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[1][TOP] >UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum RepID=TOP1_DICDI Length = 893 Score = 134 bits (338), Expect = 3e-30 Identities = 63/147 (42%), Positives = 92/147 (62%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 281 E E +G +WW+ + D KWTTL HNG FPP Y PHG +Y+G + L P EE Sbjct: 289 EEEEEEGVNKWWDKEDDEDDGTKWTTLIHNGPVFPPAYVPHGIKFMYDGKVVKLTPKQEE 348 Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 461 VATFYA+ L+TDHV K+ F+ NFF +F+ LL + +++ ++KCDFS I HL+ +K Sbjct: 349 VATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKE 407 Query: 462 KKKAEKKAQTTAERKEAREAEAERVRQ 542 ++KA K E K+A AE +++++ Sbjct: 408 QRKARSK-----EEKDAETAEKKKIQE 429 [2][TOP] >UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus RepID=A5E508_LODEL Length = 849 Score = 134 bits (337), Expect = 4e-30 Identities = 77/187 (41%), Positives = 108/187 (57%), Gaps = 7/187 (3%) Frame = +3 Query: 3 KVKAE----RRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVK 170 KVKAE + + K E S +G + E D G++WWEA ++ DGE+K Sbjct: 168 KVKAEPSTKKTTKASQVKKETSVKSETPESGDGGDDDDEEEEDAGYKWWEAQDEHDGEIK 227 Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344 WT+LEHNGV FPPEYE P L Y+G ++LP AEEVA F+ + ++TDH F+ Sbjct: 228 WTSLEHNGVMFPPEYEPLPSHVKLYYDGKPVNLPVEAEEVAGFFGAMVETDHAKNPVFQK 287 Query: 345 NFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521 NFF DF+ +L ++ V I EK DFS+I A+ E KK+ EKKA + E+K +E Sbjct: 288 NFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE----KKREEKKAMSREEKKRLKE- 342 Query: 522 EAERVRQ 542 E +R+ + Sbjct: 343 EKDRIEE 349 [3][TOP] >UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187E0BD Length = 265 Score = 133 bits (335), Expect = 7e-30 Identities = 75/183 (40%), Positives = 102/183 (55%), Gaps = 4/183 (2%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188 K ++R K + E+ T SP + G E E + ++WWE N+ D VKWTTLEH Sbjct: 33 KPKKRAPKAKKEQEETTSSPTKGKGKK--RKEDEEQEDVYKWWENNNE-DSSVKWTTLEH 89 Query: 189 NGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADF 362 NGV FPP YEP + Y+G L+LPP +EEVA FYA+ ++TDH F NFF D+ Sbjct: 90 NGVIFPPPYEPLPSNVKMKYDGKVLNLPPESEEVAGFYAALIETDHAQDATFNKNFFEDW 149 Query: 363 RALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536 +L D + +T +KCDF + + E EKAKKKA A+ +K+ EAEA+ Sbjct: 150 LKVLQDHPPRNGIKVTDFDKCDFRPMYEYFEAEKAKKKAMSAAEKKEIKKQKDEAEAKYT 209 Query: 537 RQF 545 F Sbjct: 210 HCF 212 [4][TOP] >UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36 RepID=B9WIH6_CANDC Length = 777 Score = 126 bits (316), Expect = 1e-27 Identities = 75/185 (40%), Positives = 100/185 (54%), Gaps = 4/185 (2%) Frame = +3 Query: 3 KVKAERRVAGG-KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179 K K E + A K K E ++ S +A+ +E D G++WWEA +TD +KW T Sbjct: 103 KSKKESKTASSTKVKEEPKSQSDSQASVK----SETPEEDQGYKWWEANEETDDIIKWQT 158 Query: 180 LEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 LEHNGV FPP YE P L Y ++LPP AEEVA FY + L+TDH F+ NFF Sbjct: 159 LEHNGVIFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 218 Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 DF +L + V I EK DFS++ AH E K + EKKA + E+K +E + + Sbjct: 219 NDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE----KLREEKKAMSKEEKKRIKEEKEK 274 Query: 531 RVRQF 545 F Sbjct: 275 EEEPF 279 [5][TOP] >UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404 RepID=C5M985_CANTT Length = 777 Score = 125 bits (313), Expect = 3e-27 Identities = 74/176 (42%), Positives = 99/176 (56%), Gaps = 15/176 (8%) Frame = +3 Query: 36 KAKTEDRTL--------SPGRAAGSPLGAAEGE-NGDGGFRWWEAGNKTDGEVKWTTLEH 188 KAK E TL SP + P + E D G++WWEA +T+G +KW TLEH Sbjct: 102 KAKKEKSTLKKEPKSKESPTKLKKEPTKSETPEAEEDEGYKWWEATEETEGGIKWETLEH 161 Query: 189 NGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADF 362 NGV FPPEYE P L Y+G ++LPP AEEVA FY + L+TDH F+ NFF DF Sbjct: 162 NGVIFPPEYEPLPSHVKLYYDGKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDF 221 Query: 363 RALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERKEARE 518 +L + V I EK DFS++ A+ E ++ +KKA ++K + ER + E Sbjct: 222 LEVLKECGGCGVEIKEFEKMDFSKMYAYYEQQREEKKALSRDEKKRLKEERDKFEE 277 [6][TOP] >UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59XR0_CANAL Length = 780 Score = 124 bits (311), Expect = 5e-27 Identities = 76/186 (40%), Positives = 100/186 (53%), Gaps = 8/186 (4%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTT 179 VK E + K K E +T S +A+ +E D G++WWE + +G+ +KW T Sbjct: 106 VKKESKATSTKVKEESKTQSDSQASVK----SETPEEDQGYKWWEVNQEEEGDGYIKWQT 161 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 LEHNGV FPP YEP L Y ++LPP AEEVA FY + L+TDH F+ NFF Sbjct: 162 LEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 221 Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER---KEAREA 521 DF +L + V I EK DFS++ AH E K + EKKA + E+ KE +E Sbjct: 222 NDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEK 277 Query: 522 EAERVR 539 E E R Sbjct: 278 EEEPYR 283 [7][TOP] >UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL Length = 778 Score = 124 bits (311), Expect = 5e-27 Identities = 76/186 (40%), Positives = 100/186 (53%), Gaps = 8/186 (4%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTT 179 VK E + K K E +T S +A+ +E D G++WWE + +G+ +KW T Sbjct: 104 VKKESKATSTKVKEESKTQSDSQASVK----SETPEEDQGYKWWEVNQEEEGDGYIKWQT 159 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 LEHNGV FPP YEP L Y ++LPP AEEVA FY + L+TDH F+ NFF Sbjct: 160 LEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 219 Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER---KEAREA 521 DF +L + V I EK DFS++ AH E K + EKKA + E+ KE +E Sbjct: 220 NDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEK 275 Query: 522 EAERVR 539 E E R Sbjct: 276 EEEPYR 281 [8][TOP] >UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans RepID=Q59WV6_CANAL Length = 780 Score = 123 bits (309), Expect = 8e-27 Identities = 76/186 (40%), Positives = 100/186 (53%), Gaps = 8/186 (4%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTT 179 VK E + K K E +T S +A+ +E D G++WWE + +G+ +KW T Sbjct: 106 VKKESKATSTKVKEESKTQSDSQASVK----SETLEEDQGYKWWEVNQEEEGDGYIKWQT 161 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 LEHNGV FPP YEP L Y ++LPP AEEVA FY + L+TDH F+ NFF Sbjct: 162 LEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 221 Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER---KEAREA 521 DF +L + V I EK DFS++ AH E K + EKKA + E+ KE +E Sbjct: 222 NDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEK 277 Query: 522 EAERVR 539 E E R Sbjct: 278 EEEPYR 283 [9][TOP] >UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5LJG7_9ALVE Length = 551 Score = 120 bits (301), Expect = 7e-26 Identities = 61/129 (47%), Positives = 82/129 (63%) Frame = +3 Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308 RWWE + D KW+ LEH+G+ F P YEPHG ++Y+G + LPP AEEVATF+A L Sbjct: 83 RWWEK-DPEDNAAKWSYLEHHGMIFTPPYEPHGVKMLYKGEPIDLPPEAEEVATFFAQTL 141 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ KKA K + Sbjct: 142 GTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLDKRSEAKKARTKEE 200 Query: 489 TTAERKEAR 515 AE++ R Sbjct: 201 KEAEKEAKR 209 [10][TOP] >UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5L755_9ALVE Length = 647 Score = 120 bits (301), Expect = 7e-26 Identities = 61/129 (47%), Positives = 82/129 (63%) Frame = +3 Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308 RWWE + D KW+ LEH+G+ F P YEPHG ++Y+G + LPP AEEVATF+A L Sbjct: 83 RWWEK-DPEDNAAKWSYLEHHGMIFTPPYEPHGVKMLYKGEPIDLPPEAEEVATFFAQTL 141 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 TD KEKF++NF+ADF+A L +K IT L+ CDF I+ +L+ KKA K + Sbjct: 142 GTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLDKRSEAKKARTKEE 200 Query: 489 TTAERKEAR 515 AE++ R Sbjct: 201 KEAEKEAKR 209 [11][TOP] >UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0UUB0_PHANO Length = 887 Score = 120 bits (300), Expect = 8e-26 Identities = 73/155 (47%), Positives = 84/155 (54%), Gaps = 10/155 (6%) Frame = +3 Query: 96 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 269 AAE E + +RWWE K DG KW TLEHNGV FPPEY P LIY+G+ + L P Sbjct: 234 AAEDEEEE--YRWWEDTAKGDGSKKWDTLEHNGVVFPPEYVPLPKNVKLIYDGIPVTLQP 291 Query: 270 AAEEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDF 425 AEE ATFY S L + H V F NFF DF A+L T K I EKCDF Sbjct: 292 EAEEAATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDF 351 Query: 426 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 I H E ++A KKA A+ A + E AEAE Sbjct: 352 KPIFEHFEADRAAKKALPAAEKKALKAEKDAAEAE 386 [12][TOP] >UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QNQ2_PENMQ Length = 860 Score = 120 bits (300), Expect = 8e-26 Identities = 77/190 (40%), Positives = 101/190 (53%), Gaps = 16/190 (8%) Frame = +3 Query: 6 VKAERRVAGGKA-KTEDRT-LSPGRAAGSPLGA----AEGENGDGGFRWWEAGNKTDGEV 167 VK E V KA K+E T G+ +P+ A EG + +RWWE K DG + Sbjct: 169 VKTENGVGAKKAIKSEPSTPAKKGKGKATPVKAESEDVEGAEEEEEYRWWEDPTKGDGTI 228 Query: 168 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKF 338 KW TLEHNGV FPPEYE P + Y+G+ + L P AEEVA F+ + L + H V F Sbjct: 229 KWNTLEHNGVVFPPEYEPLPKNVKMKYDGVPVVLHPEAEEVAGFFGAMLNSTHNVENPTF 288 Query: 339 RSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 497 + NFF DF+A+L T AK I +KCDF I + E ++ +KK A+ A Sbjct: 289 QKNFFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIFEYYEGKRLEKKNLSAAEKKA 348 Query: 498 ERKEAREAEA 527 + E EAEA Sbjct: 349 LKAERDEAEA 358 [13][TOP] >UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum RepID=Q94705_PHYPO Length = 1015 Score = 119 bits (298), Expect = 1e-25 Identities = 72/178 (40%), Positives = 99/178 (55%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188 K E + GG+AK + + EGE G+ ++WWE DG+ +WT+L H Sbjct: 373 KKEVKEEGGEAKKKGKK-------------KEGE-GEEEWKWWEEEALPDGK-RWTSLVH 417 Query: 189 NGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRA 368 NGV F Y HG Y+G ++L P AEEVATFYA L+TD+ KE F +NF++DFR Sbjct: 418 NGVVFVEPYVAHGVKFYYDGKPINLSPEAEEVATFYAKYLETDYPKKENFNTNFWSDFRT 477 Query: 369 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 L + KVI K DF+ I +L ++K E KA TAE K+A +AE E++ Q Sbjct: 478 YLTPEQ-KKVIKDFSKADFTHIHKYLVEQK-----ELKANRTAEEKKAEKAEKEKLLQ 529 [14][TOP] >UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST Length = 780 Score = 119 bits (298), Expect = 1e-25 Identities = 67/148 (45%), Positives = 88/148 (59%), Gaps = 3/148 (2%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281 E+ D G++WWEA + DG KW TLEHNGV FPPEYEP L Y+G + L AEE Sbjct: 137 EDEDEGYKWWEAED-VDGVQKWETLEHNGVLFPPEYEPLPSHVKLYYDGKPVKLSLEAEE 195 Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 458 VA FY + L+TDH F+ NFF DF ++ +T + V I EK DFS+I AH E Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE--- 252 Query: 459 AKKKAEKKAQTTAERKEAREAEAERVRQ 542 K E+K T ++K+A + E ER+ + Sbjct: 253 --KLREEKKLLTKDQKKAMKEEKERIEE 278 [15][TOP] >UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe RepID=TOP1_SCHPO Length = 814 Score = 119 bits (297), Expect = 2e-25 Identities = 61/141 (43%), Positives = 84/141 (59%), Gaps = 2/141 (1%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281 E+ D ++WW + N D + KWTTLEHNGV F P YEP LIY+G ++LPP AEE Sbjct: 175 EDEDEDYKWWTSENIDDTQ-KWTTLEHNGVIFAPPYEPLPKNVKLIYDGNPVNLPPEAEE 233 Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 461 VA FYA+ L+TDH F+ NFF DF + + F I KCDF+++ H E ++ Sbjct: 234 VAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFEQKRE 293 Query: 462 KKKAEKKAQTTAERKEAREAE 524 +KK+ K Q A +++ E E Sbjct: 294 EKKSMPKEQKKAIKQKKDEEE 314 [16][TOP] >UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI Length = 760 Score = 118 bits (296), Expect = 2e-25 Identities = 67/156 (42%), Positives = 94/156 (60%), Gaps = 9/156 (5%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLI--YEGMELHLPPAA 275 E E + ++WWE N+ D +KW TLEH GV FPPEYEP ++ Y+G + LP AA Sbjct: 113 ETEEAEDVYKWWENDNQDDS-IKWETLEHKGVMFPPEYEPLPKSVLMKYDGTPVVLPHAA 171 Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI 434 EEVA F+ + L+TDH F+ NFF DF+A+L ++ AK I + KCDFS + Sbjct: 172 EEVAGFFGAMLETDHAKNPTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDM 231 Query: 435 EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 AH E K + EKKA + AE+K A +AE +++ + Sbjct: 232 YAHFE----KMREEKKAMSAAEKK-AIKAERDKIEE 262 [17][TOP] >UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8N6Y9_COPC7 Length = 863 Score = 118 bits (296), Expect = 2e-25 Identities = 73/181 (40%), Positives = 94/181 (51%), Gaps = 7/181 (3%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSP--GRAAGSPLGAAEGENGDGGFRWWEAGNKT-DGEVKW 173 + K A GK K E+ SP G+ E E + F+WWEAG+ DG KW Sbjct: 200 EAKPSASKANGKVKKEEPA-SPVKGKGKKGKQKEEEEEEEEEVFKWWEAGDVNGDGTQKW 258 Query: 174 TTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 TLEHNGVYFPP YE P + Y G ++ L AEEVA FY + L+TDH F N Sbjct: 259 ETLEHNGVYFPPPYEALPKHVKMKYNGKDVDLSIEAEEVAGFYGALLETDHAKDATFNKN 318 Query: 348 FFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521 FF DF+ +L + IT+ E CDF + + E EKAK+KA + A +K+ E Sbjct: 319 FFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAEKAKRKAMTNEEKKAAKKKKDEL 378 Query: 522 E 524 E Sbjct: 379 E 379 [18][TOP] >UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MH68_TALSN Length = 864 Score = 117 bits (293), Expect = 6e-25 Identities = 74/189 (39%), Positives = 97/189 (51%), Gaps = 15/189 (7%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRT-LSPGRAAGSPLGA----AEGENGDGGFRWWEAGNKTDGEVK 170 VK E V K K E T + G+ +P+ E + +RWWE K DG +K Sbjct: 174 VKTENGVGTKKIKAEPSTPVKKGKGKATPVKEESEDVEAAEEEEEYRWWEDPTKGDGTIK 233 Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFR 341 WTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L + H V F+ Sbjct: 234 WTTLEHNGVVFPPPYEPLPKNVKMKYDGIPVVLEPEAEEVAGFFGSMLNSTHNVENPTFQ 293 Query: 342 SNFFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAE 500 NFF DF+A+L T AK I KCDF I + + ++ +KKA A+ A Sbjct: 294 KNFFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKPIFEYYDAKRLEKKAMSAAEKKAL 353 Query: 501 RKEAREAEA 527 + E AEA Sbjct: 354 KAEKDAAEA 362 [19][TOP] >UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR Length = 881 Score = 116 bits (291), Expect = 9e-25 Identities = 77/194 (39%), Positives = 103/194 (53%), Gaps = 20/194 (10%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRT-----LSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDG 161 K +R + K KTE ++ + G A +P+ E E + +RWWE K DG Sbjct: 188 KPVKRASTAKVKTEPKSAQSTPVKKGSAKATPVKKEESEEAEEAEEEEYRWWEDPTKGDG 247 Query: 162 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQ-TDHVLKE 332 +KWTTLEHNGV FPP YE P + Y+G+ ++L P AEEVA F+ S L T HV Sbjct: 248 TIKWTTLEHNGVVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNATQHVENP 307 Query: 333 KFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 491 F+ NFF DF+ +L D+K KV I KCDF I A+ + K+ EKK Sbjct: 308 TFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLP 363 Query: 492 TAERKEAR-EAEAE 530 AE+K + E +AE Sbjct: 364 PAEKKRLKAEKDAE 377 [20][TOP] >UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357 RepID=B8MY66_ASPFN Length = 881 Score = 116 bits (291), Expect = 9e-25 Identities = 77/194 (39%), Positives = 103/194 (53%), Gaps = 20/194 (10%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRT-----LSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDG 161 K +R + K KTE ++ + G A +P+ E E + +RWWE K DG Sbjct: 188 KPVKRASTAKVKTEPKSAQSTPVKKGSAKATPVKKEESEEAEEAEEEEYRWWEDPTKGDG 247 Query: 162 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQ-TDHVLKE 332 +KWTTLEHNGV FPP YE P + Y+G+ ++L P AEEVA F+ S L T HV Sbjct: 248 TIKWTTLEHNGVVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNATQHVENP 307 Query: 333 KFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 491 F+ NFF DF+ +L D+K KV I KCDF I A+ + K+ EKK Sbjct: 308 TFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLP 363 Query: 492 TAERKEAR-EAEAE 530 AE+K + E +AE Sbjct: 364 PAEKKRLKAEKDAE 377 [21][TOP] >UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans RepID=Q5KB99_CRYNE Length = 881 Score = 115 bits (287), Expect = 3e-24 Identities = 68/171 (39%), Positives = 89/171 (52%), Gaps = 4/171 (2%) Frame = +3 Query: 27 AGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFP 206 A GKAK G+ E E + ++WWE DG KWT LEHN V FP Sbjct: 214 ARGKAKAATVKEEKGKKTKKE---KEEEEEEERYKWWEQDALGDGSSKWTVLEHNAVLFP 270 Query: 207 PEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLA- 377 P Y P + Y+G+ L LPP +EEVA F+ + L+TD+ KFR NFF DF+A++ Sbjct: 271 PPYVPLPKNVKMKYDGVSLTLPPESEEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEK 330 Query: 378 -DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 K + LEKCDF + + E EK KKKA K + A + E + EA Sbjct: 331 YPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKALTKEEKKAIKAEKDKLEA 381 [22][TOP] >UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans RepID=O59891_CRYNE Length = 844 Score = 115 bits (287), Expect = 3e-24 Identities = 68/171 (39%), Positives = 89/171 (52%), Gaps = 4/171 (2%) Frame = +3 Query: 27 AGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFP 206 A GKAK G+ E E + ++WWE DG KWT LEHN V FP Sbjct: 177 ARGKAKAAQVKEEKGKKTKKE---KEEEEEEEKYKWWEQDALGDGSSKWTVLEHNAVLFP 233 Query: 207 PEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLA- 377 P Y P + Y+G+ L LPP +EEVA F+ + L+TD+ KFR NFF DF+A++ Sbjct: 234 PPYVPLPKDVKMKYDGVSLTLPPESEEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEK 293 Query: 378 -DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 K + LEKCDF + + E EK KKKA K + A + E + EA Sbjct: 294 YPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKALTKEEKKAIKAEKDKLEA 344 [23][TOP] >UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HAF8_AJECH Length = 909 Score = 115 bits (287), Expect = 3e-24 Identities = 72/187 (38%), Positives = 97/187 (51%), Gaps = 12/187 (6%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAA--GSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176 KV A++ KA+ D +AA EGE+ + +RWWE K DG +KWT Sbjct: 221 KVPAKKPSKAVKAEPADTKKMKAKAAVKNESSEELEGEDAEEEYRWWEDPAKGDGTIKWT 280 Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347 TLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L + H V F+ N Sbjct: 281 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 340 Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 FF DF A + ++ AK I S +KCDF I + E + +KK+ A+ + Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYEAARLEKKSLPSAEKKRLKA 400 Query: 507 EAREAEA 527 E E EA Sbjct: 401 EKDELEA 407 [24][TOP] >UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR RepID=C0NC53_AJECG Length = 909 Score = 115 bits (287), Expect = 3e-24 Identities = 72/187 (38%), Positives = 97/187 (51%), Gaps = 12/187 (6%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAA--GSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176 KV A++ KA+ D +AA EGE+ + +RWWE K DG +KWT Sbjct: 221 KVPAKKPSKAVKAEPADTKKMKAKAAVKNESSEELEGEDAEEEYRWWEDPAKGDGTIKWT 280 Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347 TLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L + H V F+ N Sbjct: 281 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 340 Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 FF DF A + ++ AK I S +KCDF I + E + +KK+ A+ + Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYEAARLEKKSLPSAEKKRLKA 400 Query: 507 EAREAEA 527 E E EA Sbjct: 401 EKDELEA 407 [25][TOP] >UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480 RepID=C5FTA8_NANOT Length = 896 Score = 114 bits (286), Expect = 4e-24 Identities = 74/184 (40%), Positives = 97/184 (52%), Gaps = 15/184 (8%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRTLSPG-----RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKW 173 KA + AG AKT T + + S AE E + +RWWE +K DG +KW Sbjct: 207 KAPAKKAGAAAKTTTATPAKKEKPSVKKEASEEVEAEEEEAEEEYRWWEDPSKGDGTIKW 266 Query: 174 TTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRS 344 TTLEHNGV FPP YE P + Y G+ + L P AEEVA+ + + L + H V F+ Sbjct: 267 TTLEHNGVVFPPPYEPLPKDVKMKYAGVPITLHPDAEEVASHFGTMLNSTHNVENPVFQK 326 Query: 345 NFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER 503 NFF DF+A++ T AK + KCDF I H E K +A+KKA T AE+ Sbjct: 327 NFFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVPIFEHHE----KLRAQKKAMTAAEK 382 Query: 504 KEAR 515 K A+ Sbjct: 383 KAAK 386 [26][TOP] >UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01 RepID=C1H484_PARBA Length = 900 Score = 114 bits (286), Expect = 4e-24 Identities = 76/186 (40%), Positives = 95/186 (51%), Gaps = 11/186 (5%) Frame = +3 Query: 3 KVKAERRVAG-GKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179 KVKAE A KAKT+ + A E E G+ +RWWE K DG +KWTT Sbjct: 219 KVKAESTDAKISKAKTKKESSEEADAD------VEAEEGEEEYRWWEDPTKGDGTIKWTT 272 Query: 180 LEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNF 350 LEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L + H V F+ NF Sbjct: 273 LEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKNF 332 Query: 351 FADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 F DF A + + AK I S +KCDF I E + +KKA A+ + E Sbjct: 333 FNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKPIFEFYEAARLEKKALPAAEKKRLKAE 392 Query: 510 AREAEA 527 E EA Sbjct: 393 KDELEA 398 [27][TOP] >UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus NAm1 RepID=A6R590_AJECN Length = 651 Score = 114 bits (286), Expect = 4e-24 Identities = 71/187 (37%), Positives = 97/187 (51%), Gaps = 12/187 (6%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAA--GSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176 KV A++ KA+ D + +AA E E+ + +RWWE K DG +KWT Sbjct: 221 KVPAKKTSKAVKAEPADTKKTKAKAAVKNESSEELEAEDAEEEYRWWEDPAKGDGTIKWT 280 Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347 TLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L + H V F+ N Sbjct: 281 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 340 Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 FF DF A + ++ AK + S EKCDF I + E + +KK+ A+ + Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIFEYYEAARLEKKSLPSAEKKRLKA 400 Query: 507 EAREAEA 527 E E EA Sbjct: 401 EKDELEA 407 [28][TOP] >UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP RepID=B2WCA4_PYRTR Length = 905 Score = 114 bits (284), Expect = 6e-24 Identities = 67/153 (43%), Positives = 82/153 (53%), Gaps = 10/153 (6%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275 E + + +RWW+ K DG KW TLEH GV FPPEYE P L+Y+G+ + L A Sbjct: 252 EAADEEDEYRWWDDPGKNDGTKKWDTLEHAGVVFPPEYEPLPKHVKLVYDGVPVTLHKDA 311 Query: 276 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431 EEVATFY S L + H V F NFF DF A+L T K I EKCDF Sbjct: 312 EEVATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKP 371 Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 I + E+AKKKA A+ A + E AEA+ Sbjct: 372 IFEWFDAERAKKKALSAAEKKALKAEKEAAEAD 404 [29][TOP] >UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HDT9_CHAGB Length = 907 Score = 112 bits (281), Expect = 1e-23 Identities = 69/168 (41%), Positives = 91/168 (54%), Gaps = 14/168 (8%) Frame = +3 Query: 63 SPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PH 224 +P G P+ EN +G +RWW+A K D VKWTTLEH+GV FPPEYE P Sbjct: 233 TPPDKGGKPVKDESKENSEGEDEEEYRWWDAPKKEDDSVKWTTLEHSGVLFPPEYERLPK 292 Query: 225 GFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-- 395 L+Y+G + L AEEVATF+ S L T +V F+ NFFADF+ +L T AK Sbjct: 293 NVKLLYDGQPVDLHIEAEEVATFFGSMLHSTQNVENPVFQKNFFADFKDILKKTGGAKDK 352 Query: 396 -----VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 I +K DF++I H + +KA A+ AE+ E +AE Sbjct: 353 QGKPVDIKEFKKLDFTKIFDHYKALGDARKARPAAEKKAEKAEKDKAE 400 [30][TOP] >UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732 RepID=C5DTC9_ZYGRC Length = 843 Score = 112 bits (280), Expect = 2e-23 Identities = 72/180 (40%), Positives = 97/180 (53%), Gaps = 8/180 (4%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 KVK E K+ED A + + A EN ++WWE K D VKWTTL Sbjct: 176 KVKEEEEEKEDSTKSED--------AEADVDAEAEEN----YKWWEK-EKDDDTVKWTTL 222 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 +HNGV FPP YEP + Y G + LPP AEEVA F+A+ LQ+DH F+SNFF Sbjct: 223 KHNGVIFPPTYEPLPSHIKMYYNGKPVDLPPQAEEVAGFFAALLQSDHAKNTVFQSNFFN 282 Query: 357 DFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK---AEKKAQTTAERKEARE 518 DF +L + TK I S +KCDF+++ E +K ++K ++K Q ER++ E Sbjct: 283 DFIEVLNENGGTKNGINIESFDKCDFTKMFEFFEMQKEQRKQLSPQEKKQLRMEREKFEE 342 [31][TOP] >UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JVY3_SCHJY Length = 654 Score = 112 bits (280), Expect = 2e-23 Identities = 64/160 (40%), Positives = 90/160 (56%), Gaps = 4/160 (2%) Frame = +3 Query: 72 RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYE 245 + +GS + + E +G F+WWE + DG+ KW TLEHNGV FPPEYEP ++Y Sbjct: 209 KMSGSIRSSPKTEEENGDFKWWET-DLPDGK-KWNTLEHNGVMFPPEYEPLPSHVKMLYN 266 Query: 246 GMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKC 419 G + LPPAAEEVA F+ + L++DH F+ NFF DF+A+ A K A + C Sbjct: 267 GKPIDLPPAAEEVAGFFGALLESDHAQNPTFQKNFFRDFQAVCKEAGMKSADIPKEFNSC 326 Query: 420 DFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVR 539 DF + + E K KK K + E K+ +E E E+ + Sbjct: 327 DFRPMFEYFESLKEAKKNMSK-EEKKELKKKKEEEEEKFK 365 [32][TOP] >UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FNH4_CANGA Length = 744 Score = 111 bits (277), Expect = 4e-23 Identities = 60/139 (43%), Positives = 81/139 (58%), Gaps = 8/139 (5%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE K D +KW +L+HNGV FPPEYEP L Y+G + LPPAAEEVA F+A Sbjct: 106 YKWWE-NEKNDDTIKWVSLKHNGVLFPPEYEPLPSHVKLYYDGKPVDLPPAAEEVAGFFA 164 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLE---DEKA 461 + L TDH F+ NFF DF +L + T+ IT +KCDFS++ + E +EK Sbjct: 165 NLLHTDHAKNPVFQKNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFELKKEEKR 224 Query: 462 KKKAEKKAQTTAERKEARE 518 E+K Q E+ + E Sbjct: 225 NMSREEKKQIKLEKDKFEE 243 [33][TOP] >UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii RepID=A5DLX4_PICGU Length = 754 Score = 111 bits (277), Expect = 4e-23 Identities = 67/179 (37%), Positives = 97/179 (54%), Gaps = 3/179 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K+ + K K E S + A + + + ++WWEA + DGE KW +L Sbjct: 78 KTKSNGKNGQEKVKKETSQTSDAQLATPTDSIKKEKEEEETYKWWEAQDM-DGEQKWESL 136 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 HNGV FPPEYEP + Y+G + L PAAEEVA F+A+ L+TDH F+ NF+ Sbjct: 137 HHNGVMFPPEYEPLPSHVKMYYDGKPVDLAPAAEEVAGFFAAMLETDHAQNPVFQKNFWN 196 Query: 357 DFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 DF ++ ++ A V + K DF+++ AH E K +KK + + A KEA+E E E Sbjct: 197 DFLQVVKESGGANVEMKDFTKADFTKMHAHFEMLKEQKKNMSRDEKKA-LKEAKEKEEE 254 [34][TOP] >UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL Length = 886 Score = 111 bits (277), Expect = 4e-23 Identities = 63/152 (41%), Positives = 84/152 (55%), Gaps = 10/152 (6%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275 EGE + +RWW+ K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A Sbjct: 233 EGEEEEEEYRWWDDPTKGDGTIKWTTLEHNGVVFPPPYEPLPQDVKMKYDGIPVTLHPEA 292 Query: 276 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431 EEVA F+ S L T HV F+ NFF+DF+ +L T AK I KCDF Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQS 352 Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 I A+ + ++ +K+ A+ + E AEA Sbjct: 353 IFAYYDAKRIEKRNIPPAEKKRLKAEKDAAEA 384 [35][TOP] >UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus RepID=UPI00017968A4 Length = 655 Score = 110 bits (276), Expect = 5e-23 Identities = 65/159 (40%), Positives = 90/159 (56%), Gaps = 2/159 (1%) Frame = +3 Query: 72 RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYE 245 R A +P G + E G +RWWE DG VKW LEH G YF P YEP G Y+ Sbjct: 77 RDAEAPKGQEKEEAGQ--WRWWEEEKSQDG-VKWKQLEHKGPYFAPSYEPLPDGVHFYYD 133 Query: 246 GMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDF 425 G + L AAEEVATFY L ++ KE F++NFF+D+R + + K+I L+KCDF Sbjct: 134 GKPVKLSLAAEEVATFYGKMLDHEYTTKEVFQNNFFSDWRKEMT-AEERKIIKHLDKCDF 192 Query: 426 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 + I + D+ A +KA + E K+ + EAE+++Q Sbjct: 193 TEIHRYFVDKTAARKA-----LSREEKQKLKEEAEKLQQ 226 [36][TOP] >UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis RepID=Q1DXZ1_COCIM Length = 905 Score = 110 bits (276), Expect = 5e-23 Identities = 66/145 (45%), Positives = 82/145 (56%), Gaps = 11/145 (7%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ Sbjct: 260 YRWWEEPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFG 319 Query: 300 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 455 S L + H V F+ NFF DF A++ T AK +I +KCDF I + E Sbjct: 320 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE-- 377 Query: 456 KAKKKAEKKAQTTAERKEAR-EAEA 527 K+ EKKA AERK + E EA Sbjct: 378 --MKREEKKALPAAERKRLKAEKEA 400 [37][TOP] >UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735 delta SOWgp RepID=C5P0Y8_COCP7 Length = 905 Score = 110 bits (276), Expect = 5e-23 Identities = 66/145 (45%), Positives = 82/145 (56%), Gaps = 11/145 (7%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ Sbjct: 260 YRWWEEPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFG 319 Query: 300 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 455 S L + H V F+ NFF DF A++ T AK +I +KCDF I + E Sbjct: 320 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE-- 377 Query: 456 KAKKKAEKKAQTTAERKEAR-EAEA 527 K+ EKKA AERK + E EA Sbjct: 378 --MKREEKKALPAAERKRLKVEKEA 400 [38][TOP] >UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC Length = 884 Score = 110 bits (276), Expect = 5e-23 Identities = 69/166 (41%), Positives = 91/166 (54%), Gaps = 17/166 (10%) Frame = +3 Query: 75 AAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPL 236 A +P+ E E + +RWWE K DG +KWTTLEHNGV FPP YE P + Sbjct: 218 AKSTPVKKEESEEAEDADEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKM 277 Query: 237 IYEGMELHLPPAAEEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK------ 395 Y+G+ + L P AEEVA F+ L T HV F+ NFF DFR +L T AK Sbjct: 278 KYDGIPVTLHPDAEEVAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNK 337 Query: 396 -VITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERKEAREA 521 I KCDF I A+ ++++ +KKA +K + AE K+A+EA Sbjct: 338 VDIKDFHKCDFQPIFAYYDNQRQEKKALPPAEKKRLKAE-KDAQEA 382 [39][TOP] >UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO Length = 732 Score = 110 bits (275), Expect = 7e-23 Identities = 63/179 (35%), Positives = 90/179 (50%), Gaps = 5/179 (2%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K ++RR K K E+ G + +GE F+WWE + D VKW TL Sbjct: 57 KTVSKRRAPARKVKEEE-----GDRDAKKESSVDGEEDSEEFKWWEREEEKDDSVKWVTL 111 Query: 183 EHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 HNGV FPPEY P L Y G + LP AEEVA F+A+ LQ+DH F+ NFF Sbjct: 112 RHNGVMFPPEYTPLPSHVRLYYGGKAVELPAEAEEVAGFFAALLQSDHAQNPVFQKNFFE 171 Query: 357 DFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 DF ++L A+ I KCDFS++ A+++ ++ + K + ++E + E Sbjct: 172 DFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQQRVQMKQLSSHERKLLKQEKGQTE 230 [40][TOP] >UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC Length = 998 Score = 110 bits (275), Expect = 7e-23 Identities = 65/154 (42%), Positives = 83/154 (53%), Gaps = 10/154 (6%) Frame = +3 Query: 96 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 269 A EGE + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P Sbjct: 343 AEEGEEEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHP 402 Query: 270 AAEEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDF 425 AEEVA F+ S L T HV F+ NFF DF+ +L T AK I KCDF Sbjct: 403 EAEEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDF 462 Query: 426 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 I + + ++ +KK A+ + E AEA Sbjct: 463 RPIFDYYDAKRIEKKNLPPAEKKRLKAEKDAAEA 496 [41][TOP] >UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4R0K7_MAGGR Length = 906 Score = 110 bits (275), Expect = 7e-23 Identities = 72/184 (39%), Positives = 90/184 (48%), Gaps = 10/184 (5%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188 K+ + A K K + + A + E E + +RWW+A K D +KW TLEH Sbjct: 219 KSAAKAAPAKGKAAAAKKTNAKQASEEVEGDEEEEEE--YRWWDAPKKEDDSIKWNTLEH 276 Query: 189 NGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFAD 359 NGV FPP+YE P L Y G+ L L P AEEVATF+ S L T +V F NFF Sbjct: 277 NGVLFPPDYEPLPKNVKLYYNGIPLQLHPEAEEVATFFGSMLHSTQNVENPTFIKNFFTG 336 Query: 360 FRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 F+ L T AK I EK DF I H + + KKA K + AE KEAR+ Sbjct: 337 FKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIFQHFQAQSEAKKARSKEEKKAE-KEARD 395 Query: 519 AEAE 530 E Sbjct: 396 KMEE 399 [42][TOP] >UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181 RepID=A1D4R5_NEOFI Length = 886 Score = 110 bits (275), Expect = 7e-23 Identities = 65/152 (42%), Positives = 82/152 (53%), Gaps = 10/152 (6%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275 EGE + +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A Sbjct: 233 EGEEEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHPEA 292 Query: 276 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431 EEVA F+ S L T HV F+ NFF DF+ +L T AK I KCDF Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRP 352 Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 I + E ++ +KK A+ + E AEA Sbjct: 353 IFDYYEAKRIEKKNLPPAEKKRLKAEKDAAEA 384 [43][TOP] >UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18 RepID=C1GKM6_PARBD Length = 825 Score = 110 bits (274), Expect = 9e-23 Identities = 64/152 (42%), Positives = 81/152 (53%), Gaps = 10/152 (6%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275 E E G+ +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A Sbjct: 252 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 311 Query: 276 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431 EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371 Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 I E + +KKA + + E E EA Sbjct: 372 IFEFYEAARLEKKALPATEKKRLKAEKDELEA 403 [44][TOP] >UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03 RepID=C0SEQ3_PARBP Length = 905 Score = 110 bits (274), Expect = 9e-23 Identities = 64/152 (42%), Positives = 81/152 (53%), Gaps = 10/152 (6%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275 E E G+ +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P A Sbjct: 252 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 311 Query: 276 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431 EEVA F+ S L + H V F+ NFF DF A + + AK I S +KCDF Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371 Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 I E + +KKA + + E E EA Sbjct: 372 IFEFYEAARLEKKALPATEKKRLKAEKDELEA 403 [45][TOP] >UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC 6260 RepID=UPI000151AE34 Length = 754 Score = 109 bits (273), Expect = 1e-22 Identities = 71/180 (39%), Positives = 99/180 (55%), Gaps = 4/180 (2%) Frame = +3 Query: 3 KVKAERRVAGGKAKTE-DRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179 K K + K K E +TL A + L E E + ++WWEA + DGE KW + Sbjct: 78 KTKLNGKNGQEKVKKETSQTLDAQLATPTDLIKKEKEEEET-YKWWEAQDM-DGEQKWES 135 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 L HNGV FPPEYEP + Y+G + L PAAEEVA F+A+ L+TDH F+ NF+ Sbjct: 136 LHHNGVMFPPEYEPLPSHVKMYYDGKPVDLAPAAEEVAGFFAAMLETDHAQNPVFQKNFW 195 Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 DF ++ ++ A V + K DF+++ AH E K +KK + + A KEA+E E E Sbjct: 196 NDFLQVVKESGGANVEMKDFTKADFTKMHAHFEMLKEQKKNMSRDEKKA-LKEAKEKEEE 254 [46][TOP] >UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina RepID=B2AY06_PODAN Length = 904 Score = 109 bits (273), Expect = 1e-22 Identities = 74/187 (39%), Positives = 95/187 (50%), Gaps = 12/187 (6%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAG--SPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176 KVK E A K K GR S +A E + +RWW+A K D +KWT Sbjct: 213 KVKKEAP-AKAKVKAAAAPAKKGRLVKEESVANSAADEEEEEEYRWWDAPKKEDDSIKWT 271 Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSN 347 TLEHNGV FPP YE P LIY+G ++L AEEVATF+ + L T +V F+ N Sbjct: 272 TLEHNGVLFPPAYEPLPKDVKLIYDGTPVNLHVDAEEVATFFGAMLHSTQNVENPTFQKN 331 Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 FF DFR +L +T AK I K DF++I + + KKA A+ AE+ Sbjct: 332 FFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIFEYYKGLSEAKKARPAAEKKAEKA 391 Query: 507 EAREAEA 527 E + EA Sbjct: 392 EKDKFEA 398 [47][TOP] >UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii CBS767 RepID=UPI00003BE191 Length = 789 Score = 109 bits (272), Expect = 1e-22 Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 3/183 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K + K + + P E E + ++WWEA + DGE KW +L Sbjct: 113 KSKGAKSTGSNKTDAVKKEDEVAKTEKDPSSTREDEEDEEKYKWWEAED-VDGEQKWESL 171 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EHNGV FPP+YEP L Y+G + LP AEEVA F+ + +TDH F+ NFF Sbjct: 172 EHNGVIFPPDYEPLPSHVKLYYDGKPVDLPLEAEEVAGFFGAMAETDHAKNPTFQKNFFE 231 Query: 357 DFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533 DF +L D V I + DFS++ AH E + +KK K + K+A +AE ++ Sbjct: 232 DFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAEKDK 286 Query: 534 VRQ 542 + Sbjct: 287 FEE 289 [48][TOP] >UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA Length = 789 Score = 109 bits (272), Expect = 1e-22 Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 3/183 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K + K + + P E E + ++WWEA + DGE KW +L Sbjct: 113 KSKGAKSTGSNKTDAVKKEDEVAKTEKDPSSTREDEEDEEKYKWWEAED-VDGEQKWESL 171 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EHNGV FPP+YEP L Y+G + LP AEEVA F+ + +TDH F+ NFF Sbjct: 172 EHNGVIFPPDYEPLPSHVKLYYDGKPVDLPLEAEEVAGFFGAMAETDHAKNPTFQKNFFE 231 Query: 357 DFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533 DF +L D V I + DFS++ AH E + +KK K + K+A +AE ++ Sbjct: 232 DFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAEKDK 286 Query: 534 VRQ 542 + Sbjct: 287 FEE 289 [49][TOP] >UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis RepID=C5GB81_AJEDR Length = 911 Score = 109 bits (272), Expect = 1e-22 Identities = 69/187 (36%), Positives = 94/187 (50%), Gaps = 12/187 (6%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAE--GENGDGGFRWWEAGNKTDGEVKWT 176 KV A++ V K++ D + A + E GE + +RWWE + DG +KWT Sbjct: 223 KVPAKKSVKAFKSEPADTKKGKAKVAMKKESSEELEGEEAEEEYRWWEDPAQGDGTIKWT 282 Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347 TLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L + H V F+ N Sbjct: 283 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 342 Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 FF DF A + + AK I S + CDF I + E + +KK A+ + Sbjct: 343 FFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKPIFEYYEAARLEKKNLPAAEKKRLKA 402 Query: 507 EAREAEA 527 E E EA Sbjct: 403 EKDELEA 409 [50][TOP] >UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis RepID=B9SSQ1_RICCO Length = 891 Score = 108 bits (271), Expect = 2e-22 Identities = 60/129 (46%), Positives = 77/129 (59%) Frame = +3 Query: 147 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326 + TDG+ KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A TD++ Sbjct: 340 SSTDGQKKWTTLIHNGVIFPPPYKPHGIKILYKGRPVDLAPEQEEVATMFAVMKDTDYMQ 399 Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 K KF NF+ D+R LL VI LE CDF+ I E EK EKK Q + E K Sbjct: 400 KPKFLENFWNDWRKLLGRN---HVIQKLEDCDFTPIYEWHEREK-----EKKKQMSTEEK 451 Query: 507 EAREAEAER 533 +A++ E R Sbjct: 452 KAQKEEKLR 460 [51][TOP] >UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEP3_LACTC Length = 756 Score = 108 bits (270), Expect = 3e-22 Identities = 68/186 (36%), Positives = 98/186 (52%), Gaps = 6/186 (3%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDG-GFRWWEAGNKTDGEVKWTT 179 K A +RVA K R S + P ++ D F+WWE N+ D +KWTT Sbjct: 76 KKSATKRVAKKAKKAVKREPSVEQQNAEPEEDSKELTEDADSFKWWEKENEDDS-IKWTT 134 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 L+HNGV FPP YEP L Y+G + LPP AEEVA F+A+ L++DH F+ NFF Sbjct: 135 LKHNGVIFPPPYEPLPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAQNPVFQKNFF 194 Query: 354 ADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 DF +L + K I E CDFS++ + + +K E+K Q +++ K+ + E Sbjct: 195 NDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQLQK-----EQKKQLSSQEKKKLKIE 249 Query: 525 AERVRQ 542 E+ + Sbjct: 250 KEQFEE 255 [52][TOP] >UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XZS7_CLAL4 Length = 764 Score = 108 bits (270), Expect = 3e-22 Identities = 62/144 (43%), Positives = 82/144 (56%), Gaps = 6/144 (4%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +W TLEHNGV FPP Y+P L Y+ ++LP AAEEVA F+A Sbjct: 128 YKWWEDEKFGEGPDRWQTLEHNGVIFPPPYKPLPSYVKLYYDSKPVNLPLAAEEVAGFFA 187 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 476 L+TDH F+ NFF DF +L + V IT +KCDFS++ AH K + E Sbjct: 188 EMLETDHAKNPVFQKNFFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF----VKVREE 243 Query: 477 KKAQTTAER---KEAREAEAERVR 539 KK + AE+ K+ REA E R Sbjct: 244 KKNMSKAEKLRLKQEREALEEPYR 267 [53][TOP] >UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU Length = 909 Score = 108 bits (270), Expect = 3e-22 Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 24/192 (12%) Frame = +3 Query: 18 RRVAGGKAKTEDRTLSPGRAAGSPLGAAEG---------ENGDGGFRWWEAGNKTDGEVK 170 +R + G K E + +P P A +G E+ + F WW A K D +K Sbjct: 209 KRKSNGVKKEESDSDAPISKKARPAAAKKGAKAESKKASESDEEEFEWWNAPKKEDDSIK 268 Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL---QTDHVLKEK 335 WTTLEHNGV FPP+YE P ++Y+G + L P EEVATF+ + + H+ Sbjct: 269 WTTLEHNGVLFPPDYEPLPKNVKMLYDGQPVTLAPEVEEVATFWVAMMTAASIHHLENPV 328 Query: 336 FRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKA 485 FR NFF DF+ + D + KV I SL+KC+F +I + +E K K +++ Sbjct: 329 FRKNFFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEK 388 Query: 486 QTTAERKEAREA 521 + +K+A EA Sbjct: 389 EAAKAKKDALEA 400 [54][TOP] >UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1 RepID=UPI000023DEFB Length = 910 Score = 108 bits (269), Expect = 3e-22 Identities = 64/187 (34%), Positives = 95/187 (50%), Gaps = 15/187 (8%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLE 185 VK E + + R + + A + A +G+ F WW A K D +KWTTLE Sbjct: 215 VKKEESDSDAPISKKVRPAAAKKGAKAESKKASESDGEEEFEWWNAPKKEDDSIKWTTLE 274 Query: 186 HNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL---QTDHVLKEKFRSNF 350 HNGV FPP+YE P ++Y+G + L P EEVATF+ + + H+ FR NF Sbjct: 275 HNGVLFPPDYEPLPKNVKMLYDGQPVTLAPEVEEVATFWVAMMTAASIHHLENPVFRKNF 334 Query: 351 FADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKAQTTAE 500 F DF+ + D + KV I SL+KC+F +I + +E K K +++ + Sbjct: 335 FDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEKEAAKA 394 Query: 501 RKEAREA 521 +K+A EA Sbjct: 395 KKDALEA 401 [55][TOP] >UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens RepID=A9T3W2_PHYPA Length = 632 Score = 108 bits (269), Expect = 3e-22 Identities = 55/118 (46%), Positives = 74/118 (62%) Frame = +3 Query: 165 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344 VKWTTLEHNGV FPP YEPHG ++Y+G + L PA EE+AT +A L+TD+ KE+F Sbjct: 89 VKWTTLEHNGVIFPPPYEPHGVKMLYDGKPVDLTPAQEEIATMFAVMLETDYAKKERFIK 148 Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 NF+ D++ L VI E CDF+ I D A++K KK+ +T E+K +E Sbjct: 149 NFWDDWKPYLGKN---HVIKKFELCDFTPI----FDWHAREKERKKSMSTEEKKRLKE 199 [56][TOP] >UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum RepID=Q9Y180_LEIIN Length = 635 Score = 107 bits (268), Expect = 4e-22 Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%) Frame = +3 Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 446 EVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL Sbjct: 82 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 139 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 539 E + ++ K EKKA KE ++AEAE R Sbjct: 140 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 165 [57][TOP] >UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani RepID=Q9NJG8_LEIDO Length = 949 Score = 107 bits (268), Expect = 4e-22 Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%) Frame = +3 Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E Sbjct: 337 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 396 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 446 EVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL Sbjct: 397 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 454 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 539 E + ++ K EKKA KE ++AEAE R Sbjct: 455 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 480 [58][TOP] >UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN Length = 635 Score = 107 bits (268), Expect = 4e-22 Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%) Frame = +3 Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 446 EVAT +A + D+ E FR NFF +R +L K I LE CDF I + HL Sbjct: 82 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 139 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 539 E + ++ K EKKA KE ++AEAE R Sbjct: 140 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 165 [59][TOP] >UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DTW1_TRYCR Length = 664 Score = 107 bits (268), Expect = 4e-22 Identities = 62/138 (44%), Positives = 77/138 (55%), Gaps = 4/138 (2%) Frame = +3 Query: 132 WWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS 302 WWE N T G+ +W TL HNGV FPPEY+PHG P+ YEG E L P EEVAT +A Sbjct: 33 WWEQENVQFTTKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAV 92 Query: 303 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEK 479 + D+ E FR NFF+ +R +L K I LE CDF I + HL ++ EK Sbjct: 93 MREHDYYRNEIFRRNFFSSWREIL--DKRQHPIRRLELCDFEPIYQWHL------REREK 144 Query: 480 KAQTTAERKEAREAEAER 533 K T E K+ EAE+ Sbjct: 145 KLSRTKEEKKQLRLEAEK 162 [60][TOP] >UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis RepID=A4HB62_LEIBR Length = 637 Score = 107 bits (268), Expect = 4e-22 Identities = 63/168 (37%), Positives = 86/168 (51%), Gaps = 4/168 (2%) Frame = +3 Query: 42 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPE 212 K EDR ++ R + EN + WWE N GE +W TL HNGV FPPE Sbjct: 2 KVEDRKMAVKREQSH--SNEDEENNEEDLNWWEQENLRIAMKGERRWETLSHNGVLFPPE 59 Query: 213 YEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFA 392 YEPHG + Y+G E + P EEVAT +A + D+ E FR NFF +R +L K Sbjct: 60 YEPHGISIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEAFRRNFFESWREIL--DKRQ 117 Query: 393 KVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533 I LE CDF I + +L + + K K+ + + + K+ +AE R Sbjct: 118 HPIRRLELCDFEPIYQWYLAEREKKLNRTKEEKKSIKEKQDMDAEPYR 165 [61][TOP] >UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI Length = 871 Score = 107 bits (268), Expect = 4e-22 Identities = 67/146 (45%), Positives = 84/146 (57%), Gaps = 14/146 (9%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ Sbjct: 226 YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285 Query: 300 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI----EAH 443 S L T H F+ NFFADF+ +L T AK I KCDF I +A Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQ 345 Query: 444 LEDEKAKKKAEKKAQTTAERKEAREA 521 +++KA AEKK + AE K+A+EA Sbjct: 346 RQEKKALPPAEKK-RLKAE-KDAQEA 369 [62][TOP] >UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CUT4_ASPTN Length = 872 Score = 107 bits (268), Expect = 4e-22 Identities = 70/189 (37%), Positives = 97/189 (51%), Gaps = 14/189 (7%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVK 170 KVK+E + A + + G A +P+ E + + +RWWE K+DG +K Sbjct: 188 KVKSEPKSA------QSTPVKKGSAKATPVKKEESADAEEAEEEEYRWWEDPTKSDGTIK 241 Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFR 341 WTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ S L T H F+ Sbjct: 242 WTTLEHNGVVFPPPYEPLPKNVKMKYDGVPVTLHPDAEEVAGFFGSMLNSTQHTENPTFQ 301 Query: 342 SNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAE 500 NFF DF+ +L D K KV I +KCDF I + E ++ +K+ A+ Sbjct: 302 KNFFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIFDYYEAKRIEKRNLPAAEKKRL 361 Query: 501 RKEAREAEA 527 + E E EA Sbjct: 362 KAEKDEQEA 370 [63][TOP] >UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2 Tax=Emericella nidulans RepID=C8VUK1_EMENI Length = 871 Score = 107 bits (268), Expect = 4e-22 Identities = 67/146 (45%), Positives = 84/146 (57%), Gaps = 14/146 (9%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ Sbjct: 226 YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285 Query: 300 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI----EAH 443 S L T H F+ NFFADF+ +L T AK I KCDF I +A Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQ 345 Query: 444 LEDEKAKKKAEKKAQTTAERKEAREA 521 +++KA AEKK + AE K+A+EA Sbjct: 346 RQEKKALPPAEKK-RLKAE-KDAQEA 369 [64][TOP] >UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR Length = 877 Score = 107 bits (267), Expect = 6e-22 Identities = 56/131 (42%), Positives = 79/131 (60%) Frame = +3 Query: 153 TDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332 +DG+ KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A TD+V K Sbjct: 329 SDGQKKWTTLVHNGVIFPPPYKPHGVKILYKGKPIDLTPEQEEVATMFAVMKDTDYVQKP 388 Query: 333 KFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512 +FR NF+ D+R LL VI L+ CDF+ I + EK K KK +T E+K Sbjct: 389 QFRQNFWNDWRKLLGKN---HVIQKLDDCDFNPIYEWHQQEKEK----KKQMSTEEKKVL 441 Query: 513 REAEAERVRQF 545 +E + ++ ++ Sbjct: 442 KEEKLKQEEKY 452 [65][TOP] >UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major RepID=Q4Q2K0_LEIMA Length = 634 Score = 107 bits (267), Expect = 6e-22 Identities = 62/147 (42%), Positives = 78/147 (53%), Gaps = 3/147 (2%) Frame = +3 Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 458 EVAT +A + D+ E FR NFF +R +L K I LE CDF I ++ Sbjct: 82 EVATMFAVMKEHDYYRMEVFRRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQR 139 Query: 459 AKKKAEKKAQTTAERKEAREAEAERVR 539 KK + K + A KE ++AEAE R Sbjct: 140 EKKLSRTKEEKKA-IKEKQDAEAEPYR 165 [66][TOP] >UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR Length = 664 Score = 107 bits (266), Expect = 7e-22 Identities = 61/138 (44%), Positives = 77/138 (55%), Gaps = 4/138 (2%) Frame = +3 Query: 132 WWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS 302 WWE N T G+ +W TL HNGV FPPEY+PHG P+ YEG E L P EEVAT +A Sbjct: 33 WWELENVQFSTKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAV 92 Query: 303 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEK 479 + D+ E FR NFF+ +R +L + I LE CDF I + HL ++ EK Sbjct: 93 MREHDYYRNEIFRRNFFSSWREIL--DRRQHPIRRLELCDFEPIYQWHL------REREK 144 Query: 480 KAQTTAERKEAREAEAER 533 K T E K+ EAE+ Sbjct: 145 KLSRTKEEKKQLRLEAEK 162 [67][TOP] >UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TJW1_VANPO Length = 799 Score = 107 bits (266), Expect = 7e-22 Identities = 56/139 (40%), Positives = 79/139 (56%), Gaps = 8/139 (5%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE N +GE++WTTL HNGV FPP Y P L Y G + LPP AEEVA F+A Sbjct: 161 YKWWE-DNDDNGEIQWTTLRHNGVMFPPPYVSLPSHIKLYYNGQAVDLPPTAEEVAGFFA 219 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLE---DEKA 461 + L TDH F+ NFF DF+ +L + T + E CDFS++ + E +++ Sbjct: 220 ALLHTDHAKNTVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEIQREQRK 279 Query: 462 KKKAEKKAQTTAERKEARE 518 K ++K Q E++E E Sbjct: 280 KLSPQEKKQLRLEKEEQEE 298 [68][TOP] >UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO Length = 910 Score = 106 bits (265), Expect = 1e-21 Identities = 54/126 (42%), Positives = 76/126 (60%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KW LEHNGV FPP Y+PHG ++Y+G + L P EEVAT +A L TD++ K +F+ N Sbjct: 365 KWNKLEHNGVIFPPPYKPHGIKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMNKPRFKEN 424 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 FF D++ +L VI +LE CDFS I + EK K KK TT E+K +E + Sbjct: 425 FFGDWKKILGKN---HVIQNLENCDFSPIYEWHQSEKEK----KKQMTTEEKKALKEEKL 477 Query: 528 ERVRQF 545 ++ ++ Sbjct: 478 KQEEKY 483 [69][TOP] >UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI Length = 857 Score = 106 bits (265), Expect = 1e-21 Identities = 55/117 (47%), Positives = 73/117 (62%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A L TD++ KEKF+ N Sbjct: 315 KWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMQKEKFKEN 374 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 F AD+R +L VI L+ CDF+ I ++EK K KK +T E+K +E Sbjct: 375 FMADWRKILGKN---HVIQRLDDCDFTPIYEWHQEEKEK----KKQMSTEEKKTLKE 424 [70][TOP] >UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6H1W4_PENCW Length = 864 Score = 106 bits (265), Expect = 1e-21 Identities = 68/185 (36%), Positives = 95/185 (51%), Gaps = 26/185 (14%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRTLSPGRAAGSPL------------GAAEGENGDGGFRWWEAGNK 152 K E + A K +T P + +P + E + +RWWE +K Sbjct: 167 KKEAKPAAAKKQTNGVKKEPAASKAAPKKGKAKVKEESQDAEEKDEEEEEEYRWWEDQSK 226 Query: 153 TDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-V 323 DG +KWTTLEHNGV FPPEYE P + Y+G+ + L P AEEVA+F+ + L + H V Sbjct: 227 GDGTIKWTTLEHNGVVFPPEYELLPQNVKMKYDGIPITLAPEAEEVASFFGTMLNSTHNV 286 Query: 324 LKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRI----EAHLEDEKAKKK 470 F+ NFF+DF+ ++ D+K KV I KCDF I +A E+++ Sbjct: 287 ENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIFEFYDAQREEKRHLPP 346 Query: 471 AEKKA 485 AEKKA Sbjct: 347 AEKKA 351 [71][TOP] >UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7Q9Y0_IXOSC Length = 499 Score = 106 bits (264), Expect = 1e-21 Identities = 67/180 (37%), Positives = 96/180 (53%), Gaps = 3/180 (1%) Frame = +3 Query: 6 VKAERRVAGGKAK-TEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 +K ++ KAK TE +T S A+ G A+ E ++WWE DG+ KW TL Sbjct: 176 IKPAKKSMPKKAKLTEVKTESEPTASKKKKGRAKKEEEVEVWKWWEEEKHDDGK-KWRTL 234 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP Y+ + L PAAEEVA FY L D+ KE F NFF Sbjct: 235 EHKGPVFAPPYEPLPDNVRFFYDNKVVKLSPAAEEVAGFYGRMLDHDYTSKEAFNKNFFK 294 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536 D+R + K A++IT L KC+F I+ + K+K+E++ + E K+A +A+ E++ Sbjct: 295 DWRKTMT-PKEAELITDLSKCNFKEIDVYY-----KQKSEERKAMSKEEKQAIKAQNEKL 348 [72][TOP] >UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=UPI0001760D92 Length = 748 Score = 105 bits (263), Expect = 2e-21 Identities = 59/141 (41%), Positives = 81/141 (57%), Gaps = 2/141 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE TDG KW LEH G FPP YEP Y+G + L PAAEEVATFYA Sbjct: 186 WKWWEEERYTDGS-KWRFLEHKGPVFPPPYEPLPGHIKFYYDGNAMKLSPAAEEVATFYA 244 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L+ ++ E FR NFF D+R + + +K IT L+KCDF+++ E K ++E Sbjct: 245 KMLEHEYTTNEIFRKNFFKDWRKEMTSEEKSK-ITELKKCDFTQMH-----EYFKAQSEA 298 Query: 480 KAQTTAERKEAREAEAERVRQ 542 + Q + E K+ + E ER+ Q Sbjct: 299 RKQMSKEEKQKNKEENERILQ 319 [73][TOP] >UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei RepID=Q581U8_9TRYP Length = 661 Score = 105 bits (262), Expect = 2e-21 Identities = 62/154 (40%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Frame = +3 Query: 90 LGAAEGENGDGGFRWWEAGNKTD---GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELH 260 L EG DG WW G T GE +W TL HNGV FPP Y PHG P++Y + Sbjct: 44 LANEEGGGNDGETEWWTQGTLTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFE 103 Query: 261 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-- 434 + P EEVAT +A + D+ E FR NFF +R +L K I LE CDFS I Sbjct: 104 MTPEEEEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYE 161 Query: 435 --EAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 + +E K++ + EKK E K + EAE Sbjct: 162 WHQREVEKRKSRTREEKK-----ELKRIADEEAE 190 [74][TOP] >UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma brucei RepID=C9ZLY6_TRYBG Length = 696 Score = 105 bits (262), Expect = 2e-21 Identities = 62/154 (40%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Frame = +3 Query: 90 LGAAEGENGDGGFRWWEAGNKTD---GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELH 260 L EG DG WW G T GE +W TL HNGV FPP Y PHG P++Y + Sbjct: 79 LANEEGGGNDGEAEWWTQGTLTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFE 138 Query: 261 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-- 434 + P EEVAT +A + D+ E FR NFF +R +L K I LE CDFS I Sbjct: 139 MTPEEEEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYE 196 Query: 435 --EAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 + +E K++ + EKK E K + EAE Sbjct: 197 WHQREVEKRKSRTREEKK-----ELKRIADEEAE 225 [75][TOP] >UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI Length = 871 Score = 105 bits (262), Expect = 2e-21 Identities = 65/146 (44%), Positives = 83/146 (56%), Gaps = 14/146 (9%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L P AEEVA F+ Sbjct: 226 YKWWEGPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285 Query: 300 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCD----FSRIEAH 443 S L T H F+ NFFADF+ +L T AK I KCD F +A Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIFQYYDAQ 345 Query: 444 LEDEKAKKKAEKKAQTTAERKEAREA 521 +++KA AEKK + AE K+A+EA Sbjct: 346 RQEKKALPPAEKK-RLKAE-KDAQEA 369 [76][TOP] >UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG Length = 763 Score = 105 bits (262), Expect = 2e-21 Identities = 56/136 (41%), Positives = 81/136 (59%), Gaps = 3/136 (2%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE N D E+KW +L+HNGV FPPE+ P L Y+ + LP AEEVA F+ Sbjct: 127 YKWWEENNDND-EIKWHSLKHNGVLFPPEHVPLPSHVKLYYDKKPVDLPIQAEEVACFFG 185 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 476 + L T+H F++NFF+DF+ ++ + A V I S +KCDFS+I H E +K+ KK+ Sbjct: 186 AMLNTEHAQNPAFQNNFFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQKSLKKSL 245 Query: 477 KKAQTTAERKEAREAE 524 AQ + E + E Sbjct: 246 TAAQKREIKSEKDKFE 261 [77][TOP] >UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66 RepID=B6ABX7_9CRYT Length = 660 Score = 105 bits (261), Expect = 3e-21 Identities = 50/133 (37%), Positives = 76/133 (57%) Frame = +3 Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308 +WWE K + ++W LEHNGV F P Y+ H PLIY+G E+ LP +EE+AT++A L Sbjct: 39 KWWERPAKDESSIQWDYLEHNGVMFAPPYQAHKVPLIYDGKEIELPNESEEIATYWAQIL 98 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 T+ KE+F N F + + + +KCDFS I+ H ++EK +KK K Q Sbjct: 99 DTEWSSKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEEKERKKNMNKEQ 158 Query: 489 TTAERKEAREAEA 527 +++ E+E+ Sbjct: 159 KEQQKRIKNESES 171 [78][TOP] >UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E5D8 Length = 961 Score = 104 bits (260), Expect = 4e-21 Identities = 64/151 (42%), Positives = 81/151 (53%), Gaps = 9/151 (5%) Frame = +3 Query: 84 SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMEL 257 SP + E ++WWE + DG+ KW LEH G F P YE P Y+G E+ Sbjct: 393 SPKKVKKEEEQQDVWKWWEEEKREDGK-KWKFLEHKGPLFAPLYERLPKSVKFFYDGKEI 451 Query: 258 HLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE 437 L AEEVATFYA L D+ KEKF +NFF D+R ++ D K KVIT L KC+F + Sbjct: 452 SLSEEAEEVATFYAKMLTHDYTTKEKFNTNFFNDWRKVMTD-KERKVITDLSKCNFKPMA 510 Query: 438 AHL----EDEKAKKKAEKKA---QTTAERKE 509 + E+ KA K EKK Q A +KE Sbjct: 511 LYFQEKSEERKAMSKEEKKVIKDQNDAIQKE 541 [79][TOP] >UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE Length = 2575 Score = 104 bits (260), Expect = 4e-21 Identities = 60/150 (40%), Positives = 83/150 (55%), Gaps = 2/150 (1%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 275 E E + RWWE DG+ KW TL H G FPP YEP G L+Y+G L P A Sbjct: 1847 EPEEEEEIHRWWEEEELPDGQ-KWRTLTHRGPLFPPAYEPLPKGVHLLYDGKPYLLKPEA 1905 Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 455 EE+A FYA L D+V K+ F NF D+RA + + K +T ++KCDFS I +H + Sbjct: 1906 EEIAGFYAMMLTRDYVHKDIFNENFMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQR 1964 Query: 456 KAKKKAEKKAQTTAERKEAREAEAERVRQF 545 +KA K E+++ +EAEA+ ++ Sbjct: 1965 AEARKAASK----EEKEKRKEAEAKLKEEY 1990 [80][TOP] >UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YQG7_NECH7 Length = 919 Score = 104 bits (260), Expect = 4e-21 Identities = 62/157 (39%), Positives = 83/157 (52%), Gaps = 15/157 (9%) Frame = +3 Query: 96 AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 269 A E + F WW K D +KW TLEHNGV FPPEYE P LIY+G ++L P Sbjct: 254 AKESGEEEEEFAWWLEPKKEDDSIKWNTLEHNGVLFPPEYEPMPKHIKLIYDGKPVNLAP 313 Query: 270 AAEEVATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCD 422 EEVATF+ + + + H+ FR NFF DF+ + D KV I SL+KCD Sbjct: 314 EVEEVATFWVAMMTPASSHHMENPVFRKNFFEDFQEYCKKYGVTDADGKKVQIKSLDKCD 373 Query: 423 FSRIE----AHLEDEKAKKKAEKKAQTTAERKEAREA 521 F+++ A E K K +++ + +KEA EA Sbjct: 374 FTKLADYWLAKAEQNKTKNMTKEEKEAAKAKKEALEA 410 [81][TOP] >UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JVV4_UNCRE Length = 889 Score = 104 bits (260), Expect = 4e-21 Identities = 62/140 (44%), Positives = 77/140 (55%), Gaps = 10/140 (7%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG +KWTTLEHNGV FPP YE P + Y+G+ + L AEEVA F+ Sbjct: 262 YRWWEDPAKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPITLSLEAEEVAGFFG 321 Query: 300 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 455 S L + H V F+ NFF DF A++ T AK I +KCDF I + E Sbjct: 322 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIFEYYE-- 379 Query: 456 KAKKKAEKKAQTTAERKEAR 515 K+ EKKA AERK + Sbjct: 380 --MKRLEKKALPAAERKRLK 397 [82][TOP] >UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major RepID=Q7YXA0_LEIMA Length = 200 Score = 104 bits (259), Expect = 5e-21 Identities = 61/147 (41%), Positives = 77/147 (52%), Gaps = 3/147 (2%) Frame = +3 Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 E + WWE N GE +W TL HNGV FPPEYEPHG P+ Y+G E + P E Sbjct: 22 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 458 EVAT +A + D+ E F NFF +R +L K I LE CDF I ++ Sbjct: 82 EVATMFAVMKEHDYYRMEVFWRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQR 139 Query: 459 AKKKAEKKAQTTAERKEAREAEAERVR 539 KK + K + A KE ++AEAE R Sbjct: 140 EKKLSRTKEEKEA-IKEKQDAEAEPYR 165 [83][TOP] >UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA topoisomerase I n=1 Tax=Candida glabrata RepID=Q6FVE9_CANGA Length = 717 Score = 104 bits (259), Expect = 5e-21 Identities = 60/135 (44%), Positives = 78/135 (57%), Gaps = 5/135 (3%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +K D +KWTTLEHNGV FPP YE P L YEG + LP AEEVA F+A Sbjct: 79 YKWWEEQDKDD-TIKWTTLEHNGVLFPPPYEALPSHVKLYYEGNPVDLPLEAEEVAGFFA 137 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK 470 L+T H F+ NFF DF+ +L D T+ I S ++ DFS + D + K Sbjct: 138 HLLETPHAQNPVFQKNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHDYFVQLK 193 Query: 471 AEKKAQTTAERKEAR 515 EKK+ T ++KE R Sbjct: 194 EEKKSMTAMQKKEIR 208 [84][TOP] >UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH Length = 916 Score = 104 bits (259), Expect = 5e-21 Identities = 56/131 (42%), Positives = 80/131 (61%), Gaps = 1/131 (0%) Frame = +3 Query: 156 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335 DG+ KWTTL HNGV FPP Y+PHG ++Y+G + L EEVAT +A +TD+ K + Sbjct: 366 DGQKKWTTLVHNGVIFPPPYKPHGIKILYKGKPVDLTIEQEEVATMFAVMRETDYYTKPQ 425 Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEA 512 FR NF+ D+R LL VI L+ CDF+ I E HLE+ K +KK +T E+K Sbjct: 426 FRENFWNDWRRLLGK---KHVIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKAL 477 Query: 513 REAEAERVRQF 545 +E + ++ ++ Sbjct: 478 KEEKMKQEEKY 488 [85][TOP] >UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra magnipapillata RepID=UPI000192545C Length = 726 Score = 103 bits (258), Expect = 6e-21 Identities = 68/182 (37%), Positives = 91/182 (50%), Gaps = 13/182 (7%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDR-----------TLSPGRAAGSPLGAAEGENGDGGFRWWEAGNK 152 +KA+ +V G K K E+ T S + P + E + +RWW+ Sbjct: 102 LKAKVKVEGRKRKNENNDFEDVKKNKNSTQSKNQNKEKPKKVKKEEEEEV-WRWWDEDPH 160 Query: 153 TDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326 DG +KW TL H G YFPPEYEP Y+G + L AEEVATFYA L D+V Sbjct: 161 QDG-IKWKTLSHEGPYFPPEYEPMPKNVKFYYDGKPMQLSLEAEEVATFYAKMLDHDYVK 219 Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 K+ F NFF D+R + + +I SL+KCDF + A+ K AE+K T E K Sbjct: 220 KDIFNENFFEDWRKEMT-AEERNIIKSLDKCDFKEMHAYF-----MKCAEEKRNMTKEEK 273 Query: 507 EA 512 +A Sbjct: 274 QA 275 [86][TOP] >UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri RepID=Q00XV7_OSTTA Length = 783 Score = 103 bits (258), Expect = 6e-21 Identities = 56/133 (42%), Positives = 78/133 (58%), Gaps = 9/133 (6%) Frame = +3 Query: 147 NKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308 N+++G VK W TLEHNGV FPP YEPHG PL Y+G ++ L P EE+A F+A Sbjct: 223 NRSEGYVKKGAVIMWKTLEHNGVVFPPPYEPHGVPLTYDGQDVKLLPHEEEIAGFFAVMK 282 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAH---LEDEKAKKKAEK 479 TD+ K F NF F+ LA+ A IT KCDF+++ H + +EK + +E+ Sbjct: 283 DTDYAQKAVFVKNFMDGFKEALANGPHA-FITDFRKCDFTKMYNHFAKIREEKKQMTSEE 341 Query: 480 KAQTTAERKEARE 518 K + AE+ +A E Sbjct: 342 KKRIKAEKDKAEE 354 [87][TOP] >UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays RepID=B7ZWU7_MAIZE Length = 574 Score = 103 bits (258), Expect = 6e-21 Identities = 56/130 (43%), Positives = 75/130 (57%), Gaps = 1/130 (0%) Frame = +3 Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338 G KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K F Sbjct: 28 GGKKWTTLEHNGVIFPPPYKPHGVKMLYNGKPIDLTPEQEEVATMFAVMKDTDYAAKPTF 87 Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515 NFF D+R +L +I + E CDF+ I E HL ++K KK TT E+K R Sbjct: 88 IDNFFTDWRKVLGKN---HIIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLR 139 Query: 516 EAEAERVRQF 545 E + ++ ++ Sbjct: 140 EDKLKQEEKY 149 [88][TOP] >UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA Length = 785 Score = 103 bits (258), Expect = 6e-21 Identities = 57/136 (41%), Positives = 80/136 (58%), Gaps = 8/136 (5%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 F+WWE G+K D +KWTTL+HNGV FP YE P L Y G + LPP AEEVA F+A Sbjct: 146 FKWWENGDKEDDTIKWTTLKHNGVIFPSTYEPLPAHVKLYYNGKPVDLPPQAEEVAGFFA 205 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKK 470 + L++DHV F+ NF DF +L + A+ I K DF++I + + +K +KK Sbjct: 206 AILESDHVKIPTFQKNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQVQKEQKK 265 Query: 471 ---AEKKAQTTAERKE 509 ++K Q E++E Sbjct: 266 QLSPQEKKQLRLEKEE 281 [89][TOP] >UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana B05.10 RepID=A6S3Q9_BOTFB Length = 912 Score = 103 bits (258), Expect = 6e-21 Identities = 66/183 (36%), Positives = 88/183 (48%), Gaps = 10/183 (5%) Frame = +3 Query: 9 KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188 KA + GK K E T + E E D +RWW+A K D +KW TL+H Sbjct: 231 KAAPKKVNGKVKAEPDTKVKAKKD-------ESEEADEVYRWWDAPKKEDDSIKWETLQH 283 Query: 189 NGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNFFAD 359 NGV FPPEYE P L Y+G+ L L +EE+A F+ + L + H V F+ NFF D Sbjct: 284 NGVVFPPEYEPLPKNVKLRYDGIPLTLSLESEEIAGFFGAMLNSTHNVENPTFQKNFFKD 343 Query: 360 FRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 F + T AK I K DF I + + + ++KA A+ AE+ E Sbjct: 344 FTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIFEYYDGKSTERKARSAAEKKAEKALKDE 403 Query: 519 AEA 527 AEA Sbjct: 404 AEA 406 [90][TOP] >UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio RepID=Q6T721_DANRE Length = 600 Score = 103 bits (257), Expect = 8e-21 Identities = 56/138 (40%), Positives = 79/138 (57%), Gaps = 2/138 (1%) Frame = +3 Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308 WE G D VKW++LEH G YF P+YEP Y+G ++ L P EE+ATFYA L Sbjct: 42 WEEGKSCDA-VKWSSLEHKGPYFAPDYEPLPANICFYYDGQQVKLSPLTEEIATFYAKML 100 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 ++ KE F+ NFF D+R + + K+IT+L KCDF+ I + + KAE+K Sbjct: 101 DHEYTTKEVFQKNFFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE-----KAEEKKN 154 Query: 489 TTAERKEAREAEAERVRQ 542 T E K+ + EA R+ + Sbjct: 155 MTKEEKQVLKDEAARLME 172 [91][TOP] >UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE Length = 904 Score = 103 bits (256), Expect = 1e-20 Identities = 56/130 (43%), Positives = 74/130 (56%), Gaps = 1/130 (0%) Frame = +3 Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338 G KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K F Sbjct: 358 GGKKWTTLEHNGVIFPPPYKPHGVKMLYNGKPVDLTPEQEEVATMFAVMKDTDYAAKPTF 417 Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515 NFF D+R +L +I + E CDF+ I E HL ++K KK TT E+K R Sbjct: 418 IDNFFTDWRKVLGKN---HIIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLR 469 Query: 516 EAEAERVRQF 545 E ++ ++ Sbjct: 470 EDNLKQEEKY 479 [92][TOP] >UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa RepID=B9I1A0_POPTR Length = 860 Score = 103 bits (256), Expect = 1e-20 Identities = 56/132 (42%), Positives = 78/132 (59%), Gaps = 1/132 (0%) Frame = +3 Query: 153 TDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332 +DG+ KW TL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A T++V K Sbjct: 312 SDGQKKWKTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMKDTEYVQKP 371 Query: 333 KFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKE 509 +F NF+ D+R LL VI LE CDF+ I E H K+K +KK +T E+K Sbjct: 372 QFLQNFWNDWRTLLGKN---HVIQKLEACDFNPIYEWH-----QKEKEKKKQMSTEEKKA 423 Query: 510 AREAEAERVRQF 545 RE + ++ + Sbjct: 424 VREEKLKQEEMY 435 [93][TOP] >UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT Length = 926 Score = 103 bits (256), Expect = 1e-20 Identities = 54/119 (45%), Positives = 72/119 (60%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV FPP Y+PHG ++Y+ L L P EEVAT +A+ L TD++ K +F+ N Sbjct: 382 KWTTLVHNGVMFPPPYKPHGVKMLYKRQPLTLTPEQEEVATMFAAMLDTDYMNKPRFKEN 441 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 FF+D++ +L I +LE CDF I + EK EKK Q T E K+A + E Sbjct: 442 FFSDWKKILGKN---HTIQNLEDCDFGPIYEWHQQEK-----EKKKQMTTEEKKALKEE 492 [94][TOP] >UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens RepID=TOP1M_HUMAN Length = 601 Score = 103 bits (256), Expect = 1e-20 Identities = 63/152 (41%), Positives = 83/152 (54%), Gaps = 2/152 (1%) Frame = +3 Query: 93 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLP 266 G+ + G G WE DG VKW LEH G YF P YEP G YEG + L Sbjct: 30 GSRRTQKGSGAR--WEKEKHEDG-VKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLS 86 Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446 AAEEVATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + Sbjct: 87 VAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYF 145 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 D+ A +K + E K+ + EAE+++Q Sbjct: 146 VDKAAARKV-----LSREEKQKLKEEAEKLQQ 172 [95][TOP] >UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1 Tax=Tribolium castaneum RepID=UPI00017582B6 Length = 936 Score = 102 bits (255), Expect = 1e-20 Identities = 54/133 (40%), Positives = 80/133 (60%), Gaps = 4/133 (3%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE K DG+ KW LEH G F P YEP Y+G E+ L P AEEVA+FY+ Sbjct: 376 WKWWEEEKKDDGK-KWKFLEHKGPVFAPPYEPLPDHVKFYYDGKEMKLTPEAEEVASFYS 434 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED--EKAKKKA 473 L D+ KE F +NFF D+R ++++++ KVI L+KC+F + A+ D EK + + Sbjct: 435 KMLDHDYTTKEVFNNNFFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMDLAEKNRNRT 493 Query: 474 EKKAQTTAERKEA 512 +++ Q E+ EA Sbjct: 494 KEEKQALKEKNEA 506 [96][TOP] >UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum bicolor RepID=C5YGY1_SORBI Length = 921 Score = 102 bits (255), Expect = 1e-20 Identities = 55/127 (43%), Positives = 74/127 (58%), Gaps = 1/127 (0%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K F N Sbjct: 378 KWTTLEHNGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYAGKPTFIDN 437 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 FF D+R +L +I E CDF+ I E HL ++K +KK TT E+K RE + Sbjct: 438 FFTDWRKILGKN---HIIKKFELCDFTPIYEWHL-----REKEKKKQMTTEEKKALREEK 489 Query: 525 AERVRQF 545 ++ ++ Sbjct: 490 LKQEEKY 496 [97][TOP] >UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7EXF7_SCLS1 Length = 911 Score = 102 bits (255), Expect = 1e-20 Identities = 67/185 (36%), Positives = 87/185 (47%), Gaps = 10/185 (5%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 KVK E KAK E E E D +RWW+A K D +KW TL Sbjct: 238 KVKPEPDTKKAKAKKE-----------------ESEEADEVYRWWDAPKKEDDSIKWETL 280 Query: 183 EHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNFF 353 +HNGV FPPEYE P L Y+G+ L L +EE+A F+ + L + H V F+ NFF Sbjct: 281 QHNGVVFPPEYEPLPKNVKLGYDGIPLTLSLESEEIAGFFGAMLNSTHNVENPTFQKNFF 340 Query: 354 ADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512 DF + T AK I K DF I + + + ++KA A+ AE+ Sbjct: 341 KDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIFEYYDGKSTERKARSAAEKKAEKAAK 400 Query: 513 REAEA 527 EAEA Sbjct: 401 DEAEA 405 [98][TOP] >UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC Length = 894 Score = 102 bits (253), Expect = 2e-20 Identities = 55/120 (45%), Positives = 71/120 (59%), Gaps = 3/120 (2%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KW TL HNGV FPP Y+PHG ++Y+G + L P EEVAT +A L TD++ K KF+ N Sbjct: 351 KWNTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKSKFKEN 410 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK---AEKKAQTTAERKEARE 518 F D+R +L VI +LE CDF+ I + EK KKK AE+K ER + E Sbjct: 411 FMDDWRKILGKN---HVIQNLEDCDFTPIYEWHQREKEKKKKMTAEEKKVLKEERLKQEE 467 [99][TOP] >UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera RepID=UPI0000DB758E Length = 973 Score = 101 bits (252), Expect = 3e-20 Identities = 55/142 (38%), Positives = 78/142 (54%), Gaps = 2/142 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE K DG KWT LEH G F P YEP Y G E+ L EEVATFYA Sbjct: 429 WKWWEEEKKNDG-TKWTFLEHKGPVFAPPYEPLPPDVNFYYNGKEMKLSQDTEEVATFYA 487 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ K F SNFF D+R ++ +++ K++ L KC+F I A+ +K E+ Sbjct: 488 RMLDHDYTTKPAFNSNFFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----IQKSEER 542 Query: 480 KAQTTAERKEAREAEAERVRQF 545 KA T E+++ +E E +++ Sbjct: 543 KAMTKEEKQKIKEKNEEIQKEY 564 [100][TOP] >UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT Length = 927 Score = 101 bits (252), Expect = 3e-20 Identities = 52/126 (41%), Positives = 74/126 (58%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV FPP Y PHG ++Y+ + L P EEVAT +A L TD++ K +F+ N Sbjct: 383 KWTTLVHNGVIFPPPYNPHGVKMLYKRQPITLTPEQEEVATMFAVMLDTDYMNKPRFKEN 442 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 FF+D++ +L I +LE CDF I + EK K KK TT E+K +E + Sbjct: 443 FFSDWKKMLGKN---HTIQNLEDCDFGPIYEWHQQEKEK----KKQMTTEEKKALKEDKL 495 Query: 528 ERVRQF 545 ++ ++ Sbjct: 496 QQEEKY 501 [101][TOP] >UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA Length = 829 Score = 101 bits (252), Expect = 3e-20 Identities = 65/188 (34%), Positives = 97/188 (51%), Gaps = 8/188 (4%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSP---GRAAGSPLGAAEGE---NGDGGFRWWEAGNKTDGE 164 K+K+E G K K E+ + P +A G+ G + + + ++WWE DG Sbjct: 212 KIKSEDDKKGKKRKQEEEDIKPKKKSKAKGNEEGVKKKKVKKEEEEKWKWWEEERHRDG- 270 Query: 165 VKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338 +KW LEH G F P YEP Y+G + L P AEEVATF+A L ++ K+ F Sbjct: 271 IKWKFLEHKGPVFAPPYEPVPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIF 330 Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 R NFF D++ + T +IT+L KCDF+ + + K+++E + T E K + Sbjct: 331 RKNFFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF-----KEQSEARKNMTKEEKLKIK 384 Query: 519 AEAERVRQ 542 AE ER+ Q Sbjct: 385 AENERLLQ 392 [102][TOP] >UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes RepID=TOP1M_PANTR Length = 601 Score = 101 bits (251), Expect = 4e-20 Identities = 60/148 (40%), Positives = 80/148 (54%), Gaps = 2/148 (1%) Frame = +3 Query: 93 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLP 266 G+ + G G WE DG VKW LEH G YF P YEP G YEG + L Sbjct: 30 GSRRTQKGSGAR--WEKEKHEDG-VKWRQLEHKGPYFAPPYEPLPDGVRFFYEGKPVRLS 86 Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446 AAEEVATFY L ++ KE FR NFF D+R +A + +VI SL+KCDF+ I + Sbjct: 87 VAAEEVATFYGRMLGHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYF 145 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAE 530 D+ A +K + + ++EA + + E Sbjct: 146 VDKAAARKVLSREEKQKLKEEAEKLQRE 173 [103][TOP] >UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia vitripennis RepID=UPI00015B4D8F Length = 1019 Score = 100 bits (250), Expect = 5e-20 Identities = 58/140 (41%), Positives = 77/140 (55%), Gaps = 6/140 (4%) Frame = +3 Query: 84 SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMEL 257 SP + E ++WWE K DG KW LEH G F PEYEP Y G E+ Sbjct: 445 SPKKKKKEEEEPEVWKWWEEEKKNDG-TKWHFLEHKGPVFAPEYEPLPPSVKFYYNGKEM 503 Query: 258 HLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE 437 L EEVATFYA L+ D+ K+ F NFF D+R ++ +++ AK IT L+KC+F+ + Sbjct: 504 KLTQDTEEVATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAK-ITDLKKCNFTEMH 562 Query: 438 AHL----EDEKAKKKAEKKA 485 + E+ KA K EKKA Sbjct: 563 KYFIMKSEERKAMSKEEKKA 582 [104][TOP] >UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA Length = 763 Score = 100 bits (250), Expect = 5e-20 Identities = 61/174 (35%), Positives = 95/174 (54%), Gaps = 3/174 (1%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLE 185 +K E+++ K K++++ L+ ++ E D ++WWE + DG +KW TLE Sbjct: 91 IKTEKKLKK-KHKSQEKELNSEELKNEESLRSKEEEED--YKWWEQ-QQGDGTIKWKTLE 146 Query: 186 HNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE-KFRSNFFA 356 HNGV FPP YE P + Y+G + LPP AEEVA F+ + L ++ +K F+ NFF Sbjct: 147 HNGVLFPPPYEPLPSYVKMKYKGEPISLPPEAEEVAGFFGAILSSEQYVKNPTFQKNFFH 206 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 DF+ T + E CDF+ + + E KKK EKK ++ E+K+ +E Sbjct: 207 DFQETCKKTNAPVIPEKFEYCDFTPMFEYFE----KKKEEKKNKSKEEKKKIKE 256 [105][TOP] >UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC Length = 852 Score = 100 bits (249), Expect = 7e-20 Identities = 54/125 (43%), Positives = 75/125 (60%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV FPP Y+PHG ++Y+G + L P EEVAT YA L TD++ K +F+ N Sbjct: 334 KWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMSKLQFKEN 393 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 F D+R +L VI +L+ CDF+ I E+ + EKK Q + +RK R Sbjct: 394 FMNDWRKILGKN---HVIQNLDDCDFTPIY-----ERPSSEKEKKKQMSTKRK--RPLRE 443 Query: 528 ERVRQ 542 E+++Q Sbjct: 444 EKLKQ 448 [106][TOP] >UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO Length = 1043 Score = 100 bits (249), Expect = 7e-20 Identities = 62/172 (36%), Positives = 84/172 (48%), Gaps = 2/172 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 KVK E + K E SP + + E E +RWWE + DG VKWTTL Sbjct: 451 KVKKESEI-----KQEPSQTSPTKRSRKDKKEEEEEV----WRWWEEEKREDG-VKWTTL 500 Query: 183 EHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YE P Y+G + L EE ATFYA L D+ K+ F +NFF Sbjct: 501 EHKGPVFAPPYERVPRNVRFFYDGKPMELSEETEEAATFYAKMLNHDYCTKDVFNNNFFK 560 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512 DFR + K ++I KC+F + + + E K+KA K + A++ E+ Sbjct: 561 DFRKTMT-PKEKEIIKDFRKCNFQEMFEYFQAESEKRKAATKEEKLAKKVES 611 [107][TOP] >UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN Length = 990 Score = 100 bits (249), Expect = 7e-20 Identities = 52/130 (40%), Positives = 71/130 (54%), Gaps = 2/130 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE + DG VKW+TLEH G F P YE P Y+G L L EE ATFYA Sbjct: 444 WRWWEEEKREDG-VKWSTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAATFYA 502 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ K+ F +NFF DFR + +K ++I KC+F + + + E K+KA Sbjct: 503 KMLNHDYCTKDVFNTNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEKRKAAT 561 Query: 480 KAQTTAERKE 509 K + A++ E Sbjct: 562 KEEKLAKKNE 571 [108][TOP] >UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera RepID=UPI000198447D Length = 883 Score = 100 bits (248), Expect = 9e-20 Identities = 57/126 (45%), Positives = 70/126 (55%) Frame = +3 Query: 147 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326 N +G+ KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ Sbjct: 334 NSGEGQ-KWTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYAT 392 Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 K +F NF D+R L VI E CDF+ I E EK EKK Q T E K Sbjct: 393 KPRFIENFMNDWRVRLGKN---HVIKKFELCDFTPIYEWHEKEK-----EKKKQMTTEEK 444 Query: 507 EAREAE 524 +A + E Sbjct: 445 KALKEE 450 [109][TOP] >UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE Length = 469 Score = 100 bits (248), Expect = 9e-20 Identities = 70/182 (38%), Positives = 96/182 (52%), Gaps = 2/182 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K E K KT+D+ G A A+ E + ++WWE TDG VKW L Sbjct: 159 KRKQEEEDIKPKKKTKDKK---GEVATDGKKKAKKEPEEK-WKWWEEERYTDG-VKWKFL 213 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP Y+G + L P AEEVATF++ L ++ K+ FR NFF Sbjct: 214 EHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFRKNFFK 273 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536 D+R + + +K IT L KCDFS + + KA+ +A +KA T E+ + +E E ER+ Sbjct: 274 DWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKE-ENERI 327 Query: 537 RQ 542 Q Sbjct: 328 LQ 329 [110][TOP] >UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE Length = 758 Score = 100 bits (248), Expect = 9e-20 Identities = 70/182 (38%), Positives = 96/182 (52%), Gaps = 2/182 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K E K KT+D+ G A A+ E + ++WWE TDG VKW L Sbjct: 159 KRKQEEEDIKPKKKTKDKK---GEVATDGKKKAKKEPEEK-WKWWEEERYTDG-VKWKFL 213 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP Y+G + L P AEEVATF++ L ++ K+ FR NFF Sbjct: 214 EHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFRKNFFK 273 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536 D+R + + +K IT L KCDFS + + KA+ +A +KA T E+ + +E E ER+ Sbjct: 274 DWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKE-ENERI 327 Query: 537 RQ 542 Q Sbjct: 328 LQ 329 [111][TOP] >UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1 Tax=Vitis vinifera RepID=A7PX10_VITVI Length = 789 Score = 100 bits (248), Expect = 9e-20 Identities = 57/126 (45%), Positives = 70/126 (55%) Frame = +3 Query: 147 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326 N +G+ KWTTLEHNGV FPP Y+PHG ++Y G + L P EEVAT +A TD+ Sbjct: 240 NSGEGQ-KWTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYAT 298 Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 K +F NF D+R L VI E CDF+ I E EK EKK Q T E K Sbjct: 299 KPRFIENFMNDWRVRLGKN---HVIKKFELCDFTPIYEWHEKEK-----EKKKQMTTEEK 350 Query: 507 EAREAE 524 +A + E Sbjct: 351 KALKEE 356 [112][TOP] >UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster RepID=Q494M1_DROME Length = 974 Score = 100 bits (248), Expect = 9e-20 Identities = 57/158 (36%), Positives = 79/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 42 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 218 K + +SPG+ + E E +RWWE + DG VKW+TLEH G F P YE Sbjct: 404 KEPEPAVSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 458 Query: 219 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395 P Y+G L L EE ATFYA L D+ KE F +NFF DFR + + + Sbjct: 459 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 517 Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 +I KC+F + + + E K+KA K + ++ E Sbjct: 518 IIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 555 [113][TOP] >UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura RepID=B5DMS2_DROPS Length = 1054 Score = 100 bits (248), Expect = 9e-20 Identities = 59/174 (33%), Positives = 89/174 (51%), Gaps = 2/174 (1%) Frame = +3 Query: 15 ERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNG 194 ++++ ++ + +SP + G+ E + +RWWE + DG VKW+TLEH G Sbjct: 463 KKKIKKESSEIKTEVVSPTKRKGAK------EEEEEVWRWWEEEKREDG-VKWSTLEHKG 515 Query: 195 VYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRA 368 F P YE P Y+G L L EE ATFYA L D+ K+ F +NFF DFR Sbjct: 516 PVFAPPYERVPRNVRFFYDGRPLDLSEETEEAATFYAKMLNHDYCTKDIFNNNFFKDFRK 575 Query: 369 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 + +K ++I KC+F + + + E +EK+ Q T E K A++ E E Sbjct: 576 SMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNENE 623 [114][TOP] >UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE Length = 1042 Score = 100 bits (248), Expect = 9e-20 Identities = 59/174 (33%), Positives = 89/174 (51%), Gaps = 2/174 (1%) Frame = +3 Query: 15 ERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNG 194 ++++ ++ + +SP + G+ E + +RWWE + DG VKW+TLEH G Sbjct: 451 KKKIKKESSEIKTEVVSPTKRKGAK------EEEEEVWRWWEEEKREDG-VKWSTLEHKG 503 Query: 195 VYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRA 368 F P YE P Y+G L L EE ATFYA L D+ K+ F +NFF DFR Sbjct: 504 PVFAPPYERVPRNVRFFYDGRPLDLSEETEEAATFYAKMLNHDYCTKDIFNNNFFKDFRK 563 Query: 369 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 + +K ++I KC+F + + + E +EK+ Q T E K A++ E E Sbjct: 564 SMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNENE 611 [115][TOP] >UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster RepID=TOP1_DROME Length = 972 Score = 100 bits (248), Expect = 9e-20 Identities = 57/158 (36%), Positives = 79/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 42 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 218 K + +SPG+ + E E +RWWE + DG VKW+TLEH G F P YE Sbjct: 402 KEPEPAVSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 456 Query: 219 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395 P Y+G L L EE ATFYA L D+ KE F +NFF DFR + + + Sbjct: 457 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 515 Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 +I KC+F + + + E K+KA K + ++ E Sbjct: 516 IIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 553 [116][TOP] >UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia guttata RepID=UPI000194BDF0 Length = 662 Score = 99.8 bits (247), Expect = 1e-19 Identities = 54/149 (36%), Positives = 81/149 (54%), Gaps = 2/149 (1%) Frame = +3 Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 275 E + + ++WWE K DG VKW LEH G YF P YEP Y+G L L A Sbjct: 92 EEKEAENKWKWWEEEKKEDG-VKWMQLEHRGPYFVPPYEPLPEDVQFYYDGKPLKLSLAT 150 Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 455 EE+ATFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + ++ Sbjct: 151 EEIATFYAKMLNHEYTTKEIFQNNFFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEK 209 Query: 456 KAKKKAEKKAQTTAERKEAREAEAERVRQ 542 +K K E K+ + EA+++++ Sbjct: 210 NEARKGLPK-----EEKQKLKEEADKIQE 233 [117][TOP] >UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI0001555600 Length = 689 Score = 99.8 bits (247), Expect = 1e-19 Identities = 58/178 (32%), Positives = 93/178 (52%), Gaps = 2/178 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K+K + ++A K+ + ++ + ++ S E E G ++WWE + DG VKW L Sbjct: 87 KLKKKDKLASRKSSRKGKSKNEEKSERSDKDQKEDE-GASKWKWWEEEKREDG-VKWKQL 144 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G YF P YEP Y G + L EE+ATFY L ++ K+ F++NFF+ Sbjct: 145 EHRGPYFAPLYEPLPDHVHFYYNGKPMKLSLVTEEIATFYGKMLDHEYTTKDIFQNNFFS 204 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 D+R + + K I LE+CDF+ I + D+ +KA K + ++EA + + E Sbjct: 205 DWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNEARKALPKEEKQKLKEEAEKLQEE 261 [118][TOP] >UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1 Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294 Length = 786 Score = 99.8 bits (247), Expect = 1e-19 Identities = 63/189 (33%), Positives = 96/189 (50%), Gaps = 9/189 (4%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAE------GENGDGGFRWWEAGNKTDGE 164 K+K+E G K K E+ + P + + E + + ++WWE DG Sbjct: 175 KIKSEDEKKGKKRKQEEEDIKPKKKSKGKGNEGEVKKKKVKKEEEEKWKWWEEERHADG- 233 Query: 165 VKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338 +KW LEH G F P YEP Y+G + L P AEEVATF+A L ++ K+ F Sbjct: 234 IKWKFLEHKGPVFAPPYEPLPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIF 293 Query: 339 RSNFFADF-RALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515 R NFF D+ + + AD + +IT+L KCDF+ + + K+++E + T E K+ Sbjct: 294 RKNFFKDWKKEMTADER--NLITNLGKCDFNAMSQYF-----KEQSEARKNMTKEEKQKI 346 Query: 516 EAEAERVRQ 542 + E ER+ Q Sbjct: 347 KEENERLLQ 355 [119][TOP] >UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8IDM1_CHLRE Length = 586 Score = 99.8 bits (247), Expect = 1e-19 Identities = 55/132 (41%), Positives = 78/132 (59%), Gaps = 1/132 (0%) Frame = +3 Query: 138 EAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTD 317 E G+ G+V W TL+H GV FPPEYEPHG +Y+G + L P EEVAT +A +TD Sbjct: 20 EPGSSKSGQVMWKTLKHAGVLFPPEYEPHGVKPLYDGKPVDLTPDQEEVATMFAVMKETD 79 Query: 318 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTT 494 ++ K+ F NF+ F+ +L VI L+KCDF+ I + H+ +AKK K+ + Sbjct: 80 YMNKKVFLDNFWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQREAKKGISKEEKDR 136 Query: 495 AERKEAREAEAE 530 +KE E EA+ Sbjct: 137 I-KKEKDEKEAK 147 [120][TOP] >UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER Length = 969 Score = 99.8 bits (247), Expect = 1e-19 Identities = 58/160 (36%), Positives = 80/160 (50%), Gaps = 2/160 (1%) Frame = +3 Query: 36 KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEY 215 K K E +SP + + + E E +RWWE + DG VKW+TLEH G F P Y Sbjct: 397 KMKKEPEVVSPTKRQKAKVKEEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRY 451 Query: 216 E--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 389 E P Y+G + L EE ATFYA L D+ KE F +NFF DFR + +K Sbjct: 452 ERVPRNVRFYYDGKPMELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKE 510 Query: 390 AKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 ++I KC F+ + + E K+KA K + ++ E Sbjct: 511 REIIKDFRKCGFNEMFNFFQAESEKRKAATKEEKLIKKNE 550 [121][TOP] >UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2 Length = 745 Score = 99.8 bits (247), Expect = 1e-19 Identities = 53/139 (38%), Positives = 82/139 (58%), Gaps = 8/139 (5%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE N+ D +KW TL+HNGV FPP Y+P L Y+G + LPP AEEVA F+A Sbjct: 107 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 165 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 470 + L++DH F+ NFF DF +L ++ I +CDF+++ + + +K +KK Sbjct: 166 ALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKK 225 Query: 471 ---AEKKAQTTAERKEARE 518 +++K Q ER++ E Sbjct: 226 QLTSQEKKQIRLEREKFEE 244 [122][TOP] >UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae RepID=B3LJ50_YEAS1 Length = 769 Score = 99.8 bits (247), Expect = 1e-19 Identities = 53/139 (38%), Positives = 82/139 (58%), Gaps = 8/139 (5%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE N+ D +KW TL+HNGV FPP Y+P L Y+G + LPP AEEVA F+A Sbjct: 131 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 189 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 470 + L++DH F+ NFF DF +L ++ I +CDF+++ + + +K +KK Sbjct: 190 ALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKK 249 Query: 471 ---AEKKAQTTAERKEARE 518 +++K Q ER++ E Sbjct: 250 QLTSQEKKQIRLEREKFEE 268 [123][TOP] >UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae RepID=TOP1_YEAST Length = 769 Score = 99.8 bits (247), Expect = 1e-19 Identities = 53/139 (38%), Positives = 82/139 (58%), Gaps = 8/139 (5%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE N+ D +KW TL+HNGV FPP Y+P L Y+G + LPP AEEVA F+A Sbjct: 131 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 189 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 470 + L++DH F+ NFF DF +L ++ I +CDF+++ + + +K +KK Sbjct: 190 ALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKK 249 Query: 471 ---AEKKAQTTAERKEARE 518 +++K Q ER++ E Sbjct: 250 QLTSQEKKQIRLEREKFEE 268 [124][TOP] >UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q84ZL5_ORYSJ Length = 916 Score = 99.4 bits (246), Expect = 2e-19 Identities = 55/123 (44%), Positives = 71/123 (57%), Gaps = 1/123 (0%) Frame = +3 Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338 G KWTTL H+GV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K+ F Sbjct: 370 GGQKWTTLVHSGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTF 429 Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515 NFF D+R +L VI E CDF+ I E HL ++ EKK Q T+E K+A Sbjct: 430 IDNFFTDWRKILGKN---HVIKKFELCDFTPIYEWHLREK------EKKKQMTSEEKKAL 480 Query: 516 EAE 524 + E Sbjct: 481 KEE 483 [125][TOP] >UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=A2YRB7_ORYSI Length = 916 Score = 99.4 bits (246), Expect = 2e-19 Identities = 55/123 (44%), Positives = 71/123 (57%), Gaps = 1/123 (0%) Frame = +3 Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338 G KWTTL H+GV FPP Y+PHG ++Y G + L P EEVAT +A TD+ K+ F Sbjct: 370 GGQKWTTLVHSGVIFPPPYKPHGVKILYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTF 429 Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515 NFF D+R +L VI E CDF+ I E HL ++ EKK Q T+E K+A Sbjct: 430 IDNFFTDWRKILGKN---HVIKKFELCDFTPIYEWHLREK------EKKKQMTSEEKKAL 480 Query: 516 EAE 524 + E Sbjct: 481 KEE 483 [126][TOP] >UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI Length = 997 Score = 99.4 bits (246), Expect = 2e-19 Identities = 58/170 (34%), Positives = 85/170 (50%), Gaps = 2/170 (1%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLE 185 +K + + + + + T+SP + A E E +RWWE + DG VKW+TLE Sbjct: 401 MKPKMKKVKKEPEIKSETVSPTKRARKDKKDEEEEV----WRWWEEEKREDG-VKWSTLE 455 Query: 186 HNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFAD 359 H G F P YE P Y+G L L EE ATFYA L D+ K+ F +NFF D Sbjct: 456 HKGPVFAPPYERVPRNVRFFYDGKPLDLTEETEEAATFYAKMLNHDYCTKDVFNTNFFKD 515 Query: 360 FRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 FR + D + ++I KC+F + + E ++KA K + A++ E Sbjct: 516 FRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAESERRKAATKDEKLAKKNE 564 [127][TOP] >UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE Length = 970 Score = 99.4 bits (246), Expect = 2e-19 Identities = 57/158 (36%), Positives = 79/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 42 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 218 K + +SPG+ + + E E +RWWE + DG VKW+TLEH G F P YE Sbjct: 400 KEPEPIVSPGKRQKTKVKEEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 454 Query: 219 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395 P Y+G L L EE ATFYA L D+ KE F +NFF DFR + + + Sbjct: 455 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 513 Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 +I KC F + + + E K+KA K + ++ E Sbjct: 514 IIKDFRKCGFQEMFNYFQAESEKRKAASKEEKLIKKNE 551 [128][TOP] >UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG Length = 622 Score = 99.0 bits (245), Expect = 2e-19 Identities = 59/152 (38%), Positives = 81/152 (53%), Gaps = 6/152 (3%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281 E +RWWE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEE Sbjct: 23 EEEQSRWRWWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEE 81 Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 449 VA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I +A +E Sbjct: 82 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 140 Query: 450 DEKAKKKAEKKAQTTAERKEAREAEAERVRQF 545 K K EK RK +EA + + ++ Sbjct: 141 ARKNMSKEEKLVCNIQFRKVLKEANQKILDEY 172 [129][TOP] >UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster RepID=Q8IR39_DROME Length = 581 Score = 99.0 bits (245), Expect = 2e-19 Identities = 56/152 (36%), Positives = 77/152 (50%), Gaps = 2/152 (1%) Frame = +3 Query: 60 LSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFP 233 +SPG+ + E E +RWWE + DG VKW+TLEH G F P YE P Sbjct: 17 VSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVR 71 Query: 234 LIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLE 413 Y+G L L EE ATFYA L D+ KE F +NFF DFR + + ++I Sbjct: 72 FYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFR 130 Query: 414 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 KC+F + + + E K+KA K + ++ E Sbjct: 131 KCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 162 [130][TOP] >UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME Length = 581 Score = 99.0 bits (245), Expect = 2e-19 Identities = 56/152 (36%), Positives = 77/152 (50%), Gaps = 2/152 (1%) Frame = +3 Query: 60 LSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFP 233 +SPG+ + E E +RWWE + DG VKW+TLEH G F P YE P Sbjct: 17 VSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVR 71 Query: 234 LIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLE 413 Y+G L L EE ATFYA L D+ KE F +NFF DFR + + ++I Sbjct: 72 FYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFR 130 Query: 414 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 KC+F + + + E K+KA K + ++ E Sbjct: 131 KCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 162 [131][TOP] >UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR Length = 767 Score = 99.0 bits (245), Expect = 2e-19 Identities = 57/171 (33%), Positives = 86/171 (50%), Gaps = 2/171 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K E G KT+++ A + + ++WWE +G +KW L Sbjct: 164 KRKLEEEEDGKLKKTKNKDKDKKGAESDNKKKKPKKEEEQKWKWWEEERYPEG-IKWKFL 222 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP G Y+G + L P AEEVATF+A L ++ KE FR NFF Sbjct: 223 EHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFK 282 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 D+R + + + VIT+L KCDF+++ + +D+ +K K + ++E Sbjct: 283 DWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSEARKQMSKEEKLKIKEE 332 [132][TOP] >UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH Length = 917 Score = 98.6 bits (244), Expect = 3e-19 Identities = 55/129 (42%), Positives = 76/129 (58%) Frame = +3 Query: 156 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335 DG+ KW TL+HNGV FPP Y+ HG ++++G + L P EEVAT +A +T++ K K Sbjct: 364 DGQKKWKTLQHNGVIFPPPYKRHGVKILFQGKPVDLTPEQEEVATMFAVMRETEYYKKPK 423 Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515 FR NF+ D+R LL +I SL+ CDF+ I EK E K Q TAE K R Sbjct: 424 FRENFWNDWRKLLGKN---HMIKSLDDCDFTPIYEWYMQEK-----ETKKQMTAEEK--R 473 Query: 516 EAEAERVRQ 542 + E+++Q Sbjct: 474 IVKEEKLKQ 482 [133][TOP] >UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299 RepID=C1FD86_9CHLO Length = 635 Score = 98.6 bits (244), Expect = 3e-19 Identities = 57/145 (39%), Positives = 79/145 (54%), Gaps = 3/145 (2%) Frame = +3 Query: 93 GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPA 272 G+A+ + W A K + W+TLEHNGV FPP Y+ HG PL+Y+G ++ L P Sbjct: 88 GSAKKKTKRADHEPWRA--KRGAKQMWSTLEHNGVVFPPPYQAHGIPLVYDGHDVKLLPH 145 Query: 273 AEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED 452 EEVATF+A TD+ K+ F NFF F+ L I +KCDF++I Sbjct: 146 EEEVATFFAVMKDTDYAQKDIFVKNFFDGFKKTLRGGPHG-FIKDFKKCDFTKIYMWNLQ 204 Query: 453 EKAKKK---AEKKAQTTAERKEARE 518 E+ +KK AE+K + AE+ A E Sbjct: 205 ERERKKSVSAEEKRKVKAEQAAAEE 229 [134][TOP] >UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT Length = 926 Score = 98.6 bits (244), Expect = 3e-19 Identities = 53/125 (42%), Positives = 74/125 (59%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV F P Y+PHG ++Y+ L L P EEVAT +A L TD++ K +F+ N Sbjct: 382 KWTTLVHNGVMFLPPYKPHGVKMLYKXQPLTLTPEQEEVATMFAVMLDTDYMTKPRFKEN 441 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 FF+D++ +L + +LE CDF I + EK K +K TT E+K +E Sbjct: 442 FFSDWKKMLGKN---HTVQNLEDCDFGPIYEWHQQEKEK----RKQMTTEEKKALKE--- 491 Query: 528 ERVRQ 542 ER++Q Sbjct: 492 ERLQQ 496 [135][TOP] >UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI Length = 1045 Score = 98.6 bits (244), Expect = 3e-19 Identities = 53/130 (40%), Positives = 68/130 (52%), Gaps = 2/130 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE + DG VKWTTLEH G F P YE P Y+G L L EE ATFYA Sbjct: 485 WRWWEEEKREDG-VKWTTLEHKGPVFAPPYERMPRNVRFYYDGKPLELSEETEEAATFYA 543 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ K+ F +NFF DFR + K ++I KC+F + E K+KA Sbjct: 544 KMLNHDYCTKDVFNNNFFKDFRKSMT-PKEKEIIKDFRKCNFQEMHQFFLAESEKRKAAT 602 Query: 480 KAQTTAERKE 509 K + A++ E Sbjct: 603 KEEKLAKKNE 612 [136][TOP] >UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR Length = 1063 Score = 98.6 bits (244), Expect = 3e-19 Identities = 52/130 (40%), Positives = 68/130 (52%), Gaps = 2/130 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE + DG VKWTTLEH G F P YE P Y+G L L EE ATFYA Sbjct: 503 WRWWEEKRRDDG-VKWTTLEHKGPVFAPPYERVPQNVRFFYDGKPLELSEETEEAATFYA 561 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ K+ F +NFF DFR + K ++I KC+F + + E K+KA Sbjct: 562 KMLNHDYCTKDVFNTNFFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEKRKAAT 620 Query: 480 KAQTTAERKE 509 K + ++ E Sbjct: 621 KEEKLLKKNE 630 [137][TOP] >UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus RepID=TOP1M_MOUSE Length = 593 Score = 98.6 bits (244), Expect = 3e-19 Identities = 57/138 (41%), Positives = 79/138 (57%), Gaps = 2/138 (1%) Frame = +3 Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308 WE +K+ VKW LEH G YF P YEP G +Y+G L L AAEEVATFY L Sbjct: 36 WEETSKSS--VKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKML 93 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 + KE FR NFF+D+R + + ++IT L+KCDF+ I H ++AE + Sbjct: 94 HLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHF-----LERAEARRT 147 Query: 489 TTAERKEAREAEAERVRQ 542 E+K+ + EAE+++Q Sbjct: 148 LPREQKQKLKEEAEKLQQ 165 [138][TOP] >UniRef100_Q504F2 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q504F2_DANRE Length = 321 Score = 98.2 bits (243), Expect = 3e-19 Identities = 66/173 (38%), Positives = 91/173 (52%), Gaps = 2/173 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K E K KT+D+ G A A+ E + ++WWE TDG VKW L Sbjct: 159 KRKQEEEDIKPKKKTKDKK---GEVATDGKKKAKKEPEEK-WKWWEEERYTDG-VKWKFL 213 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP Y+G + L P AEEVATF++ L ++ K+ FR NFF Sbjct: 214 EHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFRKNFFK 273 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515 D+R + + +K IT L KCDFS + + KA+ +A +KA T E+K+ + Sbjct: 274 DWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKKKKK 321 [139][TOP] >UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y3I3_PHATR Length = 594 Score = 98.2 bits (243), Expect = 3e-19 Identities = 56/145 (38%), Positives = 79/145 (54%), Gaps = 5/145 (3%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS- 302 F WW A +G +W T+EH+GV FP YEPHG ++Y+G + L P EE ATF+A+ Sbjct: 4 FLWWNAPELPEG-CQWRTMEHSGVSFPETYEPHGVKMMYDGQPVELTPIQEEAATFFAAM 62 Query: 303 KLQTDHVLKEK----FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK 470 + H+ K F NFFADFR +L ++ +KCDF I HL ++ K Sbjct: 63 DPEGMHLGNPKTGKIFIKNFFADFREILGK---KHIVKEFKKCDFEPIRKHLNEQ----K 115 Query: 471 AEKKAQTTAERKEAREAEAERVRQF 545 +KA T ERK +E ++ + QF Sbjct: 116 IIRKAITDEERKANKEDRSQTLHQF 140 [140][TOP] >UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5C65 Length = 755 Score = 97.4 bits (241), Expect = 6e-19 Identities = 65/187 (34%), Positives = 92/187 (49%), Gaps = 17/187 (9%) Frame = +3 Query: 36 KAKTEDRTLSPGRAAGSPLGAAEGENGDGG---------------FRWWEAGNKTDGEVK 170 K KTE+ + R + A + +N G ++WWE TDG VK Sbjct: 148 KIKTENEKKAKKRKPDENIKAVKTKNKKGDVADGKKKAKKEQEEKWKWWEEERYTDG-VK 206 Query: 171 WTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344 W LEH G F P YEP Y+G L AEEVATF+A L ++ K+ FR Sbjct: 207 WKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFAKMLDHEYTTKDVFRK 266 Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 NFF D+R + + AK IT L+KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 267 NFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEEN 321 Query: 525 AERVRQF 545 ++Q+ Sbjct: 322 ERLLQQY 328 [141][TOP] >UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU Length = 753 Score = 97.4 bits (241), Expect = 6e-19 Identities = 65/187 (34%), Positives = 92/187 (49%), Gaps = 17/187 (9%) Frame = +3 Query: 36 KAKTEDRTLSPGRAAGSPLGAAEGENGDGG---------------FRWWEAGNKTDGEVK 170 K KTE+ + R + A + +N G ++WWE TDG VK Sbjct: 146 KIKTENEKKAKKRKPDENIKAVKTKNKKGDVADGKKKAKKEQEEKWKWWEEERYTDG-VK 204 Query: 171 WTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344 W LEH G F P YEP Y+G L AEEVATF+A L ++ K+ FR Sbjct: 205 WKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFAKMLDHEYTTKDVFRK 264 Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 NFF D+R + + AK IT L+KCDFS + + KA+ +A +KA T E+ + +E Sbjct: 265 NFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEEN 319 Query: 525 AERVRQF 545 ++Q+ Sbjct: 320 ERLLQQY 326 [142][TOP] >UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE Length = 592 Score = 97.4 bits (241), Expect = 6e-19 Identities = 58/138 (42%), Positives = 80/138 (57%), Gaps = 2/138 (1%) Frame = +3 Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308 WE +K+ VKW LEH G YF P YEP G +Y+G L L AAEEVATFY L Sbjct: 36 WEETSKSS--VKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKML 93 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 + KE FR NFF+D+R + + ++IT L+KCDF+ I H ++AE + Sbjct: 94 HLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHF-----LERAEARRT 147 Query: 489 TTAERKEAREAEAERVRQ 542 E+K+ +E EAE+++Q Sbjct: 148 LPREQKQLKE-EAEKLQQ 164 [143][TOP] >UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA Length = 580 Score = 97.4 bits (241), Expect = 6e-19 Identities = 52/130 (40%), Positives = 68/130 (52%), Gaps = 2/130 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE + DG VKW+TLEH G F P YE P Y+G L L EE ATFYA Sbjct: 34 WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYA 92 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ KE F +NFF DFR + +K ++I KC F + + E K+KA Sbjct: 93 KMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEKRKAAT 151 Query: 480 KAQTTAERKE 509 K + ++ E Sbjct: 152 KEEKLIKKNE 161 [144][TOP] >UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B3173 Length = 622 Score = 97.1 bits (240), Expect = 8e-19 Identities = 57/139 (41%), Positives = 75/139 (53%), Gaps = 6/139 (4%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281 E +RWWE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEE Sbjct: 47 EEEQSRWRWWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEE 105 Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 449 VA F+A L ++ K+ FR NFF D+R + D + +I L+KCDF I +A +E Sbjct: 106 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 164 Query: 450 DEKAKKKAEKKAQTTAERK 506 K K EK A +K Sbjct: 165 ARKNMSKEEKLVLKEANQK 183 [145][TOP] >UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus RepID=UPI0000ECD01B Length = 593 Score = 97.1 bits (240), Expect = 8e-19 Identities = 56/145 (38%), Positives = 78/145 (53%), Gaps = 2/145 (1%) Frame = +3 Query: 114 GDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVA 287 G GG WE DG VKW LEH G YF P YEP Y+G L L A EE+A Sbjct: 27 GSGGCSRWEEEKTNDG-VKWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIA 85 Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK 467 TFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ + Sbjct: 86 TFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEAR 144 Query: 468 KAEKKAQTTAERKEAREAEAERVRQ 542 KA K E K+ + EA+++++ Sbjct: 145 KALSK-----EEKQKLKEEADKIQE 164 [146][TOP] >UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus RepID=Q6T722_CHICK Length = 593 Score = 97.1 bits (240), Expect = 8e-19 Identities = 56/145 (38%), Positives = 78/145 (53%), Gaps = 2/145 (1%) Frame = +3 Query: 114 GDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVA 287 G GG WE DG VKW LEH G YF P YEP Y+G L L A EE+A Sbjct: 27 GSGGCSRWEEEKTNDG-VKWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIA 85 Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK 467 TFYA L ++ KE F++NFF D+R + + ++I L+KCDF I + D+ + Sbjct: 86 TFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEAR 144 Query: 468 KAEKKAQTTAERKEAREAEAERVRQ 542 KA K E K+ + EA+++++ Sbjct: 145 KALSK-----EEKQKLKEEADKIQE 164 [147][TOP] >UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B1 Length = 751 Score = 96.7 bits (239), Expect = 1e-18 Identities = 58/142 (40%), Positives = 80/142 (56%), Gaps = 2/142 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE TDG VKW LEH G F P YEP Y+G + L AEEVATF+A Sbjct: 189 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 247 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA+ +A + Sbjct: 248 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-R 302 Query: 480 KAQTTAERKEAREAEAERVRQF 545 KA T E+ + +E ++QF Sbjct: 303 KAMTKEEKLKIKEENERILQQF 324 [148][TOP] >UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B27B0 Length = 751 Score = 96.7 bits (239), Expect = 1e-18 Identities = 58/142 (40%), Positives = 80/142 (56%), Gaps = 2/142 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE TDG VKW LEH G F P YEP Y+G + L AEEVATF+A Sbjct: 189 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 247 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ K+ FR NFF D+R + + AK IT L+KCDFS + + KA+ +A + Sbjct: 248 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-R 302 Query: 480 KAQTTAERKEAREAEAERVRQF 545 KA T E+ + +E ++QF Sbjct: 303 KAMTKEEKLKIKEENERILQQF 324 [149][TOP] >UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO Length = 701 Score = 96.3 bits (238), Expect = 1e-18 Identities = 53/144 (36%), Positives = 77/144 (53%), Gaps = 14/144 (9%) Frame = +3 Query: 129 RWWEAGNKTDGEVK-------------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPP 269 RWWE K D E W LEHNG+ F PEY+PHG P+ ++G + L P Sbjct: 92 RWWE---KVDNEFDLAKIMEYENQSCHWEYLEHNGMIFTPEYKPHGIPIKFKGEPITLTP 148 Query: 270 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK-FAKVITSLEKCDFSRIEAHL 446 EEVATF+A + T++ E +R NF+ F ++ K +L+ CDFS I AHL Sbjct: 149 DLEEVATFWAQSIGTNYEESEIYRRNFWNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHL 208 Query: 447 EDEKAKKKAEKKAQTTAERKEARE 518 + E+ KKK +K+ + + A++ Sbjct: 209 DMEREKKKEQKEYYKALKEETAKK 232 [150][TOP] >UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A48 Length = 632 Score = 95.9 bits (237), Expect = 2e-18 Identities = 60/142 (42%), Positives = 80/142 (56%), Gaps = 3/142 (2%) Frame = +3 Query: 129 RW-WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 RW WE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEEVA F+A Sbjct: 69 RWRWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDNVHFYYDGKKVKLSLAAEEVALFFA 127 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ K+ FR NFF D+R + D + +I L KCDF I A KAK +A + Sbjct: 128 QMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKAKVEA-R 182 Query: 480 KAQTTAERKEAREAEAERVRQF 545 K T E++ +EA + V +F Sbjct: 183 KNMTKEEKQALKEANQKIVDEF 204 [151][TOP] >UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR Length = 874 Score = 95.1 bits (235), Expect = 3e-18 Identities = 56/145 (38%), Positives = 79/145 (54%), Gaps = 11/145 (7%) Frame = +3 Query: 126 FRWWE-AGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFY 296 ++WWE + K D +KWTTLEHNGV FP +Y+ P L+Y+G + L AEE ATF+ Sbjct: 224 YKWWEESAKKEDDSIKWTTLEHNGVIFPEDYQRLPKDVKLLYDGTPVELDIEAEEAATFF 283 Query: 297 ASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLED 452 L T +V F+ NFF DF+ +L T AK I EK DFS++ A+ + Sbjct: 284 GFMLNSTVNVENPTFQKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWAYKDA 343 Query: 453 EKAKKKAEKKAQTTAERKEAREAEA 527 + K A A+ AE+ E + +A Sbjct: 344 QTKAKNARSSAEKKAEKAERDKRDA 368 [152][TOP] >UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792028 Length = 1011 Score = 94.7 bits (234), Expect = 4e-18 Identities = 61/164 (37%), Positives = 82/164 (50%), Gaps = 3/164 (1%) Frame = +3 Query: 36 KAKTEDRTLSP-GRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212 K K E+ T G+P E E + ++WWE K DG VKW LEH G F P Sbjct: 157 KVKKENNTSQKESPVKGTPKKKKEEEPQEV-WKWWEEEKKDDG-VKWKFLEHKGPVFAPA 214 Query: 213 YEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386 YEP Y G ++ L AEEVATFYA L+ D+ KE F NF D+R + K Sbjct: 215 YEPLPSNVKFYYNGKQVVLSELAEEVATFYAKMLEHDYTTKEVFNKNFLKDWRKTMT-PK 273 Query: 387 FAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 ++IT L C+F + + KK E+KA + E+K+ +E Sbjct: 274 EKELITDLSLCNFKEMNVYF----TKKSEERKAMSKEEKKKIKE 313 [153][TOP] >UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F97 Length = 790 Score = 94.7 bits (234), Expect = 4e-18 Identities = 63/185 (34%), Positives = 91/185 (49%), Gaps = 5/185 (2%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENG---DGGFRWWEAGNKTDGEVKW 173 KVK E K K E + P + EG+ + ++WWE TDG KW Sbjct: 200 KVKTEHDKKSKKRKHEYEDIKPKKKKKDK-NVTEGKKSKKDEEKWKWWEEERSTDGS-KW 257 Query: 174 TTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 LEH G F P YEP Y+G + L AEEVATF+A L ++ K+ FR N Sbjct: 258 RFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKN 317 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ + + Sbjct: 318 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 371 Query: 528 ERVRQ 542 ER+ Q Sbjct: 372 ERILQ 376 [154][TOP] >UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus norvegicus RepID=UPI0001B7BF13 Length = 760 Score = 94.0 bits (232), Expect = 7e-18 Identities = 52/139 (37%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP G Y+G + L P AEEVATF+A Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLQEGVKFYYDGKVMKLSPKAEEVATFFA 261 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + IT+L KCDF+++ + K ++E Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 315 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 316 RKQMSKEEKLKIKEENEKL 334 [155][TOP] >UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT Length = 767 Score = 94.0 bits (232), Expect = 7e-18 Identities = 52/139 (37%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP G Y+G + L P AEEVATF+A Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFA 263 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + IT+L KCDF+++ + K ++E Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 317 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 318 RKQMSKEEKLKIKEENEKL 336 [156][TOP] >UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus RepID=TOP1M_RAT Length = 593 Score = 94.0 bits (232), Expect = 7e-18 Identities = 54/135 (40%), Positives = 74/135 (54%), Gaps = 2/135 (1%) Frame = +3 Query: 144 GNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTD 317 G + VKW LEH G F P YEP G Y+G + L AAEEVATFY L + Sbjct: 37 GETSKSSVKWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLE 96 Query: 318 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 497 KE FR NFF+D++ + + K+IT L+KCDFS I H ++AE + Sbjct: 97 CTTKEVFRRNFFSDWQKEMT-AEERKLITHLDKCDFSEIHRHF-----MERAEARRTLPR 150 Query: 498 ERKEAREAEAERVRQ 542 E+K+ + EAE+++Q Sbjct: 151 EQKQKLKEEAEKLQQ 165 [157][TOP] >UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus caballus RepID=UPI0001797824 Length = 765 Score = 93.6 bits (231), Expect = 9e-18 Identities = 52/139 (37%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 261 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +ITSL KCDF+++ + K + E Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF-----KAQTEA 315 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 316 RKQMSKEEKLKIKEENEKL 334 [158][TOP] >UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F96 Length = 767 Score = 93.6 bits (231), Expect = 9e-18 Identities = 57/171 (33%), Positives = 89/171 (52%), Gaps = 2/171 (1%) Frame = +3 Query: 36 KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEY 215 K K +D+ ++ G+ + + + ++WWE TDG KW LEH G F P Y Sbjct: 184 KKKKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPY 233 Query: 216 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 389 EP Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + Sbjct: 234 EPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEK 293 Query: 390 AKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 +K IT L KC+F+ + +E K ++E + Q + E K+ + + ER+ Q Sbjct: 294 SK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDNERILQ 338 [159][TOP] >UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA Length = 892 Score = 93.6 bits (231), Expect = 9e-18 Identities = 50/127 (39%), Positives = 72/127 (56%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV FPP Y+PHG ++Y G + L P YA TD++ K++F+ N Sbjct: 344 KWTTLVHNGVIFPPPYKPHGVKMLYMGRPVDLTPELRRGCYKYAVMRDTDYMQKDRFKEN 403 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 F+ D+R LL VI +L+ CDF+ I + EK K KK TT E+K +E + Sbjct: 404 FWNDWRKLLGRN---HVIQNLKDCDFTPIYDWCQSEKEK----KKQMTTEEKKALKEEKL 456 Query: 528 ERVRQFT 548 ++ ++T Sbjct: 457 KQEEKYT 463 [160][TOP] >UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MGX0_9CHLO Length = 685 Score = 93.2 bits (230), Expect = 1e-17 Identities = 48/122 (39%), Positives = 71/122 (58%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 +W TLEH+GV FPP YEP+ PL Y+G+++ L P EE A F+A TD+ K+ F N Sbjct: 163 QWKTLEHHGVVFPPPYEPNKVPLTYDGVDIVLLPHEEEAANFFAVMKDTDYAQKDVFVKN 222 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 F+ F+ +L A I +KCDF+++ E+ KKKA + + K A++AE Sbjct: 223 FWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHLKEREKKKAISN-EDKKKAKAAKDAEE 281 Query: 528 ER 533 E+ Sbjct: 282 EK 283 [161][TOP] >UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus scrofa RepID=UPI00017EFDA4 Length = 748 Score = 92.8 bits (229), Expect = 1e-17 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 187 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 245 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K ++E Sbjct: 246 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 299 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 300 RKQMSKEEKLKIKEENEKL 318 [162][TOP] >UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta RepID=UPI00006D45A8 Length = 767 Score = 92.8 bits (229), Expect = 1e-17 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K ++E Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 317 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 318 RKQMSKEEKLKIKEENEKL 336 [163][TOP] >UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI00005A45B7 Length = 1004 Score = 92.8 bits (229), Expect = 1e-17 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 442 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 500 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K ++E Sbjct: 501 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 554 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 555 RKQMSKEEKLKIKEENEKL 573 [164][TOP] >UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30 Length = 752 Score = 92.8 bits (229), Expect = 1e-17 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 190 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 248 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K ++E Sbjct: 249 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 302 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 303 RKQMSKEEKLKIKEENEKL 321 [165][TOP] >UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU Length = 767 Score = 92.8 bits (229), Expect = 1e-17 Identities = 56/171 (32%), Positives = 88/171 (51%), Gaps = 2/171 (1%) Frame = +3 Query: 36 KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEY 215 K K +D+ ++ G+ + + + ++WWE TDG KW LEH G F P Y Sbjct: 184 KKKKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPY 233 Query: 216 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 389 EP Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + Sbjct: 234 EPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEK 293 Query: 390 AKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 +K IT L KC+F+ + + K ++E + Q + E K+ + + ER+ Q Sbjct: 294 SK-ITDLNKCNFAGMNDYF-----KAQSEARKQMSKEEKQKIKEDNERILQ 338 [166][TOP] >UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG Length = 806 Score = 92.8 bits (229), Expect = 1e-17 Identities = 55/124 (44%), Positives = 69/124 (55%), Gaps = 6/124 (4%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE TDG VKW LEH G F P YEP Y+G + L AEEVATF+A Sbjct: 171 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 229 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKK 467 L ++ K+ FR NFF D+R + + AK IT L+KCDFS + +A E KA Sbjct: 230 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTEARKAMT 288 Query: 468 KAEK 479 K EK Sbjct: 289 KEEK 292 [167][TOP] >UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata RepID=UPI000194D872 Length = 775 Score = 92.4 bits (228), Expect = 2e-17 Identities = 59/180 (32%), Positives = 87/180 (48%), Gaps = 2/180 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K + E K K++D+ + P E + ++WWE +G +KW L Sbjct: 177 KQEEEEDSKAKKIKSKDKKVPEADKRKKPKKEEEQK-----WKWWEEERYPEG-IKWKFL 230 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP Y+G + L AEEVATF+A L ++ KE FR NFF Sbjct: 231 EHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFK 290 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536 D+R + + ITSL KCDF+ + + K ++E + Q + E K+ + E ER+ Sbjct: 291 DWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQSEARKQMSKEEKQKIKEENERL 344 [168][TOP] >UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus RepID=UPI00006154BF Length = 769 Score = 92.4 bits (228), Expect = 2e-17 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 207 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 265 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K + E Sbjct: 266 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 319 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 320 RKQMSKEEKLKIKEENEKL 338 [169][TOP] >UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK Length = 766 Score = 92.4 bits (228), Expect = 2e-17 Identities = 60/180 (33%), Positives = 85/180 (47%), Gaps = 2/180 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K + E KAK +D+ P E + ++WWE +G +KW L Sbjct: 168 KQEEEEDSKAKKAKNKDKKSPEADKRKKPKKEEEQK-----WKWWEEERYPEG-IKWKFL 221 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP Y+G + L AEEVATF+A L ++ KE FR NFF Sbjct: 222 EHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFK 281 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536 D+R + + ITSL KCDF+ + + K + E + Q + E K+ + E ER+ Sbjct: 282 DWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQTEARKQMSKEEKQKIKEENERL 335 [170][TOP] >UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN Length = 765 Score = 92.4 bits (228), Expect = 2e-17 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 261 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K + E Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 315 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 316 RKQMSKEEKLKIKEENEKL 334 [171][TOP] >UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN Length = 765 Score = 92.4 bits (228), Expect = 2e-17 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 261 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K + E Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 315 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 316 RKQMSKEEKLKIKEENEKL 334 [172][TOP] >UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica RepID=UPI0000F2B3E5 Length = 916 Score = 92.0 bits (227), Expect = 2e-17 Identities = 52/139 (37%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 354 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 412 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ K+ FR NFF D+R + + + IT+L KCDF++I + K ++E Sbjct: 413 KMLDHEYTTKDIFRKNFFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF-----KAQSEA 466 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E ER+ Sbjct: 467 RKQMSKEEKLKIKEENERL 485 [173][TOP] >UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE Length = 767 Score = 92.0 bits (227), Expect = 2e-17 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPDSVKFYYDGKVMKLSPKAEEVATFFA 263 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K + E Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 317 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 318 RKQMSKEEKLKIKEENEKL 336 [174][TOP] >UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0 Length = 758 Score = 91.7 bits (226), Expect = 3e-17 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 196 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 254 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + IT+L KCDF+++ + K ++E Sbjct: 255 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 308 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 309 RKQMSKEEKLKIKEENEKL 327 [175][TOP] >UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5A49 Length = 692 Score = 91.7 bits (226), Expect = 3e-17 Identities = 55/130 (42%), Positives = 70/130 (53%), Gaps = 3/130 (2%) Frame = +3 Query: 129 RW-WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 RW WE DG VKW LEH+G YFPPEY+P Y+G ++ L AAEEVA F+A Sbjct: 68 RWRWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDNVHFYYDGKKVKLSLAAEEVALFFA 126 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ K+ FR NFF D+R + D + +I L KCDF I A K K E Sbjct: 127 QMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHA-----MHKAKVEA 180 Query: 480 KAQTTAERKE 509 + T E K+ Sbjct: 181 RKNMTKEEKQ 190 [176][TOP] >UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva RepID=Q4N5U3_THEPA Length = 1003 Score = 91.7 bits (226), Expect = 3e-17 Identities = 50/142 (35%), Positives = 75/142 (52%), Gaps = 13/142 (9%) Frame = +3 Query: 129 RWWEAGNKTDGEV-------------KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPP 269 RWWE + DG++ +W LEHNG+ F PEY PH P+ +G +HLPP Sbjct: 313 RWWE---EIDGDMDYNKGLEFESKSSRWKYLEHNGMIFTPEYVPHNVPIKVKGETIHLPP 369 Query: 270 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLE 449 EE+AT +A + T++ + + NF+ F + F + L DFS I+ HLE Sbjct: 370 HLEEIATMWAQSIGTNYETSDIYCKNFWQVFVSKFEKDHFIR-RCKLTDVDFSLIKTHLE 428 Query: 450 DEKAKKKAEKKAQTTAERKEAR 515 DEK KKK K+ ++++A+ Sbjct: 429 DEKQKKKDNKEFYKAKQQEDAK 450 [177][TOP] >UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE Length = 767 Score = 91.7 bits (226), Expect = 3e-17 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ KE FR NFF D+R + + + IT+L KCDF+++ + K ++E Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 317 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K + E E++ Sbjct: 318 RKQMSKEEKLKIKEENEKL 336 [178][TOP] >UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155C8C4 Length = 781 Score = 91.3 bits (225), Expect = 4e-17 Identities = 50/139 (35%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 219 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 277 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L ++ K+ FR NFF D+R + + + + IT+L KCDF+ + + K ++E Sbjct: 278 KMLDHEYTTKDIFRKNFFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF-----KAQSEA 331 Query: 480 KAQTTAERKEAREAEAERV 536 + Q + E K+ + E E++ Sbjct: 332 RKQMSKEEKQKIKEENEQL 350 [179][TOP] >UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA Length = 790 Score = 91.3 bits (225), Expect = 4e-17 Identities = 49/117 (41%), Positives = 70/117 (59%) Frame = +3 Query: 180 LEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFAD 359 L HNGV FPP Y+PHG ++Y + L P EEVAT +A L+T+++ K KFR NF +D Sbjct: 220 LVHNGVIFPPLYKPHGVKMLYRENPVDLTPEQEEVATMFAVMLETEYMTKPKFRENFMSD 279 Query: 360 FRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 +R +L + +I +LE CDF+ I + EK K KK +T E+K +E + E Sbjct: 280 WRKILGE---KHIIQNLEDCDFTPIYEWHQREKEK----KKQMSTDEKKAIKEGKDE 329 [180][TOP] >UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis RepID=UPI00017B1DB6 Length = 770 Score = 90.9 bits (224), Expect = 6e-17 Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%) Frame = +3 Query: 42 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 221 K +D+ ++ G+ + + + ++WWE TDG KW L H G F P YEP Sbjct: 189 KKKDKNVTEGK---------KSKKDEEKWKWWEEERYTDGS-KWRFLGHKGPVFAPPYEP 238 Query: 222 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395 Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K Sbjct: 239 LPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 298 Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 IT L KC+F+ + +E K ++E + Q + E K+ + E ER+ Q Sbjct: 299 -ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEENERILQ 341 [181][TOP] >UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG Length = 783 Score = 90.9 bits (224), Expect = 6e-17 Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%) Frame = +3 Query: 42 KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 221 K +D+ ++ G+ + + + ++WWE TDG KW L H G F P YEP Sbjct: 170 KKKDKNVTEGK---------KSKKDEEKWKWWEEERYTDGS-KWRFLGHKGPVFAPPYEP 219 Query: 222 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395 Y+G + L AEEVATF+A L ++ K+ FR NFF D+R + + +K Sbjct: 220 LPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 279 Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542 IT L KC+F+ + +E K ++E + Q + E K+ + E ER+ Q Sbjct: 280 -ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEENERILQ 322 [182][TOP] >UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata RepID=Q4UDP8_THEAN Length = 999 Score = 90.9 bits (224), Expect = 6e-17 Identities = 48/139 (34%), Positives = 73/139 (52%), Gaps = 10/139 (7%) Frame = +3 Query: 129 RWWEAGNKT----------DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 RWWE ++ +W LEHNG+ F PEY PH P++ +G +HLPP E Sbjct: 314 RWWEEIDEDMDYNKGLEFESKSSRWKYLEHNGMIFTPEYVPHNIPIMVKGETIHLPPNLE 373 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 458 E+AT +A + T++ E + NF+ F + F + L DFS I+ HLE+EK Sbjct: 374 EIATMWAQSMGTNYETSEIYCKNFWQVFVSKFEKDHFIR-RCKLSDADFSLIKNHLEEEK 432 Query: 459 AKKKAEKKAQTTAERKEAR 515 KKK K+ ++++A+ Sbjct: 433 QKKKDNKEFYKAKQQEDAK 451 [183][TOP] >UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio RepID=UPI0001A2C88D Length = 609 Score = 90.5 bits (223), Expect = 7e-17 Identities = 61/175 (34%), Positives = 89/175 (50%), Gaps = 3/175 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K + ER V+ K KT++ AA + + E +RWWE K + +KW L Sbjct: 10 KEEGERPVSTKKKKTKEEI----EAARALKIKKKEEEEKQRWRWWEE-EKYENGIKWKFL 64 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G YFPP Y+P Y G + L AEEVA ++A L ++ KE FR+NFF Sbjct: 65 EHKGPYFPPAYQPLPDDVKFYYNGEPVKLSLPAEEVALYFAQMLDHEYTTKEVFRNNFFK 124 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEARE 518 D+R + + ++I L+KCDF + A H E +A+K K+ + KEA + Sbjct: 125 DWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKEEKLV--NKEANQ 176 [184][TOP] >UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5F98 Length = 790 Score = 90.5 bits (223), Expect = 7e-17 Identities = 60/174 (34%), Positives = 86/174 (49%), Gaps = 5/174 (2%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENG---DGGFRWWEAGNKTDGEVKW 173 KVK E K K E + + P + EG+ + ++WWE TDG KW Sbjct: 135 KVKTEHDKKSKKRKHEFQDIKPKKKKKDK-NVTEGKKSKKDEEKWKWWEEERSTDGS-KW 192 Query: 174 TTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 LEH G F P YEP Y+G + L AEEVATF+A L ++ K+ FR N Sbjct: 193 RFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKN 252 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 FF D+R + + +K IT L KC+F+ + +E K ++E + Q + E K+ Sbjct: 253 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQ 300 [185][TOP] >UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA Length = 969 Score = 90.1 bits (222), Expect = 9e-17 Identities = 52/137 (37%), Positives = 73/137 (53%), Gaps = 6/137 (4%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE + DG VKW LEH G F P Y+P +Y+G E+ L AEEVA FYA Sbjct: 428 WKWWEEEKRDDG-VKWKYLEHKGPVFAPPYDPLPSHVKFMYDGKEMKLSQDAEEVAGFYA 486 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL----EDEKAKK 467 L+ D+ K+ F NFF D+R + + + IT LEKC+F + A+ E + + Sbjct: 487 RMLEHDYTSKQAFNDNFFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEIAEQNRNRS 545 Query: 468 KAEKKAQTTAERKEARE 518 K EK A A + +E Sbjct: 546 KEEKAALKAANEQLTKE 562 [186][TOP] >UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG RepID=B9Q6S5_TOXGO Length = 953 Score = 90.1 bits (222), Expect = 9e-17 Identities = 53/148 (35%), Positives = 76/148 (51%), Gaps = 21/148 (14%) Frame = +3 Query: 108 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 EN + RWWE A + + E +W+ LEHNG+ F P YEPHG L Y G + LPP AE Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQLTYHGKPVSLPPEAE 343 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 413 EVA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403 Query: 414 ---KCDFSRIEAHLEDEKAKKKAEKKAQ 488 CDFS I+ +L+ +K KK K + Sbjct: 404 GFAACDFSPIKEYLDKQKELKKEMSKEE 431 [187][TOP] >UniRef100_Q28GG2 Novel protein similar to topoisomerase (DNA) I top1 (Fragment) n=1 Tax=Xenopus (Silurana) tropicalis RepID=Q28GG2_XENTR Length = 335 Score = 89.4 bits (220), Expect = 2e-16 Identities = 56/155 (36%), Positives = 79/155 (50%), Gaps = 6/155 (3%) Frame = +3 Query: 33 GKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212 G K + +T AA + + E +RWWE DG +KW LEH G F P Sbjct: 182 GAIKAKKKTQEEKEAAAALKLKKKEEEEQMRWRWWEEEKYEDG-IKWKFLEHEGPVFAPP 240 Query: 213 YEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386 YEP Y+G L L AEEVA+F+A L ++ KE FR+N+F D+R + + Sbjct: 241 YEPLPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LE 299 Query: 387 FAKVITSLEKCDFSRI----EAHLEDEKAKKKAEK 479 VIT L KCDF+ + + +E++K K K +K Sbjct: 300 ERMVITDLAKCDFTEMFTYYKGKMEEKKNKSKEDK 334 [188][TOP] >UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus (Silurana) tropicalis RepID=Q0V9D3_XENTR Length = 495 Score = 89.4 bits (220), Expect = 2e-16 Identities = 56/155 (36%), Positives = 79/155 (50%), Gaps = 6/155 (3%) Frame = +3 Query: 33 GKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212 G K + +T AA + + E +RWWE DG +KW LEH G F P Sbjct: 88 GAIKAKKKTQEEKEAAAALKLKKKEEEEQMRWRWWEEEKYEDG-IKWKFLEHEGPVFAPP 146 Query: 213 YEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386 YEP Y+G L L AEEVA+F+A L ++ KE FR+N+F D+R + + Sbjct: 147 YEPLPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LE 205 Query: 387 FAKVITSLEKCDFSRI----EAHLEDEKAKKKAEK 479 VIT L KCDF+ + + +E++K K K +K Sbjct: 206 ERMVITDLAKCDFTEMFTYYKGKMEEKKNKSKEDK 240 [189][TOP] >UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1 RepID=B9PWF4_TOXGO Length = 953 Score = 89.4 bits (220), Expect = 2e-16 Identities = 52/148 (35%), Positives = 76/148 (51%), Gaps = 21/148 (14%) Frame = +3 Query: 108 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 EN + RWWE A + + E +W+ LEHNG+ F P YEPHG + Y G + LPP AE Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAE 343 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 413 EVA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403 Query: 414 ---KCDFSRIEAHLEDEKAKKKAEKKAQ 488 CDFS I+ +L+ +K KK K + Sbjct: 404 GFAACDFSPIKEYLDKQKELKKEMSKEE 431 [190][TOP] >UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49 RepID=B6KM03_TOXGO Length = 953 Score = 89.4 bits (220), Expect = 2e-16 Identities = 52/148 (35%), Positives = 76/148 (51%), Gaps = 21/148 (14%) Frame = +3 Query: 108 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278 EN + RWWE A + + E +W+ LEHNG+ F P YEPHG + Y G + LPP AE Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAE 343 Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 413 EVA ++ L++D+ K +F NF+ F +L + FA+ + E Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403 Query: 414 ---KCDFSRIEAHLEDEKAKKKAEKKAQ 488 CDFS I+ +L+ +K KK K + Sbjct: 404 GFAACDFSPIKEYLDKQKELKKEMSKEE 431 [191][TOP] >UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16 RepID=A8XXL4_CAEBR Length = 840 Score = 88.6 bits (218), Expect = 3e-16 Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRA-AGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179 K K +++ K + T +P + P E + + WW+ K DG VKW T Sbjct: 222 KKKKKKKKKAKAEKNKPSTSTPAKNNKKEPSKKKVKEEQEEIWEWWKEEKKPDG-VKWNT 280 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 L+H G F P Y P Y G + L PAAEE ATFYA + ++ + +F +NF Sbjct: 281 LQHCGPLFAPAYIPLPDHVHFKYNGHRMKLSPAAEECATFYAGVVNHEYSSQVQFNTNFM 340 Query: 354 ADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533 D+R L+ + K IT L KCDF+ H+ + + +++ +KA T E+ + +E +A+ Sbjct: 341 KDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNEQREIRKAMTKEEKAKIKEEKAQE 395 Query: 534 V 536 V Sbjct: 396 V 396 [192][TOP] >UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium parvum Iowa II RepID=Q5CY81_CRYPV Length = 653 Score = 88.2 bits (217), Expect = 4e-16 Identities = 45/126 (35%), Positives = 65/126 (51%) Frame = +3 Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308 +WWE K + ++W LEH GV F P Y+ H PL Y G + LPP AEE+A++++ Sbjct: 43 KWWERPPKEELGIQWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMK 102 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 T+ KEKF +N F + EKC+F I+ + EDEK KK K + Sbjct: 103 DTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEE 162 Query: 489 TTAERK 506 ++K Sbjct: 163 KELQKK 168 [193][TOP] >UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis RepID=Q5CN58_CRYHO Length = 641 Score = 88.2 bits (217), Expect = 4e-16 Identities = 45/126 (35%), Positives = 65/126 (51%) Frame = +3 Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308 +WWE K + ++W LEH GV F P Y+ H PL Y G + LPP AEE+A++++ Sbjct: 31 KWWERPPKEELGIQWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMK 90 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 T+ KEKF +N F + EKC+F I+ + EDEK KK K + Sbjct: 91 DTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEE 150 Query: 489 TTAERK 506 ++K Sbjct: 151 KELQKK 156 [194][TOP] >UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi RepID=A8Q2Z1_BRUMA Length = 751 Score = 87.8 bits (216), Expect = 5e-16 Identities = 49/142 (34%), Positives = 75/142 (52%), Gaps = 6/142 (4%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 281 E+ + ++WWE K G +KW +L H G F P Y P Y+G + L P EE Sbjct: 193 EDEEEVWKWWEEEKKPSG-IKWYSLSHKGPIFAPPYVSLPESIHFKYDGKVMKLAPLTEE 251 Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL----E 449 VA+FYA L+ ++ K+ F NFF D+R ++ + K IT L KCDF + H E Sbjct: 252 VASFYAKILEHEYTTKDIFNKNFFTDWRKVMTPAEREK-ITDLTKCDFREMHDHYIKLRE 310 Query: 450 DEKAKKKAEKKAQTTAERKEAR 515 + ++ K EK+ +++EA+ Sbjct: 311 ERRSLSKEEKQKLKEIKQEEAK 332 [195][TOP] >UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA Length = 560 Score = 87.4 bits (215), Expect = 6e-16 Identities = 50/136 (36%), Positives = 74/136 (54%), Gaps = 2/136 (1%) Frame = +3 Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308 WE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A L Sbjct: 1 WEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML 59 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 ++ KE FR NFF D+R + + + +IT+L KCDF+++ + K ++E + Q Sbjct: 60 DHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEARKQ 113 Query: 489 TTAERKEAREAEAERV 536 + E K + E E++ Sbjct: 114 MSKEEKLKIKEENEKL 129 [196][TOP] >UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum RepID=Q5C1T3_SCHJA Length = 330 Score = 87.0 bits (214), Expect = 8e-16 Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 3/164 (1%) Frame = +3 Query: 36 KAKTEDRTLSPGRAAGSPL-GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212 +++T + A SP G + + + +RWWE K DG VKW LEH G F P Sbjct: 85 RSRTTHEKIKKQNALSSPTKGRKQEKPEEEVWRWWEEQKKDDG-VKWKFLEHKGPLFAPP 143 Query: 213 YE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386 YE P Y+ + L AEEVA FYA L D+ KE F NFF D+ + + + Sbjct: 144 YERLPSSVHFHYDSKPMKLSDHAEEVAGFYARMLDHDYTTKEVFNHNFFHDWVKTMNEEE 203 Query: 387 FAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518 + I SL KCDF + + K E+K +T E+++ +E Sbjct: 204 -RRTIKSLSKCDFQEMHQYF----LKLSEERKNRTKEEKQKIKE 242 [197][TOP] >UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE Length = 966 Score = 87.0 bits (214), Expect = 8e-16 Identities = 56/172 (32%), Positives = 82/172 (47%), Gaps = 2/172 (1%) Frame = +3 Query: 12 AERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHN 191 A ++ K ++ T SP + + E + ++WWE + DG VKW TLEH Sbjct: 377 AAKKKKQAKQVKKEETASPTKGRKK-----KQEEEEEVWKWWEEEKREDG-VKWNTLEHK 430 Query: 192 GVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFR 365 G F P YEP Y+G + L AEE+A FYA L+ ++ K+ F NFF D+R Sbjct: 431 GPVFAPPYEPLPDNVKFEYDGKVIKLSQDAEEIAGFYARMLEHEYTSKDAFNDNFFKDWR 490 Query: 366 ALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521 + ++ K I L+KC+F + H + + K Q A KE EA Sbjct: 491 KSMTSSEREK-IKDLKKCNFRSMHKHFAEISEANRNRTKEQKLA-LKEQNEA 540 [198][TOP] >UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes RepID=UPI00016E5FAF Length = 573 Score = 86.3 bits (212), Expect = 1e-15 Identities = 52/138 (37%), Positives = 74/138 (53%), Gaps = 2/138 (1%) Frame = +3 Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308 WE TDG KW LEH G F P YEP Y+G + L AEEVATF+A L Sbjct: 14 WEEERSTDGS-KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKML 72 Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 ++ K+ FR NFF D+R + + +K IT L KC+F+ + +E K ++E + Q Sbjct: 73 DHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQ 126 Query: 489 TTAERKEAREAEAERVRQ 542 + E K+ + + ER+ Q Sbjct: 127 MSKEEKQKIKEDNERILQ 144 [199][TOP] >UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus RepID=B0WA62_CULQU Length = 962 Score = 85.5 bits (210), Expect = 2e-15 Identities = 58/175 (33%), Positives = 86/175 (49%), Gaps = 6/175 (3%) Frame = +3 Query: 6 VKAERRVAGGKAKTE--DRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179 VK E + K KTE T SP + E E ++WWE + DG VKW Sbjct: 370 VKKENKT---KVKTEVKQETASPTKGGRKKKQEEEQEV----WKWWEEEKREDG-VKWNF 421 Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353 LEH G F P Y+P Y+G + L EEVA FYA ++ ++ K+ F NFF Sbjct: 422 LEHKGPVFAPPYDPLPENVKFEYDGKVMKLSQDTEEVAGFYARMIEHEYTSKDVFNDNFF 481 Query: 354 ADFRALLADTKFAKVITSLEKCDFSRIEAHLED--EKAKKKAEKKAQTTAERKEA 512 D+R + ++ K I L+KC+F + A+ D EK + +++++ E+ EA Sbjct: 482 KDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSEKNRNRSKEEKLALKEQNEA 535 [200][TOP] >UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2) (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD Length = 620 Score = 85.1 bits (209), Expect = 3e-15 Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 4/135 (2%) Frame = +3 Query: 150 KTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEG--MELHLPPAAEEVATFYASKLQTD 317 K+ G VKWT LEH G +F YE P G P + + + L AAEEVATFY KL + Sbjct: 1 KSPGGVKWTQLEHRGPWFAAPYEPLPEGVPSTTDRLLLTIKLILAAEEVATFYGKKLDRE 60 Query: 318 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 497 + KE F++NFF+D+R + + +VI L++CDF+ I H D+ A +KA + Sbjct: 61 YT-KEVFQNNFFSDWRKEMT-AEEGRVIKHLDRCDFTEIHRHSVDKTASQKA-----LSR 113 Query: 498 ERKEAREAEAERVRQ 542 E K+ + E E+++Q Sbjct: 114 EEKQKLKEEEEKLQQ 128 [201][TOP] >UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni RepID=C4Q6C8_SCHMA Length = 587 Score = 84.7 bits (208), Expect = 4e-15 Identities = 51/133 (38%), Positives = 68/133 (51%), Gaps = 2/133 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG VKW LEH G F P YE P Y+ + L AEEVA FYA Sbjct: 124 WRWWEEQKKDDG-VKWKFLEHKGPLFAPPYERLPSSVHFHYDSKPIKLSDHAEEVAGFYA 182 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ KE F NFF D+ + + + + I SL KCDF + + K E+ Sbjct: 183 RMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEER 237 Query: 480 KAQTTAERKEARE 518 K +T E+++ +E Sbjct: 238 KNRTKEEKQKIKE 250 [202][TOP] >UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni RepID=C4Q6C7_SCHMA Length = 652 Score = 84.7 bits (208), Expect = 4e-15 Identities = 51/133 (38%), Positives = 68/133 (51%), Gaps = 2/133 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 +RWWE K DG VKW LEH G F P YE P Y+ + L AEEVA FYA Sbjct: 124 WRWWEEQKKDDG-VKWKFLEHKGPLFAPPYERLPSSVHFHYDSKPIKLSDHAEEVAGFYA 182 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L D+ KE F NFF D+ + + + + I SL KCDF + + K E+ Sbjct: 183 RMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEER 237 Query: 480 KAQTTAERKEARE 518 K +T E+++ +E Sbjct: 238 KNRTKEEKQKIKE 250 [203][TOP] >UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SIQ6_9PEZI Length = 891 Score = 84.3 bits (207), Expect = 5e-15 Identities = 61/184 (33%), Positives = 89/184 (48%), Gaps = 6/184 (3%) Frame = +3 Query: 12 AERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHN 191 A+ G KAK GR+A + E E + WW K D VKWTTLEHN Sbjct: 207 AKTPAKGTKAKAATPA-KKGRSAKKE-ESEEAEEDEAVDEWWNEPKKEDDSVKWTTLEHN 264 Query: 192 GVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQT-DHVLKEKFRSNFFADF 362 GV +YE P L+Y+G L+LP EE A F+ S + ++V F+ NFF DF Sbjct: 265 GVLMDYKYEPLPKNVKLVYDGKPLNLPLQVEEAAWFFGSMFHSKNNVDNPTFQKNFFEDF 324 Query: 363 RALLADTKFA--KVITSLEKCDFSRIE-AHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533 R ++ + A K ++ DF +I + D ++ A +K +T E+K+ +E + R Sbjct: 325 REVIKEHGSATDKDGKKVDIKDFHKINWQPMADYAEQQSAMRKNRTKEEKKQIKEEKDAR 384 Query: 534 VRQF 545 F Sbjct: 385 EEPF 388 [204][TOP] >UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI Length = 638 Score = 83.2 bits (204), Expect = 1e-14 Identities = 48/130 (36%), Positives = 63/130 (48%), Gaps = 2/130 (1%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE N+ DG KW TLEH G F Y+ P +Y+G L EE ATFYA Sbjct: 66 WKWWEEENRNDGN-KWLTLEHKGPVFTEPYKRLPANVRFLYDGKPFQLSKETEEAATFYA 124 Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479 L + F NFF DFR L + K+I KC+F I + E K+ A Sbjct: 125 KMLNHECCRNRIFYRNFFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNKRLAAT 183 Query: 480 KAQTTAERKE 509 K + A+RK+ Sbjct: 184 KEEKLAKRKK 193 [205][TOP] >UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax RepID=A5KB33_PLAVI Length = 931 Score = 82.8 bits (203), Expect = 2e-14 Identities = 51/154 (33%), Positives = 81/154 (52%), Gaps = 7/154 (4%) Frame = +3 Query: 108 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 284 EN + RWWE ++TD V+W LEH G+ F P Y H P+ Y+ ++L L AEE+ Sbjct: 170 ENFEPINRWWEKIDHQTD--VQWHYLEHRGLIFSPPYVQHNIPIFYKSIKLQLNEKAEEL 227 Query: 285 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 446 AT++ S + +D+ KEKF NFF F L + + L+K D S + + Sbjct: 228 ATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDFMPI 287 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 548 +D K + EK +T E++E ++ +E+ +T Sbjct: 288 KDHLVKLREEKLNRTKEEKEEEKKLRSEKELPYT 321 [206][TOP] >UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1 Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7 Length = 879 Score = 82.4 bits (202), Expect = 2e-14 Identities = 49/164 (29%), Positives = 84/164 (51%), Gaps = 2/164 (1%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 K K++++ K +D+ + A + GA E + +G VKW L Sbjct: 339 KTKSKKKSKDTKKDKKDKKDTSRSKAKTGRGAKETPHPEG--------------VKWMFL 384 Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356 EH G F P YEP + Y+G E+ L AEEVA FYA ++ D+ K+ F +NF+ Sbjct: 385 EHTGPLFAPPYEPLPNSVKFFYDGEEMKLSEEAEEVAGFYARMIEHDYTTKDVFNNNFYR 444 Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488 D++ ++ + A +I ++KC+F +I A+ + + ++KA K + Sbjct: 445 DWKKVMTHEEKA-IIKDMKKCNFKQIHAYYQRKSEERKAMSKEE 487 [207][TOP] >UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI Length = 557 Score = 82.4 bits (202), Expect = 2e-14 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 2/130 (1%) Frame = +3 Query: 162 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335 +VKW TLEHNG FP YE P +Y+ + L AEEVATFYA L T V + Sbjct: 65 KVKWQTLEHNGPLFPGAYERLPENVHFLYDNCPIELTEQAEEVATFYAKVLGTPFVELSE 124 Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515 F NFF DFR+ L+ + TS + C+F +I +LE+++ + ++ + Sbjct: 125 FNENFFKDFRSCLS-VEQRLHFTSFDLCNFQKIHQYLEEQQEARSQQELEEDERYGYCYI 183 Query: 516 EAEAERVRQF 545 + E R+ QF Sbjct: 184 DGERHRINQF 193 [208][TOP] >UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1 Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO Length = 886 Score = 82.0 bits (201), Expect = 3e-14 Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 10/192 (5%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182 +VK E+++A K + T+ + + EN + RWWE + + +W L Sbjct: 160 RVKEEKKIAN---KVKKETVKKPKK----IPKKSEENFEPINRWWEKIDD-QSDTQWNYL 211 Query: 183 EHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADF 362 EH G+ F P Y H P+ Y+ +++ L P AEE+AT++ S + TD+ K+KF NFF F Sbjct: 212 EHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELATYWCSVIGTDYCTKDKFILNFFKTF 271 Query: 363 RALLADTKFAK----------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512 L + I++ + DF I+ HL K + E+ +T E++E Sbjct: 272 INNLEKDNIIRRENENKIKNGDISNFKFIDFMTIKEHL----IKLREERLNKTKEEKEEE 327 Query: 513 REAEAERVRQFT 548 ++ E+ +T Sbjct: 328 KKIRMEKELPYT 339 [209][TOP] >UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7 Length = 839 Score = 81.6 bits (200), Expect = 3e-14 Identities = 50/154 (32%), Positives = 81/154 (52%), Gaps = 7/154 (4%) Frame = +3 Query: 108 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 284 EN + RWWE ++TD ++W LEH G+ F P Y H P+ Y+ +++ L +EE+ Sbjct: 136 ENFEPINRWWEKIDDQTD--IQWNYLEHRGLIFSPPYVQHHVPIFYKSIKIELNAKSEEL 193 Query: 285 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 446 AT++ S + +D+ KEKF NFF F L + K T L+K D S + + Sbjct: 194 ATYWCSAIGSDYCTKEKFILNFFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMPI 253 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 548 +D K + EK +T E++E ++ E+ +T Sbjct: 254 KDHLLKLREEKLNKTKEEKEEEKKMRMEKELPYT 287 [210][TOP] >UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi RepID=Q4XMK5_PLACH Length = 429 Score = 80.5 bits (197), Expect = 7e-14 Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 13/147 (8%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 287 EN + RWWE + + +W LEH G+ F P Y H P+ Y+ +++ L P AEE+A Sbjct: 163 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELA 221 Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 437 T++ S + TD+ K+KF NFF F L + I++ + DF I+ Sbjct: 222 TYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDFMTIK 281 Query: 438 AH---LEDEKAKKKAEKKAQTTAERKE 509 H L DE+ K E+K + R E Sbjct: 282 EHLIKLRDERLNKTKEEKEEDKKIRME 308 [211][TOP] >UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L6G4_PLAKH Length = 924 Score = 80.5 bits (197), Expect = 7e-14 Identities = 49/149 (32%), Positives = 78/149 (52%), Gaps = 7/149 (4%) Frame = +3 Query: 108 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 284 EN + RWWE ++TD ++W LEH G+ F P Y H P+ Y+ ++L L AEE+ Sbjct: 170 ENFEPINRWWEKIDHQTD--IQWHYLEHRGLIFSPPYVQHHIPIFYKSIKLELNEKAEEL 227 Query: 285 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 446 AT++ S + +D+ KEKF NFF F L + L+K D S + + Sbjct: 228 ATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDFMPI 287 Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAER 533 +D K + EK +T E++E ++ +E+ Sbjct: 288 KDHLVKLREEKLNRTKEEKEEEKKLRSEK 316 [212][TOP] >UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE Length = 725 Score = 80.1 bits (196), Expect = 1e-13 Identities = 51/144 (35%), Positives = 72/144 (50%), Gaps = 14/144 (9%) Frame = +3 Query: 120 GGFR-----WWEAGNKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLP 266 GGF+ WWE N + E + W LEH+GV FPP Y+ H LIY G + L Sbjct: 17 GGFQARSHNWWEEANPEESEEEEQQGQEWRYLEHHGVLFPPFYKRHNVGLIYNGKLITLT 76 Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446 EE+ T++A + + + KE +R NF + L TKF L+K DF++I HL Sbjct: 77 EEQEELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIREHL 129 Query: 447 EDE---KAKKKAEKKAQTTAERKE 509 E + + K E+K Q ER + Sbjct: 130 EQQRLLRLNKSDEQKKQEKLERDQ 153 [213][TOP] >UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA Length = 909 Score = 79.7 bits (195), Expect = 1e-13 Identities = 45/119 (37%), Positives = 66/119 (55%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 KWTTL HNGV FPP Y+PHG ++Y+ + L EEV ++ T+++ K FR N Sbjct: 350 KWTTLVHNGVIFPPPYKPHGVKMLYKESPVDLTLNQEEVHMIAVMQILTEYLTKPVFREN 409 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524 D++ +L +I +L+ CDF+ I E + K EKK Q +AE K+A + E Sbjct: 410 VMNDWKIILGRN---HIIKNLDDCDFTPIY-----EWFRLKKEKKKQMSAEEKKAVKEE 460 [214][TOP] >UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei RepID=Q4YYG2_PLABE Length = 805 Score = 79.7 bits (195), Expect = 1e-13 Identities = 48/157 (30%), Positives = 78/157 (49%), Gaps = 10/157 (6%) Frame = +3 Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 287 EN + RWWE + + +W LEH G+ F P Y H P+ Y+ +++ L P AEE+A Sbjct: 133 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSVKIELNPKAEELA 191 Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 437 T++ S + TD+ KEKF NFF F L + I++ + DF I+ Sbjct: 192 TYWCSVIGTDYCTKEKFILNFFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDFMTIK 251 Query: 438 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 548 +L K + E+ +T E++E ++ E+ +T Sbjct: 252 ENL----IKLREERLNKTKEEKEEEKKIRMEKELPYT 284 [215][TOP] >UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax adhaerens RepID=B3S6N7_TRIAD Length = 560 Score = 79.7 bits (195), Expect = 1e-13 Identities = 53/140 (37%), Positives = 66/140 (47%), Gaps = 4/140 (2%) Frame = +3 Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL 308 WE K D VKW TLEH G P YE P Y+G L EE A FYA L Sbjct: 1 WEEDTK-DNSVKWKTLEHKGPLLAPPYERLPSNVQFYYDGQTFPLSDKTEEAAGFYAKML 59 Query: 309 QTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKK 482 D+ K+ F NF+ DFR + A+ KV + KCDFS+I E K KAE++ Sbjct: 60 DHDYTQKKIFNDNFWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EYYKMKAEER 111 Query: 483 AQTTAERKEAREAEAERVRQ 542 + E K + E E + Q Sbjct: 112 RNMSKEEKNKLKKENEELMQ 131 [216][TOP] >UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=O17966-2 Length = 734 Score = 79.0 bits (193), Expect = 2e-13 Identities = 55/180 (30%), Positives = 90/180 (50%), Gaps = 5/180 (2%) Frame = +3 Query: 6 VKAERRVAGGKAKTEDRTLSP---GRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176 VK ++R + G K++ T G+ + E+ + + WW+ K G VKW Sbjct: 130 VKPQKRKSKGAEKSKPSTSKKDAGGKKEPPKKKVKKEEDIEDIWEWWKEEKKPAG-VKWN 188 Query: 177 TLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNF 350 +L+H G F P Y P Y G ++ L EE+A FYA L ++ KE F NF Sbjct: 189 SLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYAGVLDHEYSTKEAFNKNF 248 Query: 351 FADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530 D+R ++ + + I L+KCDF I+A+ ++++ +KA K + + KE +EAE + Sbjct: 249 MKDWRKVMT-VEERERIHDLKKCDFRAIDAYQKEQREIRKAMTK-EEKLKIKEEKEAEVK 306 [217][TOP] >UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL Length = 806 Score = 79.0 bits (193), Expect = 2e-13 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 5/181 (2%) Frame = +3 Query: 3 KVKAERRVAGGKAKTEDRTLSP---GRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKW 173 K K ++R + G K++ T G+ + E+ + + WW+ K G VKW Sbjct: 201 KAKKKKRKSKGAEKSKPSTSKKDAGGKKEPPKKKVKKEEDIEDIWEWWKEEKKPAG-VKW 259 Query: 174 TTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347 +L+H G F P Y P Y G ++ L EE+A FYA L ++ KE F N Sbjct: 260 NSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYAGVLDHEYSTKEAFNKN 319 Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527 F D+R ++ + + I L+KCDF I+A+ ++++ +KA K + + KE +EAE Sbjct: 320 FMKDWRKVMT-VEERERIHDLKKCDFRAIDAYQKEQREIRKAMTK-EEKLKIKEEKEAEV 377 Query: 528 E 530 + Sbjct: 378 K 378 [218][TOP] >UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187DC43 Length = 343 Score = 78.6 bits (192), Expect = 3e-13 Identities = 43/104 (41%), Positives = 60/104 (57%), Gaps = 2/104 (1%) Frame = +3 Query: 240 YEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLE 413 ++G L+LPP +EEVA FYA+ ++TDH F NFF D+ +L D I T + Sbjct: 6 HDGKVLNLPPESEEVAGFYAALIETDHAQDAAFNKNFFEDWLKVLQDHPPCNGIKATDFD 65 Query: 414 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQF 545 KCDF + + E EKAKKKA A+ +K+ EAEA+ +F Sbjct: 66 KCDFRPMYEYFEAEKAKKKATSAAEKKEIKKQKDEAEAKYTHRF 109 [219][TOP] >UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE Length = 596 Score = 78.2 bits (191), Expect = 4e-13 Identities = 50/144 (34%), Positives = 73/144 (50%), Gaps = 14/144 (9%) Frame = +3 Query: 120 GGFR-----WWEAGNKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLP 266 GGF+ WWE N + E + W LEH+GV FPP Y+ H LIY G + L Sbjct: 17 GGFQARSHNWWEEANPEESEEEEQQGQEWRYLEHHGVLFPPFYKRHNVGLIYNGKLITLT 76 Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446 EE+ T++A + + + KE +R NF + L TKF L+K DF++I+ +L Sbjct: 77 EEQEELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIKEYL 129 Query: 447 EDE---KAKKKAEKKAQTTAERKE 509 E + + K E+K Q ER + Sbjct: 130 EQQRLLRLNKSDEQKKQEKLERDQ 153 [220][TOP] >UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO Length = 555 Score = 76.3 bits (186), Expect = 1e-12 Identities = 44/128 (34%), Positives = 66/128 (51%), Gaps = 2/128 (1%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFR 341 KW TL HNG FP ++E P Y+ + L AEEVATFYA ++T V +F Sbjct: 64 KWQTLRHNGPCFPADHERLPADVKFYYDNCPVELTEQAEEVATFYAKLMKTAFVQMREFN 123 Query: 342 SNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521 NFF +FR+ L++ + + IT E C+F I +LE ++ +K + + Sbjct: 124 QNFFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLECQREDEKERIAEENKLYGYCLVDG 182 Query: 522 EAERVRQF 545 E+ R+ QF Sbjct: 183 ESRRITQF 190 [221][TOP] >UniRef100_Q3ULF5 Putative uncharacterized protein (Fragment) n=1 Tax=Mus musculus RepID=Q3ULF5_MOUSE Length = 291 Score = 75.1 bits (183), Expect = 3e-12 Identities = 37/82 (45%), Positives = 47/82 (57%), Gaps = 2/82 (2%) Frame = +3 Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299 ++WWE +G +KW LEH G F P YEP Y+G + L P AEEVATF+A Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263 Query: 300 SKLQTDHVLKEKFRSNFFADFR 365 L ++ KE FR NFF D+R Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWR 285 [222][TOP] >UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PY85_MALGO Length = 877 Score = 73.2 bits (178), Expect = 1e-11 Identities = 46/120 (38%), Positives = 57/120 (47%), Gaps = 4/120 (3%) Frame = +3 Query: 159 GEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332 GE +WTTL H G FP Y P L Y+G + LPP +EEVA FYA KL++ H Sbjct: 118 GEQRWTTLIHKGPKFPEPYTPLPKDVMLKYDGHPVPLPPESEEVAMFYAVKLESQHASNP 177 Query: 333 KFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 F NFF DF L K I EK DF + + K + KK+ + RK Sbjct: 178 IFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSMRK 237 [223][TOP] >UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1 RepID=A9A2H9_NITMS Length = 551 Score = 73.2 bits (178), Expect = 1e-11 Identities = 49/122 (40%), Positives = 66/122 (54%), Gaps = 4/122 (3%) Frame = +3 Query: 165 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344 +KW TL+H G+ FPP YE G + +G ++ L EE+ +A K T + + F+ Sbjct: 1 MKWKTLQHKGILFPPAYEAQGIKIKIKGEKVDLNLDQEEMIYQWAKKKDTPYAQDKVFQK 60 Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK----KAEKKAQTTAERKEA 512 NF ADF L D+KF K+ S E DFS ++ EK K K EKKA A+RKE Sbjct: 61 NFTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEMMTKEEKKA-IAAKRKEL 116 Query: 513 RE 518 RE Sbjct: 117 RE 118 [224][TOP] >UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum RepID=A0RU10_CENSY Length = 519 Score = 72.4 bits (176), Expect = 2e-11 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 3/121 (2%) Frame = +3 Query: 165 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344 + W TL+H+G++FPPE+E GF + +G +++L P EE+A +A K T + + F+ Sbjct: 1 MNWKTLQHSGIHFPPEHEVKGFKIKVKGKQVNLTPLQEEMAYQWAKKKDTPYAQDKVFQK 60 Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK---KAEKKAQTTAERKEAR 515 NF DF L K + DFS ++ EK KK E+K + A+RKE R Sbjct: 61 NFARDFAKELGIKLLYKDL------DFSEAYRLVDMEKDKKDMMTKEEKKEIAAKRKEIR 114 Query: 516 E 518 E Sbjct: 115 E 115 [225][TOP] >UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA Length = 1019 Score = 71.6 bits (174), Expect = 3e-11 Identities = 47/132 (35%), Positives = 63/132 (47%), Gaps = 5/132 (3%) Frame = +3 Query: 159 GEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332 GE KW L H G FP Y+P L Y+G + LP EE+A FYA KL+T H Sbjct: 159 GEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNA 218 Query: 333 KFRSNFFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA-QTTAER 503 F NFF DF+ L + I S +K DF + + K + KKA +A + Sbjct: 219 IFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARK 278 Query: 504 KEAREAEAERVR 539 +E E +AE + Sbjct: 279 REIEERKAEETK 290 [226][TOP] >UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN Length = 240 Score = 70.9 bits (172), Expect = 6e-11 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 2/103 (1%) Frame = +3 Query: 168 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFR 341 KWTTL HNG F Y+ P YE + L L P AEE+AT YA + + + + F Sbjct: 18 KWTTLSHNGPLFVDHYQALPKEVAFYYEDLPLKLNPTAEELATLYAKFMNSPLAITDTFN 77 Query: 342 SNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK 470 NFF DF++ L+ + I S E CDF++I +++ ++ ++ Sbjct: 78 ENFFKDFQSHLS-RALRRQILSFELCDFTKIAFYIQGQQGVQR 119 [227][TOP] >UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH Length = 713 Score = 70.1 bits (170), Expect = 1e-10 Identities = 38/118 (32%), Positives = 61/118 (51%) Frame = +3 Query: 156 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335 + ++KW LEH+GV FP ++ H Y+G + L EE+AT+++ L TD K K Sbjct: 131 NSDIKWKYLEHHGVLFPDYWQKHNVRPRYDGKPIDLNLLQEEMATYWSQTLGTDWEHKPK 190 Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509 +R NF F K +K DF+ I+ HLE++K +K K + E+++ Sbjct: 191 YRENFSKQFLDTFGKDKGK---YDFDKFDFTPIKIHLEEQKEIRKNRSKEEKNQEKQK 245 [228][TOP] >UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio RepID=UPI0001A2BD10 Length = 349 Score = 65.9 bits (159), Expect = 2e-09 Identities = 58/192 (30%), Positives = 84/192 (43%), Gaps = 12/192 (6%) Frame = +3 Query: 3 KVKAERRVAGGKAK-TEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179 KVK +++ K K +D+ G+ + E D ++WWE G D VKW++ Sbjct: 79 KVKKDKKDEKKKEKGKKDKNDEEGKKEKGKKEDKKEEESDK-WKWWEEGKSCDA-VKWSS 136 Query: 180 LEHNGVYFPPEYE--PHGFPLIYEG---------MELHLPPAAEEVATFYASKLQTDHVL 326 LEH G YF P+YE P Y+G + LH P T Y L Sbjct: 137 LEHKGPYFAPDYEPLPANICFYYDGNNSERTAATLLLHSDPDLISDYTVYVCVL------ 190 Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506 FR F D + + + + K+IT+L KCDF+ I + +K EKK T K Sbjct: 191 ---FRMFFACDCQEMTKEER--KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----K 237 Query: 507 EAREAEAERVRQ 542 E + EA R+ + Sbjct: 238 EVLKDEAARLME 249 [229][TOP] >UniRef100_UPI000194EAF8 PREDICTED: similar to rCG63558, partial n=1 Tax=Taeniopygia guttata RepID=UPI000194EAF8 Length = 79 Score = 56.6 bits (135), Expect = 1e-06 Identities = 32/85 (37%), Positives = 47/85 (55%) Frame = +3 Query: 255 LHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI 434 + L AEEVATF+A L ++ KE FR NFF D+R + + ITSL KCDF+ + Sbjct: 1 MKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHM 59 Query: 435 EAHLEDEKAKKKAEKKAQTTAERKE 509 + K ++E + Q + E K+ Sbjct: 60 SQYF-----KAQSEARKQMSKEEKQ 79 [230][TOP] >UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis thaliana RepID=Q8RX06_ARATH Length = 514 Score = 56.6 bits (135), Expect = 1e-06 Identities = 35/91 (38%), Positives = 53/91 (58%), Gaps = 1/91 (1%) Frame = +3 Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 452 EEVAT +A +TD+ K +FR NF+ D+R LL VI L+ CDF+ I E HLE+ Sbjct: 4 EEVATMFAVMRETDYYTKPQFRENFWNDWRRLLGK---KHVIQKLDDCDFTPIYEWHLEE 60 Query: 453 EKAKKKAEKKAQTTAERKEAREAEAERVRQF 545 K +KK +T E+K +E + ++ ++ Sbjct: 61 -----KEKKKQMSTEEKKALKEEKMKQEEKY 86 [231][TOP] >UniRef100_C5KK36 Putative uncharacterized protein n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5KK36_9ALVE Length = 479 Score = 56.2 bits (134), Expect = 2e-06 Identities = 60/154 (38%), Positives = 70/154 (45%), Gaps = 2/154 (1%) Frame = +1 Query: 94 GPPKGRMETAAFGGGKRETRRMGRSSGPLSNT-TASTFRPSMSRTGFRLSTKAWSCICLR 270 G +GR T +R TRR RSS S T S+ R S R G R + +A S R Sbjct: 294 GGRRGRRRTRRAKSSRRRTRRRTRSSARSSRRRTRSSARSSGGRRGRRRTRRAKSSR-RR 352 Query: 271 RRKRLPPFMRPSYRRTMC*RRSSDPTSSRTSEPSWR-TPSLPR*SPAWKSVTLVGSRRT* 447 R+R R S RRT RSS S R + S R T S R + + + T RRT Sbjct: 353 TRRRTRSSARSSRRRTRSSARSSARNSRRRTRSSRRRTRSNRRRTRSSRRRTRSSRRRT- 411 Query: 448 RMKRRRRRRRRRRRRRPSARRPVRLRPSVFVSSR 549 R RRR R RRR R S RR R S SSR Sbjct: 412 RSSRRRTRSSRRRSARSSRRRTRRRTRSSARSSR 445 [232][TOP] >UniRef100_B8CC90 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8CC90_THAPS Length = 178 Score = 55.5 bits (132), Expect = 3e-06 Identities = 24/57 (42%), Positives = 33/57 (57%) Frame = +3 Query: 111 NGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 281 +G ++WW GN +W +EH GV FP Y PHG ++Y+G E+ L PA EE Sbjct: 122 HGMQAYQWWN-GNDPPKGCQWVKMEHAGVSFPEGYVPHGVKMLYDGTEVELGPAEEE 177 [233][TOP] >UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio RepID=UPI000176075D Length = 531 Score = 54.3 bits (129), Expect = 6e-06 Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 1/93 (1%) Frame = +3 Query: 243 EGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCD 422 E ++L LP AEEVA ++A L ++ KE FR+NFF D+R + + ++I L+KCD Sbjct: 11 EPVKLSLP--AEEVALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCD 67 Query: 423 FSRIEA-HLEDEKAKKKAEKKAQTTAERKEARE 518 F + A H E +A+K K+ + KEA + Sbjct: 68 FGELHAMHKEKVEARKNLSKEEKLV--NKEANQ 98