AU195610 ( PFL077g02_r )

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[1][TOP]
>UniRef100_Q54RC3 DNA topoisomerase 1 n=1 Tax=Dictyostelium discoideum
           RepID=TOP1_DICDI
          Length = 893

 Score =  134 bits (338), Expect = 3e-30
 Identities = 63/147 (42%), Positives = 92/147 (62%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 281
           E E  +G  +WW+  +  D   KWTTL HNG  FPP Y PHG   +Y+G  + L P  EE
Sbjct: 289 EEEEEEGVNKWWDKEDDEDDGTKWTTLIHNGPVFPPAYVPHGIKFMYDGKVVKLTPKQEE 348

Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 461
           VATFYA+ L+TDHV K+ F+ NFF +F+ LL   +  +++  ++KCDFS I  HL+ +K 
Sbjct: 349 VATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQ-KEIVKKMDKCDFSHIHTHLKTKKE 407

Query: 462 KKKAEKKAQTTAERKEAREAEAERVRQ 542
           ++KA  K     E K+A  AE +++++
Sbjct: 408 QRKARSK-----EEKDAETAEKKKIQE 429

[2][TOP]
>UniRef100_A5E508 DNA topoisomerase I n=1 Tax=Lodderomyces elongisporus
           RepID=A5E508_LODEL
          Length = 849

 Score =  134 bits (337), Expect = 4e-30
 Identities = 77/187 (41%), Positives = 108/187 (57%), Gaps = 7/187 (3%)
 Frame = +3

Query: 3   KVKAE----RRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVK 170
           KVKAE    +     + K E    S    +G      + E  D G++WWEA ++ DGE+K
Sbjct: 168 KVKAEPSTKKTTKASQVKKETSVKSETPESGDGGDDDDEEEEDAGYKWWEAQDEHDGEIK 227

Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344
           WT+LEHNGV FPPEYE  P    L Y+G  ++LP  AEEVA F+ + ++TDH     F+ 
Sbjct: 228 WTSLEHNGVMFPPEYEPLPSHVKLYYDGKPVNLPVEAEEVAGFFGAMVETDHAKNPVFQK 287

Query: 345 NFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521
           NFF DF+ +L ++    V I   EK DFS+I A+ E    KK+ EKKA +  E+K  +E 
Sbjct: 288 NFFNDFKEVLKESGGCNVDIKEFEKMDFSKIYAYYE----KKREEKKAMSREEKKRLKE- 342

Query: 522 EAERVRQ 542
           E +R+ +
Sbjct: 343 EKDRIEE 349

[3][TOP]
>UniRef100_UPI000187E0BD hypothetical protein MPER_05582 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187E0BD
          Length = 265

 Score =  133 bits (335), Expect = 7e-30
 Identities = 75/183 (40%), Positives = 102/183 (55%), Gaps = 4/183 (2%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188
           K ++R    K + E+ T SP +  G      E E  +  ++WWE  N+ D  VKWTTLEH
Sbjct: 33  KPKKRAPKAKKEQEETTSSPTKGKGKK--RKEDEEQEDVYKWWENNNE-DSSVKWTTLEH 89

Query: 189 NGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADF 362
           NGV FPP YEP      + Y+G  L+LPP +EEVA FYA+ ++TDH     F  NFF D+
Sbjct: 90  NGVIFPPPYEPLPSNVKMKYDGKVLNLPPESEEVAGFYAALIETDHAQDATFNKNFFEDW 149

Query: 363 RALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536
             +L D   +    +T  +KCDF  +  + E EKAKKKA   A+    +K+  EAEA+  
Sbjct: 150 LKVLQDHPPRNGIKVTDFDKCDFRPMYEYFEAEKAKKKAMSAAEKKEIKKQKDEAEAKYT 209

Query: 537 RQF 545
             F
Sbjct: 210 HCF 212

[4][TOP]
>UniRef100_B9WIH6 DNA topoisomerase, putative n=1 Tax=Candida dubliniensis CD36
           RepID=B9WIH6_CANDC
          Length = 777

 Score =  126 bits (316), Expect = 1e-27
 Identities = 75/185 (40%), Positives = 100/185 (54%), Gaps = 4/185 (2%)
 Frame = +3

Query: 3   KVKAERRVAGG-KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179
           K K E + A   K K E ++ S  +A+      +E    D G++WWEA  +TD  +KW T
Sbjct: 103 KSKKESKTASSTKVKEEPKSQSDSQASVK----SETPEEDQGYKWWEANEETDDIIKWQT 158

Query: 180 LEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           LEHNGV FPP YE  P    L Y    ++LPP AEEVA FY + L+TDH     F+ NFF
Sbjct: 159 LEHNGVIFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 218

Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
            DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+K  +E + +
Sbjct: 219 NDFLEVLKECGGCGVEIKDFEKLDFSKMYAHFE----KLREEKKAMSKEEKKRIKEEKEK 274

Query: 531 RVRQF 545
               F
Sbjct: 275 EEEPF 279

[5][TOP]
>UniRef100_C5M985 DNA topoisomerase I n=1 Tax=Candida tropicalis MYA-3404
           RepID=C5M985_CANTT
          Length = 777

 Score =  125 bits (313), Expect = 3e-27
 Identities = 74/176 (42%), Positives = 99/176 (56%), Gaps = 15/176 (8%)
 Frame = +3

Query: 36  KAKTEDRTL--------SPGRAAGSPLGAAEGE-NGDGGFRWWEAGNKTDGEVKWTTLEH 188
           KAK E  TL        SP +    P  +   E   D G++WWEA  +T+G +KW TLEH
Sbjct: 102 KAKKEKSTLKKEPKSKESPTKLKKEPTKSETPEAEEDEGYKWWEATEETEGGIKWETLEH 161

Query: 189 NGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADF 362
           NGV FPPEYE  P    L Y+G  ++LPP AEEVA FY + L+TDH     F+ NFF DF
Sbjct: 162 NGVIFPPEYEPLPSHVKLYYDGKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDF 221

Query: 363 RALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERKEARE 518
             +L +     V I   EK DFS++ A+ E ++ +KKA   ++K +   ER +  E
Sbjct: 222 LEVLKECGGCGVEIKEFEKMDFSKMYAYYEQQREEKKALSRDEKKRLKEERDKFEE 277

[6][TOP]
>UniRef100_Q59XR0 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59XR0_CANAL
          Length = 780

 Score =  124 bits (311), Expect = 5e-27
 Identities = 76/186 (40%), Positives = 100/186 (53%), Gaps = 8/186 (4%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTT 179
           VK E +    K K E +T S  +A+      +E    D G++WWE   + +G+  +KW T
Sbjct: 106 VKKESKATSTKVKEESKTQSDSQASVK----SETPEEDQGYKWWEVNQEEEGDGYIKWQT 161

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           LEHNGV FPP YEP      L Y    ++LPP AEEVA FY + L+TDH     F+ NFF
Sbjct: 162 LEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 221

Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER---KEAREA 521
            DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+   KE +E 
Sbjct: 222 NDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEK 277

Query: 522 EAERVR 539
           E E  R
Sbjct: 278 EEEPYR 283

[7][TOP]
>UniRef100_Q00313 DNA topoisomerase 1 n=1 Tax=Candida albicans RepID=TOP1_CANAL
          Length = 778

 Score =  124 bits (311), Expect = 5e-27
 Identities = 76/186 (40%), Positives = 100/186 (53%), Gaps = 8/186 (4%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTT 179
           VK E +    K K E +T S  +A+      +E    D G++WWE   + +G+  +KW T
Sbjct: 104 VKKESKATSTKVKEESKTQSDSQASVK----SETPEEDQGYKWWEVNQEEEGDGYIKWQT 159

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           LEHNGV FPP YEP      L Y    ++LPP AEEVA FY + L+TDH     F+ NFF
Sbjct: 160 LEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 219

Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER---KEAREA 521
            DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+   KE +E 
Sbjct: 220 NDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEK 275

Query: 522 EAERVR 539
           E E  R
Sbjct: 276 EEEPYR 281

[8][TOP]
>UniRef100_Q59WV6 Likely DNA topoisomerase I n=1 Tax=Candida albicans
           RepID=Q59WV6_CANAL
          Length = 780

 Score =  123 bits (309), Expect = 8e-27
 Identities = 76/186 (40%), Positives = 100/186 (53%), Gaps = 8/186 (4%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGE--VKWTT 179
           VK E +    K K E +T S  +A+      +E    D G++WWE   + +G+  +KW T
Sbjct: 106 VKKESKATSTKVKEESKTQSDSQASVK----SETLEEDQGYKWWEVNQEEEGDGYIKWQT 161

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           LEHNGV FPP YEP      L Y    ++LPP AEEVA FY + L+TDH     F+ NFF
Sbjct: 162 LEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFF 221

Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER---KEAREA 521
            DF  +L +     V I   EK DFS++ AH E    K + EKKA +  E+   KE +E 
Sbjct: 222 NDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFE----KLREEKKAMSREEKKRIKEEKEK 277

Query: 522 EAERVR 539
           E E  R
Sbjct: 278 EEEPYR 283

[9][TOP]
>UniRef100_C5LJG7 DNA topoisomerase, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5LJG7_9ALVE
          Length = 551

 Score =  120 bits (301), Expect = 7e-26
 Identities = 61/129 (47%), Positives = 82/129 (63%)
 Frame = +3

Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           RWWE  +  D   KW+ LEH+G+ F P YEPHG  ++Y+G  + LPP AEEVATF+A  L
Sbjct: 83  RWWEK-DPEDNAAKWSYLEHHGMIFTPPYEPHGVKMLYKGEPIDLPPEAEEVATFFAQTL 141

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
            TD   KEKF++NF+ADF+A L     +K IT L+ CDF  I+ +L+     KKA  K +
Sbjct: 142 GTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLDKRSEAKKARTKEE 200

Query: 489 TTAERKEAR 515
             AE++  R
Sbjct: 201 KEAEKEAKR 209

[10][TOP]
>UniRef100_C5L755 DNA topoisomerase I, putative n=1 Tax=Perkinsus marinus ATCC 50983
           RepID=C5L755_9ALVE
          Length = 647

 Score =  120 bits (301), Expect = 7e-26
 Identities = 61/129 (47%), Positives = 82/129 (63%)
 Frame = +3

Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           RWWE  +  D   KW+ LEH+G+ F P YEPHG  ++Y+G  + LPP AEEVATF+A  L
Sbjct: 83  RWWEK-DPEDNAAKWSYLEHHGMIFTPPYEPHGVKMLYKGEPIDLPPEAEEVATFFAQTL 141

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
            TD   KEKF++NF+ADF+A L     +K IT L+ CDF  I+ +L+     KKA  K +
Sbjct: 142 GTDWCQKEKFQNNFWADFQAKLPKELKSK-ITKLKDCDFEPIKNYLDKRSEAKKARTKEE 200

Query: 489 TTAERKEAR 515
             AE++  R
Sbjct: 201 KEAEKEAKR 209

[11][TOP]
>UniRef100_Q0UUB0 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum
           RepID=Q0UUB0_PHANO
          Length = 887

 Score =  120 bits (300), Expect = 8e-26
 Identities = 73/155 (47%), Positives = 84/155 (54%), Gaps = 10/155 (6%)
 Frame = +3

Query: 96  AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 269
           AAE E  +  +RWWE   K DG  KW TLEHNGV FPPEY   P    LIY+G+ + L P
Sbjct: 234 AAEDEEEE--YRWWEDTAKGDGSKKWDTLEHNGVVFPPEYVPLPKNVKLIYDGIPVTLQP 291

Query: 270 AAEEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDF 425
            AEE ATFY S L + H V    F  NFF DF A+L  T   K        I   EKCDF
Sbjct: 292 EAEEAATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKDGKTVKIKKFEKCDF 351

Query: 426 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
             I  H E ++A KKA   A+  A + E   AEAE
Sbjct: 352 KPIFEHFEADRAAKKALPAAEKKALKAEKDAAEAE 386

[12][TOP]
>UniRef100_B6QNQ2 Topoisomerase I n=1 Tax=Penicillium marneffei ATCC 18224
           RepID=B6QNQ2_PENMQ
          Length = 860

 Score =  120 bits (300), Expect = 8e-26
 Identities = 77/190 (40%), Positives = 101/190 (53%), Gaps = 16/190 (8%)
 Frame = +3

Query: 6   VKAERRVAGGKA-KTEDRT-LSPGRAAGSPLGA----AEGENGDGGFRWWEAGNKTDGEV 167
           VK E  V   KA K+E  T    G+   +P+ A     EG   +  +RWWE   K DG +
Sbjct: 169 VKTENGVGAKKAIKSEPSTPAKKGKGKATPVKAESEDVEGAEEEEEYRWWEDPTKGDGTI 228

Query: 168 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKF 338
           KW TLEHNGV FPPEYE  P    + Y+G+ + L P AEEVA F+ + L + H V    F
Sbjct: 229 KWNTLEHNGVVFPPEYEPLPKNVKMKYDGVPVVLHPEAEEVAGFFGAMLNSTHNVENPTF 288

Query: 339 RSNFFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 497
           + NFF DF+A+L  T  AK        I   +KCDF  I  + E ++ +KK    A+  A
Sbjct: 289 QKNFFEDFKAILKKTGGAKTQKGEPINIKEFKKCDFKPIFEYYEGKRLEKKNLSAAEKKA 348

Query: 498 ERKEAREAEA 527
            + E  EAEA
Sbjct: 349 LKAERDEAEA 358

[13][TOP]
>UniRef100_Q94705 DNA topoisomerase I n=1 Tax=Physarum polycephalum
           RepID=Q94705_PHYPO
          Length = 1015

 Score =  119 bits (298), Expect = 1e-25
 Identities = 72/178 (40%), Positives = 99/178 (55%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188
           K E +  GG+AK + +               EGE G+  ++WWE     DG+ +WT+L H
Sbjct: 373 KKEVKEEGGEAKKKGKK-------------KEGE-GEEEWKWWEEEALPDGK-RWTSLVH 417

Query: 189 NGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRA 368
           NGV F   Y  HG    Y+G  ++L P AEEVATFYA  L+TD+  KE F +NF++DFR 
Sbjct: 418 NGVVFVEPYVAHGVKFYYDGKPINLSPEAEEVATFYAKYLETDYPKKENFNTNFWSDFRT 477

Query: 369 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
            L   +  KVI    K DF+ I  +L ++K     E KA  TAE K+A +AE E++ Q
Sbjct: 478 YLTPEQ-KKVIKDFSKADFTHIHKYLVEQK-----ELKANRTAEEKKAEKAEKEKLLQ 529

[14][TOP]
>UniRef100_A3LUX2 DNA topoisomerase I n=1 Tax=Pichia stipitis RepID=A3LUX2_PICST
          Length = 780

 Score =  119 bits (298), Expect = 1e-25
 Identities = 67/148 (45%), Positives = 88/148 (59%), Gaps = 3/148 (2%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281
           E+ D G++WWEA +  DG  KW TLEHNGV FPPEYEP      L Y+G  + L   AEE
Sbjct: 137 EDEDEGYKWWEAED-VDGVQKWETLEHNGVLFPPEYEPLPSHVKLYYDGKPVKLSLEAEE 195

Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEK 458
           VA FY + L+TDH     F+ NFF DF  ++ +T  + V I   EK DFS+I AH E   
Sbjct: 196 VAGFYGAMLETDHAKNPVFQKNFFGDFLDVIKETNGSDVEIKDFEKLDFSKIFAHFE--- 252

Query: 459 AKKKAEKKAQTTAERKEAREAEAERVRQ 542
             K  E+K   T ++K+A + E ER+ +
Sbjct: 253 --KLREEKKLLTKDQKKAMKEEKERIEE 278

[15][TOP]
>UniRef100_P07799 DNA topoisomerase 1 n=1 Tax=Schizosaccharomyces pombe
           RepID=TOP1_SCHPO
          Length = 814

 Score =  119 bits (297), Expect = 2e-25
 Identities = 61/141 (43%), Positives = 84/141 (59%), Gaps = 2/141 (1%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281
           E+ D  ++WW + N  D + KWTTLEHNGV F P YEP      LIY+G  ++LPP AEE
Sbjct: 175 EDEDEDYKWWTSENIDDTQ-KWTTLEHNGVIFAPPYEPLPKNVKLIYDGNPVNLPPEAEE 233

Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKA 461
           VA FYA+ L+TDH     F+ NFF DF  +  +  F   I    KCDF+++  H E ++ 
Sbjct: 234 VAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHNIKEFSKCDFTQMFHHFEQKRE 293

Query: 462 KKKAEKKAQTTAERKEAREAE 524
           +KK+  K Q  A +++  E E
Sbjct: 294 EKKSMPKEQKKAIKQKKDEEE 314

[16][TOP]
>UniRef100_Q6C7R2 YALI0D26103p n=1 Tax=Yarrowia lipolytica RepID=Q6C7R2_YARLI
          Length = 760

 Score =  118 bits (296), Expect = 2e-25
 Identities = 67/156 (42%), Positives = 94/156 (60%), Gaps = 9/156 (5%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLI--YEGMELHLPPAA 275
           E E  +  ++WWE  N+ D  +KW TLEH GV FPPEYEP    ++  Y+G  + LP AA
Sbjct: 113 ETEEAEDVYKWWENDNQDDS-IKWETLEHKGVMFPPEYEPLPKSVLMKYDGTPVVLPHAA 171

Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI 434
           EEVA F+ + L+TDH     F+ NFF DF+A+L ++  AK        I +  KCDFS +
Sbjct: 172 EEVAGFFGAMLETDHAKNPTFQKNFFNDFKAVLKESGGAKDKDGNNVQIKAFSKCDFSDM 231

Query: 435 EAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
            AH E    K + EKKA + AE+K A +AE +++ +
Sbjct: 232 YAHFE----KMREEKKAMSAAEKK-AIKAERDKIEE 262

[17][TOP]
>UniRef100_A8N6Y9 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea
           okayama7#130 RepID=A8N6Y9_COPC7
          Length = 863

 Score =  118 bits (296), Expect = 2e-25
 Identities = 73/181 (40%), Positives = 94/181 (51%), Gaps = 7/181 (3%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSP--GRAAGSPLGAAEGENGDGGFRWWEAGNKT-DGEVKW 173
           + K     A GK K E+   SP  G+         E E  +  F+WWEAG+   DG  KW
Sbjct: 200 EAKPSASKANGKVKKEEPA-SPVKGKGKKGKQKEEEEEEEEEVFKWWEAGDVNGDGTQKW 258

Query: 174 TTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
            TLEHNGVYFPP YE  P    + Y G ++ L   AEEVA FY + L+TDH     F  N
Sbjct: 259 ETLEHNGVYFPPPYEALPKHVKMKYNGKDVDLSIEAEEVAGFYGALLETDHAKDATFNKN 318

Query: 348 FFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521
           FF DF+ +L     +    IT+ E CDF  +  + E EKAK+KA    +  A +K+  E 
Sbjct: 319 FFTDFKKVLEKYPPRCGTKITTFELCDFRPMFEYFEAEKAKRKAMTNEEKKAAKKKKDEL 378

Query: 522 E 524
           E
Sbjct: 379 E 379

[18][TOP]
>UniRef100_B8MH68 Topoisomerase I n=1 Tax=Talaromyces stipitatus ATCC 10500
           RepID=B8MH68_TALSN
          Length = 864

 Score =  117 bits (293), Expect = 6e-25
 Identities = 74/189 (39%), Positives = 97/189 (51%), Gaps = 15/189 (7%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRT-LSPGRAAGSPLGA----AEGENGDGGFRWWEAGNKTDGEVK 170
           VK E  V   K K E  T +  G+   +P+       E    +  +RWWE   K DG +K
Sbjct: 174 VKTENGVGTKKIKAEPSTPVKKGKGKATPVKEESEDVEAAEEEEEYRWWEDPTKGDGTIK 233

Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFR 341
           WTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L + H V    F+
Sbjct: 234 WTTLEHNGVVFPPPYEPLPKNVKMKYDGIPVVLEPEAEEVAGFFGSMLNSTHNVENPTFQ 293

Query: 342 SNFFADFRALLADTKFAKV-------ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAE 500
            NFF DF+A+L  T  AK        I    KCDF  I  + + ++ +KKA   A+  A 
Sbjct: 294 KNFFDDFKAILKKTGGAKTQKGEPIDIKEFSKCDFKPIFEYYDAKRLEKKAMSAAEKKAL 353

Query: 501 RKEAREAEA 527
           + E   AEA
Sbjct: 354 KAEKDAAEA 362

[19][TOP]
>UniRef100_Q2URN8 DNA topoisomerase I n=1 Tax=Aspergillus oryzae RepID=Q2URN8_ASPOR
          Length = 881

 Score =  116 bits (291), Expect = 9e-25
 Identities = 77/194 (39%), Positives = 103/194 (53%), Gaps = 20/194 (10%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRT-----LSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDG 161
           K  +R +  K KTE ++     +  G A  +P+   E E  +      +RWWE   K DG
Sbjct: 188 KPVKRASTAKVKTEPKSAQSTPVKKGSAKATPVKKEESEEAEEAEEEEYRWWEDPTKGDG 247

Query: 162 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQ-TDHVLKE 332
            +KWTTLEHNGV FPP YE  P    + Y+G+ ++L P AEEVA F+ S L  T HV   
Sbjct: 248 TIKWTTLEHNGVVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNATQHVENP 307

Query: 333 KFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 491
            F+ NFF DF+ +L       D+K  KV I    KCDF  I A+ +     K+ EKK   
Sbjct: 308 TFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLP 363

Query: 492 TAERKEAR-EAEAE 530
            AE+K  + E +AE
Sbjct: 364 PAEKKRLKAEKDAE 377

[20][TOP]
>UniRef100_B8MY66 Topoisomerase I n=1 Tax=Aspergillus flavus NRRL3357
           RepID=B8MY66_ASPFN
          Length = 881

 Score =  116 bits (291), Expect = 9e-25
 Identities = 77/194 (39%), Positives = 103/194 (53%), Gaps = 20/194 (10%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRT-----LSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDG 161
           K  +R +  K KTE ++     +  G A  +P+   E E  +      +RWWE   K DG
Sbjct: 188 KPVKRASTAKVKTEPKSAQSTPVKKGSAKATPVKKEESEEAEEAEEEEYRWWEDPTKGDG 247

Query: 162 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQ-TDHVLKE 332
            +KWTTLEHNGV FPP YE  P    + Y+G+ ++L P AEEVA F+ S L  T HV   
Sbjct: 248 TIKWTTLEHNGVVFPPPYEPLPKDVKMKYDGVPVNLHPDAEEVAGFFGSMLNATQHVENP 307

Query: 333 KFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQT 491
            F+ NFF DF+ +L       D+K  KV I    KCDF  I A+ +     K+ EKK   
Sbjct: 308 TFQKNFFMDFKDILKKTGGATDSKGNKVDIKDFSKCDFQPIFAYYD----MKRLEKKNLP 363

Query: 492 TAERKEAR-EAEAE 530
            AE+K  + E +AE
Sbjct: 364 PAEKKRLKAEKDAE 377

[21][TOP]
>UniRef100_Q5KB99 Topoisomerase I n=1 Tax=Filobasidiella neoformans
           RepID=Q5KB99_CRYNE
          Length = 881

 Score =  115 bits (287), Expect = 3e-24
 Identities = 68/171 (39%), Positives = 89/171 (52%), Gaps = 4/171 (2%)
 Frame = +3

Query: 27  AGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFP 206
           A GKAK        G+         E E  +  ++WWE     DG  KWT LEHN V FP
Sbjct: 214 ARGKAKAATVKEEKGKKTKKE---KEEEEEEERYKWWEQDALGDGSSKWTVLEHNAVLFP 270

Query: 207 PEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLA- 377
           P Y P      + Y+G+ L LPP +EEVA F+ + L+TD+    KFR NFF DF+A++  
Sbjct: 271 PPYVPLPKNVKMKYDGVSLTLPPESEEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEK 330

Query: 378 -DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
              K    +  LEKCDF  +  + E EK KKKA  K +  A + E  + EA
Sbjct: 331 YPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKALTKEEKKAIKAEKDKLEA 381

[22][TOP]
>UniRef100_O59891 Topoisomerase I n=1 Tax=Cryptococcus neoformans var. neoformans
           RepID=O59891_CRYNE
          Length = 844

 Score =  115 bits (287), Expect = 3e-24
 Identities = 68/171 (39%), Positives = 89/171 (52%), Gaps = 4/171 (2%)
 Frame = +3

Query: 27  AGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFP 206
           A GKAK        G+         E E  +  ++WWE     DG  KWT LEHN V FP
Sbjct: 177 ARGKAKAAQVKEEKGKKTKKE---KEEEEEEEKYKWWEQDALGDGSSKWTVLEHNAVLFP 233

Query: 207 PEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLA- 377
           P Y P      + Y+G+ L LPP +EEVA F+ + L+TD+    KFR NFF DF+A++  
Sbjct: 234 PPYVPLPKDVKMKYDGVSLTLPPESEEVAGFFGALLETDYAQDAKFRENFFRDFKAIVEK 293

Query: 378 -DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
              K    +  LEKCDF  +  + E EK KKKA  K +  A + E  + EA
Sbjct: 294 YPPKEDVKVKKLEKCDFRPMFEYFEKEKEKKKALTKEEKKAIKAEKDKLEA 344

[23][TOP]
>UniRef100_C6HAF8 Topoisomerase I n=1 Tax=Ajellomyces capsulatus H143
           RepID=C6HAF8_AJECH
          Length = 909

 Score =  115 bits (287), Expect = 3e-24
 Identities = 72/187 (38%), Positives = 97/187 (51%), Gaps = 12/187 (6%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAA--GSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176
           KV A++     KA+  D      +AA         EGE+ +  +RWWE   K DG +KWT
Sbjct: 221 KVPAKKPSKAVKAEPADTKKMKAKAAVKNESSEELEGEDAEEEYRWWEDPAKGDGTIKWT 280

Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347
           TLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L + H V    F+ N
Sbjct: 281 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 340

Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           FF DF A + ++  AK        I S +KCDF  I  + E  + +KK+   A+    + 
Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYEAARLEKKSLPSAEKKRLKA 400

Query: 507 EAREAEA 527
           E  E EA
Sbjct: 401 EKDELEA 407

[24][TOP]
>UniRef100_C0NC53 Topoisomerase I n=1 Tax=Ajellomyces capsulatus G186AR
           RepID=C0NC53_AJECG
          Length = 909

 Score =  115 bits (287), Expect = 3e-24
 Identities = 72/187 (38%), Positives = 97/187 (51%), Gaps = 12/187 (6%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAA--GSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176
           KV A++     KA+  D      +AA         EGE+ +  +RWWE   K DG +KWT
Sbjct: 221 KVPAKKPSKAVKAEPADTKKMKAKAAVKNESSEELEGEDAEEEYRWWEDPAKGDGTIKWT 280

Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347
           TLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L + H V    F+ N
Sbjct: 281 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 340

Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           FF DF A + ++  AK        I S +KCDF  I  + E  + +KK+   A+    + 
Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAIKSFDKCDFKPIFEYYEAARLEKKSLPSAEKKRLKA 400

Query: 507 EAREAEA 527
           E  E EA
Sbjct: 401 EKDELEA 407

[25][TOP]
>UniRef100_C5FTA8 DNA topoisomerase 1 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FTA8_NANOT
          Length = 896

 Score =  114 bits (286), Expect = 4e-24
 Identities = 74/184 (40%), Positives = 97/184 (52%), Gaps = 15/184 (8%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRTLSPG-----RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKW 173
           KA  + AG  AKT   T +       +   S    AE E  +  +RWWE  +K DG +KW
Sbjct: 207 KAPAKKAGAAAKTTTATPAKKEKPSVKKEASEEVEAEEEEAEEEYRWWEDPSKGDGTIKW 266

Query: 174 TTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRS 344
           TTLEHNGV FPP YE  P    + Y G+ + L P AEEVA+ + + L + H V    F+ 
Sbjct: 267 TTLEHNGVVFPPPYEPLPKDVKMKYAGVPITLHPDAEEVASHFGTMLNSTHNVENPVFQK 326

Query: 345 NFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAER 503
           NFF DF+A++  T  AK        +    KCDF  I  H E    K +A+KKA T AE+
Sbjct: 327 NFFNDFQAIIKKTGGAKDPQGKPVQVKEFAKCDFVPIFEHHE----KLRAQKKAMTAAEK 382

Query: 504 KEAR 515
           K A+
Sbjct: 383 KAAK 386

[26][TOP]
>UniRef100_C1H484 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb01
           RepID=C1H484_PARBA
          Length = 900

 Score =  114 bits (286), Expect = 4e-24
 Identities = 76/186 (40%), Positives = 95/186 (51%), Gaps = 11/186 (5%)
 Frame = +3

Query: 3   KVKAERRVAG-GKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179
           KVKAE   A   KAKT+  +     A        E E G+  +RWWE   K DG +KWTT
Sbjct: 219 KVKAESTDAKISKAKTKKESSEEADAD------VEAEEGEEEYRWWEDPTKGDGTIKWTT 272

Query: 180 LEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNF 350
           LEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L + H V    F+ NF
Sbjct: 273 LEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKNF 332

Query: 351 FADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           F DF A +  +  AK        I S +KCDF  I    E  + +KKA   A+    + E
Sbjct: 333 FNDFTAYVKKSGGAKDPNGNSVAINSFDKCDFKPIFEFYEAARLEKKALPAAEKKRLKAE 392

Query: 510 AREAEA 527
             E EA
Sbjct: 393 KDELEA 398

[27][TOP]
>UniRef100_A6R590 Putative uncharacterized protein n=1 Tax=Ajellomyces capsulatus
           NAm1 RepID=A6R590_AJECN
          Length = 651

 Score =  114 bits (286), Expect = 4e-24
 Identities = 71/187 (37%), Positives = 97/187 (51%), Gaps = 12/187 (6%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAA--GSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176
           KV A++     KA+  D   +  +AA         E E+ +  +RWWE   K DG +KWT
Sbjct: 221 KVPAKKTSKAVKAEPADTKKTKAKAAVKNESSEELEAEDAEEEYRWWEDPAKGDGTIKWT 280

Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347
           TLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L + H V    F+ N
Sbjct: 281 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 340

Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           FF DF A + ++  AK        + S EKCDF  I  + E  + +KK+   A+    + 
Sbjct: 341 FFTDFTAYIKNSGGAKDPNGNPVAVKSFEKCDFKPIFEYYEAARLEKKSLPSAEKKRLKA 400

Query: 507 EAREAEA 527
           E  E EA
Sbjct: 401 EKDELEA 407

[28][TOP]
>UniRef100_B2WCA4 DNA topoisomerase 1 n=1 Tax=Pyrenophora tritici-repentis Pt-1C-BFP
           RepID=B2WCA4_PYRTR
          Length = 905

 Score =  114 bits (284), Expect = 6e-24
 Identities = 67/153 (43%), Positives = 82/153 (53%), Gaps = 10/153 (6%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275
           E  + +  +RWW+   K DG  KW TLEH GV FPPEYE  P    L+Y+G+ + L   A
Sbjct: 252 EAADEEDEYRWWDDPGKNDGTKKWDTLEHAGVVFPPEYEPLPKHVKLVYDGVPVTLHKDA 311

Query: 276 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431
           EEVATFY S L + H V    F  NFF DF A+L  T   K        I   EKCDF  
Sbjct: 312 EEVATFYGSMLNSTHNVENPTFNKNFFEDFTAILDKTGHGKDKNGNTIKIKKFEKCDFKP 371

Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
           I    + E+AKKKA   A+  A + E   AEA+
Sbjct: 372 IFEWFDAERAKKKALSAAEKKALKAEKEAAEAD 404

[29][TOP]
>UniRef100_Q2HDT9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HDT9_CHAGB
          Length = 907

 Score =  112 bits (281), Expect = 1e-23
 Identities = 69/168 (41%), Positives = 91/168 (54%), Gaps = 14/168 (8%)
 Frame = +3

Query: 63  SPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PH 224
           +P    G P+     EN +G     +RWW+A  K D  VKWTTLEH+GV FPPEYE  P 
Sbjct: 233 TPPDKGGKPVKDESKENSEGEDEEEYRWWDAPKKEDDSVKWTTLEHSGVLFPPEYERLPK 292

Query: 225 GFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-- 395
              L+Y+G  + L   AEEVATF+ S L  T +V    F+ NFFADF+ +L  T  AK  
Sbjct: 293 NVKLLYDGQPVDLHIEAEEVATFFGSMLHSTQNVENPVFQKNFFADFKDILKKTGGAKDK 352

Query: 396 -----VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
                 I   +K DF++I  H +     +KA   A+  AE+ E  +AE
Sbjct: 353 QGKPVDIKEFKKLDFTKIFDHYKALGDARKARPAAEKKAEKAEKDKAE 400

[30][TOP]
>UniRef100_C5DTC9 ZYRO0C07458p n=1 Tax=Zygosaccharomyces rouxii CBS 732
           RepID=C5DTC9_ZYGRC
          Length = 843

 Score =  112 bits (280), Expect = 2e-23
 Identities = 72/180 (40%), Positives = 97/180 (53%), Gaps = 8/180 (4%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           KVK E        K+ED        A + + A   EN    ++WWE   K D  VKWTTL
Sbjct: 176 KVKEEEEEKEDSTKSED--------AEADVDAEAEEN----YKWWEK-EKDDDTVKWTTL 222

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           +HNGV FPP YEP      + Y G  + LPP AEEVA F+A+ LQ+DH     F+SNFF 
Sbjct: 223 KHNGVIFPPTYEPLPSHIKMYYNGKPVDLPPQAEEVAGFFAALLQSDHAKNTVFQSNFFN 282

Query: 357 DFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK---AEKKAQTTAERKEARE 518
           DF  +L +   TK    I S +KCDF+++    E +K ++K    ++K Q   ER++  E
Sbjct: 283 DFIEVLNENGGTKNGINIESFDKCDFTKMFEFFEMQKEQRKQLSPQEKKQLRMEREKFEE 342

[31][TOP]
>UniRef100_B6JVY3 DNA topoisomerase I n=1 Tax=Schizosaccharomyces japonicus yFS275
           RepID=B6JVY3_SCHJY
          Length = 654

 Score =  112 bits (280), Expect = 2e-23
 Identities = 64/160 (40%), Positives = 90/160 (56%), Gaps = 4/160 (2%)
 Frame = +3

Query: 72  RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYE 245
           + +GS   + + E  +G F+WWE  +  DG+ KW TLEHNGV FPPEYEP      ++Y 
Sbjct: 209 KMSGSIRSSPKTEEENGDFKWWET-DLPDGK-KWNTLEHNGVMFPPEYEPLPSHVKMLYN 266

Query: 246 GMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKC 419
           G  + LPPAAEEVA F+ + L++DH     F+ NFF DF+A+   A  K A +      C
Sbjct: 267 GKPIDLPPAAEEVAGFFGALLESDHAQNPTFQKNFFRDFQAVCKEAGMKSADIPKEFNSC 326

Query: 420 DFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVR 539
           DF  +  + E  K  KK   K +   E K+ +E E E+ +
Sbjct: 327 DFRPMFEYFESLKEAKKNMSK-EEKKELKKKKEEEEEKFK 365

[32][TOP]
>UniRef100_Q6FNH4 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FNH4_CANGA
          Length = 744

 Score =  111 bits (277), Expect = 4e-23
 Identities = 60/139 (43%), Positives = 81/139 (58%), Gaps = 8/139 (5%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE   K D  +KW +L+HNGV FPPEYEP      L Y+G  + LPPAAEEVA F+A
Sbjct: 106 YKWWE-NEKNDDTIKWVSLKHNGVLFPPEYEPLPSHVKLYYDGKPVDLPPAAEEVAGFFA 164

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLE---DEKA 461
           + L TDH     F+ NFF DF  +L +   T+    IT  +KCDFS++  + E   +EK 
Sbjct: 165 NLLHTDHAKNPVFQKNFFEDFLQVLKESGGTRNKINITVFKKCDFSKMNQYFELKKEEKR 224

Query: 462 KKKAEKKAQTTAERKEARE 518
               E+K Q   E+ +  E
Sbjct: 225 NMSREEKKQIKLEKDKFEE 243

[33][TOP]
>UniRef100_A5DLX4 Putative uncharacterized protein n=1 Tax=Pichia guilliermondii
           RepID=A5DLX4_PICGU
          Length = 754

 Score =  111 bits (277), Expect = 4e-23
 Identities = 67/179 (37%), Positives = 97/179 (54%), Gaps = 3/179 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K+  +    K K E    S  + A       + +  +  ++WWEA +  DGE KW +L
Sbjct: 78  KTKSNGKNGQEKVKKETSQTSDAQLATPTDSIKKEKEEEETYKWWEAQDM-DGEQKWESL 136

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
            HNGV FPPEYEP      + Y+G  + L PAAEEVA F+A+ L+TDH     F+ NF+ 
Sbjct: 137 HHNGVMFPPEYEPLPSHVKMYYDGKPVDLAPAAEEVAGFFAAMLETDHAQNPVFQKNFWN 196

Query: 357 DFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
           DF  ++ ++  A V +    K DF+++ AH E  K +KK   + +  A  KEA+E E E
Sbjct: 197 DFLQVVKESGGANVEMKDFTKADFTKMHAHFEMLKEQKKNMSRDEKKA-LKEAKEKEEE 254

[34][TOP]
>UniRef100_A1CRV8 Topoisomerase I n=1 Tax=Aspergillus clavatus RepID=A1CRV8_ASPCL
          Length = 886

 Score =  111 bits (277), Expect = 4e-23
 Identities = 63/152 (41%), Positives = 84/152 (55%), Gaps = 10/152 (6%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275
           EGE  +  +RWW+   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P A
Sbjct: 233 EGEEEEEEYRWWDDPTKGDGTIKWTTLEHNGVVFPPPYEPLPQDVKMKYDGIPVTLHPEA 292

Query: 276 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431
           EEVA F+ S L  T HV    F+ NFF+DF+ +L  T  AK        I    KCDF  
Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFSDFKDILKKTGGAKDPKGNKIEIKEFSKCDFQS 352

Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           I A+ + ++ +K+    A+    + E   AEA
Sbjct: 353 IFAYYDAKRIEKRNIPPAEKKRLKAEKDAAEA 384

[35][TOP]
>UniRef100_UPI00017968A4 PREDICTED: similar to TOP1MT protein n=1 Tax=Equus caballus
           RepID=UPI00017968A4
          Length = 655

 Score =  110 bits (276), Expect = 5e-23
 Identities = 65/159 (40%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
 Frame = +3

Query: 72  RAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYE 245
           R A +P G  + E G   +RWWE     DG VKW  LEH G YF P YEP   G    Y+
Sbjct: 77  RDAEAPKGQEKEEAGQ--WRWWEEEKSQDG-VKWKQLEHKGPYFAPSYEPLPDGVHFYYD 133

Query: 246 GMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDF 425
           G  + L  AAEEVATFY   L  ++  KE F++NFF+D+R  +   +  K+I  L+KCDF
Sbjct: 134 GKPVKLSLAAEEVATFYGKMLDHEYTTKEVFQNNFFSDWRKEMT-AEERKIIKHLDKCDF 192

Query: 426 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
           + I  +  D+ A +KA      + E K+  + EAE+++Q
Sbjct: 193 TEIHRYFVDKTAARKA-----LSREEKQKLKEEAEKLQQ 226

[36][TOP]
>UniRef100_Q1DXZ1 Putative uncharacterized protein n=1 Tax=Coccidioides immitis
           RepID=Q1DXZ1_COCIM
          Length = 905

 Score =  110 bits (276), Expect = 5e-23
 Identities = 66/145 (45%), Positives = 82/145 (56%), Gaps = 11/145 (7%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ 
Sbjct: 260 YRWWEEPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFG 319

Query: 300 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 455
           S L + H V    F+ NFF DF A++  T  AK       +I   +KCDF  I  + E  
Sbjct: 320 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE-- 377

Query: 456 KAKKKAEKKAQTTAERKEAR-EAEA 527
              K+ EKKA   AERK  + E EA
Sbjct: 378 --MKREEKKALPAAERKRLKAEKEA 400

[37][TOP]
>UniRef100_C5P0Y8 DNA topoisomerase I, putative n=1 Tax=Coccidioides posadasii C735
           delta SOWgp RepID=C5P0Y8_COCP7
          Length = 905

 Score =  110 bits (276), Expect = 5e-23
 Identities = 66/145 (45%), Positives = 82/145 (56%), Gaps = 11/145 (7%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ 
Sbjct: 260 YRWWEEPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPISLEPDAEEVAGFFG 319

Query: 300 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 455
           S L + H V    F+ NFF DF A++  T  AK       +I   +KCDF  I  + E  
Sbjct: 320 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKDSQGNKVLIKDFKKCDFRPIFEYYE-- 377

Query: 456 KAKKKAEKKAQTTAERKEAR-EAEA 527
              K+ EKKA   AERK  + E EA
Sbjct: 378 --MKREEKKALPAAERKRLKVEKEA 400

[38][TOP]
>UniRef100_A2Q8K2 Catalytic activity: ATP-independent breakage of single-stranded DNA
           n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2Q8K2_ASPNC
          Length = 884

 Score =  110 bits (276), Expect = 5e-23
 Identities = 69/166 (41%), Positives = 91/166 (54%), Gaps = 17/166 (10%)
 Frame = +3

Query: 75  AAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPL 236
           A  +P+   E E  +      +RWWE   K DG +KWTTLEHNGV FPP YE  P    +
Sbjct: 218 AKSTPVKKEESEEAEDADEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKM 277

Query: 237 IYEGMELHLPPAAEEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK------ 395
            Y+G+ + L P AEEVA F+   L  T HV    F+ NFF DFR +L  T  AK      
Sbjct: 278 KYDGIPVTLHPDAEEVAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNK 337

Query: 396 -VITSLEKCDFSRIEAHLEDEKAKKKA---EKKAQTTAERKEAREA 521
             I    KCDF  I A+ ++++ +KKA    +K +  AE K+A+EA
Sbjct: 338 VDIKDFHKCDFQPIFAYYDNQRQEKKALPPAEKKRLKAE-KDAQEA 382

[39][TOP]
>UniRef100_Q75CB7 ACL008Cp n=1 Tax=Eremothecium gossypii RepID=Q75CB7_ASHGO
          Length = 732

 Score =  110 bits (275), Expect = 7e-23
 Identities = 63/179 (35%), Positives = 90/179 (50%), Gaps = 5/179 (2%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K  ++RR    K K E+     G        + +GE     F+WWE   + D  VKW TL
Sbjct: 57  KTVSKRRAPARKVKEEE-----GDRDAKKESSVDGEEDSEEFKWWEREEEKDDSVKWVTL 111

Query: 183 EHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
            HNGV FPPEY   P    L Y G  + LP  AEEVA F+A+ LQ+DH     F+ NFF 
Sbjct: 112 RHNGVMFPPEYTPLPSHVRLYYGGKAVELPAEAEEVAGFFAALLQSDHAQNPVFQKNFFE 171

Query: 357 DFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
           DF ++L     A+    I    KCDFS++ A+++ ++ + K     +    ++E  + E
Sbjct: 172 DFLSVLNKHGGARNGIDIQEFSKCDFSKMHAYIQQQRVQMKQLSSHERKLLKQEKGQTE 230

[40][TOP]
>UniRef100_B0XN02 Topoisomerase I n=2 Tax=Aspergillus fumigatus RepID=B0XN02_ASPFC
          Length = 998

 Score =  110 bits (275), Expect = 7e-23
 Identities = 65/154 (42%), Positives = 83/154 (53%), Gaps = 10/154 (6%)
 Frame = +3

Query: 96  AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 269
           A EGE  +  +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P
Sbjct: 343 AEEGEEEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHP 402

Query: 270 AAEEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDF 425
            AEEVA F+ S L  T HV    F+ NFF DF+ +L  T  AK        I    KCDF
Sbjct: 403 EAEEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLEKTGGAKDPKGNKIEIKEFSKCDF 462

Query: 426 SRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
             I  + + ++ +KK    A+    + E   AEA
Sbjct: 463 RPIFDYYDAKRIEKKNLPPAEKKRLKAEKDAAEA 496

[41][TOP]
>UniRef100_A4R0K7 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea
           RepID=A4R0K7_MAGGR
          Length = 906

 Score =  110 bits (275), Expect = 7e-23
 Identities = 72/184 (39%), Positives = 90/184 (48%), Gaps = 10/184 (5%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188
           K+  + A  K K      +  + A   +   E E  +  +RWW+A  K D  +KW TLEH
Sbjct: 219 KSAAKAAPAKGKAAAAKKTNAKQASEEVEGDEEEEEE--YRWWDAPKKEDDSIKWNTLEH 276

Query: 189 NGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSNFFAD 359
           NGV FPP+YE  P    L Y G+ L L P AEEVATF+ S L  T +V    F  NFF  
Sbjct: 277 NGVLFPPDYEPLPKNVKLYYNGIPLQLHPEAEEVATFFGSMLHSTQNVENPTFIKNFFTG 336

Query: 360 FRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
           F+  L  T  AK        I   EK DF  I  H + +   KKA  K +  AE KEAR+
Sbjct: 337 FKDKLKKTGGAKDKNGNKVDIKEFEKLDFKPIFQHFQAQSEAKKARSKEEKKAE-KEARD 395

Query: 519 AEAE 530
              E
Sbjct: 396 KMEE 399

[42][TOP]
>UniRef100_A1D4R5 Topoisomerase I n=1 Tax=Neosartorya fischeri NRRL 181
           RepID=A1D4R5_NEOFI
          Length = 886

 Score =  110 bits (275), Expect = 7e-23
 Identities = 65/152 (42%), Positives = 82/152 (53%), Gaps = 10/152 (6%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275
           EGE  +  +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P A
Sbjct: 233 EGEEEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPSDVKMKYDGVPVTLHPEA 292

Query: 276 EEVATFYASKLQ-TDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431
           EEVA F+ S L  T HV    F+ NFF DF+ +L  T  AK        I    KCDF  
Sbjct: 293 EEVAGFFGSMLNATQHVENPTFQKNFFMDFKEVLKKTGGAKDPKGNKIEIKEFSKCDFRP 352

Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           I  + E ++ +KK    A+    + E   AEA
Sbjct: 353 IFDYYEAKRIEKKNLPPAEKKRLKAEKDAAEA 384

[43][TOP]
>UniRef100_C1GKM6 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb18
           RepID=C1GKM6_PARBD
          Length = 825

 Score =  110 bits (274), Expect = 9e-23
 Identities = 64/152 (42%), Positives = 81/152 (53%), Gaps = 10/152 (6%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275
           E E G+  +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P A
Sbjct: 252 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 311

Query: 276 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431
           EEVA F+ S L + H V    F+ NFF DF A +  +  AK        I S +KCDF  
Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371

Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           I    E  + +KKA    +    + E  E EA
Sbjct: 372 IFEFYEAARLEKKALPATEKKRLKAEKDELEA 403

[44][TOP]
>UniRef100_C0SEQ3 DNA topoisomerase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0SEQ3_PARBP
          Length = 905

 Score =  110 bits (274), Expect = 9e-23
 Identities = 64/152 (42%), Positives = 81/152 (53%), Gaps = 10/152 (6%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAA 275
           E E G+  +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P A
Sbjct: 252 EAEEGEEEYRWWEDPTKGDGTIKWTTLEHNGVIFPPPYEPLPKHVKMKYDGVPITLAPEA 311

Query: 276 EEVATFYASKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSR 431
           EEVA F+ S L + H V    F+ NFF DF A +  +  AK        I S +KCDF  
Sbjct: 312 EEVAGFFGSMLNSTHNVENPTFQKNFFNDFTAYVKKSGGAKDPNGNPVAINSFDKCDFKP 371

Query: 432 IEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           I    E  + +KKA    +    + E  E EA
Sbjct: 372 IFEFYEAARLEKKALPATEKKRLKAEKDELEA 403

[45][TOP]
>UniRef100_UPI000151AE34 hypothetical protein PGUG_04275 n=1 Tax=Pichia guilliermondii ATCC
           6260 RepID=UPI000151AE34
          Length = 754

 Score =  109 bits (273), Expect = 1e-22
 Identities = 71/180 (39%), Positives = 99/180 (55%), Gaps = 4/180 (2%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTE-DRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179
           K K   +    K K E  +TL    A  + L   E E  +  ++WWEA +  DGE KW +
Sbjct: 78  KTKLNGKNGQEKVKKETSQTLDAQLATPTDLIKKEKEEEET-YKWWEAQDM-DGEQKWES 135

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           L HNGV FPPEYEP      + Y+G  + L PAAEEVA F+A+ L+TDH     F+ NF+
Sbjct: 136 LHHNGVMFPPEYEPLPSHVKMYYDGKPVDLAPAAEEVAGFFAAMLETDHAQNPVFQKNFW 195

Query: 354 ADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
            DF  ++ ++  A V +    K DF+++ AH E  K +KK   + +  A  KEA+E E E
Sbjct: 196 NDFLQVVKESGGANVEMKDFTKADFTKMHAHFEMLKEQKKNMSRDEKKA-LKEAKEKEEE 254

[46][TOP]
>UniRef100_B2AY06 Predicted CDS Pa_1_9460 n=1 Tax=Podospora anserina
           RepID=B2AY06_PODAN
          Length = 904

 Score =  109 bits (273), Expect = 1e-22
 Identities = 74/187 (39%), Positives = 95/187 (50%), Gaps = 12/187 (6%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAG--SPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176
           KVK E   A  K K        GR     S   +A  E  +  +RWW+A  K D  +KWT
Sbjct: 213 KVKKEAP-AKAKVKAAAAPAKKGRLVKEESVANSAADEEEEEEYRWWDAPKKEDDSIKWT 271

Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFRSN 347
           TLEHNGV FPP YE  P    LIY+G  ++L   AEEVATF+ + L  T +V    F+ N
Sbjct: 272 TLEHNGVLFPPAYEPLPKDVKLIYDGTPVNLHVDAEEVATFFGAMLHSTQNVENPTFQKN 331

Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           FF DFR +L +T  AK        I    K DF++I  + +     KKA   A+  AE+ 
Sbjct: 332 FFKDFRDVLKETGGAKDQNGKPVDIKEFAKLDFTKIFEYYKGLSEAKKARPAAEKKAEKA 391

Query: 507 EAREAEA 527
           E  + EA
Sbjct: 392 EKDKFEA 398

[47][TOP]
>UniRef100_UPI00003BE191 hypothetical protein DEHA0F10945g n=1 Tax=Debaryomyces hansenii
           CBS767 RepID=UPI00003BE191
          Length = 789

 Score =  109 bits (272), Expect = 1e-22
 Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 3/183 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K  +     K     +     +    P    E E  +  ++WWEA +  DGE KW +L
Sbjct: 113 KSKGAKSTGSNKTDAVKKEDEVAKTEKDPSSTREDEEDEEKYKWWEAED-VDGEQKWESL 171

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EHNGV FPP+YEP      L Y+G  + LP  AEEVA F+ +  +TDH     F+ NFF 
Sbjct: 172 EHNGVIFPPDYEPLPSHVKLYYDGKPVDLPLEAEEVAGFFGAMAETDHAKNPTFQKNFFE 231

Query: 357 DFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533
           DF  +L D     V I    + DFS++ AH E  + +KK   K     + K+A +AE ++
Sbjct: 232 DFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAEKDK 286

Query: 534 VRQ 542
             +
Sbjct: 287 FEE 289

[48][TOP]
>UniRef100_Q6BLX2 DEHA2F09988p n=1 Tax=Debaryomyces hansenii RepID=Q6BLX2_DEBHA
          Length = 789

 Score =  109 bits (272), Expect = 1e-22
 Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 3/183 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K  +     K     +     +    P    E E  +  ++WWEA +  DGE KW +L
Sbjct: 113 KSKGAKSTGSNKTDAVKKEDEVAKTEKDPSSTREDEEDEEKYKWWEAED-VDGEQKWESL 171

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EHNGV FPP+YEP      L Y+G  + LP  AEEVA F+ +  +TDH     F+ NFF 
Sbjct: 172 EHNGVIFPPDYEPLPSHVKLYYDGKPVDLPLEAEEVAGFFGAMAETDHAKNPTFQKNFFE 231

Query: 357 DFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533
           DF  +L D     V I    + DFS++ AH E  + +KK   K     + K+A +AE ++
Sbjct: 232 DFCKVLKDAGGCNVNIIDFHRMDFSKMHAHFEMLRDQKKLLSK-----DEKKAIKAEKDK 286

Query: 534 VRQ 542
             +
Sbjct: 287 FEE 289

[49][TOP]
>UniRef100_C5GB81 DNA topoisomerase I n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GB81_AJEDR
          Length = 911

 Score =  109 bits (272), Expect = 1e-22
 Identities = 69/187 (36%), Positives = 94/187 (50%), Gaps = 12/187 (6%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAE--GENGDGGFRWWEAGNKTDGEVKWT 176
           KV A++ V   K++  D      + A     + E  GE  +  +RWWE   + DG +KWT
Sbjct: 223 KVPAKKSVKAFKSEPADTKKGKAKVAMKKESSEELEGEEAEEEYRWWEDPAQGDGTIKWT 282

Query: 177 TLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSN 347
           TLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L + H V    F+ N
Sbjct: 283 TLEHNGVIFPPPYEPLPKHVKMKYDGIPITLAPEAEEVAGFFGSMLNSTHNVENPTFQKN 342

Query: 348 FFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           FF DF A +  +  AK        I S + CDF  I  + E  + +KK    A+    + 
Sbjct: 343 FFTDFTAYIKKSGGAKDPNGNPVAIKSFDSCDFKPIFEYYEAARLEKKNLPAAEKKRLKA 402

Query: 507 EAREAEA 527
           E  E EA
Sbjct: 403 EKDELEA 409

[50][TOP]
>UniRef100_B9SSQ1 DNA topoisomerase type I, putative n=1 Tax=Ricinus communis
           RepID=B9SSQ1_RICCO
          Length = 891

 Score =  108 bits (271), Expect = 2e-22
 Identities = 60/129 (46%), Positives = 77/129 (59%)
 Frame = +3

Query: 147 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326
           + TDG+ KWTTL HNGV FPP Y+PHG  ++Y+G  + L P  EEVAT +A    TD++ 
Sbjct: 340 SSTDGQKKWTTLIHNGVIFPPPYKPHGIKILYKGRPVDLAPEQEEVATMFAVMKDTDYMQ 399

Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           K KF  NF+ D+R LL       VI  LE CDF+ I    E EK     EKK Q + E K
Sbjct: 400 KPKFLENFWNDWRKLLGRN---HVIQKLEDCDFTPIYEWHEREK-----EKKKQMSTEEK 451

Query: 507 EAREAEAER 533
           +A++ E  R
Sbjct: 452 KAQKEEKLR 460

[51][TOP]
>UniRef100_C5DEP3 KLTH0C10890p n=1 Tax=Lachancea thermotolerans CBS 6340
           RepID=C5DEP3_LACTC
          Length = 756

 Score =  108 bits (270), Expect = 3e-22
 Identities = 68/186 (36%), Positives = 98/186 (52%), Gaps = 6/186 (3%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDG-GFRWWEAGNKTDGEVKWTT 179
           K  A +RVA    K   R  S  +    P   ++    D   F+WWE  N+ D  +KWTT
Sbjct: 76  KKSATKRVAKKAKKAVKREPSVEQQNAEPEEDSKELTEDADSFKWWEKENEDDS-IKWTT 134

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           L+HNGV FPP YEP      L Y+G  + LPP AEEVA F+A+ L++DH     F+ NFF
Sbjct: 135 LKHNGVIFPPPYEPLPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAQNPVFQKNFF 194

Query: 354 ADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
            DF  +L +    K    I   E CDFS++  + + +K     E+K Q +++ K+  + E
Sbjct: 195 NDFLDVLRENGGPKNGAEIEKFELCDFSKMFDYFQLQK-----EQKKQLSSQEKKKLKIE 249

Query: 525 AERVRQ 542
            E+  +
Sbjct: 250 KEQFEE 255

[52][TOP]
>UniRef100_C4XZS7 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC
           42720 RepID=C4XZS7_CLAL4
          Length = 764

 Score =  108 bits (270), Expect = 3e-22
 Identities = 62/144 (43%), Positives = 82/144 (56%), Gaps = 6/144 (4%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G  +W TLEHNGV FPP Y+P      L Y+   ++LP AAEEVA F+A
Sbjct: 128 YKWWEDEKFGEGPDRWQTLEHNGVIFPPPYKPLPSYVKLYYDSKPVNLPLAAEEVAGFFA 187

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 476
             L+TDH     F+ NFF DF  +L +     V IT  +KCDFS++ AH      K + E
Sbjct: 188 EMLETDHAKNPVFQKNFFEDFLQVLRENGGCDVDITEFDKCDFSKMHAHF----VKVREE 243

Query: 477 KKAQTTAER---KEAREAEAERVR 539
           KK  + AE+   K+ REA  E  R
Sbjct: 244 KKNMSKAEKLRLKQEREALEEPYR 267

[53][TOP]
>UniRef100_C4PFJ5 Topoisomerase I n=1 Tax=Fusarium culmorum RepID=C4PFJ5_FUSCU
          Length = 909

 Score =  108 bits (270), Expect = 3e-22
 Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 24/192 (12%)
 Frame = +3

Query: 18  RRVAGGKAKTEDRTLSPGRAAGSPLGAAEG---------ENGDGGFRWWEAGNKTDGEVK 170
           +R + G  K E  + +P      P  A +G         E+ +  F WW A  K D  +K
Sbjct: 209 KRKSNGVKKEESDSDAPISKKARPAAAKKGAKAESKKASESDEEEFEWWNAPKKEDDSIK 268

Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL---QTDHVLKEK 335
           WTTLEHNGV FPP+YE  P    ++Y+G  + L P  EEVATF+ + +      H+    
Sbjct: 269 WTTLEHNGVLFPPDYEPLPKNVKMLYDGQPVTLAPEVEEVATFWVAMMTAASIHHLENPV 328

Query: 336 FRSNFFADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKA 485
           FR NFF DF+       + D +  KV I SL+KC+F +I  +    +E  K K   +++ 
Sbjct: 329 FRKNFFDDFKVYCDKYGVTDAQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEK 388

Query: 486 QTTAERKEAREA 521
           +    +K+A EA
Sbjct: 389 EAAKAKKDALEA 400

[54][TOP]
>UniRef100_UPI000023DEFB hypothetical protein FG06874.1 n=1 Tax=Gibberella zeae PH-1
           RepID=UPI000023DEFB
          Length = 910

 Score =  108 bits (269), Expect = 3e-22
 Identities = 64/187 (34%), Positives = 95/187 (50%), Gaps = 15/187 (8%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLE 185
           VK E   +      + R  +  + A +    A   +G+  F WW A  K D  +KWTTLE
Sbjct: 215 VKKEESDSDAPISKKVRPAAAKKGAKAESKKASESDGEEEFEWWNAPKKEDDSIKWTTLE 274

Query: 186 HNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL---QTDHVLKEKFRSNF 350
           HNGV FPP+YE  P    ++Y+G  + L P  EEVATF+ + +      H+    FR NF
Sbjct: 275 HNGVLFPPDYEPLPKNVKMLYDGQPVTLAPEVEEVATFWVAMMTAASIHHLENPVFRKNF 334

Query: 351 FADFRAL-----LADTKFAKV-ITSLEKCDFSRIEAH----LEDEKAKKKAEKKAQTTAE 500
           F DF+       + D +  KV I SL+KC+F +I  +    +E  K K   +++ +    
Sbjct: 335 FDDFKVYCDKYGVTDVQGKKVAIKSLDKCNFDKINDYWTKRVEQNKTKNMTKEEKEAAKA 394

Query: 501 RKEAREA 521
           +K+A EA
Sbjct: 395 KKDALEA 401

[55][TOP]
>UniRef100_A9T3W2 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9T3W2_PHYPA
          Length = 632

 Score =  108 bits (269), Expect = 3e-22
 Identities = 55/118 (46%), Positives = 74/118 (62%)
 Frame = +3

Query: 165 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344
           VKWTTLEHNGV FPP YEPHG  ++Y+G  + L PA EE+AT +A  L+TD+  KE+F  
Sbjct: 89  VKWTTLEHNGVIFPPPYEPHGVKMLYDGKPVDLTPAQEEIATMFAVMLETDYAKKERFIK 148

Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
           NF+ D++  L       VI   E CDF+ I     D  A++K  KK+ +T E+K  +E
Sbjct: 149 NFWDDWKPYLGKN---HVIKKFELCDFTPI----FDWHAREKERKKSMSTEEKKRLKE 199

[56][TOP]
>UniRef100_Q9Y180 Topoisomerase I-like protein n=1 Tax=Leishmania infantum
           RepID=Q9Y180_LEIIN
          Length = 635

 Score =  107 bits (268), Expect = 4e-22
 Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           E  +    WWE  N      GE +W TL HNGV FPPEYEPHG P+ Y+G E  + P  E
Sbjct: 22  EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 446
           EVAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I + HL   
Sbjct: 82  EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 139

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 539
           E + ++ K EKKA      KE ++AEAE  R
Sbjct: 140 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 165

[57][TOP]
>UniRef100_Q9NJG8 DNA topoisomerase I n=1 Tax=Leishmania donovani donovani
           RepID=Q9NJG8_LEIDO
          Length = 949

 Score =  107 bits (268), Expect = 4e-22
 Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           E  +    WWE  N      GE +W TL HNGV FPPEYEPHG P+ Y+G E  + P  E
Sbjct: 337 EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 396

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 446
           EVAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I + HL   
Sbjct: 397 EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 454

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 539
           E + ++ K EKKA      KE ++AEAE  R
Sbjct: 455 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 480

[58][TOP]
>UniRef100_Q9GPZ9 DNA topoisomerase I n=1 Tax=Leishmania infantum RepID=Q9GPZ9_LEIIN
          Length = 635

 Score =  107 bits (268), Expect = 4e-22
 Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           E  +    WWE  N      GE +W TL HNGV FPPEYEPHG P+ Y+G E  + P  E
Sbjct: 22  EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHL--- 446
           EVAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I + HL   
Sbjct: 82  EVATMFAVMKEHDYYRMEVFRRNFFESWREIL--DKRQHPIRRLELCDFEPIYQWHLVQR 139

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVR 539
           E + ++ K EKKA      KE ++AEAE  R
Sbjct: 140 EKKLSRTKEEKKA-----IKEKQDAEAEPYR 165

[59][TOP]
>UniRef100_Q4DTW1 DNA topoisomerase IB, large subunit, putative n=1 Tax=Trypanosoma
           cruzi RepID=Q4DTW1_TRYCR
          Length = 664

 Score =  107 bits (268), Expect = 4e-22
 Identities = 62/138 (44%), Positives = 77/138 (55%), Gaps = 4/138 (2%)
 Frame = +3

Query: 132 WWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS 302
           WWE  N    T G+ +W TL HNGV FPPEY+PHG P+ YEG E  L P  EEVAT +A 
Sbjct: 33  WWEQENVQFTTKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAV 92

Query: 303 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEK 479
             + D+   E FR NFF+ +R +L   K    I  LE CDF  I + HL      ++ EK
Sbjct: 93  MREHDYYRNEIFRRNFFSSWREIL--DKRQHPIRRLELCDFEPIYQWHL------REREK 144

Query: 480 KAQTTAERKEAREAEAER 533
           K   T E K+    EAE+
Sbjct: 145 KLSRTKEEKKQLRLEAEK 162

[60][TOP]
>UniRef100_A4HB62 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania braziliensis
           RepID=A4HB62_LEIBR
          Length = 637

 Score =  107 bits (268), Expect = 4e-22
 Identities = 63/168 (37%), Positives = 86/168 (51%), Gaps = 4/168 (2%)
 Frame = +3

Query: 42  KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPE 212
           K EDR ++  R         + EN +    WWE  N      GE +W TL HNGV FPPE
Sbjct: 2   KVEDRKMAVKREQSH--SNEDEENNEEDLNWWEQENLRIAMKGERRWETLSHNGVLFPPE 59

Query: 213 YEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFA 392
           YEPHG  + Y+G E  + P  EEVAT +A   + D+   E FR NFF  +R +L   K  
Sbjct: 60  YEPHGISIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEAFRRNFFESWREIL--DKRQ 117

Query: 393 KVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533
             I  LE CDF  I + +L + + K    K+ + + + K+  +AE  R
Sbjct: 118 HPIRRLELCDFEPIYQWYLAEREKKLNRTKEEKKSIKEKQDMDAEPYR 165

[61][TOP]
>UniRef100_Q875K2 Topoisomerase I n=1 Tax=Emericella nidulans RepID=Q875K2_EMENI
          Length = 871

 Score =  107 bits (268), Expect = 4e-22
 Identities = 67/146 (45%), Positives = 84/146 (57%), Gaps = 14/146 (9%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ 
Sbjct: 226 YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285

Query: 300 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI----EAH 443
           S L  T H     F+ NFFADF+ +L  T  AK        I    KCDF  I    +A 
Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQ 345

Query: 444 LEDEKAKKKAEKKAQTTAERKEAREA 521
            +++KA   AEKK +  AE K+A+EA
Sbjct: 346 RQEKKALPPAEKK-RLKAE-KDAQEA 369

[62][TOP]
>UniRef100_Q0CUT4 DNA topoisomerase I n=1 Tax=Aspergillus terreus NIH2624
           RepID=Q0CUT4_ASPTN
          Length = 872

 Score =  107 bits (268), Expect = 4e-22
 Identities = 70/189 (37%), Positives = 97/189 (51%), Gaps = 14/189 (7%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGG----FRWWEAGNKTDGEVK 170
           KVK+E + A      +   +  G A  +P+   E  + +      +RWWE   K+DG +K
Sbjct: 188 KVKSEPKSA------QSTPVKKGSAKATPVKKEESADAEEAEEEEYRWWEDPTKSDGTIK 241

Query: 171 WTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL-QTDHVLKEKFR 341
           WTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ S L  T H     F+
Sbjct: 242 WTTLEHNGVVFPPPYEPLPKNVKMKYDGVPVTLHPDAEEVAGFFGSMLNSTQHTENPTFQ 301

Query: 342 SNFFADFRALL------ADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAE 500
            NFF DF+ +L       D K  KV I   +KCDF  I  + E ++ +K+    A+    
Sbjct: 302 KNFFMDFKDILKKTGGATDPKGNKVDIKEFKKCDFQPIFDYYEAKRIEKRNLPAAEKKRL 361

Query: 501 RKEAREAEA 527
           + E  E EA
Sbjct: 362 KAEKDEQEA 370

[63][TOP]
>UniRef100_C8VUK1 Topoisomerase I [Source:UniProtKB/TrEMBL;Acc:Q875K2] n=2
           Tax=Emericella nidulans RepID=C8VUK1_EMENI
          Length = 871

 Score =  107 bits (268), Expect = 4e-22
 Identities = 67/146 (45%), Positives = 84/146 (57%), Gaps = 14/146 (9%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ 
Sbjct: 226 YRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285

Query: 300 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRI----EAH 443
           S L  T H     F+ NFFADF+ +L  T  AK        I    KCDF  I    +A 
Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDFQPIFQYYDAQ 345

Query: 444 LEDEKAKKKAEKKAQTTAERKEAREA 521
            +++KA   AEKK +  AE K+A+EA
Sbjct: 346 RQEKKALPPAEKK-RLKAE-KDAQEA 369

[64][TOP]
>UniRef100_B9GJH5 Predicted protein n=1 Tax=Populus trichocarpa RepID=B9GJH5_POPTR
          Length = 877

 Score =  107 bits (267), Expect = 6e-22
 Identities = 56/131 (42%), Positives = 79/131 (60%)
 Frame = +3

Query: 153 TDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332
           +DG+ KWTTL HNGV FPP Y+PHG  ++Y+G  + L P  EEVAT +A    TD+V K 
Sbjct: 329 SDGQKKWTTLVHNGVIFPPPYKPHGVKILYKGKPIDLTPEQEEVATMFAVMKDTDYVQKP 388

Query: 333 KFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512
           +FR NF+ D+R LL       VI  L+ CDF+ I    + EK K    KK  +T E+K  
Sbjct: 389 QFRQNFWNDWRKLLGKN---HVIQKLDDCDFNPIYEWHQQEKEK----KKQMSTEEKKVL 441

Query: 513 REAEAERVRQF 545
           +E + ++  ++
Sbjct: 442 KEEKLKQEEKY 452

[65][TOP]
>UniRef100_Q4Q2K0 DNA topoisomerase IB, large subunit n=1 Tax=Leishmania major
           RepID=Q4Q2K0_LEIMA
          Length = 634

 Score =  107 bits (267), Expect = 6e-22
 Identities = 62/147 (42%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           E  +    WWE  N      GE +W TL HNGV FPPEYEPHG P+ Y+G E  + P  E
Sbjct: 22  EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 458
           EVAT +A   + D+   E FR NFF  +R +L   K    I  LE CDF  I      ++
Sbjct: 82  EVATMFAVMKEHDYYRMEVFRRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQR 139

Query: 459 AKKKAEKKAQTTAERKEAREAEAERVR 539
            KK +  K +  A  KE ++AEAE  R
Sbjct: 140 EKKLSRTKEEKKA-IKEKQDAEAEPYR 165

[66][TOP]
>UniRef100_Q6Y634 Type I topoisomerase n=1 Tax=Trypanosoma cruzi RepID=Q6Y634_TRYCR
          Length = 664

 Score =  107 bits (266), Expect = 7e-22
 Identities = 61/138 (44%), Positives = 77/138 (55%), Gaps = 4/138 (2%)
 Frame = +3

Query: 132 WWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS 302
           WWE  N    T G+ +W TL HNGV FPPEY+PHG P+ YEG E  L P  EEVAT +A 
Sbjct: 33  WWELENVQFSTKGQKRWDTLCHNGVMFPPEYKPHGIPIYYEGREFKLTPEEEEVATMFAV 92

Query: 303 KLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEK 479
             + D+   E FR NFF+ +R +L   +    I  LE CDF  I + HL      ++ EK
Sbjct: 93  MREHDYYRNEIFRRNFFSSWREIL--DRRQHPIRRLELCDFEPIYQWHL------REREK 144

Query: 480 KAQTTAERKEAREAEAER 533
           K   T E K+    EAE+
Sbjct: 145 KLSRTKEEKKQLRLEAEK 162

[67][TOP]
>UniRef100_A7TJW1 Putative uncharacterized protein n=1 Tax=Vanderwaltozyma polyspora
           DSM 70294 RepID=A7TJW1_VANPO
          Length = 799

 Score =  107 bits (266), Expect = 7e-22
 Identities = 56/139 (40%), Positives = 79/139 (56%), Gaps = 8/139 (5%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  N  +GE++WTTL HNGV FPP Y   P    L Y G  + LPP AEEVA F+A
Sbjct: 161 YKWWE-DNDDNGEIQWTTLRHNGVMFPPPYVSLPSHIKLYYNGQAVDLPPTAEEVAGFFA 219

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLE---DEKA 461
           + L TDH     F+ NFF DF+ +L +   T     +   E CDFS++  + E   +++ 
Sbjct: 220 ALLHTDHAKNTVFQKNFFTDFKEVLKEVGGTLNGIKLEKFEYCDFSKMHEYFEIQREQRK 279

Query: 462 KKKAEKKAQTTAERKEARE 518
           K   ++K Q   E++E  E
Sbjct: 280 KLSPQEKKQLRLEKEEQEE 298

[68][TOP]
>UniRef100_B2DDA8 Topoisomerase I n=1 Tax=Catharanthus roseus RepID=B2DDA8_CATRO
          Length = 910

 Score =  106 bits (265), Expect = 1e-21
 Identities = 54/126 (42%), Positives = 76/126 (60%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KW  LEHNGV FPP Y+PHG  ++Y+G  + L P  EEVAT +A  L TD++ K +F+ N
Sbjct: 365 KWNKLEHNGVIFPPPYKPHGIKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMNKPRFKEN 424

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           FF D++ +L       VI +LE CDFS I    + EK K    KK  TT E+K  +E + 
Sbjct: 425 FFGDWKKILGKN---HVIQNLENCDFSPIYEWHQSEKEK----KKQMTTEEKKALKEEKL 477

Query: 528 ERVRQF 545
           ++  ++
Sbjct: 478 KQEEKY 483

[69][TOP]
>UniRef100_A7QDA6 Chromosome undetermined scaffold_80, whole genome shotgun sequence
           n=1 Tax=Vitis vinifera RepID=A7QDA6_VITVI
          Length = 857

 Score =  106 bits (265), Expect = 1e-21
 Identities = 55/117 (47%), Positives = 73/117 (62%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV FPP Y+PHG  ++Y+G  + L P  EEVAT +A  L TD++ KEKF+ N
Sbjct: 315 KWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMQKEKFKEN 374

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
           F AD+R +L       VI  L+ CDF+ I    ++EK K    KK  +T E+K  +E
Sbjct: 375 FMADWRKILGKN---HVIQRLDDCDFTPIYEWHQEEKEK----KKQMSTEEKKTLKE 424

[70][TOP]
>UniRef100_B6H1W4 Pc13g03270 protein n=1 Tax=Penicillium chrysogenum Wisconsin
           54-1255 RepID=B6H1W4_PENCW
          Length = 864

 Score =  106 bits (265), Expect = 1e-21
 Identities = 68/185 (36%), Positives = 95/185 (51%), Gaps = 26/185 (14%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRTLSPGRAAGSPL------------GAAEGENGDGGFRWWEAGNK 152
           K E + A  K +T      P  +  +P                + E  +  +RWWE  +K
Sbjct: 167 KKEAKPAAAKKQTNGVKKEPAASKAAPKKGKAKVKEESQDAEEKDEEEEEEYRWWEDQSK 226

Query: 153 TDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-V 323
            DG +KWTTLEHNGV FPPEYE  P    + Y+G+ + L P AEEVA+F+ + L + H V
Sbjct: 227 GDGTIKWTTLEHNGVVFPPEYELLPQNVKMKYDGIPITLAPEAEEVASFFGTMLNSTHNV 286

Query: 324 LKEKFRSNFFADFRALL------ADTKFAKV-ITSLEKCDFSRI----EAHLEDEKAKKK 470
               F+ NFF+DF+ ++       D+K  KV I    KCDF  I    +A  E+++    
Sbjct: 287 ENPVFQKNFFSDFKDVIKKSGGAKDSKGNKVDIKEFAKCDFKPIFEFYDAQREEKRHLPP 346

Query: 471 AEKKA 485
           AEKKA
Sbjct: 347 AEKKA 351

[71][TOP]
>UniRef100_B7Q9Y0 DNA topoisomerase I, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q9Y0_IXOSC
          Length = 499

 Score =  106 bits (264), Expect = 1e-21
 Identities = 67/180 (37%), Positives = 96/180 (53%), Gaps = 3/180 (1%)
 Frame = +3

Query: 6   VKAERRVAGGKAK-TEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           +K  ++    KAK TE +T S   A+    G A+ E     ++WWE     DG+ KW TL
Sbjct: 176 IKPAKKSMPKKAKLTEVKTESEPTASKKKKGRAKKEEEVEVWKWWEEEKHDDGK-KWRTL 234

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP        Y+   + L PAAEEVA FY   L  D+  KE F  NFF 
Sbjct: 235 EHKGPVFAPPYEPLPDNVRFFYDNKVVKLSPAAEEVAGFYGRMLDHDYTSKEAFNKNFFK 294

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536
           D+R  +   K A++IT L KC+F  I+ +      K+K+E++   + E K+A +A+ E++
Sbjct: 295 DWRKTMT-PKEAELITDLSKCNFKEIDVYY-----KQKSEERKAMSKEEKQAIKAQNEKL 348

[72][TOP]
>UniRef100_UPI0001760D92 PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Danio
           rerio RepID=UPI0001760D92
          Length = 748

 Score =  105 bits (263), Expect = 2e-21
 Identities = 59/141 (41%), Positives = 81/141 (57%), Gaps = 2/141 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE    TDG  KW  LEH G  FPP YEP        Y+G  + L PAAEEVATFYA
Sbjct: 186 WKWWEEERYTDGS-KWRFLEHKGPVFPPPYEPLPGHIKFYYDGNAMKLSPAAEEVATFYA 244

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L+ ++   E FR NFF D+R  +   + +K IT L+KCDF+++      E  K ++E 
Sbjct: 245 KMLEHEYTTNEIFRKNFFKDWRKEMTSEEKSK-ITELKKCDFTQMH-----EYFKAQSEA 298

Query: 480 KAQTTAERKEAREAEAERVRQ 542
           + Q + E K+  + E ER+ Q
Sbjct: 299 RKQMSKEEKQKNKEENERILQ 319

[73][TOP]
>UniRef100_Q581U8 DNA topoisomerase IB, large subunit n=1 Tax=Trypanosoma brucei
           RepID=Q581U8_9TRYP
          Length = 661

 Score =  105 bits (262), Expect = 2e-21
 Identities = 62/154 (40%), Positives = 78/154 (50%), Gaps = 7/154 (4%)
 Frame = +3

Query: 90  LGAAEGENGDGGFRWWEAGNKTD---GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELH 260
           L   EG   DG   WW  G  T    GE +W TL HNGV FPP Y PHG P++Y   +  
Sbjct: 44  LANEEGGGNDGETEWWTQGTLTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFE 103

Query: 261 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-- 434
           + P  EEVAT +A   + D+   E FR NFF  +R +L   K    I  LE CDFS I  
Sbjct: 104 MTPEEEEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYE 161

Query: 435 --EAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
             +  +E  K++ + EKK     E K   + EAE
Sbjct: 162 WHQREVEKRKSRTREEKK-----ELKRIADEEAE 190

[74][TOP]
>UniRef100_C9ZLY6 DNA topoisomerase IB, large subunit, putative n=2 Tax=Trypanosoma
           brucei RepID=C9ZLY6_TRYBG
          Length = 696

 Score =  105 bits (262), Expect = 2e-21
 Identities = 62/154 (40%), Positives = 78/154 (50%), Gaps = 7/154 (4%)
 Frame = +3

Query: 90  LGAAEGENGDGGFRWWEAGNKTD---GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELH 260
           L   EG   DG   WW  G  T    GE +W TL HNGV FPP Y PHG P++Y   +  
Sbjct: 79  LANEEGGGNDGEAEWWTQGTLTTTKKGEKRWDTLLHNGVLFPPAYVPHGIPILYNQQKFE 138

Query: 261 LPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-- 434
           + P  EEVAT +A   + D+   E FR NFF  +R +L   K    I  LE CDFS I  
Sbjct: 139 MTPEEEEVATMFAVLREHDYYRNEVFRRNFFQSWREILDKRKHP--IRCLELCDFSAIYE 196

Query: 435 --EAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
             +  +E  K++ + EKK     E K   + EAE
Sbjct: 197 WHQREVEKRKSRTREEKK-----ELKRIADEEAE 225

[75][TOP]
>UniRef100_O13463 Topoisomerase I n=1 Tax=Emericella nidulans RepID=O13463_EMENI
          Length = 871

 Score =  105 bits (262), Expect = 2e-21
 Identities = 65/146 (44%), Positives = 83/146 (56%), Gaps = 14/146 (9%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L P AEEVA F+ 
Sbjct: 226 YKWWEGPTKGDGTIKWTTLEHNGVVFPPPYEPLPKHVKMKYDGIPVDLHPEAEEVAGFFG 285

Query: 300 SKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCD----FSRIEAH 443
           S L  T H     F+ NFFADF+ +L  T  AK        I    KCD    F   +A 
Sbjct: 286 SMLNSTQHTENPTFQKNFFADFKEILKKTGGAKDQKGNKVDIKEFSKCDSQPIFQYYDAQ 345

Query: 444 LEDEKAKKKAEKKAQTTAERKEAREA 521
            +++KA   AEKK +  AE K+A+EA
Sbjct: 346 RQEKKALPPAEKK-RLKAE-KDAQEA 369

[76][TOP]
>UniRef100_C4R3Z3 Topoisomerase I n=1 Tax=Pichia pastoris GS115 RepID=C4R3Z3_PICPG
          Length = 763

 Score =  105 bits (262), Expect = 2e-21
 Identities = 56/136 (41%), Positives = 81/136 (59%), Gaps = 3/136 (2%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  N  D E+KW +L+HNGV FPPE+ P      L Y+   + LP  AEEVA F+ 
Sbjct: 127 YKWWEENNDND-EIKWHSLKHNGVLFPPEHVPLPSHVKLYYDKKPVDLPIQAEEVACFFG 185

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKV-ITSLEKCDFSRIEAHLEDEKAKKKAE 476
           + L T+H     F++NFF+DF+ ++ +   A V I S +KCDFS+I  H E +K+ KK+ 
Sbjct: 186 AMLNTEHAQNPAFQNNFFSDFKKIVLEHGGANVEIESFDKCDFSKIFDHYETQKSLKKSL 245

Query: 477 KKAQTTAERKEAREAE 524
             AQ    + E  + E
Sbjct: 246 TAAQKREIKSEKDKFE 261

[77][TOP]
>UniRef100_B6ABX7 DNA topoisomerase I, putative n=1 Tax=Cryptosporidium muris RN66
           RepID=B6ABX7_9CRYT
          Length = 660

 Score =  105 bits (261), Expect = 3e-21
 Identities = 50/133 (37%), Positives = 76/133 (57%)
 Frame = +3

Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           +WWE   K +  ++W  LEHNGV F P Y+ H  PLIY+G E+ LP  +EE+AT++A  L
Sbjct: 39  KWWERPAKDESSIQWDYLEHNGVMFAPPYQAHKVPLIYDGKEIELPNESEEIATYWAQIL 98

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
            T+   KE+F  N    F + +          + +KCDFS I+ H ++EK +KK   K Q
Sbjct: 99  DTEWSSKERFVKNAKEAFISSIPKGHILYKNCNWDKCDFSLIKEHFDEEKERKKNMNKEQ 158

Query: 489 TTAERKEAREAEA 527
              +++   E+E+
Sbjct: 159 KEQQKRIKNESES 171

[78][TOP]
>UniRef100_UPI000186E5D8 DNA topoisomerase, putative n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186E5D8
          Length = 961

 Score =  104 bits (260), Expect = 4e-21
 Identities = 64/151 (42%), Positives = 81/151 (53%), Gaps = 9/151 (5%)
 Frame = +3

Query: 84  SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMEL 257
           SP    + E     ++WWE   + DG+ KW  LEH G  F P YE  P      Y+G E+
Sbjct: 393 SPKKVKKEEEQQDVWKWWEEEKREDGK-KWKFLEHKGPLFAPLYERLPKSVKFFYDGKEI 451

Query: 258 HLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE 437
            L   AEEVATFYA  L  D+  KEKF +NFF D+R ++ D K  KVIT L KC+F  + 
Sbjct: 452 SLSEEAEEVATFYAKMLTHDYTTKEKFNTNFFNDWRKVMTD-KERKVITDLSKCNFKPMA 510

Query: 438 AHL----EDEKAKKKAEKKA---QTTAERKE 509
            +     E+ KA  K EKK    Q  A +KE
Sbjct: 511 LYFQEKSEERKAMSKEEKKVIKDQNDAIQKE 541

[79][TOP]
>UniRef100_A9V5T5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5T5_MONBE
          Length = 2575

 Score =  104 bits (260), Expect = 4e-21
 Identities = 60/150 (40%), Positives = 83/150 (55%), Gaps = 2/150 (1%)
 Frame = +3

Query: 102  EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 275
            E E  +   RWWE     DG+ KW TL H G  FPP YEP   G  L+Y+G    L P A
Sbjct: 1847 EPEEEEEIHRWWEEEELPDGQ-KWRTLTHRGPLFPPAYEPLPKGVHLLYDGKPYLLKPEA 1905

Query: 276  EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 455
            EE+A FYA  L  D+V K+ F  NF  D+RA +   +  K +T ++KCDFS I +H +  
Sbjct: 1906 EEIAGFYAMMLTRDYVHKDIFNENFMHDWRANMTPQE-RKDLTDIKKCDFSLIHSHYQQR 1964

Query: 456  KAKKKAEKKAQTTAERKEAREAEAERVRQF 545
               +KA  K     E+++ +EAEA+   ++
Sbjct: 1965 AEARKAASK----EEKEKRKEAEAKLKEEY 1990

[80][TOP]
>UniRef100_C7YQG7 Predicted protein n=1 Tax=Nectria haematococca mpVI 77-13-4
           RepID=C7YQG7_NECH7
          Length = 919

 Score =  104 bits (260), Expect = 4e-21
 Identities = 62/157 (39%), Positives = 83/157 (52%), Gaps = 15/157 (9%)
 Frame = +3

Query: 96  AAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPP 269
           A E    +  F WW    K D  +KW TLEHNGV FPPEYE  P    LIY+G  ++L P
Sbjct: 254 AKESGEEEEEFAWWLEPKKEDDSIKWNTLEHNGVLFPPEYEPMPKHIKLIYDGKPVNLAP 313

Query: 270 AAEEVATFYASKL---QTDHVLKEKFRSNFFADFRAL-----LADTKFAKV-ITSLEKCD 422
             EEVATF+ + +    + H+    FR NFF DF+       + D    KV I SL+KCD
Sbjct: 314 EVEEVATFWVAMMTPASSHHMENPVFRKNFFEDFQEYCKKYGVTDADGKKVQIKSLDKCD 373

Query: 423 FSRIE----AHLEDEKAKKKAEKKAQTTAERKEAREA 521
           F+++     A  E  K K   +++ +    +KEA EA
Sbjct: 374 FTKLADYWLAKAEQNKTKNMTKEEKEAAKAKKEALEA 410

[81][TOP]
>UniRef100_C4JVV4 DNA topoisomerase I n=1 Tax=Uncinocarpus reesii 1704
           RepID=C4JVV4_UNCRE
          Length = 889

 Score =  104 bits (260), Expect = 4e-21
 Identities = 62/140 (44%), Positives = 77/140 (55%), Gaps = 10/140 (7%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG +KWTTLEHNGV FPP YE  P    + Y+G+ + L   AEEVA F+ 
Sbjct: 262 YRWWEDPAKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPITLSLEAEEVAGFFG 321

Query: 300 SKLQTDH-VLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDE 455
           S L + H V    F+ NFF DF A++  T  AK        I   +KCDF  I  + E  
Sbjct: 322 SMLNSTHNVENPTFQKNFFEDFTAIIKKTGGAKNPQGNAVPIKDFKKCDFQPIFEYYE-- 379

Query: 456 KAKKKAEKKAQTTAERKEAR 515
              K+ EKKA   AERK  +
Sbjct: 380 --MKRLEKKALPAAERKRLK 397

[82][TOP]
>UniRef100_Q7YXA0 DNA topoisomerase I subunit A (Fragment) n=1 Tax=Leishmania major
           RepID=Q7YXA0_LEIMA
          Length = 200

 Score =  104 bits (259), Expect = 5e-21
 Identities = 61/147 (41%), Positives = 77/147 (52%), Gaps = 3/147 (2%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGN---KTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           E  +    WWE  N      GE +W TL HNGV FPPEYEPHG P+ Y+G E  + P  E
Sbjct: 22  EINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEE 81

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 458
           EVAT +A   + D+   E F  NFF  +R +L   K    I  LE CDF  I      ++
Sbjct: 82  EVATMFAVMKEHDYYRMEVFWRNFFESWREILG--KRQHPIRRLELCDFEPIYQWYLVQR 139

Query: 459 AKKKAEKKAQTTAERKEAREAEAERVR 539
            KK +  K +  A  KE ++AEAE  R
Sbjct: 140 EKKLSRTKEEKEA-IKEKQDAEAEPYR 165

[83][TOP]
>UniRef100_Q6FVE9 Similar to uniprot|P04786 Saccharomyces cerevisiae YOL006c TOP1 DNA
           topoisomerase I n=1 Tax=Candida glabrata
           RepID=Q6FVE9_CANGA
          Length = 717

 Score =  104 bits (259), Expect = 5e-21
 Identities = 60/135 (44%), Positives = 78/135 (57%), Gaps = 5/135 (3%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  +K D  +KWTTLEHNGV FPP YE  P    L YEG  + LP  AEEVA F+A
Sbjct: 79  YKWWEEQDKDD-TIKWTTLEHNGVLFPPPYEALPSHVKLYYEGNPVDLPLEAEEVAGFFA 137

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLAD---TKFAKVITSLEKCDFSRIEAHLEDEKAKKK 470
             L+T H     F+ NFF DF+ +L D   T+    I S ++ DFS     + D   + K
Sbjct: 138 HLLETPHAQNPVFQKNFFEDFKHVLNDAGGTQNGIEIESFDRMDFSA----MHDYFVQLK 193

Query: 471 AEKKAQTTAERKEAR 515
            EKK+ T  ++KE R
Sbjct: 194 EEKKSMTAMQKKEIR 208

[84][TOP]
>UniRef100_P30181 DNA topoisomerase 1 n=1 Tax=Arabidopsis thaliana RepID=TOP1_ARATH
          Length = 916

 Score =  104 bits (259), Expect = 5e-21
 Identities = 56/131 (42%), Positives = 80/131 (61%), Gaps = 1/131 (0%)
 Frame = +3

Query: 156 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335
           DG+ KWTTL HNGV FPP Y+PHG  ++Y+G  + L    EEVAT +A   +TD+  K +
Sbjct: 366 DGQKKWTTLVHNGVIFPPPYKPHGIKILYKGKPVDLTIEQEEVATMFAVMRETDYYTKPQ 425

Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEA 512
           FR NF+ D+R LL       VI  L+ CDF+ I E HLE+     K +KK  +T E+K  
Sbjct: 426 FRENFWNDWRRLLGK---KHVIQKLDDCDFTPIYEWHLEE-----KEKKKQMSTEEKKAL 477

Query: 513 REAEAERVRQF 545
           +E + ++  ++
Sbjct: 478 KEEKMKQEEKY 488

[85][TOP]
>UniRef100_UPI000192545C PREDICTED: similar to topoisomerase (DNA) I, like n=1 Tax=Hydra
           magnipapillata RepID=UPI000192545C
          Length = 726

 Score =  103 bits (258), Expect = 6e-21
 Identities = 68/182 (37%), Positives = 91/182 (50%), Gaps = 13/182 (7%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDR-----------TLSPGRAAGSPLGAAEGENGDGGFRWWEAGNK 152
           +KA+ +V G K K E+            T S  +    P    + E  +  +RWW+    
Sbjct: 102 LKAKVKVEGRKRKNENNDFEDVKKNKNSTQSKNQNKEKPKKVKKEEEEEV-WRWWDEDPH 160

Query: 153 TDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326
            DG +KW TL H G YFPPEYEP        Y+G  + L   AEEVATFYA  L  D+V 
Sbjct: 161 QDG-IKWKTLSHEGPYFPPEYEPMPKNVKFYYDGKPMQLSLEAEEVATFYAKMLDHDYVK 219

Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           K+ F  NFF D+R  +   +   +I SL+KCDF  + A+       K AE+K   T E K
Sbjct: 220 KDIFNENFFEDWRKEMT-AEERNIIKSLDKCDFKEMHAYF-----MKCAEEKRNMTKEEK 273

Query: 507 EA 512
           +A
Sbjct: 274 QA 275

[86][TOP]
>UniRef100_Q00XV7 Putative DNA topoisomerase I (ISS) n=1 Tax=Ostreococcus tauri
           RepID=Q00XV7_OSTTA
          Length = 783

 Score =  103 bits (258), Expect = 6e-21
 Identities = 56/133 (42%), Positives = 78/133 (58%), Gaps = 9/133 (6%)
 Frame = +3

Query: 147 NKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           N+++G VK      W TLEHNGV FPP YEPHG PL Y+G ++ L P  EE+A F+A   
Sbjct: 223 NRSEGYVKKGAVIMWKTLEHNGVVFPPPYEPHGVPLTYDGQDVKLLPHEEEIAGFFAVMK 282

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAH---LEDEKAKKKAEK 479
            TD+  K  F  NF   F+  LA+   A  IT   KCDF+++  H   + +EK +  +E+
Sbjct: 283 DTDYAQKAVFVKNFMDGFKEALANGPHA-FITDFRKCDFTKMYNHFAKIREEKKQMTSEE 341

Query: 480 KAQTTAERKEARE 518
           K +  AE+ +A E
Sbjct: 342 KKRIKAEKDKAEE 354

[87][TOP]
>UniRef100_B7ZWU7 Putative uncharacterized protein n=1 Tax=Zea mays
           RepID=B7ZWU7_MAIZE
          Length = 574

 Score =  103 bits (258), Expect = 6e-21
 Identities = 56/130 (43%), Positives = 75/130 (57%), Gaps = 1/130 (0%)
 Frame = +3

Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338
           G  KWTTLEHNGV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  K  F
Sbjct: 28  GGKKWTTLEHNGVIFPPPYKPHGVKMLYNGKPIDLTPEQEEVATMFAVMKDTDYAAKPTF 87

Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515
             NFF D+R +L       +I + E CDF+ I E HL     ++K  KK  TT E+K  R
Sbjct: 88  IDNFFTDWRKVLGKN---HIIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLR 139

Query: 516 EAEAERVRQF 545
           E + ++  ++
Sbjct: 140 EDKLKQEEKY 149

[88][TOP]
>UniRef100_Q6CUB9 KLLA0C06116p n=1 Tax=Kluyveromyces lactis RepID=Q6CUB9_KLULA
          Length = 785

 Score =  103 bits (258), Expect = 6e-21
 Identities = 57/136 (41%), Positives = 80/136 (58%), Gaps = 8/136 (5%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           F+WWE G+K D  +KWTTL+HNGV FP  YE  P    L Y G  + LPP AEEVA F+A
Sbjct: 146 FKWWENGDKEDDTIKWTTLKHNGVIFPSTYEPLPAHVKLYYNGKPVDLPPQAEEVAGFFA 205

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAK---VITSLEKCDFSRIEAHLEDEKAKKK 470
           + L++DHV    F+ NF  DF  +L +   A+    I    K DF++I  + + +K +KK
Sbjct: 206 AILESDHVKIPTFQKNFLHDFLQVLKENGGARNGVQIKEFGKLDFTKIFEYFQVQKEQKK 265

Query: 471 ---AEKKAQTTAERKE 509
               ++K Q   E++E
Sbjct: 266 QLSPQEKKQLRLEKEE 281

[89][TOP]
>UniRef100_A6S3Q9 Putative uncharacterized protein n=1 Tax=Botryotinia fuckeliana
           B05.10 RepID=A6S3Q9_BOTFB
          Length = 912

 Score =  103 bits (258), Expect = 6e-21
 Identities = 66/183 (36%), Positives = 88/183 (48%), Gaps = 10/183 (5%)
 Frame = +3

Query: 9   KAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEH 188
           KA  +   GK K E  T    +         E E  D  +RWW+A  K D  +KW TL+H
Sbjct: 231 KAAPKKVNGKVKAEPDTKVKAKKD-------ESEEADEVYRWWDAPKKEDDSIKWETLQH 283

Query: 189 NGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNFFAD 359
           NGV FPPEYE  P    L Y+G+ L L   +EE+A F+ + L + H V    F+ NFF D
Sbjct: 284 NGVVFPPEYEPLPKNVKLRYDGIPLTLSLESEEIAGFFGAMLNSTHNVENPTFQKNFFKD 343

Query: 360 FRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
           F   +  T  AK        I    K DF  I  + + +  ++KA   A+  AE+    E
Sbjct: 344 FTDSVKKTGGAKDKEGNKVAIKDFSKLDFKPIFEYYDGKSTERKARSAAEKKAEKALKDE 403

Query: 519 AEA 527
           AEA
Sbjct: 404 AEA 406

[90][TOP]
>UniRef100_Q6T721 Mitochondrial topoisomerase I n=1 Tax=Danio rerio
           RepID=Q6T721_DANRE
          Length = 600

 Score =  103 bits (257), Expect = 8e-21
 Identities = 56/138 (40%), Positives = 79/138 (57%), Gaps = 2/138 (1%)
 Frame = +3

Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308
           WE G   D  VKW++LEH G YF P+YEP        Y+G ++ L P  EE+ATFYA  L
Sbjct: 42  WEEGKSCDA-VKWSSLEHKGPYFAPDYEPLPANICFYYDGQQVKLSPLTEEIATFYAKML 100

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
             ++  KE F+ NFF D+R  +   +  K+IT+L KCDF+ I  +  +     KAE+K  
Sbjct: 101 DHEYTTKEVFQKNFFKDWRKEMTKEE-RKLITTLSKCDFTHIHKYFVE-----KAEEKKN 154

Query: 489 TTAERKEAREAEAERVRQ 542
            T E K+  + EA R+ +
Sbjct: 155 MTKEEKQVLKDEAARLME 172

[91][TOP]
>UniRef100_C6KE75 DNA topoisomerase I n=1 Tax=Zea mays RepID=C6KE75_MAIZE
          Length = 904

 Score =  103 bits (256), Expect = 1e-20
 Identities = 56/130 (43%), Positives = 74/130 (56%), Gaps = 1/130 (0%)
 Frame = +3

Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338
           G  KWTTLEHNGV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  K  F
Sbjct: 358 GGKKWTTLEHNGVIFPPPYKPHGVKMLYNGKPVDLTPEQEEVATMFAVMKDTDYAAKPTF 417

Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515
             NFF D+R +L       +I + E CDF+ I E HL     ++K  KK  TT E+K  R
Sbjct: 418 IDNFFTDWRKVLGKN---HIIKNFELCDFTPIYEWHL-----REKERKKQMTTEEKKTLR 469

Query: 516 EAEAERVRQF 545
           E   ++  ++
Sbjct: 470 EDNLKQEEKY 479

[92][TOP]
>UniRef100_B9I1A0 Predicted protein (Fragment) n=1 Tax=Populus trichocarpa
           RepID=B9I1A0_POPTR
          Length = 860

 Score =  103 bits (256), Expect = 1e-20
 Identities = 56/132 (42%), Positives = 78/132 (59%), Gaps = 1/132 (0%)
 Frame = +3

Query: 153 TDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332
           +DG+ KW TL HNGV FPP Y+PHG  ++Y+G  + L P  EEVAT +A    T++V K 
Sbjct: 312 SDGQKKWKTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMKDTEYVQKP 371

Query: 333 KFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKE 509
           +F  NF+ D+R LL       VI  LE CDF+ I E H      K+K +KK  +T E+K 
Sbjct: 372 QFLQNFWNDWRTLLGKN---HVIQKLEACDFNPIYEWH-----QKEKEKKKQMSTEEKKA 423

Query: 510 AREAEAERVRQF 545
            RE + ++   +
Sbjct: 424 VREEKLKQEEMY 435

[93][TOP]
>UniRef100_B2DDA4 Topoisomerase I n=1 Tax=Ophiorrhiza pumila RepID=B2DDA4_9GENT
          Length = 926

 Score =  103 bits (256), Expect = 1e-20
 Identities = 54/119 (45%), Positives = 72/119 (60%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV FPP Y+PHG  ++Y+   L L P  EEVAT +A+ L TD++ K +F+ N
Sbjct: 382 KWTTLVHNGVMFPPPYKPHGVKMLYKRQPLTLTPEQEEVATMFAAMLDTDYMNKPRFKEN 441

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
           FF+D++ +L        I +LE CDF  I    + EK     EKK Q T E K+A + E
Sbjct: 442 FFSDWKKILGKN---HTIQNLEDCDFGPIYEWHQQEK-----EKKKQMTTEEKKALKEE 492

[94][TOP]
>UniRef100_Q969P6 DNA topoisomerase I, mitochondrial n=1 Tax=Homo sapiens
           RepID=TOP1M_HUMAN
          Length = 601

 Score =  103 bits (256), Expect = 1e-20
 Identities = 63/152 (41%), Positives = 83/152 (54%), Gaps = 2/152 (1%)
 Frame = +3

Query: 93  GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLP 266
           G+   + G G    WE     DG VKW  LEH G YF P YEP   G    YEG  + L 
Sbjct: 30  GSRRTQKGSGAR--WEKEKHEDG-VKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLS 86

Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446
            AAEEVATFY   L  ++  KE FR NFF D+R  +A  +  +VI SL+KCDF+ I  + 
Sbjct: 87  VAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYF 145

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
            D+ A +K       + E K+  + EAE+++Q
Sbjct: 146 VDKAAARKV-----LSREEKQKLKEEAEKLQQ 172

[95][TOP]
>UniRef100_UPI00017582B6 PREDICTED: similar to conserved hypothetical protein n=1
           Tax=Tribolium castaneum RepID=UPI00017582B6
          Length = 936

 Score =  102 bits (255), Expect = 1e-20
 Identities = 54/133 (40%), Positives = 80/133 (60%), Gaps = 4/133 (3%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE   K DG+ KW  LEH G  F P YEP        Y+G E+ L P AEEVA+FY+
Sbjct: 376 WKWWEEEKKDDGK-KWKFLEHKGPVFAPPYEPLPDHVKFYYDGKEMKLTPEAEEVASFYS 434

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED--EKAKKKA 473
             L  D+  KE F +NFF D+R ++++++  KVI  L+KC+F  + A+  D  EK + + 
Sbjct: 435 KMLDHDYTTKEVFNNNFFKDWRKVMSESE-RKVIKDLKKCNFKSMHAYYMDLAEKNRNRT 493

Query: 474 EKKAQTTAERKEA 512
           +++ Q   E+ EA
Sbjct: 494 KEEKQALKEKNEA 506

[96][TOP]
>UniRef100_C5YGY1 Putative uncharacterized protein Sb07g003610 n=1 Tax=Sorghum
           bicolor RepID=C5YGY1_SORBI
          Length = 921

 Score =  102 bits (255), Expect = 1e-20
 Identities = 55/127 (43%), Positives = 74/127 (58%), Gaps = 1/127 (0%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTLEHNGV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  K  F  N
Sbjct: 378 KWTTLEHNGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYAGKPTFIDN 437

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
           FF D+R +L       +I   E CDF+ I E HL     ++K +KK  TT E+K  RE +
Sbjct: 438 FFTDWRKILGKN---HIIKKFELCDFTPIYEWHL-----REKEKKKQMTTEEKKALREEK 489

Query: 525 AERVRQF 545
            ++  ++
Sbjct: 490 LKQEEKY 496

[97][TOP]
>UniRef100_A7EXF7 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum
           1980 UF-70 RepID=A7EXF7_SCLS1
          Length = 911

 Score =  102 bits (255), Expect = 1e-20
 Identities = 67/185 (36%), Positives = 87/185 (47%), Gaps = 10/185 (5%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           KVK E      KAK E                 E E  D  +RWW+A  K D  +KW TL
Sbjct: 238 KVKPEPDTKKAKAKKE-----------------ESEEADEVYRWWDAPKKEDDSIKWETL 280

Query: 183 EHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDH-VLKEKFRSNFF 353
           +HNGV FPPEYE  P    L Y+G+ L L   +EE+A F+ + L + H V    F+ NFF
Sbjct: 281 QHNGVVFPPEYEPLPKNVKLGYDGIPLTLSLESEEIAGFFGAMLNSTHNVENPTFQKNFF 340

Query: 354 ADFRALLADTKFAK-------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512
            DF   +  T  AK        I    K DF  I  + + +  ++KA   A+  AE+   
Sbjct: 341 KDFTDSVKKTGGAKDKDGNKVAIKDFSKLDFKPIFEYYDGKSTERKARSAAEKKAEKAAK 400

Query: 513 REAEA 527
            EAEA
Sbjct: 401 DEAEA 405

[98][TOP]
>UniRef100_B2DDA7 Topoisomerase I n=1 Tax=Camptotheca acuminata RepID=B2DDA7_CAMAC
          Length = 894

 Score =  102 bits (253), Expect = 2e-20
 Identities = 55/120 (45%), Positives = 71/120 (59%), Gaps = 3/120 (2%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KW TL HNGV FPP Y+PHG  ++Y+G  + L P  EEVAT +A  L TD++ K KF+ N
Sbjct: 351 KWNTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKSKFKEN 410

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK---AEKKAQTTAERKEARE 518
           F  D+R +L       VI +LE CDF+ I    + EK KKK   AE+K     ER +  E
Sbjct: 411 FMDDWRKILGKN---HVIQNLEDCDFTPIYEWHQREKEKKKKMTAEEKKVLKEERLKQEE 467

[99][TOP]
>UniRef100_UPI0000DB758E PREDICTED: similar to DNA topoisomerase I n=1 Tax=Apis mellifera
           RepID=UPI0000DB758E
          Length = 973

 Score =  101 bits (252), Expect = 3e-20
 Identities = 55/142 (38%), Positives = 78/142 (54%), Gaps = 2/142 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE   K DG  KWT LEH G  F P YEP        Y G E+ L    EEVATFYA
Sbjct: 429 WKWWEEEKKNDG-TKWTFLEHKGPVFAPPYEPLPPDVNFYYNGKEMKLSQDTEEVATFYA 487

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  K  F SNFF D+R ++ +++  K++  L KC+F  I A+      +K  E+
Sbjct: 488 RMLDHDYTTKPAFNSNFFHDWREVMTESERTKIV-DLSKCNFKEIHAYF----IQKSEER 542

Query: 480 KAQTTAERKEAREAEAERVRQF 545
           KA T  E+++ +E   E  +++
Sbjct: 543 KAMTKEEKQKIKEKNEEIQKEY 564

[100][TOP]
>UniRef100_B2DDA6 Topoisomerase I n=1 Tax=Ophiorrhiza japonica RepID=B2DDA6_9GENT
          Length = 927

 Score =  101 bits (252), Expect = 3e-20
 Identities = 52/126 (41%), Positives = 74/126 (58%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV FPP Y PHG  ++Y+   + L P  EEVAT +A  L TD++ K +F+ N
Sbjct: 383 KWTTLVHNGVIFPPPYNPHGVKMLYKRQPITLTPEQEEVATMFAVMLDTDYMNKPRFKEN 442

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           FF+D++ +L        I +LE CDF  I    + EK K    KK  TT E+K  +E + 
Sbjct: 443 FFSDWKKMLGKN---HTIQNLEDCDFGPIYEWHQQEKEK----KKQMTTEEKKALKEDKL 495

Query: 528 ERVRQF 545
           ++  ++
Sbjct: 496 QQEEKY 501

[101][TOP]
>UniRef100_P41512 DNA topoisomerase 1 n=1 Tax=Xenopus laevis RepID=TOP1_XENLA
          Length = 829

 Score =  101 bits (252), Expect = 3e-20
 Identities = 65/188 (34%), Positives = 97/188 (51%), Gaps = 8/188 (4%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSP---GRAAGSPLGAAEGE---NGDGGFRWWEAGNKTDGE 164
           K+K+E    G K K E+  + P    +A G+  G  + +     +  ++WWE     DG 
Sbjct: 212 KIKSEDDKKGKKRKQEEEDIKPKKKSKAKGNEEGVKKKKVKKEEEEKWKWWEEERHRDG- 270

Query: 165 VKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338
           +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A  L  ++  K+ F
Sbjct: 271 IKWKFLEHKGPVFAPPYEPVPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIF 330

Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
           R NFF D++  +  T    +IT+L KCDF+ +  +      K+++E +   T E K   +
Sbjct: 331 RKNFFKDWKKEMT-TDERNLITNLSKCDFNAMSLYF-----KEQSEARKNMTKEEKLKIK 384

Query: 519 AEAERVRQ 542
           AE ER+ Q
Sbjct: 385 AENERLLQ 392

[102][TOP]
>UniRef100_A9Q1D5 DNA topoisomerase I, mitochondrial n=1 Tax=Pan troglodytes
           RepID=TOP1M_PANTR
          Length = 601

 Score =  101 bits (251), Expect = 4e-20
 Identities = 60/148 (40%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
 Frame = +3

Query: 93  GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLP 266
           G+   + G G    WE     DG VKW  LEH G YF P YEP   G    YEG  + L 
Sbjct: 30  GSRRTQKGSGAR--WEKEKHEDG-VKWRQLEHKGPYFAPPYEPLPDGVRFFYEGKPVRLS 86

Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446
            AAEEVATFY   L  ++  KE FR NFF D+R  +A  +  +VI SL+KCDF+ I  + 
Sbjct: 87  VAAEEVATFYGRMLGHEYTTKEVFRKNFFNDWRKEMA-VEEREVIKSLDKCDFTEIHRYF 145

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAE 530
            D+ A +K   + +    ++EA + + E
Sbjct: 146 VDKAAARKVLSREEKQKLKEEAEKLQRE 173

[103][TOP]
>UniRef100_UPI00015B4D8F PREDICTED: similar to DNA topoisomerase type I n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B4D8F
          Length = 1019

 Score =  100 bits (250), Expect = 5e-20
 Identities = 58/140 (41%), Positives = 77/140 (55%), Gaps = 6/140 (4%)
 Frame = +3

Query: 84  SPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMEL 257
           SP    + E     ++WWE   K DG  KW  LEH G  F PEYEP        Y G E+
Sbjct: 445 SPKKKKKEEEEPEVWKWWEEEKKNDG-TKWHFLEHKGPVFAPEYEPLPPSVKFYYNGKEM 503

Query: 258 HLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIE 437
            L    EEVATFYA  L+ D+  K+ F  NFF D+R ++ +++ AK IT L+KC+F+ + 
Sbjct: 504 KLTQDTEEVATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAK-ITDLKKCNFTEMH 562

Query: 438 AHL----EDEKAKKKAEKKA 485
            +     E+ KA  K EKKA
Sbjct: 563 KYFIMKSEERKAMSKEEKKA 582

[104][TOP]
>UniRef100_O60013 DNA topoisomerase I n=1 Tax=Pneumocystis carinii RepID=O60013_PNECA
          Length = 763

 Score =  100 bits (250), Expect = 5e-20
 Identities = 61/174 (35%), Positives = 95/174 (54%), Gaps = 3/174 (1%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLE 185
           +K E+++   K K++++ L+           ++ E  D  ++WWE   + DG +KW TLE
Sbjct: 91  IKTEKKLKK-KHKSQEKELNSEELKNEESLRSKEEEED--YKWWEQ-QQGDGTIKWKTLE 146

Query: 186 HNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE-KFRSNFFA 356
           HNGV FPP YE  P    + Y+G  + LPP AEEVA F+ + L ++  +K   F+ NFF 
Sbjct: 147 HNGVLFPPPYEPLPSYVKMKYKGEPISLPPEAEEVAGFFGAILSSEQYVKNPTFQKNFFH 206

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
           DF+     T    +    E CDF+ +  + E    KKK EKK ++  E+K+ +E
Sbjct: 207 DFQETCKKTNAPVIPEKFEYCDFTPMFEYFE----KKKEEKKNKSKEEKKKIKE 256

[105][TOP]
>UniRef100_Q9ZSC8 Topoisomerase I n=1 Tax=Nicotiana tabacum RepID=Q9ZSC8_TOBAC
          Length = 852

 Score =  100 bits (249), Expect = 7e-20
 Identities = 54/125 (43%), Positives = 75/125 (60%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV FPP Y+PHG  ++Y+G  + L P  EEVAT YA  L TD++ K +F+ N
Sbjct: 334 KWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMSKLQFKEN 393

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           F  D+R +L       VI +L+ CDF+ I      E+   + EKK Q + +RK  R    
Sbjct: 394 FMNDWRKILGKN---HVIQNLDDCDFTPIY-----ERPSSEKEKKKQMSTKRK--RPLRE 443

Query: 528 ERVRQ 542
           E+++Q
Sbjct: 444 EKLKQ 448

[106][TOP]
>UniRef100_B4L533 GI21653 n=1 Tax=Drosophila mojavensis RepID=B4L533_DROMO
          Length = 1043

 Score =  100 bits (249), Expect = 7e-20
 Identities = 62/172 (36%), Positives = 84/172 (48%), Gaps = 2/172 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           KVK E  +     K E    SP + +       E E     +RWWE   + DG VKWTTL
Sbjct: 451 KVKKESEI-----KQEPSQTSPTKRSRKDKKEEEEEV----WRWWEEEKREDG-VKWTTL 500

Query: 183 EHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YE  P      Y+G  + L    EE ATFYA  L  D+  K+ F +NFF 
Sbjct: 501 EHKGPVFAPPYERVPRNVRFFYDGKPMELSEETEEAATFYAKMLNHDYCTKDVFNNNFFK 560

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512
           DFR  +   K  ++I    KC+F  +  + + E  K+KA  K +  A++ E+
Sbjct: 561 DFRKTMT-PKEKEIIKDFRKCNFQEMFEYFQAESEKRKAATKEEKLAKKVES 611

[107][TOP]
>UniRef100_B3MR83 GF21232 n=1 Tax=Drosophila ananassae RepID=B3MR83_DROAN
          Length = 990

 Score =  100 bits (249), Expect = 7e-20
 Identities = 52/130 (40%), Positives = 71/130 (54%), Gaps = 2/130 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   + DG VKW+TLEH G  F P YE  P      Y+G  L L    EE ATFYA
Sbjct: 444 WRWWEEEKREDG-VKWSTLEHKGPVFAPPYERVPRNVRFYYDGKPLELSEETEEAATFYA 502

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  K+ F +NFF DFR  +  +K  ++I    KC+F  +  + + E  K+KA  
Sbjct: 503 KMLNHDYCTKDVFNTNFFKDFRKSMT-SKEKEIIKDFRKCNFQEMHNYFQAESEKRKAAT 561

Query: 480 KAQTTAERKE 509
           K +  A++ E
Sbjct: 562 KEEKLAKKNE 571

[108][TOP]
>UniRef100_UPI000198447D PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI000198447D
          Length = 883

 Score =  100 bits (248), Expect = 9e-20
 Identities = 57/126 (45%), Positives = 70/126 (55%)
 Frame = +3

Query: 147 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326
           N  +G+ KWTTLEHNGV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  
Sbjct: 334 NSGEGQ-KWTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYAT 392

Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           K +F  NF  D+R  L       VI   E CDF+ I    E EK     EKK Q T E K
Sbjct: 393 KPRFIENFMNDWRVRLGKN---HVIKKFELCDFTPIYEWHEKEK-----EKKKQMTTEEK 444

Query: 507 EAREAE 524
           +A + E
Sbjct: 445 KALKEE 450

[109][TOP]
>UniRef100_Q6IQI8 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q6IQI8_DANRE
          Length = 469

 Score =  100 bits (248), Expect = 9e-20
 Identities = 70/182 (38%), Positives = 96/182 (52%), Gaps = 2/182 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K E      K KT+D+    G  A      A+ E  +  ++WWE    TDG VKW  L
Sbjct: 159 KRKQEEEDIKPKKKTKDKK---GEVATDGKKKAKKEPEEK-WKWWEEERYTDG-VKWKFL 213

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP        Y+G  + L P AEEVATF++  L  ++  K+ FR NFF 
Sbjct: 214 EHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFRKNFFK 273

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536
           D+R  +   + +K IT L KCDFS +  +    KA+ +A +KA T  E+ + +E E ER+
Sbjct: 274 DWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKE-ENERI 327

Query: 537 RQ 542
            Q
Sbjct: 328 LQ 329

[110][TOP]
>UniRef100_Q1ED17 Topoisomerase (DNA) I, like n=1 Tax=Danio rerio RepID=Q1ED17_DANRE
          Length = 758

 Score =  100 bits (248), Expect = 9e-20
 Identities = 70/182 (38%), Positives = 96/182 (52%), Gaps = 2/182 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K E      K KT+D+    G  A      A+ E  +  ++WWE    TDG VKW  L
Sbjct: 159 KRKQEEEDIKPKKKTKDKK---GEVATDGKKKAKKEPEEK-WKWWEEERYTDG-VKWKFL 213

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP        Y+G  + L P AEEVATF++  L  ++  K+ FR NFF 
Sbjct: 214 EHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFRKNFFK 273

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536
           D+R  +   + +K IT L KCDFS +  +    KA+ +A +KA T  E+ + +E E ER+
Sbjct: 274 DWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKLKIKE-ENERI 327

Query: 537 RQ 542
            Q
Sbjct: 328 LQ 329

[111][TOP]
>UniRef100_A7PX10 Chromosome chr12 scaffold_36, whole genome shotgun sequence n=1
           Tax=Vitis vinifera RepID=A7PX10_VITVI
          Length = 789

 Score =  100 bits (248), Expect = 9e-20
 Identities = 57/126 (45%), Positives = 70/126 (55%)
 Frame = +3

Query: 147 NKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVL 326
           N  +G+ KWTTLEHNGV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  
Sbjct: 240 NSGEGQ-KWTTLEHNGVIFPPPYKPHGVKMLYNGRPVDLTPEQEEVATMFAVMKDTDYAT 298

Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
           K +F  NF  D+R  L       VI   E CDF+ I    E EK     EKK Q T E K
Sbjct: 299 KPRFIENFMNDWRVRLGKN---HVIKKFELCDFTPIYEWHEKEK-----EKKKQMTTEEK 350

Query: 507 EAREAE 524
           +A + E
Sbjct: 351 KALKEE 356

[112][TOP]
>UniRef100_Q494M1 Topoisomerase 1, isoform C n=1 Tax=Drosophila melanogaster
           RepID=Q494M1_DROME
          Length = 974

 Score =  100 bits (248), Expect = 9e-20
 Identities = 57/158 (36%), Positives = 79/158 (50%), Gaps = 2/158 (1%)
 Frame = +3

Query: 42  KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 218
           K  +  +SPG+   +     E E     +RWWE   + DG VKW+TLEH G  F P YE 
Sbjct: 404 KEPEPAVSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 458

Query: 219 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395
            P      Y+G  L L    EE ATFYA  L  D+  KE F +NFF DFR  +   +  +
Sbjct: 459 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 517

Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           +I    KC+F  +  + + E  K+KA  K +   ++ E
Sbjct: 518 IIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 555

[113][TOP]
>UniRef100_B5DMS2 GA24044 n=1 Tax=Drosophila pseudoobscura pseudoobscura
           RepID=B5DMS2_DROPS
          Length = 1054

 Score =  100 bits (248), Expect = 9e-20
 Identities = 59/174 (33%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
 Frame = +3

Query: 15  ERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNG 194
           ++++    ++ +   +SP +  G+       E  +  +RWWE   + DG VKW+TLEH G
Sbjct: 463 KKKIKKESSEIKTEVVSPTKRKGAK------EEEEEVWRWWEEEKREDG-VKWSTLEHKG 515

Query: 195 VYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRA 368
             F P YE  P      Y+G  L L    EE ATFYA  L  D+  K+ F +NFF DFR 
Sbjct: 516 PVFAPPYERVPRNVRFFYDGRPLDLSEETEEAATFYAKMLNHDYCTKDIFNNNFFKDFRK 575

Query: 369 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
            +  +K  ++I    KC+F  +  + + E     +EK+ Q T E K A++ E E
Sbjct: 576 SMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNENE 623

[114][TOP]
>UniRef100_B4GVZ4 GL14571 n=1 Tax=Drosophila persimilis RepID=B4GVZ4_DROPE
          Length = 1042

 Score =  100 bits (248), Expect = 9e-20
 Identities = 59/174 (33%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
 Frame = +3

Query: 15  ERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNG 194
           ++++    ++ +   +SP +  G+       E  +  +RWWE   + DG VKW+TLEH G
Sbjct: 451 KKKIKKESSEIKTEVVSPTKRKGAK------EEEEEVWRWWEEEKREDG-VKWSTLEHKG 503

Query: 195 VYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRA 368
             F P YE  P      Y+G  L L    EE ATFYA  L  D+  K+ F +NFF DFR 
Sbjct: 504 PVFAPPYERVPRNVRFFYDGRPLDLSEETEEAATFYAKMLNHDYCTKDIFNNNFFKDFRK 563

Query: 369 LLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
            +  +K  ++I    KC+F  +  + + E     +EK+ Q T E K A++ E E
Sbjct: 564 SMT-SKEKEIIKDFRKCNFQEMHEYFQAE-----SEKRKQATKEEKLAKKNENE 611

[115][TOP]
>UniRef100_P30189 DNA topoisomerase 1 n=1 Tax=Drosophila melanogaster
           RepID=TOP1_DROME
          Length = 972

 Score =  100 bits (248), Expect = 9e-20
 Identities = 57/158 (36%), Positives = 79/158 (50%), Gaps = 2/158 (1%)
 Frame = +3

Query: 42  KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 218
           K  +  +SPG+   +     E E     +RWWE   + DG VKW+TLEH G  F P YE 
Sbjct: 402 KEPEPAVSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 456

Query: 219 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395
            P      Y+G  L L    EE ATFYA  L  D+  KE F +NFF DFR  +   +  +
Sbjct: 457 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 515

Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           +I    KC+F  +  + + E  K+KA  K +   ++ E
Sbjct: 516 IIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 553

[116][TOP]
>UniRef100_UPI000194BDF0 PREDICTED: topoisomerase (DNA) I, mitochondrial n=1 Tax=Taeniopygia
           guttata RepID=UPI000194BDF0
          Length = 662

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 54/149 (36%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
 Frame = +3

Query: 102 EGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAA 275
           E +  +  ++WWE   K DG VKW  LEH G YF P YEP        Y+G  L L  A 
Sbjct: 92  EEKEAENKWKWWEEEKKEDG-VKWMQLEHRGPYFVPPYEPLPEDVQFYYDGKPLKLSLAT 150

Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDE 455
           EE+ATFYA  L  ++  KE F++NFF D+R  +   +  ++I  L+KCDF  I  +  ++
Sbjct: 151 EEIATFYAKMLNHEYTTKEIFQNNFFHDWRKEMTSEE-QEIIKELDKCDFGEIHRYFVEK 209

Query: 456 KAKKKAEKKAQTTAERKEAREAEAERVRQ 542
              +K   K     E K+  + EA+++++
Sbjct: 210 NEARKGLPK-----EEKQKLKEEADKIQE 233

[117][TOP]
>UniRef100_UPI0001555600 PREDICTED: similar to mitochondrial topoisomerase I n=1
           Tax=Ornithorhynchus anatinus RepID=UPI0001555600
          Length = 689

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 58/178 (32%), Positives = 93/178 (52%), Gaps = 2/178 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K+K + ++A  K+  + ++ +  ++  S     E E G   ++WWE   + DG VKW  L
Sbjct: 87  KLKKKDKLASRKSSRKGKSKNEEKSERSDKDQKEDE-GASKWKWWEEEKREDG-VKWKQL 144

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G YF P YEP        Y G  + L    EE+ATFY   L  ++  K+ F++NFF+
Sbjct: 145 EHRGPYFAPLYEPLPDHVHFYYNGKPMKLSLVTEEIATFYGKMLDHEYTTKDIFQNNFFS 204

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
           D+R  +   +  K I  LE+CDF+ I  +  D+   +KA  K +    ++EA + + E
Sbjct: 205 DWRKEMTPEE-QKTIKCLEECDFTEIHKYFVDKNEARKALPKEEKQKLKEEAEKLQEE 261

[118][TOP]
>UniRef100_UPI000069E294 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I). n=1
           Tax=Xenopus (Silurana) tropicalis RepID=UPI000069E294
          Length = 786

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 63/189 (33%), Positives = 96/189 (50%), Gaps = 9/189 (4%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAE------GENGDGGFRWWEAGNKTDGE 164
           K+K+E    G K K E+  + P + +       E       +  +  ++WWE     DG 
Sbjct: 175 KIKSEDEKKGKKRKQEEEDIKPKKKSKGKGNEGEVKKKKVKKEEEEKWKWWEEERHADG- 233

Query: 165 VKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338
           +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A  L  ++  K+ F
Sbjct: 234 IKWKFLEHKGPVFAPPYEPLPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIF 293

Query: 339 RSNFFADF-RALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515
           R NFF D+ + + AD +   +IT+L KCDF+ +  +      K+++E +   T E K+  
Sbjct: 294 RKNFFKDWKKEMTADER--NLITNLGKCDFNAMSQYF-----KEQSEARKNMTKEEKQKI 346

Query: 516 EAEAERVRQ 542
           + E ER+ Q
Sbjct: 347 KEENERLLQ 355

[119][TOP]
>UniRef100_A8IDM1 DNA topoisomerase I (Fragment) n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8IDM1_CHLRE
          Length = 586

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 55/132 (41%), Positives = 78/132 (59%), Gaps = 1/132 (0%)
 Frame = +3

Query: 138 EAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTD 317
           E G+   G+V W TL+H GV FPPEYEPHG   +Y+G  + L P  EEVAT +A   +TD
Sbjct: 20  EPGSSKSGQVMWKTLKHAGVLFPPEYEPHGVKPLYDGKPVDLTPDQEEVATMFAVMKETD 79

Query: 318 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTT 494
           ++ K+ F  NF+  F+ +L       VI  L+KCDF+ I + H+   +AKK   K+ +  
Sbjct: 80  YMNKKVFLDNFWEGFKEVLGK---GHVIKDLKKCDFTPIYDWHMAQREAKKGISKEEKDR 136

Query: 495 AERKEAREAEAE 530
             +KE  E EA+
Sbjct: 137 I-KKEKDEKEAK 147

[120][TOP]
>UniRef100_B3NTM5 GG17874 n=1 Tax=Drosophila erecta RepID=B3NTM5_DROER
          Length = 969

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 58/160 (36%), Positives = 80/160 (50%), Gaps = 2/160 (1%)
 Frame = +3

Query: 36  KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEY 215
           K K E   +SP +   + +   E E     +RWWE   + DG VKW+TLEH G  F P Y
Sbjct: 397 KMKKEPEVVSPTKRQKAKVKEEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRY 451

Query: 216 E--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 389
           E  P      Y+G  + L    EE ATFYA  L  D+  KE F +NFF DFR  +  +K 
Sbjct: 452 ERVPRNVRFYYDGKPMELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMT-SKE 510

Query: 390 AKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
            ++I    KC F+ +    + E  K+KA  K +   ++ E
Sbjct: 511 REIIKDFRKCGFNEMFNFFQAESEKRKAATKEEKLIKKNE 550

[121][TOP]
>UniRef100_C7GJV8 Top1p n=1 Tax=Saccharomyces cerevisiae JAY291 RepID=C7GJV8_YEAS2
          Length = 745

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 53/139 (38%), Positives = 82/139 (58%), Gaps = 8/139 (5%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  N+ D  +KW TL+HNGV FPP Y+P      L Y+G  + LPP AEEVA F+A
Sbjct: 107 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 165

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 470
           + L++DH     F+ NFF DF  +L ++        I    +CDF+++  + + +K +KK
Sbjct: 166 ALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKK 225

Query: 471 ---AEKKAQTTAERKEARE 518
              +++K Q   ER++  E
Sbjct: 226 QLTSQEKKQIRLEREKFEE 244

[122][TOP]
>UniRef100_B3LJ50 DNA topoisomerase I n=2 Tax=Saccharomyces cerevisiae
           RepID=B3LJ50_YEAS1
          Length = 769

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 53/139 (38%), Positives = 82/139 (58%), Gaps = 8/139 (5%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  N+ D  +KW TL+HNGV FPP Y+P      L Y+G  + LPP AEEVA F+A
Sbjct: 131 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 189

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 470
           + L++DH     F+ NFF DF  +L ++        I    +CDF+++  + + +K +KK
Sbjct: 190 ALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKK 249

Query: 471 ---AEKKAQTTAERKEARE 518
              +++K Q   ER++  E
Sbjct: 250 QLTSQEKKQIRLEREKFEE 268

[123][TOP]
>UniRef100_P04786 DNA topoisomerase 1 n=3 Tax=Saccharomyces cerevisiae
           RepID=TOP1_YEAST
          Length = 769

 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 53/139 (38%), Positives = 82/139 (58%), Gaps = 8/139 (5%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  N+ D  +KW TL+HNGV FPP Y+P      L Y+G  + LPP AEEVA F+A
Sbjct: 131 YKWWEKENEDD-TIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFA 189

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADT---KFAKVITSLEKCDFSRIEAHLEDEKAKKK 470
           + L++DH     F+ NFF DF  +L ++        I    +CDF+++  + + +K +KK
Sbjct: 190 ALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKK 249

Query: 471 ---AEKKAQTTAERKEARE 518
              +++K Q   ER++  E
Sbjct: 250 QLTSQEKKQIRLEREKFEE 268

[124][TOP]
>UniRef100_Q84ZL5 Os08g0154600 protein n=1 Tax=Oryza sativa Japonica Group
           RepID=Q84ZL5_ORYSJ
          Length = 916

 Score = 99.4 bits (246), Expect = 2e-19
 Identities = 55/123 (44%), Positives = 71/123 (57%), Gaps = 1/123 (0%)
 Frame = +3

Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338
           G  KWTTL H+GV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  K+ F
Sbjct: 370 GGQKWTTLVHSGVIFPPPYKPHGVKMLYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTF 429

Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515
             NFF D+R +L       VI   E CDF+ I E HL ++      EKK Q T+E K+A 
Sbjct: 430 IDNFFTDWRKILGKN---HVIKKFELCDFTPIYEWHLREK------EKKKQMTSEEKKAL 480

Query: 516 EAE 524
           + E
Sbjct: 481 KEE 483

[125][TOP]
>UniRef100_A2YRB7 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group
           RepID=A2YRB7_ORYSI
          Length = 916

 Score = 99.4 bits (246), Expect = 2e-19
 Identities = 55/123 (44%), Positives = 71/123 (57%), Gaps = 1/123 (0%)
 Frame = +3

Query: 159 GEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKF 338
           G  KWTTL H+GV FPP Y+PHG  ++Y G  + L P  EEVAT +A    TD+  K+ F
Sbjct: 370 GGQKWTTLVHSGVIFPPPYKPHGVKILYNGQPVDLTPEQEEVATMFAVMKDTDYASKQTF 429

Query: 339 RSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLEDEKAKKKAEKKAQTTAERKEAR 515
             NFF D+R +L       VI   E CDF+ I E HL ++      EKK Q T+E K+A 
Sbjct: 430 IDNFFTDWRKILGKN---HVIKKFELCDFTPIYEWHLREK------EKKKQMTSEEKKAL 480

Query: 516 EAE 524
           + E
Sbjct: 481 KEE 483

[126][TOP]
>UniRef100_B4NCJ2 GK25865 n=1 Tax=Drosophila willistoni RepID=B4NCJ2_DROWI
          Length = 997

 Score = 99.4 bits (246), Expect = 2e-19
 Identities = 58/170 (34%), Positives = 85/170 (50%), Gaps = 2/170 (1%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLE 185
           +K + +    + + +  T+SP + A       E E     +RWWE   + DG VKW+TLE
Sbjct: 401 MKPKMKKVKKEPEIKSETVSPTKRARKDKKDEEEEV----WRWWEEEKREDG-VKWSTLE 455

Query: 186 HNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFAD 359
           H G  F P YE  P      Y+G  L L    EE ATFYA  L  D+  K+ F +NFF D
Sbjct: 456 HKGPVFAPPYERVPRNVRFFYDGKPLDLTEETEEAATFYAKMLNHDYCTKDVFNTNFFKD 515

Query: 360 FRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           FR  + D +  ++I    KC+F  +    + E  ++KA  K +  A++ E
Sbjct: 516 FRKTMTDRE-KEIIKDFRKCNFQEMFEFFQAESERRKAATKDEKLAKKNE 564

[127][TOP]
>UniRef100_B4ILF9 GM19769 n=1 Tax=Drosophila sechellia RepID=B4ILF9_DROSE
          Length = 970

 Score = 99.4 bits (246), Expect = 2e-19
 Identities = 57/158 (36%), Positives = 79/158 (50%), Gaps = 2/158 (1%)
 Frame = +3

Query: 42  KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE- 218
           K  +  +SPG+   + +   E E     +RWWE   + DG VKW+TLEH G  F P YE 
Sbjct: 400 KEPEPIVSPGKRQKTKVKEEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYER 454

Query: 219 -PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395
            P      Y+G  L L    EE ATFYA  L  D+  KE F +NFF DFR  +   +  +
Sbjct: 455 VPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-RE 513

Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           +I    KC F  +  + + E  K+KA  K +   ++ E
Sbjct: 514 IIKDFRKCGFQEMFNYFQAESEKRKAASKEEKLIKKNE 551

[128][TOP]
>UniRef100_Q4SKE8 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SKE8_TETNG
          Length = 622

 Score = 99.0 bits (245), Expect = 2e-19
 Identities = 59/152 (38%), Positives = 81/152 (53%), Gaps = 6/152 (3%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281
           E     +RWWE     DG VKW  LEH+G YFPPEY+P        Y+G ++ L  AAEE
Sbjct: 23  EEEQSRWRWWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEE 81

Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 449
           VA F+A  L  ++  K+ FR NFF D+R  + D +   +I  L+KCDF  I    +A +E
Sbjct: 82  VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 140

Query: 450 DEKAKKKAEKKAQTTAERKEAREAEAERVRQF 545
             K   K EK       RK  +EA  + + ++
Sbjct: 141 ARKNMSKEEKLVCNIQFRKVLKEANQKILDEY 172

[129][TOP]
>UniRef100_Q8IR39 Topoisomerase 1, isoform B n=1 Tax=Drosophila melanogaster
           RepID=Q8IR39_DROME
          Length = 581

 Score = 99.0 bits (245), Expect = 2e-19
 Identities = 56/152 (36%), Positives = 77/152 (50%), Gaps = 2/152 (1%)
 Frame = +3

Query: 60  LSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFP 233
           +SPG+   +     E E     +RWWE   + DG VKW+TLEH G  F P YE  P    
Sbjct: 17  VSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVR 71

Query: 234 LIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLE 413
             Y+G  L L    EE ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    
Sbjct: 72  FYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFR 130

Query: 414 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           KC+F  +  + + E  K+KA  K +   ++ E
Sbjct: 131 KCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 162

[130][TOP]
>UniRef100_C6TPA7 AT12251p n=1 Tax=Drosophila melanogaster RepID=C6TPA7_DROME
          Length = 581

 Score = 99.0 bits (245), Expect = 2e-19
 Identities = 56/152 (36%), Positives = 77/152 (50%), Gaps = 2/152 (1%)
 Frame = +3

Query: 60  LSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFP 233
           +SPG+   +     E E     +RWWE   + DG VKW+TLEH G  F P YE  P    
Sbjct: 17  VSPGKRQKAKAKVEEEEV----WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVR 71

Query: 234 LIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLE 413
             Y+G  L L    EE ATFYA  L  D+  KE F +NFF DFR  +   +  ++I    
Sbjct: 72  FYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPRE-REIIKDFR 130

Query: 414 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           KC+F  +  + + E  K+KA  K +   ++ E
Sbjct: 131 KCNFQEMFNYFQAESEKRKAASKEEKLIKKNE 162

[131][TOP]
>UniRef100_Q07050 DNA topoisomerase 1 n=1 Tax=Cricetulus griseus RepID=TOP1_CRIGR
          Length = 767

 Score = 99.0 bits (245), Expect = 2e-19
 Identities = 57/171 (33%), Positives = 86/171 (50%), Gaps = 2/171 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K E    G   KT+++      A          +  +  ++WWE     +G +KW  L
Sbjct: 164 KRKLEEEEDGKLKKTKNKDKDKKGAESDNKKKKPKKEEEQKWKWWEEERYPEG-IKWKFL 222

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP   G    Y+G  + L P AEEVATF+A  L  ++  KE FR NFF 
Sbjct: 223 EHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFK 282

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           D+R  + + +   VIT+L KCDF+++  + +D+   +K   K +    ++E
Sbjct: 283 DWRKEMTNDE-KNVITNLSKCDFTQMSQYFKDQSEARKQMSKEEKLKIKEE 332

[132][TOP]
>UniRef100_Q9FJ79 DNA topoisomerase I n=1 Tax=Arabidopsis thaliana RepID=Q9FJ79_ARATH
          Length = 917

 Score = 98.6 bits (244), Expect = 3e-19
 Identities = 55/129 (42%), Positives = 76/129 (58%)
 Frame = +3

Query: 156 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335
           DG+ KW TL+HNGV FPP Y+ HG  ++++G  + L P  EEVAT +A   +T++  K K
Sbjct: 364 DGQKKWKTLQHNGVIFPPPYKRHGVKILFQGKPVDLTPEQEEVATMFAVMRETEYYKKPK 423

Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515
           FR NF+ D+R LL       +I SL+ CDF+ I      EK     E K Q TAE K  R
Sbjct: 424 FRENFWNDWRKLLGKN---HMIKSLDDCDFTPIYEWYMQEK-----ETKKQMTAEEK--R 473

Query: 516 EAEAERVRQ 542
             + E+++Q
Sbjct: 474 IVKEEKLKQ 482

[133][TOP]
>UniRef100_C1FD86 DNA topoisomerase I n=1 Tax=Micromonas sp. RCC299
           RepID=C1FD86_9CHLO
          Length = 635

 Score = 98.6 bits (244), Expect = 3e-19
 Identities = 57/145 (39%), Positives = 79/145 (54%), Gaps = 3/145 (2%)
 Frame = +3

Query: 93  GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPA 272
           G+A+ +        W A  K   +  W+TLEHNGV FPP Y+ HG PL+Y+G ++ L P 
Sbjct: 88  GSAKKKTKRADHEPWRA--KRGAKQMWSTLEHNGVVFPPPYQAHGIPLVYDGHDVKLLPH 145

Query: 273 AEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLED 452
            EEVATF+A    TD+  K+ F  NFF  F+  L        I   +KCDF++I      
Sbjct: 146 EEEVATFFAVMKDTDYAQKDIFVKNFFDGFKKTLRGGPHG-FIKDFKKCDFTKIYMWNLQ 204

Query: 453 EKAKKK---AEKKAQTTAERKEARE 518
           E+ +KK   AE+K +  AE+  A E
Sbjct: 205 ERERKKSVSAEEKRKVKAEQAAAEE 229

[134][TOP]
>UniRef100_B2DDA5 Topoisomerase I n=1 Tax=Ophiorrhiza liukiuensis RepID=B2DDA5_9GENT
          Length = 926

 Score = 98.6 bits (244), Expect = 3e-19
 Identities = 53/125 (42%), Positives = 74/125 (59%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV F P Y+PHG  ++Y+   L L P  EEVAT +A  L TD++ K +F+ N
Sbjct: 382 KWTTLVHNGVMFLPPYKPHGVKMLYKXQPLTLTPEQEEVATMFAVMLDTDYMTKPRFKEN 441

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           FF+D++ +L        + +LE CDF  I    + EK K    +K  TT E+K  +E   
Sbjct: 442 FFSDWKKMLGKN---HTVQNLEDCDFGPIYEWHQQEKEK----RKQMTTEEKKALKE--- 491

Query: 528 ERVRQ 542
           ER++Q
Sbjct: 492 ERLQQ 496

[135][TOP]
>UniRef100_B4M707 GJ16891 n=1 Tax=Drosophila virilis RepID=B4M707_DROVI
          Length = 1045

 Score = 98.6 bits (244), Expect = 3e-19
 Identities = 53/130 (40%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   + DG VKWTTLEH G  F P YE  P      Y+G  L L    EE ATFYA
Sbjct: 485 WRWWEEEKREDG-VKWTTLEHKGPVFAPPYERMPRNVRFYYDGKPLELSEETEEAATFYA 543

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  K+ F +NFF DFR  +   K  ++I    KC+F  +      E  K+KA  
Sbjct: 544 KMLNHDYCTKDVFNNNFFKDFRKSMT-PKEKEIIKDFRKCNFQEMHQFFLAESEKRKAAT 602

Query: 480 KAQTTAERKE 509
           K +  A++ E
Sbjct: 603 KEEKLAKKNE 612

[136][TOP]
>UniRef100_B4JLU3 GH24453 n=1 Tax=Drosophila grimshawi RepID=B4JLU3_DROGR
          Length = 1063

 Score = 98.6 bits (244), Expect = 3e-19
 Identities = 52/130 (40%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   + DG VKWTTLEH G  F P YE  P      Y+G  L L    EE ATFYA
Sbjct: 503 WRWWEEKRRDDG-VKWTTLEHKGPVFAPPYERVPQNVRFFYDGKPLELSEETEEAATFYA 561

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  K+ F +NFF DFR  +   K  ++I    KC+F  +    + E  K+KA  
Sbjct: 562 KMLNHDYCTKDVFNTNFFKDFRKTMT-VKEKEIIKDFRKCNFQEMFQFFQAESEKRKAAT 620

Query: 480 KAQTTAERKE 509
           K +   ++ E
Sbjct: 621 KEEKLLKKNE 630

[137][TOP]
>UniRef100_Q8R4U6 DNA topoisomerase I, mitochondrial n=1 Tax=Mus musculus
           RepID=TOP1M_MOUSE
          Length = 593

 Score = 98.6 bits (244), Expect = 3e-19
 Identities = 57/138 (41%), Positives = 79/138 (57%), Gaps = 2/138 (1%)
 Frame = +3

Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308
           WE  +K+   VKW  LEH G YF P YEP   G   +Y+G  L L  AAEEVATFY   L
Sbjct: 36  WEETSKSS--VKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKML 93

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
             +   KE FR NFF+D+R  +   +  ++IT L+KCDF+ I  H       ++AE +  
Sbjct: 94  HLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHF-----LERAEARRT 147

Query: 489 TTAERKEAREAEAERVRQ 542
              E+K+  + EAE+++Q
Sbjct: 148 LPREQKQKLKEEAEKLQQ 165

[138][TOP]
>UniRef100_Q504F2 Top1l protein (Fragment) n=1 Tax=Danio rerio RepID=Q504F2_DANRE
          Length = 321

 Score = 98.2 bits (243), Expect = 3e-19
 Identities = 66/173 (38%), Positives = 91/173 (52%), Gaps = 2/173 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K E      K KT+D+    G  A      A+ E  +  ++WWE    TDG VKW  L
Sbjct: 159 KRKQEEEDIKPKKKTKDKK---GEVATDGKKKAKKEPEEK-WKWWEEERYTDG-VKWKFL 213

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP        Y+G  + L P AEEVATF++  L  ++  K+ FR NFF 
Sbjct: 214 EHKGPVFAPPYEPLPSNVKFYYDGKHMKLSPNAEEVATFFSKMLDHEYTTKDIFRKNFFK 273

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515
           D+R  +   + +K IT L KCDFS +  +    KA+ +A +KA T  E+K+ +
Sbjct: 274 DWRKEMTSEEKSK-ITDLNKCDFSNMSEYF---KAQSEA-RKAMTKEEKKKKK 321

[139][TOP]
>UniRef100_B5Y3I3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B5Y3I3_PHATR
          Length = 594

 Score = 98.2 bits (243), Expect = 3e-19
 Identities = 56/145 (38%), Positives = 79/145 (54%), Gaps = 5/145 (3%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYAS- 302
           F WW A    +G  +W T+EH+GV FP  YEPHG  ++Y+G  + L P  EE ATF+A+ 
Sbjct: 4   FLWWNAPELPEG-CQWRTMEHSGVSFPETYEPHGVKMMYDGQPVELTPIQEEAATFFAAM 62

Query: 303 KLQTDHVLKEK----FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK 470
             +  H+   K    F  NFFADFR +L       ++   +KCDF  I  HL ++    K
Sbjct: 63  DPEGMHLGNPKTGKIFIKNFFADFREILGK---KHIVKEFKKCDFEPIRKHLNEQ----K 115

Query: 471 AEKKAQTTAERKEAREAEAERVRQF 545
             +KA T  ERK  +E  ++ + QF
Sbjct: 116 IIRKAITDEERKANKEDRSQTLHQF 140

[140][TOP]
>UniRef100_UPI00016E5C65 UPI00016E5C65 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5C65
          Length = 755

 Score = 97.4 bits (241), Expect = 6e-19
 Identities = 65/187 (34%), Positives = 92/187 (49%), Gaps = 17/187 (9%)
 Frame = +3

Query: 36  KAKTEDRTLSPGRAAGSPLGAAEGENGDGG---------------FRWWEAGNKTDGEVK 170
           K KTE+   +  R     + A + +N  G                ++WWE    TDG VK
Sbjct: 148 KIKTENEKKAKKRKPDENIKAVKTKNKKGDVADGKKKAKKEQEEKWKWWEEERYTDG-VK 206

Query: 171 WTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344
           W  LEH G  F P YEP        Y+G    L   AEEVATF+A  L  ++  K+ FR 
Sbjct: 207 WKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFAKMLDHEYTTKDVFRK 266

Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
           NFF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +KA T  E+ + +E  
Sbjct: 267 NFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEEN 321

Query: 525 AERVRQF 545
              ++Q+
Sbjct: 322 ERLLQQY 328

[141][TOP]
>UniRef100_Q90WS1 Topoisomerase I beta n=1 Tax=Takifugu rubripes RepID=Q90WS1_TAKRU
          Length = 753

 Score = 97.4 bits (241), Expect = 6e-19
 Identities = 65/187 (34%), Positives = 92/187 (49%), Gaps = 17/187 (9%)
 Frame = +3

Query: 36  KAKTEDRTLSPGRAAGSPLGAAEGENGDGG---------------FRWWEAGNKTDGEVK 170
           K KTE+   +  R     + A + +N  G                ++WWE    TDG VK
Sbjct: 146 KIKTENEKKAKKRKPDENIKAVKTKNKKGDVADGKKKAKKEQEEKWKWWEEERYTDG-VK 204

Query: 171 WTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344
           W  LEH G  F P YEP        Y+G    L   AEEVATF+A  L  ++  K+ FR 
Sbjct: 205 WKFLEHKGPVFAPPYEPLPSNVKFYYDGKAFMLRAGAEEVATFFAKMLDHEYTTKDVFRK 264

Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
           NFF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +KA T  E+ + +E  
Sbjct: 265 NFFKDWRKEMTSEEKAK-ITDLKKCDFSEMHQYF---KAQSEA-RKAMTKEEKLKIKEEN 319

Query: 525 AERVRQF 545
              ++Q+
Sbjct: 320 ERLLQQY 326

[142][TOP]
>UniRef100_B7ZNM9 Top1mt protein n=1 Tax=Mus musculus RepID=B7ZNM9_MOUSE
          Length = 592

 Score = 97.4 bits (241), Expect = 6e-19
 Identities = 58/138 (42%), Positives = 80/138 (57%), Gaps = 2/138 (1%)
 Frame = +3

Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308
           WE  +K+   VKW  LEH G YF P YEP   G   +Y+G  L L  AAEEVATFY   L
Sbjct: 36  WEETSKSS--VKWRQLEHKGPYFTPAYEPLPDGVHFLYDGKPLKLSLAAEEVATFYGKML 93

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
             +   KE FR NFF+D+R  +   +  ++IT L+KCDF+ I  H       ++AE +  
Sbjct: 94  HLECTSKEVFRRNFFSDWRKEMTPEE-RRLITHLDKCDFTEIHKHF-----LERAEARRT 147

Query: 489 TTAERKEAREAEAERVRQ 542
              E+K+ +E EAE+++Q
Sbjct: 148 LPREQKQLKE-EAEKLQQ 164

[143][TOP]
>UniRef100_B4PWL3 GE17178 n=1 Tax=Drosophila yakuba RepID=B4PWL3_DROYA
          Length = 580

 Score = 97.4 bits (241), Expect = 6e-19
 Identities = 52/130 (40%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   + DG VKW+TLEH G  F P YE  P      Y+G  L L    EE ATFYA
Sbjct: 34  WRWWEEEKRADG-VKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYA 92

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  KE F +NFF DFR  +  +K  ++I    KC F  +    + E  K+KA  
Sbjct: 93  KMLNHDYCTKEVFNNNFFKDFRKSMT-SKEREIIKDFRKCGFQEMFNFFQAESEKRKAAT 151

Query: 480 KAQTTAERKE 509
           K +   ++ E
Sbjct: 152 KEEKLIKKNE 161

[144][TOP]
>UniRef100_UPI00017B3173 UPI00017B3173 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3173
          Length = 622

 Score = 97.1 bits (240), Expect = 8e-19
 Identities = 57/139 (41%), Positives = 75/139 (53%), Gaps = 6/139 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEE 281
           E     +RWWE     DG VKW  LEH+G YFPPEY+P        Y+G ++ L  AAEE
Sbjct: 47  EEEQSRWRWWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDHVNFYYDGKKVKLSLAAEE 105

Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLE 449
           VA F+A  L  ++  K+ FR NFF D+R  + D +   +I  L+KCDF  I    +A +E
Sbjct: 106 VALFFAQMLDHEYTTKKVFRENFFQDWRKEMTDEE-RSLIQELDKCDFGEIHAMHKAKVE 164

Query: 450 DEKAKKKAEKKAQTTAERK 506
             K   K EK     A +K
Sbjct: 165 ARKNMSKEEKLVLKEANQK 183

[145][TOP]
>UniRef100_UPI0000ECD01B topoisomerase (DNA) I, mitochondrial n=1 Tax=Gallus gallus
           RepID=UPI0000ECD01B
          Length = 593

 Score = 97.1 bits (240), Expect = 8e-19
 Identities = 56/145 (38%), Positives = 78/145 (53%), Gaps = 2/145 (1%)
 Frame = +3

Query: 114 GDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVA 287
           G GG   WE     DG VKW  LEH G YF P YEP        Y+G  L L  A EE+A
Sbjct: 27  GSGGCSRWEEEKTNDG-VKWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIA 85

Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK 467
           TFYA  L  ++  KE F++NFF D+R  +   +  ++I  L+KCDF  I  +  D+   +
Sbjct: 86  TFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEAR 144

Query: 468 KAEKKAQTTAERKEAREAEAERVRQ 542
           KA  K     E K+  + EA+++++
Sbjct: 145 KALSK-----EEKQKLKEEADKIQE 164

[146][TOP]
>UniRef100_Q6T722 Mitochondrial topoisomerase I n=1 Tax=Gallus gallus
           RepID=Q6T722_CHICK
          Length = 593

 Score = 97.1 bits (240), Expect = 8e-19
 Identities = 56/145 (38%), Positives = 78/145 (53%), Gaps = 2/145 (1%)
 Frame = +3

Query: 114 GDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVA 287
           G GG   WE     DG VKW  LEH G YF P YEP        Y+G  L L  A EE+A
Sbjct: 27  GSGGCSRWEEEKTNDG-VKWKQLEHKGPYFVPLYEPLPDDVQFYYDGKPLKLSLATEEIA 85

Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK 467
           TFYA  L  ++  KE F++NFF D+R  +   +  ++I  L+KCDF  I  +  D+   +
Sbjct: 86  TFYAKMLDHEYTTKEIFQNNFFNDWRKEMTPQE-QEIIKQLDKCDFREIHKYFVDKNEAR 144

Query: 468 KAEKKAQTTAERKEAREAEAERVRQ 542
           KA  K     E K+  + EA+++++
Sbjct: 145 KALSK-----EEKQKLKEEADKIQE 164

[147][TOP]
>UniRef100_UPI00017B27B1 UPI00017B27B1 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B1
          Length = 751

 Score = 96.7 bits (239), Expect = 1e-18
 Identities = 58/142 (40%), Positives = 80/142 (56%), Gaps = 2/142 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE    TDG VKW  LEH G  F P YEP        Y+G  + L   AEEVATF+A
Sbjct: 189 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 247

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +
Sbjct: 248 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-R 302

Query: 480 KAQTTAERKEAREAEAERVRQF 545
           KA T  E+ + +E     ++QF
Sbjct: 303 KAMTKEEKLKIKEENERILQQF 324

[148][TOP]
>UniRef100_UPI00017B27B0 UPI00017B27B0 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B27B0
          Length = 751

 Score = 96.7 bits (239), Expect = 1e-18
 Identities = 58/142 (40%), Positives = 80/142 (56%), Gaps = 2/142 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE    TDG VKW  LEH G  F P YEP        Y+G  + L   AEEVATF+A
Sbjct: 189 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 247

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +  +    KA+ +A +
Sbjct: 248 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYF---KAQTEA-R 302

Query: 480 KAQTTAERKEAREAEAERVRQF 545
           KA T  E+ + +E     ++QF
Sbjct: 303 KAMTKEEKLKIKEENERILQQF 324

[149][TOP]
>UniRef100_A7AUT4 DNA topoisomerase n=1 Tax=Babesia bovis RepID=A7AUT4_BABBO
          Length = 701

 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 53/144 (36%), Positives = 77/144 (53%), Gaps = 14/144 (9%)
 Frame = +3

Query: 129 RWWEAGNKTDGEVK-------------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPP 269
           RWWE   K D E               W  LEHNG+ F PEY+PHG P+ ++G  + L P
Sbjct: 92  RWWE---KVDNEFDLAKIMEYENQSCHWEYLEHNGMIFTPEYKPHGIPIKFKGEPITLTP 148

Query: 270 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK-FAKVITSLEKCDFSRIEAHL 446
             EEVATF+A  + T++   E +R NF+  F ++        K   +L+ CDFS I AHL
Sbjct: 149 DLEEVATFWAQSIGTNYEESEIYRRNFWNTFTSMFPKGHVIRKSKATLKDCDFSEIRAHL 208

Query: 447 EDEKAKKKAEKKAQTTAERKEARE 518
           + E+ KKK +K+     + + A++
Sbjct: 209 DMEREKKKEQKEYYKALKEETAKK 232

[150][TOP]
>UniRef100_UPI00016E5A48 UPI00016E5A48 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A48
          Length = 632

 Score = 95.9 bits (237), Expect = 2e-18
 Identities = 60/142 (42%), Positives = 80/142 (56%), Gaps = 3/142 (2%)
 Frame = +3

Query: 129 RW-WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           RW WE     DG VKW  LEH+G YFPPEY+P        Y+G ++ L  AAEEVA F+A
Sbjct: 69  RWRWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDNVHFYYDGKKVKLSLAAEEVALFFA 127

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  K+ FR NFF D+R  + D +   +I  L KCDF  I A     KAK +A +
Sbjct: 128 QMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHAM---HKAKVEA-R 182

Query: 480 KAQTTAERKEAREAEAERVRQF 545
           K  T  E++  +EA  + V +F
Sbjct: 183 KNMTKEEKQALKEANQKIVDEF 204

[151][TOP]
>UniRef100_Q7S0F7 DNA topoisomerase I n=1 Tax=Neurospora crassa RepID=Q7S0F7_NEUCR
          Length = 874

 Score = 95.1 bits (235), Expect = 3e-18
 Identities = 56/145 (38%), Positives = 79/145 (54%), Gaps = 11/145 (7%)
 Frame = +3

Query: 126 FRWWE-AGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFY 296
           ++WWE +  K D  +KWTTLEHNGV FP +Y+  P    L+Y+G  + L   AEE ATF+
Sbjct: 224 YKWWEESAKKEDDSIKWTTLEHNGVIFPEDYQRLPKDVKLLYDGTPVELDIEAEEAATFF 283

Query: 297 ASKL-QTDHVLKEKFRSNFFADFRALLADTKFAK-------VITSLEKCDFSRIEAHLED 452
              L  T +V    F+ NFF DF+ +L  T  AK        I   EK DFS++ A+ + 
Sbjct: 284 GFMLNSTVNVENPTFQKNFFRDFKEILDRTGGAKDKNGKKVDIKEFEKLDFSQLWAYKDA 343

Query: 453 EKAKKKAEKKAQTTAERKEAREAEA 527
           +   K A   A+  AE+ E  + +A
Sbjct: 344 QTKAKNARSSAEKKAEKAERDKRDA 368

[152][TOP]
>UniRef100_UPI0001792028 PREDICTED: similar to AGAP004078-PA n=1 Tax=Acyrthosiphon pisum
           RepID=UPI0001792028
          Length = 1011

 Score = 94.7 bits (234), Expect = 4e-18
 Identities = 61/164 (37%), Positives = 82/164 (50%), Gaps = 3/164 (1%)
 Frame = +3

Query: 36  KAKTEDRTLSP-GRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212
           K K E+ T        G+P    E E  +  ++WWE   K DG VKW  LEH G  F P 
Sbjct: 157 KVKKENNTSQKESPVKGTPKKKKEEEPQEV-WKWWEEEKKDDG-VKWKFLEHKGPVFAPA 214

Query: 213 YEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386
           YEP        Y G ++ L   AEEVATFYA  L+ D+  KE F  NF  D+R  +   K
Sbjct: 215 YEPLPSNVKFYYNGKQVVLSELAEEVATFYAKMLEHDYTTKEVFNKNFLKDWRKTMT-PK 273

Query: 387 FAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
             ++IT L  C+F  +  +      KK  E+KA +  E+K+ +E
Sbjct: 274 EKELITDLSLCNFKEMNVYF----TKKSEERKAMSKEEKKKIKE 313

[153][TOP]
>UniRef100_UPI00016E5F97 UPI00016E5F97 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F97
          Length = 790

 Score = 94.7 bits (234), Expect = 4e-18
 Identities = 63/185 (34%), Positives = 91/185 (49%), Gaps = 5/185 (2%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENG---DGGFRWWEAGNKTDGEVKW 173
           KVK E      K K E   + P +         EG+     +  ++WWE    TDG  KW
Sbjct: 200 KVKTEHDKKSKKRKHEYEDIKPKKKKKDK-NVTEGKKSKKDEEKWKWWEEERSTDGS-KW 257

Query: 174 TTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
             LEH G  F P YEP        Y+G  + L   AEEVATF+A  L  ++  K+ FR N
Sbjct: 258 RFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKN 317

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+  + + 
Sbjct: 318 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDN 371

Query: 528 ERVRQ 542
           ER+ Q
Sbjct: 372 ERILQ 376

[154][TOP]
>UniRef100_UPI0001B7BF13 similar to topoisomerase (DNA) I (LOC499179), mRNA n=1 Tax=Rattus
           norvegicus RepID=UPI0001B7BF13
          Length = 760

 Score = 94.0 bits (232), Expect = 7e-18
 Identities = 52/139 (37%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP   G    Y+G  + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLQEGVKFYYDGKVMKLSPKAEEVATFFA 261

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +      K ++E 
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 315

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 316 RKQMSKEEKLKIKEENEKL 334

[155][TOP]
>UniRef100_Q9WUL0 DNA topoisomerase 1 n=1 Tax=Rattus norvegicus RepID=TOP1_RAT
          Length = 767

 Score = 94.0 bits (232), Expect = 7e-18
 Identities = 52/139 (37%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP   G    Y+G  + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFA 263

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +      K ++E 
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 317

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 318 RKQMSKEEKLKIKEENEKL 336

[156][TOP]
>UniRef100_Q6IM78 DNA topoisomerase I, mitochondrial n=1 Tax=Rattus norvegicus
           RepID=TOP1M_RAT
          Length = 593

 Score = 94.0 bits (232), Expect = 7e-18
 Identities = 54/135 (40%), Positives = 74/135 (54%), Gaps = 2/135 (1%)
 Frame = +3

Query: 144 GNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTD 317
           G  +   VKW  LEH G  F P YEP   G    Y+G  + L  AAEEVATFY   L  +
Sbjct: 37  GETSKSSVKWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLE 96

Query: 318 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 497
              KE FR NFF+D++  +   +  K+IT L+KCDFS I  H       ++AE +     
Sbjct: 97  CTTKEVFRRNFFSDWQKEMT-AEERKLITHLDKCDFSEIHRHF-----MERAEARRTLPR 150

Query: 498 ERKEAREAEAERVRQ 542
           E+K+  + EAE+++Q
Sbjct: 151 EQKQKLKEEAEKLQQ 165

[157][TOP]
>UniRef100_UPI0001797824 PREDICTED: similar to topoisomerase I, partial n=1 Tax=Equus
           caballus RepID=UPI0001797824
          Length = 765

 Score = 93.6 bits (231), Expect = 9e-18
 Identities = 52/139 (37%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 261

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +ITSL KCDF+++  +      K + E 
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITSLSKCDFTQMSQYF-----KAQTEA 315

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 316 RKQMSKEEKLKIKEENEKL 334

[158][TOP]
>UniRef100_UPI00016E5F96 UPI00016E5F96 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F96
          Length = 767

 Score = 93.6 bits (231), Expect = 9e-18
 Identities = 57/171 (33%), Positives = 89/171 (52%), Gaps = 2/171 (1%)
 Frame = +3

Query: 36  KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEY 215
           K K +D+ ++ G+         + +  +  ++WWE    TDG  KW  LEH G  F P Y
Sbjct: 184 KKKKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPY 233

Query: 216 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 389
           EP        Y+G  + L   AEEVATF+A  L  ++  K+ FR NFF D+R  +   + 
Sbjct: 234 EPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEK 293

Query: 390 AKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
           +K IT L KC+F+ +     +E  K ++E + Q + E K+  + + ER+ Q
Sbjct: 294 SK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQKIKEDNERILQ 338

[159][TOP]
>UniRef100_O24307 Topoisomerase I n=1 Tax=Pisum sativum RepID=O24307_PEA
          Length = 892

 Score = 93.6 bits (231), Expect = 9e-18
 Identities = 50/127 (39%), Positives = 72/127 (56%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV FPP Y+PHG  ++Y G  + L P        YA    TD++ K++F+ N
Sbjct: 344 KWTTLVHNGVIFPPPYKPHGVKMLYMGRPVDLTPELRRGCYKYAVMRDTDYMQKDRFKEN 403

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           F+ D+R LL       VI +L+ CDF+ I    + EK K    KK  TT E+K  +E + 
Sbjct: 404 FWNDWRKLLGRN---HVIQNLKDCDFTPIYDWCQSEKEK----KKQMTTEEKKALKEEKL 456

Query: 528 ERVRQFT 548
           ++  ++T
Sbjct: 457 KQEEKYT 463

[160][TOP]
>UniRef100_C1MGX0 DNA topoisomerase I n=1 Tax=Micromonas pusilla CCMP1545
           RepID=C1MGX0_9CHLO
          Length = 685

 Score = 93.2 bits (230), Expect = 1e-17
 Identities = 48/122 (39%), Positives = 71/122 (58%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           +W TLEH+GV FPP YEP+  PL Y+G+++ L P  EE A F+A    TD+  K+ F  N
Sbjct: 163 QWKTLEHHGVVFPPPYEPNKVPLTYDGVDIVLLPHEEEAANFFAVMKDTDYAQKDVFVKN 222

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           F+  F+ +L     A  I   +KCDF+++      E+ KKKA    +   + K A++AE 
Sbjct: 223 FWEGFKKVLRGGPHAMTIKEFKKCDFTKMYMWHLKEREKKKAISN-EDKKKAKAAKDAEE 281

Query: 528 ER 533
           E+
Sbjct: 282 EK 283

[161][TOP]
>UniRef100_UPI00017EFDA4 PREDICTED: similar to DNA topoisomerase I, partial n=1 Tax=Sus
           scrofa RepID=UPI00017EFDA4
          Length = 748

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 187 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 245

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K ++E 
Sbjct: 246 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 299

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 300 RKQMSKEEKLKIKEENEKL 318

[162][TOP]
>UniRef100_UPI00006D45A8 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Macaca mulatta
           RepID=UPI00006D45A8
          Length = 767

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K ++E 
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 317

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 318 RKQMSKEEKLKIKEENEKL 336

[163][TOP]
>UniRef100_UPI00005A45B7 PREDICTED: similar to DNA topoisomerase I n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A45B7
          Length = 1004

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 442 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 500

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K ++E 
Sbjct: 501 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 554

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 555 RKQMSKEEKLKIKEENEKL 573

[164][TOP]
>UniRef100_UPI0000EB0F30 Topoisomerase I n=1 Tax=Canis lupus familiaris RepID=UPI0000EB0F30
          Length = 752

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 51/139 (36%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 190 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 248

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K ++E 
Sbjct: 249 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEA 302

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 303 RKQMSKEEKLKIKEENEKL 321

[165][TOP]
>UniRef100_Q90WS0 Topoisomerase I alpha n=1 Tax=Takifugu rubripes RepID=Q90WS0_TAKRU
          Length = 767

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 56/171 (32%), Positives = 88/171 (51%), Gaps = 2/171 (1%)
 Frame = +3

Query: 36  KAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEY 215
           K K +D+ ++ G+         + +  +  ++WWE    TDG  KW  LEH G  F P Y
Sbjct: 184 KKKKKDKNVTEGK---------KSKKDEEKWKWWEEERSTDGS-KWRFLEHKGPVFAPPY 233

Query: 216 EP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKF 389
           EP        Y+G  + L   AEEVATF+A  L  ++  K+ FR NFF D+R  +   + 
Sbjct: 234 EPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEK 293

Query: 390 AKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
           +K IT L KC+F+ +  +      K ++E + Q + E K+  + + ER+ Q
Sbjct: 294 SK-ITDLNKCNFAGMNDYF-----KAQSEARKQMSKEEKQKIKEDNERILQ 338

[166][TOP]
>UniRef100_Q4SR65 Chromosome 11 SCAF14528, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SR65_TETNG
          Length = 806

 Score = 92.8 bits (229), Expect = 1e-17
 Identities = 55/124 (44%), Positives = 69/124 (55%), Gaps = 6/124 (4%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE    TDG VKW  LEH G  F P YEP        Y+G  + L   AEEVATF+A
Sbjct: 171 WKWWEEERYTDG-VKWKFLEHKGPVFAPPYEPLPSNVRFYYDGKPMVLSADAEEVATFFA 229

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI----EAHLEDEKAKK 467
             L  ++  K+ FR NFF D+R  +   + AK IT L+KCDFS +    +A  E  KA  
Sbjct: 230 KMLDHEYTTKDVFRKNFFKDWRKEMTPEEKAK-ITDLKKCDFSEMHQYFKAQTEARKAMT 288

Query: 468 KAEK 479
           K EK
Sbjct: 289 KEEK 292

[167][TOP]
>UniRef100_UPI000194D872 PREDICTED: topoisomerase (DNA) I n=1 Tax=Taeniopygia guttata
           RepID=UPI000194D872
          Length = 775

 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 59/180 (32%), Positives = 87/180 (48%), Gaps = 2/180 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K + E      K K++D+ +        P    E +     ++WWE     +G +KW  L
Sbjct: 177 KQEEEEDSKAKKIKSKDKKVPEADKRKKPKKEEEQK-----WKWWEEERYPEG-IKWKFL 230

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP        Y+G  + L   AEEVATF+A  L  ++  KE FR NFF 
Sbjct: 231 EHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFK 290

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536
           D+R  +   +    ITSL KCDF+ +  +      K ++E + Q + E K+  + E ER+
Sbjct: 291 DWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQSEARKQMSKEEKQKIKEENERL 344

[168][TOP]
>UniRef100_UPI00006154BF PREDICTED: topoisomerase (DNA) I n=1 Tax=Bos taurus
           RepID=UPI00006154BF
          Length = 769

 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 207 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 265

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K + E 
Sbjct: 266 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 319

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 320 RKQMSKEEKLKIKEENEKL 338

[169][TOP]
>UniRef100_P79994 DNA topoisomerase I n=2 Tax=Gallus gallus RepID=P79994_CHICK
          Length = 766

 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 60/180 (33%), Positives = 85/180 (47%), Gaps = 2/180 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K + E      KAK +D+          P    E +     ++WWE     +G +KW  L
Sbjct: 168 KQEEEEDSKAKKAKNKDKKSPEADKRKKPKKEEEQK-----WKWWEEERYPEG-IKWKFL 221

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP        Y+G  + L   AEEVATF+A  L  ++  KE FR NFF 
Sbjct: 222 EHKGPVFAPPYEPLPENVKFYYDGKVMKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFK 281

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERV 536
           D+R  +   +    ITSL KCDF+ +  +      K + E + Q + E K+  + E ER+
Sbjct: 282 DWRKEMTSEE-KSTITSLSKCDFTHMSQYF-----KAQTEARKQMSKEEKQKIKEENERL 335

[170][TOP]
>UniRef100_B9EG90 Topoisomerase (DNA) I n=1 Tax=Homo sapiens RepID=B9EG90_HUMAN
          Length = 765

 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 261

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K + E 
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 315

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 316 RKQMSKEEKLKIKEENEKL 334

[171][TOP]
>UniRef100_P11387 DNA topoisomerase 1 n=1 Tax=Homo sapiens RepID=TOP1_HUMAN
          Length = 765

 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 203 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 261

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K + E 
Sbjct: 262 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 315

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 316 RKQMSKEEKLKIKEENEKL 334

[172][TOP]
>UniRef100_UPI0000F2B3E5 PREDICTED: similar to topoisomerase I n=1 Tax=Monodelphis domestica
           RepID=UPI0000F2B3E5
          Length = 916

 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 52/139 (37%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 354 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 412

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  K+ FR NFF D+R  + + +    IT+L KCDF++I  +      K ++E 
Sbjct: 413 KMLDHEYTTKDIFRKNFFKDWRKEMTNEE-KNSITNLSKCDFNQISQYF-----KAQSEA 466

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E ER+
Sbjct: 467 RKQMSKEEKLKIKEENERL 485

[173][TOP]
>UniRef100_Q7YR26 DNA topoisomerase 1 n=1 Tax=Chlorocebus aethiops RepID=TOP1_CERAE
          Length = 767

 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPDSVKFYYDGKVMKLSPKAEEVATFFA 263

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K + E 
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQTEA 317

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 318 RKQMSKEEKLKIKEENEKL 336

[174][TOP]
>UniRef100_UPI00015DF5D0 topoisomerase (DNA) I n=1 Tax=Mus musculus RepID=UPI00015DF5D0
          Length = 758

 Score = 91.7 bits (226), Expect = 3e-17
 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 196 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 254

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +      K ++E 
Sbjct: 255 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 308

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 309 RKQMSKEEKLKIKEENEKL 327

[175][TOP]
>UniRef100_UPI00016E5A49 UPI00016E5A49 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5A49
          Length = 692

 Score = 91.7 bits (226), Expect = 3e-17
 Identities = 55/130 (42%), Positives = 70/130 (53%), Gaps = 3/130 (2%)
 Frame = +3

Query: 129 RW-WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           RW WE     DG VKW  LEH+G YFPPEY+P        Y+G ++ L  AAEEVA F+A
Sbjct: 68  RWRWEEEKYEDG-VKWRFLEHSGPYFPPEYQPLPDNVHFYYDGKKVKLSLAAEEVALFFA 126

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  K+ FR NFF D+R  + D +   +I  L KCDF  I A       K K E 
Sbjct: 127 QMLDHEYTTKKVFRENFFKDWRKEMTDAE-RSLIQDLGKCDFGEIHA-----MHKAKVEA 180

Query: 480 KAQTTAERKE 509
           +   T E K+
Sbjct: 181 RKNMTKEEKQ 190

[176][TOP]
>UniRef100_Q4N5U3 DNA topoisomerase I, putative n=1 Tax=Theileria parva
           RepID=Q4N5U3_THEPA
          Length = 1003

 Score = 91.7 bits (226), Expect = 3e-17
 Identities = 50/142 (35%), Positives = 75/142 (52%), Gaps = 13/142 (9%)
 Frame = +3

Query: 129 RWWEAGNKTDGEV-------------KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPP 269
           RWWE   + DG++             +W  LEHNG+ F PEY PH  P+  +G  +HLPP
Sbjct: 313 RWWE---EIDGDMDYNKGLEFESKSSRWKYLEHNGMIFTPEYVPHNVPIKVKGETIHLPP 369

Query: 270 AAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLE 449
             EE+AT +A  + T++   + +  NF+  F +      F +    L   DFS I+ HLE
Sbjct: 370 HLEEIATMWAQSIGTNYETSDIYCKNFWQVFVSKFEKDHFIR-RCKLTDVDFSLIKTHLE 428

Query: 450 DEKAKKKAEKKAQTTAERKEAR 515
           DEK KKK  K+     ++++A+
Sbjct: 429 DEKQKKKDNKEFYKAKQQEDAK 450

[177][TOP]
>UniRef100_Q04750 DNA topoisomerase 1 n=1 Tax=Mus musculus RepID=TOP1_MOUSE
          Length = 767

 Score = 91.7 bits (226), Expect = 3e-17
 Identities = 51/139 (36%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  KE FR NFF D+R  + + +    IT+L KCDF+++  +      K ++E 
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWRKEMTNDE-KNTITNLSKCDFTQMSQYF-----KAQSEA 317

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K   + E E++
Sbjct: 318 RKQMSKEEKLKIKEENEKL 336

[178][TOP]
>UniRef100_UPI000155C8C4 PREDICTED: similar to topoisomerase I n=1 Tax=Ornithorhynchus
           anatinus RepID=UPI000155C8C4
          Length = 781

 Score = 91.3 bits (225), Expect = 4e-17
 Identities = 50/139 (35%), Positives = 77/139 (55%), Gaps = 2/139 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 219 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFA 277

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  ++  K+ FR NFF D+R  + + + +  IT+L KCDF+ +  +      K ++E 
Sbjct: 278 KMLDHEYTTKDIFRKNFFKDWRKEMTNEEKSN-ITNLSKCDFNHMSQYF-----KAQSEA 331

Query: 480 KAQTTAERKEAREAEAERV 536
           + Q + E K+  + E E++
Sbjct: 332 RKQMSKEEKQKIKEENEQL 350

[179][TOP]
>UniRef100_P93119 DNA topoisomerase 1 n=1 Tax=Daucus carota RepID=TOP1_DAUCA
          Length = 790

 Score = 91.3 bits (225), Expect = 4e-17
 Identities = 49/117 (41%), Positives = 70/117 (59%)
 Frame = +3

Query: 180 LEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFAD 359
           L HNGV FPP Y+PHG  ++Y    + L P  EEVAT +A  L+T+++ K KFR NF +D
Sbjct: 220 LVHNGVIFPPLYKPHGVKMLYRENPVDLTPEQEEVATMFAVMLETEYMTKPKFRENFMSD 279

Query: 360 FRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
           +R +L +     +I +LE CDF+ I    + EK K    KK  +T E+K  +E + E
Sbjct: 280 WRKILGE---KHIIQNLEDCDFTPIYEWHQREKEK----KKQMSTDEKKAIKEGKDE 329

[180][TOP]
>UniRef100_UPI00017B1DB6 UPI00017B1DB6 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1DB6
          Length = 770

 Score = 90.9 bits (224), Expect = 6e-17
 Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%)
 Frame = +3

Query: 42  KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 221
           K +D+ ++ G+         + +  +  ++WWE    TDG  KW  L H G  F P YEP
Sbjct: 189 KKKDKNVTEGK---------KSKKDEEKWKWWEEERYTDGS-KWRFLGHKGPVFAPPYEP 238

Query: 222 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395
                   Y+G  + L   AEEVATF+A  L  ++  K+ FR NFF D+R  +   + +K
Sbjct: 239 LPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 298

Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
            IT L KC+F+ +     +E  K ++E + Q + E K+  + E ER+ Q
Sbjct: 299 -ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEENERILQ 341

[181][TOP]
>UniRef100_Q4T6N6 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N6_TETNG
          Length = 783

 Score = 90.9 bits (224), Expect = 6e-17
 Identities = 56/169 (33%), Positives = 87/169 (51%), Gaps = 2/169 (1%)
 Frame = +3

Query: 42  KTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP 221
           K +D+ ++ G+         + +  +  ++WWE    TDG  KW  L H G  F P YEP
Sbjct: 170 KKKDKNVTEGK---------KSKKDEEKWKWWEEERYTDGS-KWRFLGHKGPVFAPPYEP 219

Query: 222 --HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK 395
                   Y+G  + L   AEEVATF+A  L  ++  K+ FR NFF D+R  +   + +K
Sbjct: 220 LPDKVKFYYDGKPMKLGAPAEEVATFFAKMLDHEYTTKDVFRKNFFKDWRKEMTSEEKSK 279

Query: 396 VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQ 542
            IT L KC+F+ +     +E  K ++E + Q + E K+  + E ER+ Q
Sbjct: 280 -ITDLNKCNFTEM-----NEYFKAQSEARKQMSKEEKQKIKEENERILQ 322

[182][TOP]
>UniRef100_Q4UDP8 DNA topoisomerase i, putative n=1 Tax=Theileria annulata
           RepID=Q4UDP8_THEAN
          Length = 999

 Score = 90.9 bits (224), Expect = 6e-17
 Identities = 48/139 (34%), Positives = 73/139 (52%), Gaps = 10/139 (7%)
 Frame = +3

Query: 129 RWWEAGNKT----------DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           RWWE  ++               +W  LEHNG+ F PEY PH  P++ +G  +HLPP  E
Sbjct: 314 RWWEEIDEDMDYNKGLEFESKSSRWKYLEHNGMIFTPEYVPHNIPIMVKGETIHLPPNLE 373

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEK 458
           E+AT +A  + T++   E +  NF+  F +      F +    L   DFS I+ HLE+EK
Sbjct: 374 EIATMWAQSMGTNYETSEIYCKNFWQVFVSKFEKDHFIR-RCKLSDADFSLIKNHLEEEK 432

Query: 459 AKKKAEKKAQTTAERKEAR 515
            KKK  K+     ++++A+
Sbjct: 433 QKKKDNKEFYKAKQQEDAK 451

[183][TOP]
>UniRef100_UPI0001A2C88D UPI0001A2C88D related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C88D
          Length = 609

 Score = 90.5 bits (223), Expect = 7e-17
 Identities = 61/175 (34%), Positives = 89/175 (50%), Gaps = 3/175 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K + ER V+  K KT++       AA +     + E     +RWWE   K +  +KW  L
Sbjct: 10  KEEGERPVSTKKKKTKEEI----EAARALKIKKKEEEEKQRWRWWEE-EKYENGIKWKFL 64

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G YFPP Y+P        Y G  + L   AEEVA ++A  L  ++  KE FR+NFF 
Sbjct: 65  EHKGPYFPPAYQPLPDDVKFYYNGEPVKLSLPAEEVALYFAQMLDHEYTTKEVFRNNFFK 124

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEA-HLEDEKAKKKAEKKAQTTAERKEARE 518
           D+R  +   +  ++I  L+KCDF  + A H E  +A+K   K+ +     KEA +
Sbjct: 125 DWRKEMT-LEERQLIMDLKKCDFGELHAMHKEKVEARKNLSKEEKLV--NKEANQ 176

[184][TOP]
>UniRef100_UPI00016E5F98 UPI00016E5F98 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5F98
          Length = 790

 Score = 90.5 bits (223), Expect = 7e-17
 Identities = 60/174 (34%), Positives = 86/174 (49%), Gaps = 5/174 (2%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENG---DGGFRWWEAGNKTDGEVKW 173
           KVK E      K K E + + P +         EG+     +  ++WWE    TDG  KW
Sbjct: 135 KVKTEHDKKSKKRKHEFQDIKPKKKKKDK-NVTEGKKSKKDEEKWKWWEEERSTDGS-KW 192

Query: 174 TTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
             LEH G  F P YEP        Y+G  + L   AEEVATF+A  L  ++  K+ FR N
Sbjct: 193 RFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKMLDHEYTTKDVFRKN 252

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           FF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q + E K+
Sbjct: 253 FFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQMSKEEKQ 300

[185][TOP]
>UniRef100_Q7QH57 AGAP004078-PA n=1 Tax=Anopheles gambiae RepID=Q7QH57_ANOGA
          Length = 969

 Score = 90.1 bits (222), Expect = 9e-17
 Identities = 52/137 (37%), Positives = 73/137 (53%), Gaps = 6/137 (4%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE   + DG VKW  LEH G  F P Y+P       +Y+G E+ L   AEEVA FYA
Sbjct: 428 WKWWEEEKRDDG-VKWKYLEHKGPVFAPPYDPLPSHVKFMYDGKEMKLSQDAEEVAGFYA 486

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL----EDEKAKK 467
             L+ D+  K+ F  NFF D+R  +   +  + IT LEKC+F  + A+     E  + + 
Sbjct: 487 RMLEHDYTSKQAFNDNFFKDWRKTMTPHERER-ITDLEKCNFRPMAAYFAEIAEQNRNRS 545

Query: 468 KAEKKAQTTAERKEARE 518
           K EK A   A  +  +E
Sbjct: 546 KEEKAALKAANEQLTKE 562

[186][TOP]
>UniRef100_B9Q6S5 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii VEG
           RepID=B9Q6S5_TOXGO
          Length = 953

 Score = 90.1 bits (222), Expect = 9e-17
 Identities = 53/148 (35%), Positives = 76/148 (51%), Gaps = 21/148 (14%)
 Frame = +3

Query: 108 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           EN +   RWWE   A  + + E +W+ LEHNG+ F P YEPHG  L Y G  + LPP AE
Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQLTYHGKPVSLPPEAE 343

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 413
           EVA ++   L++D+  K +F  NF+  F         +L +  FA+   + E        
Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403

Query: 414 ---KCDFSRIEAHLEDEKAKKKAEKKAQ 488
               CDFS I+ +L+ +K  KK   K +
Sbjct: 404 GFAACDFSPIKEYLDKQKELKKEMSKEE 431

[187][TOP]
>UniRef100_Q28GG2 Novel protein similar to topoisomerase (DNA) I top1 (Fragment) n=1
           Tax=Xenopus (Silurana) tropicalis RepID=Q28GG2_XENTR
          Length = 335

 Score = 89.4 bits (220), Expect = 2e-16
 Identities = 56/155 (36%), Positives = 79/155 (50%), Gaps = 6/155 (3%)
 Frame = +3

Query: 33  GKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212
           G  K + +T     AA +     + E     +RWWE     DG +KW  LEH G  F P 
Sbjct: 182 GAIKAKKKTQEEKEAAAALKLKKKEEEEQMRWRWWEEEKYEDG-IKWKFLEHEGPVFAPP 240

Query: 213 YEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386
           YEP        Y+G  L L   AEEVA+F+A  L  ++  KE FR+N+F D+R  +   +
Sbjct: 241 YEPLPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LE 299

Query: 387 FAKVITSLEKCDFSRI----EAHLEDEKAKKKAEK 479
              VIT L KCDF+ +    +  +E++K K K +K
Sbjct: 300 ERMVITDLAKCDFTEMFTYYKGKMEEKKNKSKEDK 334

[188][TOP]
>UniRef100_Q0V9D3 Putative uncharacterized protein (Fragment) n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=Q0V9D3_XENTR
          Length = 495

 Score = 89.4 bits (220), Expect = 2e-16
 Identities = 56/155 (36%), Positives = 79/155 (50%), Gaps = 6/155 (3%)
 Frame = +3

Query: 33  GKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212
           G  K + +T     AA +     + E     +RWWE     DG +KW  LEH G  F P 
Sbjct: 88  GAIKAKKKTQEEKEAAAALKLKKKEEEEQMRWRWWEEEKYEDG-IKWKFLEHEGPVFAPP 146

Query: 213 YEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386
           YEP        Y+G  L L   AEEVA+F+A  L  ++  KE FR+N+F D+R  +   +
Sbjct: 147 YEPLPDSVKFYYDGKPLPLSLQAEEVASFFAKMLDHEYTTKEIFRNNYFMDWRKEMT-LE 205

Query: 387 FAKVITSLEKCDFSRI----EAHLEDEKAKKKAEK 479
              VIT L KCDF+ +    +  +E++K K K +K
Sbjct: 206 ERMVITDLAKCDFTEMFTYYKGKMEEKKNKSKEDK 240

[189][TOP]
>UniRef100_B9PWF4 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii GT1
           RepID=B9PWF4_TOXGO
          Length = 953

 Score = 89.4 bits (220), Expect = 2e-16
 Identities = 52/148 (35%), Positives = 76/148 (51%), Gaps = 21/148 (14%)
 Frame = +3

Query: 108 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           EN +   RWWE   A  + + E +W+ LEHNG+ F P YEPHG  + Y G  + LPP AE
Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAE 343

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 413
           EVA ++   L++D+  K +F  NF+  F         +L +  FA+   + E        
Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403

Query: 414 ---KCDFSRIEAHLEDEKAKKKAEKKAQ 488
               CDFS I+ +L+ +K  KK   K +
Sbjct: 404 GFAACDFSPIKEYLDKQKELKKEMSKEE 431

[190][TOP]
>UniRef100_B6KM03 DNA topoisomerase I, putative n=1 Tax=Toxoplasma gondii ME49
           RepID=B6KM03_TOXGO
          Length = 953

 Score = 89.4 bits (220), Expect = 2e-16
 Identities = 52/148 (35%), Positives = 76/148 (51%), Gaps = 21/148 (14%)
 Frame = +3

Query: 108 ENGDGGFRWWE---AGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAE 278
           EN +   RWWE   A  + + E +W+ LEHNG+ F P YEPHG  + Y G  + LPP AE
Sbjct: 284 ENFEPINRWWERTEAEIEREQEKQWSYLEHNGLMFAPPYEPHGKQITYHGKPVSLPPEAE 343

Query: 279 EVATFYASKLQTDHVLKEKFRSNFFADF-------RALLADTKFAKVITSLE-------- 413
           EVA ++   L++D+  K +F  NF+  F         +L +  FA+   + E        
Sbjct: 344 EVANYWCGVLESDYATKPRFVENFWKAFLRNLPKDHPILVEEGFAEAKLATEYKEGERMV 403

Query: 414 ---KCDFSRIEAHLEDEKAKKKAEKKAQ 488
               CDFS I+ +L+ +K  KK   K +
Sbjct: 404 GFAACDFSPIKEYLDKQKELKKEMSKEE 431

[191][TOP]
>UniRef100_A8XXL4 C. briggsae CBR-TOP-1 protein n=1 Tax=Caenorhabditis briggsae AF16
           RepID=A8XXL4_CAEBR
          Length = 840

 Score = 88.6 bits (218), Expect = 3e-16
 Identities = 58/181 (32%), Positives = 91/181 (50%), Gaps = 3/181 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRA-AGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179
           K K +++      K +  T +P +     P      E  +  + WW+   K DG VKW T
Sbjct: 222 KKKKKKKKKAKAEKNKPSTSTPAKNNKKEPSKKKVKEEQEEIWEWWKEEKKPDG-VKWNT 280

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           L+H G  F P Y P        Y G  + L PAAEE ATFYA  +  ++  + +F +NF 
Sbjct: 281 LQHCGPLFAPAYIPLPDHVHFKYNGHRMKLSPAAEECATFYAGVVNHEYSSQVQFNTNFM 340

Query: 354 ADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533
            D+R L+   +  K IT L KCDF+    H+ + + +++  +KA T  E+ + +E +A+ 
Sbjct: 341 KDWRKLMTSGEREK-ITDLAKCDFT----HIVEYQNEQREIRKAMTKEEKAKIKEEKAQE 395

Query: 534 V 536
           V
Sbjct: 396 V 396

[192][TOP]
>UniRef100_Q5CY81 Eukaryotic DNA topoisomerase I (Fragment) n=1 Tax=Cryptosporidium
           parvum Iowa II RepID=Q5CY81_CRYPV
          Length = 653

 Score = 88.2 bits (217), Expect = 4e-16
 Identities = 45/126 (35%), Positives = 65/126 (51%)
 Frame = +3

Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           +WWE   K +  ++W  LEH GV F P Y+ H  PL Y G  + LPP AEE+A++++   
Sbjct: 43  KWWERPPKEELGIQWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMK 102

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
            T+   KEKF +N    F   +            EKC+F  I+ + EDEK  KK   K +
Sbjct: 103 DTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEE 162

Query: 489 TTAERK 506
              ++K
Sbjct: 163 KELQKK 168

[193][TOP]
>UniRef100_Q5CN58 DNA topoisomerase I n=1 Tax=Cryptosporidium hominis
           RepID=Q5CN58_CRYHO
          Length = 641

 Score = 88.2 bits (217), Expect = 4e-16
 Identities = 45/126 (35%), Positives = 65/126 (51%)
 Frame = +3

Query: 129 RWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           +WWE   K +  ++W  LEH GV F P Y+ H  PL Y G  + LPP AEE+A++++   
Sbjct: 31  KWWERPPKEELGIQWEYLEHQGVMFAPPYKVHNVPLEYNGERIQLPPEAEEIASYWSVMK 90

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
            T+   KEKF +N    F   +            EKC+F  I+ + EDEK  KK   K +
Sbjct: 91  DTEWAQKEKFSNNVRKAFMNSIPVGDKLHNNLEWEKCNFDIIKQYFEDEKEAKKNLSKEE 150

Query: 489 TTAERK 506
              ++K
Sbjct: 151 KELQKK 156

[194][TOP]
>UniRef100_A8Q2Z1 DNA topoisomerase I, putative n=1 Tax=Brugia malayi
           RepID=A8Q2Z1_BRUMA
          Length = 751

 Score = 87.8 bits (216), Expect = 5e-16
 Identities = 49/142 (34%), Positives = 75/142 (52%), Gaps = 6/142 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEE 281
           E+ +  ++WWE   K  G +KW +L H G  F P Y   P      Y+G  + L P  EE
Sbjct: 193 EDEEEVWKWWEEEKKPSG-IKWYSLSHKGPIFAPPYVSLPESIHFKYDGKVMKLAPLTEE 251

Query: 282 VATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL----E 449
           VA+FYA  L+ ++  K+ F  NFF D+R ++   +  K IT L KCDF  +  H     E
Sbjct: 252 VASFYAKILEHEYTTKDIFNKNFFTDWRKVMTPAEREK-ITDLTKCDFREMHDHYIKLRE 310

Query: 450 DEKAKKKAEKKAQTTAERKEAR 515
           + ++  K EK+     +++EA+
Sbjct: 311 ERRSLSKEEKQKLKEIKQEEAK 332

[195][TOP]
>UniRef100_Q5IFJ5 TOP1 (Fragment) n=1 Tax=Macaca fascicularis RepID=Q5IFJ5_MACFA
          Length = 560

 Score = 87.4 bits (215), Expect = 6e-16
 Identities = 50/136 (36%), Positives = 74/136 (54%), Gaps = 2/136 (1%)
 Frame = +3

Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308
           WE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A  L
Sbjct: 1   WEEERYPEG-IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML 59

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
             ++  KE FR NFF D+R  + + +   +IT+L KCDF+++  +      K ++E + Q
Sbjct: 60  DHEYTTKEIFRKNFFKDWRKEMTNEE-KNIITNLSKCDFTQMSQYF-----KAQSEARKQ 113

Query: 489 TTAERKEAREAEAERV 536
            + E K   + E E++
Sbjct: 114 MSKEEKLKIKEENEKL 129

[196][TOP]
>UniRef100_Q5C1T3 SJCHGC05060 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5C1T3_SCHJA
          Length = 330

 Score = 87.0 bits (214), Expect = 8e-16
 Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 3/164 (1%)
 Frame = +3

Query: 36  KAKTEDRTLSPGRAAGSPL-GAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPE 212
           +++T    +    A  SP  G  + +  +  +RWWE   K DG VKW  LEH G  F P 
Sbjct: 85  RSRTTHEKIKKQNALSSPTKGRKQEKPEEEVWRWWEEQKKDDG-VKWKFLEHKGPLFAPP 143

Query: 213 YE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTK 386
           YE  P      Y+   + L   AEEVA FYA  L  D+  KE F  NFF D+   + + +
Sbjct: 144 YERLPSSVHFHYDSKPMKLSDHAEEVAGFYARMLDHDYTTKEVFNHNFFHDWVKTMNEEE 203

Query: 387 FAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEARE 518
             + I SL KCDF  +  +      K   E+K +T  E+++ +E
Sbjct: 204 -RRTIKSLSKCDFQEMHQYF----LKLSEERKNRTKEEKQKIKE 242

[197][TOP]
>UniRef100_Q17HT9 DNA topoisomerase type I n=1 Tax=Aedes aegypti RepID=Q17HT9_AEDAE
          Length = 966

 Score = 87.0 bits (214), Expect = 8e-16
 Identities = 56/172 (32%), Positives = 82/172 (47%), Gaps = 2/172 (1%)
 Frame = +3

Query: 12  AERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHN 191
           A ++    K   ++ T SP +         + E  +  ++WWE   + DG VKW TLEH 
Sbjct: 377 AAKKKKQAKQVKKEETASPTKGRKK-----KQEEEEEVWKWWEEEKREDG-VKWNTLEHK 430

Query: 192 GVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFR 365
           G  F P YEP        Y+G  + L   AEE+A FYA  L+ ++  K+ F  NFF D+R
Sbjct: 431 GPVFAPPYEPLPDNVKFEYDGKVIKLSQDAEEIAGFYARMLEHEYTSKDAFNDNFFKDWR 490

Query: 366 ALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521
             +  ++  K I  L+KC+F  +  H  +     +   K Q  A  KE  EA
Sbjct: 491 KSMTSSEREK-IKDLKKCNFRSMHKHFAEISEANRNRTKEQKLA-LKEQNEA 540

[198][TOP]
>UniRef100_UPI00016E5FAF UPI00016E5FAF related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E5FAF
          Length = 573

 Score = 86.3 bits (212), Expect = 1e-15
 Identities = 52/138 (37%), Positives = 74/138 (53%), Gaps = 2/138 (1%)
 Frame = +3

Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKL 308
           WE    TDG  KW  LEH G  F P YEP        Y+G  + L   AEEVATF+A  L
Sbjct: 14  WEEERSTDGS-KWRFLEHKGPVFAPPYEPLPDKVKFYYDGKLMKLAAPAEEVATFFAKML 72

Query: 309 QTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
             ++  K+ FR NFF D+R  +   + +K IT L KC+F+ +     +E  K ++E + Q
Sbjct: 73  DHEYTTKDVFRKNFFKDWRKEMTSEEKSK-ITDLNKCNFAGM-----NEYFKAQSEARKQ 126

Query: 489 TTAERKEAREAEAERVRQ 542
            + E K+  + + ER+ Q
Sbjct: 127 MSKEEKQKIKEDNERILQ 144

[199][TOP]
>UniRef100_B0WA62 Putative uncharacterized protein n=1 Tax=Culex quinquefasciatus
           RepID=B0WA62_CULQU
          Length = 962

 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 58/175 (33%), Positives = 86/175 (49%), Gaps = 6/175 (3%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTE--DRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179
           VK E +    K KTE    T SP +         E E     ++WWE   + DG VKW  
Sbjct: 370 VKKENKT---KVKTEVKQETASPTKGGRKKKQEEEQEV----WKWWEEEKREDG-VKWNF 421

Query: 180 LEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFF 353
           LEH G  F P Y+P        Y+G  + L    EEVA FYA  ++ ++  K+ F  NFF
Sbjct: 422 LEHKGPVFAPPYDPLPENVKFEYDGKVMKLSQDTEEVAGFYARMIEHEYTSKDVFNDNFF 481

Query: 354 ADFRALLADTKFAKVITSLEKCDFSRIEAHLED--EKAKKKAEKKAQTTAERKEA 512
            D+R  +  ++  K I  L+KC+F  + A+  D  EK + +++++     E+ EA
Sbjct: 482 KDWRKTMTSSEREK-IKDLKKCNFKYMHAYFTDLSEKNRNRSKEEKLALKEQNEA 535

[200][TOP]
>UniRef100_UPI000179DDCD DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)
           (TOP1mt). n=1 Tax=Bos taurus RepID=UPI000179DDCD
          Length = 620

 Score = 85.1 bits (209), Expect = 3e-15
 Identities = 53/135 (39%), Positives = 78/135 (57%), Gaps = 4/135 (2%)
 Frame = +3

Query: 150 KTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEG--MELHLPPAAEEVATFYASKLQTD 317
           K+ G VKWT LEH G +F   YE  P G P   +   + + L  AAEEVATFY  KL  +
Sbjct: 1   KSPGGVKWTQLEHRGPWFAAPYEPLPEGVPSTTDRLLLTIKLILAAEEVATFYGKKLDRE 60

Query: 318 HVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTA 497
           +  KE F++NFF+D+R  +   +  +VI  L++CDF+ I  H  D+ A +KA      + 
Sbjct: 61  YT-KEVFQNNFFSDWRKEMT-AEEGRVIKHLDRCDFTEIHRHSVDKTASQKA-----LSR 113

Query: 498 ERKEAREAEAERVRQ 542
           E K+  + E E+++Q
Sbjct: 114 EEKQKLKEEEEKLQQ 128

[201][TOP]
>UniRef100_C4Q6C8 DNA topoisomerase type I, putative n=2 Tax=Schistosoma mansoni
           RepID=C4Q6C8_SCHMA
          Length = 587

 Score = 84.7 bits (208), Expect = 4e-15
 Identities = 51/133 (38%), Positives = 68/133 (51%), Gaps = 2/133 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG VKW  LEH G  F P YE  P      Y+   + L   AEEVA FYA
Sbjct: 124 WRWWEEQKKDDG-VKWKFLEHKGPLFAPPYERLPSSVHFHYDSKPIKLSDHAEEVAGFYA 182

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  KE F  NFF D+   + + +  + I SL KCDF  +  +      K   E+
Sbjct: 183 RMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEER 237

Query: 480 KAQTTAERKEARE 518
           K +T  E+++ +E
Sbjct: 238 KNRTKEEKQKIKE 250

[202][TOP]
>UniRef100_C4Q6C7 DNA topoisomerase type I, putative n=1 Tax=Schistosoma mansoni
           RepID=C4Q6C7_SCHMA
          Length = 652

 Score = 84.7 bits (208), Expect = 4e-15
 Identities = 51/133 (38%), Positives = 68/133 (51%), Gaps = 2/133 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           +RWWE   K DG VKW  LEH G  F P YE  P      Y+   + L   AEEVA FYA
Sbjct: 124 WRWWEEQKKDDG-VKWKFLEHKGPLFAPPYERLPSSVHFHYDSKPIKLSDHAEEVAGFYA 182

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  D+  KE F  NFF D+   + + +  + I SL KCDF  +  +      K   E+
Sbjct: 183 RMLDHDYTTKEVFNYNFFRDWVKTMNEEE-RRTIKSLSKCDFREMHQYF----LKLSEER 237

Query: 480 KAQTTAERKEARE 518
           K +T  E+++ +E
Sbjct: 238 KNRTKEEKQKIKE 250

[203][TOP]
>UniRef100_C9SIQ6 DNA topoisomerase n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9SIQ6_9PEZI
          Length = 891

 Score = 84.3 bits (207), Expect = 5e-15
 Identities = 61/184 (33%), Positives = 89/184 (48%), Gaps = 6/184 (3%)
 Frame = +3

Query: 12  AERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTLEHN 191
           A+    G KAK        GR+A     + E E  +    WW    K D  VKWTTLEHN
Sbjct: 207 AKTPAKGTKAKAATPA-KKGRSAKKE-ESEEAEEDEAVDEWWNEPKKEDDSVKWTTLEHN 264

Query: 192 GVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQT-DHVLKEKFRSNFFADF 362
           GV    +YE  P    L+Y+G  L+LP   EE A F+ S   + ++V    F+ NFF DF
Sbjct: 265 GVLMDYKYEPLPKNVKLVYDGKPLNLPLQVEEAAWFFGSMFHSKNNVDNPTFQKNFFEDF 324

Query: 363 RALLADTKFA--KVITSLEKCDFSRIE-AHLEDEKAKKKAEKKAQTTAERKEAREAEAER 533
           R ++ +   A  K    ++  DF +I    + D   ++ A +K +T  E+K+ +E +  R
Sbjct: 325 REVIKEHGSATDKDGKKVDIKDFHKINWQPMADYAEQQSAMRKNRTKEEKKQIKEEKDAR 384

Query: 534 VRQF 545
              F
Sbjct: 385 EEPF 388

[204][TOP]
>UniRef100_B4MU44 GK23720 n=1 Tax=Drosophila willistoni RepID=B4MU44_DROWI
          Length = 638

 Score = 83.2 bits (204), Expect = 1e-14
 Identities = 48/130 (36%), Positives = 63/130 (48%), Gaps = 2/130 (1%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE  N+ DG  KW TLEH G  F   Y+  P     +Y+G    L    EE ATFYA
Sbjct: 66  WKWWEEENRNDGN-KWLTLEHKGPVFTEPYKRLPANVRFLYDGKPFQLSKETEEAATFYA 124

Query: 300 SKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEK 479
             L  +      F  NFF DFR L    +  K+I    KC+F  I    + E  K+ A  
Sbjct: 125 KMLNHECCRNRIFYRNFFRDFR-LTMTARERKIIKDFHKCNFYEIFKFFQAESNKRLAAT 183

Query: 480 KAQTTAERKE 509
           K +  A+RK+
Sbjct: 184 KEEKLAKRKK 193

[205][TOP]
>UniRef100_A5KB33 Topoisomerase I, putative n=1 Tax=Plasmodium vivax
           RepID=A5KB33_PLAVI
          Length = 931

 Score = 82.8 bits (203), Expect = 2e-14
 Identities = 51/154 (33%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 284
           EN +   RWWE   ++TD  V+W  LEH G+ F P Y  H  P+ Y+ ++L L   AEE+
Sbjct: 170 ENFEPINRWWEKIDHQTD--VQWHYLEHRGLIFSPPYVQHNIPIFYKSIKLQLNEKAEEL 227

Query: 285 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 446
           AT++ S + +D+  KEKF  NFF  F   L      +    + L+K D S  +      +
Sbjct: 228 ATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENESKLKKGDISNFKFIDFMPI 287

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 548
           +D   K + EK  +T  E++E ++  +E+   +T
Sbjct: 288 KDHLVKLREEKLNRTKEEKEEEKKLRSEKELPYT 321

[206][TOP]
>UniRef100_UPI0000E471B7 PREDICTED: similar to topoisomerase I beta n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E471B7
          Length = 879

 Score = 82.4 bits (202), Expect = 2e-14
 Identities = 49/164 (29%), Positives = 84/164 (51%), Gaps = 2/164 (1%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           K K++++    K   +D+  +    A +  GA E  + +G              VKW  L
Sbjct: 339 KTKSKKKSKDTKKDKKDKKDTSRSKAKTGRGAKETPHPEG--------------VKWMFL 384

Query: 183 EHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFA 356
           EH G  F P YEP  +     Y+G E+ L   AEEVA FYA  ++ D+  K+ F +NF+ 
Sbjct: 385 EHTGPLFAPPYEPLPNSVKFFYDGEEMKLSEEAEEVAGFYARMIEHDYTTKDVFNNNFYR 444

Query: 357 DFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQ 488
           D++ ++   + A +I  ++KC+F +I A+ + +  ++KA  K +
Sbjct: 445 DWKKVMTHEEKA-IIKDMKKCNFKQIHAYYQRKSEERKAMSKEE 487

[207][TOP]
>UniRef100_B4LSA9 GJ16237 n=1 Tax=Drosophila virilis RepID=B4LSA9_DROVI
          Length = 557

 Score = 82.4 bits (202), Expect = 2e-14
 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
 Frame = +3

Query: 162 EVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335
           +VKW TLEHNG  FP  YE  P     +Y+   + L   AEEVATFYA  L T  V   +
Sbjct: 65  KVKWQTLEHNGPLFPGAYERLPENVHFLYDNCPIELTEQAEEVATFYAKVLGTPFVELSE 124

Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAR 515
           F  NFF DFR+ L+  +     TS + C+F +I  +LE+++  +  ++  +         
Sbjct: 125 FNENFFKDFRSCLS-VEQRLHFTSFDLCNFQKIHQYLEEQQEARSQQELEEDERYGYCYI 183

Query: 516 EAEAERVRQF 545
           + E  R+ QF
Sbjct: 184 DGERHRINQF 193

[208][TOP]
>UniRef100_Q7RE42 Eukaryotic DNA topoisomerase I, DNA binding, putative n=1
           Tax=Plasmodium yoelii yoelii RepID=Q7RE42_PLAYO
          Length = 886

 Score = 82.0 bits (201), Expect = 3e-14
 Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTTL 182
           +VK E+++A    K +  T+   +     +     EN +   RWWE  +    + +W  L
Sbjct: 160 RVKEEKKIAN---KVKKETVKKPKK----IPKKSEENFEPINRWWEKIDD-QSDTQWNYL 211

Query: 183 EHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADF 362
           EH G+ F P Y  H  P+ Y+ +++ L P AEE+AT++ S + TD+  K+KF  NFF  F
Sbjct: 212 EHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELATYWCSVIGTDYCTKDKFILNFFKTF 271

Query: 363 RALLADTKFAK----------VITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEA 512
              L      +           I++ +  DF  I+ HL     K + E+  +T  E++E 
Sbjct: 272 INNLEKDNIIRRENENKIKNGDISNFKFIDFMTIKEHL----IKLREERLNKTKEEKEEE 327

Query: 513 REAEAERVRQFT 548
           ++   E+   +T
Sbjct: 328 KKIRMEKELPYT 339

[209][TOP]
>UniRef100_Q8I3Z9 Topoisomerase I n=2 Tax=Plasmodium falciparum RepID=Q8I3Z9_PLAF7
          Length = 839

 Score = 81.6 bits (200), Expect = 3e-14
 Identities = 50/154 (32%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 284
           EN +   RWWE   ++TD  ++W  LEH G+ F P Y  H  P+ Y+ +++ L   +EE+
Sbjct: 136 ENFEPINRWWEKIDDQTD--IQWNYLEHRGLIFSPPYVQHHVPIFYKSIKIELNAKSEEL 193

Query: 285 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 446
           AT++ S + +D+  KEKF  NFF  F   L +    K    T L+K D S  +      +
Sbjct: 194 ATYWCSAIGSDYCTKEKFILNFFKTFINSLENDNIIKQENETKLKKGDISNFKFIDFMPI 253

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 548
           +D   K + EK  +T  E++E ++   E+   +T
Sbjct: 254 KDHLLKLREEKLNKTKEEKEEEKKMRMEKELPYT 287

[210][TOP]
>UniRef100_Q4XMK5 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium chabaudi
           RepID=Q4XMK5_PLACH
          Length = 429

 Score = 80.5 bits (197), Expect = 7e-14
 Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 13/147 (8%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 287
           EN +   RWWE  +    + +W  LEH G+ F P Y  H  P+ Y+ +++ L P AEE+A
Sbjct: 163 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSIKIELNPKAEELA 221

Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 437
           T++ S + TD+  K+KF  NFF  F   L      +           I++ +  DF  I+
Sbjct: 222 TYWCSVIGTDYCTKDKFILNFFKTFINNLEKDNIIRRENEHKVKNGDISNFKFIDFMTIK 281

Query: 438 AH---LEDEKAKKKAEKKAQTTAERKE 509
            H   L DE+  K  E+K +    R E
Sbjct: 282 EHLIKLRDERLNKTKEEKEEDKKIRME 308

[211][TOP]
>UniRef100_B3L6G4 Topoisomerase I, putative n=1 Tax=Plasmodium knowlesi strain H
           RepID=B3L6G4_PLAKH
          Length = 924

 Score = 80.5 bits (197), Expect = 7e-14
 Identities = 49/149 (32%), Positives = 78/149 (52%), Gaps = 7/149 (4%)
 Frame = +3

Query: 108 ENGDGGFRWWEA-GNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEV 284
           EN +   RWWE   ++TD  ++W  LEH G+ F P Y  H  P+ Y+ ++L L   AEE+
Sbjct: 170 ENFEPINRWWEKIDHQTD--IQWHYLEHRGLIFSPPYVQHHIPIFYKSIKLELNEKAEEL 227

Query: 285 ATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKV--ITSLEKCDFSRIE----AHL 446
           AT++ S + +D+  KEKF  NFF  F   L      +      L+K D S  +      +
Sbjct: 228 ATYWCSVIGSDYCTKEKFILNFFRTFICTLEKDNIIRQENENKLKKGDISNFQFIDFMPI 287

Query: 447 EDEKAKKKAEKKAQTTAERKEAREAEAER 533
           +D   K + EK  +T  E++E ++  +E+
Sbjct: 288 KDHLVKLREEKLNRTKEEKEEEKKLRSEK 316

[212][TOP]
>UniRef100_A0CF77 Chromosome undetermined scaffold_174, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0CF77_PARTE
          Length = 725

 Score = 80.1 bits (196), Expect = 1e-13
 Identities = 51/144 (35%), Positives = 72/144 (50%), Gaps = 14/144 (9%)
 Frame = +3

Query: 120 GGFR-----WWEAGNKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLP 266
           GGF+     WWE  N  + E +      W  LEH+GV FPP Y+ H   LIY G  + L 
Sbjct: 17  GGFQARSHNWWEEANPEESEEEEQQGQEWRYLEHHGVLFPPFYKRHNVGLIYNGKLITLT 76

Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446
              EE+ T++A  + + +  KE +R NF +     L  TKF      L+K DF++I  HL
Sbjct: 77  EEQEELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIREHL 129

Query: 447 EDE---KAKKKAEKKAQTTAERKE 509
           E +   +  K  E+K Q   ER +
Sbjct: 130 EQQRLLRLNKSDEQKKQEKLERDQ 153

[213][TOP]
>UniRef100_Q9XGL1 DNA topoisomerase I n=1 Tax=Daucus carota RepID=Q9XGL1_DAUCA
          Length = 909

 Score = 79.7 bits (195), Expect = 1e-13
 Identities = 45/119 (37%), Positives = 66/119 (55%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
           KWTTL HNGV FPP Y+PHG  ++Y+   + L    EEV      ++ T+++ K  FR N
Sbjct: 350 KWTTLVHNGVIFPPPYKPHGVKMLYKESPVDLTLNQEEVHMIAVMQILTEYLTKPVFREN 409

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAE 524
              D++ +L       +I +L+ CDF+ I      E  + K EKK Q +AE K+A + E
Sbjct: 410 VMNDWKIILGRN---HIIKNLDDCDFTPIY-----EWFRLKKEKKKQMSAEEKKAVKEE 460

[214][TOP]
>UniRef100_Q4YYG2 Topoisomerase I, putative (Fragment) n=1 Tax=Plasmodium berghei
           RepID=Q4YYG2_PLABE
          Length = 805

 Score = 79.7 bits (195), Expect = 1e-13
 Identities = 48/157 (30%), Positives = 78/157 (49%), Gaps = 10/157 (6%)
 Frame = +3

Query: 108 ENGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVA 287
           EN +   RWWE  +    + +W  LEH G+ F P Y  H  P+ Y+ +++ L P AEE+A
Sbjct: 133 ENFEPINRWWEKIDD-QSDTQWNYLEHRGIIFSPPYVQHNIPIFYKSVKIELNPKAEELA 191

Query: 288 TFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAK----------VITSLEKCDFSRIE 437
           T++ S + TD+  KEKF  NFF  F   L      +           I++ +  DF  I+
Sbjct: 192 TYWCSVIGTDYCTKEKFILNFFKTFINNLEKDNIIRRENEHKLKNGDISNFKFIDFMTIK 251

Query: 438 AHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQFT 548
            +L     K + E+  +T  E++E ++   E+   +T
Sbjct: 252 ENL----IKLREERLNKTKEEKEEEKKIRMEKELPYT 284

[215][TOP]
>UniRef100_B3S6N7 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax
           adhaerens RepID=B3S6N7_TRIAD
          Length = 560

 Score = 79.7 bits (195), Expect = 1e-13
 Identities = 53/140 (37%), Positives = 66/140 (47%), Gaps = 4/140 (2%)
 Frame = +3

Query: 135 WEAGNKTDGEVKWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKL 308
           WE   K D  VKW TLEH G    P YE  P      Y+G    L    EE A FYA  L
Sbjct: 1   WEEDTK-DNSVKWKTLEHKGPLLAPPYERLPSNVQFYYDGQTFPLSDKTEEAAGFYAKML 59

Query: 309 QTDHVLKEKFRSNFFADFRALL--ADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKK 482
             D+  K+ F  NF+ DFR  +  A+    KV +   KCDFS+I      E  K KAE++
Sbjct: 60  DHDYTQKKIFNDNFWTDFRKEMTPAEKNHIKVFS---KCDFSKIA-----EYYKMKAEER 111

Query: 483 AQTTAERKEAREAEAERVRQ 542
              + E K   + E E + Q
Sbjct: 112 RNMSKEEKNKLKKENEELMQ 131

[216][TOP]
>UniRef100_O17966-2 Isoform b of DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans
           RepID=O17966-2
          Length = 734

 Score = 79.0 bits (193), Expect = 2e-13
 Identities = 55/180 (30%), Positives = 90/180 (50%), Gaps = 5/180 (2%)
 Frame = +3

Query: 6   VKAERRVAGGKAKTEDRTLSP---GRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWT 176
           VK ++R + G  K++  T      G+         + E+ +  + WW+   K  G VKW 
Sbjct: 130 VKPQKRKSKGAEKSKPSTSKKDAGGKKEPPKKKVKKEEDIEDIWEWWKEEKKPAG-VKWN 188

Query: 177 TLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNF 350
           +L+H G  F P Y P        Y G ++ L    EE+A FYA  L  ++  KE F  NF
Sbjct: 189 SLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYAGVLDHEYSTKEAFNKNF 248

Query: 351 FADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAE 530
             D+R ++   +  + I  L+KCDF  I+A+ ++++  +KA  K +   + KE +EAE +
Sbjct: 249 MKDWRKVMT-VEERERIHDLKKCDFRAIDAYQKEQREIRKAMTK-EEKLKIKEEKEAEVK 306

[217][TOP]
>UniRef100_O17966 DNA topoisomerase 1 n=1 Tax=Caenorhabditis elegans RepID=TOP1_CAEEL
          Length = 806

 Score = 79.0 bits (193), Expect = 2e-13
 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 5/181 (2%)
 Frame = +3

Query: 3   KVKAERRVAGGKAKTEDRTLSP---GRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKW 173
           K K ++R + G  K++  T      G+         + E+ +  + WW+   K  G VKW
Sbjct: 201 KAKKKKRKSKGAEKSKPSTSKKDAGGKKEPPKKKVKKEEDIEDIWEWWKEEKKPAG-VKW 259

Query: 174 TTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSN 347
            +L+H G  F P Y P        Y G ++ L    EE+A FYA  L  ++  KE F  N
Sbjct: 260 NSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLTLETEEIAQFYAGVLDHEYSTKEAFNKN 319

Query: 348 FFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEA 527
           F  D+R ++   +  + I  L+KCDF  I+A+ ++++  +KA  K +   + KE +EAE 
Sbjct: 320 FMKDWRKVMT-VEERERIHDLKKCDFRAIDAYQKEQREIRKAMTK-EEKLKIKEEKEAEV 377

Query: 528 E 530
           +
Sbjct: 378 K 378

[218][TOP]
>UniRef100_UPI000187DC43 hypothetical protein MPER_08287 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DC43
          Length = 343

 Score = 78.6 bits (192), Expect = 3e-13
 Identities = 43/104 (41%), Positives = 60/104 (57%), Gaps = 2/104 (1%)
 Frame = +3

Query: 240 YEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVI--TSLE 413
           ++G  L+LPP +EEVA FYA+ ++TDH     F  NFF D+  +L D      I  T  +
Sbjct: 6   HDGKVLNLPPESEEVAGFYAALIETDHAQDAAFNKNFFEDWLKVLQDHPPCNGIKATDFD 65

Query: 414 KCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREAEAERVRQF 545
           KCDF  +  + E EKAKKKA   A+    +K+  EAEA+   +F
Sbjct: 66  KCDFRPMYEYFEAEKAKKKATSAAEKKEIKKQKDEAEAKYTHRF 109

[219][TOP]
>UniRef100_A0DKX8 Chromosome undetermined scaffold_55, whole genome shotgun sequence
           n=1 Tax=Paramecium tetraurelia RepID=A0DKX8_PARTE
          Length = 596

 Score = 78.2 bits (191), Expect = 4e-13
 Identities = 50/144 (34%), Positives = 73/144 (50%), Gaps = 14/144 (9%)
 Frame = +3

Query: 120 GGFR-----WWEAGNKTDGEVK------WTTLEHNGVYFPPEYEPHGFPLIYEGMELHLP 266
           GGF+     WWE  N  + E +      W  LEH+GV FPP Y+ H   LIY G  + L 
Sbjct: 17  GGFQARSHNWWEEANPEESEEEEQQGQEWRYLEHHGVLFPPFYKRHNVGLIYNGKLITLT 76

Query: 267 PAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHL 446
              EE+ T++A  + + +  KE +R NF +     L  TKF      L+K DF++I+ +L
Sbjct: 77  EEQEELCTYWAQSIGSPYENKEIYRKNFES-----LMQTKFEGF--QLDKADFTKIKEYL 129

Query: 447 EDE---KAKKKAEKKAQTTAERKE 509
           E +   +  K  E+K Q   ER +
Sbjct: 130 EQQRLLRLNKSDEQKKQEKLERDQ 153

[220][TOP]
>UniRef100_B4KJC7 GI24443 n=1 Tax=Drosophila mojavensis RepID=B4KJC7_DROMO
          Length = 555

 Score = 76.3 bits (186), Expect = 1e-12
 Identities = 44/128 (34%), Positives = 66/128 (51%), Gaps = 2/128 (1%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFR 341
           KW TL HNG  FP ++E  P      Y+   + L   AEEVATFYA  ++T  V   +F 
Sbjct: 64  KWQTLRHNGPCFPADHERLPADVKFYYDNCPVELTEQAEEVATFYAKLMKTAFVQMREFN 123

Query: 342 SNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKEAREA 521
            NFF +FR+ L++ +  + IT  E C+F  I  +LE ++  +K     +         + 
Sbjct: 124 QNFFNEFRSCLSEEQ-RRYITCFELCNFCDISQYLECQREDEKERIAEENKLYGYCLVDG 182

Query: 522 EAERVRQF 545
           E+ R+ QF
Sbjct: 183 ESRRITQF 190

[221][TOP]
>UniRef100_Q3ULF5 Putative uncharacterized protein (Fragment) n=1 Tax=Mus musculus
           RepID=Q3ULF5_MOUSE
          Length = 291

 Score = 75.1 bits (183), Expect = 3e-12
 Identities = 37/82 (45%), Positives = 47/82 (57%), Gaps = 2/82 (2%)
 Frame = +3

Query: 126 FRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYA 299
           ++WWE     +G +KW  LEH G  F P YEP        Y+G  + L P AEEVATF+A
Sbjct: 205 WKWWEEERYPEG-IKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFA 263

Query: 300 SKLQTDHVLKEKFRSNFFADFR 365
             L  ++  KE FR NFF D+R
Sbjct: 264 KMLDHEYTTKEIFRKNFFKDWR 285

[222][TOP]
>UniRef100_A8PY85 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS
           7966 RepID=A8PY85_MALGO
          Length = 877

 Score = 73.2 bits (178), Expect = 1e-11
 Identities = 46/120 (38%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
 Frame = +3

Query: 159 GEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332
           GE +WTTL H G  FP  Y P      L Y+G  + LPP +EEVA FYA KL++ H    
Sbjct: 118 GEQRWTTLIHKGPKFPEPYTPLPKDVMLKYDGHPVPLPPESEEVAMFYAVKLESQHASNP 177

Query: 333 KFRSNFFADFRALLAD--TKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
            F  NFF DF   L     K    I   EK DF  +  +    K  +   KK+   + RK
Sbjct: 178 IFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSMRK 237

[223][TOP]
>UniRef100_A9A2H9 2-alkenal reductase n=1 Tax=Nitrosopumilus maritimus SCM1
           RepID=A9A2H9_NITMS
          Length = 551

 Score = 73.2 bits (178), Expect = 1e-11
 Identities = 49/122 (40%), Positives = 66/122 (54%), Gaps = 4/122 (3%)
 Frame = +3

Query: 165 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344
           +KW TL+H G+ FPP YE  G  +  +G ++ L    EE+   +A K  T +   + F+ 
Sbjct: 1   MKWKTLQHKGILFPPAYEAQGIKIKIKGEKVDLNLDQEEMIYQWAKKKDTPYAQDKVFQK 60

Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK----KAEKKAQTTAERKEA 512
           NF ADF   L D+KF K+  S E  DFS     ++ EK  K    K EKKA   A+RKE 
Sbjct: 61  NFTADFAKTL-DSKFKKI--SYEDIDFSDAYKLVDKEKDLKEMMTKEEKKA-IAAKRKEL 116

Query: 513 RE 518
           RE
Sbjct: 117 RE 118

[224][TOP]
>UniRef100_A0RU10 DNA topoisomerase IB n=1 Tax=Cenarchaeum symbiosum
           RepID=A0RU10_CENSY
          Length = 519

 Score = 72.4 bits (176), Expect = 2e-11
 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 3/121 (2%)
 Frame = +3

Query: 165 VKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFRS 344
           + W TL+H+G++FPPE+E  GF +  +G +++L P  EE+A  +A K  T +   + F+ 
Sbjct: 1   MNWKTLQHSGIHFPPEHEVKGFKIKVKGKQVNLTPLQEEMAYQWAKKKDTPYAQDKVFQK 60

Query: 345 NFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKK---KAEKKAQTTAERKEAR 515
           NF  DF   L      K +      DFS     ++ EK KK     E+K +  A+RKE R
Sbjct: 61  NFARDFAKELGIKLLYKDL------DFSEAYRLVDMEKDKKDMMTKEEKKEIAAKRKEIR 114

Query: 516 E 518
           E
Sbjct: 115 E 115

[225][TOP]
>UniRef100_P41511 DNA topoisomerase 1 n=1 Tax=Ustilago maydis RepID=TOP1_USTMA
          Length = 1019

 Score = 71.6 bits (174), Expect = 3e-11
 Identities = 47/132 (35%), Positives = 63/132 (47%), Gaps = 5/132 (3%)
 Frame = +3

Query: 159 GEVKWTTLEHNGVYFPPEYEP--HGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKE 332
           GE KW  L H G  FP  Y+P      L Y+G  + LP   EE+A FYA KL+T H    
Sbjct: 159 GEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNA 218

Query: 333 KFRSNFFADFRALLA--DTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKA-QTTAER 503
            F  NFF DF+  L     +    I S +K DF  +  +    K  +   KKA   +A +
Sbjct: 219 IFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARK 278

Query: 504 KEAREAEAERVR 539
           +E  E +AE  +
Sbjct: 279 REIEERKAEETK 290

[226][TOP]
>UniRef100_B3MVN1 GF23753 n=1 Tax=Drosophila ananassae RepID=B3MVN1_DROAN
          Length = 240

 Score = 70.9 bits (172), Expect = 6e-11
 Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 2/103 (1%)
 Frame = +3

Query: 168 KWTTLEHNGVYFPPEYE--PHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEKFR 341
           KWTTL HNG  F   Y+  P      YE + L L P AEE+AT YA  + +   + + F 
Sbjct: 18  KWTTLSHNGPLFVDHYQALPKEVAFYYEDLPLKLNPTAEELATLYAKFMNSPLAITDTFN 77

Query: 342 SNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKK 470
            NFF DF++ L+     + I S E CDF++I  +++ ++  ++
Sbjct: 78  ENFFKDFQSHLS-RALRRQILSFELCDFTKIAFYIQGQQGVQR 119

[227][TOP]
>UniRef100_Q24BB2 Eukaryotic DNA topoisomerase I, catalytic core family protein n=1
           Tax=Tetrahymena thermophila SB210 RepID=Q24BB2_TETTH
          Length = 713

 Score = 70.1 bits (170), Expect = 1e-10
 Identities = 38/118 (32%), Positives = 61/118 (51%)
 Frame = +3

Query: 156 DGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEEVATFYASKLQTDHVLKEK 335
           + ++KW  LEH+GV FP  ++ H     Y+G  + L    EE+AT+++  L TD   K K
Sbjct: 131 NSDIKWKYLEHHGVLFPDYWQKHNVRPRYDGKPIDLNLLQEEMATYWSQTLGTDWEHKPK 190

Query: 336 FRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERKE 509
           +R NF   F       K        +K DF+ I+ HLE++K  +K   K +   E+++
Sbjct: 191 YRENFSKQFLDTFGKDKGK---YDFDKFDFTPIKIHLEEQKEIRKNRSKEEKNQEKQK 245

[228][TOP]
>UniRef100_UPI0001A2BD10 UPI0001A2BD10 related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2BD10
          Length = 349

 Score = 65.9 bits (159), Expect = 2e-09
 Identities = 58/192 (30%), Positives = 84/192 (43%), Gaps = 12/192 (6%)
 Frame = +3

Query: 3   KVKAERRVAGGKAK-TEDRTLSPGRAAGSPLGAAEGENGDGGFRWWEAGNKTDGEVKWTT 179
           KVK +++    K K  +D+    G+         + E  D  ++WWE G   D  VKW++
Sbjct: 79  KVKKDKKDEKKKEKGKKDKNDEEGKKEKGKKEDKKEEESDK-WKWWEEGKSCDA-VKWSS 136

Query: 180 LEHNGVYFPPEYE--PHGFPLIYEG---------MELHLPPAAEEVATFYASKLQTDHVL 326
           LEH G YF P+YE  P      Y+G         + LH  P      T Y   L      
Sbjct: 137 LEHKGPYFAPDYEPLPANICFYYDGNNSERTAATLLLHSDPDLISDYTVYVCVL------ 190

Query: 327 KEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRIEAHLEDEKAKKKAEKKAQTTAERK 506
              FR  F  D + +  + +  K+IT+L KCDF+ I  +      +K  EKK  T    K
Sbjct: 191 ---FRMFFACDCQEMTKEER--KLITTLSKCDFTHIHKYF----VEKAEEKKTMT----K 237

Query: 507 EAREAEAERVRQ 542
           E  + EA R+ +
Sbjct: 238 EVLKDEAARLME 249

[229][TOP]
>UniRef100_UPI000194EAF8 PREDICTED: similar to rCG63558, partial n=1 Tax=Taeniopygia guttata
           RepID=UPI000194EAF8
          Length = 79

 Score = 56.6 bits (135), Expect = 1e-06
 Identities = 32/85 (37%), Positives = 47/85 (55%)
 Frame = +3

Query: 255 LHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI 434
           + L   AEEVATF+A  L  ++  KE FR NFF D+R  +   +    ITSL KCDF+ +
Sbjct: 1   MKLSTKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTSEE-KSTITSLSKCDFTHM 59

Query: 435 EAHLEDEKAKKKAEKKAQTTAERKE 509
             +      K ++E + Q + E K+
Sbjct: 60  SQYF-----KAQSEARKQMSKEEKQ 79

[230][TOP]
>UniRef100_Q8RX06 Putative DNA topoisomerase I (Fragment) n=1 Tax=Arabidopsis
           thaliana RepID=Q8RX06_ARATH
          Length = 514

 Score = 56.6 bits (135), Expect = 1e-06
 Identities = 35/91 (38%), Positives = 53/91 (58%), Gaps = 1/91 (1%)
 Frame = +3

Query: 276 EEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCDFSRI-EAHLED 452
           EEVAT +A   +TD+  K +FR NF+ D+R LL       VI  L+ CDF+ I E HLE+
Sbjct: 4   EEVATMFAVMRETDYYTKPQFRENFWNDWRRLLGK---KHVIQKLDDCDFTPIYEWHLEE 60

Query: 453 EKAKKKAEKKAQTTAERKEAREAEAERVRQF 545
                K +KK  +T E+K  +E + ++  ++
Sbjct: 61  -----KEKKKQMSTEEKKALKEEKMKQEEKY 86

[231][TOP]
>UniRef100_C5KK36 Putative uncharacterized protein n=1 Tax=Perkinsus marinus ATCC
           50983 RepID=C5KK36_9ALVE
          Length = 479

 Score = 56.2 bits (134), Expect = 2e-06
 Identities = 60/154 (38%), Positives = 70/154 (45%), Gaps = 2/154 (1%)
 Frame = +1

Query: 94  GPPKGRMETAAFGGGKRETRRMGRSSGPLSNT-TASTFRPSMSRTGFRLSTKAWSCICLR 270
           G  +GR  T      +R TRR  RSS   S   T S+ R S  R G R + +A S    R
Sbjct: 294 GGRRGRRRTRRAKSSRRRTRRRTRSSARSSRRRTRSSARSSGGRRGRRRTRRAKSSR-RR 352

Query: 271 RRKRLPPFMRPSYRRTMC*RRSSDPTSSRTSEPSWR-TPSLPR*SPAWKSVTLVGSRRT* 447
            R+R     R S RRT    RSS   S R +  S R T S  R + + +  T    RRT 
Sbjct: 353 TRRRTRSSARSSRRRTRSSARSSARNSRRRTRSSRRRTRSNRRRTRSSRRRTRSSRRRT- 411

Query: 448 RMKRRRRRRRRRRRRRPSARRPVRLRPSVFVSSR 549
           R  RRR R  RRR  R S RR  R   S   SSR
Sbjct: 412 RSSRRRTRSSRRRSARSSRRRTRRRTRSSARSSR 445

[232][TOP]
>UniRef100_B8CC90 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B8CC90_THAPS
          Length = 178

 Score = 55.5 bits (132), Expect = 3e-06
 Identities = 24/57 (42%), Positives = 33/57 (57%)
 Frame = +3

Query: 111 NGDGGFRWWEAGNKTDGEVKWTTLEHNGVYFPPEYEPHGFPLIYEGMELHLPPAAEE 281
           +G   ++WW  GN      +W  +EH GV FP  Y PHG  ++Y+G E+ L PA EE
Sbjct: 122 HGMQAYQWWN-GNDPPKGCQWVKMEHAGVSFPEGYVPHGVKMLYDGTEVELGPAEEE 177

[233][TOP]
>UniRef100_UPI000176075D PREDICTED: similar to DNA topoisomerase I n=1 Tax=Danio rerio
           RepID=UPI000176075D
          Length = 531

 Score = 54.3 bits (129), Expect = 6e-06
 Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 1/93 (1%)
 Frame = +3

Query: 243 EGMELHLPPAAEEVATFYASKLQTDHVLKEKFRSNFFADFRALLADTKFAKVITSLEKCD 422
           E ++L LP  AEEVA ++A  L  ++  KE FR+NFF D+R  +   +  ++I  L+KCD
Sbjct: 11  EPVKLSLP--AEEVALYFAQMLDHEYTTKEVFRNNFFKDWRKEMT-LEERQLIMDLKKCD 67

Query: 423 FSRIEA-HLEDEKAKKKAEKKAQTTAERKEARE 518
           F  + A H E  +A+K   K+ +     KEA +
Sbjct: 68  FGELHAMHKEKVEARKNLSKEEKLV--NKEANQ 98