482), Expect = 6e-47
 Identities = 98/167 (58%), Positives = 119/167 (71%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           NA +PE P  GH W +I H+   TWLA W+++I G YKYV L+A S  KG SD  KFEKA
Sbjct: 456 NAKVPEPPA-GHRWKEIKHDHEGTWLAMWQENINGAYKYVMLAANSDIKGQSDFKKFEKA 514

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+YRK   +K    RQR+TA+YLID+ ALR GNEK EDEADTVGCCSL+
Sbjct: 515 RELKKHIDRIRKDYRKDLNSKMMADRQRATAIYLIDQFALRAGNEKGEDEADTVGCCSLK 574

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQP 506
            +H+   PP TV FDFLGKDSIR+ + V+VD  VF NL+LF   K+P
Sbjct: 575 FQHITLRPPETVIFDFLGKDSIRFYDEVKVDPQVFKNLKLF--KKEP 619

[38][TOP]
>UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus
           NAm1 RepID=A6R590_AJECN
          Length = 651

 Score =  190 bits (482), Expect = 6e-47
 Identities = 91/154 (59%), Positives = 114/154 (74%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W +I H+   TWLA W++++ G YKYV L+A S  KG+SD+ KFEKAR+LK  I
Sbjct: 466 PPPGHKWKEIKHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGLSDYKKFEKARELKKHI 525

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+Y+KG   +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 526 DRIRKDYKKGLKHELMSERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKFEHVTLK 585

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 586 PPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 619

[39][TOP]
>UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC
          Length = 852

 Score =  189 bits (481), Expect = 7e-47
 Identities = 94/171 (54%), Positives = 120/171 (70%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
            APIPECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EKA
Sbjct: 504  APIPECPIPGERWKEVRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDKEKYEKA 563

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+LK  I  IR  Y K + +K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 564  RRLKDYIEGIRSAYTKDFTSKDPVKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 623

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VE+++  PP  + FDFLGKDSIRY+N V V K VF  +QLF   K+  D++
Sbjct: 624  VENVEPVPPNILKFDFLGKDSIRYQNEVAVYKPVFKAIQLFRSGKKGGDDL 674

[40][TOP]
>UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5LJG7_9ALVE
          Length = 551

 Score =  189 bits (481), Expect = 7e-47
 Identities = 92/172 (53%), Positives = 120/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP P CPVPGH +  ++H+  VTWLA + D+I    KYV+L+A S FKG SD  K+EKA
Sbjct: 266 DAPAPRCPVPGHAYKDVVHDPAVTWLAWFTDTINNQVKYVFLNAASGFKGQSDWLKYEKA 325

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
           R+LK  I  IR +Y K   +   + ++  TA+YLID+LALRVGNEK  E+EADTVGCCSL
Sbjct: 326 RKLKKYIRGIRDDYTKKMKSSDDDEKELGTAVYLIDRLALRVGNEKNTEEEADTVGCCSL 385

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+ F     ++ DFLGKDSIRY N V+VD  V+ NL+  C+ ++P D I
Sbjct: 386 RVEHMTFEADNKITLDFLGKDSIRYLNTVQVDPLVYKNLKTLCKARKPEDMI 437

[41][TOP]
>UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI
          Length = 760

 Score =  189 bits (481), Expect = 7e-47
 Identities = 91/159 (57%), Positives = 114/159 (71%)
 Frame = +3

Query: 12  PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQ 191
           P+PE P  GH WG++ H++ V WLA W ++I    KYV  +A S+ KGMSD+ KFEKAR+
Sbjct: 317 PVPEPPA-GHKWGEVRHDNSVAWLAMWHENINNSIKYVLFAANSSLKGMSDYKKFEKARE 375

Query: 192 LKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVE 371
           LK  +A+IRK+Y K   ++    RQR+TA+YLID LALR G EK +DEADTVGCCSLR E
Sbjct: 376 LKKHVATIRKDYEKELKSEAMFERQRATAMYLIDVLALRAGGEKGDDEADTVGCCSLRYE 435

Query: 372 HLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           H+  +PP  V FDFLGKDSIRY   VEV   VF NL++F
Sbjct: 436 HITLSPPNIVEFDFLGKDSIRYHQEVEVSPQVFKNLRIF 474

[42][TOP]
>UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155C8C4
          Length = 781

 Score =  189 bits (480), Expect = 1e-46
 Identities = 94/170 (55%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 411 PPPGHRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 470

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 471 DKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 530

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDFLGKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 531 HTEMDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 580

[43][TOP]
>UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5L755_9ALVE
          Length = 647

 Score =  189 bits (480), Expect = 1e-46
 Identities = 92/172 (53%), Positives = 120/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP P CPVPGH +  ++H+  VTWLA + D+I    KYV+L+A S FKG SD  K+EKA
Sbjct: 266 DAPAPRCPVPGHAYKDVVHDPAVTWLAWFTDTINNQVKYVFLNAASGFKGQSDWLKYEKA 325

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
           R+LK  I  IR +Y K   +   + ++  TA+YLID+LALRVGNEK  E+EADTVGCCSL
Sbjct: 326 RKLKKYIRGIRDDYTKKMKSTDDDEKELGTAVYLIDRLALRVGNEKNTEEEADTVGCCSL 385

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+ F     ++ DFLGKDSIRY N V+VD  V+ NL+  C+ ++P D I
Sbjct: 386 RVEHMTFEADNKITLDFLGKDSIRYLNTVQVDPLVYKNLKALCKARKPEDMI 437

[44][TOP]
>UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8IDM1_CHLRE
          Length = 586

 Score =  189 bits (479), Expect = 1e-46
 Identities = 93/164 (56%), Positives = 114/164 (69%), Gaps = 1/164 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAGSAFKGMSDHAKFEK 182
           N P+PE P PG  W ++ H+  VTWLA WKD+I T  YKYV+L A S FK  SD AK+EK
Sbjct: 199 NEPVPEHPYPGQTWKEVKHDHTVTWLAYWKDTISTKDYKYVFLGATSTFKADSDLAKYEK 258

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR+LK  I  +RK Y + W +  +  RQ   A+Y IDKLALR G+EK EDEADTVGCC+L
Sbjct: 259 ARKLKEIIVDVRKNYERDWDSSDQRKRQMGVAMYFIDKLALRAGHEKDEDEADTVGCCTL 318

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
           +VE+++      V FDFLGKDSIRYEN VEVD  V+ NL+ F R
Sbjct: 319 KVENIEIMGDNKVKFDFLGKDSIRYENIVEVDPRVYKNLEKFKR 362

[45][TOP]
>UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera
            RepID=UPI0000DB758E
          Length = 973

 Score =  188 bits (478), Expect = 2e-46
 Identities = 97/169 (57%), Positives = 113/169 (66%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PGH W +I H+  VTWLA W ++I G  KYV L+  S  KG  D  K+E AR+L   I
Sbjct: 621  PPPGHKWKEIRHDPNVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYEIARKLAQLI 680

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL--- 377
              IR EYR+ W +K   +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+   
Sbjct: 681  DKIRAEYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHITLH 740

Query: 378  --KFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
              K      V FDFLGKDSIRY N V V+K VF NLQLF  NK PSD++
Sbjct: 741  EQKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLQLFMENKSPSDDL 789

[46][TOP]
>UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus
           norvegicus RepID=UPI0001B7BF13
          Length = 760

 Score =  188 bits (478), Expect = 2e-46
 Identities = 95/175 (54%), Positives = 117/175 (66%), Gaps = 4/175 (2%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 389 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 447

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 448 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 507

Query: 363 RVEHLKFTPPT---TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P      V FDF GKDSIRY N V V+K VF NLQ F  NKQP D++
Sbjct: 508 RVEHINLHPELDGHVVEFDFPGKDSIRYYNKVPVEKRVFKNLQPFMENKQPEDDL 562

[47][TOP]
>UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5FAF
          Length = 573

 Score =  188 bits (478), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 203 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 262

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 263 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 322

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 323 YPKLDDQEYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDL 372

[48][TOP]
>UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F98
          Length = 790

 Score =  188 bits (478), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 389 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 448

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 449 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 508

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 509 YPKLDDQEYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDL 558

[49][TOP]
>UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F97
          Length = 790

 Score =  188 bits (478), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 435 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 494

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 495 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 554

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 555 YPKLDDQEYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDL 604

[50][TOP]
>UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F96
          Length = 767

 Score =  188 bits (478), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 397 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 456

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 457 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 516

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 517 YPKLDDQEYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDL 566

[51][TOP]
>UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU
          Length = 767

 Score =  188 bits (478), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 397 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 456

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 457 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 516

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 517 YPKLDDQEYVVEFDFLGKDSIRYYNRIPVEKRVFKNLQLFLENKQPGDDL 566

[52][TOP]
>UniRef100_A9T368 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T368_PHYPA
          Length = 502

 Score =  188 bits (478), Expect = 2e-46
 Identities = 91/172 (52%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
           +AP+PECP+PG  W ++ H++ VTWLA WKD I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 129 DAPVPECPIPGQKWKEVRHDNTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMLKYEK 188

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR LK  I +IR+ Y K +++     +Q + A YLID+LALR GNEK EDEADTVGCCSL
Sbjct: 189 ARTLKDYIDNIRRTYTKDFSSSDPTKQQIAVATYLIDRLALRAGNEKDEDEADTVGCCSL 248

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           +VEH+    P ++ FDFLGKDSIRY N VEVD+ V+  +  F + K+  D++
Sbjct: 249 KVEHVSLIAPKSLQFDFLGKDSIRYFNTVEVDERVYKAIGQFKKGKKGGDDL 300

[53][TOP]
>UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea
           okayama7#130 RepID=A8N6Y9_COPC7
          Length = 863

 Score =  188 bits (478), Expect = 2e-46
 Identities = 95/170 (55%), Positives = 116/170 (68%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IP   +PG  W K+IH++ VTWLA W ++I   +KYV+L+AGS  KG SD  KFEKAR
Sbjct: 434 AKIPVPNIPG-KWKKVIHDNTVTWLATWTENINNSHKYVFLAAGSRLKGQSDMQKFEKAR 492

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK  I  IR +Y +    K    RQR+TA+Y IDKLALR GNEK EDEADTVGCCSLR 
Sbjct: 493 ELKDHIEKIRADYTEDLRNKVMAHRQRATAMYFIDKLALRAGNEKGEDEADTVGCCSLRC 552

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           EH+   PP  + FDFLGKDSIRY   V VD  VF N+++F   K+  DN+
Sbjct: 553 EHVTLRPPNEIVFDFLGKDSIRYFKEVPVDAQVFKNIRIFKEGKELEDNL 602

[54][TOP]
>UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B1
          Length = 751

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 381 PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 440

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 441 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 500

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NK+P D++
Sbjct: 501 YPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKEPDDDL 550

[55][TOP]
>UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B0
          Length = 751

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 381 PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 440

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 441 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 500

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NK+P D++
Sbjct: 501 YPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKEPDDDL 550

[56][TOP]
>UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1DB6
          Length = 770

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 400 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 459

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 460 DRIRTQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 519

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 520 YPKLDDQEFVVEFDFLGKDSIRYYNKIPVEKRVFKNLQLFLENKQPGDDL 569

[57][TOP]
>UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5C65
          Length = 755

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 385 PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 444

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 445 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 504

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NK+P D++
Sbjct: 505 YPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKEPDDDL 554

[58][TOP]
>UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU
          Length = 753

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 383 PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 442

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 443 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 502

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NK+P D++
Sbjct: 503 YPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKEPDDDL 552

[59][TOP]
>UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG
          Length = 783

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 381 PPPGTKWKEVRHDNKVTWLASWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 440

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+  
Sbjct: 441 DRIRTQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL 500

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQP D++
Sbjct: 501 YPKLDDQEFVVEFDFLGKDSIRYYNKIPVEKRVFKNLQLFLENKQPGDDL 550

[60][TOP]
>UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG
          Length = 806

 Score =  188 bits (477), Expect = 2e-46
 Identities = 93/170 (54%), Positives = 114/170 (67%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 386 PPPGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 445

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+K 
Sbjct: 446 DRIRNQYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIKL 505

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  NK+P D++
Sbjct: 506 YPEIDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKEPDDDL 555

[61][TOP]
>UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC
          Length = 894

 Score =  188 bits (477), Expect = 2e-46
 Identities = 94/172 (54%), Positives = 123/172 (71%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG +W +I H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 520  DAPIPECPIPGESWKEIRHDNTVTWLAFWNDPIKPREFKYVFLAASSSLKGQSDKEKYEK 579

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
            AR LK  I  IR  Y K +A+K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L
Sbjct: 580  ARLLKDFIQGIRAAYTKDFASKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 639

Query: 363  RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            +VE+++  PP+ + FDFLGKDSIRY+N VEV+  V+  +Q F   K+  D++
Sbjct: 640  KVENVEPKPPSILKFDFLGKDSIRYQNEVEVELPVYKAIQQFRTGKRGGDDL 691

[62][TOP]
>UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FVE9_CANGA
          Length = 717

 Score =  188 bits (477), Expect = 2e-46
 Identities = 97/171 (56%), Positives = 119/171 (69%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIP  P  GH WG+I H++ V WLA W+++I G +KYV L+A S+ KG SD  KFEKAR
Sbjct: 270 APIPP-PPSGHQWGEIRHDNTVQWLAMWRENIFGSFKYVRLAANSSLKGQSDFKKFEKAR 328

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK  I  IRKEYR  + +K    RQ++ A+YLID  ALR G EK+E+EADTVGCCSLR 
Sbjct: 329 ELKKHIDRIRKEYRNNFKSKLMVERQKAVAVYLIDVFALRAGGEKSEEEADTVGCCSLRY 388

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
           EH+   PP TV FDFLGKDSIR+   V+VD  VF NL LF +  KQP   +
Sbjct: 389 EHITLKPPNTVIFDFLGKDSIRFYQEVQVDPKVFKNLALFKKPPKQPGHQL 439

[63][TOP]
>UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR
          Length = 767

 Score =  188 bits (477), Expect = 2e-46
 Identities = 95/177 (53%), Positives = 117/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 391 DAKVPS-PPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 449

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR +YR+ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTV CCSL
Sbjct: 450 RRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVSCCSL 509

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+   P        V FDF GKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 510 RVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL 566

[64][TOP]
>UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa
            RepID=B9I1A0_POPTR
          Length = 860

 Score =  187 bits (476), Expect = 3e-46
 Identities = 92/172 (53%), Positives = 124/172 (72%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIP+CP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 486  DAPIPKCPIPGERWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEK 545

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
            AR+LK  I +IR  Y K +A+K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L
Sbjct: 546  ARKLKDYIHNIRTAYTKDFASKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 605

Query: 363  RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            +V +++  PP  + FDFLGKDSIRYEN VEV+  V+  ++ F   K+P+D++
Sbjct: 606  KVANVECIPPNKLKFDFLGKDSIRYENTVEVELPVYKAIRQFQVAKKPTDDL 657

[65][TOP]
>UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GB81_AJEDR
          Length = 911

 Score =  187 bits (476), Expect = 3e-46
 Identities = 92/161 (57%), Positives = 117/161 (72%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKA
Sbjct: 462 DAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKFEKA 520

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+
Sbjct: 521 RELKKHIDRIRKDYKKSLKHELMSERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLK 580

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            EH+   PP+TV FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 581 YEHVTLKPPSTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 621

[66][TOP]
>UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JVV4_UNCRE
          Length = 889

 Score =  187 bits (476), Expect = 3e-46
 Identities = 92/154 (59%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 464 PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKFEKARELKKHI 523

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+YRKG   +    RQR+TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 524 DRIRKDYRKGLKDELTANRQRATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 583

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + VEVD  VF NL+ F
Sbjct: 584 PPNKVIFDFLGKDSIRFYDEVEVDHQVFKNLKFF 617

[67][TOP]
>UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1
            Tax=Tribolium castaneum RepID=UPI00017582B6
          Length = 936

 Score =  187 bits (475), Expect = 4e-46
 Identities = 94/176 (53%), Positives = 117/176 (66%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            ++ IPE P PGH W ++ H+  VTWLA W +++    KY+ L+  S  KG  D  K+E A
Sbjct: 562  DSKIPE-PPPGHKWKEVRHDDNVTWLASWTENVQNQVKYIMLNPSSKLKGEKDWQKYETA 620

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+L  CI  IR+EY+  W +K   +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLR
Sbjct: 621  RRLHKCIDKIREEYKDDWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLR 680

Query: 366  VEHL-----KFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VEH+     K      V FDFLGKDSIRY N V V+K VF NLQLF  +K P D++
Sbjct: 681  VEHISLHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLQLFMEHKSPGDDL 736

[68][TOP]
>UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66
           RepID=B6ABX7_9CRYT
          Length = 660

 Score =  187 bits (474), Expect = 5e-46
 Identities = 96/175 (54%), Positives = 125/175 (71%), Gaps = 4/175 (2%)
 Frame = +3

Query: 6   NAPIP--ECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP+P  +  + GH W  + H+S VTWLA +KDSI   +KY++LSA S FKGMSD+ K+E
Sbjct: 224 DAPVPKVDSSIIGHAWKDVFHDSNVTWLAYYKDSINNQFKYIFLSASSGFKGMSDYNKYE 283

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
           KAR+LK+ I +IR +Y K   +     RQ  TA YLID LALRVG EK  E+EADTVGCC
Sbjct: 284 KARKLKNFIHAIRDDYNKKMKSNDIIHRQLGTATYLIDFLALRVGGEKDIEEEADTVGCC 343

Query: 357 SLRVEHLKFTPPT-TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           SLRVEH+ F   + +++ DFLGKDSIRY N V +D A F+NL LFC+NK+  +N+
Sbjct: 344 SLRVEHISFNEDSKSITLDFLGKDSIRYFNTVCIDAAAFYNLMLFCKNKEKHENV 398

[69][TOP]
>UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG
          Length = 763

 Score =  187 bits (474), Expect = 5e-46
 Identities = 96/172 (55%), Positives = 120/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +APIP  P  GH W +I H++ V WLA W++++T   KYV  +A S+ KG SD  KFEKA
Sbjct: 315 DAPIPP-PPEGHQWKEIKHDNTVAWLATWRENVTNTVKYVLFAADSSLKGRSDFKKFEKA 373

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K +++K    RQ + A YLID  ALR G EKAEDEADTVGCCSLR
Sbjct: 374 RELKKYIHRIRKDYKKNFSSKVMLERQMAVATYLIDVFALRAGGEKAEDEADTVGCCSLR 433

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            EH+   PP TV FDFLGKDSIRY   V V + VF NL+LF ++ KQP D++
Sbjct: 434 YEHVTLKPPNTVVFDFLGKDSIRYYQEVNVHEKVFKNLRLFKKSPKQPGDDL 485

[70][TOP]
>UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224
           RepID=B6QNQ2_PENMQ
          Length = 860

 Score =  186 bits (473), Expect = 6e-46
 Identities = 92/161 (57%), Positives = 116/161 (72%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P  GH W ++ H+   TWLA W++++ G YKYV L+A S  KG SD+ KFEKA
Sbjct: 411 DAKVPP-PPEGHKWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGQSDYKKFEKA 469

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IR++YRKG  +     RQR+TA+YLIDK ALR GNEK EDEADTVGCCSL+
Sbjct: 470 RELKKHIDKIREDYRKGLKSDLMADRQRATAVYLIDKFALRAGNEKGEDEADTVGCCSLK 529

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            E++   PP TV FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 530 YENISLRPPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 570

[71][TOP]
>UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E5D8
          Length = 961

 Score =  186 bits (472), Expect = 8e-46
 Identities = 94/176 (53%), Positives = 118/176 (67%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            ++ IP+ P  GH W K+ H+  VTWLA W +++ G  KYV L+  S  KG  D  K+E A
Sbjct: 593  DSKIPK-PPDGHKWKKVQHDPSVTWLASWTENVQGNVKYVMLNPSSKLKGEKDMVKYETA 651

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+L   I  IR++Y+  W +K  ++RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLR
Sbjct: 652  RKLAKKIDKIREQYQADWKSKEMKIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLR 711

Query: 366  VEHLKFTP-----PTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VEH++  P        V FDFLGKDSIRY N V V+K VF NL LF  NKQP D++
Sbjct: 712  VEHVELYPELNGKENVVVFDFLGKDSIRYYNEVPVEKRVFKNLLLFKENKQPQDDL 767

[72][TOP]
>UniRef100_Q4V7M4 MGC115546 protein n=1 Tax=Xenopus laevis RepID=Q4V7M4_XENLA
          Length = 503

 Score =  186 bits (472), Expect = 8e-46
 Identities = 97/177 (54%), Positives = 120/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P PGH W ++ H++ VTWLA W +++ G  KY+ L+A S  KG  D  K+E A
Sbjct: 127 DSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYEIA 185

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK     IRK YR+ + +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 186 RKLKHHAEKIRKTYRENFKSKEMKVRQRAVALYFIDKLALRAGNEKEEGESADTVGCCSL 245

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+K  P        V FDFLGKDSIRY N V V+K VF NLQLF  NK+  D++
Sbjct: 246 RVEHIKLYPELDGEKHVVEFDFLGKDSIRYYNKVPVEKQVFKNLQLFMENKEEGDDL 302

[73][TOP]
>UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus
           RepID=A5E508_LODEL
          Length = 849

 Score =  186 bits (472), Expect = 8e-46
 Identities = 94/169 (55%), Positives = 122/169 (72%), Gaps = 1/169 (0%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IPE P  GH+W ++ H++ VTWLA WK++I+  +KYV  +A S+ KG SD  KFEKAR+L
Sbjct: 405 IPEPPA-GHHWAEVRHDNEVTWLAMWKENISDSFKYVRFAANSSVKGQSDFKKFEKAREL 463

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           +  + +IRK+Y K   ++  + RQ +TA+YLID  ALR G EK EDEADTVGCCSLR EH
Sbjct: 464 RQHVDAIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLRYEH 523

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
           L   PP  V FDFLGKDSIR+   VEVDK VF NL++F ++ K+P D+I
Sbjct: 524 LTLKPPNQVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKDPKRPGDDI 572

[74][TOP]
>UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis
           RepID=Q5CN58_CRYHO
          Length = 641

 Score =  186 bits (471), Expect = 1e-45
 Identities = 95/175 (54%), Positives = 123/175 (70%), Gaps = 4/175 (2%)
 Frame = +3

Query: 6   NAPIPECP--VPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP+P+ P  + GH W  I H++ VTWLA ++DSI   +KY++LSA S FKGMSD+ K+E
Sbjct: 216 DAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRDSINNQFKYIFLSASSGFKGMSDYNKYE 275

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
           KAR+LK  I +IR +YRK   +     RQ  TA YLID LALRVG EK  ++EADTVGCC
Sbjct: 276 KARKLKDHIDAIRSDYRKKMTSGDITQRQLGTATYLIDFLALRVGGEKDTDEEADTVGCC 335

Query: 357 SLRVEHLKFT-PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           SLRVEH+ F     +++ DFLGKDSIRY N V +D + F NL +FCRNK   +N+
Sbjct: 336 SLRVEHITFNQQEKSITLDFLGKDSIRYYNTVVIDPSAFNNLTIFCRNKDKMENV 390

[75][TOP]
>UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis
           RepID=A4HB62_LEIBR
          Length = 637

 Score =  186 bits (471), Expect = 1e-45
 Identities = 94/168 (55%), Positives = 113/168 (67%), Gaps = 2/168 (1%)
 Frame = +3

Query: 21  ECPVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           E PVP  GH WG + H+  VTWLA W+DS+ G  KYV L+A S+ KG SD  KFEKAR+L
Sbjct: 217 EVPVPPAGHKWGAVQHDHTVTWLAMWRDSVVGNAKYVMLAASSSVKGQSDMMKFEKARKL 276

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           K  +  IR  Y + + +    V QR+ A+Y ID+LALRVGNEK EDEADTVGCCSLRVEH
Sbjct: 277 KDKVDDIRASYMEDFKSNDVHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEH 336

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           ++      V FDFLGKDSIRY+N V V   V+  LQ F R K P  +I
Sbjct: 337 IQLMSDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGTDI 384

[76][TOP]
>UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01
           RepID=C1H484_PARBA
          Length = 900

 Score =  186 bits (471), Expect = 1e-45
 Identities = 90/154 (58%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 457 PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKFEKARELKKHI 516

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IR +Y+KG   +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 517 DRIRSDYKKGLKQELMAERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 576

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIRY + VEVD  VF NL++F
Sbjct: 577 PPNTVIFDFLGKDSIRYYDEVEVDPQVFKNLKIF 610

[77][TOP]
>UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18
           RepID=C1GKM6_PARBD
          Length = 825

 Score =  186 bits (471), Expect = 1e-45
 Identities = 90/154 (58%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 462 PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKFEKARELKKHI 521

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IR +Y+KG   +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 522 DRIRSDYKKGLKQELMAERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 581

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIRY + VEVD  VF NL++F
Sbjct: 582 PPNTVIFDFLGKDSIRYYDEVEVDPQVFKNLKIF 615

[78][TOP]
>UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0SEQ3_PARBP
          Length = 905

 Score =  186 bits (471), Expect = 1e-45
 Identities = 90/154 (58%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 462 PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDYKKFEKARELKKHI 521

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IR +Y+KG   +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 522 DRIRSDYKKGLKQELMAERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 581

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIRY + VEVD  VF NL++F
Sbjct: 582 PPNTVIFDFLGKDSIRYYDEVEVDPQVFKNLKIF 615

[79][TOP]
>UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST
          Length = 780

 Score =  186 bits (471), Expect = 1e-45
 Identities = 93/171 (54%), Positives = 124/171 (72%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IPE P PGH+WG+I +++ VTWLA W+++I   +KYV  +A S+ KG+SD  KFE AR
Sbjct: 332 AKIPEAP-PGHSWGEIKNDNTVTWLAMWRENIADSFKYVRFAASSSIKGVSDFKKFETAR 390

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +L+S + +IRK+Y K   ++  + RQ ++A+YLID  ALR G EK +DEADTVGCCSLR 
Sbjct: 391 RLRSHVDAIRKDYTKMLKSELMQDRQMASAIYLIDVFALRAGGEKGDDEADTVGCCSLRY 450

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
           EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F +  KQP D++
Sbjct: 451 EHITLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKAPKQPGDDL 501

[80][TOP]
>UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium
           parvum Iowa II RepID=Q5CY81_CRYPV
          Length = 653

 Score =  185 bits (470), Expect = 1e-45
 Identities = 95/175 (54%), Positives = 123/175 (70%), Gaps = 4/175 (2%)
 Frame = +3

Query: 6   NAPIPECP--VPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP+P+ P  + GH W  I H++ VTWLA ++DSI   +KY++LSA S FKGMSD+ K+E
Sbjct: 228 DAPVPKVPNSMKGHAWKDIFHDNTVTWLAYYRDSINNQFKYIFLSASSGFKGMSDYNKYE 287

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
           KAR+LK  I +IR +YRK   +     RQ  TA YLID LALRVG EK  ++EADTVGCC
Sbjct: 288 KARKLKDHIDAIRDDYRKKMTSGDITQRQLGTATYLIDFLALRVGGEKDTDEEADTVGCC 347

Query: 357 SLRVEHLKFT-PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           SLRVEH+ F     +++ DFLGKDSIRY N V +D + F NL +FCRNK   +N+
Sbjct: 348 SLRVEHITFNQQEKSITLDFLGKDSIRYYNTVVIDPSAFNNLTIFCRNKDKMENV 402

[81][TOP]
>UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4XZS7_CLAL4
          Length = 764

 Score =  185 bits (470), Expect = 1e-45
 Identities = 96/171 (56%), Positives = 118/171 (69%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIP  P  GH WG+I H+  V WLA WK++I+  +KYV L+A S+ KG+SD  KFE AR
Sbjct: 318 APIPPAP-EGHKWGEIRHDKSVVWLAMWKENISDSFKYVKLAANSSIKGISDMKKFETAR 376

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK  I  IR +Y+K       + RQ +TA YLID  ALR G EK EDEADTVGCCSLR 
Sbjct: 377 RLKDHIERIRDDYKKMLKDPFMQNRQIATATYLIDVFALRAGGEKGEDEADTVGCCSLRY 436

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
           EH+   PP TV FDFLGKDSIR+   VEVD+ VF NL++F +  KQP D++
Sbjct: 437 EHVTLRPPNTVIFDFLGKDSIRFYQEVEVDRQVFKNLRIFKKEPKQPGDDL 487

[82][TOP]
>UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio
           rerio RepID=UPI0001760D92
          Length = 748

 Score =  184 bits (468), Expect = 2e-45
 Identities = 93/173 (53%), Positives = 115/173 (66%), Gaps = 6/173 (3%)
 Frame = +3

Query: 18  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLK 197
           P+ P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK
Sbjct: 376 PKAP-PGTRWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLK 434

Query: 198 SCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEH 374
            C+  IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH
Sbjct: 435 KCVERIRAQYREDWRSKEMRIRQRAVALYFIDKLALRAGNEKDEGETADTVGCCSLRVEH 494

Query: 375 LKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           +K  P        V FDFLGKDSIRY N + V+K VF NLQLF  NKQ  D++
Sbjct: 495 IKLHPQLDGQDYVVEFDFLGKDSIRYYNKIPVEKRVFKNLQLFLENKQSEDDL 547

[83][TOP]
>UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group
            RepID=Q84ZL5_ORYSJ
          Length = 916

 Score =  184 bits (468), Expect = 2e-45
 Identities = 89/171 (52%), Positives = 121/171 (70%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG-GYKYVWLSAGSAFKGMSDHAKFEKA 185
            APIPECP+PG +W ++ H++ VTWLA W D I+   +KYV+L+A SA KG SD  K+EK+
Sbjct: 543  APIPECPIPGESWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYEKS 602

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+LK  +  IR  Y K + +K K  +Q + A YLIDKLALR GNEK EDEA+TVGCC+L+
Sbjct: 603  RKLKHHVHKIRDTYTKDFRSKDKTKKQIAVATYLIDKLALRAGNEKDEDEAETVGCCTLK 662

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            V+++   PP  + FDFLGKDSIRY N VEV+  V+  ++ F   K+P  ++
Sbjct: 663  VDNVTCVPPNKLQFDFLGKDSIRYFNTVEVELLVYKAIEEFRAGKKPGQDL 713

[84][TOP]
>UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR
          Length = 877

 Score =  184 bits (468), Expect = 2e-45
 Identities = 92/172 (53%), Positives = 122/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 503  DAPIPECPIPGERWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEK 562

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
            AR+LK  I +IR  Y K +A+K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L
Sbjct: 563  ARKLKDYIHNIRAAYTKDFASKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 622

Query: 363  RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            +V +++  PP  + FDFLGKDSIRYEN VEV+  V+  +  F   K+ +D++
Sbjct: 623  KVANVECIPPNKLKFDFLGKDSIRYENTVEVELPVYKAIGHFQVAKKQTDDL 674

[85][TOP]
>UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group
            RepID=A2YRB7_ORYSI
          Length = 916

 Score =  184 bits (468), Expect = 2e-45
 Identities = 89/171 (52%), Positives = 121/171 (70%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG-GYKYVWLSAGSAFKGMSDHAKFEKA 185
            APIPECP+PG +W ++ H++ VTWLA W D I+   +KYV+L+A SA KG SD  K+EK+
Sbjct: 543  APIPECPIPGESWKEVKHDNTVTWLAFWNDPISQKDFKYVFLAASSALKGQSDKEKYEKS 602

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+LK  +  IR  Y K + +K K  +Q + A YLIDKLALR GNEK EDEA+TVGCC+L+
Sbjct: 603  RKLKHHVHKIRDTYTKDFRSKDKTKKQIAVATYLIDKLALRAGNEKDEDEAETVGCCTLK 662

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            V+++   PP  + FDFLGKDSIRY N VEV+  V+  ++ F   K+P  ++
Sbjct: 663  VDNVTCVPPNKLQFDFLGKDSIRYFNTVEVELLVYKAIEEFRAGKKPGQDL 713

[86][TOP]
>UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum
           RepID=Q9Y180_LEIIN
          Length = 635

 Score =  184 bits (468), Expect = 2e-45
 Identities = 93/168 (55%), Positives = 112/168 (66%), Gaps = 2/168 (1%)
 Frame = +3

Query: 21  ECPVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           E PVP  GH W  + H+  VTWLA W+DS+ G  KYV L+  S+ KG SD  KFEKAR+L
Sbjct: 217 EVPVPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKL 276

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           K  +  IR  Y + + +    V QR+ A+Y ID+LALRVGNEK EDEADTVGCCSLRVEH
Sbjct: 277 KDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEH 336

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           ++  P   V FDFLGKDSIRY+N V V   V+  LQ F R K P  +I
Sbjct: 337 IQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDI 384

[87][TOP]
>UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN
          Length = 635

 Score =  184 bits (468), Expect = 2e-45
 Identities = 93/168 (55%), Positives = 112/168 (66%), Gaps = 2/168 (1%)
 Frame = +3

Query: 21  ECPVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           E PVP  GH W  + H+  VTWLA W+DS+ G  KYV L+  S+ KG SD  KFEKAR+L
Sbjct: 217 EVPVPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKL 276

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           K  +  IR  Y + + +    V QR+ A+Y ID+LALRVGNEK EDEADTVGCCSLRVEH
Sbjct: 277 KDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEH 336

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           ++  P   V FDFLGKDSIRY+N V V   V+  LQ F R K P  +I
Sbjct: 337 IQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDI 384

[88][TOP]
>UniRef100_A7SLG4 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SLG4_NEMVE
          Length = 502

 Score =  184 bits (468), Expect = 2e-45
 Identities = 91/176 (51%), Positives = 116/176 (65%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P+ P  GH W K+I +  VTWLA W ++I G YKYV L+  S  KG  D  K+E A
Sbjct: 127 DAKVPDPPA-GHKWKKVICDDTVTWLACWIENIQGSYKYVMLNPTSRLKGEKDWRKYETA 185

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK C+  IR++YRK W +K   +RQR  ALY IDKLALR G+EK +D ADTVGCCSLR
Sbjct: 186 RKLKECVDKIREDYRKDWKSKEMRLRQRGVALYFIDKLALRAGHEKDDDTADTVGCCSLR 245

Query: 366 VEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           VEH+K           V FDFLGKDS+RY N V ++K  F N++LF   KQ  D++
Sbjct: 246 VEHIKLHEEWEDKECVVEFDFLGKDSVRYRNFVPIEKRAFKNMKLFMEGKQEGDDL 301

[89][TOP]
>UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE
          Length = 758

 Score =  184 bits (467), Expect = 3e-45
 Identities = 92/170 (54%), Positives = 113/170 (66%), Gaps = 6/170 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 388 PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 447

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR +YR  W +K  ++RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEHL  
Sbjct: 448 DRIRSQYRDDWKSKEMKIRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHLTL 507

Query: 384 TPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            P        V FDFLGKDSIRY N V V+K VF NLQLF  +K+P D++
Sbjct: 508 HPEMDGQEFVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMEDKEPEDDL 557

[90][TOP]
>UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum bicolor
            RepID=C5YGY1_SORBI
          Length = 921

 Score =  184 bits (467), Expect = 3e-45
 Identities = 89/171 (52%), Positives = 121/171 (70%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG-GYKYVWLSAGSAFKGMSDHAKFEKA 185
            AP+PECP+PG +W +I H++ VTWLA W D I+   +KYV+L+A S+ KG SD  K+EK+
Sbjct: 548  APVPECPIPGESWKEIKHDNTVTWLAFWNDPISQKDFKYVFLAASSSLKGQSDKEKYEKS 607

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+LK  I  IR+ Y K +  K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 608  RKLKGHIQRIRENYTKDFKNKDVTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 667

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            V+++   PP  + FDFLGKDSIRY N VEV++ V+  ++ F   K+P + +
Sbjct: 668  VDNVTCMPPNKIQFDFLGKDSIRYFNTVEVEELVYKAIEGFRAGKKPGEGL 718

[91][TOP]
>UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1
           Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH
          Length = 713

 Score =  184 bits (467), Expect = 3e-45
 Identities = 93/190 (48%), Positives = 125/190 (65%), Gaps = 19/190 (10%)
 Frame = +3

Query: 6   NAPIPECPVP------------------GHNWGKIIHNSCVTWLAGWKD-SITGGYKYVW 128
           +AP+P+C VP                  GH W +I+H   VTWLA +KD S+   +KY++
Sbjct: 304 DAPVPKCSVPDCIHICRQIFNEFPKKQLGHGWSEIVHKQDVTWLASYKDDSVKKQHKYIF 363

Query: 129 LSAGSAFKGMSDHAKFEKARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALR 308
           LSA S  K  +D  K+EKAR+LK+ I  IR+ Y +   +     RQ  TA YLIDKLALR
Sbjct: 364 LSAESKLKAENDKKKYEKARRLKNLIGQIRENYERKLRSSDPVDRQLGTATYLIDKLALR 423

Query: 309 VGNEKAEDEADTVGCCSLRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           VGNEK+E+EADTVGCCSLRVEH++    T + FDFLGKDS+RY+N V+V + V+ N+Q F
Sbjct: 424 VGNEKSEEEADTVGCCSLRVEHIQVIEDTQIGFDFLGKDSMRYQNTVKVTEIVWKNMQSF 483

Query: 489 CRNKQPSDNI 518
            +NK+P D++
Sbjct: 484 IKNKKPGDDL 493

[92][TOP]
>UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO
          Length = 1043

 Score =  184 bits (467), Expect = 3e-45
 Identities = 92/176 (52%), Positives = 116/176 (65%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            N+ +P+ P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E A
Sbjct: 669  NSKVPQ-PPPGERWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYETA 727

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+L   I  IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLR
Sbjct: 728  RRLDKFIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLR 787

Query: 366  VEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VEH++           V FDF GKDSIRY N VEV+K VF NL+LF  NK+  D++
Sbjct: 788  VEHVQLHKELNNKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKDGDDL 843

[93][TOP]
>UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59XR0_CANAL
          Length = 780

 Score =  184 bits (467), Expect = 3e-45
 Identities = 95/172 (55%), Positives = 121/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE A
Sbjct: 333 DAKIPEPPA-GHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETA 391

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+L+  + SIRK+Y K   ++  + RQ +TA+YLID  ALR G EK EDEADTVGCCSLR
Sbjct: 392 RKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLR 451

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F ++ KQP D++
Sbjct: 452 YEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDL 503

[94][TOP]
>UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59WV6_CANAL
          Length = 780

 Score =  184 bits (467), Expect = 3e-45
 Identities = 95/172 (55%), Positives = 121/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE A
Sbjct: 333 DAKIPEPPA-GHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETA 391

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+L+  + SIRK+Y K   ++  + RQ +TA+YLID  ALR G EK EDEADTVGCCSLR
Sbjct: 392 RKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLR 451

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F ++ KQP D++
Sbjct: 452 YEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDL 503

[95][TOP]
>UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis
           RepID=Q1DXZ1_COCIM
          Length = 905

 Score =  184 bits (467), Expect = 3e-45
 Identities = 91/154 (59%), Positives = 110/154 (71%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KFEKAR+LK  I
Sbjct: 462 PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDFKKFEKARELKKHI 521

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+YRKG   +    RQR+TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 522 DRIRKDYRKGLKDELMANRQRATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 581

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 582 PPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 615

[96][TOP]
>UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735
           delta SOWgp RepID=C5P0Y8_COCP7
          Length = 905

 Score =  184 bits (467), Expect = 3e-45
 Identities = 91/154 (59%), Positives = 110/154 (71%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KFEKAR+LK  I
Sbjct: 462 PPAGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDIKGQSDFKKFEKARELKKHI 521

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+YRKG   +    RQR+TA+YLID+ ALR GNEK EDEADTVGCCSL+ EH+   
Sbjct: 522 DRIRKDYRKGLKDELMANRQRATAVYLIDQFALRAGNEKGEDEADTVGCCSLKYEHVTLK 581

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 582 PPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 615

[97][TOP]
>UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T3W2_PHYPA
          Length = 632

 Score =  184 bits (466), Expect = 4e-45
 Identities = 90/172 (52%), Positives = 119/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
           +A +PECP+PG  W +I H++ VTWLA WKD I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 259 DAAVPECPIPGQRWKEIRHDNTVTWLAYWKDPINDKEFKYVFLAASSSLKGQSDMQKYEK 318

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR LK  I  IR+ Y   +++     +Q + A YLID+LALR GNEK EDEADTVGCCSL
Sbjct: 319 ARMLKDYIDDIRRTYTHDFSSSDPTKQQIAVATYLIDRLALRAGNEKDEDEADTVGCCSL 378

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           +VEH+    P ++ FDFLGKDSIRY N VEVD+ V+  +  F + K+  D++
Sbjct: 379 KVEHVTLVAPKSLQFDFLGKDSIRYFNTVEVDERVYKAIGQFKKGKKEGDDL 430

[98][TOP]
>UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia
            vitripennis RepID=UPI00015B4D8F
          Length = 1019

 Score =  183 bits (465), Expect = 5e-45
 Identities = 93/169 (55%), Positives = 110/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PGH W +I H+  VTWLA W ++I G  KYV L+  S  KG  D  K+E AR+L   +
Sbjct: 651  PPPGHKWKEIRHDPTVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYETARKLAKSV 710

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL--- 377
              IR  YR+ W +K   +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+   
Sbjct: 711  DKIRATYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIALH 770

Query: 378  --KFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
              K      V FDFLGKDSIRY N V V+K VF +LQLF  NK P D +
Sbjct: 771  EKKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKSLQLFMENKSPGDEL 819

[99][TOP]
>UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36
           RepID=B9WIH6_CANDC
          Length = 777

 Score =  183 bits (465), Expect = 5e-45
 Identities = 94/172 (54%), Positives = 121/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE A
Sbjct: 330 DAKIPEPPA-GHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETA 388

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+L++ +  IRK+Y K   ++  + RQ +TA+YLID  ALR G EK EDEADTVGCCSLR
Sbjct: 389 RKLRNYVDDIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLR 448

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F ++ KQP D++
Sbjct: 449 YEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDL 500

[100][TOP]
>UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500
           RepID=B8MH68_TALSN
          Length = 864

 Score =  183 bits (465), Expect = 5e-45
 Identities = 89/154 (57%), Positives = 112/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W++++ G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 421 PPEGHKWKEVRHDQEGTWLAMWQENVNGNYKYVMLAANSDIKGQSDYKKFEKARELKKHI 480

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IR++YR G  ++    RQR+TA+YLIDK ALR GNEK EDEADTVGCCSL+ E++   
Sbjct: 481 DRIREDYRVGLKSELMADRQRATAVYLIDKFALRAGNEKGEDEADTVGCCSLKYENVSLR 540

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP TV FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 541 PPNTVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 574

[101][TOP]
>UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE
          Length = 904

 Score =  183 bits (464), Expect = 7e-45
 Identities = 88/171 (51%), Positives = 120/171 (70%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG-GYKYVWLSAGSAFKGMSDHAKFEKA 185
            AP+PECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK+
Sbjct: 531  APVPECPIPGESWKEVKHDNTVTWLAFWNDPINPKDFKYVFLAASSSLKGQSDKEKYEKS 590

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+LK  I  IR+ Y K +  K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 591  RKLKGHIQRIRENYTKDFKNKDVTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 650

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            V+++   PP  + FDFLGKDSIRY N VEV++ V+  ++ F   K+P  ++
Sbjct: 651  VDNVTCMPPNQIQFDFLGKDSIRYFNTVEVEELVYKAIEGFRAGKKPGQDL 701

[102][TOP]
>UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B7ZWU7_MAIZE
          Length = 574

 Score =  183 bits (464), Expect = 7e-45
 Identities = 88/171 (51%), Positives = 120/171 (70%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITG-GYKYVWLSAGSAFKGMSDHAKFEKA 185
           AP+PECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK+
Sbjct: 201 APVPECPIPGESWKEVKHDNTVTWLAFWNDPINPKDFKYVFLAASSSLKGQSDKEKYEKS 260

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IR+ Y K +  K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 261 RKLKGHIQRIRENYTKDFKNKDVTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 320

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           V+++   PP  + FDFLGKDSIRY N VEV++ V+  ++ F   K+P  ++
Sbjct: 321 VDNVTCMPPNQIQFDFLGKDSIRYFNTVEVEELVYKAIEGFRAGKKPGQDL 371

[103][TOP]
>UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence
           n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI
          Length = 857

 Score =  183 bits (464), Expect = 7e-45
 Identities = 91/172 (52%), Positives = 121/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
           N+ IPECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 484 NSQIPECPIPGESWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEK 543

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR+LK+ I  IR  Y K + +K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L
Sbjct: 544 ARKLKNYIKDIRATYTKDFVSKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 603

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           +VE++   PP ++ FDFLGKDSIRYE  VEV+  V+  ++ F   K  SD++
Sbjct: 604 KVENVIPEPPNSLQFDFLGKDSIRYEKTVEVELPVYKAIEQFRVGKSGSDDL 655

[104][TOP]
>UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR
          Length = 664

 Score =  182 bits (463), Expect = 9e-45
 Identities = 92/170 (54%), Positives = 117/170 (68%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           +PIP+ P  GH W +++H   VTWLA W+DSI G +KYV L+  SA KG SD  KFEKAR
Sbjct: 219 SPIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILGSFKYVMLAPSSAIKGQSDMLKFEKAR 277

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK+ +  IR+ Y + + ++     QR+ A+Y IDKLALRVGNEK  DEADTVGCCSLRV
Sbjct: 278 ELKNHVDEIRRCYIEDFESRELMKAQRAVAMYFIDKLALRVGNEKGSDEADTVGCCSLRV 337

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           EH++  P   V FDFLGKDSIRYEN   V   V+  L+ F + K+  D+I
Sbjct: 338 EHIELKPDYVVKFDFLGKDSIRYENEAVVLPRVYELLRRFTKGKKTGDDI 387

[105][TOP]
>UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma
           cruzi RepID=Q4DTW1_TRYCR
          Length = 664

 Score =  182 bits (463), Expect = 9e-45
 Identities = 92/170 (54%), Positives = 117/170 (68%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           +PIP+ P  GH W +++H   VTWLA W+DSI G +KYV L+  SA KG SD  KFEKAR
Sbjct: 219 SPIPK-PPEGHRWKEVLHEHNVTWLAMWRDSILGSFKYVMLAPSSAIKGQSDMLKFEKAR 277

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK+ +  IR+ Y + + ++     QR+ A+Y IDKLALRVGNEK  DEADTVGCCSLRV
Sbjct: 278 ELKNHVDEIRRCYIEDFESRELMKAQRAVAMYFIDKLALRVGNEKGSDEADTVGCCSLRV 337

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           EH++  P   V FDFLGKDSIRYEN   V   V+  L+ F + K+  D+I
Sbjct: 338 EHIELKPDHVVKFDFLGKDSIRYENEAVVLPRVYELLRRFTKGKKTGDDI 387

[106][TOP]
>UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra
           magnipapillata RepID=UPI000192545C
          Length = 726

 Score =  182 bits (462), Expect = 1e-44
 Identities = 92/176 (52%), Positives = 118/176 (67%), Gaps = 6/176 (3%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A +P+ P  G  W  + H++ V+WLA W ++I GGYKYV L+A +  KG  D  K+E AR
Sbjct: 339 AKVPQ-PPEGQKWKAVQHDNTVSWLACWVENIAGGYKYVMLNAATRLKGEKDWQKYETAR 397

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLR 365
           +LK C+ +IR+ Y   W +K  ++RQR  A+Y IDKLALR G+EK E E ADTVGCCSLR
Sbjct: 398 KLKECVETIRENYINDWKSKEMKIRQRGVAMYFIDKLALRAGHEKEEGESADTVGCCSLR 457

Query: 366 VEHLKFTP-----PTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           VEH+   P        V FDFLGKDSIRY N+V V+K VF NLQLF + KQ  D++
Sbjct: 458 VEHITLHPEKDGQENVVEFDFLGKDSIRYTNSVPVEKRVFKNLQLFMQGKQAGDDL 513

[107][TOP]
>UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI
          Length = 997

 Score =  182 bits (462), Expect = 1e-44
 Identities = 92/176 (52%), Positives = 115/176 (65%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            N+ +P  P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E A
Sbjct: 623  NSKVPT-PPPGQRWKEVRHDNTVTWLASWVENVQGQVKYIMLNPSSKLKGEKDHIKYETA 681

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+L   I  IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLR
Sbjct: 682  RRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLR 741

Query: 366  VEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VEH++           V FDF GKDSIRY N VEV+K VF NL+LF  NK+  D++
Sbjct: 742  VEHVQLHRELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKEGDDL 797

[108][TOP]
>UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum
           RepID=Q0UUB0_PHANO
          Length = 887

 Score =  182 bits (462), Expect = 1e-44
 Identities = 92/167 (55%), Positives = 118/167 (70%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           NA +P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KFEKA
Sbjct: 438 NAKVPPPPA-GHRWKEVKHDHEGTWLAMWQENINGAYKYVMLAANSDIKGQSDFKKFEKA 496

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IR++YR+   ++    RQR+TA+YLID+ ALR GNEK EDEADTVGCCSL+
Sbjct: 497 RELKKHIDRIRQDYRRELKSEKMVDRQRATAIYLIDQFALRAGNEKGEDEADTVGCCSLK 556

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQP 506
            +H+   PP TV FDFLGKDSIR+ + V+VD  VF NL++F   K+P
Sbjct: 557 FQHITLRPPETVIFDFLGKDSIRFYDEVKVDAQVFKNLKIF--KKEP 601

[109][TOP]
>UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL
          Length = 778

 Score =  182 bits (461), Expect = 2e-44
 Identities = 94/172 (54%), Positives = 120/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A IPE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE A
Sbjct: 331 DAKIPEPPA-GHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETA 389

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+L+  + SIRK+Y K   ++  + RQ +TA+YLID  ALR G EK EDEADTVGCCSLR
Sbjct: 390 RKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLR 449

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            EH+   PP  V FD LGKDSIR+   VEVDK VF NL++F ++ KQP D++
Sbjct: 450 YEHVTLKPPNKVIFDLLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDL 501

[110][TOP]
>UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR
          Length = 881

 Score =  181 bits (460), Expect = 2e-44
 Identities = 92/172 (53%), Positives = 121/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKA
Sbjct: 432 DAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKA 490

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+
Sbjct: 491 RELKKHIDKIRKDYKKNMKNELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLK 550

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            E++   PP  V FDFLGKDSIR+ + VEVD  VF NL++F ++ K+  D I
Sbjct: 551 YENVTLKPPNKVVFDFLGKDSIRFYDEVEVDAQVFKNLKIFKKSPKKEGDEI 602

[111][TOP]
>UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357
           RepID=B8MY66_ASPFN
          Length = 881

 Score =  181 bits (460), Expect = 2e-44
 Identities = 92/172 (53%), Positives = 121/172 (70%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKA
Sbjct: 432 DAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKA 490

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+
Sbjct: 491 RELKKHIDKIRKDYKKNMKNELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLK 550

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
            E++   PP  V FDFLGKDSIR+ + VEVD  VF NL++F ++ K+  D I
Sbjct: 551 YENVTLKPPNKVVFDFLGKDSIRFYDEVEVDAQVFKNLKIFKKSPKKEGDEI 602

[112][TOP]
>UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
            RepID=UPI000198447D
          Length = 883

 Score =  181 bits (459), Expect = 3e-44
 Identities = 90/171 (52%), Positives = 115/171 (67%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
            AP+PECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EKA
Sbjct: 510  APVPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKA 569

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R LK  I +IR  Y K +  K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 570  RLLKDYIQNIRATYTKDFTNKDTMKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 629

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VE++   PP  + FDFLGKDSIRY N VEV+  V+  +  F   K   D++
Sbjct: 630  VENVALVPPNKLEFDFLGKDSIRYFNTVEVELPVYKAIGQFKTGKSGGDDL 680

[113][TOP]
>UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7PX10_VITVI
          Length = 789

 Score =  181 bits (459), Expect = 3e-44
 Identities = 90/171 (52%), Positives = 115/171 (67%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
           AP+PECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EKA
Sbjct: 416 APVPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKA 475

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R LK  I +IR  Y K +  K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 476 RLLKDYIQNIRATYTKDFTNKDTMKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 535

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           VE++   PP  + FDFLGKDSIRY N VEV+  V+  +  F   K   D++
Sbjct: 536 VENVALVPPNKLEFDFLGKDSIRYFNTVEVELPVYKAIGQFKTGKSGGDDL 586

[114][TOP]
>UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI
          Length = 1045

 Score =  181 bits (459), Expect = 3e-44
 Identities = 90/169 (53%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 677  PPPGERWKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKFI 736

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 737  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 796

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  NK+  D++
Sbjct: 797  KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKDGDDL 845

[115][TOP]
>UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA
          Length = 829

 Score =  181 bits (459), Expect = 3e-44
 Identities = 93/177 (52%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IP  P  GH W ++ H+  VTWL  W ++I G  KY+ L+  S  KG  D  K+E A
Sbjct: 445 DSKIPVAPA-GHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETA 503

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK C+  IR  Y++ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 504 RRLKMCVEKIRNTYKEDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 563

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+            V FDF GKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 564 RVEHINLFQELDGQEFVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPDDDL 620

[116][TOP]
>UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis
           thaliana RepID=Q8RX06_ARATH
          Length = 514

 Score =  181 bits (458), Expect = 3e-44
 Identities = 89/171 (52%), Positives = 118/171 (69%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
           APIPECP+ G  W ++ H++ VTWLA W D I    +KYV+L AGS+ KG+SD  K+EKA
Sbjct: 138 APIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYEKA 197

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R L   I +IR  Y K + AK  ++RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 198 RNLTDHIDNIRTTYTKNFTAKDVKMRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 257

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           V +++  PP  + FDFLGKDSI+Y N VEV+  V+  +  F   K  +D++
Sbjct: 258 VGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDL 308

[117][TOP]
>UniRef100_Q56XA9 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana
           RepID=Q56XA9_ARATH
          Length = 396

 Score =  181 bits (458), Expect = 3e-44
 Identities = 89/171 (52%), Positives = 118/171 (69%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
           APIPECP+ G  W ++ H++ VTWLA W D I    +KYV+L AGS+ KG+SD  K+EKA
Sbjct: 20  APIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYEKA 79

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R L   I +IR  Y K + AK  ++RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 80  RNLTDHIDNIRTTYTKNFTAKDVKMRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 139

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           V +++  PP  + FDFLGKDSI+Y N VEV+  V+  +  F   K  +D++
Sbjct: 140 VGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDL 190

[118][TOP]
>UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major
           RepID=Q4Q2K0_LEIMA
          Length = 634

 Score =  181 bits (458), Expect = 3e-44
 Identities = 91/168 (54%), Positives = 111/168 (66%), Gaps = 2/168 (1%)
 Frame = +3

Query: 21  ECPVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           E PVP  GH W  + H+  VTWLA W+D++ G  KYV L+  S+ KG SD  KFEKAR+L
Sbjct: 217 EVPVPPAGHKWAAVQHDHTVTWLAMWRDNVAGNMKYVMLAPSSSVKGQSDMVKFEKARKL 276

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           K  +  IR  Y + + +    V QR+ A+Y ID+LALRVGNEK EDEADTVGCCSLRVEH
Sbjct: 277 KDKVDDIRASYMEAFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEH 336

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           ++  P   V FDFLGKDSIRY+N V V   V+  LQ F   K P  +I
Sbjct: 337 IQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTCRKSPGMDI 384

[119][TOP]
>UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH
          Length = 916

 Score =  181 bits (458), Expect = 3e-44
 Identities = 89/171 (52%), Positives = 118/171 (69%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
            APIPECP+ G  W ++ H++ VTWLA W D I    +KYV+L AGS+ KG+SD  K+EKA
Sbjct: 540  APIPECPIAGERWKEVKHDNTVTWLAFWADPINPKEFKYVFLGAGSSLKGLSDKEKYEKA 599

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R L   I +IR  Y K + AK  ++RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 600  RNLTDHIDNIRTTYTKNFTAKDVKMRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 659

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            V +++  PP  + FDFLGKDSI+Y N VEV+  V+  +  F   K  +D++
Sbjct: 660  VGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDL 710

[120][TOP]
>UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA
          Length = 785

 Score =  180 bits (457), Expect = 4e-44
 Identities = 91/162 (56%), Positives = 110/162 (67%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIPE P  GH WG+I H++ V WL+ W+++I+  +KYV  +A S  KGMSD  KFEKAR
Sbjct: 338 APIPE-PPKGHKWGEIRHDNTVQWLSMWRENISNSFKYVRFAANSTLKGMSDFKKFEKAR 396

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
            LK  I  +R +Y+    +     RQ + A YLID  ALR G EKA+DEADTVGCCSLR 
Sbjct: 397 MLKDHIDKVRTDYKSKMKSPKTLDRQMAVATYLIDVFALRAGGEKADDEADTVGCCSLRY 456

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
           EH+   PP TV FDFLGKDSIRY   VEVD  VF NL++F R
Sbjct: 457 EHVTLRPPNTVVFDFLGKDSIRYYQEVEVDAQVFKNLKIFKR 498

[121][TOP]
>UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404
           RepID=C5M985_CANTT
          Length = 777

 Score =  180 bits (457), Expect = 4e-44
 Identities = 92/172 (53%), Positives = 120/172 (69%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +PE P  GH WG+I H++ VTWLA WK++I+   KYV  +  S+ KG SD  KFE A
Sbjct: 330 DAKVPEPPA-GHQWGEIRHDNEVTWLAMWKENISDSTKYVRFANNSSIKGQSDFKKFETA 388

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+L++ +  IRK+Y K   ++  + RQ +TA+YLID  ALR G EK +DEADTVGCCSLR
Sbjct: 389 RRLRNHVDEIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGDDEADTVGCCSLR 448

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F +  KQP D++
Sbjct: 449 YEHVTLKPPNKVVFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKAPKQPGDDL 500

[122][TOP]
>UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin
           54-1255 RepID=B6H1W4_PENCW
          Length = 864

 Score =  180 bits (457), Expect = 4e-44
 Identities = 92/170 (54%), Positives = 117/170 (68%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KFEKA
Sbjct: 414 DAKVPP-PPPGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDFKKFEKA 472

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K         RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+
Sbjct: 473 RELKKHIEKIRKDYQKNLKHDMMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLK 532

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDN 515
            E++   PP TV FDFLGKDSIR+ + V+VD  VF NL++F   K P  N
Sbjct: 533 YENVTLKPPNTVVFDFLGKDSIRFYDEVQVDLQVFKNLKIF--KKAPKKN 580

[123][TOP]
>UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio
           RepID=Q6T721_DANRE
          Length = 600

 Score =  180 bits (456), Expect = 6e-44
 Identities = 89/176 (50%), Positives = 117/176 (66%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++ H++ VTWLA W ++I    KY+ L+  S  KG  D  K+E A
Sbjct: 225 DSKIPEPPA-GHKWKRVQHDNTVTWLASWLENIPKRPKYIMLNPSSKLKGEKDWQKYETA 283

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK C+ SIRK Y + W ++  + RQR  A+Y IDKLALR GNEK ++ ADTVGCCSLR
Sbjct: 284 RRLKECVKSIRKRYMQDWKSREMKSRQRGVAIYFIDKLALRAGNEKDDESADTVGCCSLR 343

Query: 366 VEHLKFTP-----PTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           VEH++           V FDFLGKDSIRY N V V+K VF NL+LF ++K P D++
Sbjct: 344 VEHIRLHKHLDGLDHVVEFDFLGKDSIRYYNKVPVEKQVFKNLKLFIKHKDPEDDL 399

[124][TOP]
>UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani
            RepID=Q9NJG8_LEIDO
          Length = 949

 Score =  180 bits (456), Expect = 6e-44
 Identities = 93/168 (55%), Positives = 112/168 (66%), Gaps = 2/168 (1%)
 Frame = +3

Query: 21   ECPVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
            E PVP  GH W  + H+  VTWLA W+DS+ G  KYV L+  S+ KG SD  KFEKAR+L
Sbjct: 532  EVPVPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKL 591

Query: 195  KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
            K  +  IR  Y + + +    V QR+ A+Y ID+LALRVGNEK EDEADTVGCCSLRVEH
Sbjct: 592  KDKVDDIRASYMEDFKSNDLHVAQRAVAMY-IDRLALRVGNEKGEDEADTVGCCSLRVEH 650

Query: 375  LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            ++  P   V FDFLGKDSIRY+N V V   V+  LQ F R K P  +I
Sbjct: 651  IQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDI 698

[125][TOP]
>UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC
          Length = 998

 Score =  180 bits (456), Expect = 6e-44
 Identities = 89/161 (55%), Positives = 116/161 (72%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KFEKA
Sbjct: 549  DAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGLSDYKKFEKA 607

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+
Sbjct: 608  RELKKHIDRIRKDYQKALKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLK 667

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
             E++   PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 668  YENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 708

[126][TOP]
>UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1D4R5_NEOFI
          Length = 886

 Score =  180 bits (456), Expect = 6e-44
 Identities = 89/161 (55%), Positives = 116/161 (72%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG+SD+ KFEKA
Sbjct: 437 DAPVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGLSDYKKFEKA 495

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+
Sbjct: 496 RELKKHIDRIRKDYQKALKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLK 555

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            E++   PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 556 YENVTLKPPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 596

[127][TOP]
>UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia
           guttata RepID=UPI000194BDF0
          Length = 662

 Score =  179 bits (455), Expect = 8e-44
 Identities = 93/177 (52%), Positives = 119/177 (67%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  K+E A
Sbjct: 286 DSKIPE-PPEGHKWKEVRFDNTVTWLASWTENIQNTLKYIMLNPSSKLKGEKDWEKYEVA 344

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  + +IR +YRK W +K  + RQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 345 RRLKDVVHTIRAQYRKDWKSKEIKKRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 404

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKDSIRY N V V+K VF NLQLF +NK P++++
Sbjct: 405 RVEHIQLHPQLDGQEHVVEFDFLGKDSIRYYNKVSVEKPVFKNLQLFMKNKDPTEDL 461

[128][TOP]
>UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus
            RepID=B0WA62_CULQU
          Length = 962

 Score =  179 bits (455), Expect = 8e-44
 Identities = 91/172 (52%), Positives = 114/172 (66%), Gaps = 5/172 (2%)
 Frame = +3

Query: 18   PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLK 197
            P+ P  GH W ++ H++ V+WLA W +++ G  KYV L+  S  KG  D  K+E AR+L 
Sbjct: 595  PKAP-EGHRWKEVRHDNTVSWLASWTENVQGQVKYVMLNPSSKLKGEKDWQKYETARRLL 653

Query: 198  SCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL 377
              I  IR  YR  W +K   +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+
Sbjct: 654  KHIDKIRDTYRDEWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHI 713

Query: 378  KF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            +           V FDFLGKDSIRY N VEV+K VF NL+LF  NK+P D++
Sbjct: 714  ELHKELNGKENVVVFDFLGKDSIRYYNEVEVEKRVFKNLELFKENKKPGDDL 765

[129][TOP]
>UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA
           n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC
          Length = 884

 Score =  179 bits (455), Expect = 8e-44
 Identities = 89/161 (55%), Positives = 115/161 (71%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKA
Sbjct: 435 DAPVPP-PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKA 493

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+
Sbjct: 494 RELKHHIGRIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLK 553

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            E++   PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 554 YENVTLKPPNKVVFDFLGKDSIRFYDEVEVDAQVFKNLKIF 594

[130][TOP]
>UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1
           Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294
          Length = 786

 Score =  179 bits (454), Expect = 1e-43
 Identities = 90/167 (53%), Positives = 109/167 (65%), Gaps = 6/167 (3%)
 Frame = +3

Query: 36  GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCIASI 215
           GH W ++ H+  VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+  I
Sbjct: 417 GHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKMCVEKI 476

Query: 216 RKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKFTPP 392
           R  Y++ W +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+     
Sbjct: 477 RNTYKEDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLFQE 536

Query: 393 T-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                  V FDF GKDSIRY N V V+K VF NLQLF  NKQP D++
Sbjct: 537 LDGQEFVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPDDDL 583

[131][TOP]
>UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus
           RepID=UPI0000ECD01B
          Length = 593

 Score =  179 bits (454), Expect = 1e-43
 Identities = 94/177 (53%), Positives = 116/177 (65%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE PV GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  KFE A
Sbjct: 217 DSKIPEPPV-GHKWKEVRFDNTVTWLASWTENIQNSLKYIMLNPSSKLKGEKDWQKFEVA 275

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +Y+  W +K  + RQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 276 RKLKDVVHKIRAQYQADWKSKEMKKRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 335

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+K           V FDFLGKDSIRY N V V+K VF NLQLF +NK P D++
Sbjct: 336 RVEHIKLHSKLDGQEHVVEFDFLGKDSIRYYNKVSVEKPVFKNLQLFMKNKDPGDDL 392

[132][TOP]
>UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus
           RepID=Q6T722_CHICK
          Length = 593

 Score =  179 bits (454), Expect = 1e-43
 Identities = 94/177 (53%), Positives = 116/177 (65%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE PV GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  KFE A
Sbjct: 217 DSKIPEPPV-GHKWKEVRFDNTVTWLASWTENIQNSLKYIMLNPSSKLKGEKDWQKFEVA 275

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +Y+  W +K  + RQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 276 RKLKDVVHKIRAQYQADWKSKEMKKRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 335

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH+K           V FDFLGKDSIRY N V V+K VF NLQLF +NK P D++
Sbjct: 336 RVEHIKLHSKLDGQEHVVEFDFLGKDSIRYYNKVSVEKPVFKNLQLFMKNKDPGDDL 392

[133][TOP]
>UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7EXF7_SCLS1
          Length = 911

 Score =  179 bits (454), Expect = 1e-43
 Identities = 95/170 (55%), Positives = 118/170 (69%), Gaps = 1/170 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A +P  P  GH W  I H++  TWLA W+++I G YKYV L+A S+ KG SD+ KFEKAR
Sbjct: 459 ATVPS-PPEGHKWKAIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDYKKFEKAR 517

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +LK  I  IRK+Y +   A+    RQR+TA+YLIDK ALR GNEK AE+EA+TVGCCSL+
Sbjct: 518 ELKEHIDRIRKDYTQDLHAELMADRQRATAVYLIDKFALRAGNEKDAENEAETVGCCSLK 577

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDN 515
            EH+   PP TV FDFLGKDSIR+ + V VD  VF NL++F   K P  N
Sbjct: 578 YEHVTLKPPNTVIFDFLGKDSIRFYDEVTVDPQVFKNLKIF--KKAPKKN 625

[134][TOP]
>UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL
          Length = 886

 Score =  179 bits (454), Expect = 1e-43
 Identities = 90/160 (56%), Positives = 113/160 (70%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           AP+P  P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD  KFEKAR
Sbjct: 438 APVPP-PPEGHRWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDFKKFEKAR 496

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK  I  IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEADTVGCCSL+ 
Sbjct: 497 ELKKHIDRIRKDYQKSLKHELMVERQKATAVYLIDQFALRAGNEKGEDEADTVGCCSLKY 556

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           E++   PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 557 ENVTLKPPNKVIFDFLGKDSIRFYDEVEVDAQVFKNLKIF 596

[135][TOP]
>UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE
          Length = 966

 Score =  179 bits (453), Expect = 1e-43
 Identities = 91/172 (52%), Positives = 113/172 (65%), Gaps = 5/172 (2%)
 Frame = +3

Query: 18   PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLK 197
            P+ P  GH W ++ H++ V+WLA W +++ G  KYV L+  S  KG  D  K+E AR+L 
Sbjct: 600  PKAP-EGHRWKEVRHDNSVSWLASWTENVQGQVKYVMLNPSSKLKGEKDWQKYETARRLL 658

Query: 198  SCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL 377
              I  IR  YR  W +K   +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+
Sbjct: 659  KHIDKIRDTYRDEWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHI 718

Query: 378  KF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                        V FDFLGKDSIRY N VEV+K VF NL+LF  NK+P D++
Sbjct: 719  DLHKELNGKENVVVFDFLGKDSIRYYNEVEVEKRVFKNLELFKENKKPGDDL 770

[136][TOP]
>UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura
            RepID=B5DMS2_DROPS
          Length = 1054

 Score =  179 bits (453), Expect = 1e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 686  PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKSI 745

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 746  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 805

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 806  KELNDKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 854

[137][TOP]
>UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE
          Length = 1042

 Score =  179 bits (453), Expect = 1e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 674  PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKSI 733

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 734  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 793

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 794  KELNDKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 842

[138][TOP]
>UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN
          Length = 990

 Score =  179 bits (453), Expect = 1e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 636  PPPGQRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 695

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 696  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 755

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 756  KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKDGDDL 804

[139][TOP]
>UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DEP3_LACTC
          Length = 756

 Score =  179 bits (453), Expect = 1e-43
 Identities = 91/160 (56%), Positives = 110/160 (68%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IP+ P  GH WG+I H+S V WLA W+++I+  +KYV  +A S+ KGMSD  KFEKAR
Sbjct: 309 AEIPKAP-EGHKWGEIRHDSTVQWLAMWRENISNSFKYVRFAANSSLKGMSDFKKFEKAR 367

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           QL+  I +IR +Y K   +K    RQ + A Y ID  ALR G EKA+DEADTVGCCSLR 
Sbjct: 368 QLRGFIDAIRADYTKNLKSKVMLERQIAVACYFIDVFALRAGGEKADDEADTVGCCSLRY 427

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           EH+   PP TV FDFLGKDSIR+   VEV K VF NL +F
Sbjct: 428 EHVTLKPPNTVIFDFLGKDSIRFYQEVEVTKQVFKNLTIF 467

[140][TOP]
>UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana
           B05.10 RepID=A6S3Q9_BOTFB
          Length = 912

 Score =  179 bits (453), Expect = 1e-43
 Identities = 95/171 (55%), Positives = 118/171 (69%), Gaps = 1/171 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P  GH W  I H++  TWLA W+++I G YKYV L+A S+ KG SD  KFEKA
Sbjct: 459 DATVPS-PPEGHKWKAIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDFKKFEKA 517

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
           R+LK  I  IRK+Y +   A+    RQR+TA+YLIDK ALR GNEK AE+EA+TVGCCSL
Sbjct: 518 RELKEHIDRIRKDYTQDLKAELMADRQRATAVYLIDKFALRAGNEKDAENEAETVGCCSL 577

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDN 515
           + EH+   PP TV FDFLGKDSIR+ + V VD  VF NL++F   K P  N
Sbjct: 578 KYEHVTLKPPNTVIFDFLGKDSIRFYDEVTVDPQVFKNLKIF--KKAPKKN 626

[141][TOP]
>UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster
           RepID=Q8IR39_DROME
          Length = 581

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 227 PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 286

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 287 DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 346

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                    V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 347 KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 395

[142][TOP]
>UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster
            RepID=Q494M1_DROME
          Length = 974

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 620  PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 679

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 680  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 739

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 740  KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 788

[143][TOP]
>UniRef100_Q1WWG8 IP16129p (Fragment) n=1 Tax=Drosophila melanogaster
           RepID=Q1WWG8_DROME
          Length = 382

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 133 PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 192

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 193 DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 252

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                    V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 253 KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 301

[144][TOP]
>UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME
          Length = 581

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 227 PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 286

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 287 DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 346

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                    V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 347 KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 395

[145][TOP]
>UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni
           RepID=C4Q6C8_SCHMA
          Length = 587

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 112/169 (66%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H++ VTWLA W ++I   +KY+ L+  S  KG  D  K+E AR L   I
Sbjct: 316 PPKGHKWKEVRHDNSVTWLACWTENIQNSFKYIMLNPSSRLKGEKDWKKYETARCLHKVI 375

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR +YR  +  K   +RQR+ ALY IDKLALR GNEK EDEADTVGCCSLR EH+K  
Sbjct: 376 DKIRADYRADFKHKEMRIRQRAVALYFIDKLALRAGNEKDEDEADTVGCCSLRYEHIKLH 435

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                 P  V FDFLGKDSIRY+NAV V K VF N++LF +NK+ +D++
Sbjct: 436 EELNGQPYVVEFDFLGKDSIRYQNAVSVPKRVFKNVKLFLKNKKENDDL 484

[146][TOP]
>UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni
           RepID=C4Q6C7_SCHMA
          Length = 652

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 112/169 (66%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H++ VTWLA W ++I   +KY+ L+  S  KG  D  K+E AR L   I
Sbjct: 316 PPKGHKWKEVRHDNSVTWLACWTENIQNSFKYIMLNPSSRLKGEKDWKKYETARCLHKVI 375

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR +YR  +  K   +RQR+ ALY IDKLALR GNEK EDEADTVGCCSLR EH+K  
Sbjct: 376 DKIRADYRADFKHKEMRIRQRAVALYFIDKLALRAGNEKDEDEADTVGCCSLRYEHIKLH 435

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                 P  V FDFLGKDSIRY+NAV V K VF N++LF +NK+ +D++
Sbjct: 436 EELNGQPYVVEFDFLGKDSIRYQNAVSVPKRVFKNVKLFLKNKKENDDL 484

[147][TOP]
>UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA
          Length = 580

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 226 PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 285

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 286 DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 345

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                    V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 346 KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKDGDDL 394

[148][TOP]
>UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR
          Length = 1063

 Score =  178 bits (452), Expect = 2e-43
 Identities = 90/173 (52%), Positives = 114/173 (65%), Gaps = 5/173 (2%)
 Frame = +3

Query: 15   IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
            +P+ P+ G  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L
Sbjct: 692  VPQPPMGGR-WKEVRHDNTVTWLASWTENVQGQVKYIMLNPSSKLKGEKDHIKYETARRL 750

Query: 195  KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
               I  IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH
Sbjct: 751  DKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEH 810

Query: 375  LKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            ++           V FDF GKDSIRY N VEV+K VF NL+LF  NK+  D++
Sbjct: 811  VQLHKELNCKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMENKKEGDDL 863

[149][TOP]
>UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE
          Length = 970

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 616  PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 675

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 676  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 735

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 736  KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 784

[150][TOP]
>UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER
          Length = 969

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 615  PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 674

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 675  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 734

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 735  KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKDGDDL 783

[151][TOP]
>UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster RepID=TOP1_DROME
          Length = 972

 Score =  178 bits (452), Expect = 2e-43
 Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ VTWLA W +++ G  KY+ L+  S  KG  DH K+E AR+L   I
Sbjct: 618  PPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVI 677

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 678  DKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLH 737

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDF GKDSIRY N VEV+K VF NL+LF  +K+  D++
Sbjct: 738  KELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDL 786

[152][TOP]
>UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A49
          Length = 692

 Score =  178 bits (451), Expect = 2e-43
 Identities = 93/172 (54%), Positives = 112/172 (65%), Gaps = 8/172 (4%)
 Frame = +3

Query: 27  PVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           PVP  GH W ++ H++ VTWL  W ++I G  KY+ L+A S  KG  D  K+E AR+LKS
Sbjct: 269 PVPPAGHRWKEVRHDNTVTWLVSWTENIQGSIKYIMLNANSKLKGEKDWEKYEVARKLKS 328

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHL 377
           C+ +IR +YR    ++    RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+
Sbjct: 329 CVDNIRSQYRSDLKSRQMSTRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHI 388

Query: 378 KFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                       V FDFLGKDSIRY N V V K VF NL+LF  NKQP D +
Sbjct: 389 TLHEQMDGKEYVVEFDFLGKDSIRYYNKVPVIKKVFKNLKLFLENKQPGDEL 440

[153][TOP]
>UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A48
          Length = 632

 Score =  178 bits (451), Expect = 2e-43
 Identities = 93/172 (54%), Positives = 112/172 (65%), Gaps = 8/172 (4%)
 Frame = +3

Query: 27  PVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           PVP  GH W ++ H++ VTWL  W ++I G  KY+ L+A S  KG  D  K+E AR+LKS
Sbjct: 259 PVPPAGHRWKEVRHDNTVTWLVSWTENIQGSIKYIMLNANSKLKGEKDWEKYEVARKLKS 318

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHL 377
           C+ +IR +YR    ++    RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+
Sbjct: 319 CVDNIRSQYRSDLKSRQMSTRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHI 378

Query: 378 KFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                       V FDFLGKDSIRY N V V K VF NL+LF  NKQP D +
Sbjct: 379 TLHEQMDGKEYVVEFDFLGKDSIRYYNKVPVIKKVFKNLKLFLENKQPGDEL 430

[154][TOP]
>UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH
          Length = 917

 Score =  178 bits (451), Expect = 2e-43
 Identities = 89/171 (52%), Positives = 117/171 (68%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
            APIPECP+PG  W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EKA
Sbjct: 538  APIPECPIPGERWKEVKHDNTVTWLAFWSDPINPKEFKYVFLAASSSLKGQSDKEKYEKA 597

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R+L + I SIR  Y K +  K    RQ + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 598  RKLHNHIGSIRAAYTKDFNNKDVTKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 657

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            V +++  PP  + FDFLGKDSI+Y N VEV+  V+  +  F   K  +D++
Sbjct: 658  VGNVECIPPNKLKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSKTDDL 708

[155][TOP]
>UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI
          Length = 871

 Score =  178 bits (451), Expect = 2e-43
 Identities = 87/154 (56%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 428 PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKARELKKHI 487

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
           A IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+ E++   
Sbjct: 488 ARIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLKYENVTLK 547

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 548 PPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 581

[156][TOP]
>UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI
          Length = 871

 Score =  178 bits (451), Expect = 2e-43
 Identities = 87/154 (56%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 428 PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKARELKKHI 487

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
           A IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+ E++   
Sbjct: 488 ARIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLKYENVTLK 547

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 548 PPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 581

[157][TOP]
>UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2
           Tax=Emericella nidulans RepID=C8VUK1_EMENI
          Length = 871

 Score =  178 bits (451), Expect = 2e-43
 Identities = 87/154 (56%), Positives = 111/154 (72%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 428 PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKARELKKHI 487

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
           A IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+ E++   
Sbjct: 488 ARIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLKYENVTLK 547

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + VEVD  VF NL++F
Sbjct: 548 PPNKVIFDFLGKDSIRFYDEVEVDPQVFKNLKIF 581

[158][TOP]
>UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum
           RepID=UPI0001792028
          Length = 1011

 Score =  177 bits (450), Expect = 3e-43
 Identities = 90/169 (53%), Positives = 111/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H+  VTWLA W +++ G  KYV L+  S  KG  D  K+E AR+L   I
Sbjct: 379 PPPGHKWKEVRHDFGVTWLASWIENVQGQVKYVMLNPSSKLKGEKDWQKYETARRLAKSI 438

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
             IR+ Y   W ++   VRQRS ALY IDKLALR GNEK ED+ADTVGCCSLRVEH++  
Sbjct: 439 DKIRENYINDWKSREMHVRQRSVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIQLH 498

Query: 384 ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                    V FDFLGKDSIRY N V V+K VF NL++F  NK+ SD++
Sbjct: 499 EEFNDKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLKIFMENKKGSDDL 547

[159][TOP]
>UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT
          Length = 927

 Score =  177 bits (450), Expect = 3e-43
 Identities = 91/173 (52%), Positives = 120/173 (69%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG  W ++ +++ VTWLA W D I    +KYV+L+A S  KG SD  K+EK
Sbjct: 552  DAPIPECPIPGERWKEVRNDNTVTWLAFWIDPINQKEFKYVFLAASSTLKGQSDKEKYEK 611

Query: 183  ARQLKSCIASIRKEYRKGWAA-KGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCS 359
            AR LK  I  IR  Y K +   K    +Q + A YLIDKLALR GNEK +DEADTVGCC+
Sbjct: 612  ARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 671

Query: 360  LRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            L+VE+++  PP  + FDFLGKDSIRY+N V+V+ AVF  +Q F   K+ S+++
Sbjct: 672  LKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGSEDL 724

[160][TOP]
>UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE
          Length = 2575

 Score =  177 bits (450), Expect = 3e-43
 Identities = 90/173 (52%), Positives = 120/173 (69%), Gaps = 1/173 (0%)
 Frame = +3

Query: 3    PNAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEK 182
            P   +PE P  GH W ++ H++ VTWLAGWK++I    KY+ LSA +  KG +D  K+E 
Sbjct: 2040 PKDKVPEPPA-GHKWKEVKHDNTVTWLAGWKENIQDQNKYIMLSADTHIKGRNDWKKYET 2098

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCS 359
            AR+LK  +  IR++Y +   +K    RQR+TALY IDKLALR G EK AE++ADTVGCCS
Sbjct: 2099 ARKLKEHVDKIRRDYTRDLKSKLMFERQRATALYFIDKLALRAGGEKDAEEQADTVGCCS 2158

Query: 360  LRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            LRVEHL+  P   + FDFLGKDSIRY+N V+VD  V+ N+  F ++K+P D +
Sbjct: 2159 LRVEHLELLPGDELVFDFLGKDSIRYQNQVKVDHQVWKNVGHFKKSKEPGDEL 2211

[161][TOP]
>UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis
            RepID=B9SSQ1_RICCO
          Length = 891

 Score =  177 bits (448), Expect = 5e-43
 Identities = 89/173 (51%), Positives = 122/173 (70%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG +W ++ H++ VTWLA W D I    +KYV+L+A S+ KG SD  K+EK
Sbjct: 516  DAPIPECPIPGESWKEVKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEK 575

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
            AR+LK  I +IR  Y+K   +K    +Q + A YLIDKLALR GNEK +DEADTVGCC+L
Sbjct: 576  ARKLKDYIHNIRAAYQKDLRSKDITKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTL 635

Query: 363  RVEHLKFTPPT-TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            +V +++  P +  + FDFLGKDSIRYEN VEV   V+  +  F + K+ +D++
Sbjct: 636  KVANVECIPGSFNLKFDFLGKDSIRYENTVEVKPEVYEAIGTFQKGKKQTDDL 688

[162][TOP]
>UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG
            RepID=B9Q6S5_TOXGO
          Length = 953

 Score =  177 bits (448), Expect = 5e-43
 Identities = 92/173 (53%), Positives = 118/173 (68%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            +AP+P   +PGH W  + H++ VTWLA ++DSI    KY++L+A S FKG  D  K+EKA
Sbjct: 497  DAPVPRVALPGHAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYEKA 556

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
            R+LK  +  IR++Y K   +     RQ  TA YLID LALRVG EK  ++EADTVGCCSL
Sbjct: 557  RKLKLHVDRIRQDYFKKLESTNSLDRQLGTATYLIDVLALRVGGEKDTDEEADTVGCCSL 616

Query: 363  RVEHLKF-TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            RVEHL F T    V+FDFLGKDSIRY N V+V   VF N+  FC+ K+P D++
Sbjct: 617  RVEHLTFDTEKQEVTFDFLGKDSIRYFNTVKVHPQVFKNVVGFCKGKKPEDDV 669

[163][TOP]
>UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1
            RepID=B9PWF4_TOXGO
          Length = 953

 Score =  177 bits (448), Expect = 5e-43
 Identities = 92/173 (53%), Positives = 118/173 (68%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            +AP+P   +PGH W  + H++ VTWLA ++DSI    KY++L+A S FKG  D  K+EKA
Sbjct: 497  DAPVPRVALPGHAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYEKA 556

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
            R+LK  +  IR++Y K   +     RQ  TA YLID LALRVG EK  ++EADTVGCCSL
Sbjct: 557  RKLKLHVDRIRQDYFKKLESTNSLDRQLGTATYLIDVLALRVGGEKDTDEEADTVGCCSL 616

Query: 363  RVEHLKF-TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            RVEHL F T    V+FDFLGKDSIRY N V+V   VF N+  FC+ K+P D++
Sbjct: 617  RVEHLTFDTEKQEVTFDFLGKDSIRYFNTVKVHPQVFKNVVGFCKGKKPEDDV 669

[164][TOP]
>UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49
            RepID=B6KM03_TOXGO
          Length = 953

 Score =  177 bits (448), Expect = 5e-43
 Identities = 92/173 (53%), Positives = 118/173 (68%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
            +AP+P   +PGH W  + H++ VTWLA ++DSI    KY++L+A S FKG  D  K+EKA
Sbjct: 497  DAPVPRVALPGHAWKDVFHDNSVTWLAFYRDSINDQVKYMYLAAQSKFKGQQDFLKYEKA 556

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
            R+LK  +  IR++Y K   +     RQ  TA YLID LALRVG EK  ++EADTVGCCSL
Sbjct: 557  RKLKLHVDRIRQDYFKKLESTNSLDRQLGTATYLIDVLALRVGGEKDTDEEADTVGCCSL 616

Query: 363  RVEHLKF-TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            RVEHL F T    V+FDFLGKDSIRY N V+V   VF N+  FC+ K+P D++
Sbjct: 617  RVEHLTFDTEKQEVTFDFLGKDSIRYFNTVKVHPQVFKNVVGFCKGKKPEDDV 669

[165][TOP]
>UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi
           RepID=A8Q2Z1_BRUMA
          Length = 751

 Score =  176 bits (446), Expect = 8e-43
 Identities = 93/177 (52%), Positives = 115/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IP+ P  GH W ++ H++ VTWL  W D+I G  KY+ L+  S  KG  D+ KFE A
Sbjct: 385 DSEIPK-PPEGHRWKEVRHDNTVTWLCSWTDNILGSIKYIMLNPSSKIKGEKDYEKFETA 443

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  + SIR+ Y K   +K   VRQR+ ALY IDKLALR GNEK  DE ADTVGCCSL
Sbjct: 444 RRLKDIVGSIRENYTKDLKSKEMRVRQRAVALYFIDKLALRAGNEKDVDEAADTVGCCSL 503

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           R EH++           V FDFLGKDSIRY N V V+K VF NL+LF  NK  SD++
Sbjct: 504 RCEHIQLHEKLDDNDYVVEFDFLGKDSIRYYNKVPVEKRVFKNLKLFMENKSGSDDL 560

[166][TOP]
>UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624
           RepID=Q0CUT4_ASPTN
          Length = 872

 Score =  176 bits (446), Expect = 8e-43
 Identities = 85/154 (55%), Positives = 110/154 (71%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  GH W ++ H+   TWLA W+++I G YKYV L+A S  KG SD+ KFEKAR+LK  I
Sbjct: 429 PPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKARELKKYI 488

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFT 386
             IRK+Y+K    +    RQ++TA+YLID+ ALR GNEK EDEA+TVGCCSL+ E++   
Sbjct: 489 GKIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLKYENVTLK 548

Query: 387 PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           PP  V FDFLGKDSIR+ + V+VD  VF NL++F
Sbjct: 549 PPNKVVFDFLGKDSIRFYDEVDVDPQVFKNLKIF 582

[167][TOP]
>UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732
           RepID=C5DTC9_ZYGRC
          Length = 843

 Score =  175 bits (444), Expect = 1e-42
 Identities = 92/172 (53%), Positives = 114/172 (66%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A IP  P  G  WG+I H++ V WLA W+++I+  +KYV  +A S+  G SD  KFEK+
Sbjct: 395 DATIPPLP-EGQKWGEIRHDNTVQWLAMWRENISNSFKYVRFAANSSLNGQSDFKKFEKS 453

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           RQLK  I +IRK+Y K    K    RQ++ A+YLID  ALR G EKA+DEADTVGCCSLR
Sbjct: 454 RQLKYHIDAIRKDYNKNLKNKVMLERQKAVAIYLIDVFALRAGGEKADDEADTVGCCSLR 513

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+   PP  V FDFLGKDSIR+   VEVD  VF NL +F R  KQP   +
Sbjct: 514 YEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDPQVFKNLTIFKRPPKQPGHQL 565

[168][TOP]
>UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio
           RepID=UPI000176075D
          Length = 531

 Score =  175 bits (443), Expect = 2e-42
 Identities = 92/174 (52%), Positives = 113/174 (64%), Gaps = 6/174 (3%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IPE P  GH W ++ H+  VTWLA W +++ G  KYV L+A S  KG  D  K+E AR+L
Sbjct: 158 IPEAPA-GHKWKEVRHDKTVTWLASWTENVQGSCKYVMLNANSKLKGEKDWEKYEVARKL 216

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVE 371
           K+C+ +IR +Y++   +K    RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVE
Sbjct: 217 KTCVDAIRTQYQEDLKSKQMGTRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVE 276

Query: 372 HLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           H+            V FDFLGKD IRY N V V K VF NL+LF  NKQ  D++
Sbjct: 277 HITLHDALDDQKCVVEFDFLGKDCIRYYNKVPVTKRVFKNLKLFMENKQGGDDL 330

[169][TOP]
>UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC
           6260 RepID=UPI000151AE34
          Length = 754

 Score =  175 bits (443), Expect = 2e-42
 Identities = 92/171 (53%), Positives = 113/171 (66%), Gaps = 5/171 (2%)
 Frame = +3

Query: 21  ECPVP----GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           EC VP    GH WG++ H++ V WLA WK++I+   KYV  +A S+ KG SD  KFE AR
Sbjct: 307 ECKVPEPPAGHKWGEVRHDNTVAWLAMWKENISDSLKYVRFAANSSVKGQSDFKKFETAR 366

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
            LK  I +IR +Y K       + RQ +TA YLID  ALR G EK +DEADTVGCCSLR 
Sbjct: 367 NLKFHIDAIRTDYTKLLKDPLMQNRQMATATYLIDVFALRAGGEKGDDEADTVGCCSLRY 426

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
           EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F +  KQP D++
Sbjct: 427 EHITLKPPNQVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKPPKQPGDDL 477

[170][TOP]
>UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1
           RepID=UPI000023DEFB
          Length = 910

 Score =  175 bits (443), Expect = 2e-42
 Identities = 92/161 (57%), Positives = 108/161 (67%), Gaps = 1/161 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IPE P  GH W  + H+   TWLA W+++I   YKYV L A SA KG SD  KFEKAR
Sbjct: 455 AKIPE-PPKGHQWKAVQHDQKATWLAMWQENINQNYKYVMLGADSAIKGQSDFKKFEKAR 513

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +LK  I  IRK+Y K   ++    RQR+TA+Y IDKLALR GNEK  E+EADTVGCCSL+
Sbjct: 514 ELKKHIDKIRKDYTKELKSEIMADRQRATAMYFIDKLALRAGNEKDTENEADTVGCCSLK 573

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            EH+   PP  V+FDFLGKDSI Y     VD  VF NL+LF
Sbjct: 574 YEHVTLEPPNKVTFDFLGKDSIPYRETAVVDAQVFKNLKLF 614

[171][TOP]
>UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C88D
          Length = 609

 Score =  175 bits (443), Expect = 2e-42
 Identities = 92/174 (52%), Positives = 113/174 (64%), Gaps = 6/174 (3%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IPE P  GH W ++ H+  VTWLA W +++ G  KYV L+A S  KG  D  K+E AR+L
Sbjct: 236 IPEAPA-GHKWKEVRHDKTVTWLASWTENVQGSCKYVMLNANSKLKGEKDWEKYEVARKL 294

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVE 371
           K+C+ +IR +Y++   +K    RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVE
Sbjct: 295 KTCVDAIRTQYQEDLKSKQMGTRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVE 354

Query: 372 HLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           H+            V FDFLGKD IRY N V V K VF NL+LF  NKQ  D++
Sbjct: 355 HITLHDALDDQKCVVEFDFLGKDCIRYYNKVPVTKRVFKNLKLFMENKQGGDDL 408

[172][TOP]
>UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA
          Length = 969

 Score =  175 bits (443), Expect = 2e-42
 Identities = 86/169 (50%), Positives = 110/169 (65%), Gaps = 5/169 (2%)
 Frame = +3

Query: 27   PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
            P PG  W ++ H++ V+WLA W +++ G  KY+ L+  S  KG  D  K+E AR+L   I
Sbjct: 620  PPPGRRWKEVRHDNTVSWLASWVENVQGQVKYIMLNPSSKLKGEKDWQKYETARRLLKHI 679

Query: 207  ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF- 383
              IR  YR  W +K   +RQR+ A+Y IDKLALR GNEK +D+ADTVGCCSLR EH+   
Sbjct: 680  DKIRDTYRDEWKSKEMRIRQRAVAMYFIDKLALRAGNEKDDDQADTVGCCSLRYEHIALH 739

Query: 384  ----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                     V FDFLGKDSIRY N VEV+K VF NL+LF  NK+P D++
Sbjct: 740  KELNGKENVVVFDFLGKDSIRYYNEVEVEKRVFKNLELFKENKKPGDDL 788

[173][TOP]
>UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9SIQ6_9PEZI
          Length = 891

 Score =  175 bits (443), Expect = 2e-42
 Identities = 86/162 (53%), Positives = 115/162 (70%), Gaps = 1/162 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A IP+ P  GH W  ++H++  TWLA W+++I G YKYV   + S+ KG SDH KFEKA
Sbjct: 439 DAKIPK-PPDGHKWKAVVHDNKATWLASWQENINGAYKYVMTGSSSSVKGKSDHMKFEKA 497

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
           R+LK  I  IR++Y K   ++    RQR+TA+YLID+ ALR GNEK AE+EA+TVGCCSL
Sbjct: 498 RELKKHIDRIRRDYGKDLKSETMADRQRATAMYLIDRFALRAGNEKNAEEEAETVGCCSL 557

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           + EH+    P TV FDFLGKDSIR+ +   V++ VF NL++F
Sbjct: 558 KFEHVTLKEPNTVVFDFLGKDSIRFFDEFTVERQVFKNLKIF 599

[174][TOP]
>UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU
          Length = 909

 Score =  175 bits (443), Expect = 2e-42
 Identities = 92/161 (57%), Positives = 108/161 (67%), Gaps = 1/161 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IPE P  GH W  + H+   TWLA W+++I   YKYV L A SA KG SD  KFEKAR
Sbjct: 454 AKIPE-PPKGHQWKAVQHDQKATWLAMWQENINQNYKYVMLGADSAIKGQSDFKKFEKAR 512

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +LK  I  IRK+Y K   ++    RQR+TA+Y IDKLALR GNEK  E+EADTVGCCSL+
Sbjct: 513 ELKKHIDKIRKDYTKELKSEIMADRQRATAMYFIDKLALRAGNEKDTENEADTVGCCSLK 572

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            EH+   PP  V+FDFLGKDSI Y     VD  VF NL+LF
Sbjct: 573 YEHVTLEPPNKVTFDFLGKDSIPYRETAVVDAQVFKNLKLF 613

[175][TOP]
>UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii
           RepID=A5DLX4_PICGU
          Length = 754

 Score =  175 bits (443), Expect = 2e-42
 Identities = 92/171 (53%), Positives = 113/171 (66%), Gaps = 5/171 (2%)
 Frame = +3

Query: 21  ECPVP----GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           EC VP    GH WG++ H++ V WLA WK++I+   KYV  +A S+ KG SD  KFE AR
Sbjct: 307 ECKVPEPPAGHKWGEVRHDNTVAWLAMWKENISDSLKYVRFAANSSVKGQSDFKKFETAR 366

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
            LK  I +IR +Y K       + RQ +TA YLID  ALR G EK +DEADTVGCCSLR 
Sbjct: 367 NLKFHIDAIRTDYTKLLKDPLMQNRQMATATYLIDVFALRAGGEKGDDEADTVGCCSLRY 426

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
           EH+   PP  V FDFLGKDSIR+   VEVDK VF NL++F +  KQP D++
Sbjct: 427 EHITLKPPNQVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKPPKQPGDDL 477

[176][TOP]
>UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3173
          Length = 622

 Score =  174 bits (440), Expect = 4e-42
 Identities = 92/172 (53%), Positives = 112/172 (65%), Gaps = 8/172 (4%)
 Frame = +3

Query: 27  PVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           PVP  GH W ++ H++ VTWLA W ++I G  KY+ L+A S  KG  D  K+E AR+LKS
Sbjct: 248 PVPPAGHRWKEVRHDNTVTWLASWTENIQGSIKYIMLNANSKLKGEKDWEKYEVARKLKS 307

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHL 377
           C+ +IR +Y     ++    RQR+ ALY IDKLALR GNEK E E ADTVGCCSLRVEH+
Sbjct: 308 CVDNIRNQYLMDLKSREMCTRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHI 367

Query: 378 KF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                       V FDFLGKDSIRY N V V K VF NL+LF  +KQP D +
Sbjct: 368 TLHDTLDASECVVEFDFLGKDSIRYYNKVPVIKKVFKNLKLFMEDKQPGDEL 419

[177][TOP]
>UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3S6N7_TRIAD
          Length = 560

 Score =  174 bits (440), Expect = 4e-42
 Identities = 88/177 (49%), Positives = 117/177 (66%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PG  W ++ +++ VTWLA W ++I G  KY+ L+  S  K   D+ K+E A
Sbjct: 184 DAKLP-APPPGQKWKEVRYDNKVTWLASWTENINGSIKYIMLNPTSKIKAEKDYQKYETA 242

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  I  IR++Y+  W +K   +RQRS ALY ID+LALR G+EK E E ADTVGCCSL
Sbjct: 243 RKLKRYIDKIRQDYKADWKSKEMRIRQRSAALYFIDRLALRAGHEKEEGESADTVGCCSL 302

Query: 363 RVEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           R EH+K           V FDFLGKDSIRY N V V+K V+ NL+LFC+NK+  D++
Sbjct: 303 RYEHIKLHDQLEDKMNVVEFDFLGKDSIRYVNQVPVEKQVYKNLKLFCKNKKKGDDL 359

[178][TOP]
>UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea
           RepID=A4R0K7_MAGGR
          Length = 906

 Score =  174 bits (440), Expect = 4e-42
 Identities = 88/161 (54%), Positives = 113/161 (70%), Gaps = 1/161 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A +PE P  GH W  + H++  TWLA W++++ G YKYV L+A SA KG +D  KFEKAR
Sbjct: 453 AKVPEPPA-GHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSAVKGQADFKKFEKAR 511

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +LK  I  IR +Y +   ++    RQR+TA+Y IDKLALR GNEK  E+EA+TVGCCSL+
Sbjct: 512 ELKKHIDRIRADYTRELRSEIMADRQRATAMYFIDKLALRAGNEKDTENEAETVGCCSLK 571

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
           VE++   PP  V  DFLGKDSIR+E  VEVD  VF NL++F
Sbjct: 572 VENVSLQPPNKVFLDFLGKDSIRFEQEVEVDAQVFKNLKMF 612

[179][TOP]
>UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA
          Length = 790

 Score =  174 bits (440), Expect = 4e-42
 Identities = 89/173 (51%), Positives = 119/173 (68%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
           +APIPE P+PG  W +I H++ VTWLA W D I    +KYV+L+A S+ KG     K+EK
Sbjct: 388 DAPIPEPPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGKVTREKYEK 447

Query: 183 ARQLKSCIASIRKE-YRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCS 359
           +R+LK  I  IR   Y K +A+K  + RQ + A YLIDKLALR GNEK +DEADTVGCC+
Sbjct: 448 SRKLKDYIEGIRAAAYTKDFASKDSKKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 507

Query: 360 LRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           L+VE+++   P  + FDFLGKDSIRY+N VEV+  VF  ++ F   K+  D++
Sbjct: 508 LKVENVETKRPNILKFDFLGKDSIRYQNEVEVEPRVFSAIEQFRSGKEGGDDL 560

[180][TOP]
>UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii
           CBS767 RepID=UPI00003BE191
          Length = 789

 Score =  173 bits (439), Expect = 5e-42
 Identities = 89/169 (52%), Positives = 115/169 (68%), Gaps = 1/169 (0%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IPE P  GH W ++ H++ V+WLA WK++I   +KYV  +A S+ KG+SD  KFE +R+L
Sbjct: 345 IPE-PPQGHKWAEVRHDNTVSWLAMWKENIADSFKYVRFAANSSIKGLSDFKKFETSRKL 403

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           +  I  IRK+Y K       + RQ +TA YLID  ALR G EK +DEADTVGCCSLR EH
Sbjct: 404 RYHIDEIRKDYTKMLKDPLMQNRQMATACYLIDIFALRAGGEKGDDEADTVGCCSLRYEH 463

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
           +   PP  V FDFLGKDSIR+   VEV+K VF NL++F +  KQP D++
Sbjct: 464 ITLKPPNKVIFDFLGKDSIRFYQEVEVEKQVFKNLRIFKKPPKQPGDDL 512

[181][TOP]
>UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299
           RepID=C1FD86_9CHLO
          Length = 635

 Score =  173 bits (439), Expect = 5e-42
 Identities = 88/171 (51%), Positives = 114/171 (66%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           A +PE P+PGH W +IIHN+ VTWL GW D+I T  +KYV   A S+ K  SD  K+EKA
Sbjct: 283 AKVPE-PLPGHKWKQIIHNNTVTWLCGWNDTINTKDWKYVQFGATSSIKAESDIQKYEKA 341

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
           R+LK  + +IR++Y K   +     +Q +   YL+DKLALR G EK +D ADTVG C+LR
Sbjct: 342 RKLKLAVDAIRRDYFKKMKSGSVLEQQLAVTTYLVDKLALRAGGEKDDDLADTVGVCTLR 401

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           V H+ F PP+T+ FDFLGKDSIRY    EVD  VF  +Q FC+ K+   +I
Sbjct: 402 VGHIDFLPPSTIKFDFLGKDSIRYLQEHEVDPLVFHAMQRFCKGKKKDQDI 452

[182][TOP]
>UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT
          Length = 926

 Score =  173 bits (439), Expect = 5e-42
 Identities = 88/173 (50%), Positives = 118/173 (68%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG  W ++ +++ VTWLA W D +     KYV+L+A S  KG SD  K+EK
Sbjct: 551  DAPIPECPIPGERWKEVRNDNTVTWLAYWNDPVNLKECKYVFLAASSTLKGQSDKEKYEK 610

Query: 183  ARQLKSCIASIRKEYRKGWAA-KGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCS 359
            AR LK  I  IR  Y K +   K    +Q + A YLIDKLALR GNEK +DEADTVGCC+
Sbjct: 611  ARLLKDYIHGIRAAYTKDFTNNKDPMKKQVAVATYLIDKLALRAGNEKDDDEADTVGCCT 670

Query: 360  LRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            L+VE+++  PP  +  DF+GKDSIRY+N V+V+ AVF  +Q F   K+ S+++
Sbjct: 671  LKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGSEDL 723

[183][TOP]
>UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16
           RepID=A8XXL4_CAEBR
          Length = 840

 Score =  173 bits (439), Expect = 5e-42
 Identities = 91/181 (50%), Positives = 115/181 (63%), Gaps = 13/181 (7%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IP+ P+ GH W ++ H++ V+WL  W +S+ G  KY+ L+A S  KG  D+ K+E AR+L
Sbjct: 453 IPKPPL-GHKWKEVRHDNTVSWLCSWTESVLGQNKYIMLNASSKIKGSKDYEKYETARRL 511

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVE 371
           K  I  IR+ Y   W +K   +RQR+TALY IDKLALR GNEK  DE ADTVGCCSLR E
Sbjct: 512 KKKIGGIRERYIADWKSKEMRIRQRATALYFIDKLALRAGNEKDVDESADTVGCCSLRYE 571

Query: 372 HLKFTPPT------------TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDN 515
           H+K                  V FDFLGKDSIRY N V V+K VF NL+LF  NK+  D+
Sbjct: 572 HIKLFESAKLQETDKKEKEFVVEFDFLGKDSIRYFNRVAVEKRVFKNLKLFMENKKAGDD 631

Query: 516 I 518
           +
Sbjct: 632 L 632

[184][TOP]
>UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA
          Length = 789

 Score =  173 bits (439), Expect = 5e-42
 Identities = 89/169 (52%), Positives = 115/169 (68%), Gaps = 1/169 (0%)
 Frame = +3

Query: 15  IPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQL 194
           IPE P  GH W ++ H++ V+WLA WK++I   +KYV  +A S+ KG+SD  KFE +R+L
Sbjct: 345 IPE-PPQGHKWAEVRHDNTVSWLAMWKENIADSFKYVRFAANSSIKGLSDFKKFETSRKL 403

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           +  I  IRK+Y K       + RQ +TA YLID  ALR G EK +DEADTVGCCSLR EH
Sbjct: 404 RYHIDEIRKDYTKMLKDPLMQNRQMATACYLIDIFALRAGGEKGDDEADTVGCCSLRYEH 463

Query: 375 LKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
           +   PP  V FDFLGKDSIR+   VEV+K VF NL++F +  KQP D++
Sbjct: 464 ITLKPPNKVIFDFLGKDSIRFYQEVEVEKQVFKNLRIFKKPPKQPGDDL 512

[185][TOP]
>UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans
           RepID=O17966-2
          Length = 734

 Score =  173 bits (439), Expect = 5e-42
 Identities = 90/177 (50%), Positives = 111/177 (62%), Gaps = 13/177 (7%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H++ VTWL  W +S+ G  KY+ L+  S  KG  D  K+E AR+LK  I
Sbjct: 365 PPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYETARRLKKKI 424

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR+ Y   + +K   VRQR+TALY IDKLALR GNEK  DE ADTVGCCSLRVEH+K 
Sbjct: 425 GGIRERYTDDFKSKEMRVRQRATALYFIDKLALRAGNEKDVDEAADTVGCCSLRVEHIKL 484

Query: 384 TPPT------------TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                            V FDFLGKDSIRY N V V+K V+ NL++F   K PSD++
Sbjct: 485 FDSAKLNEDDKKEKEFVVEFDFLGKDSIRYFNRVSVEKRVYKNLKIFMEGKAPSDDL 541

[186][TOP]
>UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL
          Length = 806

 Score =  173 bits (439), Expect = 5e-42
 Identities = 90/177 (50%), Positives = 111/177 (62%), Gaps = 13/177 (7%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PGH W ++ H++ VTWL  W +S+ G  KY+ L+  S  KG  D  K+E AR+LK  I
Sbjct: 437 PPPGHKWKEVRHDNTVTWLCSWTESVLGQNKYIMLNPSSKIKGEKDFEKYETARRLKKKI 496

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKF 383
             IR+ Y   + +K   VRQR+TALY IDKLALR GNEK  DE ADTVGCCSLRVEH+K 
Sbjct: 497 GGIRERYTDDFKSKEMRVRQRATALYFIDKLALRAGNEKDVDEAADTVGCCSLRVEHIKL 556

Query: 384 TPPT------------TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                            V FDFLGKDSIRY N V V+K V+ NL++F   K PSD++
Sbjct: 557 FDSAKLNEDDKKEKEFVVEFDFLGKDSIRYFNRVSVEKRVYKNLKIFMEGKAPSDDL 613

[187][TOP]
>UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA
          Length = 892

 Score =  173 bits (438), Expect = 7e-42
 Identities = 86/171 (50%), Positives = 116/171 (67%), Gaps = 1/171 (0%)
 Frame = +3

Query: 9    APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEKA 185
            A +PECP+PG  W  I +++ VTWL  W D I    +KYV+L+A S+ KG SD  K+EKA
Sbjct: 514  AQVPECPIPGEGWKDIRNDNTVTWLCYWSDPINPKLFKYVFLAASSSLKGQSDKEKYEKA 573

Query: 186  RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            R LK  I +IR  Y K + +K    +Q + A YLIDKLALR GNEK +DEADTVGCC+L+
Sbjct: 574  RMLKDYIGNIRAYYTKDFTSKDITKQQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLK 633

Query: 366  VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            VE++    P  + F+FLGKDSI+YEN VEV+  V+  +  F ++K P D++
Sbjct: 634  VENVTRETPNKLKFNFLGKDSIKYENTVEVELPVYNAILKFQKDKGPGDDL 684

[188][TOP]
>UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR
          Length = 874

 Score =  173 bits (438), Expect = 7e-42
 Identities = 91/172 (52%), Positives = 117/172 (68%), Gaps = 2/172 (1%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A +PE P  GH W  + H++  TWLA W+++I G YKYV L+A S  KG +D  KFEKAR
Sbjct: 422 AKVPEPPA-GHKWKAVQHDNKATWLAMWQENINGHYKYVMLAANSTVKGKADFKKFEKAR 480

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +LK  I  IR +Y K   ++    RQR+TA+YLIDK ALR GNEK  E+EA+TVGCCSL+
Sbjct: 481 ELKKYIDRIRADYTKDLKSEVMADRQRATAMYLIDKFALRAGNEKDTENEAETVGCCSLK 540

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR-NKQPSDNI 518
            EH+    P TV FDFLGKDSIR+ N   VD+ VF NL++F +  K+  D+I
Sbjct: 541 YEHVTLREPNTVIFDFLGKDSIRFYNEFTVDRQVFKNLKMFKKPPKEDGDDI 592

[189][TOP]
>UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1
           Tax=Ornithorhynchus anatinus RepID=UPI0001555600
          Length = 689

 Score =  172 bits (437), Expect = 9e-42
 Identities = 90/177 (50%), Positives = 115/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W ++I    KY+ L+  S  KG  D  K+E A
Sbjct: 313 DSKIPE-PPSGHKWKEVRFDNTVTWLASWTENIQNSIKYIMLNPSSKLKGEKDWQKYELA 371

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +YR  W +K  + RQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 372 RRLKGVVDKIRAQYRADWKSKEMKKRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 431

Query: 363 RVEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++           V FDFLGKDSIRY N V V+K V+ NL+LF +NK P D++
Sbjct: 432 RVEHIQLHREMDGQEHVVEFDFLGKDSIRYYNKVPVEKQVYKNLRLFMQNKDPGDDL 488

[190][TOP]
>UniRef100_B8CC91 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B8CC91_THAPS
          Length = 536

 Score =  172 bits (437), Expect = 9e-42
 Identities = 86/189 (45%), Positives = 122/189 (64%), Gaps = 18/189 (9%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP+P C VPGH WG++ H+  V WL  WK++I    KY+ L+A S+FKG SD +K+ KA
Sbjct: 125 DAPVPMCSVPGHAWGEVRHDPTVQWLCQWKENINNQVKYMQLAAQSSFKGKSDRSKYNKA 184

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
            +L   I  IR +Y+K   +K  E RQ +TA+++ID+LALRVG EK  ++EADTVGCCSL
Sbjct: 185 AKLCGNIDKIRTDYKKNLTSKSLETRQLATAMWVIDRLALRVGGEKDTDEEADTVGCCSL 244

Query: 363 RVEHLKFTP------PTTVSFDFLGKDSIRYENAVEVDKA-----------VFFNLQLFC 491
           RVEHLKF P         +  +FLGKDS+ ++  ++   A           V+ N QLFC
Sbjct: 245 RVEHLKFDPNNEGEDSKEIELEFLGKDSMLFKQTIDFGSALYTENNGMGEQVYKNFQLFC 304

Query: 492 RNKQPSDNI 518
           + K+P+D++
Sbjct: 305 KKKKPTDDV 313

[191][TOP]
>UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HDT9_CHAGB
          Length = 907

 Score =  172 bits (437), Expect = 9e-42
 Identities = 88/173 (50%), Positives = 118/173 (68%), Gaps = 2/173 (1%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +A +P  P PGH W  + H++  TWLA W++++ G YKYV L+A S  KG +D  KFEKA
Sbjct: 454 DAKVP-APPPGHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSTVKGQADFKKFEKA 512

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSL 362
           R LK  I  IR +Y +   ++    RQR+TA+YLID+ ALR GNEK  E+EA+TVGCCSL
Sbjct: 513 RDLKKHIDRIRADYTRELKSEVMADRQRATAMYLIDRFALRAGNEKDTENEAETVGCCSL 572

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRN-KQPSDNI 518
           + EH+    P TV FDFLGKDSIR+ N   VD+ VF NL++F ++ K+  D+I
Sbjct: 573 KFEHVTLREPNTVIFDFLGKDSIRFYNEFSVDRQVFKNLKVFKKSPKEDGDDI 625

[192][TOP]
>UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
           RepID=C7YQG7_NECH7
          Length = 919

 Score =  172 bits (437), Expect = 9e-42
 Identities = 89/161 (55%), Positives = 108/161 (67%), Gaps = 1/161 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IP+ P  GH W  + H+   TWLA W+++I   YKYV L A S  KG SD  KFEKAR
Sbjct: 464 AKIPD-PPKGHQWKAVQHDQKATWLAMWQENINNNYKYVMLGAASDIKGQSDFKKFEKAR 522

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +LK  I  IRK+Y K   ++    RQR+TA+YLID+LALR GNEK  E+EADTVGCCSL+
Sbjct: 523 ELKKHIDRIRKDYTKELKSEVMADRQRATAMYLIDRLALRAGNEKDTENEADTVGCCSLK 582

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            EH+   PP  V+FDFLGKDSI Y     V+  VF NL+LF
Sbjct: 583 YEHITLEPPNKVTFDFLGKDSIPYRETAHVEPQVFKNLKLF 623

[193][TOP]
>UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA
          Length = 909

 Score =  171 bits (433), Expect = 3e-41
 Identities = 91/188 (48%), Positives = 120/188 (63%), Gaps = 17/188 (9%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGG-YKYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG +W ++ H++ VTWLA W D I G  +KYV+L+A S+ KG SD  K+EK
Sbjct: 519  DAPIPECPIPGESWKEVRHDNTVTWLAYWNDPINGKEFKYVFLAASSSLKGQSDKEKYEK 578

Query: 183  ARQLKSCIASIRKEYRKGWAAKGKEVRQ----------------RSTALYLIDKLALRVG 314
            AR+LK  I  IR  Y K +++K    RQ                 + A YLIDKLALR G
Sbjct: 579  ARKLKGYIEGIRTAYTKDFSSKDVTKRQIAVATYLIDKLALRAGNAVATYLIDKLALRAG 638

Query: 315  NEKAEDEADTVGCCSLRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
            NEK +DEADTVGCC+L+VE+++      +  DFL KDSIRY+  VEV+  VF  +Q F  
Sbjct: 639  NEKDDDEADTVGCCTLKVENVEPRNNPLLKLDFLPKDSIRYQKRVEVEIPVFKAIQQFRS 698

Query: 495  NKQPSDNI 518
             K+ SDN+
Sbjct: 699  GKKGSDNL 706

[194][TOP]
>UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT
          Length = 926

 Score =  171 bits (433), Expect = 3e-41
 Identities = 88/168 (52%), Positives = 114/168 (67%), Gaps = 2/168 (1%)
 Frame = +3

Query: 6    NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGY-KYVWLSAGSAFKGMSDHAKFEK 182
            +APIPECP+PG  W ++ +++ VTWLA W D I     KYV+L+A S  KG SD  K+EK
Sbjct: 551  DAPIPECPIPGERWKEVRNDNTVTWLAFWNDPINQKECKYVFLAASSTLKGQSDKEKYEK 610

Query: 183  ARQLKSCIASIRKEYRKGWAA-KGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCS 359
            AR LK  I  IR  Y K +   K    +Q + A YLIDKLALR GNEK +DEADTVGCC+
Sbjct: 611  ARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCT 670

Query: 360  LRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQ 503
            L+VE+++  PP  +  DF+GKDSIRY+N V+V+ AVF  +Q F   K+
Sbjct: 671  LKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKE 718

[195][TOP]
>UniRef100_B4E061 cDNA FLJ51170, highly similar to DNA topoisomerase I, mitochondrial
           (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4E061_HUMAN
          Length = 477

 Score =  171 bits (433), Expect = 3e-41
 Identities = 89/177 (50%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +SI    KY+ L+  S  KG +   KFE A
Sbjct: 20  DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFETA 78

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 79  RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 138

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  NK P D++
Sbjct: 139 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDL 195

[196][TOP]
>UniRef100_B4DYD2 cDNA FLJ50294, highly similar to DNA topoisomerase I, mitochondrial
           (EC 5.99.1.2) n=1 Tax=Homo sapiens RepID=B4DYD2_HUMAN
          Length = 503

 Score =  171 bits (433), Expect = 3e-41
 Identities = 89/177 (50%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +SI    KY+ L+  S  KG +   KFE A
Sbjct: 127 DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFETA 185

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 186 RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 245

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  NK P D++
Sbjct: 246 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDL 302

[197][TOP]
>UniRef100_UPI0001AE6F94 UPI0001AE6F94 related cluster n=1 Tax=Homo sapiens
           RepID=UPI0001AE6F94
          Length = 477

 Score =  171 bits (432), Expect = 4e-41
 Identities = 88/177 (49%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE A
Sbjct: 20  DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETA 78

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 79  RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 138

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  NK P D++
Sbjct: 139 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDL 195

[198][TOP]
>UniRef100_B7ZAR5 cDNA, FLJ79279, highly similar to DNA topoisomerase I,
           mitochondrial(EC 5.99.1.2) n=1 Tax=Homo sapiens
           RepID=B7ZAR5_HUMAN
          Length = 503

 Score =  171 bits (432), Expect = 4e-41
 Identities = 88/177 (49%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE A
Sbjct: 127 DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETA 185

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 186 RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 245

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  NK P D++
Sbjct: 246 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDL 302

[199][TOP]
>UniRef100_B7Z9E8 cDNA, FLJ78812, highly similar to DNA topoisomerase I,
           mitochondrial (EC 5.99.1.2) n=1 Tax=Homo sapiens
           RepID=B7Z9E8_HUMAN
          Length = 503

 Score =  171 bits (432), Expect = 4e-41
 Identities = 88/177 (49%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE A
Sbjct: 127 DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETA 185

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 186 RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 245

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  NK P D++
Sbjct: 246 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDL 302

[200][TOP]
>UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens
           RepID=TOP1M_HUMAN
          Length = 601

 Score =  171 bits (432), Expect = 4e-41
 Identities = 88/177 (49%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE A
Sbjct: 225 DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETA 283

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 284 RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 343

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  NK P D++
Sbjct: 344 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDL 400

[201][TOP]
>UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei
           RepID=Q581U8_9TRYP
          Length = 661

 Score =  170 bits (430), Expect = 6e-41
 Identities = 87/162 (53%), Positives = 108/162 (66%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIP+ P  GH W  ++H+  VTWLA W +   G  KYV L+  S  KG SD+AKFE AR
Sbjct: 244 APIPQAPA-GHKWKGVVHDQNVTWLAMWYEPTIGQCKYVMLAPSSTLKGQSDYAKFETAR 302

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK+ I  IR+ Y K +++  +  RQR+ A Y IDKLALRVG+EK E+EADTVGCCSLR 
Sbjct: 303 ELKNHIDDIRESYTKDFSSTDEMERQRAVATYFIDKLALRVGHEKGEEEADTVGCCSLRK 362

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
           EH++  P   V FDFLGKDSIRY N V V   V+  L  F +
Sbjct: 363 EHIELRPDNVVRFDFLGKDSIRYVNEVTVLPEVYKLLGSFIK 404

[202][TOP]
>UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma
           brucei RepID=C9ZLY6_TRYBG
          Length = 696

 Score =  170 bits (430), Expect = 6e-41
 Identities = 87/162 (53%), Positives = 108/162 (66%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           APIP+ P  GH W  ++H+  VTWLA W +   G  KYV L+  S  KG SD+AKFE AR
Sbjct: 279 APIPQAPA-GHKWKGVVHDQNVTWLAMWYEPTIGQCKYVMLAPSSTLKGQSDYAKFETAR 337

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK+ I  IR+ Y K +++  +  RQR+ A Y IDKLALRVG+EK E+EADTVGCCSLR 
Sbjct: 338 ELKNHIDDIRESYTKDFSSTDEMERQRAVATYFIDKLALRVGHEKGEEEADTVGCCSLRK 397

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCR 494
           EH++  P   V FDFLGKDSIRY N V V   V+  L  F +
Sbjct: 398 EHIELRPDNVVRFDFLGKDSIRYVNEVTVLPEVYKLLGSFIK 439

[203][TOP]
>UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes
           RepID=TOP1M_PANTR
          Length = 601

 Score =  170 bits (430), Expect = 6e-41
 Identities = 88/177 (49%), Positives = 114/177 (64%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ VTWLA W +S+    KY+ L+  S  KG +   KFE A
Sbjct: 225 DSKIPEPPA-GHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETA 283

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+L+  +  IR +YR  W ++  + RQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 284 RRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSL 343

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V FDFLGKD IRY N V V+K V+ NLQLF  +K P DN+
Sbjct: 344 RVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNL 400

[204][TOP]
>UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina
           RepID=B2AY06_PODAN
          Length = 904

 Score =  169 bits (429), Expect = 8e-41
 Identities = 85/161 (52%), Positives = 111/161 (68%), Gaps = 1/161 (0%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A +P+ P  GH W  + H++  TWLA W++++ G YKYV L+A S  KG +D+ KFEKAR
Sbjct: 452 AKVPDPPA-GHKWKAVQHDNKATWLAMWQENVNGNYKYVMLAANSTVKGQADYKKFEKAR 510

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
           +L   IA IR +Y     ++    RQR+TA+YLIDK ALR GNEK  E+EA+TVGCCSL+
Sbjct: 511 ELNKHIARIRADYTAELKSEIMAERQRATAMYLIDKFALRAGNEKDTENEAETVGCCSLK 570

Query: 366 VEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLF 488
            EH+    P TV FDFLGKDSIR+ N   V++ VF NL+LF
Sbjct: 571 FEHVTLREPNTVIFDFLGKDSIRFYNEFTVERQVFKNLKLF 611

[205][TOP]
>UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva
            RepID=Q4N5U3_THEPA
          Length = 1003

 Score =  169 bits (427), Expect = 1e-40
 Identities = 89/176 (50%), Positives = 115/176 (65%), Gaps = 5/176 (2%)
 Frame = +3

Query: 6    NAPIPECPV---PGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKF 176
            +AP+P+       GH+W  I H++ VTWLA +KDSI   +KY++LSA S FKG  D  K+
Sbjct: 506  DAPVPKVSNFQREGHSWKDIYHDNSVTWLAYYKDSINDQFKYMYLSAQSKFKGFHDFLKY 565

Query: 177  EKARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCC 356
             KAR+LK+ I  IR +Y     +     +Q  TA+YLID LALRVG EK  DEADTVGCC
Sbjct: 566  NKARELKAYIQKIRDDYNTKMLSMDIYEKQLGTAVYLIDFLALRVGGEKDADEADTVGCC 625

Query: 357  SLRVEHLKFT--PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            SLRVEH+KF+     T++ DFLGKDSIRY N V ++   + NL  FC  K+ S+ I
Sbjct: 626  SLRVEHIKFSEKKQNTITLDFLGKDSIRYFNTVTLNDVAYDNLAKFCHRKKASEEI 681

[206][TOP]
>UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545
           RepID=C1MGX0_9CHLO
          Length = 685

 Score =  167 bits (424), Expect = 3e-40
 Identities = 86/170 (50%), Positives = 110/170 (64%), Gaps = 1/170 (0%)
 Frame = +3

Query: 12  PIPECPVPGHNWGKIIHNSCVTWLAGWKDSI-TGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           P P+ P PGH W  +IHN  VTWL GW D+I T  +KYV   A S+ K  SD  K+EKAR
Sbjct: 337 PAPD-PGPGHKWKDVIHNDTVTWLCGWNDTINTKDWKYVQFGAMSSIKAESDIQKYEKAR 395

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRV 368
           +LK  + +IR++Y K         +Q +   YL+DKLALR G EK ED ADTVG C+LRV
Sbjct: 396 KLKLAVDAIRRDYFKKMKTGDMLAKQLAVTTYLVDKLALRAGGEKDEDLADTVGVCTLRV 455

Query: 369 EHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
            H++F  P+T+  DFLGKDSIRY    EVD  VF  +Q FC+ K+P ++I
Sbjct: 456 GHVEFITPSTLKLDFLGKDSIRYLQEHEVDPLVFEAMQKFCKGKKPDNDI 505

[207][TOP]
>UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI
          Length = 638

 Score =  167 bits (424), Expect = 3e-40
 Identities = 87/166 (52%), Positives = 111/166 (66%), Gaps = 5/166 (3%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P  G  W ++ H++ VTWLA W D++ G  KY+ L++ S  +  SDH K+E AR+L   I
Sbjct: 258 PPRGQMWKEVRHDNTVTWLASWVDNVQGQSKYIILNSWSKIRCESDHNKYETARRLHKFI 317

Query: 207 ASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLK-- 380
             IR  YR+ W +K   VRQR+ ALY IDKLALRVGNEK +D+ADTVGCCSLRVEH++  
Sbjct: 318 DKIRATYREEWKSKDIFVRQRAVALYFIDKLALRVGNEKEKDQADTVGCCSLRVEHVQLH 377

Query: 381 ---FTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPS 509
                    V+FDFLGKDSIRY   VEV+  VF NL+LF ++K  S
Sbjct: 378 RRLMDKEYVVAFDFLGKDSIRYYKTVEVEPRVFNNLKLFVKDKGKS 423

[208][TOP]
>UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus
           RepID=UPI00017968A4
          Length = 655

 Score =  167 bits (422), Expect = 5e-40
 Identities = 88/177 (49%), Positives = 112/177 (63%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IP+ P  GH W ++  ++ VTWLA W ++I    KYV L+  S  KG  D  K+E A
Sbjct: 279 DSKIPKPPA-GHQWKEVRSDNTVTWLASWTENIQNSIKYVMLNPSSKLKGEKDWQKYEVA 337

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +YR  W ++  + RQ + ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 338 RRLKGVVDEIRSQYRADWKSREMKKRQCAVALYFIDKLALRAGNEKEEGETADTVGCCSL 397

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++  P        V  DFLGKDSIRY N V V+K V+ NLQLF  NK   D++
Sbjct: 398 RVEHIQLYPEADGCQHVVELDFLGKDSIRYYNRVPVEKPVYKNLQLFMENKSRGDDL 454

[209][TOP]
>UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG
          Length = 622

 Score =  166 bits (420), Expect = 9e-40
 Identities = 92/181 (50%), Positives = 112/181 (61%), Gaps = 17/181 (9%)
 Frame = +3

Query: 27  PVP--GHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           PVP  GH W ++ H++ VTWLA W ++I G  KY+ L+A S  KG  D  K+E AR+LKS
Sbjct: 227 PVPPAGHRWKEVRHDNTVTWLASWTENIQGSIKYIMLNANSKLKGEKDWEKYEVARKLKS 286

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLID---------KLALRVGNEKAEDE-ADTVG 350
           C+ +IR +Y     ++    RQR+ ALY ID         KLALR GNEK E E ADTVG
Sbjct: 287 CVDNIRNQYLMDLKSREMCTRQRAVALYFIDKVGVTVVILKLALRAGNEKEEGETADTVG 346

Query: 351 CCSLRVEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDN 515
           CCSLRVEH+            V FDFLGKDSIRY N V V K VF NL+LF  +KQP D 
Sbjct: 347 CCSLRVEHITLHDTLDASECVVEFDFLGKDSIRYYNKVPVIKKVFKNLKLFMEDKQPGDE 406

Query: 516 I 518
           +
Sbjct: 407 L 407

[210][TOP]
>UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei
           RepID=Q4YYG2_PLABE
          Length = 805

 Score =  165 bits (418), Expect = 1e-39
 Identities = 92/206 (44%), Positives = 119/206 (57%), Gaps = 35/206 (16%)
 Frame = +3

Query: 6   NAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP P     + GHNWG I H++ VTWLA +KDSI    KY +LSA S FKG  D  K+E
Sbjct: 334 DAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 393

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
            AR+LKSC+  IRK+Y+    +K    +Q  TA+YLID LALRVG EK  ++EADTVGCC
Sbjct: 394 NARKLKSCVHKIRKDYQNKMKSKNIINKQLGTAVYLIDFLALRVGGEKDIDEEADTVGCC 453

Query: 357 SLRVEHLKFT--------------------------------PPTTVSFDFLGKDSIRYE 440
           SLRVEH+ F+                                    V+ DFLGKDSIRY 
Sbjct: 454 SLRVEHVSFSHNVIIKNENTNDENDNKISKIPLPKNLEDILEDDCYVTLDFLGKDSIRYF 513

Query: 441 NAVEVDKAVFFNLQLFCRNKQPSDNI 518
           N V++DK  + N+ +FC+NK   + +
Sbjct: 514 NTVKIDKQAYINMIIFCKNKNKDEGV 539

[211][TOP]
>UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO
          Length = 701

 Score =  165 bits (418), Expect = 1e-39
 Identities = 87/173 (50%), Positives = 111/173 (64%), Gaps = 4/173 (2%)
 Frame = +3

Query: 6   NAPIPECPV---PGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKF 176
           +AP+P+  +    GH W  I H+S VTWLA ++D++    KY++ +A S FKG+ D  K+
Sbjct: 287 DAPVPKVSMFERQGHGWSDIFHDSSVTWLAYYRDTVNDQTKYMYPAAQSKFKGLHDFLKY 346

Query: 177 EKARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCC 356
            KAR+LK  I  IRK+Y     +     RQ  TA YLID LALRVG EK  DEADTVGCC
Sbjct: 347 SKARELKKHIMKIRKDYHGKMRSPEIVDRQLGTATYLIDFLALRVGGEKDADEADTVGCC 406

Query: 357 SLRVEHLKF-TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSD 512
           SLRVEH+KF   P T++ DFLGKDSIRY + V +D+    NL  FC+ K   D
Sbjct: 407 SLRVEHIKFDRKPNTITLDFLGKDSIRYFHTVTLDEVACRNLSEFCKKKPTED 459

[212][TOP]
>UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=Q0V9D3_XENTR
          Length = 495

 Score =  164 bits (415), Expect = 3e-39
 Identities = 84/152 (55%), Positives = 105/152 (69%), Gaps = 6/152 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P PGH W ++ H++ VTWLA W +++ G  KY+ L+A S  KG  D  K+E A
Sbjct: 305 DSKIPE-PPPGHKWKEVRHDNTVTWLASWTENVQGSVKYIMLNANSKLKGEKDWEKYEVA 363

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  + +IRK YR+ + +K  +VRQR+ ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 364 RKLKHHVVTIRKTYRENFKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSL 423

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYEN 443
           RVEH+K  P        V FDFLGKDSIRY N
Sbjct: 424 RVEHIKLYPELDGDKYVVEFDFLGKDSIRYYN 455

[213][TOP]
>UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1
            Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO
          Length = 886

 Score =  164 bits (415), Expect = 3e-39
 Identities = 91/206 (44%), Positives = 118/206 (57%), Gaps = 35/206 (16%)
 Frame = +3

Query: 6    NAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
            +AP P     + GHNWG I H++ VTWLA +KDSI    KY +LSA S FKG  D  K+E
Sbjct: 389  DAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 448

Query: 180  KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
             AR+LKSC+  IRK+Y+     K    +Q  TA+YLID LALRVG EK  ++EADTVGCC
Sbjct: 449  NARKLKSCVHKIRKDYQNKMKNKNIVNKQLGTAVYLIDFLALRVGGEKDIDEEADTVGCC 508

Query: 357  SLRVEHLKFT--------------------------------PPTTVSFDFLGKDSIRYE 440
            SLRVEH+ F+                                    ++ DFLGKDSIRY 
Sbjct: 509  SLRVEHVSFSHNVIIKNENTNDENDNKISKIPLPKNLEDILEDDCYITLDFLGKDSIRYF 568

Query: 441  NAVEVDKAVFFNLQLFCRNKQPSDNI 518
            N V++DK  + N+ +FC+NK   + +
Sbjct: 569  NTVKIDKQAYINMIIFCKNKNKDEGV 594

[214][TOP]
>UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7
          Length = 839

 Score =  163 bits (413), Expect = 6e-39
 Identities = 92/208 (44%), Positives = 120/208 (57%), Gaps = 37/208 (17%)
 Frame = +3

Query: 6   NAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP+P     + GHNWG I H++ VTWLA +KDSI    KY +LSA S FKG  D  K+E
Sbjct: 337 DAPVPRLYDNMCGHNWGDIYHDNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDLMKYE 396

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
            AR+LKSC+  IR++Y+     K    +Q  TA+YLID LALRVG EK  ++EADTVGCC
Sbjct: 397 NARKLKSCVHKIREDYKNKMKNKNIIDKQLGTAVYLIDFLALRVGGEKDIDEEADTVGCC 456

Query: 357 SLRVEHLKFTP------------------------PTT----------VSFDFLGKDSIR 434
           SLRVEH+ F                          PT           ++ DFLGKDSIR
Sbjct: 457 SLRVEHISFAHDIPFKSVDSKEQKTNDEKVNKIPLPTNLESISSEDCYITLDFLGKDSIR 516

Query: 435 YENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           Y N V++DK  + N+ +FC+NK   + +
Sbjct: 517 YFNTVKIDKQAYINIIIFCKNKNRDEGV 544

[215][TOP]
>UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE
          Length = 592

 Score =  162 bits (409), Expect = 2e-38
 Identities = 87/177 (49%), Positives = 111/177 (62%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ V WLA W + I   +KYV L+  S  KG  D  K+E A
Sbjct: 217 DSKIPEPPA-GHQWKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYEVA 275

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +Y+  W +   + RQ + ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 276 RRLKGVVDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSL 335

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++   P       V  DFLGKDSIRY+N V V+K VF NLQ F  +K P D++
Sbjct: 336 RVEHIRLHAPAGGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDL 392

[216][TOP]
>UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus
           RepID=TOP1M_RAT
          Length = 593

 Score =  162 bits (409), Expect = 2e-38
 Identities = 86/177 (48%), Positives = 112/177 (63%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ V WLA W ++I   +KY+ L+  S  KG  D  K+E A
Sbjct: 218 DSKIPEPPA-GHQWKEVRSDNTVMWLAAWVENIQNSFKYIILNPSSKPKGEMDWQKYEVA 276

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +Y+  W +   + RQ + ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 277 RRLKGVVDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSL 336

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++   P       V  DFLGKDSIRY+N V V+K VF NLQ F  +K P D++
Sbjct: 337 RVEHVRLHTPADGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDL 393

[217][TOP]
>UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus
           RepID=TOP1M_MOUSE
          Length = 593

 Score =  162 bits (409), Expect = 2e-38
 Identities = 87/177 (49%), Positives = 111/177 (62%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ IPE P  GH W ++  ++ V WLA W + I   +KYV L+  S  KG  D  K+E A
Sbjct: 218 DSKIPEPPA-GHQWKEVRSDNTVMWLAAWVEHIQNSFKYVILNPSSKPKGEMDWQKYEVA 276

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R+LK  +  IR +Y+  W +   + RQ + ALY IDKLALR GNEK E E ADTVGCCSL
Sbjct: 277 RRLKGVVDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSL 336

Query: 363 RVEHLKFTPPT-----TVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           RVEH++   P       V  DFLGKDSIRY+N V V+K VF NLQ F  +K P D++
Sbjct: 337 RVEHIRLHAPAGGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDL 393

[218][TOP]
>UniRef100_A4S5R8 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4S5R8_OSTLU
          Length = 491

 Score =  159 bits (403), Expect = 8e-38
 Identities = 82/172 (47%), Positives = 106/172 (61%), Gaps = 1/172 (0%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAGSAFKGMSDHAKFEK 182
           +A +PE P  GH+W  +IHN   TWLAGW D I    +KYV   A S  K  SD  K+EK
Sbjct: 127 DAKVPEPPA-GHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYEK 185

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR L   I  IRK+Y++   ++ KE+ Q + A YL+DKLALR G EK ED ADTVG C+L
Sbjct: 186 ARSLHKYIEKIRKDYKRNMMSESKEMAQLAVATYLVDKLALRAGGEKDEDLADTVGVCTL 245

Query: 363 RVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           R  H+KF     + FDFLGKDSI+Y    ++D+  +  LQ F + K P  +I
Sbjct: 246 RAGHIKFMDDNVIEFDFLGKDSIQYLQQHKIDEVAYKCLQRFVQGKGPDVDI 297

[219][TOP]
>UniRef100_UPI000180B1AE PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Ciona
           intestinalis RepID=UPI000180B1AE
          Length = 482

 Score =  159 bits (402), Expect = 1e-37
 Identities = 87/177 (49%), Positives = 110/177 (62%), Gaps = 6/177 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           N+ IP+ P  GH W ++ H++ VTWL  W +++    KY+ L+  S  KG  D  K+E A
Sbjct: 105 NSKIPKPPA-GHKWKEVRHDNAVTWLVSWTENVQNQNKYIMLNPSSRVKGEKDWQKYEVA 163

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSL 362
           R LKS +  IR++Y +   +    VRQR+ ALY IDKLALR GNEK + E ADTVGCCSL
Sbjct: 164 RNLKSKVDRIREDYMRDLKSDEMMVRQRAVALYFIDKLALRAGNEKEDGESADTVGCCSL 223

Query: 363 RVEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           R EH+K           V FDFLGKDSIRY N V V K VF NL LF  NK+  D++
Sbjct: 224 RCEHIKLHKHLDGKDFIVEFDFLGKDSIRYYNKVPVLKQVFKNLVLFTENKEGPDDL 280

[220][TOP]
>UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B5Y3I3_PHATR
          Length = 594

 Score =  159 bits (402), Expect = 1e-37
 Identities = 83/188 (44%), Positives = 116/188 (61%), Gaps = 18/188 (9%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           AP+P CPVPGH W  + H+    WLA WK++I    KY+ L+A S+FKG SD +K+ KA 
Sbjct: 192 APVPPCPVPGHAWSDVRHDPRGQWLATWKENINNQSKYMQLAAQSSFKGKSDRSKYSKAG 251

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCCSLR 365
            L   I  IRK Y+K   +K  EV+Q +TA ++ID+LALRVG EK  ++EADTVGCCSLR
Sbjct: 252 LLCKNIEKIRKSYKKDLKSKDMEVKQLATATWVIDRLALRVGGEKDTDEEADTVGCCSLR 311

Query: 366 VEHLKFTP------PTTVSFDFLGKDSIRYENAVE-----------VDKAVFFNLQLFCR 494
           VEHL F P         +  +FLGKDS+ ++  ++           +   V+ NL+ FC+
Sbjct: 312 VEHLHFDPNGEGGDSKEIELEFLGKDSMLFKQTIDFGATLYNDSNGLGAQVYDNLKSFCK 371

Query: 495 NKQPSDNI 518
            K+ S+ +
Sbjct: 372 KKKSSEEV 379

[221][TOP]
>UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri
           RepID=Q00XV7_OSTTA
          Length = 783

 Score =  155 bits (393), Expect = 1e-36
 Identities = 77/165 (46%), Positives = 101/165 (61%), Gaps = 1/165 (0%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSIT-GGYKYVWLSAGSAFKGMSDHAKFEKARQLKSC 203
           P PGH+W  +IHN   TWLAGW D I    +KYV   A S  K  SD  K+EKAR L   
Sbjct: 413 PPPGHSWKAVIHNDTATWLAGWNDVINVKDWKYVQFGATSTVKAESDQKKYEKARSLHKF 472

Query: 204 IASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKF 383
           I  IR +Y++   ++ +E+ Q +   YL+DKLALR G EK ED ADTVG C+LR  H+KF
Sbjct: 473 IEKIRADYKRNMQSESREMAQLAVTTYLVDKLALRAGGEKDEDLADTVGVCTLRAGHIKF 532

Query: 384 TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
                + FDFLGKDSI+Y    ++D+  +  LQ F ++K P  +I
Sbjct: 533 MEDNVIEFDFLGKDSIQYLQQHKIDEVAYKCLQRFVKDKGPDVDI 577

[222][TOP]
>UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata
            RepID=Q4UDP8_THEAN
          Length = 999

 Score =  155 bits (392), Expect = 2e-36
 Identities = 88/184 (47%), Positives = 113/184 (61%), Gaps = 13/184 (7%)
 Frame = +3

Query: 6    NAPIPECPV---PGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKF 176
            +AP+P+       GH+W  I H++ VTWLA +KDSI   +KY++LSA S FKG  D  K+
Sbjct: 507  DAPVPKVTNFQREGHSWKDIYHDNSVTWLAYYKDSINDQFKYMYLSAQSKFKGFHDFLKY 566

Query: 177  EKARQLKSCIASIRKEYRKGWAAK--------GKEVRQRSTALYLIDKLALRVGNEKAED 332
             KAR+LK+ I  IR +Y                   +Q  TA+YLID LALRVG EK  D
Sbjct: 567  NKARELKAYIQKIRDDYNTKMLCMTIIYTITLDIYEKQLGTAVYLIDYLALRVGGEKDAD 626

Query: 333  EADTVGCCSLRVEHLKFT--PPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQP 506
            EADTVGCCSLRVEH+KF+     T++ DFLGKDSIRY N   ++   + NL  FC  K+ 
Sbjct: 627  EADTVGCCSLRVEHIKFSEKKKNTITLDFLGKDSIRYFNT--LNDVAYDNLAKFCNRKKS 684

Query: 507  SDNI 518
            S+ I
Sbjct: 685  SEGI 688

[223][TOP]
>UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA
          Length = 1019

 Score =  149 bits (376), Expect = 1e-34
 Identities = 73/168 (43%), Positives = 107/168 (63%), Gaps = 1/168 (0%)
 Frame = +3

Query: 12  PIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQ 191
           P P+ P    +W +++    VTWLA WK++I G YKYV+L A S FK  SD  KFEKAR+
Sbjct: 344 PAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFEKARK 403

Query: 192 LKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVE 371
           L + +  IR++  K   +K +  RQ +T ++LID  +LR GNEK EDEA+T G CSLR E
Sbjct: 404 LDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCE 463

Query: 372 HLKFTPPTTVSFDFLGKDSIRYENAVEV-DKAVFFNLQLFCRNKQPSD 512
           H +   P T+  +FLGKDS+++E  +++ +  VF N+ +F ++    D
Sbjct: 464 HAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKD 511

[224][TOP]
>UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PY85_MALGO
          Length = 877

 Score =  148 bits (374), Expect = 2e-34
 Identities = 73/173 (42%), Positives = 107/173 (61%), Gaps = 6/173 (3%)
 Frame = +3

Query: 18  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLK 197
           P  P  GH+WG+++    VTWLA W+++I GG+KYV+L A S FK  SD  KFEKAR+L 
Sbjct: 304 PPKPPKGHSWGEVVERKDVTWLALWRENINGGFKYVFLDASSTFKTESDREKFEKARRLD 363

Query: 198 SCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL 377
           +C+  +R +  K   +K +  +  +T ++LID  +LR GNEK EDEA+T G CSLR  H 
Sbjct: 364 TCVKQVRADVLKNLRSKDRLDQMIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCGHA 423

Query: 378 KFTPPTTVSFDFLGKDSIRYENAVEV-DKAVFFNLQLFCRN-----KQPSDNI 518
              PP  ++  FLGKDS+++E  + + +  V+ N+  F ++     K P D I
Sbjct: 424 TLIPPNQLNLSFLGKDSMKFEETLTITNPHVYKNITSFLKSDGHQKKGPDDPI 476

[225][TOP]
>UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE
          Length = 725

 Score =  147 bits (370), Expect = 5e-34
 Identities = 73/126 (57%), Positives = 91/126 (72%), Gaps = 2/126 (1%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSIT--GGYKYVWLSAGSAFKGMSDHAKFEK 182
           AP+P+C +PGH+WGKI+H + VTWL  + DS      +KYV  +A S FK M+D  K+EK
Sbjct: 210 APVPQCKLPGHSWGKIVHRNDVTWLFSYVDSSIRKDNHKYVQFAATSRFKQMNDKRKYEK 269

Query: 183 ARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSL 362
           AR+LK+ I  IR+ Y K   +   + RQ  TA YLIDKLALRVGN+K EDEADTVGCCSL
Sbjct: 270 ARRLKNQIDQIRENYTKKLQSDSIKERQLGTATYLIDKLALRVGNDKDEDEADTVGCCSL 329

Query: 363 RVEHLK 380
           RVEH+K
Sbjct: 330 RVEHIK 335

[226][TOP]
>UniRef100_Q5BXE0 SJCHGC03473 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BXE0_SCHJA
          Length = 238

 Score =  140 bits (354), Expect = 4e-32
 Identities = 74/135 (54%), Positives = 90/135 (66%), Gaps = 5/135 (3%)
 Frame = +3

Query: 129 LSAGSAFKGMSDHAKFEKARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALR 308
           L+  S  KG  D  K+E AR L   I  IR +YR  +  K   +RQR+ ALY IDKLALR
Sbjct: 1   LNPSSRLKGEKDWKKYETARCLHKVIDKIRADYRADFKHKEMRIRQRAVALYFIDKLALR 60

Query: 309 VGNEKAEDEADTVGCCSLRVEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFF 473
            GNEK EDEADTVGCCSLR EH+K        P  V FDFLGKDSIRY+N+V V K VF 
Sbjct: 61  AGNEKDEDEADTVGCCSLRYEHIKLHEELNGQPYVVEFDFLGKDSIRYQNSVSVPKRVFK 120

Query: 474 NLQLFCRNKQPSDNI 518
           N++LF +NK+ +D++
Sbjct: 121 NVKLFLKNKKENDDL 135

[227][TOP]
>UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H
           RepID=B3L6G4_PLAKH
          Length = 924

 Score =  137 bits (344), Expect = 6e-31
 Identities = 74/150 (49%), Positives = 98/150 (65%), Gaps = 3/150 (2%)
 Frame = +3

Query: 6   NAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP+P     + GH+WG I H++ VTWLA +KDSI    KY +LSA S FKG  D  K+E
Sbjct: 371 DAPVPRLYGDMCGHSWGDIYHDNKVTWLAYYKDSINDQLKYTFLSAQSKFKGYKDFLKYE 430

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
            AR+LKSC+  IR++Y+    +K    +Q  TA+YLID LALRVG EK  ++EADTVGCC
Sbjct: 431 NARKLKSCVHKIREDYKHKMKSKNILEKQLGTAVYLIDFLALRVGGEKDIDEEADTVGCC 490

Query: 357 SLRVEHLKFTPPTTVSFDFLGKDSIRYENA 446
           SLRVEH+ F+    +       + +R ENA
Sbjct: 491 SLRVEHVSFSHEVPIK-----NECLRGENA 515

[228][TOP]
>UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A2H9_NITMS
          Length = 551

 Score =  135 bits (339), Expect = 2e-30
 Identities = 79/169 (46%), Positives = 100/169 (59%), Gaps = 3/169 (1%)
 Frame = +3

Query: 21  ECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           E  VP   WGKIIH+    WLA W D +T   KYVWLS  S  K   D  K+EKA +L+ 
Sbjct: 175 EAKVPEGKWGKIIHDKDSMWLASWMDFLTQKRKYVWLSDSSDLKQGRDKEKYEKAVKLEK 234

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLK 380
            I  I+K   K    K  +    +TA YLI K A+RVG+EK EDEADTVG  +LR EH+K
Sbjct: 235 EIEKIKKAMVKD--MKDSKKNNVATACYLIYKTAMRVGDEKDEDEADTVGATTLRKEHIK 292

Query: 381 FTPPTTVSFDFLGKDSIRYENAVEV---DKAVFFNLQLFCRNKQPSDNI 518
            T   T+ FDFLGKDS+R++  ++V   DK    NL+     K+PS+ I
Sbjct: 293 IT-SDTIEFDFLGKDSVRWQETLKVVGDDKQFQENLKKLIEKKKPSEEI 340

[229][TOP]
>UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax
           RepID=A5KB33_PLAVI
          Length = 931

 Score =  133 bits (334), Expect = 8e-30
 Identities = 72/144 (50%), Positives = 93/144 (64%), Gaps = 3/144 (2%)
 Frame = +3

Query: 6   NAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP+P     + GH WG   H++ VTWLA +KDSI    KY +LSA S FKG  D  K+E
Sbjct: 371 DAPVPRLYDDMCGHCWGDTYHDNKVTWLAYYKDSINDQLKYTFLSAQSKFKGYKDFLKYE 430

Query: 180 KARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEK-AEDEADTVGCC 356
            AR+LKSC+  IR++YR     K    +Q  TA+YLID LALRVG EK  ++EADTVGCC
Sbjct: 431 NARKLKSCVHKIREDYRHKMRNKSILDKQLGTAVYLIDFLALRVGGEKDIDEEADTVGCC 490

Query: 357 SLRVEHLKFTPPTTVSFDFLGKDS 428
           SLRVEH+ F+    +  +  G+ S
Sbjct: 491 SLRVEHVSFSHEVPIKNESRGERS 514

[230][TOP]
>UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)
           (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD
          Length = 620

 Score =  129 bits (324), Expect = 1e-28
 Identities = 76/173 (43%), Positives = 98/173 (56%), Gaps = 6/173 (3%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           ++ +PE P  G  W ++  +  V WLA W +++    KYV L+ G   KG  D  K+E A
Sbjct: 180 DSTVPEPPA-GPQWKEVGCDCTVMWLAAWTENVQNFIKYVTLNPGCKLKGERDWGKYEAA 238

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLR 365
            +LK  +  I  +YR    +     RQR+ ALY I+KLAL+ GN   E+     GCCSLR
Sbjct: 239 WRLKGAVGKICSQYRTAGTSPEMRTRQRAVALYFINKLALQTGN--GEEGGGLGGCCSLR 296

Query: 366 VEHLKFTP-----PTTVSFDFLGKDSIRYENAVEVDK-AVFFNLQLFCRNKQP 506
           VEHL+  P     P  V FDFLGKDSIR  N V V+K  V+ NLQLF  NK P
Sbjct: 297 VEHLQLYPEASGSPDVVEFDFLGKDSIRSYNRVLVEKLQVYRNLQLFMDNKGP 349

[231][TOP]
>UniRef100_B3TAG0 Putative eukaryotic DNA topoisomerase I, catalytic core n=1
           Tax=uncultured marine crenarchaeote HF4000_APKG8D22
           RepID=B3TAG0_9ARCH
          Length = 563

 Score =  127 bits (318), Expect = 6e-28
 Identities = 65/169 (38%), Positives = 99/169 (58%), Gaps = 3/169 (1%)
 Frame = +3

Query: 21  ECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           E  +P   WGKI+H+    W+A W D +T   KYVWL+  +  K   D AK++KA+ L  
Sbjct: 182 EAKIPEAKWGKIVHDRNSMWIASWMDILTQKRKYVWLADTAGIKQEMDQAKYDKAKNLSK 241

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLK 380
            I +++ +  K   +  ++ ++ +TA YLI + ++RVG+EK  DEADTVG  +LR EH+K
Sbjct: 242 EIENVKAQIIKDMQSNEQKNKRIATACYLIYRTSMRVGDEKDPDEADTVGATTLRKEHIK 301

Query: 381 FTPPTTVSFDFLGKDSIRYENAVEV---DKAVFFNLQLFCRNKQPSDNI 518
            +    + FDFLGKD +R+   +     DK  + NL+ F  NK+ S  I
Sbjct: 302 LS-ENAIEFDFLGKDGVRWRETIPAEGHDKQFYDNLKEFIANKKESQEI 349

[232][TOP]
>UniRef100_B3T4E9 Putative eukaryotic DNA topoisomerase I, catalytic core n=1
           Tax=uncultured marine crenarchaeote HF4000_ANIW133O4
           RepID=B3T4E9_9ARCH
          Length = 563

 Score =  127 bits (318), Expect = 6e-28
 Identities = 65/169 (38%), Positives = 99/169 (58%), Gaps = 3/169 (1%)
 Frame = +3

Query: 21  ECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKS 200
           E  +P   WGKI+H+    W+A W D +T   KYVWL+  +  K   D AK++KA+ L  
Sbjct: 182 EAKIPEAKWGKIVHDRNSMWIASWMDILTQKRKYVWLADTAGIKQEMDQAKYDKAKNLSK 241

Query: 201 CIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLK 380
            I +++ +  K   +  ++ ++ +TA YLI + ++RVG+EK  DEADTVG  +LR EH+K
Sbjct: 242 EIENVKAQIIKDMQSNEQKNKRIATACYLIYRTSMRVGDEKDPDEADTVGATTLRKEHIK 301

Query: 381 FTPPTTVSFDFLGKDSIRYENAVEV---DKAVFFNLQLFCRNKQPSDNI 518
            +    + FDFLGKD +R+   +     DK  + NL+ F  NK+ S  I
Sbjct: 302 LS-ENAIEFDFLGKDGVRWRETIPAEGHDKQFYDNLKEFIANKKESQEI 349

[233][TOP]
>UniRef100_C3ZV88 Putative uncharacterized protein (Fragment) n=1 Tax=Branchiostoma
           floridae RepID=C3ZV88_BRAFL
          Length = 299

 Score =  124 bits (311), Expect = 4e-27
 Identities = 66/116 (56%), Positives = 77/116 (66%), Gaps = 6/116 (5%)
 Frame = +3

Query: 150 KGMSDHAKFEKARQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAE 329
           +G  D  K+E AR+L  C+  IR +YR+ W +K   +RQR+ ALY IDKLALR GNEK  
Sbjct: 2   QGEKDWMKYETARKLHKCVDRIRAQYREEWKSKEMRIRQRAVALYFIDKLALRAGNEKDS 61

Query: 330 DE-ADTVGCCSLRVEHLKF-----TPPTTVSFDFLGKDSIRYENAVEVDKAVFFNL 479
           DE ADTVGCCSLRVEH+            V FDFLGKDSIRY N V V+K VF NL
Sbjct: 62  DEAADTVGCCSLRVEHINLHREHEGKEFVVEFDFLGKDSIRYHNFVAVEKKVFKNL 117

[234][TOP]
>UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum
           RepID=A0RU10_CENSY
          Length = 519

 Score =  117 bits (293), Expect = 5e-25
 Identities = 65/165 (39%), Positives = 95/165 (57%), Gaps = 3/165 (1%)
 Frame = +3

Query: 33  PGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCIAS 212
           P   W KI+H     W+A W D++    KYVWL+  +  K   D +K+EKA  L   I  
Sbjct: 176 PPGKWKKIVHEKDGIWIAKWTDNLVKKDKYVWLADTAGLKQERDRSKYEKAVALSKKIGE 235

Query: 213 IRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHLKFTPP 392
           I  +  K   +K  ++ + +TA YLI + A+RVG+EK +DEADTVG  +LR EH++ +  
Sbjct: 236 IEAKIVKDMKSKDPKISKIATACYLIYRTAMRVGDEKDKDEADTVGATTLRKEHIRIS-D 294

Query: 393 TTVSFDFLGKDSIRYENAVEV---DKAVFFNLQLFCRNKQPSDNI 518
             + FDFLGKDSIR+   ++V   D+    NLQ   ++ +P D I
Sbjct: 295 GVIEFDFLGKDSIRWNEKLKVTGDDEQFSRNLQGLVKSIKPKDEI 339

[235][TOP]
>UniRef100_B3GD27 Topoisomerase I (Fragment) n=1 Tax=Macrogyrus oblongus
           RepID=B3GD27_9COLE
          Length = 263

 Score =  116 bits (291), Expect = 8e-25
 Identities = 61/92 (66%), Positives = 67/92 (72%), Gaps = 5/92 (5%)
 Frame = +3

Query: 258 VRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL-----KFTPPTTVSFDFLGK 422
           VRQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+     K      V FDFLGK
Sbjct: 2   VRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIELHEQKDDKEYVVVFDFLGK 61

Query: 423 DSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           DSIRY N V V+K VF NLQLF  NK P D++
Sbjct: 62  DSIRYYNEVPVEKRVFKNLQLFMENKSPGDDL 93

[236][TOP]
>UniRef100_B3GD25 Topoisomerase I (Fragment) n=1 Tax=Amphizoa lecontei
           RepID=B3GD25_AMPLE
          Length = 268

 Score =  116 bits (290), Expect = 1e-24
 Identities = 60/92 (65%), Positives = 68/92 (73%), Gaps = 5/92 (5%)
 Frame = +3

Query: 258 VRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL-----KFTPPTTVSFDFLGK 422
           +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+     K      V FDFLGK
Sbjct: 2   IRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIELHEQKDDKEFVVVFDFLGK 61

Query: 423 DSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           DSIRY N V V+K VF NLQLF  NK P+D++
Sbjct: 62  DSIRYYNEVPVEKRVFKNLQLFMENKAPADDL 93

[237][TOP]
>UniRef100_B3GD30 Topoisomerase I (Fragment) n=1 Tax=Metrius contractus
           RepID=B3GD30_METCO
          Length = 281

 Score =  113 bits (282), Expect = 9e-24
 Identities = 58/92 (63%), Positives = 66/92 (71%), Gaps = 5/92 (5%)
 Frame = +3

Query: 258 VRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL-----KFTPPTTVSFDFLGK 422
           +RQR+ ALY ID+LALR GNEK ED+ADTVGCCSLRVEH+     K        FDFLGK
Sbjct: 2   IRQRAVALYFIDRLALRAGNEKDEDQADTVGCCSLRVEHISLHEQKDGKEYVTVFDFLGK 61

Query: 423 DSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           DSIRY N V V+K VF NLQLF  NK P D++
Sbjct: 62  DSIRYYNEVPVEKRVFKNLQLFMENKSPGDDL 93

[238][TOP]
>UniRef100_B3GD28 Topoisomerase I (Fragment) n=1 Tax=Calosoma scrutator
           RepID=B3GD28_CALSB
          Length = 281

 Score =  113 bits (282), Expect = 9e-24
 Identities = 59/92 (64%), Positives = 66/92 (71%), Gaps = 5/92 (5%)
 Frame = +3

Query: 258 VRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEHL-----KFTPPTTVSFDFLGK 422
           +RQR+ ALY IDKLALR GNEK ED+ADTVGCCSLRVEH+     K      V FDFLGK
Sbjct: 2   IRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHITLHEQKDDKEYVVVFDFLGK 61

Query: 423 DSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           DSIRY N V V+K VF NLQLF  NK   D++
Sbjct: 62  DSIRYYNEVPVEKRVFKNLQLFMENKSAGDDL 93

[239][TOP]
>UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DC43
          Length = 343

 Score =  108 bits (271), Expect = 2e-22
 Identities = 59/113 (52%), Positives = 75/113 (66%)
 Frame = +3

Query: 6   NAPIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKA 185
           +AP P   +PG  W  I H++ VTWLA   ++I   +KYV+L+AGS+ KG SD AKFEKA
Sbjct: 156 DAPTPIPNIPG-KWKAIQHDNTVTWLATRTENINQSHKYVFLAAGSSLKGRSDMAKFEKA 214

Query: 186 RQLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADT 344
           R+LK  +  IR+ Y     +K    RQR+TA   +DKLALR GNEK EDEADT
Sbjct: 215 RELKIHVDRIRQNYTVDLKSKVMAERQRATATCFVDKLALRAGNEKGEDEADT 267

[240][TOP]
>UniRef100_Q9D6H0 Putative uncharacterized protein n=1 Tax=Mus musculus
           RepID=Q9D6H0_MOUSE
          Length = 295

 Score =  104 bits (259), Expect = 4e-21
 Identities = 56/92 (60%), Positives = 64/92 (69%), Gaps = 6/92 (6%)
 Frame = +3

Query: 261 RQRSTALYLIDKLALRVGNEKAEDE-ADTVGCCSLRVEHLKFTPPT-----TVSFDFLGK 422
           RQ + ALY IDKLALR GNEK E E ADTVGCCSLRVEH++   P       V  DFLGK
Sbjct: 4   RQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHIRLHAPAGGQEHVVELDFLGK 63

Query: 423 DSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           DSIRY+N V V+K VF NLQ F  +K P D++
Sbjct: 64  DSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDL 95

[241][TOP]
>UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI
          Length = 557

 Score =  100 bits (248), Expect = 8e-20
 Identities = 59/171 (34%), Positives = 91/171 (53%), Gaps = 6/171 (3%)
 Frame = +3

Query: 18  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFK-GMSDHAKFEKARQL 194
           P  P PGH W +++H+  V+WL  W D ++G   YV      + +  +    + E AR+L
Sbjct: 233 PPAPPPGHRWRQVVHDRSVSWLYSWHDLVSGNTYYVRARIDQSKRYRLPLRNQLETARRL 292

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           +  + SIR+EYR+ W++    VRQRS ALY ID+LA+     +  ++ D V  C LRVE+
Sbjct: 293 QQHLPSIRREYRQLWSSDQWLVRQRSVALYCIDQLAMTC---EDPEQPDKVTLCDLRVEN 349

Query: 375 LKFTP-----PTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSD 512
           L+  P        V       +  R   +V V   VF+NL++F   K+P+D
Sbjct: 350 LQLHPRLAGKKNVVRLQARKSNRQRVYRSVCVQPEVFYNLRVFVSGKEPND 400

[242][TOP]
>UniRef100_B7QCX5 DNA topoisomerase type I, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7QCX5_IXOSC
          Length = 250

 Score = 94.0 bits (232), Expect = 5e-18
 Identities = 52/80 (65%), Positives = 58/80 (72%), Gaps = 6/80 (7%)
 Frame = +3

Query: 297 LALRVGNEKAEDE-ADTVGCCSLRVEHL-----KFTPPTTVSFDFLGKDSIRYENAVEVD 458
           LALR GNEK E E ADTVGCCSLRVEHL     K      V FDFLGKDSIRY NAV V+
Sbjct: 2   LALRAGNEKEEGETADTVGCCSLRVEHLTLHDSKDGKEFVVEFDFLGKDSIRYVNAVPVE 61

Query: 459 KAVFFNLQLFCRNKQPSDNI 518
           K VF NL+LF  NK+P+D++
Sbjct: 62  KRVFRNLKLFMENKKPADDL 81

[243][TOP]
>UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q9Y0_IXOSC
          Length = 499

 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 43/97 (44%), Positives = 62/97 (63%)
 Frame = +3

Query: 9   APIPECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKAR 188
           A IP  P  GH W ++ H++ V+WL+ W ++I G  KY+ L+  S  KG  D  K+E AR
Sbjct: 404 AKIPP-PPEGHRWKEVRHDNTVSWLSSWTENILGQTKYIMLNPSSKLKGEKDMQKYEMAR 462

Query: 189 QLKSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKL 299
           +LKS +  IR++Y + W +K   +RQRS ALY IDK+
Sbjct: 463 KLKSKVGVIREDYMRDWKSKEMRIRQRSVALYFIDKV 499

[244][TOP]
>UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE
          Length = 469

 Score = 79.7 bits (195), Expect = 1e-13
 Identities = 33/81 (40%), Positives = 50/81 (61%)
 Frame = +3

Query: 27  PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFEKARQLKSCI 206
           P PG  W ++ H++ VTWL  W ++I G  KY+ L+  S  KG  D  K+E AR+LK C+
Sbjct: 388 PPPGTKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV 447

Query: 207 ASIRKEYRKGWAAKGKEVRQR 269
             IR +YR  W +K K+ +++
Sbjct: 448 DRIRSQYRDDWKSKKKKKKKK 468

[245][TOP]
>UniRef100_A5BM51 Putative uncharacterized protein n=1 Tax=Vitis vinifera
            RepID=A5BM51_VITVI
          Length = 1449

 Score = 74.3 bits (181), Expect = 4e-12
 Identities = 35/66 (53%), Positives = 48/66 (72%)
 Frame = +3

Query: 321  KAEDEADTVGCCSLRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNK 500
            K +DEADTVGCC+L+VE++   PP ++ FDFLGKDSIRYE  VEV+  V+  ++ F   K
Sbjct: 1202 KDDDEADTVGCCTLKVENVIPEPPNSLQFDFLGKDSIRYEKTVEVELPVYKAIEQFRVGK 1261

Query: 501  QPSDNI 518
              SD++
Sbjct: 1262 SGSDDL 1267

[246][TOP]
>UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO
          Length = 555

 Score = 74.3 bits (181), Expect = 4e-12
 Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 7/172 (4%)
 Frame = +3

Query: 18  PECPVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKF-EKARQL 194
           P  P  GH W  ++H+  V W+  W D +TG   + +    S+ +         + AR+L
Sbjct: 230 PPAPPCGHLWAAVVHDRTVRWVYAWNDIVTGCMHHAYPRNESSRRSRPPRRDLLDTARRL 289

Query: 195 KSCIASIRKEYRKGWAAKGKEVRQRSTALYLIDKLALRVGNEKAEDEADTVGCCSLRVEH 374
           +  +  IR EY+   +++   VRQRS ALY ID+LA+    E+   E    G C   V++
Sbjct: 290 QQHLHHIRNEYQTLQSSENWLVRQRSVALYCIDQLAMSCDAEEVPAETTVCGLC---VQN 346

Query: 375 LKFTPPTTVSFDFL-----GKDSIRYE-NAVEVDKAVFFNLQLFCRNKQPSD 512
           +K  P      + L      +D  + E     V   +F+NL +F   KQP +
Sbjct: 347 IKLCPRLGGQRNVLQLLAGNRDCRQREYKRSSVPPGIFYNLSVFICGKQPDE 398

[247][TOP]
>UniRef100_Q7YZP3 Topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania panamensis
           RepID=Q7YZP3_9TRYP
          Length = 88

 Score = 70.9 bits (172), Expect = 5e-11
 Identities = 35/60 (58%), Positives = 40/60 (66%)
 Frame = +3

Query: 339 DTVGCCSLRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           DTVGCCSLRVEH++      V FDFLGKDSIRY+N V V   V+  LQ F R K P  +I
Sbjct: 1   DTVGCCSLRVEHIQLMSDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGTDI 60

[248][TOP]
>UniRef100_Q9NGZ9 Topoisomerase I (Fragment) n=1 Tax=Leishmania donovani
           RepID=Q9NGZ9_LEIDO
          Length = 89

 Score = 68.9 bits (167), Expect = 2e-10
 Identities = 34/58 (58%), Positives = 39/58 (67%)
 Frame = +3

Query: 345 VGCCSLRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQPSDNI 518
           VGCCSLRVEH++  P   V FDFLGKDSIRY+N V V   V+  LQ F R K P  +I
Sbjct: 4   VGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGMDI 61

[249][TOP]
>UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi
           RepID=Q4XMK5_PLACH
          Length = 429

 Score = 68.9 bits (167), Expect = 2e-10
 Identities = 35/66 (53%), Positives = 43/66 (65%), Gaps = 2/66 (3%)
 Frame = +3

Query: 6   NAPIPEC--PVPGHNWGKIIHNSCVTWLAGWKDSITGGYKYVWLSAGSAFKGMSDHAKFE 179
           +AP P     + GHNWG I H++ VTWLA +KDSI    KY +LSA S FKG  D  K+E
Sbjct: 364 DAPAPRLYDDMCGHNWGDIYHDNKVTWLAYYKDSINDQIKYTFLSAQSKFKGYKDFLKYE 423

Query: 180 KARQLK 197
            AR+LK
Sbjct: 424 NARKLK 429

[250][TOP]
>UniRef100_Q56X27 DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana
           RepID=Q56X27_ARATH
          Length = 270

 Score = 67.8 bits (164), Expect = 4e-10
 Identities = 30/64 (46%), Positives = 45/64 (70%)
 Frame = +3

Query: 327 EDEADTVGCCSLRVEHLKFTPPTTVSFDFLGKDSIRYENAVEVDKAVFFNLQLFCRNKQP 506
           ++EADTVGCC+L+V +++  PP  + FDFLGKDSI+Y N VEV+  V+  +  F   K  
Sbjct: 1   DNEADTVGCCTLKVGNVECIPPNKIKFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAGKSK 60

Query: 507 SDNI 518
           +D++
Sbjct: 61  TDDL 64